keyword
https://read.qxmd.com/read/38287417/is-blinding-in-studies-of-manual-soft-tissue-mobilisation-of-the-back-possible-a-feasibility-randomised-controlled-trial-with-swiss-graduate-students
#21
RANDOMIZED CONTROLLED TRIAL
Javier Muñoz Laguna, Emanuela Nyantakyi, Urmila Bhattacharyya, Kathrin Blum, Matteo Delucchi, Felix Karl-Ludwig Klingebiel, Marco Labarile, Andrea Roggo, Manuel Weber, Thomas Radtke, Milo A Puhan, Cesar A Hincapié
STUDY DESIGN: Single-centre, two-parallel group, methodological randomised controlled trial to assess blinding feasibility. BACKGROUND: Trials of manual therapy interventions of the back face methodological challenges regarding blinding feasibility and success. We assessed the feasibility of blinding an active manual soft tissue mobilisation and control intervention of the back. We also assessed whether blinding is feasible among outcome assessors and explored factors influencing perceptions about intervention assignment...
January 29, 2024: Chiropractic & Manual Therapies
https://read.qxmd.com/read/38273701/trends-in-clinical-characteristics-medication-use-and-glycemic-control-in-insulin-treated-patients-with-type-1-and-type-2-diabetes-in-finland-in-2012-2019-nationwide-real-world-evidence-study
#22
JOURNAL ARTICLE
Leo Niskanen, Minna Hannula, Kai Kysenius, Saara Kaijala, Mariann I Lassenius, Timo T Valle
AIMS: To describe the clinical characteristics and medication purchases of insulin-treated adults in Finland at index (January 1, 2012 or first insulin purchase) and December 31, 2019. Additionally, to describe basal insulin (BI) treatment patterns and associated changes in hemoglobin A1c (HbA1c) values. MATERIALS AND METHODS: In this descriptive study using nationwide registries, we included adults with at least two reimbursed insulin purchases within 12 months of the first purchase between January 1, 2012 and December 31, 2019...
January 25, 2024: Journal of Diabetes
https://read.qxmd.com/read/38263269/confirmatory-factor-analysis-and-gender-invariance-of-persian-version-of-the-modified-yale-food-addiction-scale-mpyfas-2-0-insight-from-a-large-scale-iranian-sample
#23
JOURNAL ARTICLE
Mohammad Niroumand Sarvandani, Masoud Asadi, Balal Izanloo, Maryam Soleimani, Faezeh Mahdavi, Ashley N Gearhardt, Qing-Wei Chen, Nasrin Ghadiri Varzaneh, Roya Taghadosiniya, Hamed Ghazvini, Maryam Khoramrooz, Raheleh Rafaiee
BACKGROUND: The Modified Yale Food Addiction Scale 2.0 (mYFAS 2.0) was developed with the primary objective of evaluating food addiction (FA). The present study aimed to undertake the translation, pilot testing, and evaluation of the psychometric properties of the mYFAS 2.0 within the Persian-speaking population. METHODS: The transcultural adaptation of the mYFAS 2.0 to the Persian language was conducted. Data collection was carried out through an anonymous online questionnaire...
January 23, 2024: Journal of Eating Disorders
https://read.qxmd.com/read/38257373/effects-of-chalcogen-atoms-on-excited-state-double-proton-transfer-behavior-for-3-6-bis-4-5-dihydroxyoxazo-2-yl-benzene-1-2-diol-derivatives-a-computational-investigation
#24
JOURNAL ARTICLE
Dapeng Yang, Chang Liu, Meiyi Zhang, Jinfeng Zhao
The impact of the chalcogen atomic electronegativity (O, S, and Se atoms) of new organic molecules on excited-state dynamical reactions is self-evident. Inspired by this kind of distinguished photochemical characteristic, in this work, we performed a computational investigation of chalcogen-substituted 3,6-bis(4,5-dihydroxyoxazo-2-yl)benzene-1,2-diol (BDYBD) derivatives (i.e., BDYBD-O, BDYBD-S, and BDYBD-Se). In this paper, we pay close attention to characteristic BDYBD derivatives that contain intramolecular double hydrogen bonds (O1-H2···N3 and O4-H5···N6)...
January 17, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38256420/exploring-the-effectiveness-of-biological-therapy-in-patients-with-psoriasis-body-image-and-quality-of-life
#25
JOURNAL ARTICLE
Chia-Lien Wu, Ya-Ching Chang, Wen-Teng Yao, Tsay-I Chiang
Background and Objectives : Psoriasis is a chronic, long-term, incurable skin inflammatory disease characterized by the excessive proliferation of epidermal keratinocytes, dilation of blood vessels, thickening of the skin, and the formation of visible red patches of variable sizes. The impact on patients differs with the severity of the disease, leading to physiological discomfort and psychological distress, which significantly affect the quality of life. The etiology of psoriasis is not completely clear, but immune cells, including type 1 and type 17 cytokine-producing cells modulated by regulatory T cells (Tregs), play a critical role in driving the disease pathogenesis...
January 15, 2024: Medicina
https://read.qxmd.com/read/38256304/monitored-anesthesia-care-in-minimally-invasive-spine-surgery-a-retrospective-case-series-study
#26
JOURNAL ARTICLE
Hyo Jin Kim, Seongho Park, Yunhee Lim, Si Ra Bang
Background and Objectives: Minimally invasive spine surgery (MISS) under monitored anesthesia care (MAC) has emerged as a treatment modality for spinal radiculopathy. It is essential to secure the airway and guarantee spontaneous respiration without endotracheal intubation during MISS in a prone position. Materials and Methods: To evaluate the feasibility and safety of MAC with dexmedetomidine during MISS, we retrospectively reviewed clinical cases. A retrospective review of medical records was conducted between September 2015 and June 2016...
December 26, 2023: Medicina
https://read.qxmd.com/read/38250722/a-novel-non-invasive-nociceptive-monitoring-approach-fit-for-intracerebral-surgery-a-retrospective-analysis
#27
JOURNAL ARTICLE
Robert Ruemmler, Veselina Moravenova, Sandy Al-Butmeh, Kimiko Fukui-Dunkel, Eva-Verena Griemert, Alexander Ziebart
BACKGROUND: Measuring depth of anesthesia during intracerebral surgery is an important task to guarantee patient safety, especially while the patient is fixated in a Mayfield-clamp. Processed electro-encephalography measurements have been established to monitor deep sedation. However, visualizing nociception has not been possible until recently and has not been evaluated for the neurosurgical setting. In this single-center, retrospective observational analysis, we routinely collected the nociceptive data via a nociception level monitor (NOL® ) of 40 patients undergoing intracerebral tumor resection and aimed to determine if this monitoring technique is feasible and delivers relevant values to potentially base therapeutic decisions on...
2024: PeerJ
https://read.qxmd.com/read/38248717/dimeric-3-5-bis-benzylidene-4-piperidones-tumor-selective-cytotoxicity-and-structure-activity-relationships
#28
JOURNAL ARTICLE
Swagatika Das, Praveen K Roayapalley, Hiroshi Sakagami, Naoki Umemura, Dennis K J Gorecki, Mohammad Hossain, Masami Kawase, Umashankar Das, Jonathan R Dimmock
Background: The objective of this study is to find novel antineoplastic agents that display greater toxicity to malignant cells than to neoplasms. In addition, the mechanisms of action of representative compounds are sought. This report describes the cytotoxicity of a number of dimers of 3,5-bis(benzylidene)-4-piperidones against human malignant cells (promyelocytic leukemia HL-60 and squamous cell carcinoma HSC-2, HSC-3, and HSC-4). Methods: Tumor specificity was evaluated by the selectivity index (SI), that is the ratio of the mean CC50 for human non-malignant oral cells (gingival fibroblasts, pulp cells, periodontal ligament fibroblasts) to that for malignant cells...
January 11, 2024: Medicines (Basel, Switzerland)
https://read.qxmd.com/read/38239522/correlating-the-depth-of-sedation-between-the-ramsay-sedation-scale-and-bispectral-index-using-either-intravenous-midazolam-or-intravenous-propofol-in-elderly-patients-under-spinal-anaesthesia
#29
JOURNAL ARTICLE
Abhinav Sachdeva, Sofia Jaswal, Harsimran S Walia, Y K Batra
BACKGROUND: Supplementation of spinal anaesthesia with sedatives or anxiolytics has emerged as a standard protocol to alleviate patients' anxiety and to produce amnesia during the surgical procedure. Thus, judicious use of sedation can make surgeries under spinal anaesthesia more comfortable and acceptable for the elderly patient, the surgeon, and the anaesthesiologist. However, over-sedation may jeopardise the safety of the patient. Appropriate sedation helps reduce physiological stress, which leads to a better result...
December 2023: Curēus
https://read.qxmd.com/read/38238270/comparison-of-fracture-resistance-between-implant-supported-bis-acryl-interim-3-unit-fdps-using-six-different-strengthening-mechanisms-an-in-vitro-study
#30
JOURNAL ARTICLE
Mohammad Rayyan, Mohamed Sayed, Ali Mohammad Hujeiry, Ghada Ayash
AIM: To investigate six different strengthening mechanisms for three-unit implant-supported provisional restorations. MATERIALS AND METHODS: Six techniques of provisional fixed prostheses (PFP) reinforcement were investigated and were assigned to different groups ( n = 10): group (ZP) zirconia powder, group (SK8) silk thread wrapped as a figure-of-8 pattern around middle third of abutment, group (RC8) size 00 retraction cord wrapped as a figure-of-8 pattern around middle third of abutment, group (RF8) Resin impregnated glass fiber ribbon wrapped as a figure-of-8 pattern around abutment, group (KV8) Kevlar 29 cord wrapped as a figure-of-8 pattern around middle third of abutment, group (KV) Kevlar 29 strands incorporated in resin mix...
November 1, 2023: Journal of Contemporary Dental Practice
https://read.qxmd.com/read/38231845/antioxidant-capacity-of-free-and-peptide-tryptophan-residues-determined-by-the-orac-oxygen-radical-absorbance-capacity-assay-is-modulated-by-radical-radical-reactions-and-oxidation-products
#31
JOURNAL ARTICLE
Juan David Figueroa, Noreima Barroso-Torres, Marcela Morales, Bárbara Herrera, Mario Aranda, Eva Dorta, Camilo López-Alarcón
The ORAC (Oxygen Radical Absorbance Capacity) assay is commonly employed for determining the antioxidant capacity of bioactive peptides. To gain insights into the meaning of this index for peptides containing a single Trp, we studied the consumption of this residue and fluorescein (FLH, the probe of ORAC method), induced by radicals generated by AAPH (2,2'-Azo-bis(2-amidinopropane) dihydrochloride) thermolysis. ORAC values were rationalized from kinetics and computational calculations of bond dissociation energies (BDE) of the N-H bond (indole ring of Trp)...
December 2, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38231656/prevalence-of-poor-body-image-and-its-correlation-with-self-esteem-and-depression-in-middle-aged-women
#32
JOURNAL ARTICLE
R Satwik, D Sinha, B Tiwari
OBJECTIVE: This study aimed to determine the prevalence and predictors of poor body image and its influence on low self-esteem and depression in middle-aged women. METHODS: The study was a cross-sectional survey of 372 women using a predesigned online questionnaire. Main outcome measures were mean scores on the nine-point body image scale (BIS) and prevalence of poor body image (BIS ≥ 10). Significant sociodemographic, physical and mental health predictors of BIS ≥ 10 were established using logistic regression analysis...
January 17, 2024: Climacteric: the Journal of the International Menopause Society
https://read.qxmd.com/read/38227287/a-gis-approach-for-groundwater-quality-evaluation-with-entropy-method-and-fluoride-exposure-with-health-risk-assessment
#33
JOURNAL ARTICLE
Aftab Alam, Amit Kumar, Anshuman Singh
This study used the entropy water quality index to analyse the suitability of groundwater for human consumption as well as the hazard index to identify the probable non-carcinogenic dangers among children, women, and men in Nawada, Bihar (India). A total of 75 groundwater samples were taken from hand pumps and tube/bore wells in the pre-monsoon of 2017, and they were evaluated for various physicochemical characteristics. The region's groundwater major cations and anions are dominated by Ca2+  > Mg2+ and [Formula: see text] > Cl- > [Formula: see text]  > NO3 -  > F > [Formula: see text]...
January 16, 2024: Environmental Geochemistry and Health
https://read.qxmd.com/read/38215709/depth-of-anesthesia-and-nociception-monitoring-current-state-and-vision-for-2050
#34
REVIEW
Pascal Laferrière-Langlois, Louis Morisson, Sean Jeffries, Catherine Duclos, Fabien Espitalier, Philippe Richebé
Anesthesia objectives have evolved into combining hypnosis, amnesia, analgesia, paralysis, and suppression of the sympathetic autonomic nervous system. Technological improvements have led to new monitoring strategies, aimed at translating a qualitative physiological state into quantitative metrics, but the optimal strategies for depth of anesthesia (DoA) and analgesia monitoring continue to stimulate debate. Historically, DoA monitoring used patient's movement as a surrogate of awareness. Pharmacokinetic models and metrics, including minimum alveolar concentration for inhaled anesthetics and target-controlled infusion models for intravenous anesthesia, provided further insights to clinicians, but electroencephalography and its derivatives (processed EEG; pEEG) offer the potential for personalization of anesthesia care...
February 1, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38188080/physicochemical-properties-of-yanggaeng-with-added-tempeh-powder
#35
JOURNAL ARTICLE
Amelly, Jisu Lee, Hyunsoo Jang, Dahyun Kang, Inyong Kim, Jung-Heun Ha
In this study, we investigated the physicochemical and antioxidative properties of the traditional Korean confectionery, Yanggaeng, when various amounts of tempeh powder (TP) were added. We replaced a portion of the white bean paste in Yanggaeng with TP at percentages of 0% (CON), 2% (TP2), 4% (TP4), and 6% (TP6) by total weight. The proximate composition results showed that TP6 exhibited the highest crude ash and crude protein contents, but its moisture content and carbohydrate content were the lowest compared to the CON...
December 31, 2023: Preventive Nutrition and Food Science
https://read.qxmd.com/read/38183420/phototoxicity-of-cyclometallated-ir-iii-complexes-bearing-a-thio-bis-benzimidazole-ligand-and-its-monodentate-analogue-as-potential-pdt-photosensitisers-in-cancer-cell-killing
#36
JOURNAL ARTICLE
Marta Martínez-Alonso, Callum G Jones, James D Shipp, Dimitri Chekulaev, Helen E Bryant, Julia A Weinstein
Two novel cyclometallated iridium(III) complexes have been prepared with one bidentate or two monodentate imidazole-based ligands, 1 and 2, respectively. The complexes showed intense emission with long lifetimes of the excited state. Femtosecond transient absorption experiments established the nature of the lowest excited state as 3 IL state. Singlet oxygen generation with good yields (40% for 1 and 82% for 2) was established by detecting 1 O2 directly, through its emission at 1270 nm. Photostability studies were also performed to assess the viability of the complexes as photosensitizers (PS) for photodynamic therapy (PDT)...
January 6, 2024: Journal of Biological Inorganic Chemistry: JBIC
https://read.qxmd.com/read/38178016/effects-of-adding-low-dose-esketamine-to-sufentanil-and-propofol-sedation-during-cervical-conization-a-single-centre-randomized-controlled-trial
#37
JOURNAL ARTICLE
Jiguo Si, Xiaomin Li, Yuqi Wang, Nianhai Feng, Min Cui
BACKGROUND: Cervical conization is a brief but painful procedure that can be performed under sufficient sedation with propofol and opioids. However, this sedation approach comes with a high risk of sedation-related adverse events (SRAEs). Esketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, causes less cardiorespiratory depression than opioids. The aim of this study was to assess the efficacy and safety of adding a low dose of esketamine to propofol and sufentanil sedation as an opioid-reduced regimen...
January 4, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38165145/efficacy-of-remimazolam-tosilate-versus-propofol-for-total-intravenous-anaesthesia-in-urological-surgery-a-randomised-clinical-trial
#38
RANDOMIZED CONTROLLED TRIAL
Hongmeng Lan, Huiyu Cao, Susu Liu, Xiaofang Gong, Xiaofang Huang, Heng Rong, Bing Xu, Huihe Chen, Ziyin Jiao, Yuliu Lin, Xuehai Guan
BACKGROUND: Remimazolam is a novel ultra-short-acting benzodiazepine sedative that acts on the gamma-aminobutyric acid type A receptor (GABAAR). OBJECTIVE: To compare the efficacies of remimazolam (RMZ), and propofol (PROP) combined with remifentanil and cisatracurium for total intravenous anaesthesia (TIVA) in patients undergoing urological surgery. DESIGN: A prospective, single-blind, randomised, noninferiority clinical trial. SETTING: Single centre from 1 January 2022 to 30 March 2022...
March 1, 2024: European Journal of Anaesthesiology
https://read.qxmd.com/read/38164612/hyphenation-of-lipophilic-ruthenium-ii-diphosphine-core-with-5-fluorouracil-an-effective-metallodrug-against-glioblastoma-brain-cancer-cells
#39
JOURNAL ARTICLE
Abhijit Saha, Indranil Mondal, Anuj Kumari, Avinash Kumar Sonkar, Ramranjan Mishra, Ritu Kulshreshtha, Ashis K Patra
Glioblastoma multiforme (GBM) is the most common highly aggressive malignant brain tumor, with a very limited chance for survival post-diagnosis and post-treatment. Despite significant advancement in GBM genomics implicated in molecularly targeted chemotherapies, the prognosis remains poor and requires new drug discovery approaches. We used fluoropyrimidine 5-fluorouracil (5-FU), an antimetabolite anticancer drug conjugated or 'caged' within a lipophilic Ru(II)-diphosphine (dppe) core formulated as [RuII (dppe)2 (5-FU)]PF6 (Ru-DPPE-5FU), where dppe = 1,2-bis(diphenylphosphino)ethane, and evaluated its in vitro cytotoxicity in depth with aggressive GBM cells (LN229)...
January 2, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38163932/dihydrophenanthrene-open-shell-singlet-diradicals-and-their-roles-in-the-mallory-photocyclization-reaction
#40
JOURNAL ARTICLE
Elliott B Hulley, Edward L Clennan
A computational study (ωB97X-D/6-31G(d)) of the Mallory photocyclization reaction has revealed that the well-established dihydrophenanthrene (DHP) intermediates can adopt either closed-shell (CS) or open-shell-diradical (OS) singlet ground states. A detailed study of the properties of DHPs allowed their classifications as OS, borderline-OS, borderline-CS, or CS intermediates. The triplet electronic state and higher energy CS* isomer of all the OS singlet diradicals were computationally located, and the expected relationship between the diradical index, y o , and the triplet energy and the OS-CS* energy gaps was established...
January 1, 2024: Journal of the American Chemical Society
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