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vitamin b 12 deficiency

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https://www.readbyqxmd.com/read/28070764/serum-25-oh-vitamin-d-levels-in-systemic-sclerosis-analysis-of-140-patients-and-review-of-the-literature
#1
Dilia Giuggioli, M Colaci, G Cassone, P Fallahi, F Lumetti, A Spinella, F Campomori, A Manfredi, C U Manzini, A Antonelli, C Ferri
Hypovitaminosis D is increasingly reported in autoimmune diseases. We investigated the 25-OH-vitamin D (25-OH-vitD) levels in systemic sclerosis (SSc) patients, in correlation with disease's features. We measured the 25-OH-vitD serum levels in 140 consecutive patients (F/M 126/15; mean age 61 ± 15.1 years), 91 without (group A) and 49 with (group B) 25-OH-cholecalciferol supplementation. Patients of group A invariably showed low 25-OH-vitD levels (9.8 ± 4.1 ng/ml vs. 26 ± 8.1 ng/ml of group B); in particular, 88/91 (97%) patients showed vitamin D deficiency (<20 ng/ml), with very low vitamin D levels (<10 ng/ml) in 40 (44%) subjects...
January 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28065736/long-term-outcomes-of-bariatric-surgery-in-adolescents-with-severe-obesity-fabs-5-a-prospective-follow-up-analysis
#2
Thomas H Inge, Todd M Jenkins, Stavra A Xanthakos, John B Dixon, Stephen R Daniels, Meg H Zeller, Michael A Helmrath
BACKGROUND: Little is known about the long-term outcomes of bariatric surgery for severe adolescent obesity, raising questions about the durability of early responses to surgery. We aimed to analyse long-term (>5 years) outcomes of Roux-en-Y gastric bypass in a cohort of young adults who had undergone the operation during adolescence, in the Follow-up of Adolescent Bariatric Surgery at 5 Plus Years (FABS-5+) extension study. METHODS: A cohort of young people aged 13-21 years underwent Roux-en-Y gastric bypass for clinically severe obesity at a paediatric academic medical centre in the USA...
January 5, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28065190/cholecalciferol-v-ergocalciferol-for-25-hydroxyvitamin-d-25-oh-d-repletion-in-chronic-kidney-disease-a-randomised-clinical-trial
#3
James B Wetmore, Cassandra Kimber, Jonathan D Mahnken, Jason R Stubbs
Patients with chronic kidney disease (CKD) demonstrate complex mineral metabolism derangements and a high prevalence of vitamin D deficiency. However, the optimal method of 25-hydroxyvitamin D (25(OH)D) repletion is unknown, and trials analysing the comparative efficacy of cholecalciferol and ergocalciferol in this population are lacking. We conducted a randomised clinical trial of cholecalciferol 1250μg (50 000 IU) weekly v. ergocalciferol 1250μg (50 000 IU) weekly for 12 weeks in forty-four non-dialysis-dependent patients with stage 3-5 CKD...
January 9, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28052885/a-micronutrient-fortified-young-child-formula-improves-the-iron-and-vitamin-d-status-of-healthy-young-european-children-a-randomized-double-blind-controlled-trial
#4
Marjolijn D Akkermans, Simone Rbm Eussen, Judith M van der Horst-Graat, Ruurd M van Elburg, Johannes B van Goudoever, Frank Brus
BACKGROUND: Iron deficiency (ID) and vitamin D deficiency (VDD) are common among young European children because of low dietary intakes and low compliance to vitamin D supplementation policies. Milk is a common drink for young European children. Studies evaluating the effect of milk fortification on iron and vitamin D status in these children are scarce. OBJECTIVE: We aimed to investigate the effect of a micronutrient-fortified young-child formula (YCF) on the iron and vitamin D status of young European children...
January 4, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28052884/vitamin-b-12-fortified-toothpaste-improves-vitamin-status-in-vegans-a-12-wk-randomized-placebo-controlled-study
#5
Anne-Kathrin Siebert, Rima Obeid, Stine Weder, Hussain M Awwad, Andreas Sputtek, Juergen Geisel, Markus Keller
BACKGROUND: The oral application of vitamin B-12 may prevent its deficiency if the vitamin is absorbed via the mucosal barrier. OBJECTIVES: We studied the effect of the use of a vitamin B-12-fortified toothpaste on vitamin-status markers in vegans and assessed the efficiency of markers in the identification of vitamin-augmentation status. DESIGN: In this 12-wk, double-blinded, randomized, placebo-controlled study, 76 vegans received either a placebo (n = 34) or vitamin B-12 (n = 42) toothpaste...
January 4, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28045952/predictive-factors-of-one-year-mortality-in-a-cohort-of-patients-undergoing-urgent-start-hemodialysis
#6
Luciene P Magalhães, Luciene M Dos Reis, Fabiana G Graciolli, Benedito J Pereira, Rodrigo B de Oliveira, Altay A L de Souza, Rosa M Moyses, Rosilene M Elias, Vanda Jorgetti
BACKGROUND: Chronic kidney disease (CKD) affects 10-15% of adult population worldwide. Incident patients on hemodialysis, mainly those on urgent-start dialysis at the emergency room, have a high mortality risk, which may reflect the absence of nephrology care. A lack of data exists regarding the influence of baseline factors on the mortality of these patients. The aim of this study was to evaluate the clinical and laboratory characteristics of this population and identify risk factors that contribute to their mortality...
2017: PloS One
https://www.readbyqxmd.com/read/28031376/vitamin-b-6-status-in-unsupplemented-pregnant-women-is-associated-positively-with-serum-docosahexaenoic-acid-and-inversely-with-the-n-6-to-n-3-fatty-acid-ratio
#7
Maria F Mujica-Coopman, Ana B Franco-Sena, Dayana R Farias, Juliana S Vaz, Alex Brito, Gilberto Kac, Yvonne Lamers
BACKGROUND: Vitamin B-6-deficient diets decrease plasma docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (AA) concentrations in healthy adults. These fatty acids (FAs) are important for fetal neurodevelopment, but the relation between vitamin B-6 status and circulating polyunsaturated FAs (PUFAs) during pregnancy is unknown. OBJECTIVE: We sought to assess the relation between plasma pyridoxal 5' phosphate (PLP; the active form of vitamin B-6) and serum DHA, EPA, AA, linoleic acid, eicosadienoic, and α-linolenic acid concentrations during pregnancy...
December 28, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27932751/-a-case-of-subacute-combined-degeneration-caused-by-vitamin-b-sub-12-sub-deficiency-in-a-cervical-spondylosis-surgery-referral
#8
Kunio Yokoyama, Masahiro Kawanishi, Akira Sugie, Makoto Yamada, Hidekazu Tanaka, Yutaka Ito, Toshihiko Kuroiwa
A 62-year-old man with a 1-year history of numbness of the extremities, clumsiness, and gait disorder was diagnosed with cervical spondylotic myelopathy at a neighboring clinic and referred to our institution for surgery. The patient had undergone a total gastrectomy 6 years previously. Flattening of the cervical cord, associated with diffuse cervical spondylosis and intramedullary intensity change, was observed on magnetic resonance imaging of the cervical spine. Neurological examination revealed decreased vibratory and position sense in all limbs, with posterior funiculus-based neurological symptoms...
December 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27920342/experimentally-induced-preterm-birth-in-sheep-following-a-clinical-course-of-antenatal-betamethasone-effects-on-growth-and-long-term-survival
#9
Vivian B Nguyen, Robert De Matteo, Richard Harding, Aneta Stefanidis, Graeme R Polglase, M Jane Black
Preterm births account for approximately 10% of births worldwide, with the majority (∼80%) being moderate preterm. Our aim was to determine the effects of moderate preterm birth on survival and long-term growth of male and female offspring using an ovine model of preterm birth that was preceded by a clinically relevant dose of corticosteroids. Ewes were induced to deliver preterm or at term; those assigned to deliver preterm were administered antenatal betamethasone (11.4 mg, 2 doses, 24 hours apart). The growth (body weight and body dimensions) of offspring was monitored to adulthood (62 weeks) when the animals were humanely killed for organ collection...
December 5, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27874946/visual-and-somotosensory-evoked-potentials-in-asymptomatic-patients-with-vitamin-b12-deficiency
#10
B Gökçe Çokal, H N Güneş, S K Güler, T K Yoldaş
OBJECTIVE: Vitamin B12 deficiency may be asymptomatic or present with a wide range of neurological and hematological disorders. Our aim in this study is to evaluate visual (VEP) and somatosensory evoked potential (SEP) parameters in patients with vitamin B12 deficiency who had no clinical evidence of visual impairment or neurological syndrome findings and compare the findings with healthy controls to determine whether there is a correlation between VEP and SEP parameters and serum vitamin B12 levels...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27863287/bone-health-in-the-elderly-cancer-patient-a-siog-position-paper
#11
REVIEW
J J Body, E Terpos, B Tombal, P Hadji, A Arif, A Young, M Aapro, R Coleman
More than a third of cancers are diagnosed in people over the age of 75. Androgen deprivation for prostate cancer and aromatase inhibitors in breast cancer accelerate age-related bone loss and increase fracture rates. BMD should be checked by dual energy X-ray absorptiometry at baseline and, dependent on risk, every 12-24months. Sufficient calcium, vitamin D and exercise are part of primary fracture prevention. Resistance exercise in particular may improve functional activity and bone density. In men at increased fracture risk and women with postmenopausal early breast cancer, antiresorptive treatment is warranted to reduce fracture rate and to increase overall survival in breast cancer...
December 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27825289/vitamin-d-deficiency-in-traumatic-brain-injury-and-its-relationship-with-severity-of-injury-and-quality-of-life-a-prospective-observational-study
#12
Emma Toman, Jonathon R B Bishop, David J Davies, Zhangjie Su, Sherwin Criseno, Andrea Mason, Andrew A Toogood, Antonio Belli
This single-center prospective observational study aims to describe the prevalence of vitamin D deficiency (VDD) in the traumatic brain injury (TBI) population and identify any relationship between vitamin D and severity of head injury or quality of life. One hundred twenty-four TBI patients had serum vitamin D (25-OHD) levels measured at the local post-TBI endocrine screening clinic over 20 months. Quality of Life after Brain Injury questionnaires were completed by the patient concurrently. A multivariate regressional analysis was performed, controlling for age, season, ethnicity, time since injury, TBI severity, and gender...
December 20, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27756315/serum-folate-predicts-muscle-strength-a-pilot-cross-sectional-study-of-the-association-between-serum-vitamin-levels-and-muscle-strength-and-gait-measures-in-patients-65%C3%A2-years-old-with-diabetes-mellitus-in-a-primary-care-setting
#13
Andrew Kien Han Wee
BACKGROUND: Old age and diabetes mellitus are risk factors for vitamin deficiencies, weakness and falls. Deficiencies of vitamin D, and possibly vitamin B12 and folate (which are associated with hyperhomocysteinaemia), contribute to sarcopenia. Determination of the physical effects of vitamin deficiencies in specific groups of people can help to guide public health policy with regard to vitamin supplementation. METHODS: A pilot cross-sectional study was conducted to determine the association of levels of vitamin D, vitamin B12, folate and homocysteine with muscle strength, gait and fall history in 56 patients >65 years old with diabetes mellitus in primary care in Singapore...
October 18, 2016: Nutrition Journal
https://www.readbyqxmd.com/read/27730081/relationship-of-levels-of-vitamin-d-with-flow-mediated-dilatation-of-brachial-artery-in-patients-of-myocardial-infarction-and-healthy-control-a-case-control-study
#14
Sarthak Malik, Subhash Giri, S V Madhu, Vinita Rathi, B D Banerjee, Nikhil Gupta
BACKGROUND: Cardiovascular diseases (CVD) remain the leading cause of death worldwide. Vitamin D deficiency has been linked to increased risk of adverse CV events. Vitamin D deficiency may be responsible for endothelial dysfunction which in turn affects the onset and progression of coronary artery disease and its risk factors, directly or indirectly through various mechanisms. MATERIALS AND METHODS: It was case-control study. A total of 50 cases of acute myocardial infarction (AMI) (aged 40-60 years), admitted to medicine emergency/CCU, were taken as per ACC/AHA 2007 guidelines...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27728722/hyperpigmentation-an-important-clinical-indicator-for-vitamin-b-12-deficiency
#15
A A Kothari, A L Kakrani
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27727100/the-dietary-quality-of-food-pantry-users-a%C3%A2-systematic-review-of-existing-literature
#16
Anja Simmet, Julia Depa, Peter Tinnemann, Nanette Stroebele-Benschop
Users of food pantries often have a long history of food insecurity and may be vulnerable to nutritional deficiencies. The quality of their diets is not well researched. The purpose of this systematic review was to summarize the published evidence about the dietary quality of food pantry users. Systematic database searches of PubMed, PsycINFO, PsycARTICLES, and Psychology Behavioral Sciences Collection, and hand searches of references were conducted to identify cross-sectional, cohort, and intervention studies reporting baseline data, conducted in high-income countries and published between 1980 and 2015, which reported on the nutritional adequacy of individuals who have used a food pantry at least once in the previous 12 months...
October 7, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27718150/randomized-clinical-trial-to-comparing-efficacy-of-daily-weekly-and-monthly-administration-of-vitamin-d3
#17
István Takács, Béla E Tóth, László Szekeres, Boglárka Szabó, Bence Bakos, Péter Lakatos
The comparative efficacy and safety profiles of selected daily 1000 IU, weekly 7000 IU and monthly 30,000 IU vitamin D 3-not previously investigated-will be evaluated. Here, a prospective, randomized clinical trial, comparing efficacy and safety of a daily single dose of 1000 IU (group A) to a once-weekly 7000 IU dose (group B), or monthly 30,000 IU dose (group C) of vitamin D3. The present study is a controlled, randomized, open-label, multicenter clinical trial, 3  months in duration. Sixty-four adult subjects with vitamin D deficiency (25OHD<20 ng/ml), were included according to the inclusion and exclusion criteria...
October 7, 2016: Endocrine
https://www.readbyqxmd.com/read/27696575/modulatory-effects-of-vitamin-d-on-peripheral-cellular-immunity-in-patients-with-recurrent-miscarriage
#18
Xian Chen, Biao Yin, Ruo-Chun Lian, Tao Zhang, Hong-Zhan Zhang, Liang-Hui Diao, Yu-Ye Li, Chun-Yu Huang, De-Sheng Liang, Yong Zeng
PROBLEM: We aimed to investigate the modulatory effects of vitamin D on peripheral blood cellular immune response in patients with recurrent miscarriage (RM). METHOD OF STUDY: The effect of vitamin D on the number of peripheral blood cells, T helper 1 (Th1) cytokines, and NK cytotoxicity was measured in 99 women with RM. RESULTS: The percentage of CD19(+) B cells and NK cytotoxicity at an effector-to-target cell (E:T) ratio of 50:1, 25:1, and 12...
December 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27693095/clinical-practice-guidelines-for-vitamin-d-in-the-united-arab-emirates
#19
Afrozul Haq, Sunil J Wimalawansa, Pawel Pludowski, Fatme Al Anouti
In the UAE and the Gulf region in general, there are several intricate public health issues in the context of vitamin D deficiency that needs to be addressed. Changes in lifestyle such as diet, lack of exercise, cultural habits, avoiding sun exposure due to excessive heat, and other risk factors predispose those who live in GULF countries, such as Emiratis likely to becoming vitamin D deficient. Consequently, the prevalence of vitamin D deficiency is high, and new guidelines are needed to overcome this major public health issue...
September 28, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27640333/dietary-vitamin-c-deficiency-depressed-the-gill-physical-barriers-and-immune-barriers-referring-to-nrf2-apoptosis-mlck-nf-%C3%AE%C2%BAb-and-tor-signaling-in-grass-carp-ctenopharyngodon-idella-under-infection-of-flavobacterium-columnare
#20
Hui-Jun Xu, Wei-Dan Jiang, Lin Feng, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou
This study explored the effects of vitamin C on the physical barriers and immune barriers, and relative mRNA levels of signaling molecules in the gill of grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare. The results indicated that compared with optimal vitamin C supplementation, vitamin C deficiency (2.9 mg/kg diet) (1) increased reactive oxygen species, malondialdehyde and protein carbonyl (PC) contents (P < 0.05), decreased the copper/zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and mRNA levels (P < 0...
November 2016: Fish & Shellfish Immunology
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