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https://www.readbyqxmd.com/read/27911101/in-vivo-and-ex-vivo-evaluation-of-inflammation-and-apoptosis-induced-after-smile-procedures-for-different-refractive-error-range
#1
Leonardo Mastropasqua, Roberta Calienno, Claudia Curcio, Rodolfo Mastropasqua, Mario Nubile, Niccolò Salgari, Manuela Lanzini
PURPOSE: To detect corneal inflammation and apoptosis induced after small incision lenticule extraction (SMILE) at different refractive corrections for moderate to high values of myopia. METHODS: Fifty patients (50 eyes) suffering from medium to high myopia (spherical equivalent refraction from -3.75 to -10.00 diopters (D) with refractive astigmatism under -0.75 D) underwent SMILE in order to correct myopic error. In vivo evaluation was done by corneal confocal microscopy (IVCM) and ex vivo by immunohistochemistry...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27820631/in-vivo-distribution-of-corneal-epithelial-dendritic-cells-in-patients-with-glaucoma
#2
Rodolfo Mastropasqua, Luca Agnifili, Vincenzo Fasanella, Andrea Lappa, Lorenza Brescia, Manuela Lanzini, Francesco Oddone, Paolo Perri, Leonardo Mastropasqua
Purpose: The purpose of this study was to evaluate dendritic cell (DC) distribution, morphology, and DC density in the entire cornea of medically controlled glaucoma patients (MCGP), using in vivo confocal microscopy (IVCM). Methods: Fifty MCGP were enrolled, 15 patients with dry eye, and 15 healthy subjects served as controls. Patients were asked to complete the Ocular Surface Disease Index (OSDI) questionnaire and then underwent tear film break-up time (BUT), corneal staining, and Schirmer test (ST) I and then IVCM...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27816571/corneal-nerve-and-epithelial-cell-alterations-in-corneal-allodynia-an-in-vivo-confocal-microscopy-case-series
#3
Pedram Hamrah, Yureeda Qazi, Bashar Shahatit, Mohammad H Dastjerdi, Deborah Pavan-Langston, Deborah S Jacobs, Perry Rosenthal
PURPOSE: To investigate the morphological changes of the corneal epithelium and sub-basal nerves in patients with corneal allodynia using in vivo confocal microscopy (IVCM). DESIGN: Case-control study of patients with corneal allodynia and healthy controls. METHODS: Ten eyes of six patients were diagnosed with corneal allodynia at a single center and compared to fifteen healthy eyes. IVCM of the central cornea was performed on all subjects and controls...
November 2, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27813513/comparative-quantitative-assessment-of-the-human-corneal-sub-basal-nerve-plexus-by-in-vivo-confocal-microscopy-and-histological-staining
#4
B S Kowtharapu, K Winter, C Marfurt, S Allgeier, B Köhler, M Hovakimyan, T Stahnke, A Wree, O Stachs, R F Guthoff
PurposeThis study was designed to compare and contrast quantitative data of the human corneal sub-basal nerve plexus (SBP) evaluated by two different methods: in vivo confocal microscopy (IVCM), and immunohistochemical staining of ex vivo donor corneas.MethodsSeven parameters of the SBP in large-scale IVCM mosaicking images from healthy subjects were compared with the identical parameters in ex vivo donor corneas stained by β-III-tubulin immunohistochemistry. Corneal nerve fiber length (CNFL), corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), average weighted corneal nerve fiber tortuosity (CNFTo), corneal nerve connection points (CNCP), average corneal nerve single-fiber length (CNSFL), and average weighted corneal nerve fiber thickness (CNFTh) were calculated using a dedicated, published algorithm and compared...
November 4, 2016: Eye
https://www.readbyqxmd.com/read/27811337/patients-with-multiple-sclerosis-demonstrate-reduced-subbasal-corneal-nerve-fibre-density
#5
Janine Mikolajczak, Hanna Zimmermann, Ahmad Kheirkhah, Ella Maria Kadas, Timm Oberwahrenbrock, Rodrigo Muller, Aiai Ren, Joseph Kuchling, Holger Dietze, Harald Prüss, Friedemann Paul, Pedram Hamrah, Alexander U Brandt
BACKGROUND: Many studies in multiple sclerosis (MS) have investigated the retina. Little, however, is known about the effect of MS on the cornea, which is innervated by the trigeminal nerve. It is the site of neural-immune interaction with local dendritic cells reacting in response to environmental stimuli. OBJECTIVE: This study aims to investigate the effect of MS on corneal nerve fibres and dendritic cells in the subbasal nerve plexus using in vivo confocal microscopy (IVCM)...
November 3, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27800176/anterior-segment-imaging-in-ocular-surface-squamous-neoplasia
#6
REVIEW
Sally S Ong, Gargi K Vora, Preeya K Gupta
Recent advances in anterior segment imaging have transformed the way ocular surface squamous neoplasia (OSSN) is diagnosed and monitored. Ultrasound biomicroscopy (UBM) has been reported to be useful primarily in the assessment of intraocular invasion and metastasis. In vivo confocal microscopy (IVCM) shows enlarged and irregular nuclei with hyperreflective cells in OSSN lesions and this has been found to correlate with histopathology findings. Anterior segment optical coherence tomography (AS-OCT) demonstrates thickened hyperreflective epithelium with an abrupt transition between abnormal and normal epithelium in OSSN lesions and this has also been shown to mimic histopathology findings...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27779170/in-vivo-confocal-microscopy-evaluation-of-meibomian-gland-dysfunction-in-dry-eye-patients-with-different-symptoms
#7
Hui Zhao, Jing-Yao Chen, Yu-Qian Wang, Zhi-Rong Lin, Shen Wang
BACKGROUND: Dry eye patients suffer from all kinds of symptoms. Sometimes, the clinical signs evaluation does not disclose any obvious difference in routine examination; in vivo confocal microscopy (IVCM) is a powerful tool for ocular surface disease. This study aimed to clarify meibomian gland (MG) alterations in dry eye patients with different symptoms and to compare the findings using IVCM. METHODS: A total of sixty patients were recruited, all subjected to Ocular Surface Disease Index (OSDI) and Salisbury Eye Evaluation Questionnaire (SEEQ), and questionnaires for the assessment of dry eye symptoms before clinical sign examinations were given to the patients...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27775242/corneal-confocal-microscopy-alterations-in-sj%C3%A3-gren-s-syndrome-dry-eye
#8
Michele Lanza, Stefania Iaccarino, Gilda Varricchi, Tito D'Errico, Ugo Antonello Gironi Carnevale, Mario Bifani
PURPOSE: To evaluate light backscattering (LB) in corneal layers in patients with primary Sjögren's syndrome dry eye (SSDE) utilizing in vivo corneal confocal microscopy (IVCM) and to determine the eventual association with the lacrimal functional test values. METHODS: A complete ophthalmic evaluation, Schirmer test with and without stimulation, break-up time (BUT) and IVCM were performed on 55 patients affected by SSDE and in an age- and sex-matched cohort of healthy participants (HP)...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27775234/sterile-corneal-infiltrates-after-corneal-collagen-cross-linking-evaluation-of-risk-factors
#9
Eren Çerman, Deniz Özarslan Özcan, Ebru Toker
PURPOSE: To evaluate possible risk factors leading to sterile corneal infiltrates following corneal collagen cross-linking (CXL). METHODS: A total of 588 eyes of 459 patients treated with Epi-off (n = 461) or Epi-on (n = 127) CXL were retrospectively evaluated. Risk factors, including preoperative blepharitis and vernal conjunctivitis, the postoperative use of topical non-steroidal anti-inflammatory drugs (NSAIDs), as well as Kmax and pachymetry measurements, were assessed...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27771327/in-vivo-confocal-microscopy-of-corneal-nerves-in-health-and-disease
#10
Andrea Cruzat, Yureeda Qazi, Pedram Hamrah
In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal physiology and disease. Enabling the dissection of corneal architecture at a cellular level, this technique offers fast and noninvasive in vivo imaging of the cornea with images comparable to that of ex vivo histochemical techniques. Corneal nerves bear substantial relevance to clinicians and scientists alike, given their pivotal roles in regulation of corneal sensation, maintenance of epithelial integrity, and proliferation and promotion of wound healing...
October 19, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27760652/-role-of-in-vivo-confocal-microscopy-in-the-diagnosis-of-keratoconjunctival-tumors
#11
J J Huang, Q F Liang, B Li
The diagnosis of keratoconjunctival tumors were mainly relied on the examination of the slit lamp microscope and histopathology till now. Making an accurate diagnosis to ocular surface tumor in time was very important for deciding the treatment method and evaluating the prognosis. In recent years, in vivo confocal microscopy (IVCM) has been used in ophthalmic clinical diagnosis as a new evaluation method. It was easy to detect cytological characteristics of ocular surface diseases safely in vivo. More and more researches results have shown that IVCM could provide powerful supports to the diagnosis and management of keratoconjunctival tumors, especially for the pigmented tumors and ocular surface squamous neoplasia...
October 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27760648/-study-on-the-evaluation-of-pterygium-activity-with-in-vivo-confocal-microscopy
#12
Q F Liang, C Gao, H Liang, B Li, X H Du, Antoine Labbe
Objective: To observe the characteristics of pterygium with in vivo confocal microscopy (IVCM) and understand pterygium activity with the density of inflammatory cells, formation of new blood vessels, and the number of activated keratocytes within the stroma. Methods: A prospective case-controlled study. Thirty-six pterygia from 28 patients were analyzed in this study. A pterygium activity score was obtained by summing four scores of ocular discomfort, pterygium hyperemia, keratitis, and the presence of Fuchs patches...
October 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27749452/comparative-confocal-and-histopathological-study-of-corneal-changes-in-multiple-myeloma
#13
Antonio Micali, Anna M Roszkowska, Elisa I Postorino, Laura Rania, Emanuela Aragona, Edward Wylegala, Anna Nowinska, Antonio Ieni, Sebastiano Calimeri, Antonina Pisani, Pasquale Aragona, Domenico Puzzolo
PURPOSE: Corneal opacities rarely occur in multiple myeloma (MM). Our study correlates the findings of in vivo confocal microscopy (IVCM), a useful diagnostic tool, with histopathological features of corneal opacities appearing in a patient with MM. METHODS: Case report. RESULTS: A 53-year-old man developed corneal opacities in both eyes, more pronounced in the left eye. After IVCM examination, he underwent penetrating keratoplasty in the left eye, and the button was processed for light and electron microscopy and immunohistochemistry...
October 5, 2016: Cornea
https://www.readbyqxmd.com/read/27749450/morphology-of-the-corneal-limbus-following-standard-and-accelerated-corneal-collagen-cross-linking-9-mw-cm2-for-keratoconus
#14
Ömür Ö Uçakhan, Betül Bayraktutar
PURPOSE: To evaluate the morphological features of the corneal limbus as measured by in vivo confocal microscopy (IVCM) following standard and accelerated corneal collagen cross-linking (CXL) for keratoconus. METHODS: Patients with progressive keratoconus scheduled to undergo standard CXL (group 1; 31 patients, 3 mW/cm, 370 nm, 30 minutes), or accelerated CXL (group 2; 20 patients, 9 mW/cm, 370 nm, 10 minutes) in the worse eye were included in this prospective study...
October 5, 2016: Cornea
https://www.readbyqxmd.com/read/27647244/-in-vivo-confocal-microscopy-evaluation-of-meibomian-glands-in-meibomian-gland-dysfunction-patients
#15
Q F Liang, C Gao, H Liang, X H Du, N L Wang, Antoine Labbe
Objective: To observe the morphology, fibrosis grade and inflammatory infiltration of meibomian glands using in vivo confocal microscopy(IVCM)in meibomian gland dysfunction(MGD)patients. Methods: A prospective case-controlled study. According to the diagnostic criteria of MGD, 20 MGD patients(20 eyes)were included in our study from August to October 2015. Fifteen normal subjects(15 eyes)were also studied. Methods All subjects completed the questionnaire of the Ocular Surface Disease Index(OSDI), lid margin and ocular surface examination by slit lamp microscropy, tear film break-up time(TBUT)test, corneal and conjunctival staining(Oxford scale), Schirmer I test, infrared meibomian photography and IVCM...
September 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27645227/measurement-of-corneal-and-limbal-epithelial-thickness-by-anterior-segment-optical-coherence-tomography-and-in-vivo-confocal-microscopy
#16
Qihua Le, Yan Chen, Yujing Yang, Jianjiang Xu
BACKGROUND: To compare corneal epithelial thickness (CET) and limbal epithelial thickness (LET) measured by anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscope (IVCM) in normal subjects, and evaluate the consistency between them. METHODS: Thirty-eight normal subjects (17 men and 21 women) were enrolled in this study. AS-OCT was performed at central cornea and the superior, inferior, nasal and temporal limbus. Then followed by IVCM examination performed at the same location...
2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27631352/translational-immunoimaging-and-neuroimaging-demonstrate-corneal-neuroimmune-crosstalk
#17
Pedram Hamrah, Yashar Seyed-Razavi, Takefumi Yamaguchi
Corneal immunoimaging and neuroimaging approaches facilitate in vivo analyses of the cornea, including high-resolution imaging of corneal immune cells and nerves. This approach facilitates the analyses of underlying immune and nerve alterations not detected by clinical slit-lamp examination alone. In this review, we describe recent work performed in our translational ocular immunology center with a focus on "bench-to-bedside" and "bedside-to-bench" research. The ability to visualize dendritiform immune cells (DCs) in patients with laser in vivo confocal microscopy (IVCM), recently discovered in the central murine cornea, has allowed us to demonstrate their utility as a potential surrogate biomarker for inflammatory ocular surface diseases...
November 2016: Cornea
https://www.readbyqxmd.com/read/27607414/in-vivo-confocal-microscopy-in-dry-eye-disease-associated-with-chronic-graft-versus-host-disease
#18
Ahmad Kheirkhah, Yureeda Qazi, Michael A Arnoldner, Kunal Suri, Reza Dana
PURPOSE: To compare densities of corneal epithelial dendritic cells (DCs), corneal subbasal nerves, and conjunctival epithelial immune cells (EICs) between patients with dry eye disease (DED) with and without graft-versus-host disease (GVHD) using in vivo confocal microscopy (IVCM). METHODS: This study included 54 patients who had moderate to severe DED either associated with (n = 33) or without (n = 21) chronic GVHD. In addition to evaluating clinical parameters of DED, images obtained by laser-scanning IVCM of the central cornea and superior tarsal conjunctiva were analyzed to measure densities of corneal epithelial DCs, corneal subbasal nerves, and conjunctival EICs...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27585920/in-vivo-confocal-microscopic-observations-of-eyes-diagnosed-with-posterior-corneal-vesicles
#19
Atsushi Shiraishi, Xiaodong Zheng, Yuri Sakane, Yuko Hara, Yasuhito Hayashi
PURPOSE: To determine the morphological characteristics of the cornea in eyes with posterior corneal vesicles (PCV) determined by in vivo confocal microscopy (IVCM). In addition, to compare the morphological characteristics of the corneas of eyes with PCV to those of eyes with posterior polymorphous corneal dystrophy (PPCD). METHODS: Three males and three females aged 17-75 years who were diagnosed with PCV by slit-lamp biomicroscopic findings were studied. The slit-lamp findings, specular microscopic images, corneal endothelial cell densities (CDs), central corneal thickness, and IVCM images were evaluated...
September 1, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27560027/imaging-microscopic-features-of-keratoconic-corneal-morphology
#20
Kate Grieve, Cristina Georgeon, Felipe Andreiuolo, Marie Borderie, Djida Ghoubay, Josette Rault, Vincent M Borderie
PURPOSE: To search for gold-standard histology indicators using alternative imaging modalities in keratoconic corneas. METHODS: Prospective observational case-control study. Fourteen keratoconic corneas and 20 normal corneas (10 in vivo healthy subjects and 10 ex vivo donor corneas) were examined. Images of corneas were taken by spectral domain optical coherence tomography (SD-OCT) and in vivo confocal microscopy (IVCM) before keratoplasty. The same removed corneal buttons were imaged after keratoplasty with full-field optical coherence microscopy (FFOCM) and then fixed and sent for histology...
August 25, 2016: Cornea
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