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https://www.readbyqxmd.com/read/29032001/efficacy-of-self-retained-cryopreserved-amniotic-membrane-for-treatment-of-neuropathic-corneal-pain
#1
Melina I Morkin, Pedram Hamrah
PURPOSE: Treatment of neuropathic corneal pain (NCP) remains intricate, and involves a long-term combined multistep approach. The self-retained cryopreserved amniotic membrane (PROKERA(®), Bio-Tissue, Miami,FL) has been utilized for multiple ocular surface disorders. We evaluate the efficacy, safety, and tolerability of ProKera(®) Slim [PKS] and ProKera(®) Clear [PKC] in the treatment of NCP. METHODS: Retrospective case series of 9 patients who received PKS/PKC for the acute treatment of NCP...
October 12, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28990996/subbasal-nerve-plexus-changes-in-chronic-migraine
#2
Rohit Shetty, Rashmi Deshmukh, Rushad Shroff, Charmy Dedhiya, Chaitra Jayadev
PURPOSE: Migraine is a multifactorial disorder that presents with unilateral headache and several sensory symptoms. Photophobia is one of the ophthalmic manifestations that cause significant morbidity. The trigeminal pathway that innervates the cornea in the form of afferents has been implicated in photophobia associated with chronic migraine. This study investigates changes in the corneal subbasal nerve plexus (SBNP) in chronic migraine patients with and without photophobia. METHODS: Thirty-six patients with migraine and photophobia (group 1), 24 patients with migraine without photophobia (group 2), and 24 age- and sex-matched controls (group 3) were studied...
October 5, 2017: Cornea
https://www.readbyqxmd.com/read/28963702/in-vivo-confocal-laser-microscopy-of-morphologic-changes-after-small-incision-lenticule-extraction-with-accelerated-cross-linking-smile-xtra-in-patients-with-thin-corneas-and-high-myopia
#3
Yugui Zhou, Manli Liu, Ting Zhang, Hua Zheng, Yuan Sun, Xiaonan Yang, Shengbei Weng, Haiqin Lin, Quan Liu
PURPOSE: To evaluate the microstructural modifications and safety of small incision lenticule extraction combined with accelerated cross-linking (SMILE Xtra) in high myopia and thin corneas by means of in vivo confocal microscopy (IVCM) and 3D-OCT after a 6-month follow-up. METHODS: Forty-three eyes with high myopia and thin corneas were enrolled. All eyes underwent SMILE procedure. After the lenticule was extracted, 0.25% riboflavin was injected into the interface and allowed to diffuse for 60 s...
September 29, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28923503/in-vivo-confocal-microscopy-detects-bilateral-changes-of-corneal-immune-cells-and-nerves-in-unilateral-herpes-zoster-ophthalmicus
#4
Bernardo M Cavalcanti, Andrea Cruzat, Afsun Sahin, Deborah Pavan-Langston, Eric Samayoa, Pedram Hamrah
PURPOSE: To analyze bilateral corneal immune cell and nerve alterations in patients with unilateral herpes zoster ophthalmicus (HZO) by laser in vivo confocal microscopy (IVCM) and their correlation with corneal sensation and clinical findings. MATERIALS AND METHODS: This is a prospective, cross-sectional, controlled single-center study. Twenty-four eyes of 24 HZO patients and their contralateral clinically unaffected eyes and normal controls (n = 24) were included...
September 15, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28917411/accelerated-15%C3%A2-mw-pulsed-light-crosslinking-to-treat-progressive-keratoconus-two-year-clinical-results
#5
Cosimo Mazzotta, Stefano Baiocchi, Simone Alex Bagaglia, Mario Fruschelli, Alessandro Meduri, Miguel Rechichi
PURPOSE: To assess the clinical and microstructural results of accelerated 15 mW pulsed-light corneal crosslinking (CXL) to treat progressive keratoconus. SETTING: Siena Crosslinking Center, Siena, Italy. DESIGN: Prospective case series. METHODS: After epithelium removal (with Epi-Clear) and 10 minutes stromal soaking with riboflavin 0.1% hydroxypropyl methylcellulose solution, all eyes had 15 mW/cm(2) pulsed-light epithelium-off accelerated CXL for 6 minutes of ultraviolet-A (UVA) irradiation (1 second on/1 second off), maintaining a total UVA exposure of 12 minutes at a fluence of 5...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28894606/corneal-nerve-regeneration-after-self-retained-cryopreserved-amniotic-membrane-in-dry-eye-disease
#6
Thomas John, Sean Tighe, Hosam Sheha, Pedram Hamrah, Zeina M Salem, Anny M S Cheng, Ming X Wang, Nathan D Rock
PURPOSE: To evaluate the efficacy of self-retained cryopreserved amniotic membrane (CAM) in promoting corneal nerve regeneration and improving corneal sensitivity in dry eye disease (DED). METHODS: In this prospective randomized clinical trial, subjects with DED were randomized to receive CAM (study group) or conventional maximum treatment (control). Changes in signs and symptoms, corneal sensitivity, topography, and in vivo confocal microscopy (IVCM) were evaluated at baseline, 1 month, and 3 months...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28878217/in-vivo-confocal-microscopy-evaluation-of-ocular-surface-with-graft-versus-host-disease-related-dry-eye-disease
#7
Jingliang He, Yoko Ogawa, Shin Mukai, Yumiko Saijo-Ban, Mizuka Kamoi, Miki Uchino, Mio Yamane, Nobuhiro Ozawa, Masaki Fukui, Takehiko Mori, Shinichiro Okamoto, Kazuo Tsubota
Dry eye disease (DED) is often elicited by graft-versus-host disease (GVHD), an extensive complication of hematopoietic stem cell transplantation (HSCT). To unravel the mechanism of this type of DED, in vivo confocal microscopy (IVCM) was used to investigate alterations in the state of the sub-basal nerves, dendritic cells (DCs) and globular immune cells (GICs) in the central cornea and limbal epithelia. In this study, we examined 12 HSCT recipients with GVHD-caused DED and 10 HSCT recipients without GVHD-associated DED and evaluated the clinical parameters in the 2 groups...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875340/corneal-features-in-ocular-graft-versus-host-disease-by-in-vivo-confocal-microscopy
#8
Tudor C Tepelus, Gloria B Chiu, Jyotsna Maram, Jianyan Huang, Vikas Chopra, SriniVas R Sadda, Olivia L Lee
PURPOSE: The purpose of our study was to determine the morphological features of the corneal epithelial layers, sub-basal nerve plexus and anterior stroma in patients with ocular graft-versus-host disease (oGVHD) compared to non-GVHD dry eyes and normal controls, using in vivo confocal microscopy (IVCM). METHODS: IVCM was used to capture central cornea images from eight volunteers with normal healthy eyes, ten patients with non-GVHD dry eye syndrome (DES) and 15 patients with clinically diagnosed oGVHD, in a cross-sectional study...
September 5, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28852187/in-vivo-confocal-microscopy-of-posner-schlossman-syndrome-comparison-with-herpes-simplex-keratitis-hla-b27-anterior-uveitis-and-acute-attack-of-primary-angle-closure
#9
Ying Hong, Miao Wang, Lingling Wu
To investigate in vivo confocal microscopy (IVCM) findings in patients with Posner-Schlossman Syndrome (PSS), we compared the IVCM findings from the eyes of patients with: PSS (44 eyes); herpes simplex keratitis (HSK) (45 eyes); HLA-B27 anterior uveitis (B27AU) (45 eyes); and with acute attack of primary angle closure (aPAC) (43 eyes). The central Langerhans cells (LCs) grade at the level of corneal basal epithelial cells of the PSS group (2.33 ± 0.55) was similar to that of the HSK group (2.63 ± 0...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28768500/long-term-safety-and-tolerability-of-tafluprost-0-0015-vs-timolol-0-1-preservative-free-in-ocular-hypertensive-and-in-primary-open-angle-glaucoma-patients-a-cross-sectional-study
#10
Teresa Rolle, Roberta Spinetta, Raffaele Nuzzi
BACKGROUND: The effects of preservatives of antiglaucoma medications on corneal surface and tear function have been widely shown in literature; it's not the same as regards the active compounds themselves. The purpose of our study was to compare Ocular Surface Disease (OSD) signs and symptoms of Tafluprost 0.0015% versus preservative free (PF) Timolol 0.1% eyedrops in ocular hypertensive (OH) and in primary open-angle glaucoma (POAG) patients. METHODS: A cross-sectional study included patients in monotherapy for at least 36 months with Tafluprost 0...
August 3, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28751986/evaluation-of-bleb-morphology-and-reduction-in-iop-and-glaucoma-medication-following-implantation-of-a-novel-gel-stent
#11
Antonio Maria Fea, Roberta Spinetta, Paola Maria Loredana Cannizzo, Giulia Consolandi, Carlo Lavia, Vittoria Aragno, Francesco Germinetti, Teresa Rolle
OBJECTIVE: To evaluate the efficacy and safety of the Xen Gel Stent and provide a macro- and microscopic analyses of bleb morphology. METHODS: A prospective 12-month study on patients with primary open-angle glaucoma. Patients underwent implantation of the XEN Gel Stent (Allergan INC, Dublin, Ireland) either alone or combined with a cataract surgery. Biomicroscopy, in vivo confocal microscopy (IVCM), and anterior segment-optical coherence tomography (AS-OCT) were used to assess bleb morphology...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28676989/in-vivo-and-ex-vivo-evaluation-of-cell-cell-interactions-adhesion-and-migration-in-ocular-surface-of-patients-undergone-excimer-laser-refractive-surgery-after-topical-therapy-with-different-lubricant-eyedrops
#12
Roberta Calienno, Claudia Curcio, Manuela Lanzini, Mario Nubile, Leonardo Mastropasqua
PURPOSE: To investigate, in vivo by means of in vivo confocal microscopy (IVCM) and ex vivo by impression cytology, epithelial cellular damage after excimer laser refractive surgery in patients under different topical lubricant therapies. METHODS: Two hundred eyes of 100 patients, undergone bilateral excimer laser refractive surgery for medium myopic error correction [spherical equivalent refraction from -1.75 to -3.50 dioptres (D) with refractive astigmatism under -0...
July 4, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28654937/handheld-in-vivo-reflectance-confocal-microscopy-for-the-diagnosis-of-eyelid-margin-and-conjunctival-tumors
#13
Elisa Cinotti, Aurélie Singer, Bruno Labeille, Damien Grivet, Pietro Rubegni, Catherine Douchet, Frédéric Cambazard, Gilles Thuret, Philippe Gain, Jean Luc Perrot
Importance: The clinical diagnosis of conjunctival and eyelid margin tumors is challenging, and new noninvasive imaging techniques could be valuable in this field. Objective: To assess the diagnostic accuracy of handheld in vivo reflectance confocal microscopy (IVCM) for the diagnosis of eyelid margin and conjunctival tumors. Design: A prospective observational study was conducted at University Hospital of Saint-Etienne from January 2, 2011, to December 31, 2016 (inclusion of patients until December 31, 2015, and follow-up until December 31, 2016)...
August 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28648908/intraventricular-cavernomas-of-the-third-ventricle-report-of-2-cases-and-a-systematic-review-of-the-literature
#14
REVIEW
Vivek B Beechar, Visish M Srinivasan, Oleg E Reznik, Anish Sen, Tiemo J Klisch, Alexander E Ropper, Jacob J Mandel, Kent A Heck, Timothy J Seipel, Akash J Patel
BACKGROUND: Intraventricular cavernous malformations are relatively rare benign vascular malformations. Patients may be asymptomatic or present with headache, seizure, hemorrhage, or neurologic deficits. We report 2 cases of patients with cavernomas in the third ventricle and at the foramen of Monro. We also performed a systematic review of the literature to examine the clinical features and efficacy of the current standard of care for these lesions. METHODS: We performed the systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
September 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28586797/in-vivo-confocal-imaging-of-the-conjunctiva-as-a-predictive-tool-for-the-glaucoma-filtration-surgery-outcome
#15
Rodolfo Mastropasqua, Vincenzo Fasanella, Lorenza Brescia, Francesco Oddone, Cesare Mariotti, Silvio Di Staso, Luca Agnifili
Purpose: To examine the preoperative conjunctival dendritic cell density (DCD), goblet cell density (GCD), and stromal meshwork reflectivity (SMR) in glaucomatous patients undergoing filtration surgery, using in vivo confocal microscopy (IVCM). Methods: Sixty-six patients were enrolled. At baseline, IVCM was performed at the site planned for surgery, and was repeated after 12 months at bleb site. Surgery was successful when a one-third reduction of baseline IOP was obtained at the last follow-up...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28542085/quantitative-analysis-of-depth-distribution-and-density-of-cysts-in-acanthamoeba-keratitis-using-confocal-microscopy
#16
Ping Huang, Tudor Tepelus, Laura A Vickers, Elmira Baghdasaryan, Jianyan Huang, John A Irvine, Hugo Y Hsu, Srinivas Sadda, Olivia L Lee
PURPOSE: To quantify the density, distribution, and depth of invasion of cysts in the corneas of eyes with acanthamoeba keratitis (AK) by in vivo confocal microscopy (IVCM) with a novel scanning pattern. METHODS: The medical records of patients with AK evaluated at the Doheny Eye Center UCLA between September 2014 and July 2016 were reviewed retrospectively. Patients with clinically diagnosed AK underwent IVCM at various time points during their clinical course...
May 23, 2017: Cornea
https://www.readbyqxmd.com/read/28532937/collagen-crosslinking-with-conventional-and-accelerated-ultraviolet-a-irradiation-using-riboflavin-with-hydroxypropyl-methylcellulose
#17
Anne Marie Hagem, Andreas Thorsrud, Gunhild Falleth Sandvik, Marianne Råen, Liv Drolsum
PURPOSE: To evaluate corneal collagen crosslinking (CXL) with conventional and accelerated ultraviolet-A (UVA) irradiation using riboflavin with methylcellulose. SETTING: Department of Ophthalmology, Oslo University Hospital, Oslo, Norway. DESIGN: Prospective randomized case series. METHODS: Patients with keratoconus were randomized to have CXL using conventional 3 mW/cm(2) UVA irradiation for 30 minutes (CXL30) or accelerated 9 mW/cm(2) UVA irradiation for 10 minutes (CXL10)...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28528377/correlation-between-corneal-innervation-and-inflammation-evaluated-with-confocal-microscopy-and-symptomatology-in-patients-with-dry-eye-syndromes-a-preliminary-study
#18
Tudor C Tepelus, Gloria B Chiu, Jianyan Huang, Ping Huang, SriniVas R Sadda, John Irvine, Olivia L Lee
PURPOSE: To evaluate corneal innervation and inflammatory cell infiltration using in vivo confocal microscopy (IVCM) and to correlate these findings with subjective symptoms of dry eye, as measured by the Ocular Surface Disease Index (OSDI) in patients with non-Sjögren's (NSDE) and Sjögren's syndrome dry eyes (SSDE). METHODS: Central corneal images were prospectively captured from 10 age-matched healthy control eyes, 24 eyes with clinically diagnosed NSDE and 44 eyes with clinically diagnosed SSDE, using IVCM (HRT III RCM)...
May 20, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28526271/an-in-vitro-urinary-catheterization-model-that-approximates-clinical-conditions-for-evaluation-of-innovations-to-prevent-catheter-associated-urinary-tract-infections
#19
R Y R Chua, K Lim, S S J Leong, P A Tambyah, B Ho
BACKGROUND: Catheter-associated urinary tract infections (CAUTI) account for approximately 25% of nosocomial infections globally, and often result in increased morbidity and healthcare costs. An additional concern is the presence of microbial biofilms which are major reservoirs of bacteria, especially antibiotic-resistant bacteria, in catheters. Since introduction of the use of closed drainage systems, innovations to combat CAUTI have not led to significant improvements in clinical outcomes...
May 17, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28480834/the-conjunctiva-associated-lymphoid-tissue-in-chronic-ocular-surface-diseases
#20
Rodolfo Mastropasqua, Luca Agnifili, Vincenzo Fasanella, Mario Nubile, Agbeanda A Gnama, Gennaro Falconio, Paolo Perri, Silvio Di Staso, Cesare Mariotti
Ocular surface diseases (OSDs) represent a widely investigated field of research given their growing incidence and the negative impact on quality of life. During OSDs, cytokines generated by damaged epithelia trigger and deregulate the lymphoid cells composing the eye-associated lymphoid tissues, inducing an immune-mediated chronic inflammation that amplifies and propagates the disease during time. The conjunctiva-associated lymphoid tissue (CALT), given its particular position that permits immune cells covering the cornea, might play a crucial role in the development of OSDs...
May 8, 2017: Microscopy and Microanalysis
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