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https://www.readbyqxmd.com/read/29666348/testosterone-levels-and-the-genetic-variation-of-sex-hormone-binding-globulin-gene-of-bubalus-bubalis-bulls-in-egypt
#1
Samy Naeem, Ahmed Ghoneim, Gamal Abd-Allah, Omaima Hassan
Testosterone is themain plasma androgen produced and secreted by male testis. To be bioactive, it binds to sex hormonebinding globulin (SHBG), i.e. the major transporter protein of sex steroids in the blood of mammals and other vertebrate species.Firstly, this study aimed to determine the levels of testosterone in different-age groups of buffalo bulls (Bubalus bubalis) in Egypt, and secondly to screen the genetic polymorphisms in their SHBG gene and to investigatewhether these polymorphisms are associated with the level of the circulating serum testosterone...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29665928/-clinical-characteristics-treatment-and-prognosis-of-ptld-after-allogeneic-hematopoietic-stem-cell-transplantation
#2
Zhan-Xiang Liu, Wen-Rong Huang, Meng Li, Zhen-Yang Gu, Cheng-Ying Zhu, Ning Lu, Sheng Yao, Shu-Hong Wang, Fei Li, Xiao-Ning Gao, Dai-Hong Liu, Chun-Ji Gao
OBJECTIVE: To study the clinical characteristics of patients with post-transplantation lymphoproliferative disease (PTLD) after allogeneic peripheral blood hematopoietic stem cell transplantation, and to improve the understanding and diagnosis of PTLD. METHODS: The clinical data of 244 patients underwent allogeneic hematopoietic stem cell transplantation in the General Hospital of PLA from May 2014 to April 2017 were analyzed retrospectively. The follow-up time was up to November 30, 2017...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665142/risk-factors-for-late-onset-hypogonadism
#3
Q T Yang, K S Wu, Z J Li, W C Li, L Lu, H Q Wu, Y Y Zhuang, X X Sui
The European Male Aging Study (EMAS) has recently defined strict diagnostic criteria for late-onset hypogonadism (LOH) including the levels of serum total testosterone (TT), free testosterone (FT) and three sexual symptoms. However, there is no report on risk factors for LOH using these criteria. In this study, we investigated risk factors for LOH based on these criteria. We recruited 277 men (aged 36-80 years) who completed both a health check-up and two questionnaires (a health and lifestyle questionnaire, and a sexual function questionnaire)...
April 17, 2018: Andrologia
https://www.readbyqxmd.com/read/29665038/safety-and-feasibility-of-outpatient-rabbit-antithymocyte-globulin-induction-therapy-administration-in-kidney-transplant-recipients
#4
Alexandra N Varga, David Johnson, Deirdre L Sawinski, Mary Ann Lim, Roy D Bloom, Peter L Abt, Simin Goral, Melissa Bleicher, Matthew H Levine, Ali Naji, Susanna Nazarian, Paige Porrett, Jennifer Trofe-Clark
BACKGROUND: Kidney transplant induction therapy often includes inpatient administration of rabbit antithymocyte globulin (rATG) over multiple days. To reduce hospital length of stay (LOS) and drug expenditures, the rATG induction course was completed in the outpatient setting via peripheral intravenous administration. The present study assesses early readmission trends ascribable to an outpatient rATG administration protocol to assure initial reduction in hospital LOS is sustained early after discharge...
April 17, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29664663/effects-of-probiotic-supplementation-on-hormonal-profiles-biomarkers-of-inflammation-and-oxidative-stress-in-women-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#5
Maryam Karamali, Sara Eghbalpour, Sajad Rajabi, Mehri Jamilian, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi, Fariba Keneshlou, Seyyed Mehdi Mirhashemi, Maryam Chamani, Sara Hashem Gelougerdi, Zatollah Asemi
BACKGROUND: To the best of our knowledge, data on effects of probiotic administration on hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome (PCOS) are scarce. This investigation was conducted to assess the effects of probiotic supplementation on hormonal profiles, biomarkers of inflammation and oxidative stress in women with PCOS. METHODS: This randomized, double-blind, placebo-controlled trial was conducted on 60 women with PCOS, aged 18-40 years old...
January 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29664567/memory-control-by-the-b-cell-antigen-receptor
#6
REVIEW
Niklas Engels, Jürgen Wienands
The generation of memory B cells (MBCs) that have undergone immunoglobulin class switching from IgM, which dominates primary antibody responses, to other immunoglobulin isoforms is a hallmark of immune memory. Hence, humoral immunological memory is characterized by the presence of serum immunoglobulins of IgG subtypes known as the γ-globulin fraction of blood plasma proteins. These antibodies reflect the antigen experience of B lymphocytes and their repeated triggering. In fact, efficient protection against a previously encountered pathogen is critically linked to the production of pathogen-specific IgG molecules even in those cases where the primary immune response required cellular immunity, for example, T cell-mediated clearance of intracellular pathogens such as viruses...
May 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29661208/unmanipulated-haploidentical-in-comparison-with-matched-unrelated-donor-stem-cell-transplantation-in-patients-60-years-and-older-with-acute-myeloid-leukemia-a-comparative-study-on-behalf-of-the-alwp-of-the-ebmt
#7
Nicole Santoro, Myriam Labopin, Federica Giannotti, Gerard Ehninger, Dietger Niederwieser, Arne Brecht, Matthias Stelljes, Nicolaus Kröger, Herman Einsele, Matthias Eder, Michael Hallek, Bertram Glass, Jürgen Finke, Fabio Ciceri, Mohamad Mohty, Annalisa Ruggeri, Arnon Nagler
BACKGROUND: Acute myeloid leukemia (AML) is both more common and with more biologically aggressive phenotype in the elderly. Allogenic stem cell transplantation (allo-SCT) is the best treatment option in fit patients. Either HLA-matched unrelated donor (MUD) or haploidentical (Haplo) donor are possible alternative for patients in need. METHODS: We retrospectively compared non-T-cell-depleted Haplo (n = 250) to 10/10 MUD (n = 2589) in AML patients ≥ 60 years...
April 16, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29660970/inflammation-and-rehabilitation-outcomes-in-patients-with-nontraumatic-intracranial-haemorrhage
#8
Mirella Boselli, Roberto Aquilani, Roberto Maestri, Maria Pia Achilli, Nadia Arrigoni, Evasio Pasini, Anna Maria Condino, Federica Boschi, Maurizia Dossena, Daniela Buonocore, Manuela Verri
BACKGROUND: Systemic inflammation and its impact on rehabilitation for patients with non-traumatic haemorrhagic injury (HBI) sequelae has not yet been adequately documented. OBJECTIVE AND METHODS: We therefore considered 31 patients with HBI, to determine the serum levels of inflammatory markers (C-Reactive Protein, CRP and or interleukine-6, IL-6) to establish their impact on functional status (Functional Independence Measure, FIM: 18 indicating the worst performance and 126, a normal score)...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29659830/genome-wide-association-study-identifies-nine-novel-loci-for-2d-4d-finger-ratio-a-putative-retrospective-biomarker-of-testosterone-exposure-in-utero
#9
Nicole M Warrington, Enisa Shevroja, Gibran Hemani, Pirro G Hysi, Yunxuan Jiang, Adam Auton, Cindy G Boer, Massimo Mangino, Carol A Wang, John P Kemp, George McMahon, Carolina Medina-Gomez, Martha Hickey, Katerina Trajanoska, Dieter Wolke, Arfan M Ikram, Grant W Montgomery, Janine F Felix, Margaret J Wright, David A Mackey, Vincent W Jaddoe, Nicholas G Martin, Joyce Y Tung, George Davey Smith, Craig E Pennell, Tim D Spector, Joyce van Meurs, Fernando Rivadeneira, Sarah E Medland, David M Evans
The ratio of the length of the index finger to that of the ring finger (2D:4D) is sexually dimorphic and is commonly used as a noninvasive biomarker of prenatal androgen exposure. Most association studies of 2D:4D ratio with a diverse range of sex-specific traits have typically involved small sample sizes and have been difficult to replicate, raising questions around the utility and precise meaning of the measure. In the largest genome-wide association meta-analysis of 2D:4D ratio to date (N = 15,661, with replication N = 75,821), we identified eleven loci (nine novel) explaining 3...
April 12, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29658833/gonadopenia-and-aging-in-men
#10
Sandeep Singh Dhindsa, Michael S Irwig, Kathleen Wyne
OBJECTIVE: The decrease in testosterone levels that occurs with aging has become an important clinical issue both due to the growth of the geriatric population and patient interest in testosterone therapy. The decision to assess for testosterone deficiency and the ability to determine whether the benefits exceed the risks require a comprehensive evaluation of the aging patient. This article is part of a series of papers focused on the endocrinology of aging. This review addresses common issues needed for clinical decision making, including how to interpret test results, differential diagnosis, potential impact of testosterone treatment on insulin resistance and cardiovascular disease, and options for therapy...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29657700/misleading-hepatitis-b-serology-following-rho-d-immune-globulin-human-injection-and-influenza-vaccine
#11
Xuanxuan Chen
Having a hepatitis B surface antibody (HBsAb) titre of more than 10 mIU/mL after hepatitis B vaccination is generally considered to confer immunity to hepatitis B. This case report discusses an unusual case of a false positive hepatitis B core total antibody (HBcAb) following administration of either Rho (D) immune globulin (Human) injection or influenza vaccine in a patriuent who was previously immunised against hepatitis B.
March 28, 2018: Clinics and Practice
https://www.readbyqxmd.com/read/29657001/accuracy-of-a-diagnostic-model-based-on-serum-biochemical-parameters-in-detecting-cows-at-an-increased-risk-of-chronic-fascioliasis
#12
Sławomir J Kowalczyk, Michał Czopowicz, Corinna N Weber, Elisabeth Müller, Jarosław Kaba
In adult cattle Fasciola hepatica infection usually follows a chronic subclinical course, and reduces both the milk yield and milk quality, resulting in considerable financial losses. Effective control of the disease is based on reliable identification of asymptomatically infected individuals, which now requires special parasitological or serological diagnostic tests. It is also known that F. hepatica infection induces alterations in some serum biochemical parameters. Therefore, the study was conducted to develop a model based on serum biochemical parameters allowing to identify cows at higher risk of chronic fascioliasis...
April 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29651025/cardiac-eccentric-remodeling-in-patients-with-rheumatoid-arthritis
#13
Valeria Pascale, Rosa Finelli, Rocco Giannotti, Enrico Coscioni, Raffaele Izzo, Francesco Rozza, Dario Caputo, Paolo Moscato, Guido Iaccarino, Michele Ciccarelli
It is known that patients with rheumatoid arthritis (RA) have a higher risk of coronary heart disease and sudden cardiac death. Abnormalities in cardiac geometry appear to be involved in the setting of the cardiovascular risk, but it has never been specifically investigated in RA. We enrolled 44 patients with RA compared to 131 subjects without RA (normal, N): The RA aged between 18 and 70 years (mean 48.3 ± 2.1), 25 females, BMI 27.6 ± 0.9; N, of equal age (48.6 ± 1.2, n.s.), included 80 females (BMI 26...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650916/-a-case-of-sigmoid-colon-cancer-with-idiopathic-thrombocytopenic-purpura
#14
Kingo Kashimoto, Kenichiro Fukuda, Yosuke Kamada, Nobuki Yamaoka
An 80-year-old man reported at our hospital with the chiefcomplaint ofconstipation. He was diagnosed with sigmoid colon cancer(T4aN0M0, Stage II). He also had steroid-resistant idiopathic thrombocytopenic purpura(ITP)since 2001. After a high dose g-globulin therapy, he underwent sigmoidectomy and splenectomy simultaneously because ofthe steroidresistant ITP. While some reports suggest that ITP is dominant when it occurs with blood cancer, others suggest that it can be immunologically dominant even when it occurs with solid tumors...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29649996/the-effects-of-synbiotic-supplementation-on-hormonal-status-biomarkers-of-inflammation-and-oxidative-stress-in-subjects-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#15
Khadijeh Nasri, Mehri Jamilian, Elham Rahmani, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi, Zatollah Asemi
BACKGROUND: To our knowledge, no reports are available indicating the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome (PCOS). This research was done to assess the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with PCOS. METHODS: This randomized double-blind, placebo-controlled trial was conducted on 60 subjects diagnosed with PCOS according to the Rotterdam criteria...
April 12, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29644918/assessment-of-clinical-sepsis-associated-biomarkers-in-a-septic-mouse-model
#16
Jin-Ling Li, Ge Li, Xi-Zhong Jing, Yun-Feng Li, Qiu-Ying Ye, Huan-Huan Jia, Shu-Hua Liu, Xue-Jiao Li, Hang Li, Ren Huang, Yu Zhang, Hui Wang
Objective Clinical sepsis-associated biomarkers were utilized in a cecal ligation and puncture (CLP) septic mouse model to provide a reference for investigating pathophysiological mechanisms and evaluating novel therapeutic interventions for sepsis. Methods Sepsis in mice was induced by CLP, and clinical biomarkers were evaluated (survival rate, blood physiological and biochemical indices, cytokines, hepatorenal function parameters, and blood coagulation). Results The mortality rate was >70%. The body temperature, blood pressure, and heart rate decreased within 48 h...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29629624/identification-of-the-7s-and-11s-globulins-as-percutaneously-sensitizing-soybean-allergens-as-demonstrated-through-epidermal-application-of-crude-soybean-extract
#17
Hiroki Murakami, Takashi Ogawa, Akiho Takafuta, Erika Yano, Nobuhiro Zaima, Tatsuya Moriyama
Cutaneous exposure to food allergens can predispose individuals to food allergies. Soybean, a major allergenic food, is an ingredient in various cosmetic products. However, the types of soybean proteins that are percutaneously sensitizing in humans or animal models remain unknown. In this study, BALB/c mice were dorsally shaved and epicutaneously exposed to a crude soybean extract including sodium dodecyl sulfate or distilled water alone. Specific IgEs secreted in response to 7S globulin (Gly m 5), 11S globulin (Gly m 6), Gly m 3, and Gly m 4 were measured using enzyme-linked immunosorbent assays or immunoblots...
April 8, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29622092/hematology-and-serum-biochemistry-parameters-of-captive-chinese-alligators-alligator-sinensis-during-the-active-and-hibernating-periods
#18
Fei Peng, Xianxian Chen, Ting Meng, En Li, Yongkang Zhou, Shengzhou Zhang
The Chinese alligator Alligator sinensis is an endangered freshwater crocodilian species endemic to China. Hematology and serum biochemistry reference range are useful in the assessment and management of animal health condition. In this study, a total of 74 Chinese Alligators (30 males and 44 females) were examined to establish reference range values of hematology and serum biochemistry parameters during the active and hibernating periods. We measured and analyzed 9 hematology and 21 serum biochemistry parameters including 4 serum electrolyte parameters, and described the morphology of different types of blood cells...
April 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29621063/posttransplant-cyclophosphamide-for-hla-haploidentical-transplantation-in-patients-with-mucopolysaccharidosis
#19
Yan Yue, Zeliang Song, Junhui Li, Shunqiao Feng, Rong Liu, Xiaodong Shi
We successfully used a haploidentical transplantation protocol with posttransplant cyclophosphamide (CY) (50 mg/kg/d on days +3 and +4) for in vivo T-cell depletion in patients with mucopolysaccharidosis using reduced-intensive conditioning regimens, followed by a busulfan-based conditioning regimen, which included busulfan (12 to 16 mg/kg) and fludarabine(150 to 200 mg/m)+rabbit antihuman thymocyte globulin (7.5 to 10 mg/kg) as a conditioning regimen. Cyclosporine or tacrolimus, methotrexate, mycophenolate mofetil, and methylprednisolone were administered to prevent graft-versus-host disease (GVHD)...
April 4, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29620676/hepatitis-associated-aplastic-anemia-treated-successfully-with-antithymocyte-globulin
#20
Hongyan Ji, Li Chen, Xiaojun Sun, Xiuli Li, Wei Chen, Ping Zhao, Yulin Wang
Hepatitis-associated aplastic anemia (HAAA) is a variant of acquired aplastic anemia in which bone marrow failure follows the development of an acute episode of seronegative hepatitis. HAAA occurs most frequently in male children and is lethal if left untreated. Antilymphocyte globulin, antithymocyte globulin, and allogeneic bone marrow transplantation have been used in the treatment of this disease. In this work, we report the case of a 3-year-old boy with HAAA treated successfully with immunosuppressive therapy...
April 3, 2018: Journal of Pediatric Hematology/oncology
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