Michael L Alosco, Micaela White, Carter Bell, Farwa Faheem, Yorghos Tripodis, Eukyung Yhang, Zachary Baucom, Brett Martin, Joseph Palmisano, Kristen Dams-O'Connor, John F Crary, Lee E Goldstein, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Christopher Nowinski, Robert C Cantu, Neil W Kowall, Robert A Stern, Victor E Alvarez, Bertrand Russell Huber, Thor D Stein, Ann C McKee, Jesse Mez
BACKGROUND: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) accumulation. The clinical features associated with CTE pathology are unclear. In brain donors with autopsy-confirmed CTE, we investigated the association of CTE p-tau pathology density and location with cognitive, functional, and neuropsychiatric symptoms. METHODS: In 364 brain donors with autopsy confirmed CTE, semi-quantitative p-tau severity (range: 0-3) was assessed in 10 cortical and subcortical regions...
February 6, 2024: Molecular Neurodegeneration