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axial spondyloarthropathy

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https://www.readbyqxmd.com/read/27749215/burden-of-illness-associated-with-non-radiographic-axial-spondyloarthritis-a-multiperspective-european-cross-sectional-observational-study
#1
Joachim Sieper, Tim Holbrook, Christopher M Black, Robert Wood, Xiaohan Hu, Sumesh Kachroo
OBJECTIVES: To assess the impact of non-radiographic axial spondyloarthritis (nr-axSpA) on patients and society based on real-world evidence from the Adelphi nr-axSpA Disease Specific Programme, a cross-sectional survey of rheumatologists and their patients in Germany, France, Spain, Italy and the UK. METHODS: Physicians completed patient record forms for the next two patients consulting with nr-axSpA (diagnosis at the physician's judgement); patients were invited to complete a patient self-completion form...
August 31, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27649417/high-prevalence-of-back-pain-and-axial-spondyloarthropathy-in-patients-with-hidradenitis-suppurativa
#2
Sylke Schneider-Burrus, Ellen Witte-Haendel, Demetrios Christou, Benedetta Rigoni, Robert Sabat, Gerd Diederichs
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease, causing fistulating sinuses in the intertriginous skin of axillary, genitofemoral and perianal sites. OBJECTIVE: As other chronic inflammatory diseases, e.g. psoriasis, are frequently associated with spondyloarthropathies (SpA), the goal of this study was to quantify the prevalence of back pain and SpA in HS patients. METHODS: A prospective questionnaire survey in 100 HS patients and a retrospective evaluation of pelvic magnetic resonance imaging (MRI) scans in 46 HS patients were conducted...
September 21, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27636905/autoimmune-arthritides-rheumatoid-arthritis-psoriatic-arthritis-or-peripheral-spondyloarthropathy-following-lyme-disease
#3
Sheila L Arvikar, Jameson T Crowley, Katherine B Sulka, Allen C Steere
OBJECTIVE: To describe systemic autoimmune joint diseases following Lyme disease and to compare their clinical features with Lyme arthritis. METHODS: Records of all adult patients referred to our Lyme arthritis clinic over a 13-year period in whom we diagnosed a systemic autoimmune joint disease following Lyme disease were reviewed. For comparison, records of patients enrolled in our Lyme arthritis (LA) cohort over the most recent 2-year period were analyzed. IgG antibodies to Borrelia burgdorferi and to 3 Lyme disease-associated autoantigens were measured...
September 16, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27450198/impact-of-lumbar-syndesmophyte-on-bone-health-as-assessed-by-bone-density-bmd-and-bone-texture-tbs-in-men-with-axial-spondyloarthritis
#4
Laura Wildberger, Vladimira Boyadzhieva, Didier Hans, Nikolay Stoilov, Rasho Rashkov, Bérengère Aubry-Rozier
INTRODUCTION: Patients with spondyloarthritis (SpA) have an elevated incidence of osteoporosis and are at increased risk of pathological vertebral fracture. Evaluation of bone density by dual energy X-ray absorptiometry (DXA) has its limits in fracture prediction, already known in this population. One hypothesis is that the presence of lumbar syndesmophyte could overestimate the spine bone mineral density (BMD). Trabecular bone score (TBS) is a new texture measurement correlated with bone microarchitecture...
July 20, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27425039/new-insights-toward-the-pathogenesis-of-ankylosing-spondylitis-genetic-variations-and-epigenetic-modifications
#5
Mahdi Mahmoudi, Saeed Aslani, Mohammad Hossein Nicknam, Jafar Karami, Ahmad Reza Jamshidi
Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, characterized by typically an axial arthritis. AS is the prototype of a group of disorders called spondyloarthropathies, which is believed to have common clinical manifestations and genetic predisposition. To date, the exact etiology of AS remains unclear. Over the past few years, however, the role of genetic susceptibility and epigenetic modifications caused through environmental factors have been extensively surveyed with respect to the pathogenesis of AS, resulted in important advances...
July 18, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27402112/juvenile-spondyloarthropathies
#6
REVIEW
Amra Adrovic, Kenan Barut, Sezgin Sahin, Ozgur Kasapcopur
Juvenile spondyloarthropathies represent a clinical entity separate from the adult disease. Initial clinical signs of juvenile spondyloarthropathies often include lower extremity arthritis and enthesopathy, without axial involvement at the disease onset. Asymmetrical oligoarthritis of lower extremities is typically seen in this type of arthritis. Enthesopathy, which is the hallmark of the disease, is most commonly seen in the Achilles tendon, being manifested by heel pain. Anterior uveitis and HLA-B27 positivity are seen in a proportion of cases...
August 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/27390225/prevalence-of-axial-spondyloarthropathy-among-patients-suffering-from-fibromyalgia-an-mri-study-with-application-of-the-asas-classification-criteria
#7
Jacob N Ablin, Iris Eshed, Mark Berman, Valerie Aloush, Irena Wigler, Dan Caspi, Maria Likhter, Jonathan Wollman, Daphna Paran, Marina Anouk, Ori Elkayam
Objective To evaluate the prevalence of sacroiliitis, the radiographic hallmark of inflammatory spondyloarthropathy, among patients diagnosed with the fibromyalgia syndrome, using the current ASAS criteria and MR imaging. Methods Patients suffering from FMS (ACR 1990 criteria) were interviewed regarding presence of SpA features and underwent HLA-B27 testing, CRP measurement and MRI examinations of the sacro-iliac joints. FMS severity was assessed by the FIQ and SF-36 questionnaires. SpA severity was assessed by the BASDAI...
July 7, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27385374/efficacy-safety-and-cost-per-responder-of-biologics-in-the-treatment-of-non-radiographic-axial-spondyloarthritis
#8
Ignazio Olivieri, Caterina Fanizza, Michele Gilio, Roberto Ravasio
Anti-tumour necrosis factor (TNF) agents are recommended as second-line therapy for patients with axial spondyloarthropathies. This analysis reviewed data on studies investigating the efficacy and tolerability of anti-TNF agents in patients with non-radiographic axial spondyloarthritis (nr-axSpA) who had failed first-line non-steroidal anti-inflammatory (NSAID) treatment. Efficacy data from RCTs were used to calculate the number needed to treat (NNT) for individual anti-TNFs and then the cost per responder was determined to provide an indication of the value of each therapy...
July 4, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27305852/spondyloarthropathies-identifying-axial-spa-in-young-adults-with-chronic-back-pain
#9
Martin Rudwaleit
No abstract text is available yet for this article.
July 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27149917/kinases-inhibitors-and-small-molecules-a-new-treatment-tool-for-axial-spondyloarthropathy
#10
EDITORIAL
Daniel Wendling, Clément Prati
No abstract text is available yet for this article.
October 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27089188/whole-body-mr-imaging-musculoskeletal-applications
#11
REVIEW
Frédéric E Lecouvet
Whole-body magnetic resonance (MR) imaging has been evaluated in many oncologic and rheumatologic indications and is emerging as a powerful tool for early diagnosis, quantification of disease extent, therapeutic decision making, and treatment monitoring. This development of whole-body MR imaging comes at a time marked by the rapid development of modern, powerful, but expensive and potentially toxic treatments. In oncology, the feasibility and diagnostic performance of diffusion-weighted imaging (DWI) applied to the whole body largely contribute to the effectiveness of whole-body MR imaging...
May 2016: Radiology
https://www.readbyqxmd.com/read/26968522/biologic-agents-in-juvenile-spondyloarthropathies
#12
REVIEW
María Martha Katsicas, Ricardo Russo
The juvenile spondyloarthropathies (JSpA) are a group of related rheumatic diseases characterized by involvement of peripheral large joints, axial joints, and entheses (enthesitis) that begin in the early years of life (prior to 16(th) birthday).The nomenclature and concept of spondyloarthropathies has changed during the last few decades. Although there is not any specific classification of JSpA, diseases under the spondyloarthropathy nomenclature umbrella in the younger patients include: the seronegative enthesitis and arthropathy (SEA) syndrome, juvenile ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated arthritis...
March 12, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/26968111/trafficking-of-antigens-from-gut-to-sacroiliac-joints-and-spine-in-reactive-arthritis-and-spondyloarthropathies-mainly-through-lymphatics
#13
Jean-Marie Berthelot, Pascal Claudepierre
Bacterial trafficking from gut to mesenteric lymph nodes is physiologic only for a few commensal species, like Alcaligenes which produces antimicrobial-substances inhibiting growth of pathogenic bacteria. In reactive arthritis, some living bacteria transiently manage to travel from gut to joints/enthesis within dendritic cells and/or macrophages. Migration of dead or dormant bacteria outside the gut in spondyloarthropathies, including those associated with Crohn's disease, can occur either through blood or lymphatics...
October 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/26875714/-presence-of-subclinical-inflammation-in-axial-spondyloarthropathy-patients-in-clinical-remission
#14
Ying Wu, Shengqian Xu, Shan Qi, Weng Liu, Jing Cai, Jianhua Xu
OBJECTIVE: To investigate the incidence of bone marrow edema in sacroiliac joint under examination of magnetic resonance imaging (MRI) in patients with axial spondyloarthropathy (SpA) in remission. METHODS: A total of 87 patients with axial SpA were recruited. Disease activity was assessed by calculation of BASDAI and ASDAScrp scores. All the SpA patients completed MRI scan of sacroiliac joint and bone marrow edema in sacroiliac joint was quantized by SPARCC scoring standard...
February 2, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26869521/spondylodiscitis
#15
P Márquez Sánchez
Spondylodiscitis is an infection of the spine that has been known since ancient times. Its incidence is rising, due to the increases in life expectancy and debilitating conditions. Its age distribution is bimodal, affecting persons younger than 20 years of age or persons aged 50-70 years. According to its origin, it is classified as pyogenic, granulomatous or parasitic, though the first form is the most common, usually caused by Staphylococcus aureus or Escherichia coli. The clinical presentation is insidious, resulting in a delayed diagnosis, particularly in tuberculous spondylodiscitis...
April 2016: Radiología
https://www.readbyqxmd.com/read/26832154/evaluation-of-treatments-for-sacroiliitis-in-spondyloarthropathy-using-the-spondyloarthritis-research-consortium-canada-scoring-system
#16
Yang Cui, Jinping Zheng, Xiao Zhang, Hui Zeng, Riqiang Luo
BACKGROUND: In this study, the Spondyloarthritis Research Consortium Canada (SPARCC) scoring method was used to compare treatment methods in patients with axial spondyloarthritis (SpA), a form of sacroiliitis. MRI abnormalities in bone marrow edema (BME) were compared before and after treatment in order to compare the efficacy of anti-TNF-α and DMARD, alone or in combination, as treatments for sacroiliitis. METHODS: Fifty-six Chinese patients with axial SpA (mean age 22...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26799059/comparison-of-fetuin-a-and-transforming-growth-factor-beta-1-levels-in-patients-with-spondyloarthropathies-and-rheumatoid-arthritis
#17
Halil Harman, İbrahim Tekeoğlu, Gönül Gürol, Mustafa Serdar Sağ, Engin Karakeçe, İhsan Hakkı Çİftçİ, Ayhan Kamanlı, Kemal Nas
AIM: We investigated the serum transforming growth factor beta 1 (TGFβ1) and fetuin-A levels, and determined the relationships between these biomarkers and disease activity, mobility and radiologic progression in patients with spondyloarthropathy (SpA) and rheumatoid arthritis (RA). METHOD: The study included 55 patients with SpA and 38 patients with RA, together with 28 healthy subjects. In AS patients, we assessed disease activity using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), functional ability using the Bath Ankylosing Spondylitis Functional Index (BASFI), and mobility using the Bath Ankylosing Spondylitis Metrology Index (BASMI), radiologic progression using the Bath Ankylosing Spondylitis Radiology Index (BASRI)...
January 22, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/26781782/evaluation-of-acute-and-chronic-mri-features-of-sacroiliitis-in-asymptomatic-primary-hyperparathyroid-patients
#18
Mehmet Engin Tezcan, Sule Temizkan, Safiye Tokgoz Ozal, Deniz Gul, Kadriye Aydin, Aysenur Ozderya, Mehmet Sargin
Asymptomatic primary hyperparathyroidism (PHPT) is characterized with autonomous overproduction of parathyroid hormone without signs or symptoms associated with hyperparathyroidism. Before symptoms become obvious, PHPT may affect structures like sacroiliac joints, which consist of bone. So, in the asymptomatic PHPT patients, structural and inflammatory changes in sacroiliac joints may lead to confusion during diagnosis workup of axial spondyloarthropathy. In this study, we evaluated active and chronic sacroiliac magnetic resonance imaging (MRI) changes relevant to sacroiliitis in the patients with asymptomatic PHPT and interpreted bone marrow edema within the scope of Assessment of SpondyloArthritis International Society-Outcome Measures in Rheumatology Clinical Trials (ASAS-OMERACT) criteria...
January 19, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/26690935/the-prevalence-of-axial-spondyloarthritis-in-the-uk-a-cross-sectional-cohort-study
#19
Louise Hamilton, Alex Macgregor, Andoni Toms, Victoria Warmington, Edward Pinch, Karl Gaffney
BACKGROUND: Accurate prevalence data are important when interpreting diagnostic tests and planning for the health needs of a population, yet no such data exist for axial spondyloarthritis (axSpA) in the UK. In this cross-sectional cohort study we aimed to estimate the prevalence of axSpA in a UK primary care population. METHODS: A validated self-completed questionnaire was used to screen primary care patients with low back pain for inflammatory back pain (IBP). Patients with a verifiable pre-existing diagnosis of axSpA were included as positive cases...
December 21, 2015: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/26560062/analysis-of-hla-b15-and-hla-b27-in-spondyloarthritis-with-peripheral-and-axial-clinical-patterns
#20
John Londono, Ana Maria Santos, Paola Peña, Enrique Calvo, Luis R Espinosa, John D Reveille, Gilberto Vargas-Alarcon, Carlos A Jaramillo, Rafael Valle-Oñate, Mabel Avila, Consuelo Romero, Juan F Medina
OBJECTIVE: Human leucocyte antigen (HLA) B27 and HLA-B15 are associated with spondyloarthritis (SpA). Recent Assessment of SpondyloArthritis international Society (ASAS) criteria emphasise a distinction between SpA with axial and peripheral patterns. We analysed whether HLA-A, HLA-B and HLA-DRB1 alleles could associate with these patterns. METHODS: We studied 100 healthy individuals and 178 patients with SpA according to European Spondyloarthropathy Study Group (ESSG) criteria...
2015: BMJ Open
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