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vitamin b 12 deficiency

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https://www.readbyqxmd.com/read/29913560/maternal-folic-acid-supplementation-with-vitamin-b-12-deficiency-during-pregnancy-and-lactation-affects-the-metabolic-health-of-adult-female-offspring-but-is-dependent-on-offspring-diet
#1
Amanda M Henderson, Daven C Tai, Rika E Aleliunas, Abeer M Aljaadi, Melissa B Glier, Eric E Xu, Joshua W Miller, C Bruce Verchere, Tim J Green, Angela M Devlin
Epidemiologic studies have reported relationships between maternal high folate and/or low B12 status during pregnancy and greater adiposity and insulin resistance in children. The goal of this study was to determine the effects of maternal folic acid supplementation (10 mg/kg diet), with (50 μg/kg diet) and without B12 , on adult, female offspring adiposity and glucose homeostasis. Female C57BL/6J mice were fed 1 of 3 diets from weaning and throughout breeding, pregnancy, and lactation: control (2 mg/kg diet folic acid, 50 μg/kg diet B12 ), supplemental folic acid with no B12 (SFA-B12 ), or supplemental folic acid with adequate B12 (SFA+B12 )...
April 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29907852/predictors-of-anemia-and-iron-status-at-birth-in-neonates-born-to-women-carrying-multiple-fetuses
#2
Yuan Ru, Eva K Pressman, Ronnie Guillet, Philip J Katzman, Stephen J Bacak, Kimberly O O'Brien
BACKGROUND: Iron (Fe) status of neonates born to women carrying multiple fetuses might be compromised as a consequence of the high prevalence of maternal Fe deficiency and anemia coupled with an increased risk of preterm birth. This study aimed to characterize and identify determinants of anemia in this neonatal population. METHODS: Umbilical cord blood obtained from 183 neonates was utilized to assess hemoglobin (Hb), ferritin (SF), soluble transferrin receptor (sTfR), hepcidin, serum Fe, erythropoietin, folate, vitamin B-12, C-reactive protein, and interleukin-6...
June 15, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29897579/iron-deficiency-anemia-and-low-vitamin-b-12-serostatus-in-middle-childhood-are-associated-with-behavior-problems-in-adolescent-boys-results-from-the-bogot%C3%A3-school-children-cohort
#3
Sonia L Robinson, Constanza Marín, Henry Oliveros, Mercedes Mora-Plazas, Blair J Richards, Betsy Lozoff, Eduardo Villamor
Background: Iron deficiency (ID) in infancy is related to subsequent behavior problems. The effects of micronutrient status in middle childhood are uncertain. Objective: The aim of the study was to examine the associations of micronutrient status biomarkers in middle childhood with externalizing and internalizing behavior problems in adolescence. Methods: We assessed whether ID (ferritin <15 µg/L), anemia (hemoglobin <12.7 g/dL), or blood concentrations of zinc, vitamins A and B-12, and folate at ages 5-12 y were associated with externalizing or internalizing behavior problems in adolescence in 1042 schoolchildren from Bogotá, Colombia...
April 20, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29874929/improved-testing-for-vitamin-b-12-deficiency-correcting-mma-for-egfr-reduces-the-number-of-patients-classified-as-vitamin-b-12-deficient
#4
Saskia Lm van Loon, Anna M Wilbik, Uzay Kaymak, Edwin R van den Heuvel, Volkher Scharnhorst, Arjen-Kars Boer
Background Methylmalonic acid (MMA) can detect functional vitamin B12 deficiencies as it accumulates early when intracellular deficits arise. However, impaired clearance of MMA from blood due to decreased glomerular filtration rate (eGFR) also results in elevated plasma MMA concentrations. Alternative to clinical trials, a data mining approach was chosen to quantify and compensate for the effect of decreased eGFR on MMA concentration. Methods Comprehensive data on patient's vitamin B12 , eGFR and MMA concentrations were collected ( n = 2906)...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29859645/vitamin-b-12-deficiency-induced-neuropathy-secondary-to-prolonged-recreational-use-of-nitrous-oxide
#5
William Egan, Eric Steinberg, Jeremy Rose
A 24-year-old female, otherwise healthy, presented to the Emergency Department (ED) with difficulty walking and bilateral leg pain. The patient was a recreational nitrous oxide (NO2 ) user, also known as "whippets" or simply nitrous. Neurologic examination demonstrated an unsteady gait and positive Romberg sign along with normal deep tendon reflexes and normal muscle strength in upper and lower extremities. Laboratory results demonstrated macrocytic erythropoiesis, reduced B12 , elevated homocysteine, and elevated methylmalonic acid...
May 24, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29848335/feasibility-and-effect-of-life-skills-building-education-and-multiple-micronutrient-supplements-versus-the-standard-of-care-on-anemia-among-non-pregnant-adolescent-and-young-pakistani-women-15-24-years-a-prospective-population-based-cluster-randomized-trial
#6
Jo-Anna B Baxter, Yaqub Wasan, Sajid B Soofi, Zamir Suhag, Zulfiqar A Bhutta
BACKGROUND: Adolescence is a critical period for physical and psychological growth and development, and vitamin and mineral requirements are correspondingly increased. Health and health behaviours correspond strongly from adolescence to adulthood. Developing a preconception care package for adolescent and young women in resource-limited settings could serve to empower them to make informed decisions about their nutrition, health, and well-being, as well as function as a platform for the delivery of basic nutrition-related interventions to address undernutrition...
May 30, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29796870/-clinical-hematological-symptoms-of-vitamin-b-12-deficiency-in-old-age-summarized-overview-of-this-year-s-symposium-of-the-working-group-anemia-in-the-aged-on-the-occasion-of-the-annual-conference-of-the-german-geriatric-society-dgg-in-frankfurt
#7
REVIEW
Gabriele Röhrig, Ines Gütgemann, Gerald Kolb, Andreas Leischker
The interdisciplinary symposium of the working group "anemia in the aged" on the occasion of the annual conference of the German Society of Geriatrics focused this year on vitamin B12 deficiency in aged patients. Experts from hematopathology, clinical geriatrics and geriatric hematology presented the case of a 78-year-old woman and an interdisciplinary discussion was held on the epidemiology, clinical aspects as well as diagnostic and therapeutic steps. This article reviews the symposium on vitamin B12 deficiency in the aged in the context of the currently available literature...
May 23, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29795596/evaluation-of-tracer-labelled-methionine-load-test-in-vitamin-b-12-deficient-adolescent-women
#8
Dattatray S Bhat, Lourdes L Gruca, Carole D Bennett, Prachi Katre, Anura V Kurpad, Chittaranjan S Yajnik, Satish C Kalhan
BACKGROUND: Methionine loading test (MLT) has been used primarily to identify defects in transsulfuration of homocysteine in cystathionine beta synthase deficiency. It may not be as useful to evaluate remethylation pathway, in vitamin B-12 and folate deficiencies. OBJECTIVE: We used tracer isotope labelled MLT to interrogate transsulfuration and remethylation independently in vitamin B-12 deficiency. DESIGN: We studied vitamin B-12 deficient women with a tracer labelled MLT before and eleven months after treatment with vitamin B-12...
2018: PloS One
https://www.readbyqxmd.com/read/29761652/vitamin-d-status-and-associated-genetic-polymorphisms-in-a-cohort-of-uk-children-with-non-alcoholic-fatty-liver-disease
#9
P S Gibson, A Quaglia, A Dhawan, H Wu, S Lanham-New, K H Hart, E Fitzpatrick, J B Moore
BACKGROUND: Vitamin D deficiency has been associated with non-alcoholic fatty liver disease (NAFLD). However, the role of polymorphisms determining vitamin D status remains unknown. OBJECTIVES: The objectives of this study were to determine in UK children with biopsy-proven NAFLD (i) their vitamin D status throughout a 12-month period and (ii) interactions between key vitamin D-related genetic variants (nicotinamide adenine dinucleotide synthase-1/dehydrocholesterol reductase-7, vitamin D receptor, group-specific component, CYP2R1) and disease severity...
May 14, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/29751936/effect-of-vitamin-d-on-the-variability-of-blood-pressure-in-premenopausal-and-menopausal-hypertensive-women-in-the-area-of-blida-algeria
#10
A Bachir Cherif, M Temmar, S Bennouar, A Bouamra, A Taleb, A Bouraghda, M T Bouafia
OBJECTIVE: To evaluate the effect of 25 (OH) vitamin D supplementation on blood pressure (BP) variability in hypertensive women in the pre-menopausal and post-menopausal periods. MATERIALS AND METHODS: 881 hypertensive women prospectively followed for an interventional study between January 2016 and September 2017, in specialized consultation at the department of internal medicine at the Blida University Hospital (Algeria). Four hundred and thiry nine premenopausal women (group I) and 442 menopausal women (group II)...
May 8, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29743793/bone-health-and-impact-of-tenofovir-treatment-in-men-with-hepatitis-b-related-chronic-liver-disease
#11
Kattiparambil G Sajith, Nitin Kapoor, Sahana Shetty, Ashish Goel, Uday Zachariah, Chundamannil E Eapen, Thomas V Paul
Background: Chronic Liver Disease (CLD) has been shown to have an adverse impact on bone health. Hepatitis-B related CLD and its treatment with tenofovir may have additional effects on skeleton. Objective: To study the impact of HBV related CLD and its treatment with Tenofovir on bone health in Indian subjects. Methods: This cross sectional study included men (18-60 years) and comprised of three groups: Group-1 was treatment naïve HBV related CLD ( n  = 79), Group-2 those with HBV related CLD on tenofovir for at least 1 year ( n  = 136), Group-3 age, sex and Body Mass Index (BMI) matched healthy controls ( n  = 58)...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29721404/consequences-of-inadequate-intakes-of-vitamin-a-vitamin-b-12-vitamin-d-calcium-iron-and-folate-in-older-persons
#12
REVIEW
Jessica Watson, Marissa Lee, Maria Nieves Garcia-Casal
Purpose of Review: This review broadly discusses the consequences of inadequate consumption, by deficit or excess, of selected micronutrients on the quality of life and morbidity during aging, specifically considering increases in life expectancy and the costs of care in the older persons. Recent Findings: A literature review of the periods 2012 to 2018, focusing on vitamins A, B12 , and D, calcium, iron and folate, was completed as these micronutrients are found to significantly affect the aging process...
2018: Current Geriatrics Reports
https://www.readbyqxmd.com/read/29721250/congenital-methemoglobinemia-misdiagnosed-as-polycythemia-vera-case-report-and-review-of-literature
#13
Dina Sameh Soliman, Mohamed Yassin
Methemoglobinemia is a rare overlooked differential diagnosis in patients presented with cyanosis and dyspnea unrelated to cardiopulmonary causes. Our patient is 29 year old Indian non-smoker male, his story started 6 months prior to presentation to our center when he had generalized fatigue and discoloration of hands. He presented with persistent polycythemia with elevated hemoglobin level. The patient was misdiagnosed in another center as polycythemia and treated with Imatinib. The diagnosis of PV was revisited and ruled out in view of negative JAK2, normal erythropoietin level and absence of features of panmyelosis...
March 2, 2018: Hematology Reports
https://www.readbyqxmd.com/read/29720136/prevalence-and-predictors-of-under-nutrition-among-school-children-in-a-rural-south-eastern-nigerian-community-a-cross-sectional-study
#14
Rufina N B Ayogu, Ifeoma C Afiaenyi, Edith U Madukwe, Elizabeth A Udenta
BACKGROUND: School children in developing countries like Nigeria are faced with numerous nutrition and health problems. Lack of functional school health and nutrition programmes in Enugu state, Nigeria may be associated with dearth of data on associated factors. Identifying these factors could inform the design and implementation of school-based programmes aimed at ameliorating these problems. METHODS: A cross sectional survey involving 450 primary and secondary school children aged 6-15 years was conducted in Ede-Oballa, a rural community in Enugu state, South-eastern Nigeria...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29695256/metabolic-distress-in-lipid-one-carbon-metabolic-pathway-through-low-vitamin-b-12-a-population-based-study-from-north-india
#15
Kallur Nava Saraswathy, Shipra Joshi, Suniti Yadav, Priyanka Rani Garg
BACKGROUND: Dyslipidemia and hyper-homocysteinemia are the major independent risk factors of cardio vascular disease. Deficiency of folate and vitamin B-12 are associated with both hyper-homocysteinemia and dyslipidemia. The aim of the study is to evaluate the relationship of homocysteine and its associated dietary determinant levels (Folate and Vitamin B-12) with lipids and obesity parameters (WC, BMI, WHR) in North Indian population. METHODS: The participants were recruited under a major government funded project through household survey covering 15 villages of Haryana, India...
April 25, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29643928/effect-of-low-energy-diet-for-eight-weeks-to-adults-with-overweight-or-obesity-on-folate-retinol-vitamin-b-12-d-and-e-status-and-the-degree-of-inflammation-a-post-hoc-analysis-of-a-randomized-intervention-trial
#16
Nina Rica Wium Geiker, Mette Veller, Louise Kjoelbaek, Jette Jakobsen, Christian Ritz, Anne Raben, Arne Astrup, Janne Kunchel Lorenzen, Lesli H Larsen, Susanne Bügel
Background: Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B12 , D and E status and the degree of inflammation. Methods: Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m2 , completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B12 , D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29563097/do-the-benefits-of-folic-acid-fortification-outweigh-the-risk-of-masking-vitamin-b-12-deficiency
#17
(no author information available yet)
No abstract text is available yet for this article.
March 21, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29546304/folate-deficiency-facilitates-genomic-integration-of-human-papillomavirus-type-16-dna-in-vivo-in-a-novel-mouse-model-for-rapid-oncogenic-transformation-of-human-keratinocytes
#18
Suhong Xiao, Ying-Sheng Tang, Praveen Kusumanchi, Sally P Stabler, Ying Zhang, Asok C Antony
Background: Epidemiologic and in vitro studies suggest independent linkages between poor folate and/or vitamin B-12 nutrition, genomic human papillomavirus (HPV) type 16 viral integration, and cancer. However, there is no direct evidence in vivo to support the causative role of poor folate nutrition in HPV16 integration into the cellular genome. Objective: We tested the hypothesis that folate deficiency enables the integration of HPV16 into the genome of HPV16-harboring keratinocytes, and could thereby influence earlier transformation of these cells to cancer in an animal model...
March 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29546303/cobalamin-deficiency-results-in-increased-production-of-formate-secondary-to-decreased-mitochondrial-oxidation-of-one-carbon-units-in-rats
#19
Luke MacMillan, Garrett Tingley, Sara K Young, Kathy A Clow, Edward W Randell, Margaret E Brosnan, John T Brosnan
Background: Formate is produced in mitochondria via the catabolism of serine, glycine, dimethylglycine, and sarcosine. Formate produced by mitochondria may be incorporated into the cytosolic folate pool where it can be used for important biosynthetic reactions. Previous studies from our lab have shown that cobalamin deficiency results in increased plasma formate concentrations. Objective: Our goal was to determine the basis for elevated formate in vitamin B-12 deficiency...
March 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29543316/oral-vitamin-b-12-versus-intramuscular-vitamin-b-12-for-vitamin-b-12-deficiency
#20
REVIEW
Haiyan Wang, Linyi Li, Ling Ling Qin, Yanan Song, Josep Vidal-Alaball, Tong Hua Liu
BACKGROUND: Vitamin B12 deficiency is common, and the incidence increases with age. Most people with vitamin B12 deficiency are treated in primary care with intramuscular (IM) vitamin B12 . Doctors may not be prescribing oral vitamin B12 formulations because they may be unaware of this option or have concerns regarding its effectiveness. OBJECTIVES: To assess the effects of oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, and LILACS, as well as the WHO ICTRP and ClinicalTrials...
March 15, 2018: Cochrane Database of Systematic Reviews
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