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https://www.readbyqxmd.com/read/28208458/double-inverse-stochastic-resonance-with-dynamic-synapses
#1
Muhammet Uzuntarla, Joaquin J Torres, Paul So, Mahmut Ozer, Ernest Barreto
We investigate the behavior of a model neuron that receives a biophysically realistic noisy postsynaptic current based on uncorrelated spiking activity from a large number of afferents. We show that, with static synapses, such noise can give rise to inverse stochastic resonance (ISR) as a function of the presynaptic firing rate. We compare this to the case with dynamic synapses that feature short-term synaptic plasticity and show that the interval of presynaptic firing rate over which ISR exists can be extended or diminished...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28190783/a-retrospective-analysis-of-catheter-based-sources-in-intravascular-brachytherapy
#2
J DeCunha, C Janicki, S A Enger
PURPOSE: Coronary artery disease involves the deposition of plaque along the walls of a coronary artery leading to narrowed or blocked vessels (stenosis) and is one of the main causes of death in developed countries. Percutaneous transluminal coronary angioplasty (PTCA) is used to reverse stenosis. Restenosis (renarrowing) of the treated vessel is a major complication of PTCA. A metal mesh tube (stent) can be placed inside the vessel to prevent restenosis. Tissue stress incurred during PTCA and stenting can provoke neointimal cell proliferation leading to in-stent restenosis (ISR)...
February 10, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28188560/maternal-incarceration-children-s-psychological-adjustment-and-the-mediating-role-of-emotion-regulation
#3
Janice L Zeman, Danielle H Dallaire, Johanna B Folk, Todd M Thrash
Children who live in the context of maternal incarceration (MI) are exposed to both general environmental risk and incarceration-specific risk increasing the probability of their developing externalizing and internalizing behaviors problems. Little research has examined the socio-emotional mechanisms that account for the psychological effects of MI. This research examined children's anger and sadness regulation as mediators between environmental and incarceration-specific risk and psychological functioning...
February 10, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28184335/drug-and-gene-eluting-stents-for-preventing-coronary-restenosis
#4
REVIEW
Kamali Manickavasagam Lekshmi, Hui-Lian Che, Chong-Su Cho, In-Kyu Park
Coronary artery disease (CAD) has been reported to be a major cause of death worldwide. Current treatment methods include atherectomy, coronary angioplasty (as a percutaneous coronary intervention), and coronary artery bypass. Among them, the insertion of stents into the coronary artery is one of the commonly used methods for CAD, although the formation of in-stent restenosis (ISR) is a major drawback, demanding improvement in stent technology. Stents can be improved using the delivery of DNA, siRNA, and miRNA rather than anti-inflammatory/anti-thrombotic drugs...
January 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28183701/association-of-serum-hmgb2-levels-with-in-stent-restenosis-hmgb2-promotes-neointimal-hyperplasia-in-mice-with-femoral-artery-injury-and-proliferation-and-migration-of-vsmcs
#5
Yu Hu He, Xiao Qun Wang, Jian Zhang, Zhu Hui Liu, Wen Qi Pan, Ying Shen, Zheng Bin Zhu, Ling Jie Wang, Xiao Xiang Yan, Ke Yang, Rui Yan Zhang, Wei Feng Shen, Feng Hua Ding, Lin Lu
OBJECTIVE: In a previous study, we established diabetic and nondiabetic minipig models with coronary artery in-stent restenosis (ISR). Mass spectrometry showed that high-mobility group box (HMGB) 2 level was higher in ISR than in non-ISR tissue from diabetic minipigs. We here investigated whether serum HMGB2 levels were related to ISR in CAD patients. The effect of HMGB2 was evaluated in mice with femoral artery wire injury and in human aortic smooth muscle cells. APPROACH AND RESULTS: From 2513 patients undergoing coronary artery intervention and follow-up angiography at ≈1 year, 262 patients were diagnosed with ISR, and 298 patients with no ISR were randomly included as controls...
February 9, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28180940/in-stent-restenosis-after-interventional-treatment-of-carotid-artery-stenoses-a-long-term-follow-up-of-a-single-center-cohort
#6
J Kammler, H Blessberger, T Lambert, J Kellermair, M Grund, A Nahler, M Lichtenauer, S Schwarz, C Reiter, C Steinwender, A Kypta
BACKGROUND: Whereas in-stent restenosis (ISR) is widely discussed after coronary stenting procedures, this phenomenon is a considerable problem after interventional treatment of carotid artery stenosis as well. We sought to quantify ISR rate and to identify important respective risk factors in our cohort. METHODS: We retrospectively analyzed data of our carotid artery stenting database comprising 1165 angiographically successful interventional procedures during the last 19 years...
February 8, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28177775/cellular-stress-associated-with-plasmodium-berghei-ookinete-differentiation
#7
Josefina Duran-Bedolla, Juan Tellez-Sosa, Humberto Valdovinos-Torres, Natalia Pavon, Mabel Buelna-Chontal, Angel Tello-Lopez, Rocio Argotte-Ramos, Mario Henry Rodriguez, Maria Carmen Rodriguez
For malaria transmission, Plasmodium parasites must develop in the mosquito vector. Oxidative stress in the insect midgut, triggered by environmental changes (e.g., pH and temperature), influences the cellular signaling of parasites involved in differentiation from gametocytes to mobil ookinetes. It activates the homeostatic response to stress characterized by the phosphorylation eIF2, the attenuation of protein synthesis and the transcription of genes participating in the unfolded protein response and antioxidant processes, forming a part of an integrated stress response (ISR)...
August 12, 2016: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28177628/manipulating-impulsive-stimulated-raman-spectroscopy-with-a-chirped-probe-pulse
#8
Lorenzo Monacelli, Giovanni Batignani, Giuseppe Fumero, Carino Ferrante, Shaul Mukamel, Tullio Scopigno
Photophysical and photochemical processes are often dominated by molecular vibrations in various electronic states. Dissecting the corresponding -often overlapping- spectroscopic signals from different electronic states is a challenge hampering their interpretation. Here we address impulsive stimulated Raman spectroscopy (ISRS), a powerful technique allowing to coherently stimulate and record Raman active modes using broadband pulses. Using a quantum-mechanical treatment of the ISRS process, we show the mode specific way the diverse components of the broadband probe contribute to the signal generated at a given wavelength...
February 8, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28169215/drug-coated-balloon-angioplasty-for-in-stent-restenosis-of-femoropopliteal-arteries-a-meta-analysis
#9
Salvatore Cassese, Gjin Ndrepepa, Sebastian Kufner, Robert A Byrne, Daniele Giacoppo, Ilka Ott, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Massimiliano Fusaro
AIMS: To perform a meta-analysis investigating the outcomes of patients undergoing percutaneous revascularization with drug-coated balloon (DCB) angioplasty because of femoropopliteal in-stent restenosis (ISR). METHODS AND RESULTS: We searched scientific databases for studies of DCB angioplasty for femoropopliteal ISR. The primary outcome was target lesion revascularization (TLR). The main secondary outcome was recurrent ISR. Other outcomes of interest were Rutherford class (RC) improvement, ankle-brachial index (ABI) and death...
February 7, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28168901/graft-free-maxillary-sinus-floor-elevation-a-systematic-review-and-meta-analysis
#10
Deng-Hui Duan, Jia-Hui Fu, Wei Qi, Yi Du, Jie Pan, Hom-Lay Wang
AIM: This systematic review and meta-analysis aimed to investigate survival rates of dental implants (ISR) placed simultaneously with graft-free maxillary sinus floor elevation. Factors influencing the amount of vertical bone gain (VBG), protruded implant length in sinus at follow-up (PILf), and peri-implant marginal bone loss (MBL) were also evaluated. METHODS: An electronic and manual search for human clinical studies on simultaneous implant placement and graft-free maxillary sinus floor elevation using the lateral window or transcrestal approach, published in the English language from January 1976 to March 2016, was conducted...
February 7, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28165925/molecular-detection-of-candidatus-bartonella-mayotimonensis-in-north-american-bats
#11
Thomas M Lilley, Cali A Wilson, Riley F Bernard, Emma V Willcox, Eero J Vesterinen, Quinn M R Webber, Laura Kurpiers, Jenni M Prokkola, Imran Ejotre, Allen Kurta, Kenneth A Field, DeeAnn M Reeder, Arto T Pulliainen
Candidatus Bartonella mayotimonensis was detected in 2010 from an aortic valve sample of a patient with endocarditis from Iowa, the United States of America. The environmental source of the potentially new endocarditis-causing Bartonella remained elusive. We set out to study the prevalence and diversity of bat-associated Bartonella in North America. During 2015, mist nets and harp traps were used to capture 92 bats belonging to two species: little brown myotis (Myotis lucifugus Le Conte 1831, n = 73) and the gray myotis (M...
February 6, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28155641/deepgene-an-advanced-cancer-type-classifier-based-on-deep-learning-and-somatic-point-mutations
#12
Yuchen Yuan, Yi Shi, Changyang Li, Jinman Kim, Weidong Cai, Zeguang Han, David Dagan Feng
BACKGROUND: With the developments of DNA sequencing technology, large amounts of sequencing data have become available in recent years and provide unprecedented opportunities for advanced association studies between somatic point mutations and cancer types/subtypes, which may contribute to more accurate somatic point mutation based cancer classification (SMCC). However in existing SMCC methods, issues like high data sparsity, small volume of sample size, and the application of simple linear classifiers, are major obstacles in improving the classification performance...
December 23, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28152454/simultaneous-quantification-of-loxapine-loxapine-n-oxide-amoxapine-8-hydroxyloxapine-and-7-hydroxyloxapine-in-human-plasma-using-lc-ms-ms
#13
Min Meng, Nan Zhao, Carrie C Pederson, Edward Harrison, Charisse Green, Steven H Gorman, Scott Reuschel
Loxapine is an antipsychotic medication used for the treatment of schizophrenia. In vivo, loxapine is metabolized to multiple metabolites. A high performance liquid chromatographic-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of loxapine and 4 of its metabolites, loxapine N-oxide, amoxapine (N-desmethyl loxapine), 8-hydroxyloxapine and 7-hydroxyloxapine, in human plasma to support regulated clinical development. During method development, several technical challenges such as poor chromatography, separation of structural isomers, and inadequate sensitivity were met and overcome...
January 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28139220/usefulness-of-drug-eluting-balloons-for-bare-metal-and-drug-eluting-in-stent-restenosis-from-the-ribs-iv-and-v-randomized-trials
#14
Fernando Alfonso, María José Pérez-Vizcayno, Bruno García Del Blanco, Arturo García-Touchard, José-Ramón López-Mínguez, Manel Sabaté, Javier Zueco, Rafael Melgares, Rosana Hernández, Raul Moreno, Antonio Domínguez, Juan Sanchís, Cesar Moris, José Moreu, Angel Cequier, Rafael Romaguera, Fernando Rivero, Javier Cuesta, Nieves Gonzalo, Pilar Jiménez-Quevedo, Alberto Cárdenas, Cristina Fernández
Treatment of patients with drug-eluting stent (DES) in-stent restenosis (ISR) is particularly challenging. We sought to compare results of drug-eluting balloons in patients with DES-ISR with those in patients with bare-metal stent (BMS) ISR. A pooled analysis of the Restenosis Intra-Stent: Drug-Eluting Balloon versus Everolimus-Eluting Stent IV and V randomized trials was performed. Both trials had identical inclusion and exclusion criteria. Results of drug-eluting balloons in 95 patients with BMS-ISR and 154 patients with DES-ISR were compared...
January 5, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28139216/integrated-stress-response-activation-by-sleep-fragmentation-during-late-gestation-in-mice-leads-to-emergence-of-adverse-metabolic-phenotype-in-offspring
#15
Wojciech Trzepizur, Abdelnaby Khalyfa, Zhuanhong Qiao, Brian Popko, David Gozal
BACKGROUND: Late gestational sleep fragmentation (SF) is highly prevalent particularly in obese women, and induces metabolic dysfunction in adult offspring mice. SF induces activation of the integrated stress response (ISR), which might be involved in metabolic disorders. We hypothesized that adult offspring of double mutant mice (DM) involving the critical ISR genes CHOP and GADD34 would be protected from developing obesity and insulin resistance following SF. METHODS: Time-pregnant CHOP/GADD34 DM and wild type (WT) mice were randomly assigned to sleep control (SC) or SF conditions during the last 5days of gestation...
January 21, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28133302/-two-cases-of-locally-recurrent-rectal-cancer-after-intersphincteric-resection-that-were-controlled-with-a-combination-of-chemoradiotherapy-and-abdominoperineal-resection
#16
Yasuhiro Komatsu, Hitoshi Idani, Kazutaka Takahashi, Naoki Mimura, Toshihiro Ogawa, Soichiro Miyake, Michihiro Ishida, Daisuke Satoh, Yasuhiro Choda, Daisuke Sumitani, Masao Harano, Hiroyoshi Matsukawa, Yasutomo Ojima, Shigehiro Shiozaki, Masazumi Okajima
We report 2 cases of locally recurrent rectal cancer after intersphincteric resection(ISR)that were controlled with a combination of chemoradiotherapy and abdominoperineal resection(APR). In Case 1, we performed preoperative chemoradiotherapy( TS-1 plus RT 45 Gy)and APR for the local recurrence of ISR. On pathology, viable neoplastic cells were noted. In Case 2, we performed preoperative chemotherapy(Bmab plus mFOLFOX6)and APR for the local recurrence of ISR. On pathology, no viable neoplastic cells were noted...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133080/-a-case-of-advanced-rectal-cancer-in-which-combined-prostate-removal-and-isr-using-the-da-vinci-surgical-system-with-preoperative-chemotherapy-allowed-curative-resection
#17
Hideaki Kawakita, Kenji Katsumata, Kenta Kasahara, Hiroshi Kuwabara, Masatoshi Shigoka, Takaaki Matsudo, Masanobu Enomoto, Tetsuo Ishizaki, Masayuki Hisada, Kazuhiko Kasuya, Akihiko Tsuchida
A 53-year-old male presented with a chief complaint of dyschezia.Lower gastrointestinal endoscopy confirmed the presence of a type II tumor in the lower part of the rectum, and a biopsy detected a well-differentiated adenocarcinoma.As invasion of the prostate and levator muscle of the anus was suspected on diagnostic imaging, surgery was performed after preoperative chemotherapy.With no clear postoperative complications, the patient was discharged 26 days after surgery. After 24 months, the number of urination ranged from 1 to 6, with a Wexner score of 6 and a mild desire to urinate in the absence of incontinence...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28132981/difference-of-tissue-characteristics-between-early-and-late-restenosis-after-second-generation-drug-eluting-stents-implantation%C3%A3-an-optical-coherence-tomography-study
#18
Hiroyuki Jinnouchi, Shoichi Kuramitsu, Tomohiro Shinozaki, Yusuke Tomoi, Takashi Hiromasa, Yohei Kobayashi, Takenori Domei, Yoshimitsu Soga, Makoto Hyodo, Shinichi Shirai, Kenji Ando
BACKGROUND: The mechanism and time course of in-stent restenosis (ISR) after implantation of second-generation DES have not yet been fully elucidated. We sought to evaluate the differences in tissue characteristics between the different phases of ISR after second-generation DES implantation using optical coherence tomography (OCT).Methods and Results:From June 2010 to December 2015, 324 consecutive patients with 337 ISR lesions underwent OCT. Of these, we analyzed 53 lesions in 53 patients who had their first ISR after second-generation DES implantation and underwent OCT before any procedures...
January 27, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28129392/association-of-the-endothelial-nitric-oxide-synthase-gene-t786c-polymorphism-with-in-stent-restenosis-in-chinese-han-patients-with-coronary-artery-disease-treated-with-drug-eluting-stent
#19
Wen-Ping Zeng, Rui Zhang, Ran Li, Jin-Fang Luo, Xiao-Feng Hu
BACKGROUND AND AIM: Many studies have reported that genetic variants correlate with higher risk for coronary artery disease (CAD) or in-stent restenosis (ISR) after bare metal stent (BMS) implantation. However, there is limited data assessing the impact of these variants on ISR in patients treated with drug-eluting stent (DES). The purpose of this study was to investigate the effects of genetic risk factors on ISR in Chinese Han patients treated with DES. METHODS: A total of 425 patients with a diagnosis of CAD who underwent successful revascularization in native coronary arteries with DES were included in this retrospective study...
2017: PloS One
https://www.readbyqxmd.com/read/28128312/preprocedural-c-reactive-protein-predicts-outcomes-after-primary-percutaneous-coronary-intervention-in-patients-with-st-elevation-myocardial-infarction-a-systematic-meta-analysis
#20
Raluca-Ileana Mincu, Rolf Alexander Jánosi, Dragos Vinereanu, Tienush Rassaf, Matthias Totzeck
Risk assessment in patients with acute coronary syndromes (ACS) is critical in order to provide adequate treatment. We performed a systematic meta-analysis to assess the predictive role of serum C-reactive protein (CRP) in patients with ST-segment elevation myocardial infarction (STEMI), treated with primary percutaneous coronary intervention (PPCI). We included 7 studies, out of 1,033 studies, with a total of 6,993 patients with STEMI undergoing PPCI, which were divided in the high or low CRP group, according to the validated cut-off values provided by the corresponding CRP assay...
January 27, 2017: Scientific Reports
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