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axial spondyloarthropathy

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https://www.readbyqxmd.com/read/29759124/the-seronegative-spondyloarthropathies
#1
REVIEW
Ayyappa S Duba, Stephanie D Mathew
The seronegative spondyloarthropathies are a group of five diseases characterized by inflammatory oligoarticular arthritis, enthesitis, and axial involvement. They have an increased incidence of the HLA-B27 gene. They are commonly associated with extra-articular features including involvement of the skin, eyes, and gastrointestinal tract. Early recognition and referral are key to limit disability, and comanagement with primary care and rheumatology offers the best outcomes.
June 2018: Primary Care
https://www.readbyqxmd.com/read/29702496/quantifying-the-genetic-risk-for-the-development-of-axial-spondyloarthropathy-could-this-become-a-diagnostic-tool
#2
Bryan P Wordsworth, Carla J Cohen, Matteo Vecellio
PURPOSE OF REVIEW: To assess the utility of recent genetic findings in ankylosing spondylitis (AS) and axial spondyloarthropathy (SpA) in relation to diagnostic testing, prognosis and responses to biologic treatment and the development of new therapies. RECENT FINDINGS: AS and other forms of SpA are polygenic with more than 100 genes contributing to disease susceptibility. The role of genes in determining the outcome of the disease and response to treatment is less clear...
April 26, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29678187/an-unexpected-cause-of-sacroiliitis-in-a-patient-with-gout-and-chronic-psoriasis-with-inflammatory-arthritis-a-case-report
#3
Safi Alqatari, Roberta Visevic, Nina Marshall, John Ryan, Grainne Murphy
BACKGROUND: Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis and reactive arthritis. Inflammatory back pain can be caused by many other conditions like infection and crystal deposition such as gout. In this case, it is difficult to specifically identify gout as a cause by ordinary imaging like magnetic resonance imaging (MRI) or ultrasound...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29609643/clinical-features-of-children-with-enthesitis-related-juvenile-idiopathic-arthritis-juvenile-spondyloarthritis-followed-in-a-french-tertiary-care-pediatric-rheumatology-centre
#4
Maxime Goirand, Sylvain Breton, Frédéric Chevallier, Ngoc-Phoi Duong, Florence Uettwiller, Isabelle Melki, Richard Mouy, Carine Wouters, Brigitte Bader-Meunier, Chantal Job-Deslandre, Pierre Quartier
BACKGROUND: Childhood-onset spondyloarthropathies usually start with enthesitis and peripheral arthritis. However, axial disease may develop afterward. Patients are most often classified, following revised (Edmonton 2011) ILAR criteria, as enthesitis-related arthritis, psoriatic arthritis, or unclassified juvenile idiopathic arthritis, particularly in cases of psoriasis in the patient or a first-degree relative. In adults, peripheral spondyloarthritis is classified by ASAS criteria. METHODS: We retrospectively studied patients with childhood-onset spondyloarthropathies followed for more than one year in our referral centre...
April 2, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29600211/unusual-presentation-of-spinal-gout-2-cases-report-and-literature-review
#5
Wesley Ng, Cheuk Hang Sin, Chong Hing Wong, Wing Fat Chiu, On Ming Chung
Introduction: Gouty spondyloarthropathy is generally believed to be uncommon. Together with the fact that it can mimic a variety of disease entities, it imposes significant diagnostic challenge in our clinical practice. In this article, we report two patients diagnosed with spinal gout, and both were initially suspected to have a pyogenic infection. Case Reports: The first patient, a 66-year-old man, was admitted for fever and a short history of bilateral upper limb weakness...
November 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29474666/adherence-to-recommendations-for-the-use-of-anti-tumour-necrosis-factor-and-its-impact-over-5-years-of-follow-up-in-axial-spondyloarthritis
#6
Clementina López-Medina, Maxime Dougados, Eduardo Collantes-Estévez, Anna Moltó
Objectives: To describe adherence to recommendations for TNFα blocker (TNFb) initiation and continuation in early axial Spondyloarthropathy (axSpA); and to evaluate the impact of adherence to these recommendations over 5 years of follow-up in the DEvenir des Spondyloarthrites Indifférenciées Récentes (DESIR) cohort. Methods: The first 5 years of follow-up of the DESIR early axSpA cohort were analysed. We evaluated adherence to Assessment of SpondyloArthritis International Society (ASAS) 2003/2006, 2016 and European Medicines Agency recommendations in axSpA patients for: TNFb initiation (patients were adherent if they either commenced TNFb therapy when they met the conditions for initiation or if they did not commence TNFb therapy when conditions were not met) and; TNFb continuation (either when they continued TNFb therapy when conditions to continue were met or when they discontinued when conditions were not met)...
May 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29409751/the-role-of-gut-microbiota-and-il-23-il-17-pathway-in-ankylosing-spondylitis-immunopathogenesis-new-insights-and-updates
#7
REVIEW
Farhad Babaie, Milad Hasankhani, Hamed Mohammadi, Elham Safarzadeh, Alireza Rezaiemanesh, Reza Salimi, Behzad Baradaran, Zohreh Babaloo
Ankylosing spondylitis (AS) is a type of arthritis that is referred to a group of chronic immune-mediated inflammatory diseases termed as seronegative spondyloarthropathies or spondyloarthritides. It typically affects the joints of the spinal and axial skeleton and exhibits common clinical features and genetic factors such as human leukocyte antigen class I allele HLA-B27, the Endoplasmic Reticulum Aminopeptidase 1 (ERAP1), and environmental factors such as microbial triggers. Although the precise etiopathogenic mechanisms that implicate the pathogenesis of AS have still remained to be clarified, the IL-23/IL-17 immune axis has been detected as an important factor in the immunopathogenesis of AS...
April 2018: Immunology Letters
https://www.readbyqxmd.com/read/29299630/stability-of-fatigue-pain-patient-global-assessment-and-the-bath-ankylosing-spondylitis-functional-index-basfi-in-spondyloarthropathy-patients-with-stable-disease-according-to-the-bath-ankylosing-spondylitis-disease-activity-index-basdai
#8
Ole Rintek Madsen
The study objective was to examine natural variation of the patient-reported outcome measures fatigue, pain, patient global assessment (PaGl) and the Bath Ankylosing Spondylitis Functional Index (BASFI) in patients with stable axial spondyloarthropathy (ax-SpA) defined on the basis of the Bath Spondylitis Ankylosing Disease Activity Index (BASDAI). 107 TNF-inhibitor treated stable ax-SpA patients were identified in the Danish rheumatology registry (DANBIO). According to the Assessment of SpondyloArthritis international Society (ASAS) response criteria, stable disease was defined as a change in BASDAI < 20 between two consecutive visits...
March 2018: Rheumatology International
https://www.readbyqxmd.com/read/29116386/clinical-and-ultrasonographic-enthesopathy-in-inflammatory-rheumatic-diseases-is-masei-or-only-calcaneal-enthesitis-sufficient
#9
Ekrem Süleyman, Kemal Nas, Halil Harman, Nedim Kaban
AIM: We aimed at investigating the ultrasonographic (US) and clinical prevalence of enthesopathy in patients with rheumatoid arthritis (RA), and axial spondyloarthropathy (SpA), as well as the correlation between this condition and disease activity, along with the quality of life. METHODS: Included in the study were 30 axial SpA, 21 patients with RA, and 25 healthy cases. Bath Anklylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Quality of Life (ASQoL), Disease activity index  28 (DAS28), and Health Assessment Questionnaire (HAQ) were used for clinical evaluation, and enthesal pain was evaluated by VAS, whereas enthesitis US evaluation was performed by using the MAdrid Sonographic Enthesitis Index (MASEI)...
November 7, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29075521/imaging-of-juvenile-spondyloarthritis-part-i-classifications-and-radiographs
#10
REVIEW
Iwona Sudoł-Szopińska, Piotr Gietka, Michał Znajdek, Genowefa Matuszewska, Magdalena Bogucevska, Ljubinka Damjanovska-Krstikj, Slavcho Ivanoski
Juvenile spondyloarthropathies are manifested mainly by symptoms of peripheral arthritis and enthesitis. By contrast with adults, children rarely present with sacroiliitis and spondylitis. Imaging and laboratory tests allow early diagnosis and treatment. Conventional radiographs visualize late inflammatory lesions and post-inflammatory complications. Early diagnosis is possible with the use of ultrasonography and magnetic resonance imaging. The first part of the article presents classifications of juvenile spondyloarthropathies and discusses their radiographic presentation...
September 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29018906/the-performance-of-classification-criteria-for-juvenile-spondyloarthropathies
#11
Amra Adrovic, Metin Sezen, Kenan Barut, Sezgin Sahin, Cengizhan Acikel, Erkan Demirkaya, Ozgur Kasapcopur
Juvenile spondyloarthropathies (JSpA) are a group of rheumatologic diseases with a disease onset before 16; characterized with enthesitis, lower extremity oligoarthritis, involvement of the axial skeleton and HLA B27 positivity. The diversity of classification criteria along with the phenotype heterogeneity makes the classification of JSpA challenging. The aim of our study was to evaluate the performance of the pre-determined and recently proposed classification criteria for JSpA. The study group consisted of 113 patients with JSpA and 150 patients with juvenile idiopathic arthritis (JIA)...
December 2017: Rheumatology International
https://www.readbyqxmd.com/read/28977661/managing-morbidity-and-treatment-related-toxicity-in-patients-with-ankylosing-spondylitis
#12
Martin Bergman, Amy Lundholm
AS is the prototypical member of the family of spondyloarthropathies, and is characterized by seronegativity, axial predominance and new bone formation, which underlie symptoms of inflammatory back pain, enthesopathy and extra-articular manifestations, including anterior uveitis, psoriasis and colitis. Patients with AS typically experience a wide variety of morbidities. These include both morbidities related to the disease itself-most prominently progressive, irreversible, structural damage to the axial or peripheral skeleton-and morbidities stemming from treatments for the disease, including toxicities from NSAID use, and increased risk of infections and immunogenicity concerns with biologics...
March 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/28966207/the-fascinating-paradox-of-osteoporosis-in-axial-spondyloarthropathy
#13
REVIEW
Gillian E Fitzgerald, Finbar D O'Shea
Low bone mineral density (BMD) is a recognized feature of axial spondyloarthropathy (axSpA). However, the osteoproliferation inherent in axSpA can make traditional dual-energy x-ray absorptiometry assessment inaccurate, particularly in structurally advanced disease. As a result, much about osteoporosis in axSpA is unknown. There is a wide variation in prevalence figures for low BMD in the literature. There is also no consensus regarding risk factors for developing low BMD in axSpA. It is accepted that there is an excess of vertebral fractures in patients with axSpA, but the role of low BMD in contributing to this risk is virtually unknown...
December 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28920498/an-update-on-biomarker-discovery-and-use-in-axial-spondyloarthritis
#14
Walter P Maksymowych
Evaluation of diagnosis, disease activity, and risk for joint damage all represent important unmet clinical needs in the management of axial spondyloarthritis that have been explored using biomarkers. Areas covered: This review used the search terms biomarkers, ankylosing spondylitis, spondyloarthritis, spondyloarthropathy, pathogenesis, genetics, diagnostic tools, prognosis, to explore advances in biomarker development relevant to unmet clinical needs. Expert commentary: Despite major advances in the identification of genetic risk markers, HLA-B*27 remains the only marker with clinical utility for diagnostic purposes...
November 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28749173/mri-assessment-of-sacroiliitis-for-the-diagnosis-of-axial-spondyloarthropathy-comparison-of-fat-saturated-t2-stir-and-contrast-enhanced-sequences
#15
COMPARATIVE STUDY
Siyoun Sung, Hyun Su Kim, Jong Won Kwon
OBJECTIVE: To evaluate whether there are significant differences between contrast-enhanced fat-saturated T1 weighted imaging and non-enhanced fat-suppression imaging for diagnosing sacroiliitis in patients with inflammatory back pain. METHODS: 92 patients, consisting of 46 males and 46 females (mean age: 34 years; range: 15-63 years), who met at least 4 out of 5 Assessment in SpondyloArthritis international Society criteria for inflammatory low back pain were enrolled in this study...
October 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28551170/switching-tumor-necrosis-factor-inhibitors-in-the-treatment-of-axial-spondyloarthritis
#16
REVIEW
Atul Deodhar, David Yu
OBJECTIVE: To assess the impact of switching tumor necrosis factor (TNF)-alpha inhibitors on patients with axial spondyloarthritis (axSpA). METHODS: PubMed literature searches were conducted using combinations of search terms including ankylosing spondylitis, spondyloarthropathy, spondyloarthritis, switch/switching, drug survival, and TNF/tumor necrosis factor to identify published articles with data on outcomes related to switching biologic therapies in patients with axSpA...
December 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28511725/the-performance-of-different-classification-criteria-sets-for-spondyloarthritis-in-the-worldwide-asas-comospa-study
#17
MULTICENTER STUDY
Pauline Bakker, Anna Moltó, Adrien Etcheto, Filip Van den Bosch, Robert Landewé, Floris van Gaalen, Maxime Dougados, Désirée van der Heijde
BACKGROUND: In this study, we sought to compare the performance of spondyloarthritis (SpA) classification criteria sets in an international SpA cohort with patients included from five continents around the world. METHODS: Data from the (ASAS) COMOrbidities in SPondyloArthritis (ASAS-COMOSPA) study were used. ASAS-COMOSPA is a multinational, cross-sectional study with consecutive patients diagnosed with SpA by rheumatologists worldwide. Patients were classified according to the European Spondyloarthropathy Study Group (ESSG), modified European Spondyloarthropathy Study Group (mESSG), Amor, modified Amor, Assessment of SpondyloArthritis international Society (ASAS) axial Spondyloarthritis (axSpA), ASAS peripheral spondyloarthritis (pSpA) and ClASsification criteria for Psoriatic Arthritis (CASPAR) criteria...
May 16, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28488046/features-of-the-achilles-tendon-paratenon-and-enthesis-in-inflammatory-rheumatic-diseases-a%C3%A2-clinical-and-ultrasonographic-study
#18
H Harman, E Süleyman
AIM: We analyzed the ultrasonographic (US) features of the Achilles tendon (AT), paratenon (AP), and enthesis in patients with axial spondyloarthropathies (SpA) and rheumatoid arthritis (RA), and compared these to healthy subjects. Relationships between these findings and clinical and functional parameters were identified. METHODS: The study included 40 axial SpA and 27 RA patients, as well as 30 healthy subjects. Clinical evaluation relied on the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), AS Quality of Life Questionnaire (ASQoL), Disease Activity Score 28 (DAS28), and Health Assessment Questionnaire (HAQ), as well as on a visual analog scale (VAS) for entheseal pain and the Madrid Sonographic Enthesistis Index (MASEI)...
May 9, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28473095/acr-appropriateness-criteria%C3%A2-chronic-back%C3%A2-pain%C3%A2-suspected-sacroiliitis-spondyloarthropathy
#19
Stephanie A Bernard, Mark J Kransdorf, Francesca D Beaman, Ronald S Adler, Behrang Amini, Marc Appel, Erin Arnold, R Carter Cassidy, Bennett S Greenspan, Kenneth S Lee, Michael J Tuite, Eric A Walker, Robert J Ward, Daniel E Wessell, Barbara N Weissman
Inflammatory sacroiliitis or the seronegative axial spondyloarthropathies often presents as back pain or sacroiliac joint pain of more than 3-month duration with inflammatory symptoms and typically in patients younger than 45 years of age. Imaging plays an important role in diagnosis and disease monitoring. This article addresses the appropriate sequence of initial imaging for evaluation of a suspected spondyloarthropathy, the imaging follow-up of treatment response and the special considerations for imaging of trauma in patients with ankylosis of the spine...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28438449/ankylosing-spondylitis-increases-perioperative-and-postoperative-complications-after-total-hip-arthroplasty
#20
Daniel J Blizzard, Colin T Penrose, Charles Z Sheets, Thorsten M Seyler, Michael P Bolognesi, Christopher R Brown
BACKGROUND: Ankylosing spondylitis (AS) is a chronic autoimmune spondyloarthropathy that primarily affects the axial spine and hips. Progressive disease leads to pronounced spinal kyphosis, positive sagittal balance, and altered biomechanics. The purpose of this study is to determine the complication profile of patients with AS undergoing total hip arthroplasty (THA). METHODS: The Medicare sample was searched from 2005 to 2012 yielding 1006 patients with AS who subsequently underwent THA...
March 27, 2017: Journal of Arthroplasty
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