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Bradley B Stocks, Jeremy E Melanson
Many peptides with antimicrobial activity and/or therapeutic potential contain disulfide bonds as a means to enhance stability, and their quantitation is often performed using electrospray ionization mass spectrometry (ESI-MS). Disulfides can be reduced during ESI under commonly used instrument conditions, which has the potential to hinder accurate peptide quantitation. We demonstrate that this in-source reduction (ISR) is predominantly observed for peptides infused from acidic solutions and subjected to elevated ESI voltages (3-4 kV)...
February 15, 2018: Journal of the American Society for Mass Spectrometry
Mengmeng Yu, Zhigang Lu, Wenbin Li, Meng Wei, Jing Yan, Jiayin Zhang
OBJECTIVES: To assess pre-procedural plaque characteristics as determined by coronary CT angiography (CCTA) and their associations with late revascularization in symptomatic post-procedural patients. METHODS: Symptomatic patients with pre-procedural CCTA were prospectively enrolled and referred for invasive coronary angiography (ICA). Plaque characterization was performed on the basis of baseline CCTA data. Multivariate logistic regression analysis with a stepwise selection method was performed to identify independent predictors of late revascularization...
February 15, 2018: European Radiology
Yiu Tung Anthony Wong, Do-Yoon Kang, Jin Bae Lee, Seung-Woon Rha, Young Joon Hong, Eun-Seok Shin, Sung-Ho Her, Chang Wook Nam, Woo-Young Chung, Moo Hyun Kim, Cheol Hyun Lee, Pil Hyung Lee, Jung-Min Ahn, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Duk-Woo Park, Seung-Jung Park
BACKGROUND: This study sought to evaluate the optimal treatment for in-stent restenosis (ISR) of drug-eluting stents (DESs). METHODS: This is a prospective, multicenter, open-label, randomized study comparing the use of drug-eluting balloon (DEB) versus second-generation everolimus-eluting stent for the treatment of DES ISR. The primary end point was in-segment late loss at 9-month routine angiographic follow-up. RESULTS: A total of 172 patients were enrolled, and 74 (43...
March 2018: American Heart Journal
Björn Redfors, Philippe Généreux, Bernhard Witzenbichler, Akiko Maehara, Giora Weisz, Thomas McAndrew, Roxana Mehran, Ajay J Kirtane, Gregg W Stone
BACKGROUND: There is a paucity of data from large contemporary cohorts of patients with in-stent restenosis (ISR) treated with drug-eluting stents (DESs), and no studies have examined the impact of high platelet reactivity (HPR) on the occurrence of ischemic events after ISR percutaneous coronary intervention (PCI) with DESs. We sought to report outcomes after PCI of ISR lesions and its association with HPR. METHODS: Patients in the prospective, multicenter ADAPT-DES study were stratified according to whether they had ISR versus non-ISR PCI...
March 2018: American Heart Journal
Udit Bhaskar Bhatnagar, Josh Rezkalla, Tomasz Stys, Adam Stys
Drug eluting stents (DES) have been increasingly being used for treatment of coronary artery disease (CAD) and have been shown to be very effective in prevention of primary in-stent restenosis (ISR). However DES have been increasingly associated with acute to subacute risk of stent fractures (SF). There is also a paucity of data about different management strategies for SF, especially in the long term. We present a case of recurrent ISR in an area of previous acute SF at the touchdown of saphenous venous graft (SVG) to first diagonal artery (D1)...
January 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
Charles Nicolais, Vladimir Lakhter, Hafeez Ul Hassan Virk, Partha Sardar, Chirag Bavishi, Brian O'Murchu, Saurav Chatterjee
PURPOSE OF REVIEW: In-stent restenosis (ISR) is a complex disease process that became apparent shortly after the introduction of stents into clinical practice. This review seeks to define in-stent restenosis (ISR) as well as to summarize the major treatment options that have been developed and studied over the past two decades. RECENT FINDINGS: Recent developments in drug-coated balloons and bioresorbable vascular scaffolds have added new potential treatments for ISR...
February 12, 2018: Current Cardiology Reports
Bernardo Cortese, Fabrizio D'Ascenzo, Raffaela Fetiveau, Vruyr Balian, Simonetta Blengino, Massimo Fineschi, Renata Rogacka, Corrado Lettieri, Andrea Pavei, Maurizio D'Amico, Arnaldo Poli, Gaetano Di Palma, Roberto A Latini, Pedro S Orrego, Romano Seregni
AIMS: Drug-coated balloons (DCBs) are a recognized alternative to stents for the treatment of in-stent restenosis (ISR), and there is some initial clinical evidence about their efficacy for the treatment of small coronary vessels. Newer-generation DCBs were developed to overcome the reduced deliverability of the previous generation, also warranting a more effective drug delivery to vessel wall. However, the vast majority of new-generation DCBs still lack of reliability due to paucity of clinical data...
February 9, 2018: Journal of Cardiovascular Medicine
Jun Zhou, Ji Wan, Xin Erica Shu, Yuanhui Mao, Xiao-Min Liu, Xin Yuan, Xingqian Zhang, Martin E Hess, Jens C Brüning, Shu-Bing Qian
The integrated stress response (ISR) facilitates cellular adaptation to stress conditions via the common target eIF2α. During ISR, the selective translation of stress-related mRNAs often relies on alternative mechanisms, such as leaky scanning or reinitiation, but the underlying mechanism remains incompletely understood. Here we report that, in response to amino acid starvation, the reinitiation of ATF4 is not only governed by the eIF2α signaling pathway, but is also subjected to regulation by mRNA methylation in the form of N6-methyladenosine (m6A)...
February 1, 2018: Molecular Cell
Matteo Alicandri-Ciufelli, Pierre Guarino, Filippo Fabbri, Elio Maria Cunsolo, Livio Presutti, Lukas Anschuetz
PURPOSE: To describe the in vivo vascularization of middle ear by an endoscopic point of view, particularly focusing on the medial wall of tympanic cavity and incudostapedial region (ISR). STUDY DESIGN: Case series with surgical videos review and anatomical description. METHODS: 48 videos from exclusive endoscopic middle ear surgery performed at the University Hospital of Modena from November 2015 to July 2017 were reviewed. Data about anatomy of vessels, and blood flow direction (BFD) were collected in an appropriate database for further analyses...
February 10, 2018: European Archives of Oto-rhino-laryngology
Thomas Coral, Michaël Descostes, Hélène De Boissezon, Rizlan Bernier-Latmani, Luiz Felippe de Alencastro, Pierre Rossi
A large fraction (47%) of the world's uranium is mined by a technique called "In Situ Recovery" (ISR). This mining technique involves the injection of a leaching fluid (acidic or alkaline) into a uranium-bearing aquifer and the pumping of the resulting solution through cation exchange columns for the recovery of dissolved uranium. The present study reports the in-depth alterations brought to autochthonous microbial communities during acidic ISR activities. Water samples were collected from a uranium roll-front deposit that is part of an ISR mine in operation (Tortkuduk, Kazakhstan)...
February 8, 2018: Science of the Total Environment
Andrew Mark Bogorad, Kai Ying Lin, Assen Marintchev
The eukaryotic translation initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor (GEF) of the GTPase eIF2, which brings the initiator Met-tRNAi to the ribosome in the form of the eIF2-GTP•Met-tRNAi ternary complex (TC). The activity of eIF2B is inhibited by phosphorylation of its substrate eIF2 by several stress-induced kinases, which triggers the Integrated Stress Response (ISR). ISR plays a central role in maintaining homeostasis in the cell under various stress conditions and its dysregulation is a causative factor in the pathology of a number of neurodegenerative disorders...
February 9, 2018: Biochemistry
Xavier M Chiriboga, Huijuan Guo, Raquel Campos-Herrera, Gregory Röder, Nicola Imperiali, Christoph Keel, Monika Maurhofer, Ted C J Turlings
When larvae of rootworms feed on maize roots they induce the emission of the sesquiterpene (E)-β-caryophyllene (EβC). EβC is attractive to entomopathogenic nematodes, which parasitize and rapidly kill the larvae, thereby protecting the roots from further damage. Certain root-colonizing bacteria of the genus Pseudomonas also benefit plants by promoting growth, suppressing pathogens or inducing systemic resistance (ISR), and some strains also have insecticidal activity. It remains unknown how these bacteria influence the emissions of root volatiles...
February 9, 2018: Oecologia
Giampaolo Niccoli, Domenico D'Amario, Josip A Borovac, Erminio Santangelo, Giancarla Scalone, Francesco Fracassi, Rocco Vergallo, Vincenzo Vetrugno, Giorgia Copponi, Anna Severino, Giovanna Liuzzo, Asiia Imaeva, Andrea Siracusano, Filippo Crea
BACKGROUND: Perilipin 2 (PLIN2) is a protein that potentially facilitates atherogenesis in native coronary arteries or arteries with an implanted drug-eluting stent (DES). The aim of the study was to determine PLIN2 protein levels in peripheral monocytes of enrolled subjects and compare them between patients with native coronary artery disease (CAD) and those with an in-stent restenosis (ISR) due to neoatherosclerosis occurring >1 year after DES implantation. METHODS: Forty-two patients were prospectively enrolled in the study in 3:1 fashion and underwent coronary catheterization...
February 5, 2018: International Journal of Cardiology
Alexandra G Evstafieva, Irina E Kovaleva, Maria S Shoshinova, Andrei V Budanov, Peter M Chumakov
The ATF4 transcription factor is a key regulator of the adaptive integrated stress response (ISR) induced by various stresses and pathologies. Identification of novel transcription targets of ATF4 during ISR would contribute to the understanding of adaptive networks and help to identify novel therapeutic targets. We were previously searching for genes that display an inverse regulation mode by the transcription factors ATF4 and p53 in response to mitochondrial respiration chain complex III inhibition. Among the selected candidates the human genes for cytokeratine 16 (KRT16), anti-apoptotic protein Niban (FAM129A) and hexokinase HKDC1 have been found highly responsive to ATF4 overexpression...
2018: PloS One
Jan Baan, Bimmer E Claessen, Kirsten Boerlage-van Dijk, Jeroen Vendrik, René J van der Schaaf, Martijn Meuwissen, Niels van Royen, A T Marcel Gosselink, Marleen H van Wely, Atilla Dirkali, E Karin Arkenbout, Robbert J de Winter, Karel T Koch, Krischan D Sjauw, Marcel A Beijk, M Marije Vis, Joanna J Wykrzykowska, Jan J Piek, Jan G P Tijssen, José P S Henriques
OBJECTIVES: The authors sought to evaluate the relative performance of a drug-eluting balloon (DEB) and a drug-eluting stent (DES) in patients with any (bare-metal or drug-eluting stent) in-stent restenosis (ISR). BACKGROUND: The treatment of ISR remains challenging in contemporary clinical practice. METHODS: In a multicenter randomized noninferiority trial, patients with any ISR were randomly allocated in a 1:1 fashion to treatment with a DEB (SeQuent Please paclitaxel-eluting balloon, B...
February 12, 2018: JACC. Cardiovascular Interventions
Kristjan K Stefansson, Steinunn Gestsdottir, Freyja Birgisdottir, Richard M Lerner
Students' gradual disconnection from school in adolescence, as reflected in decreased school engagement, has been demonstrated in several cultures and is of great concern to educators. At the same time, intentional self-regulation (ISR) has been shown to be a precursor, mediator, and outcome of school engagement. However, the relation between school engagement and ISR during adolescence is poorly understood. In this research, we explored the reciprocal relation between school engagement and ISR during adolescence...
January 26, 2018: Journal of Adolescence
Ashish Bavdekar, Jitendra Oswal, Padmasani Venkat Ramanan, Chandrashekhar Aundhkar, P Venugopal, Dhananjay Kapse, Tara Miller, Sarah McGray, Darin Zehrung, Prasad S Kulkarni
BACKGROUND: We conducted a randomized, non-inferiority, clinical study of MMR vaccine by a disposable-syringe jet injector (DSJI) in toddlers in India in comparison with the conventional administration. METHODS: MMR vaccine was administered subcutaneously by DSJI or needle-syringe (N-S) to toddlers (15-18 months) who had received a measles vaccine at 9 months. Seropositivity to measles, mumps, and rubella serum IgG antibodies was assessed 35 days after vaccination...
January 29, 2018: Vaccine
Takaaki Matsudo, Kenji Katsumata, Masanobu Enomoto, Kenta Kasahara, Hiroshi Kuwabara, Masatoshi Shigoka, Tetsuo Ishizaki, Masayuki Hisada, Tetsuo Sumi, Akihiko Tsuchida
PURPOSE: This study aimed to consider the oncological validity of intersphincteric resection(hereinafter referred to as ISR) performed at Tokyo Medical University Hospital, as well as associated dysfunction. SUBJECTS: Subjects included 73 cases in which ISR was performed at Tokyo Medical University Hospital between November 2004 and January 2016. RESULTS: The 5- year overall and relapse-free survival rates for cases with Stage 0 to III were 90...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Asier Ruiz, Elena Alberdi, Carlos Matute
Excessive dynamin related protein 1 (Drp1)-triggered mitochondrial fission contributes to apoptosis under pathological conditions and therefore it has emerged as a promising therapeutic target. Mitochondrial division inhibitor 1 (mdivi-1) inhibits Drp1-dependent mitochondrial fission and is neuroprotective in several models of brain ischemia and neurodegeneration. However, mdivi-1 also modulates mitochondrial function and oxidative stress independently of Drp1, and consequently the mechanisms through which it protects against neuronal injury are more complex than previously foreseen...
2018: Frontiers in Molecular Neuroscience
Sijing Wu, Wei Liu, Yonghe Guo, Yaping Zeng, Zhiming Zhou, Yingxin Zhao, Yuyang Liu, Dongmei Shi, Zhijian Wang, Hailong Ge, Jianlong Wang, Peng Jin, Yujie Zhou
The aim of the study was to investigate the optical coherence tomography (OCT)-identified difference of in-stent restenosis (ISR) tissue characteristics between patients with and without acute coronary syndrome (ACS) at index intervention.The retrospective study included 80 patients with 85 drug-eluting stent (DES) restenosis lesions. Subjects were classified according to clinical presentation at the time of de-novo lesion intervention, namely ACS and non-ACS. OCT was performed at 5 years follow-up. The frequency of malapposition, neointimal characteristics, thrombus, and minimal stent area (MSA) were evaluated...
December 2017: Medicine (Baltimore)
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