Nicole M Warrington, Enisa Shevroja, Gibran Hemani, Pirro G Hysi, Yunxuan Jiang, Adam Auton, Cindy G Boer, Massimo Mangino, Carol A Wang, John P Kemp, George McMahon, Carolina Medina-Gomez, Martha Hickey, Katerina Trajanoska, Dieter Wolke, Arfan M Ikram, Grant W Montgomery, Janine F Felix, Margaret J Wright, David A Mackey, Vincent W Jaddoe, Nicholas G Martin, Joyce Y Tung, George Davey Smith, Craig E Pennell, Tim D Spector, Joyce van Meurs, Fernando Rivadeneira, Sarah E Medland, David M Evans
The ratio of the length of the index finger to that of the ring finger (2D:4D) is sexually dimorphic and is commonly used as a noninvasive biomarker of prenatal androgen exposure. Most association studies of 2D:4D ratio with a diverse range of sex-specific traits have typically involved small sample sizes and have been difficult to replicate, raising questions around the utility and precise meaning of the measure. In the largest genome-wide association meta-analysis of 2D:4D ratio to date (N = 15,661, with replication N = 75,821), we identified eleven loci (nine novel) explaining 3...
April 12, 2018: Human Molecular Genetics