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https://www.readbyqxmd.com/read/29436059/outcomes-of-penetrating-keratoplasty-following-autologous-cultivated-limbal-epithelial-stem-cell-transplantation
#1
Gustavo S Figueiredo, Borja Salvador-Culla, Oliver J Baylis, Hardeep S Mudhar, Majlinda Lako, Francisco C Figueiredo
PURPOSE: To investigate the outcomes of penetrating keratoplasty (PKP) following autologous cultivated limbal epithelial stem cell transplantation (CLET). METHODS: A prospective, single centre, interventional cohort study investigating patients with unilateral total limbal stem cell deficiency (LSCD) treated with CLET who underwent PKP. Patients with confirmed corneal re-epithelialization > 6 months post-CLET, and with best-corrected visual acuity (BCVA) <0...
February 13, 2018: Stem Cells
https://www.readbyqxmd.com/read/29428226/intravenous-plus-inhaled-versus-intravenous-colistin-monotherapy-for-lower-respiratory-tract-infections-a-systematic-review-and-meta-analysis
#2
REVIEW
Konstantinos Z Vardakas, Andreas D Mavroudis, Maria Georgiou, Matthew E Falagas
OBJECTIVE: To evaluate whether IV plus inhaled combination (IV/INHCC) compared to IV monotherapy (IVCM) was associated with patient outcomes and identify factors influencing study outcomes. METHODS: PubMed and Scopus were searched till November 2016. Studies were included if they evaluated adult patients with lower respiratory tract infections due to MDR/XDR Gram-negative bacteria and reported comparative mortality data (adjusted and unadjusted) for patients receiving IV/INHCC versus IVCM...
February 8, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29412494/the-rising-tide-of-acanthamoeba-keratitis-in-auckland-new-zealand-a-7-year-review-of-presentation-diagnosis-and-outcomes-2009-2016
#3
James McKelvie, Moaz Alshiakhi, Mohammed Ziaei, Dipika V Patel, Charles Nj McGhee
IMPORTANCE: Acanthamoeba is an increasingly prevalent cause of vision-threatening microbial keratitis. BACKGROUND: To assess the incidence, clinical presentation, diagnosis and outcomes of patients with Acanthamoeba keratitis (AK) in Auckland, New Zealand over a 7-year period. DESIGN: Retrospective observational consecutive case series. PARTICIPANTS: Fifty-eight eyes of 52 patients diagnosed with AK. METHODS: All cases of AK were identified using a cross-referenced search of clinical, laboratory and pharmacy records from March 2009 to May 2016...
February 7, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29401160/meibomian-gland-features-and-conjunctival-goblet-cell-density-in-glaucomatous-patients-controlled-with-prostaglandin-timolol-fixed-combinations-a-case-control-cross-sectional-study
#4
Luca Agnifili, Rodolfo Mastropasqua, Vincenzo Fasanella, Lorenza Brescia, Barbara Scatena, Francesco Oddone, Leonardo Mastropasqua
PURPOSE: To investigate, using in vivo confocal microscopy (IVCM), the Meibomian gland (MG) features and conjunctival goblet cell density (GCD) in glaucomatous patients controlled with prostaglandin/timolol fixed combinations (PTFCs). METHODS: In this cross-sectional study, sixty Caucasian patients treated with PTFCs, fifteen with latanoprost+timolol (L+T) unfixed combination, and fifteen controls were enrolled. Patients underwent the Ocular Surface Disease Index (OSDI) questionnaire, tear film break-up time (BUT), corneal staining, Schirmer test I (STI), and IVCM of MGs and goblet cells (GCs)...
February 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29373338/corneal-neurotization-for-neurotrophic-keratopathy-clinical-outcomes-and-in-vivo-confocal-microscopic-and-histopathological-findings
#5
Darren S J Ting, Gustavo S Figueiredo, Christin Henein, Eric Barnes, Omar Ahmed, Hardeep S Mudhar, Francisco C Figueiredo
PURPOSE: To describe the long-term outcomes and in vivo confocal microscopic (IVCM) and histopathological findings after corneal neurotization surgery. METHODS: We included 2 patients who underwent corneal neurotization surgery for severe unilateral neurotrophic keratopathy secondary to cerebellopontine angle meningioma. Corneal sensation was measured using the Cochet-Bonnet esthesiometer (CBE) (0-60 mm). IVCM was performed using the Heidelberg HRT3 Rostock Corneal Module...
January 24, 2018: Cornea
https://www.readbyqxmd.com/read/29322221/feasibility-of-opportunistic-osteoporosis-screening-in-routine-contrast-enhanced-multi-detector-computed-tomography-mdct-using-texture-analysis
#6
M R K Mookiah, A Rohrmeier, M Dieckmeyer, K Mei, F K Kopp, P B Noel, J S Kirschke, T Baum, K Subburaj
This study investigated the feasibility of opportunistic osteoporosis screening in routine contrast-enhanced MDCT exams using texture analysis. The results showed an acceptable reproducibility of texture features, and these features could discriminate healthy/osteoporotic fracture cohort with an accuracy of 83%. INTRODUCTION: This aim of this study is to investigate the feasibility of opportunistic osteoporosis screening in routine contrast-enhanced MDCT exams using texture analysis. METHODS: We performed texture analysis at the spine in routine MDCT exams and investigated the effect of intravenous contrast medium (IVCM) (n = 7), slice thickness (n = 7), the long-term reproducibility (n = 9), and the ability to differentiate healthy/osteoporotic fracture cohort (n = 9 age and gender matched pairs)...
January 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29306088/changes-in-in-vivo-confocal-microscopic-findings-of-ocular-surface-squamous-neoplasia-during-treatment-with-topical-interferon-alfa-2b
#7
Mehran Zarei-Ghanavati, Ebrahim Mousavi, Amin Nabavi, Golshan Latifi, Hadi Z Mehrjardi, Masoomeh Mohebbi, Hamed Ghassemi, Farrin Mirzaie, Mohammad Ali Zare
PURPOSE: To evaluate in vivo confocal microscopy (IVCM) findings of ocular surface squamous neoplasia (OSSN) during treatment with topical interferon alfa-2b (IFN alfa-2b). METHODS: In this prospective interventional case series, 20 eyes from 20 patients with OSSN were treated with topical IFN alfa-2b 3 million IU/mL four times a day. Treatment was continued for 2 or 3 months after clinical resolution. IVCM was done at baseline, on a monthly basis, and at the end of treatment...
January 3, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29305292/corneal-nerve-regeneration-after-herpes-simplex-keratitis-an-in-vivo-confocal-microscopy-study
#8
Hamid-Reza Moein, Ahmad Kheirkhah, Rodrigo T Muller, Andrea C Cruzat, Deborah Pavan-Langston, Pedram Hamrah
PURPOSE: To evaluate the long-term alterations in corneal nerves in patients with herpes simplex virus (HSV) keratitis using in vivo confocal microscopy (IVCM). DESIGN: Prospective longitudinal, cross sectional. METHODS: This study included 16 patients with history of HSV keratitis and 15 age-matched normal controls. Slit-scanning IVCM was performed in all subjects at baseline and then after a mean follow-up of 37.3 ± 1.7 months in the patient group...
January 2, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29303889/factors-influencing-the-diagnostic-accuracy-of-laser-scanning-in-vivo-confocal-microscopy-for-acanthamoeba-keratitis
#9
Ahmad Kheirkhah, Vannarut Satitpitakul, Zeba A Syed, Rodrigo Müller, Sunali Goyal, Elmer Y Tu, Reza Dana
PURPOSE: To determine the factors that influence the sensitivity and specificity of laser-scanning in vivo confocal microscopy (IVCM) for diagnosing Acanthamoeba keratitis (AK). METHODS: This retrospective, controlled study included 28 eyes of 27 patients with AK and 34 eyes of 34 patients with bacterial keratitis (as the control group). All patients had undergone corneal imaging with a laser-scanning IVCM (Heidelberg Retina Tomograph 3 with the Rostock Cornea Module)...
January 4, 2018: Cornea
https://www.readbyqxmd.com/read/29301512/epithelial-changes-with-corneal-punctate-epitheliopathy-in-type-2-diabetes-mellitus-and-their-correlation-with-time-to-healing
#10
Jing-Hao Qu, Li Li, Lei Tian, Xiao-Yu Zhang, Ravi Thomas, Xu-Guang Sun
BACKGROUND: To study basal epithelial cell (BEC), sub-basal nerve plexus (SBN) and Langerhans cell (LC) density in patients with type 2 diabetes mellitus (T2DM) with corneal punctate epitheliopathy (CPE) and to assess their association with time to healing of CPE. METHODS: Retrospective study of in vivo confocal microscopy (IVCM) in 160 eyes from 160 patients with T2DM diagnosed with CPE due to a single cause. Key exclusion criteria included multiple-causes for CPE or treatment with autologous serum...
January 4, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29288723/intravenous-colistin-combination-antimicrobial-treatment-versus-monotherapy-a-systematic-review-and-meta-analysis
#11
REVIEW
Konstantinos Z Vardakas, Andreas D Mavroudis, Maria Georgiou, Matthew E Falagas
BACKGROUND: To evaluate whether IV colistin in combination with other antibiotics (IVCC) was associated with lower mortality compared to colistin monotherapy (IVCM) and identify factors influencing study outcomes. METHODS: PubMed and Scopus were searched till November 2016. Studies were included if they evaluated adult patients with MDR/XDR Gram-negative infections and reported comparative mortality data (adjusted and unadjusted) for patients receiving IVCC versus IVCM...
December 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29242906/reduced-corneal-nerve-fiber-density-in-type-2-diabetes-by-wide-area-mosaic-analysis
#12
Neil S Lagali, Stephan Allgeier, Pedro Guimarães, Reza A Badian, Alfredo Ruggeri, Bernd Köhler, Tor Paaske Utheim, Beatrice Peebo, Magnus Peterson, Lars B Dahlin, Olov Rolandsson
Purpose: To determine if corneal subbasal nerve plexus (SBP) parameters derived from wide-area depth-corrected mosaic images are associated with type 2 diabetes. Methods: One hundred sixty-three mosaics were produced from eyes of 82 subjects by laser-scanning in vivo confocal microscopy (IVCM). Subjects were of the same age, without (43 subjects) or with type 2 diabetes (39 subjects). Mosaic corneal nerve fiber length density (mCNFL) and apical whorl corneal nerve fiber length density (wCNFL) were quantified and related to the presence and duration of diabetes (short duration < 10 years and long duration ≥ 10 years)...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29193851/survival-of-corneal-nerve-sheath-structures-in-organ-cultured-donor-corneas
#13
Virinder K Dhillon, Mohamed S Elalfy, Marco Messina, Mouhamed Al-Aqaba, Harminder S Dua
PURPOSE: To study the morphology of human corneal nerves in eye bank organ-cultured corneas and in corneal grafts post-transplantation. METHODS: Thirty-seven organ-cultured corneas were divided into: Group-A, anterior 300-400 μm of 20 corneas used for Descemets stripping endothelial keratoplasty, and Group-B, 17 full-thickness corneas unsuitable for transplantation. Corneas whole mounts were stained for nerves using acetylcholinesterase technique and examined by NanoZoomer digital pathology microscope...
November 29, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29176786/in-vivo-imaging-of-palisades-of-vogt-in-dry-eye-versus-normal-subjects-using-en-face-spectral-domain-optical-coherence-tomography
#14
COMPARATIVE STUDY
Wajdene Ghouali, Rachid Tahiri Joutei Hassani, Zoubir Djerada, Hong Liang, Mohamed El Sanharawi, Antoine Labbé, Christophe Baudouin
PURPOSE: To evaluate a possible clinical application of spectral-domain optical coherence tomography (SD-OCT) using en-face module for the imaging of the corneoscleral limbus in normal subjects and dry eye patients. PATIENTS AND METHODS: Seventy-six subjects were included in this study. Seventy eyes of 35 consecutive patients with dry eye disease and 82 eyes of 41 healthy control subjects were investigated. All subjects were examined with the Avanti RTVue® anterior segment OCT...
2017: PloS One
https://www.readbyqxmd.com/read/29135602/ocular-surface-alterations-in-the-context-of-corneal-in-vivo-confocal-microscopic-characteristics-in-patients-with-fibromyalgia
#15
Kadriye Erkan Turan, Sibel Kocabeyoglu, Isin Unal-Cevik, Figen Bezci, Aysen Akinci, Murat Irkec
PURPOSE: To quantify the morphology of corneal basal epithelium and subbasal nerves and to evaluate the ocular surface alterations in patients with fibromyalgia (FM). METHODS: Patients with FM (n = 34) and healthy controls (n = 42) were enrolled. All participants underwent ocular surface tests in the following order: corneal sensitivity, tear film breakup time, lissamine green staining, Schirmer test, and the Ocular Surface Disease Index questionnaire. Basal epithelial cells and subbasal nerves were evaluated using in vivo confocal microscopy (IVCM)...
November 9, 2017: Cornea
https://www.readbyqxmd.com/read/29133179/stage-related-central-corneal-epithelial-transformation-in-congenital-aniridia-associated-keratopathy
#16
Neil Lagali, Bogumil Wowra, Dariusz Dobrowolski, Tor Paaske Utheim, Per Fagerholm, Edward Wylegala
PURPOSE: To relate central corneal epithelial phenotype to degree of keratopathy in a limbal stem cell deficient population. METHODS: 37 patients (67 eyes) with aniridia-associated keratopathy (AAK) underwent corneal examination including slit lamp biomicroscopy to determine the Grade of AAK, Cochet-Bonnet esthesiometry, and in vivo confocal microscopy (IVCM) to assess morphology of the central corneal epithelium and subepithelial region. RESULTS: AAK Grade ranged from 1 (limbal involvement only) to 4 (total conjunctivalisation), with progression from Grade 1 occurring after the age of 20...
November 10, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29129651/dendritic-cells-in-the-cornea-during-herpes-simplex-viral-infection-and-inflammation
#17
REVIEW
Min S Kwon, Nicole A Carnt, Naomi R Truong, Ushasree Pattamatta, Andrew J White, Chameen Samarawickrama, Anthony L Cunningham
Herpes simplex keratitis is commonly caused by Herpes simplex Virus Type 1 (HSV-1), which primarily infects eyelids, corneas or conjunctiva. HSV-1- through sophisticated interactions with dendritic cells (DCs), a type of antigen-presenting cell)-initiates pro-inflammatory responses in the cornea. Corneas were once thought to be an immune privileged region; however, with the recent discovery of DCs that reside in the cornea, this long held conjecture has been overturned. Therefore, evaluating the clinical, preclinical, and cell-based studies that investigate the roles of DCs in corneas infected with HSV is critical...
November 9, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29101151/laser-scanning-in-vivo-confocal-microscopy-ivcm-for-evaluating-human-corneal-sub-basal-nerve-plexus-parameters-protocol-for-a-systematic-review
#18
Manikkuwadura Eranda Harshan De Silva, Alexis Ceecee Zhang, Amalia Karahalios, Holly Rose Chinnery, Laura Elizabeth Downie
INTRODUCTION: Laser scanning in vivo confocal microscopy (IVCM) enables non-invasive, high-resolution imaging of the cornea. In recent years, there has been a vast increase in researchers using laser scanning IVCM to image and quantify corneal nerve parameters. However, a range of methodological approaches have been adopted. The primary aim of this systematic review is to critically appraise the reported method(s) of primary research studies that have used laser scanning IVCM to quantify corneal sub-basal nerve plexus (SBNP) parameters in humans, and to examine corneal nerve parameters in healthy individuals...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29099641/intraocular-lymphoma-masquerading-as-recurrent-iridocyclitis-findings-based-on-in-vivo-confocal-microscopy
#19
Pu Zhang, Jiao Tian, Ling Gao
PURPOSE: To emphasize the application prospects of in vivo confocal microscopy (IVCM) in distinguishing intraocular lesions from inflammatory and neoplastic diseases. METHODS: Retrospective case report. RESULTS: A patient with neoplastic masquerade syndrome initially underwent IVCM examination. After six separate intravitreal injections of 400 mg/0.1 ml methotrexate, IVCM revealed a complete remission of intraocular lymphoma. CONCLUSIONS: Although IVCM findings alone are not enough to diagnose intraocular neoplasm with absolute certainty, they can provide useful indication for distinguishing between intraocular inflammatory diseases and neoplasms...
November 3, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29077583/phenotypic-characterization-of-corneal-endothelial-dystrophy-in-german-shorthaired-and-wirehaired-pointers-using-in-vivo-advanced-corneal-imaging-and-histopathology
#20
Olivia R Shull, Christopher M Reilly, Lola B Davis, Christopher J Murphy, Sara M Thomasy
PURPOSE: To evaluate corneal morphology using ultrasonic pachymetry (USP), Fourier-domain optical coherence tomography (FD-OCT), and in vivo confocal microscopy (IVCM) in 2 related canine breeds-German shorthaired pointers (GSHPs) and German wirehaired pointers (GWHPs)-with and without corneal endothelial dystrophy (CED). This condition is characterized by premature endothelial cell degeneration leading to concomitant corneal edema and is similar to Fuchs endothelial corneal dystrophy...
October 25, 2017: Cornea
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