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https://www.readbyqxmd.com/read/28918427/safety-of-monitored-anesthesia-care-using-propofol-based-sedation-for-pleuroscopy
#1
Erik Vakil, Mona Sarkiss, David Ost, Macarena R Vial, Roberto F Casal, Georgie A Eapen, Horiana B Grosu
BACKGROUND: The optimal approach to sedation for pleuroscopy remains undefined. Propofol is the favored sedative-hypnotic for many proceduralists but has a narrow therapeutic window and the risk for oversedation is high. Propofol-based sedation administered by anesthesiologists and the routine use of end-tidal capnography and bispectral index (BIS) monitoring may attenuate risks of complications. OBJECTIVES: The purpose of our study was to evaluate the safety and efficacy of monitored anesthesia care for pleuroscopy...
September 16, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28900195/genetic-interactions-with-age-sex-body-mass-index-and-hypertension-in-relation-to-atrial-fibrillation-the-afgen-consortium
#2
Lu-Chen Weng, Kathryn L Lunetta, Martina Müller-Nurasyid, Albert Vernon Smith, Sébastien Thériault, Peter E Weeke, John Barnard, Joshua C Bis, Leo-Pekka Lyytikäinen, Marcus E Kleber, Andreas Martinsson, Henry J Lin, Michiel Rienstra, Stella Trompet, Bouwe P Krijthe, Marcus Dörr, Derek Klarin, Daniel I Chasman, Moritz F Sinner, Melanie Waldenberger, Lenore J Launer, Tamara B Harris, Elsayed Z Soliman, Alvaro Alonso, Guillaume Paré, Pedro L Teixeira, Joshua C Denny, M Benjamin Shoemaker, David R Van Wagoner, Jonathan D Smith, Bruce M Psaty, Nona Sotoodehnia, Kent D Taylor, Mika Kähönen, Kjell Nikus, Graciela E Delgado, Olle Melander, Gunnar Engström, Jie Yao, Xiuqing Guo, Ingrid E Christophersen, Patrick T Ellinor, Bastiaan Geelhoed, Niek Verweij, Peter Macfarlane, Ian Ford, Jan Heeringa, Oscar H Franco, André G Uitterlinden, Uwe Völker, Alexander Teumer, Lynda M Rose, Stefan Kääb, Vilmundur Gudnason, Dan E Arking, David Conen, Dan M Roden, Mina K Chung, Susan R Heckbert, Emelia J Benjamin, Terho Lehtimäki, Winfried März, J Gustav Smith, Jerome I Rotter, Pim van der Harst, J Wouter Jukema, Bruno H Stricker, Stephan B Felix, Christine M Albert, Steven A Lubitz
It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent studies (131,441 individuals, including 5,722 with AF)...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899924/relationship-between-ugt1a9-gene-polymorphisms-efficacy-and-safety-of-propofol-in-induced-abortions-among-a-chinese-population-a-population-based-study
#3
Ying-Bin Wang, Rong-Zhi Zhang, Sheng-Hui Huang, Shu-Bao Wang, Jian-Qin Xie
This study aimed to investigate the influence of UGT1A9 gene polymorphisms on the efficacy of propofol in patients undergoing the painless induced abortion method. A total of 156 women seeking voluntary pregnancy termination procedures were selected for the study, and subsequently underwent painless induced abortions, following anesthesia by means of propofol administration. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to detect the polymorphisms of UGT1A9 gene at -440C/T, -1818C/T and -1887T/G loci...
September 12, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28899891/effect-of-anesthesia-depth-on-postoperative-clinical-outcome-in-patients-with-supratentorial-tumor-depth-study-protocol-for-a-randomized-controlled-trial
#4
Qianyu Cui, Yuming Peng, Xiaoyuan Liu, Bo Jia, Jia Dong, Ruquan Han
INTRODUCTION: Recent studies have shown that deep anaesthesia is associated with poor outcomes. However, no randomised controlled trials have been conducted to test the causality in patients undergoing brain tumour resection. METHODS AND ANALYSIS: DEPTH is a multicenter, randomised, parallel-group, blind trial. The depth of general anaesthesia will be monitored using the bispectral index (BIS). Patients elected for supratentorial tumour resection will be randomly allocated to the deep or the light anaesthesia group in which the target BIS value is 35 or 50, respectively...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28879332/anesthetic-management-for-simultaneous-drug-induced-sleep-endoscopy-and-maxillomandibular-advancement-in-a-patient-with-obstructive-sleep-apnea
#5
Tae Seong Kuk, Eunsun So, Myong-Hwan Karm, Jimin Kim, Seong In Chi, Hyun Jeong Kim, Kwang-Suk Seo, Sung Woon On, Jin-Young Choi
Drug-induced sleep endoscopy (DISE) is used to identify areas of upper airway obstruction, which occurs when patients with obstructive sleep apnea (OSA) snore. DISE enables effective diagnosis and appropriate treatment of the obstruction site. Among surgical treatment methods for OSA, maxillomandibular advancement surgery (MMA) is performed to move a jaw forward; the surgery has a high success rate for OSA treatment. In DISE, anesthetics such as propofol and midazolam must be administered to induce snoring while the patient is deeply sedated for an accurate diagnosis to be made...
March 2017: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28875137/risk-factor-analysis-of-additional-administration-of-sedative-agent-and-patient-dissatisfaction-in-intravenous-conscious-sedation-using-midazolam-for-third-molar-extraction
#6
Dong-Whan Shin, Jin-Yong Cho, Yoon-Sic Han, Hye-Young Sim, Hee-Sun Kim, Da-Un Jung, Ho Lee
OBJECTIVES: The primary purpose of this study was to investigate the factors related with additional administration of sedative agent during intravenous conscious sedation (IVS) using midazolam (MDZ). The secondary purpose was to analyze the factors affecting patient satisfaction. MATERIALS AND METHODS: Clinical data for 124 patients who had undergone surgical extraction of mandibular third molar under IVS using MDZ were retrospectively investigated in this case-control study...
August 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28869564/phenolics-isolated-from-aframomum-meleguta-enhance-proliferation-and-ossification-markers-in-bone-cells
#7
Ashraf B Abdel-Naim, Abdullah A Alghamdi, Mardi M Algandaby, Fahad A Al-Abbasi, Ahmed M Al-Abd, Hossam M Abdallah, Ali M El-Halawany, Masao Hattori
Osteoporosis is a serious health problem characterized by decreased bone mineral density and deterioration of bone microarchitecture. Current antiosteoporotic agents exhibit a wide range of adverse effects; meanwhile, phytochemicals are effective and safer alternatives. In the current work, nine compounds belonging to hydroxyphenylalkane and diarylheptanoid groups were isolated from Aframomum meleguea seeds and identified as 6-gingerol (1), 6-paradol (2), 8-dehydrogingerdione (3), 8-gingerol (4), dihydro-6-paradol (5), dihydrogingerenone A (6), dihydrogingerenone C (7), 1,7-bis(3,4-dihydroxy-5-methoxyphenyl)heptane-3,5-diyl diacetate (8), and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(3,4-dihydroxyphenyl)heptane-3,5-diyl diacetate (9)...
September 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28858130/effect-of-bispectral-index-guided-anesthesia-on-consumption-of-anesthetics-and-early-postoperative-cognitive-dysfunction-after-liver-transplantation-an-observational-study
#8
Ying-Hao Cao, Ping Chi, Yan-Xing Zhao, Xi-Chen Dong
The objective of this study was to summarize the incidence of postoperative cognitive dysfunction (POCD) after 7days following liver transplantation (LT), and to evaluate the effectiveness of bispectral index (BIS) guided anesthetic intervention in reducing POCD. Additional serum concentrations of S100β and neuron-specific enolase (NSE) were detected during surgery to determine whether they were reliable predictors of POCD.Patients who underwent LT at Beijing YouAn Hospital Affiliated to Capital University of Medical Science from January 2014 to December 2015 were enrolled...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28856525/effect-of-personality-traits-on-adherence-with-positive-airway-pressure-therapy-in-obstructive-sleep-apnea-patients
#9
Ahmet Sinan Copur, D Erik Everhart, Chao Zhang, Zhengjia Chen, Haris Shekhani, Sipan Mathevosian, James Loveless, Eric Watson, Imtiazali Kadri, Leandra Wallace, Edwin Simon, Ashok M Fulambarker
PURPOSE: Patient adherence with positive airway pressure (PAP) therapy is a significant clinical problem in obstructive sleep apnea treatment. Personality traits may be a factor for non-adherence. The aim of this study is to investigate the relationship between PAP therapy adherence and patient personality traits. METHODS: Patients were screened and recruited during their visit to a sleep clinic. Baseline data were collected from each patient's electronic chart...
August 30, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28856114/total-intravenous-anesthesia-for-neurosurgical-procedures-in-narcoleptic-patients-two-case-reports
#10
Sara Pedrosa, Nuno Lareiro, Pedro Amorim
INTRODUCTION: Narcoleptic patients may be at increased risk of prolonged emergence, postoperative hypersomnia, apneic episodes, and sleep paralysis after general anesthesia. Modafinil is the first-line treatment, however, the implication it has on general anesthesia is not clear. This report present 2 cases of narcoleptic patients medicated with modafinil that were submitted to total intravenous anesthesia for neurosurgical procedures. CASE PRESENTATION: Informed consent was obtained from both patients...
June 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28854538/dexmedetomidine-pharmacokinetic-pharmacodynamic-modelling-in-healthy-volunteers-1-influence-of-arousal-on-bispectral-index-and-sedation
#11
P J Colin, L N Hannivoort, D J Eleveld, K M E M Reyntjens, A R Absalom, H E M Vereecke, M M R F Struys
Background: Dexmedetomidine, a selective α 2 -adrenoreceptor agonist, has unique characteristics, such as maintained respiratory drive and production of arousable sedation. We describe development of a pharmacokinetic-pharmacodynamic model of the sedative properties of dexmedetomidine, taking into account the effect of stimulation on its sedative properties. Methods: In a two-period, randomized study in 18 healthy volunteers, dexmedetomidine was delivered in a step-up fashion by means of target-controlled infusion using the Dyck model...
August 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28844933/early-detection-of-brain-death-using-the-bispectral-index-bis-in-patients-treated-by-extracorporeal-cardiopulmonary-resuscitation-e-cpr-for-refractory-cardiac-arrest
#12
Romain Jouffroy, Lionel Lamhaut, Alexandra Guyard, Pascal Philippe, Kim An, Christian Spaulding, Frédéric Baud, Pierre Carli, Benoît Vivien
BACKGROUND: Despite increasing use of extracorporeal cardiopulmonary resuscitation (E-CPR) for treatment of refractory cardiac arrest patients, prognosis remains dismal, often resulting in brain-death. However, clinical assessment of brain-death occurence is difficult in post-cardiac arrest patients, sedated, paralyzed, under mild therapeutic hypothermia (MTH). Our objective was to assess the usefulness of Bispectral-Index (BIS) monitoring at bedside for an early detection of brain-death occurrence in refractory cardiac arrest patients treated by E-CPR...
August 24, 2017: Resuscitation
https://www.readbyqxmd.com/read/28844350/high-incidence-of-body-image-dissatisfaction-in-pregnancy-and-the-postnatal-period-associations-with-depression-anxiety-body-mass-index-and-weight-gain-during-pregnancy
#13
Chutima Roomruangwong, Buranee Kanchanatawan, Sunee Sirivichayakul, Michael Maes
This study aimed to delineate the prevalence of body image dissatisfaction in pregnant women and parturients in relation to depression and anxiety symptoms. We assessed 126 pregnant women during the third trimester and 2-3days and 4-6weeks after delivery using the Body Image Scale (BIS). Many pregnant participants (34.1%) showed body image dissatisfaction (BIS score ≤3) which was associated with current antenatal depression, severity of depression, a lifetime history of mood disorders, trait anxiety, body mass index (BMI) and weight gain during pregnancy...
October 2017: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/28840160/investigation-of-data-driven-optical-neuromonitoring-approach-during-general-anesthesia-with-sevoflurane
#14
Gabriela Hernandez-Meza, Meltem Izzetoglu, Ahmet Sacan, Michael Green, Kurtulus Izzetoglu
Anesthesia monitoring currently needs a reliable method to evaluate the effects of the anesthetics on its primary target, the brain. This study focuses on investigating the clinical usability of a functional near-infrared spectroscopy (fNIRS)-derived machine learning classifier to perform automated and real-time classification of maintenance and emergence states during sevoflurane anesthesia. For 19 surgical procedures, we examine the entire continuum of the maintenance-transition-emergence phases and evaluate the predictive capability of a support vector machine (SVM) classifier during these phases...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/28830714/bis-benzofuran-thiazolidinone-s-and-bis-benzofuran-thiazinanone-s-as-inhibiting-agents-for-chikungunya-virus
#15
Jih Ru Hwu, Nitesh K Gupta, Shwu-Chen Tsay, Wen-Chieh Huang, Irina C Albulescu, Kristina Kovacikova, Martijn J van Hemert
There are currently still no approved antiviral drugs to treat or prevent chikungunya virus (CHIKV) infections despite the fact that this arbovirus continues to cause outbreaks in Africa, Asia, and South- and Central-America. Thus 20 new conjugated compounds in the families of bis(benzofuran-1,3-thiazolidin-4-one)s and bis(benzofuran-1,3-thiazinan-4-one)s were designed based on the structural features of suramin. These new compounds were synthesized by chemical methods and their structures were confirmed spectroscopically...
August 19, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28830480/recorded-time-periods-of-bispectral-index-values-equal-to-zero-predict-neurological-outcome-after-out-of-hospital-cardiac-arrest
#16
Ward Eertmans, Cornelia Genbrugge, Gilles Haesevoets, Jo Dens, Willem Boer, Frank Jans, Cathy De Deyne
BACKGROUND: Prognostication in out-of-hospital cardiac arrest (OHCA) survivors is often difficult. Recent studies have shown the predictive ability of bispectral index (BIS) monitoring to assist with early neuroprognostication. The aim of this study was to investigate whether characteristics of BIS values equal to zero (BIS 0) (i.e. duration and/or uni- versus bilateral presence) instead of simply their occurrence are better indicators for poor neurological outcome after OHCA by aiming at a specificity of 100%...
August 22, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28828225/quantifying-absolute-glutamate-concentrations-in-nucleus-accumbens-of-prescription-opioid-addicts-by-using-1-h-mrs
#17
Xi-Long Liu, Long Li, Jian-Neng Li, Ji-Hua Tang, Jia-Hui Rong, Bo Liu, Ze-Xuan Hu
INTRODUCTION: The diagnosis of psychoactive substance use disorders has been based primarily on descriptive, symptomatic checklist criteria. In opioid addiction, there are no objective biological indicators specific enough to guide diagnosis, monitor disease status, and evaluate efficacy of therapeutic interventions. Proton magnetic resonance spectroscopy ((1)H MRS) of the brain has potential to identify and quantify biomarkers for the diagnosis of opioid dependence. The purpose of this study was to detect the absolute glutamate concentration in the nucleus accumbens (NAc) of patients with prescription opioid dependence using (1)H MRS, and to analyze its clinical associations...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28813052/mixed-ligand-iridium-iii-complexes-as-photodynamic-anticancer-agents
#18
Yue Zheng, Liang He, Dong-Yang Zhang, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Mao
Many phosphorescent iridium complexes are potent candidates as photodynamic therapeutic agents. In this work, a series of mixed-ligand phosphorescent iridium complexes (Ir1: [Ir(L1)(bpy)Cl](PF6)2; Ir2: [Ir(L1)(ppy)Cl](PF6); Ir3: [Ir(L2)(bpy)Cl](PF6)2; Ir4: [Ir(L2)(ppy)Cl](PF6). L1 = 2,6-bis(2-benzimidazolyl)pyridine; bpy = 2,2'-bipyridine; L2 = 2,6-bis(1-methyl-benzimidazol-2-yl)pyridine; ppy = 2-phenylpyridine) have been synthesized and characterized. These complexes display high luminescence quantum yields and long phosphorescence lifetimes...
August 29, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28806690/occurrence-and-distribution-of-halogenated-flame-retardants-in-an-urban-watershed-comparison-to-polychlorinated-biphenyls-and-organochlorine-pesticides
#19
Qian Wang, Barry C Kelly
Due to restrictions on polybrominated diphenyl ethers (PBDEs), market demand for alternative flame retardants is projected to increase, worldwide. Information regarding the environmental behavior of these compounds is limited. The present study involved field measurements of several alternative halogenated flame retardants (HFRs), along with PBDEs and legacy persistent organic pollutants (POPs) in surface water, bottom sediments and suspended particulate matter (SPM) within a highly urbanized watershed in Singapore...
August 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28794492/unusual-inner-salt-guaiazulene-alkaloids-and-bis-sesquiterpene-from-the-south-china-sea-gorgonian-muriceides-collaris
#20
Pinglin Li, Xiaoling Liu, Hongyan Zhu, Xuli Tang, Xuefeng Shi, Yonghong Liu, Guoqiang Li
Three new guaiazulene alkaloids muriceidines A-C (1-3) and one new bis-sesquiterpene muriceidone A (4), were isolated from the South China Sea gorgonian Muriceides collaris. Muriceidines are the first examples structurally architected by guaiazulene coupling with an inner-salt Δ (1)-pipecolic acid via a unique sp(2) methine-bridged linkage, and the bis-sesquiterpene was comprised by a guaiazulene and a indene units linked through a unprecedented carbon-carbon σ-bond between the high steric bridgehead carbon C-10 of guaiazulene moiety and C-2' of indene moiety...
August 9, 2017: Scientific Reports
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