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https://www.readbyqxmd.com/read/29040921/effect-of-local-cooling-on-excitation-contraction-coupling-in-myasthenic-muscle-another-mechanism-of-ice-pack-test-in-myasthenia-gravis
#1
Daisuke Yamamoto, Tomihiro Imai, Emiko Tsuda, Takayoshi Hozuki, Rika Yamauchi, Shin Hisahara, Jun Kawamata, Shun Shimohama
OBJECTIVE: The ice-pack test is a convenient diagnostic testing procedure for myasthenia gravis (MG). We investigated the underlying mechanism of the ice-pack test performed on bilateral masseters. METHODS: We performed trigeminal repetitive nerve stimulation (RNS), excitation-contraction (E-C) coupling assessment (Imai's method) and bite force measurement before and after cooling of the masseters in MG patients and normal controls. After placing the ice-pack on the masseters for 3min, serial recordings of the three tests were performed at various time intervals during 10min after cooling...
September 22, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29040653/regulatory-mechanisms-of-sperm-flagellar-motility-by-metachronal-and-synchronous-sliding-of-doublet-microtubules
#2
Gen L Takei, Masakatsu Fujinoki, Kaoru Yoshida, Sumio Ishijima
STUDY QUESTION: What is the role of metachronal and synchronous sliding in sperm flagellar motility? SUMMARY ANSWER: Both metachronal and oscillatory synchronous sliding are essential for sperm flagellar motility, while the change in mode of synchronous sliding between the non-oscillatory synchronous sliding of a specific pair of the doublet microtubules and the oscillatory synchronous sliding between most pairs of doublet microtubules modulates the sperm flagellar motility...
October 11, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29040591/revised-distribution-of-bactrocera-tryoni-in-eastern-australia-and-effect-on-possible-incursions-of-mediterranean-fruit-fly-development-of-australia-s-eastern-trading-block
#3
Bernard C Dominiak, Richard Mapson
Bactrocera tryoni (Froggatt) (Diptera: Tephritidae), commonly called 'Queensland fruit fly' in Australia, and Mediterranean fruit fly (Ceratitis capitata Wiedemann) (Diptera: Tephritidae) are the two most economically important fruit fly in Australia with B. tryoni in the east and Mediterranean fruit fly in the west. The two species coexisted for several decades, but it is believed that B. tryoni displaced Mediterranean fruit fly. In southeastern Australia, this was deemed inadequate for export market access, and a large fruit fly free zone (fruit fly exclusion zone) was developed in 1996 where B...
October 11, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29040289/sole-vibration-improves-locomotion-through-the-recovery-of-joint-movements-in-a-mouse-cast-model
#4
Atsushi Doi, Kazuaki Miyamoto, Yu-Shin Nakano, Juntaro Sakasaki, Syota Kasae, Keisuke Nishimura, Min-Chul Shin, Megumu Yoshimura
We investigated the effects of a vibratory stimulus on the plantar surface of the hind limb for motor, sensory, and locomotive function using a mouse cast model. The right knee joint of C57BL/6 male mice (7 weeks, 20 g, n = 31) was flexed with aluminum splint and tape for 6 weeks. These mice were randomly divided into 2 groups (control group, n = 11 and vibration group, n = 12). The mice in the vibration group received vibration on the sole of the ankle for 15 minutes per day, 5 days per week. After the knee joint cast was removed, we measured the range of motion (ROM) of both knee and ankle joints and the sensory threshold of the sole...
2017: PloS One
https://www.readbyqxmd.com/read/29040279/social-exclusion-leads-to-attentional-bias-to-emotional-social-information-evidence-from-eye-movement
#5
Zhuohao Chen, Jinchen Du, Min Xiang, Yan Zhang, Shuyue Zhang
Social exclusion has many effects on individuals, including the increased need to belong and elevated sensitivity to social information. Using a self-reporting method, and an eye-tracking technique, this study explored people's need to belong and attentional bias towards the socio-emotional information (pictures of positive and negative facial expressions compared to those of emotionally-neutral expressions) after experiencing a brief episode of social exclusion. We found that: (1) socially-excluded individuals reported higher negative emotions, lower positive emotions, and stronger need to belong than those who were not socially excluded; (2) compared to a control condition, social exclusion caused a longer response time to probe dots after viewing positive or negative face images; (3) social exclusion resulted in a higher frequency ratio of first attentional fixation on both positive and negative emotional facial pictures (but not on the neutral pictures) than the control condition; (4) in the social exclusion condition, participants showed shorter first fixation latency and longer first fixation duration to positive pictures than neutral ones but this effect was not observed for negative pictures; (5) participants who experienced social exclusion also showed longer gazing duration on the positive pictures than those who did not; although group differences also existed for the negative pictures, the gaze duration bias from both groups showed no difference from chance...
2017: PloS One
https://www.readbyqxmd.com/read/29036855/diagnostic-criteria-for-persistent-postural-perceptual-dizziness-pppd-consensus-document-of-the-committee-for-the-classification-of-vestibular-disorders-of-the-b%C3%A3-r%C3%A3-ny-society
#6
Jeffrey P Staab, Annegret Eckhardt-Henn, Arata Horii, Rolf Jacob, Michael Strupp, Thomas Brandt, Adolfo Bronstein
This paper presents diagnostic criteria for persistent postural-perceptual dizziness (PPPD) to be included in the International Classification of Vestibular Disorders (ICVD). The term PPPD is new, but the disorder is not. Its diagnostic criteria were derived by expert consensus from an exhaustive review of 30 years of research on phobic postural vertigo, space-motion discomfort, visual vertigo, and chronic subjective dizziness. PPPD manifests with one or more symptoms of dizziness, unsteadiness, or non-spinning vertigo that are present on most days for three months or more and are exacerbated by upright posture, active or passive movement, and exposure to moving or complex visual stimuli...
October 7, 2017: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29036578/the-roles-of-membranes-and-associated-cytoskeleton-in-plant-virus-replication-and-cell-to-cell-movement
#7
Nicolas Pitzalis, Manfred Heinlein, Gian Pietro Di Sansebastiano
The infection of plants by viruses depends on cellular mechanisms that support the replication of the viral genomes, and the cell-to-cell and systemic movement of the virus via plasmodesmata (PD) and the connected phloem. While the propagation of some viruses requires the conventional endoplasmic reticulum (ER)-Golgi pathway, others replicate and spread between cells in association with the ER and are independent of this pathway. Using selected viruses as examples, this review re-examines the involvement of membranes and the cytoskeleton during virus infection and proposes potential roles of class VIII myosins and membrane-tethering proteins in controlling viral functions at specific ER subdomains, such as cortical microtubule-associated ER sites, ER-plasma membrane contact sites, and PD...
October 3, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29036553/two-track-control-of-cellular-machinery-for-photomovement-in-spirogyra-varians-streptophyta-zygnematales
#8
Ji Woong Lee, Gwang Hoon Kim
Plants and freshwater algae devoid of flagella evolved various photomovements to optimize their photosynthetic efficiency. The filaments of Spirogyra varians exhibit complex swaying and undulating movement and form a compact mat which enables them to adjust their light exposure. Photomovement of filament fragments (1-10 cells) was analyzed using various photoreceptor and cytoskeleton inhibitors under monochromatic light. Different patterns of movement were observed under red and blue light. The filaments showed positive phototropism under blue light...
September 27, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29035721/cdc42-is-essential-for-the-polarized-movement-and-adhesion-of-human-dental-pulp-stem-cells
#9
Mingwei Li, Liang Ma, Bing Song, Dingyi Yu, Min Xiao, Xiaohan Mei, Huihui Guo, Qing Yu
OBJECTIVE: Stem cell-based tissue repair and regeneration require the regulation of cell migration and adhesion. As a regulator of cell polarization, Cdc42 (cell division control protein 42) plays a basic role at the initial stage of cell migration and adhesion. This study explores the effect of Cdc42 on the polarized migration and adhesion of hDPSCs (human dental pulp stem cells). DESIGN: HDPSCs were isolated from extracted third molars and transfected with siRNA targeted against Cdc42...
October 3, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29035502/binding-mechanism-of-model-charged-dye-carboxyfluorescein-to-hyaluronan-polylysine-multilayers
#10
Vladimir Z Prokopovic, Anna S Vikulina, David Sustr, Elena M Shchukina, Dmitry G Shchukin, Dmitry V Volodkin
Biopolymer-based multilayers become more and more attractive due to the vast span of biological application they can be used for, e.g. implant coatings, cell culture supports, scaffolds. Multilayers have demonstrated superior capability to store enormous amount of small charged molecules such as drugs and release them in a controlled manner, however, the binding mechanism for drug loading into the multilayers is still poorly understood. Here we focus on this mechanism using model hyaluronan/polylysine (HA/PLL) multilayers and a model charged dye carboxyfluorescein (CF)...
October 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29035220/robot-training-with-vector-fields-based-on-stroke-survivors-individual-movement-statistics
#11
Zachary A Wright, Emily Lazzaro, Kelly O Thielbar, James L Patton, Felix C Huang
The wide variation in upper extremity motor impairments among stroke survivors necessitates more intelligent methods of customized therapy. However, current strategies for characterizing individual motor impairments are limited by the use of traditional clinical assessments (e.g. Fugl-Meyer) and simple engineering metrics (e.g. goal-directed performance). Our overall approach is to statistically identify the range of volitional movement capabilities, and then apply a robot-applied force vector field intervention that encourages under-expressed movements...
October 16, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29035218/interacting-with-robots-to-investigate-the-bases-of-social-interaction
#12
Alessandra Sciutti, Giulio Sandini
Humans show a great natural ability at interacting with each other. Such efficiency in joint actions depends on a synergy between planned collaboration and emergent coordination, a subconscious mechanism based on a tight link between action execution and perception. This link supports phenomena as mutual adaptation, synchronization and anticipation, which cut drastically the delays in the interaction and the need of complex verbal instructions and result in the establishment of joint intentions, the backbone of social interaction...
October 16, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29033970/spermine-regulates-pollen-tube-growth-by-modulating-ca-2-dependent-actin-organization-and-cell-wall-structure
#13
Iris Aloisi, Giampiero Cai, Claudia Faleri, Lorella Navazio, Donatella Serafini-Fracassini, Stefano Del Duca
Proper growth of the pollen tube depends on an elaborate mechanism that integrates several molecular and cytological sub-processes and ensures a cell shape adapted to the transport of gametes. This growth mechanism is controlled by several molecules among which cytoplasmic and apoplastic polyamines. Spermine (Spm) has been correlated with various physiological processes in pollen, including structuring of the cell wall and modulation of protein (mainly cytoskeletal) assembly. In this work, the effects of Spm on the growth of pear pollen tubes were analyzed...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29033273/current-techniques-of-teaching-and-learning-in-bariatric-surgical-procedures-a-systematic-review
#14
Mirjam Kaijser, Gabrielle van Ramshorst, Bart van Wagensveld, Jean-Pierre Pierie
OBJECTIVE: The gastric sleeve resection and gastric bypass are the 2 most commonly performed bariatric procedures. This article provides an overview of current teaching and learning methods of those techniques in resident and fellow training. DESIGN: A database search was performed on Pubmed, Embase, and the Education Resources Information Center (ERIC) to identify the methods used to provide training in bariatric surgery worldwide. After exclusion based on titles and abstracts, full texts of the selected articles were assessed...
October 12, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29032444/modulating-signaling-networks-by-crispr-cas9-mediated-transposable-element-insertion
#15
REVIEW
Luis María Vaschetto
In a recent past, transposable elements (TEs) were referred to as selfish genetic components only capable of copying themselves with the aim of increasing the odds of being inherited. Nonetheless, TEs have been initially proposed as positive control elements acting in synergy with the host. Nowadays, it is well known that TE movement into host genome comprises an important evolutionary mechanism capable of increasing the adaptive fitness. As insights into TE functioning are increasing day to day, the manipulation of transposition has raised an interesting possibility of setting the host functions, although the lack of appropriate genome engineering tools has unpaved it...
October 14, 2017: Current Genetics
https://www.readbyqxmd.com/read/29032013/the-presence-of-depression-and-anxiety-do-not-distinguish-between-functional-jerks-and-cortical-myoclonus
#16
R Zutt, J M Gelauff, M Smit, J C van Zijl, J Stone, M A J Tijssen
INTRODUCTION: Functional movement disorders are accompanied by a high occurrence of psychopathology and cause serious impairments in quality of life. However, little is known about this in patients with functional jerks and no comparison has been made between patients with functional jerks and organic myoclonus. This case control study compares the occurrence of depression, anxiety and quality of life (HR-QoL) in patients with functional jerks and cortical myoclonus. METHODS: Patients with functional jerks and cortical myoclonus, consecutively recruited, were compared on self-rated anxiety (Beck Anxiety Inventory), depression (Beck Depression Inventory), health-related quality of life (RAND-36), and myoclonus severity (UMRS and CGI-S rating scales)...
September 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29031998/dominant-foot-could-affect-the-postural-control-in-vestibular-neuritis-perceived-by-dynamic-body-balance
#17
Tomoe Yoshida, Toshitake Tanaka, Yuya Tamura, Masahiko Yamamoto, Mitsuya Suzuki
During attacks of vestibular neuritis (VN), patients typically lose postural balance, with resultant postural inclination, gait deviation toward the lesion side, and tendency to fall. In this study, we examined and analyzed static and dynamic postural control during attacks of VN to characterize differences in postural control between right and left VN. Subjects were patients diagnosed with VN at the Department of Otolaryngology, Toho University Sakura Medical Center, and underwent in-patient treatment. Twenty-five patients who had spontaneous nystagmus were assessed within 3days after the onset; all were right-foot dominant...
October 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29031761/reduced-p300-amplitude-during-a-visuospatial-attention-task-in-idiopathic-rapid-eye-movement-sleep-behavior-disorder
#18
Jung-Ick Byun, Byeong Uk Lee, Minah Kim, Jun-Sang Sunwoo, Jung-Ah Lim, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Man-Ho Kim, Min Hee Jeong, Kwang Su Cha, Jeong Woo Choi, Kyung Hwan Kim, Sang Kun Lee, Ki-Young Jung
OBJECTIVES: Idiopathic rapid eye movement sleep behavior disorder (IRBD) patients are prone to cognitive deficits, which include attention, executive, and visuospatial dysfunctions. Even patients with normal cognition may exhibit subclinical electrophysiological dysfunction. This study aimed to evaluate visuospatial attention processing in IRBD patients with normal cognition and to compare their findings with those of age- and sex-matched healthy controls. METHODS: We recorded event-related potentials (ERPs) and performance measures during a variant of the Posner task in 14 IRBD patients and 14 control subjects...
October 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29031752/sleep-and-slow-wave-activity-in-depressed-adolescent-boys-a-preliminary-study
#19
Olena Santangeli, Tarja Porkka-Heiskanen, Jussi Virkkala, Anu E Castaneda, Mauri Marttunen, Tiina Paunio, Anna S Urrila
OBJECTIVE: Adolescence is a vulnerable period of life that is characterized by increasing incidence of depression. Sleep disturbance is one of the diagnostic symptoms of depressive disorder. Adolescence is also characterized by dramatic maturational changes in sleep and its regulation. The goal of this study was to assess sleep macroarchitecture and slow-wave activity (SWA) in depressed adolescent boys. METHODS: Eight non-medicated adolescent boys meeting the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for depressive disorder and 10 age-matched healthy controls (average age 16...
October 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29031745/sleep-architecture-in-patients-with-juvenile-myoclonic-epilepsy
#20
Jaidaa F Mekky, Sonia M Elbhrawy, Mohamed F Boraey, Horeya M Omar
AIM: The aim is to analyze the sleep architecture using polysomnography (PSG) in patients with Juvenile Myoclonic Epilepsy (JME): (newly diagnosed and those on valproate drug) attending epilepsy clinic at Alexandria University Hospitals. METHODS: This study involved 20 patients with JME on valproate (age: 22.40 ± 5.80 years; M:F = 6:14), 20 newly diagnosed patients (age: 18.55 ± 6.0 years; M:F = 6:14), and 20 matched healthy controls (age: 22.10 ± 5...
October 2017: Sleep Medicine
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