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https://www.readbyqxmd.com/read/28095207/the-constitutive-endopolygalacturonase-tvpg2-regulates-the-induction-of-plant-systemic-resistance-by-trichoderma-virens
#1
Sabrina Sarrocco, Fabiola Matarese, Riccardo Baroncelli, Giovanni Vannacci, Verena Seidl-Seiboth, Christian Peter Kubicek, Mariarosaria Vergara
Trichoderma spp. are opportunistic fungi some of which are commonly present in the rhizosphere. Several species, such as Trichoderma virens, are also efficient biocontrol agents against phytopathogenic fungi and exert beneficial effects on plants. These effects are the consequence of interactions between Trichoderma and plant roots, which trigger enhanced plant growth and induce plant resistance. We have previously shown that T. virens I10 expresses two endopolygalacturonase genes, tvpg1 and tvpg2, during the interaction with plant roots; tvpg1 is inducible while tvpg2 is constitutively transcribed...
January 17, 2017: Phytopathology
https://www.readbyqxmd.com/read/28091845/comparison-of-the-clinical-results-of-abdominoperanal-intersphincteric-resection-and-abdominoperineal-resection-for-lower-rectal-cancer
#2
Shunsuke Tsukamoto, Yukihide Kanemitsu, Dai Shida, Hiroki Ochiai, Junichi Mazaki
BACKGROUND: The aim of this study was to compare the oncologic results of abdominoperanal intersphincteric resection (ISR) and abdominoperineal resection (APR). METHODS: Between 2003 and 2014, 277 consecutive patients with stage I-III low rectal cancer located within 5 cm from the anal verge underwent curative ISR and APR. A retrospective comparison of these two procedures was performed. RESULTS: Overall, 128 patients underwent ISR and 149 underwent APR...
January 16, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28089147/sequent-please-vs-pantera-lux-drug-coated-balloon-angioplasty-in-real-life-results-from-the-d%C3%A3-sseldorf-dcb-registry
#3
Athena Assadi-Schmidt, Annemarie Mohring, Eva Liebsch, Lisa Dannenberg, Alina Achilles, Martin Pöhl, Shazia Afzal, Verena Veulemans, Patrick Horn, Roberto Sansone, Florian Bönner, Bodo Levkau, Malte Kelm, Tobias Zeus, Amin Polzin
BACKGROUND: In-stent restenosis (ISR) is still a major concern in interventional cardiology. Drug coated balloon (DCB) angioplasty has been shown to be a promising option in treatment of ISR. However heterogeneity of different DCBs in suppression of neointimal growth has been described in a porcine model of coronary ISR. Therefore, in this registry analysis, we compared two frequently used paclitaxel eluting DCBs, the SeQuent Please and the Pantera Lux DCB. METHODS: 571 patients were treated with DCB angioplasty at the Heinrich-Heine University Düsseldorf between 2009 and 2012...
December 13, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28071330/subcutaneous-peginterferon-%C3%AE-1a-injection-site-reaction-experience-and-mitigation-delphi-analysis-of-the-allow-study
#4
Barry Hendin, DeRen Huang, Sibyl Wray, Robert T Naismith, Sheri Rosenblatt, Javier Zambrano, Brian Werneburg
AIM: The objective of this Delphi analysis was to obtain consensus on injection-site reaction (ISR) experience and mitigation strategies for patients with relapsing-remitting multiple sclerosis switching from nonpegylated interferons (IFNs) to peginterferon β-1a in the ALLOW Phase IIIb trial using a three-step approach. METHODS: Study investigators and coordinators from investigative sites enrolling four or more patients in ALLOW participated in three rounds of questionnaires and interviews...
January 10, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28068799/is-in-stent-restenosis-after-a-successful-coronary-stent-implantation-due-to-stable-angina-associated-with-tg-hdl-c-ratio
#5
Harun Kundi, Ahmet Korkmaz, Ahmet Balun, Hulya Cicekcioglu, Emrullah Kiziltunc, Koray Gursel, Mustafa Cetin, Ender Ornek, Mehmet Ileri
We examined the impact of the preprocedural triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio on risk of in-stent restenosis (ISR). Patients with typical anginal symptoms and/or positive treadmill or myocardial perfusion scintigraphy test results who underwent successful coronary stent implantation due to stable angina were examined; 1341 patients were enrolled. The hospital files of the patients were used to gather data. Cox regression analysis showed that the TG/HDL-C ratio was independently associated with the presence of ISR ( P < ...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28061808/effect-of-diabetes-mellitus-on-long-term-outcomes-after-repeat-drug-eluting-stent-implantation-for-in-stent-restenosis
#6
Lin Zhao, Weiwei Zhu, Xiaojiang Zhang, Dongfang He, Chengjun Guo
BACKGROUND: Whether diabetes mellitus (DM) is a predictor of long-term adverse clinical outcomes after repeat drug eluting stent (DES) implantation for DES in-stent restenosis (ISR) remains controversial. We sought to evaluate the effect of DM on the long-term clinical outcomes in patients undergoing repeat DES implantation for DES-ISR lesions. METHODS: In the present study, 254 patients with DES-ISR were divided into DM or non-DM groups according to the presence or absence of DM...
January 6, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28057086/diagnostic-value-of-microrna-143-in-predicting-in-stent-restenosis-for-patients-with-lower-extremity-arterial-occlusive-disease
#7
Zhi-Hai Yu, Hai-Tao Wang, Can Tu
PURPOSE: This study was conducted to explore the diagnostic value of microRNA-143 (miRNA-143) in predicting in-stent restenosis (ISR) of lower extremity arterial occlusive disease (LEAOD). METHODS: From February 2012 to March 2015, 165 patients (112 males and 53 females) with LEAOD undergoing interventional treatment were enrolled in this study. Serum miRNA-143 expression was detected using quantitative real-time polymerase chain reaction (qRT-PCR). Patients were assigned into the restenosis and non-restenosis groups according to routine surveillance postoperative angiography...
January 5, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28055140/eif2s3-mutations-associated-with-severe-x-linked-intellectual-disability-syndrome-mehmo
#8
Martina Skopkova, Friederike Hennig, Byung-Sik Shin, Clesson E Turner, Daniela Stanikova, Katarina Brennerova, Juraj Stanik, Ute Fischer, Lyndal Henden, Ulrich Müller, Daniela Steinberger, Esther Leshinsky-Silver, Armand Bottani, Timea Kurdiova, Jozef Ukropec, Olga Nyitrayova, Miriam Kolnikova, Iwar Klimes, Guntram Borck, Melanie Bahlo, Stefan A Haas, Joo-Ran Kim, Leda E Lotspeich-Cole, Daniela Gasperikova, Thomas E Dever, Vera M Kalscheuer
Impairment of translation initiation and its regulation within the integrated stress response (ISR) and related unfolded-protein response has been identified as a cause of several multi-systemic syndromes. Here we link MEHMO syndrome, whose genetic etiology was unknown, to this group of disorders. MEHMO is a rare X-linked syndrome characterized by profound intellectual disability, epilepsy, hypogonadism, and hypogenitalism, microcephaly, and obesity. We have identified a C-terminal frameshift mutation (Ile465Serfs) in the EIF2S3 gene in three families with MEHMO syndrome and a novel maternally inherited missense EIF2S3 variant (c...
January 5, 2017: Human Mutation
https://www.readbyqxmd.com/read/28045929/detecting-the-hormonal-pathways-in-oilseed-rape-behind-induced-systemic-resistance-by-trichoderma-harzianum-th12-to-sclerotinia-sclerotiorum
#9
Jawadayn Talib Alkooranee, Tamarah Raad Aledan, Ali Kadhim Ali, Guangyuan Lu, Xuekun Zhang, Jiangsheng Wu, Chunhua Fu, Maoteng Li
Plants have the ability to resist pathogen attack after infection or treatment with biotic and abiotic elicitors. In oilseed rape plant Brassica napus AACC and in the artificially synthesized Raphanus alboglabra RRCC, the root-colonizing Trichoderma harzianum TH12 fungus triggers induced systemic resistance (ISR), and its culture filtrate (CF) triggers a systemic acquired resistance (SAR) response against infection by the Sclerotinia sclerotiorum. Salicylic acid (SA) and jasmonic acid/ethylene (JA/ET) are plant hormone signals that play important roles in the regulation of ISR and SAR...
2017: PloS One
https://www.readbyqxmd.com/read/28044987/drug-eluting-stents-versus-bare-metal-stents-for-the-prevention-of-restenosis-in-patients-with-renovascular-disease
#10
Christian Bradaric, Kristin Eser, Stephanie Preuss, Michael Dommasch, Isabell Wustrow, Nicolas Langwieser, Bernhard Haller, Ilka Ott, Massimiliano Fusaro, Uwe Heemann, Karl-Ludwig Laugwitz, Adnan Kastrati, Tareq Ibrahim
AIMS: To assess the impact of drug-eluting stents (DES) compared to bare-metal stents (BMS) for the endovascular treatment of atherosclerotic renal artery stenosis (ARAS). METHODS AND RESULTS: We retrospectively evaluated all of our endovascular BMS- and DES-implantations performed in de- novo ARAS between 2000-2014 at our institution. The occurrence of in-stent restenosis (ISR) detected by ultrasound or angiography, kidney function, blood pressure (BP), and the number of antihypertensive drugs were analyzed as endpoints...
January 3, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28043660/comparison-of-outcomes-after-treatment-of-in-stent-restenosis-using-newer-generation-drug-eluting-stents-versus-drug-eluting-balloon-patient-level-pooled-analysis-of-korean-multicenter-in-stent-restenosis-registry
#11
Joo Myung Lee, Tae-Min Rhee, Joo-Yong Hahn, Doyeon Hwang, Jonghanne Park, Kyung Woo Park, Hack-Lyoung Kim, Sang-Hyun Kim, In-Ho Chae, Joon-Hyung Doh, Ki-Hyun Jeon, Young Jin Choi, Jin Sik Park, Seung-Hyuck Choi, Hyeon-Cheol Gwon, Bon-Kwon Koo, Fernando Alfonso, Hyo-Soo Kim
BACKGROUND: Studies comparing the drug-eluting balloon (DEB) with contemporary drug-eluting stent (DES) in the treatment of in-stent restenosis (ISR) have been scarce. We compared that the efficacy and safety of contemporary DES versus DEB in unselected, real world patients of ISR occurred in bare-metal stent or DES. METHODS: Patient-level pooled analysis from nationwide multicenter registries was performed with 628 consecutive patients who underwent ISR treatment using 2nd or 3rd generation DES or DEB...
December 29, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28039033/identification-of-an-irf-1-splicing-transcript-in-apl-cells-sharing-similar-transactivation-activity-of-the-full-length-one
#12
Yejiang Lou, Di Xia, Mengxia Yu, Jianhua Tong, Jie Jin
Interferon regulatory factor-1 (IRF-1) is a member of the interferon regulatory factor family. It acts as a transcriptional activator and plays a critical role in antiviral defense, immune response, cell growth regulation, apoptosis and cell differentiation. Deletions, mutations or aberrant splicing of IRF-1 would result in its functional inactivation, and closely related to the tumorigenesis. In this work, we identified an IRF-1 splicing transcript (IRF-1-s) in all-trans retinoic acid (ATRA)-treated acute promyelocytic leukemia (APL) cell line NB4 cells...
December 27, 2016: Gene
https://www.readbyqxmd.com/read/28000428/dissecting-the-relationship-between-obesity-and-hyperinsulinemia-role-of-insulin-secretion-and-insulin-clearance
#13
Mee Kyoung Kim, Gerald M Reaven, Sun H Kim
OBJECTIVE: The aim of this study was to better delineate the complex interrelationship among insulin resistance (IR), secretion rate (ISR), and clearance rate (ICR) to increase plasma insulin concentrations in obesity. METHODS: Healthy volunteers (92 nondiabetic individuals) had an insulin suppression test to measure IR and graded-glucose infusion test to measure ISR and ICR. Obesity was defined as a body mass index (BMI) ≥30 kg/m(2) , and IR was defined as steady-state plasma glucose (SSPG) ≥10 mmol/L during the insulin suppression test...
December 21, 2016: Obesity
https://www.readbyqxmd.com/read/27995259/on-the-accuracy-of-the-general-state-specific-polarizable-continuum-model-for-the-description-of-correlated-ground-and-excited-states-in-solution
#14
Jan-Michael Mewes, John M Herbert, Andreas Dreuw
Equilibrium and non-equilibrium formulations of the state-specific polarizable-continuum model (SS-PCM) are evaluated in combination with correlated ground- and excited-state densities provided by the algebraic-diagrammatic construction method (ADC) for the polarization propagator via the computationally efficient intermediate-state representation (ISR) formalism. Since the influence of the SS-PCM onto quantum-chemical method is naturally limited to the presence of the apparent surface charges in the one-electron Hamiltonian and hence fully contained in the polarized MOs, the herein presented solvent model can be combined with all implemented orders and variants of ADC...
January 4, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27993757/percutaneous-intervention-in-chronic-total-coronary-occlusions-caused-by-in-stent-restenosis-procedural-results-and-long-term-clinical-outcomes-in-the-toro-spanish-registry-of-chronic-total-occlusion-secondary-to-an-occlusive-in-stent-restenosis-multicenter
#15
José M de la Torre Hernandez, José R Rumoroso, Asier Subinas, Nieves Gonzalo, Soledad Ojeda, Manuel Pan, Victoria Martín Yuste, Alfonso Suárez, Felipe Hernández, Luis Teruel, José Moreu, José M Cubero, José D Cascón, Hugo Vinhas, Íñigo Lozano, Javier Martin Moreiras, Armando Pérez de Prado, Javier Goicolea, Javier Escaned
AIMS: Limited data exist on the treatment and outcomes of patients with chronic total occlusions due to in-stent restenosis (CTO-ISR). We sought to evaluate results and clinical outcomes in percutaneous interventions over CTO-ISR. METHODS AND RESULTS: Registry in 16 centers involving consecutive patients undergoing attempt of percutaneous intervention over CTO-ISR. A total of 233 patients were included, 192 (82.4%) with successful acute result. Success rate was significantly lower in patients with: lesion in circumflex artery, ostial lesion, J score > 3 and no femoral access...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27989217/long-term-safety-and-tolerability-of-glatiramer-acetate-20-mg-in-the-treatment-of-relapsing-forms-of-multiple-sclerosis
#16
Tjalf Ziemssen, Natalia Ashtamker, Svetlana Rubinchick, Volker Knappertz, Giancarlo Comi
Glatiramer acetate (GA) is a first-line therapy for the treatment of relapsing-remitting multiple sclerosis (RRMS). It has a well-characterized long-term safety profile and established efficacy, with over 2 million patient-years of exposure. Areas Covered: To present long-term safety and tolerability findings for GA 20 mg/mL daily in the management of patients with multiple sclerosis (MS). A database analysis of all patients with MS who have ever been exposed to GA 20 mg/mL daily in clinical trials, including patients with up to 20 years of continuous treatment...
December 17, 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27986482/high-dose-rate-brachytherapy-for-the-treatment-of-lower-extremity-in-stent-restenosis
#17
Karen J Ho, Phillip M Devlin, Arin L Madenci, Marcus E Semel, Edwin C Gravereaux, Louis L Nguyen, Michael Belkin, Matthew T Menard
OBJECTIVE: Historically, edge stenosis and late thrombosis limited the effectiveness of adjunctive endovascular brachytherapy (EVBT) for in-stent restenosis (ISR) after percutaneous transluminal angioplasty (PTA) and stenting. We evaluated an updated protocol of PTA and EVBT for ISR among patients with lower extremity occlusive disease. METHODS: This is a retrospective, single-center review of patients treated with PTA and EVBT for ISR in the iliac and femoropopliteal segments between 2004 and 2012...
December 13, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27981492/sphincter-preserving-surgery-for-low-rectal-cancer-do-we-overshoot-the-mark
#18
Johannes Klose, Ignazio Tarantino, Yakup Kulu, Thomas Bruckner, Stefan Trefz, Thomas Schmidt, Martin Schneider, Thilo Hackert, Markus W Büchler, Alexis Ulrich
PURPOSE: Intersphincteric resection (ISR) is an alternative to abdominoperineal resection (APR) for a selected subset of patients with low rectal cancer, combining equivalent oncological outcome and sphincter preservation. However, functional results are heterogeneous and often imperfect. The aim of the present investigation was to determine the long-term functional results and quality of life after ISR. METHODS: One hundred forty-three consecutive patients who underwent surgery for low rectal cancer were analysed...
December 15, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27979748/association-of-transition-readiness-to-intentional-self-regulation-and-hopeful-future-expectations-in-youth-with-illness
#19
Laura C Hart, McLean Pollock, Sherika Hill, Gary Maslow
BACKGROUND: Little is known about how transition readiness relates to other developmental skills of adolescence in youth with chronic illness. Better understanding of how transition readiness relates to these other developmental skills could lead to a broader array of tools to improve transition readiness. Intentional self-regulation and hopeful future expectations are two developmental skills of adolescence that improve with participation in developmental programming, and thus are modifiable...
December 12, 2016: Academic Pediatrics
https://www.readbyqxmd.com/read/27974975/novel-use-of-an-orbital-atherectomy-device-for-in-stent-restenosis-lessons-learned
#20
K Shaikh, S Kelly, M Gedela, V Kumar, A Stys, T Stys
We present a case of a 67-year-old man with stage III chronic kidney disease, uncontrolled diabetes mellitus, coronary artery disease, and high surgical risk who presented with two episodes of acute coronary syndrome attributed to in-stent restenosis (ISR) associated with heavily calcified lesions. In this case, we were able to improve luminal patency with orbital atherectomy system (OAS); however, withdrawal of the device resulted in a device/stent interaction, causing failure of the device. Given limitations in current evidence and therapies, managing ISR can be a technical and cognitive challenge...
2016: Case Reports in Cardiology
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