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https://www.readbyqxmd.com/read/29237330/influence-of-cationic-polyacrilamide-flocculant-on-high-solids-anaerobic-digestion-of-sewage-sludge-under-thermophilic-condition
#1
Yuri Litti, Anna Nikitina, Dmitriy Kovalev, Artem Ermoshin, Rishi Mahajan, Gunjan Goel, Alla Nozhevnikova
Treatment of sewage sludge (SS) by biodegradable polyacrylamide-based flocculants (PAM) is considered to be an effective way to increase total solids (TS) content prior to anaerobic digestion (AD). However, data on how PAM addition influences the efficiency of AD process are quite contradictory; moreover no data is available for thermophilic AD (TAD). This study showed that at optimal inoculum to substrate ratio (ISR, 55/45), PAM addition resulted in some decrease in initial methane production during TAD of SS due to formation of large flocs (up to 2-3 mm in diameter) which deteriorated the mass transfer...
December 14, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29234061/evaluation-of-promoting-effect-of-a-novel-cu-bearing-metal-stent-on-endothelialization-process-from-in-vitro-and-in-vivo-studies
#2
Shujing Jin, Xun Qi, Bin Zhang, Ziqing Sun, Bingchun Zhang, Hui Yang, Tongmin Wang, Bo Zheng, Xingang Wang, Qiuping Shi, Ming Chen, Ling Ren, Ke Yang, Hongshan Zhong
Drug eluting stents (DES) have been extensively applied nowadays and reduce the incidence of in-stent restenosis (ISR) greatly as compared with bare metal stents (BMS). However, the development of DES is hindered by the risk of late stent thrombosis (LST) due to delayed re-endothelialization, while endothelialization is an important process related to ISR and LST after implantation. 316L is a traditional stent material without bioactivity and have a high risk of ISR. Cu is recognized for angiogenesis stimulation in these years...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29232537/laparoscopic-versus-conventional-open-surgery-in-intersphincteric-resection-for-low-rectal-cancer-a-systematic-review-and-meta-analysis
#3
Xubing Zhang, Qingbin Wu, Tao Hu, Chaoyang Gu, Liang Bi, Ziqiang Wang
AIM: This meta-analysis aims at comparing laparoscopic intersphincteric resection (LISR) with conventional open ISR (OISR) for low rectal cancer (LRC) in terms of intraoperative, postoperative, pathological, and survival outcomes. MATERIALS AND METHODS: A systematic literature search with no limits was performed in PubMed and Ovid. The last search was performed on May 27, 2017. The outcomes of interests included intraoperative outcomes: operative time and blood loss; postoperative outcomes: hospital day, postoperative hospital day, time to first flatus, time to normal diet, ileus, intra-abdominal abscess, anastomotic leakage, anastomotic stricture, wound infection, pneumonia, urinary complication, morbidity, and mortality; pathological outcomes: lymph node harvested, R0 resection rate, distance of proximal resection margin, distal resection margin and circumferential resection margin (CRM), and positive CRM; survival outcomes: 3-year overall survival (OS), 3-year disease-free survival (DFS), 5-year OS, and 5-year DFS...
December 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29229615/defective-amplifying-pathway-of-%C3%AE-cell-secretory-response-to-glucose-in-type-2-diabetes-integrated-modeling-of-in-vitro-and-in-vivo-evidence
#4
Eleonora Grespan, Toni Giorgino, Silva Arslanian, Andrea Natali, Ele Ferrannini, Andrea Mari
In vivo studies have investigated the role of β-cell dysfunction in type 2 diabetes (T2D), while in vitro research on islets has elucidated key mechanisms controlling insulin secretion rate (ISR). However, the relevance of the cellular mechanisms identified in vitro, i.e., the triggering and amplifying pathways, has not been established in vivo Furthermore, the mechanisms underpinning β-cell dysfunction in T2D remain undetermined. We propose a unifying explanation of several characteristic features of insulin secretion, both in vitro and in vivo, using a mathematical model...
December 11, 2017: Diabetes
https://www.readbyqxmd.com/read/29226890/relationship-between-the-extent-of-coronary-artery-disease-and-in-stent-restenosis-in-patients-with-acute-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#5
Erkan Yıldırım, Murat Çelik, Uygar Çağdaş Yüksel, Barış Buğan, Yalçın Gökoğlan, Suat Görmel, Salim Yaşar, Mustafa Koklu, Atila İyisoy, Cem Barçın
OBJECTIVE: The pathophysiological mechanism of in-stent restenosis (ISR) is different from atherosclerosis of native coronary arteries. The aim of this study was to evaluate the relationship between ISR and the extent of coronary artery disease (CAD), and to identify other risk factors associated with ISR in ST-segment elevation myocardial infarction (STEMI) patients. METHODS: A total of 372 consecutive patients presenting with first acute STEMI who were successfully treated with primary percutaneous coronary intervention within 12 hours from the onset of symptoms and who had an angiographic follow-up at 3 months were included in the study...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29222490/ran-translation-at-c9orf72-associated-repeat-expansions-is-selectively-enhanced-by-the-integrated-stress-response
#6
Katelyn M Green, M Rebecca Glineburg, Michael G Kearse, Brittany N Flores, Alexander E Linsalata, Stephen J Fedak, Aaron C Goldstrohm, Sami J Barmada, Peter K Todd
Repeat-associated non-AUG (RAN) translation allows for unconventional initiation at disease-causing repeat expansions. As RAN translation contributes to pathogenesis in multiple neurodegenerative disorders, determining its mechanistic underpinnings may inform therapeutic development. Here we analyze RAN translation at G4C2 repeat expansions that cause C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia (C9RAN) and at CGG repeats that cause fragile X-associated tremor/ataxia syndrome...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29222027/tbk1-from-orange-spotted-grouper-exerts-antiviral-activity-against-fish-viruses-and-regulates-interferon-response
#7
Yin Hu, Youhua Huang, Jiaxin Liu, Jingcheng Zhang, Qiwei Qin, Xiaohong Huang
TANK-binding kinase-1 (TBK1) has been well studied in mammals because of its importance in type I interferon induction in antiviral immunity. However, the roles of fish TBK1 in virus infection still remained largely uncertain. In the current study, a TBK1 homolog from orange-spotted grouper (Epinephelus coioides) (EcTBK1) was cloned and its roles in fish viral infections were investigated. Sequence analysis showed that EcTBK1 encoded a 723-amino acid peptide which shared 98% and 73% identity to large yellow croaker (Larimichthys crocea) and human (homo sapiens), respectively...
December 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29220654/a-unique-isr-program-determines-cellular-responses-to-chronic-stress
#8
Bo-Jhih Guan, Vincent van Hoef, Raul Jobava, Orna Elroy-Stein, Leos S Valasek, Marie Cargnello, Xing-Huang Gao, Dawid Krokowski, William C Merrick, Scot R Kimball, Anton A Komar, Antonis E Koromilas, Anthony Wynshaw-Boris, Ivan Topisirovic, Ola Larsson, Maria Hatzoglou
The integrated stress response (ISR) is a homeostatic mechanism induced by endoplasmic reticulum (ER) stress. In acute/transient ER stress, decreased global protein synthesis and increased uORF mRNA translation are followed by normalization of protein synthesis. Here, we report a dramatically different response during chronic ER stress. This chronic ISR program is characterized by persistently elevated uORF mRNA translation and concurrent gene expression reprogramming, which permits simultaneous stress sensing and proteostasis...
December 7, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29220547/impact-of-moderate-alcohol-discontinuation-on-insulin-action-and-secretion-in-latinos-with-and-without-hepatitis-c
#9
Lindsay A Uribe, Peter Bacchetti, Nicholas Gelman, Esteban Burchard, Mark Fitch, Marc Hellerstein, Mandana Khalili
BACKGROUND/AIMS: Insulin resistance (IR) is associated with hepatitis C infection (HCV), and Latinos are both at risk for IR and are disproportionately affected by HCV. Moderate alcohol consumption improves insulin sensitivity and may modify HCV-associated IR. We investigated the impact of moderate alcohol discontinuation on insulin sensitivity and secretion in Latinos using direct measurements. METHODS: Twenty-five non-diabetic, non-cirrhotic Latino adults without (n=17) or with (n=8) HCV underwent 3-day metabolic assessment before and after prescription of 6 weeks of moderate alcohol discontinuation...
December 8, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29219030/laser-atherectomy-combined-with-drug-coated-balloon-angioplasty-is-associated-with-improved-1-year-outcomes-for-treatment-of-femoropopliteal-in-stent-restenosis
#10
Damianos G Kokkinidis, Prio Hossain, Omar Jawaid, Bejan Alvandi, T Raymond Foley, Gagan D Singh, Stephen W Waldo, John R Laird, Ehrin J Armstrong
PURPOSE: To examine whether laser atherectomy combined with drug-coated balloons (laser + DCB) can improve the outcomes of femoropopliteal (FP) in-stent restenosis (ISR). METHODS: A dual-center retrospective study was conducted of 112 consecutive patients (mean age 70.3±10.6 years; 86 men) with Tosaka class II (n=29; diffuse stenosis) or III (n=83; occlusion) FP-ISR lesions. Sixty-two patients (mean age 68.5±10 years; 51 men) underwent laser + DCB while the other 50 patients (mean age 72...
December 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29216314/clinical-outcomes-in-patients-treated-for-coronary-in-stent-restenosis-with-drug-eluting-balloons-impact-of-high-platelet-reactivity
#11
Adrienn Tornyos, Dániel Aradi, Iván G Horváth, Attila Kónyi, Balázs Magyari, Tünde Pintér, András Vorobcsuk, Dániel Tornyos, András Komócsi
BACKGROUND: The impact of high platelet reactivity (HPR) on clinical outcomes after elective percutaneous coronary interventions (PCI) with drug-eluting balloons (DEB) due to in-stent restenosis (ISR) is unknown. OBJECTIVE: We sought to evaluate the prognostic importance of HPR together with conventional risk factors in patients treated with DEB. METHODS: Patients treated with DEB due to ISR were enrolled in a single-centre, prospective registry between October 2009 and March 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29214713/stent-graft-treatment-for-infra-inguinal-arterial-disease-for-either-instent-restenosis-and-denovo-lesions-associated-with-very-high-rates-of-failure
#12
Maheswara S Golla, Subasit Acharji, Timir K Paul, Praveena Madapathi, Lawrence A Garcia
BACKGROUND: FDA approved the Gore Viabahn (WL Gore, Flagstaff, AZ, USA) stent for both femoro-popliteal arterial denovo and instent restenosis (ISRS) lesions. To date there is little data on Viabahn stent graft outcomes in ISRS arterial disease. METHODS: Between 2007 and 2014 we identified 734 patients who underwent 1573 endovascular interventions in our institution for infra-inguinal revascularization. Among these, 48 patients had 143 Viabahn stents placed. Of these, 26 patients had 94 stents placed for ISRS and 22 patients had 49 stents placed for denovo lesions...
December 7, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29212034/gadd34-function-in-protein-trafficking-promotes-adaptation-to-hyperosmotic-stress-in-human-corneal-cells
#13
Dawid Krokowski, Bo-Jhih Guan, Jing Wu, Yuke Zheng, Padmanabhan P Pattabiraman, Raul Jobava, Xing-Huang Gao, Xiao-Jing Di, Martin D Snider, Ting-Wei Mu, Shijie Liu, Brian Storrie, Eric Pearlman, Anna Blumental-Perry, Maria Hatzoglou
GADD34, a stress-induced regulatory subunit of the phosphatase PP1, is known to function in hyperosmotic stress through its well-known role in the integrated stress response (ISR) pathway. Adaptation to hyperosmotic stress is important for the health of corneal epithelial cells exposed to changes in extracellular osmolarity, with maladaptation leading to dry eye syndrome. This adaptation includes induction of SNAT2, an endoplasmic reticulum (ER)-Golgi-processed protein, which helps to reverse the stress-induced loss of cell volume and promote homeostasis through amino acid uptake...
December 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/29208498/identification-and-functional-characterization-of-interferon-regulatory-factor-7-involved-in-activation-jak-stat-pathway-in-miiuy-croaker
#14
Yuena Sun, Qiong Yang, Xueyan Zhao, Xuezhu Liu, Tianjun Xu
Interferon regulatory factor (IRF) family is a transcription factor family which plays an important role in the regulation of natural immunity and immune cell differentiation. IRF7 is important to regulate the response of type I interferon (IFN) to viral infection. Thus, more researches of the characteristic and functions of IRF7 should be done to get better understanding of the mechanisms underlying immune reactions. Here, the characterization of full-length cDNA of IRF7 was reported from miiuy croaker. Gene characterization analysis of mmiIRF7 showed conservative with other fish and inferred that the difference of tryptophan residues in IRF7 may occurred in the period of fish-specific genome duplication (FSGD) or earlier...
December 2, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29203976/laparoscopic-versus-open-approach-for-intersphincteric-resection-results-from-a-tertiary-cancer-center-in-india
#15
Vishwas D Pai, Pavan Sugoor, Prachi S Patil, Vikas Ostwal, Reena Engineer, Supreeta Arya, Ashwin Desouza, Avanish P Saklani
The study aims to compare open intersphincteric resection (OISR) with laparoscopic intersphincteric resection (LISR) in terms of short-term oncological and clinical outcomes. This is a retrospective review of a prospectively maintained database including all the patients of rectal cancer who underwent intersphincteric resection (ISR) at Tata Memorial Centre between 1st July 2013 and 30th November 2015. Short-term oncological parameters evaluated included circumferential resection margin involvement (CRM), distal resection margin involvement, and number of nodes harvested...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203973/long-term-functional-and-oncological-outcomes-following-intersphincteric-resection-for-low-rectal-cancers
#16
Sivakumar Mahalingam, Ramakrishnan Ayloor Seshadri, Surendran Veeraiah
Surgery for low rectal cancer often involves a permanent stoma. Intersphincteric resection (ISR) with colo-anal anastomosis is a valuable sphincter sparing surgical procedure that avoids the need for permanent stoma in patients with low rectal cancer. The aim of this study was to analyze the long-term functional and oncological outcomes following ISR. This was a retrospective analysis of patients with low rectal cancer who underwent ISR with colo-anal anastomosis in our institution between 2007 and 2015. All patients had a diversion stoma...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203209/comparative-efficacy-of-two-paclitaxel-coated-balloons-with-different-excipient-coatings-in-patients-with-coronary-in-stent-restenosis-a-pooled-analysis-of-the-intracoronary-stenting-and-angiographic-results-optimizing-treatment-of-drug-eluting-stent-in-stent
#17
Roisin Colleran, Michael Joner, Sebastian Kufner, Felix Altevogt, Franz-Josef Neumann, Mohamed Abdel-Wahab, Janika Bohner, Christian Valina, Gert Richardt, Bernhard Zrenner, Salvatore Cassese, Tareq Ibrahim, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Robert A Byrne
BACKGROUND: Angioplasty with paclitaxel-coated balloons (PCB) is recommended for treatment of patients with coronary in-stent restenosis (ISR) according to European clinical practice guidelines. Most clinical trials have investigated iopromide-based PCB and there is a paucity of data comparing efficacy against butyryl-tri-hexyl citrate (BTHC)-based PCB. Our aim was to compare the performance of two widely-used PCB in the treatment of coronary ISR. METHODS: We analysed patients treated with BTHC- or iopromide-PCB for treatment of drug-eluting stent ISR in the setting of 2 consecutive trials with identical inclusion and exclusion criteria...
November 28, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29196782/adapting-to-insulin-resistance-in-obesity-role-of-insulin-secretion-and-clearance
#18
Sang-Hee Jung, Chan-Hee Jung, Gerald M Reaven, Sun H Kim
AIMS/HYPOTHESIS: The aim of this study was to quantify the relative contributions of increased insulin secretion rate (ISR) and decreased insulin clearance rate (ICR) in the compensatory hyperinsulinaemia characteristic of insulin-resistant individuals without diabetes. METHODS: Obese (BMI ≥30 kg/m2) individuals without diabetes (n = 91) were identified from a registry of volunteers. Volunteers underwent the following measurements: oral glucose tolerance; insulin resistance (steady-state plasma glucose [SSPG] concentration during the insulin suppression test [IST]); ISR (using the graded glucose infusion test [GGIT]); and ICR (using the IST and GGIT)...
December 1, 2017: Diabetologia
https://www.readbyqxmd.com/read/29191532/the-incidence-and-risk-factors-of-in-stent-restenosis-for-vertebrobasilar-artery-stenting
#19
Dai Zheng, Zhu Mingyue, Shi Wei, Li Min, Chen Wanhong, Dai Qiliang, Jiang Yongjun, Liu Xinfeng
BACKGROUND AND OBJECTIVES: In-stent restenosis (ISR) remains a challenge for vertebrobasilar artery stenting (VBAS). We aimed to investigate the incidence and risk factors of ISR. METHODS: This was a retrospective study. From July 28, 2005 to July 30, 2015, patients who received VBAS with an angiographic follow-up at 6-12 months after surgery were enrolled. The clinical and angiographic issues were recorded and analyzed. RESULTS: In total, 283 patients with 335 stents were incorporated into the study...
November 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29174682/herpes-zoster-vaccine-live-a-10%C3%A2-year-review-of-post-marketing-safety-experience
#20
English D Willis, Meredith Woodward, Elizabeth Brown, Zoran Popmihajlov, Patricia Saddier, Paula W Annunziato, Neal A Halsey, Anne A Gershon
BACKGROUND: Zoster vaccine is a single dose live, attenuated vaccine (ZVL) indicated for individuals ≥50 years-old for the prevention of herpes zoster (HZ). Safety data from clinical trials and post-licensure studies provided reassurance that ZVL is generally safe and well tolerated. The objective of this review was to provide worldwide post-marketing safety information following 10 years of use and >34 million doses distributed. METHODS: All post-marketing adverse experience (AE) reports received worldwide between 02-May-2006 and 01-May-2016 from healthcare professionals following vaccination with ZVL and submitted to the MSD AE global safety database, were analyzed...
December 19, 2017: Vaccine
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