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https://www.readbyqxmd.com/read/28345395/evaluation-of-the-predictive-value-of-cha2ds2-vasc-score-for-in-stent-restenosis
#1
Samet Yilmaz, Mehmet Kadri Akboga, Dursun Aras, Serkan Topaloglu
The CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, previous stroke, vascular disease, age 65-74 years, female gender) score is used to estimate thromboembolic risk in atrial fibrillation (AF). Its usefulness in predicting in-stent restenosis (ISR) is unknown. We evaluated the predictive value of the CHA2DS2-VASc score in AF-free patients who have undergone stent implantation. A total of 1350 patients who underwent coronary angiography and successful bare-metal stent implantation were analyzed...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28345224/involvement-of-multiple-chlamydia-suis-genotypes-in-porcine-conjunctivitis
#2
R Chahota, H Ogawa, K Ohya, T Yamaguchi, K D E Everett, H Fukushi
Chlamydia suis has been detected in numerous disease conditions of pigs, particularly in eye infections. This study examined recurring conjunctivitis cases in five commercial pig farms in Japan. 40.5% of the cases were identified as Chlamydia positive using impression cytology of ocular smears and a genus-specific direct fluorescent antibody. C. suis was detected in 59.5% of the samples using PCR tests targeting 16S-23S rRNA intergenic spacer region (ISR) and ompA gene. Genetic analysis of PCR amplicons revealed nine sequence variants of 16S-23S rRNA ISR and 20 sequence variants within ompA gene...
March 27, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28344639/aflatoxin-b1-inhibits-the-type-1-interferon-response-pathway-via-stat1-suggesting-another-mechanism-of-hepatocellular-carcinoma
#3
Patrick W Narkwa, David J Blackbourn, Mohamed Mutocheluh
BACKGROUND: Aflatoxin B1 (AFB1) contamination of food is very high in most sub-Saharan African countries. AFB1 is known to cause hepatocellular carcinoma (HCC) by inducing mutation in the tumour suppressor gene TP53. The number of new HCC cases is high in West Africa with an accompanying high mortality. The type I interferon (IFN) pathway of the innate immune system limits viral infections and exerts its anti-cancer property by up-regulating tumour suppressor activities and pro-apoptotic pathways...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28338163/-risk-factors-of-postoperative-urinary-retention-after-rectal-cancer-surgery
#4
Yong Zhao, Xiaoling Hou, Yujuan Zhao, Yingying Feng, Bin Zhang, Ke Zhao
OBJECTIVE: To investigate the risk factors of postoperative urinary retention after rectal cancer surgery. METHODS: Clinical data of 133 patients with rectal cancer undergoing radical surgery from January 2013 to September 2014 in the General Hospital of the PLA Rocket Force were retrospectively analyzed. Time to the first removal of urinary catheter, incidence of postoperative urinary retention, and time to re-insert indwelling catheter were recorded. Risk factors of urinary retention were analyzed...
March 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28337233/diagnostic-value-of-optimised-real-time-sonoelastography-in-the-assessment-of-liver-fibrosis-in-chronic-hepatitis-b-and-c
#5
Katarzyna Kalita, Krzysztof Filipczak, Małgorzata Bieńkiewicz, Wojciech Deroń, Zbigniew Deroń, Anna Piekarska, Anna Płachcińska, Jacek Kuśmierek
AIM: To optimise the method of real-time elastography (RTE) in the assessment of liver fibrosis using an in-house prepared method for elastogram analysis, as well as a semiquantitative analysis based on newly introduced parameters. MATERIAL AND METHODS: Sonoelastography was performed in 94 patients with various degrees of liver fibrosis and also in 25 healthy volunteers. As a reference method for diagnostic efficacy of sonoelastography-based parameters used for the assessment of fibrosis degree in patients with chronic B and C hepatitis, a liver biopsy was used...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28334335/antagonism-between-two-root-associated-beneficial-pseudomonas-strains-does-not-affect-plant-growth-promotion-and-induced-resistance-against-a-leaf-chewing-herbivore
#6
Nurmi Pangesti, Simon Vandenbrande, Ana Pineda, Marcel Dicke, Jos M Raaijmakers, Joop J A Van Loon
Plant growth-promoting microbes residing on the roots may cooperate or compete, thereby affecting their collective benefit to the host plant. Pseudomonas simiae WCS417r (formerly known as P. fluorescens WCS417r) and Pseudomonas fluorescens SS101 are well known for their ability to induce systemic resistance (ISR) in Arabidopsis. Here, we evaluate how these species interact on the roots of Arabidopsis thaliana Col-0 and how their co-inoculation affects plant defense to the leaf-chewing herbivore Mamestra brassicae and plant growth promotion...
March 15, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28327944/a-phase-2-randomized-double-blind-placebo-%C3%A2-controlled-study-of-chemo-immunotherapy-combination-using-motolimod-with-pegylated-liposomal-doxorubicin-in-recurrent-or-persistent-ovarian-cancer-a-gynecologic-oncology-group-partners-study
#7
B J Monk, M F Brady, C Aghajanian, H A Lankes, T Rizack, J Leach, J M Fowler, R Higgins, P Hanjani, M Morgan, R Edwards, W Bradley, T Kolevska, P Foukas, E Swisher, K S Anderson, R Gottardo, J K Bryan, M Newkirk, K L Manjarrez, R S Mannel, R M Hershberg, G Coukos
Background: A phase 2, randomized, placebo-controlled trial was conducted in women with recurrent epithelial ovarian carcinoma to evaluate the efficacy and safety of motolimod-a Toll-like receptor 8 (TLR8) agonist that stimulates robust innate immune responses-combined with pegylated liposomal doxorubicin (PLD), a chemotherapeutic that induces immunogenic cell death. Patients and methods: Women with ovarian, fallopian tube, or primary peritoneal carcinoma were randomized 1 : 1 to receive PLD in combination with blinded motolimod or placebo...
February 21, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28324231/occurrence-and-virulence-properties-of-vibrio-and-salinivibrio-isolates-from-tropical-lagoons-of-the-southern-caribbean-sea
#8
Milagro Fernández-Delgado, Paula Suárez, Sandra Giner, Virginia Sanz, Jessy Peña, Damarys Sánchez, M Alexandra García-Amado
The Vibrionaceae are Gram-negative bacteria present in marine and estuarine environments worldwide, including several species known as important pathogens to humans and aquatic organisms. The aim of this research was to investigate the occurrence and virulence properties of Vibrio and Salinivibrio isolated from lagoons at Cuare Wildlife Refuge and Margarita Island in the southern Caribbean Sea. Water, plankton and oyster samples were collected during October 2011 and March 2012 and examined by specific PCR and culture methods...
March 21, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28320686/characteristics-of-early-versus-late-in-stent-restenosis-in-second-generation-drug-eluting-stents-an-optical-coherence-tomography-study
#9
Lei Song, Gary S Mintz, Dong Yin, Myong Hwa Yamamoto, Chee Yang Chin, Mitsuaki Matsumura, Ajay J Kirtane, Manish A Parikh, Jeffrey W Moses, Ziad A Ali, Richard A Shlofmitz, Akiko Maehara
AIMS: In-stent restenosis (ISR) is an important cause of DES failure and target vessel revascularization. We evaluated differences between early and late-presenting restenosis in second-generation drug-eluting stents (DES) using optical coherence tomography (OCT). METHODS AND RESULTS: Overall, 171 cases of second-generation DES ISR with a follow-up OCT minimum lumen area <3.0mm2 were included; 33.3% of patients (n=57) had early ISR; and 67.7% (n=114) had late ISR (duration from stent implantation >1 year)...
March 21, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28300418/incurred-sample-reanalysis-of-fingolimod-and-fingolimod-phosphate-in-blood-stability-evaluation-and-application-to-a-rat-pharmacokinetic-study
#10
Ramakrishna Nirogi, Nagasurya Prakash Padala, Devender Reddy Ajjala, Rajesh Kumar Boggavarapu, Praveen Kunduru
BACKGROUND: Incurred sample reanalysis (ISR) is an in-study validation parameter, which reinforces that the validated bioanalytical methods are reproducible. ISR of whole blood samples is complex when the test compounds can interconvert, ex vivo. Fingolimod and fingolimod phosphate are highly distributed in the blood cellular components and undergo rapid interconversion, both in vivo and ex vivo. An LC-MS/MS method capable of simultaneous quantification of fingolimod and fingolimod phosphate with the controlled sample preparation procedure is essential...
March 16, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28295660/in-stent-neoatherosclerosis-and-tissue-characteristics-of-restenotic-lesions-following-implantation-of-second-generation-drug-eluting-stents-in-unrestricted-coronary-lesions-optical-frequency-domain-imaging-study
#11
Mahmoud Sabbah, Kazushige Kadota, Azza El-Eraky, Hanan M Kamal, Ahmed-Tageldien Abdellah, Ahmed El Hawary
BACKGROUND: Differences in stent platform, polymer coatings, and antirestenotic drugs among the current in use second-generation drug-eluting stents (G2-DESs) may induce significant variations in neointimal response and vascular healing, which may impact the prevalence of neoatherosclerosis (NA) and morphological appearance of the restenotic tissue. METHODS AND RESULTS: Utilizing Optical frequency domain imaging, two independent reviewers, retrospectively compared the prevalence of neoatherosclerosis (NA), and the morphological differences, and tissue characteristics of 50 G2-DESs in-stent restenosis (ISR) lesions (35 everolimus-eluting stent [22 cobalt-chromium (CoCr), 13 platinum-chromium (PtCr)], and 15 biolimus-eluting stent [BES]) implanted liberally in unrestricted coronary lesions...
March 10, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28293243/induced-systemic-resistance-against-botrytis-cinerea-by-bacillus-cereus-ar156-through-a-ja-et-and-npr1-dependent-signaling-pathway-and-activates-pamp-triggered-immunity-in-arabidopsis
#12
Pingping Nie, Xia Li, Shune Wang, Jianhua Guo, Hongwei Zhao, Dongdong Niu
Induced resistance response is a potent and cost effective plant defense against pathogen attack. The effectiveness and underlying mechanisms of the suppressive ability by Bacillus cereus AR156 to Pseudomonas syringae pv. tomato DC3000 (Pst DC3000) in Arabidopsis has been investigated previously; however, the strength of induced systemic resistance (ISR) activity against Botrytis cinerea remains unknown. Here, we show that root-drench application of AR156 significantly reduces disease incidence through activation of ISR...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28291857/effect-of-maxillary-sinus-membrane-perforation-on-implant-survival-rate-a-retrospective-study
#13
Carlos Eduardo de Almeida Ferreira, Carolina Borges Martinelli, Arthur Belém Novaes, Túlio Bonna Pignaton, Camila Coser Guignone, Adriana Luísa Gonçalves de Almeida, Eduardo Saba-Chujfi
PURPOSE: The aim of this retrospective study was to evaluate implant survival rates (ISRs) for implants placed in grafted sinuses where a membrane perforation occurred during augmentation using exclusively anorganic bovine bone (ABB) by means of clinical and radiographic examinations. Histologic information of five biopsy specimens taken from large membrane perforations is also presented. MATERIALS AND METHODS: Consecutive patients who underwent sinus augmentation procedures at a private practice Dental Institute between 2004 and 2013 were collected from a computer database...
March 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28291849/vertical-ridge-augmentation-in-the-atrophic-mandible-a-systematic-review-and-meta-analysis
#14
Basel Elnayef, Alberto Monje, Jordi Gargallo-Albiol, Pablo Galindo-Moreno, Hom-Lay Wang, Federico Hernández-Alfaro
PURPOSE: To systematically appraise the effectiveness/reliability of vertical ridge augmentation (VRA) in the atrophic mandible. Articles that addressed any one of the following four areas were included in this study: amount of VRA, implant survival (ISR) and success rates (SSR) in the area of newly regenerated bone, complication rate during the bone augmentation procedure, and bone resorption. MATERIALS AND METHODS: An electronic literature search was conducted by two independent reviewers in several databases, including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register databases for articles reporting VRA in the atrophic mandible via distraction osteogenesis (DO), inlay block grafting (IBG), onlay block grafting (OBG), and guided bone regeneration (GBR)...
March 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28289834/the-impact-of-anastomotic-leakage-on-anal-function-following-intersphincteric-resection
#15
Mitsuru Yokota, Masaaki Ito, Yuji Nishizawa, Akihiro Kobayashi, Norio Saito
BACKGROUND: Data regarding anastomotic leakage (AL) following intersphincteric resection (ISR) are lacking. We aimed to evaluate the effect of AL on anal function in a retrospective review of patients who developed AL following ISR. METHODS: We evaluated 341 consecutive patients who underwent ISR between 2000 and 2012. Patients were classified into three groups: anastomotic dehiscence (AD), major AL (Clavien-Dindo grade III+), or control (<grade III or no AL)...
March 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28286904/short-and-long-term-mortality-due-to-sepsis-in-patients-with-rheumatoid-arthritis
#16
Orit Barrett, Ella Abramovich, Jacob Dreiher, Victor Novack, Mahmoud Abu-Shakra
Severe infections and sepsis are common among patients with rheumatoid arthritis (RA) and are associated with increased morbidity and mortality risks. To determine whether RA is an independent risk factor for short- and long-term mortality in patients admitted to an Intensive Care Unit (ICU) with sepsis. A retrospective age- and sex-matched cohort study, based on data of the SEPSIS-ISR Registry, an ongoing study that collects data on all patients admitted with the diagnosis of sepsis to the ICUs of 7 large hospitals during the period 2002-2012...
March 12, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28281026/neoatherosclerosis-assessed-with-optical-coherence-tomography-in-restenotic-bare-metal-and-first-and-second-generation-drug-eluting-stents
#17
Lei Song, Gary S Mintz, Dong Yin, Myong Hwa Yamamoto, Chee Yang Chin, Mitsuaki Matsumura, Khady Fall, Ajay J Kirtane, Manish A Parikh, Jeffrey W Moses, Ziad A Ali, Richard A Shlofmitz, Akiko Maehara
Although reported in bare metal stents (BMS) and first-generation drug-eluting stents (DES), little is known about neoatherosclerosis in second-generation DES. We used optical coherence tomography to evaluate neoatherosclerosis among different stent generations. Overall, 274 in-stent restenosis (ISR) lesions (duration from implantation 56.9 ± 47.2 months) in 274 patients were assessed for the presence of neoatherosclerosis. Neoatherosclerosis was identified in 38.7% of lesions (106/274): 23.0% second-generation DES (38/165), 65...
March 9, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28268704/a-bifrequent-passive-sensor-system-for-measurement-of-the-pulse-wave-velocity-in-a-stent
#18
Jonathan Schachtele
In-stent restenosis (ISR) is a frequent complication after stent implantation. Recently, a passive sensor system for integration into a stent has been presented, which is designed to detect an ISR early by measuring the local pulse wave velocity (PWV). This system is based on two pressure sensitive transponders, the resonance frequency of which hits the frequency of a magnetic field generated by an externally applied transceiver coil during a pulse cycle. This method is limited in applicability by the largest PWV it can measure...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267207/listeria-monocytogenes-induces-an-interferon-enhanced-activation-of-the-integrated-stress-response-that-is-detrimental-for-resolution-of-infection-in-mice
#19
Carolina Valderrama, Amy Clark, Fumihiko Urano, Emil R Unanue, Javier A Carrero
Type I interferons (IFNs) induce a detrimental response during Listeria monocytogenes (L. monocytogenes) infection. We were interested in identifying mechanisms linking IFN signaling to negative host responses against L. monocytogenes infection. Herein we found that infection of myeloid cells with L. monocytogenes led to a coordinated induction of type I IFNs and activation of the integrated stress response (ISR). Infected cells did not induce Xbp1 splicing or BiP upregulation, indicating that the unfolded protein response was not triggered...
March 7, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28265266/helz2-is-an-ifn-effector-mediating-suppression-of-dengue-virus
#20
Dahlene N Fusco, Henry Pratt, Stephen Kandilas, Scarlett Se Yun Cheon, Wenyu Lin, D Alex Cronkite, Megha Basavappa, Kate L Jeffrey, Anthony Anselmo, Ruslan Sadreyev, Clarence Yapp, Xu Shi, John F O'Sullivan, Robert E Gerszten, Takuya Tomaru, Satoshi Yoshino, Tetsurou Satoh, Raymond T Chung
Flaviviral infections including dengue virus are an increasing clinical problem worldwide. Dengue infection triggers host production of the type 1 IFN, IFN alpha, one of the strongest and broadest acting antivirals known. However, dengue virus subverts host IFN signaling at early steps of IFN signal transduction. This subversion allows unbridled viral replication which subsequently triggers ongoing production of IFN which, again, is subverted. Identification of downstream IFN antiviral effectors will provide targets which could be activated to restore broad acting antiviral activity, stopping the signal to produce endogenous IFN at toxic levels...
2017: Frontiers in Microbiology
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