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https://www.readbyqxmd.com/read/28534230/trueperella-pyogenes-isolated-from-a-brain-abscess-of-an-adult-roebuck-capreolus-capreolus
#1
Jörn-Peter Wickhorst, Abdulwahed Ahmed Hassan, Omar Hashim Sheet, Tobias Eisenberg, Osama Sammra, Mazen Alssahen, Christoph Lämmler, Ellen Prenger-Berninghoff, Michael Zschöck, Markus Timke, Amir Abdulmawjood
The present study was designed to characterize phenotypically and genotypically a Trueperella pyogenes strain isolated from a brain abscess of an adult roebuck (Capreolus capreolus). The species identity could be confirmed by phenotypical investigations, by MALDI-TOF MS analysis, and by sequencing the 16S ribosomal RNA (rRNA) gene, the 16S-23S rRNA intergenic spacer region (ISR); by sequencing the target genes rpoB, gap, and tuf; and by detection of T. pyogenes chaperonin-encoding gene cpn60 with a previously developed loop-mediated isothermal amplification (LAMP) assay...
May 23, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28526920/effects-of-semaglutide-on-beta-cell-function-and-glycaemic-control-in-participants-with-type-2-diabetes-a-randomised-double-blind-placebo-controlled-trial
#2
Christoph Kapitza, Kirsten Dahl, Jacob B Jacobsen, Mads B Axelsen, Anne Flint
AIMS/HYPOTHESIS: Semaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed. METHODS: In this single-centre, double-blind, placebo-controlled, parallel-group trial, conducted at the Profil Institut für Stoffwechselforschung, Germany, 75 adult (aged 18-64 years) participants with type 2 diabetes (eligibility: HbA1c of 6...
May 19, 2017: Diabetologia
https://www.readbyqxmd.com/read/28514595/flocculation-and-dewatering-of-mature-fine-tailings-using-temperature-responsive-cationic-polymers
#3
Dan Zhang, Thomas Thundat, Ravin Narain
Temperature-responsive copolymer with cationic charge was prepared with N-isopropylacrylamide (NIPAM) and 2-aminoethyl methacrylamide hydrochloride (AEMA) by conventional free-radical polymerization. The flocculation performance of the copolymer, poly(AEMA-st-NIPAM), was compared to five different mixture ratios of polyNIPAM and cationic poly(acrylamide-st-diallyldimethylammonium chloride) (poly(AAm-st-DADMAC)). The effects of polymer mixture ratios, polymer dosages, and temperature on solid-liquid separation as a function of initial settling rates (ISR), supernatant turbidity, sediment solids content and water recovery were investigated...
May 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28502794/mir-125a-5p-modulates-phenotypic-switch-of-vascular-smooth-muscle-cells-by-targeting-ets-1
#4
C Gareri, C Iaconetti, S Sorrentino, C Covello, S De Rosa, C Indolfi
MicroRNAs are key regulators of vascular smooth muscle cells (VSMCs) phenotypic switch, one of the main events responsible for bare metal stent restenosis (ISR) after percutaneous coronary intervention (PCI). miR-125a-5p is an important modulator of differentiation, proliferation and migration in different cell types; however, its role in VSMCs is still unknown. The aim of this study was to evaluate the role of miR-125a-5p in VSMCs phenotypic switch. Our results suggest that miR-125a-5p is highly expressed in VSMCs, but it is down-regulated after vascular injury in vivo...
May 11, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28500614/irf9-stat2-fusion-protein-as-an-innate-immune-inducer-to-activate-mx-and-interferon-stimulated-gene-expression-in-zebrafish-larvae
#5
Chang-Jen Huang, Chih-Ming Chou, Huang-Wei Lien, Cheng-Ying Chu, Jhih-Yun Ho, Yimin Wu, Chia-Hsiung Cheng
Virus infection often causes large amounts of mortality during teleost larvae stage. Strong induction of innate immunity to increase survival rates of teleost larvae has been less reported. In this study, we present a zebrafish IRF9-Stat2 fusion protein (zIRF9-S2C) as a strong innate immunity inducer and characterized induction of interferon-stimulated genes (ISGs) in zebrafish larvae. zIRF9-S2C could mimic IFN-stimulated gene factor 3 (ISGF3) complex to constitutively activate transcription of Mx promoter through IFN-stimulatory element (ISRE) sites...
May 12, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28489985/preclinical-evaluation-of-the-imipridone-family-analogues-of-clinical-stage-anti-cancer-small-molecule-onc201-reveals-potent-anti-cancer-effects-of-onc212
#6
Jessica Wagner, Christina Leah Kline, Marie D Ralff, Avital Lev, Amriti Lulla, Lanlan Zhou, Gary L Olson, Bhaskara Rao Nallaganchu, Cyril H Benes, Joshua E Allen, Varun V Prabhu, Martin Stogniew, Wolfgang Oster, Wafik S El-Deiry
Anti-cancer small molecule ONC201 upregulates the integrated stress response (ISR) and acts as a dual inactivator of Akt/ERK, leading to TRAIL gene activation. ONC201 is under investigation in multiple clinical trials to treat patients with cancer. Given the unique imipridone core chemical structure of ONC201, we synthesized a series of analogues to identify additional compounds with distinct therapeutic properties. Several imipridones with a broad range of in vitro potencies were identified in an exploration of chemical derivatives...
May 10, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28489156/impact-of-free-thyroxine-levels-and-other-clinical-factors-on-bare-metal-stent-restenosis
#7
Uğur Canpolat, Osman Turak, Fırat Özcan, Fatih Öksüz, Mehmet Ali Mendi, Çağrı Yayla, Sinan Aydoğdu
Objective: Thyroid hormones have both direct and indirect effects on thermogenesis such as modulating vascular smooth muscle cell proliferation. However, the influence of more subtle changes in thyroid hormones on coronary atherosclerosis remains a matter of speculation. Smooth muscle cells play a crucial role in the pathogenesis of in-stent restenosis (ISR). However, the relationship between free thyroxine (fT4) and ISR has not been studied. In the present study, we aimed to assess the role of preprocedural serum fT4 level on the development of ISR in patients undergoing coronary bare metal stent (BMS) implantation...
March 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28486842/impact-of-angioscopic-evaluation-for-femoropopliteal-in-stent-restenosis-before-and-after-excimer-laser-atherectomy
#8
Akiko Idemoto, Naotaka Okamoto, Akihiro Tanaka, Naoki Mori, Daisuke Nakamura, Masamichi Yano, Nobuhiko Makino, Yasuyuki Egami, Ryu Shutta, Jun Tanouchi, Masami Nishino
In-stent restenosis (ISR) is a prevalent problem following stenting of femoropopliteal lesions. A potential novel treatment modality for ISR including excimer laser atherectomy (ELA) has become available. We performed ELA for in-stent chronic total occlusion (CTO) of femoropopliteal lesions and evaluated lesion morphology before and after ELA by angioscopy in 2 patients. The angioscopic findings clearly showed removal of in-stent thrombi after ELA. Thus, ELA may be effective for in-stent CTO of femoropopliteal lesions...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28485182/a-quantitative-angiographic-comparison-of-restenotic-tissue-following-placement-of-drug-eluting-stents-and-bare-metal-stents-in-symptomatic-patients-with-femoropopliteal-disease
#9
Gary M Ansel, Michael R Jaff, Jeffrey J Popma, Anthony J Battisti, Aaron E Lottes, Paul Harnish, Michael D Dake
PURPOSE: To evaluate the patterns of in-stent restenosis (ISR) within femoropopliteal bare metal stents (BMS) and drug-eluting stents (DES) as determined by quantitative angiographic analysis. METHODS: Utilizing results from independent core laboratory angiographic imaging analysis, quantitative assessment of the restenotic tissue burden was evaluated in 33 patients with symptomatic femoropopliteal ISR, including 20 lesions in 19 patients (mean age 71.5±8.1 years; 11 men) treated with DES and 14 lesions in 14 patients (mean age 70...
May 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28484288/association-between-vegf-gene-polymorphisms-and-in-stent-restenosis-after-coronary-intervention-treated-with-bare-metal-stent
#10
Zsolt Bagyura, Loretta Kiss, Kristóf Hirschberg, Balázs Berta, Gábor Széplaki, Árpád Lux, Zsolt Szelid, Pál Soós, Béla Merkely
Background. In-stent restenosis (ISR) is the gradual narrowing of the vessel lumen after coronary stent implantation due to the increase in vascular smooth muscle cell proliferation. Vascular endothelial growth factor (VEGF) protein plays an important role in this process. Our aim was to analyze the association of single nucleotide polymorphisms of the VEGF gene (rs2010963 and rs6999447) with the occurrence of ISR after coronary artery bare metal stent (BMS) implantation. Methods. 205 patients with a history of BMS implantation and a repeated coronarography were prospectively enrolled...
2017: Disease Markers
https://www.readbyqxmd.com/read/28476515/independent-predictors-of-in-stent-restenosis-after-drug-eluting-stent-implantation-for-ostial-right-coronary-artery-lesions
#11
Yusuke Watanabe, Kensuke Takagi, Toru Naganuma, Hiroyoshi Kawamoto, Yusuke Fujino, Hisaaki Ishiguro, Satoko Tahara, Naoyuki Kurita, Koji Hosawa, Shotaro Nakamura, Sunao Nakamura
OBJECTIVES: We evaluated the angiographic patterns and predictors of in-stent restenosis (ISR) for ostial lesions of the right coronary artery (RCA) to clarify the mechanism of insoluble restenosis. BACKGROUND: Although ISR of the RCA still occurs, limited data is available regarding the associated angiographic findings. METHODS: Between January 2005 and September 2013, we recruited consecutive patients undergoing routine angiography 6-18months after implantation of a drug-eluting stent (DES)...
April 26, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28474283/hucmncs-protect-vascular-endothelium-and-prevent-isr-after-endovascular-interventional-therapy-for-vascular-diseases-in-t2dm-rabbits
#12
Haixia Ding, Tong Zhang, Yaping Du, Bei Liu, Yueqin Liu, Fujun Wang
The therapeutic effect of transplantation of human umbilical cord blood cell-derived mononuclear cells (HUCMNCs) on treating in-stent restenosis (ISR) after endovascular interventional therapy (EIT) was evaluated in preclinical rabbit model of type 2 diabetes mellitus (T2DM)-related peripheral artery disease (PAD). HUCMNCs were transplanted to T2DM rabbits subjected to femoral artery occlusion surgery and received EIT. Serum concentration of soluble vascular endothelial cadherin (VE-cad) and plasma concentration of lipoprotein-associated phospholipase A2 (Lp-PLA2) were determined with enzyme-linked immunosorbent assay before and after the transplantation...
May 4, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28473813/asunaprevir-evokes-hepatocytes-innate-immunity-to-restrict-the-replication-of-hepatitis-c-and-dengue-virus
#13
Wei-Lun Tsai, Jin-Shiung Cheng, Chih-Wen Shu, Kwok-Hung Lai, Hoi-Hung Chan, Chun-Ching Wu, Jing-Mei Wu, Ping-I Hsu, Raymond T Chung, Tsung-Hsien Chang
Type I Interferon-mediated innate immunity against Flaviviridae, such as Hepatitis C virus (HCV) and Dengue virus (DENV), involves TLR3, RIG-I-like receptor (RLR) and JAK-STAT signal pathways. Asunaprevir is a newly developed HCV protease inhibitor for HCV treatment. Whether, asunaprevir activates innate immunity to restrict viral infection is unclear. Thus, this study investigates the effect of asunaprevir on innate immunity and its influence on HCV and DENV infection. Huh 7.5.1, Hep-G2 cells, JFH-1 infection model, and DENV-2 infection were used for the analysis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28467969/analysis-of-bos-taurus-and-sus-scrofa-x-and-y-chromosome-transcriptome-highlights-reproductive-driver-genes
#14
Faheem Ahmed Khan, Hui Liu, Hao Zhou, Kai Wang, Muhammad Tahir Ul Qamar, Nuruliarizki Shinta Pandupuspitasari, Zhang Shujun
The biology of sperm, its capability of fertilizing an egg and its role in sex ratio are the major biological questions in reproductive biology. To answer these question we integrated X and Y chromosome transcriptome across different species: Bos taurus and Sus scrofa and identified reproductive driver genes based on Weighted Gene Co-Expression Network Analysis (WGCNA) algorithm. Our strategy resulted in 11007 and 10445 unique genes consisting of 9 and 11 reproductive modules in Bos taurus and Sus scrofa, respectively...
April 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28461145/paclitaxel-coated-versus-uncoated-balloon-angioplasty-for-femoropopliteal-artery-in-stent-restenosis
#15
REVIEW
Ridong Wu, Zilun Li, Mian Wang, Guangqi Chang, Chen Yao, Shenming Wang
BACKGROUND: Several prospective controlled trials have assessed the safety and efficacy of drug-coated balloon angioplasty (DCBA) versus standard balloon angioplasty (POBA) for femoropopliteal in-stent restenosis (ISR). We therefore performed a meta-analysis of prospective controlled trials to pool the results of these trials and obtain more reliable conclusions. METHODS AND RESULTS: Prospective controlled trials comparing DCBA versus POBA were searched through PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, ISI Web of Knowledge, and relevant websites without language or publication date restrictions...
April 29, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28455513/role-of-activating-transcription-factor-4-in-the-hepatic-response-to-amino-acid-depletion-by-asparaginase
#16
Rana J T Al-Baghdadi, Inna A Nikonorova, Emily T Mirek, Yongping Wang, Jinhee Park, William J Belden, Ronald C Wek, Tracy G Anthony
The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1). The study objective was to investigate the protective role of activating transcription factor 4 (ATF4) in controlling the hepatic transcriptome and mediating GCN2-mTORC1 signaling during asparaginase. We compared global gene expression patterns in livers from wildtype, Gcn2 (-/-), and Atf4 (-/-) mice treated with asparaginase or excipient and further explored selected responses in livers from Atf4 (+/-) mice...
April 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28455446/enterovirus-71-suppresses-interferon-responses-by-blocking-jak-stat-signaling-through-inducing-karyopherin-%C3%AE-1-degradation
#17
Chunyang Wang, Menghuai Sun, Xinhui Yuan, Lianfu Ji, Yu Jin, Carol J Cardona, Zheng Xing
Enterovirus 71 (EV71) has emerged as one of the most important enteroviruses since the eradication of poliovirus, and causes severe neurological symptoms for which no effective antiviral drugs are available. Type I interferons (IFN-α/β) have been used clinically as antiviral therapy as the first line of defense against virus infections successfully for decades. However, treatment with Type I interferons has not been effective in patients with EV71 infection. In this study, we found that in cells pre-treated with IFN-β, EV71 infection could still lead to a cytopathic effect and the viral replication was not affected...
April 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28455321/nonprocedural-symptomatic-infarction-and-in-stent-restenosis-after-intracranial-angioplasty-and-stenting-in-the-sammpris-trial-stenting-and-aggressive-medical-management-for-the-prevention-of-recurrent-stroke-in-intracranial-stenosis
#18
Colin P Derdeyn, David Fiorella, Michael J Lynn, Tanya N Turan, George A Cotsonis, Bethany F Lane, Jean Montgomery, L Scott Janis, Marc I Chimowitz
BACKGROUND AND PURPOSE: The purpose of this study was to investigate the frequency of symptomatic in-stent restenosis (ISR) and its contribution to nonprocedural symptomatic infarction in the SAMMPRIS trial (Stenting and Aggressive Medical Management for the Prevention of Recurrent Stroke in Intracranial Stenosis). METHODS: Patients without a periprocedural primary end point were followed up to determine the occurrence of any of the following events: ischemic stroke, cerebral infarct with temporary signs, or transient ischemic attack in the territory of the stented artery...
April 28, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28453702/a-phase-2-randomized-double-blind-placebo-%C3%A2-controlled-study-of-chemo-immunotherapy-combination-using-motolimod-with-pegylated-liposomal-doxorubicin-in-recurrent-or-persistent-ovarian-cancer-a-gynecologic-oncology-group-partners-study
#19
B J Monk, M F Brady, C Aghajanian, H A Lankes, T Rizack, J Leach, J M Fowler, R Higgins, P Hanjani, M Morgan, R Edwards, W Bradley, T Kolevska, P Foukas, E M Swisher, K S Anderson, R Gottardo, J K Bryan, M Newkirk, K L Manjarrez, R S Mannel, R M Hershberg, G Coukos
Background: A phase 2, randomized, placebo-controlled trial was conducted in women with recurrent epithelial ovarian carcinoma to evaluate the efficacy and safety of motolimod-a Toll-like receptor 8 (TLR8) agonist that stimulates robust innate immune responses-combined with pegylated liposomal doxorubicin (PLD), a chemotherapeutic that induces immunogenic cell death. Patients and methods: Women with ovarian, fallopian tube, or primary peritoneal carcinoma were randomized 1 : 1 to receive PLD in combination with blinded motolimod or placebo...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28453249/complete-mapping-of-complex-disulfide-patterns-with-closely-spaced-cysteines-by-in-source-reduction-and-data-dependent-mass-spectrometry
#20
Christian Necip Cramer, Christian D Kelstrup, Jesper Velgaard Olsen, Kim F Haselmann, Peter Kresten Nielsen
Mapping of disulfide bonds is an essential part of protein characterization to ensure correct cysteine pairings. For this, mass spectrometry (MS) is the most widely used technique due to fast and accurate characterization. However, MS-based disulfide mapping is challenged when multiple disulfide bonds are present in complicated patterns. This includes presence of disulfide bonds in nested patterns and closely-spaced cysteines. Unambiguous mapping of such disulfide bonds typically requires advanced MS approaches...
April 28, 2017: Analytical Chemistry
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