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cardiovascular, myocardial, angioplasty, coronary

Nuno Cortez-Dias, Marina C Costa, Pedro Carrilho-Ferreira, Doroteia Silva, Cláudia Jorge, Carina Calisto, Teresa Pessoa, Susana Robalo Martins, João Carvalho de Sousa, Pedro Canas da Silva, Manuela Fiúza, António Nunes Diogo, Fausto J Pinto, Francisco J Enguita
BACKGROUND: MicroRNAs (miRNAs) are key players in cardiovascular development and disease. However, not only miRNAs of a cardiac origin have a critical role in heart function. Recent studies have demonstrated that miR-122-5p, a hepatic miRNA, increases in the bloodstream during ischemic cardiogenic shock and it is upregulated in the infarcted myocardium. The aim of the present study was to determine the potential of circulating miR-122-5p as a biomarker for early prognostic stratification of ST-segment elevation acute myocardial infarction (STEMI) patients...
September 23, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Eric J Shiroma, Nancy R Cook, JoAnn E Manson, M V Moorthy, Julie E Buring, Eric B Rimm, I-Min Lee
PURPOSE: To examine the association of strength training with incident type 2 diabetes and cardiovascular disease risk. METHODS: We followed 35 754 healthy women (mean age, 62.6 years, range 47.0 - 97.8) from the Women's Health Study, who responded to a health questionnaire that included physical activity questions in 2000; assessing health outcomes through annual health questionnaire through 2014 (average (SD) follow-up = 10.7 (3.7) years). Incident type 2 diabetes (N cases = 2120) and cardiovascular disease (N cases = 1742) were confirmed on medical record review...
August 30, 2016: Medicine and Science in Sports and Exercise
G S Stergiou, A Margetaki, N Boubouchairopoulou, A Mastrokostas, A Vantarakis, G Chlouverakis, G Rachiotis, G Trypsianis, P Voulgari, I Alamanos, A Karakosta, G Touloumi
OBJECTIVE: To date no nationwide epidemiological study of cardiovascular disease has been performed in the general population in Greece. This study evaluated the prevalence of coronary heart disease and stroke in individuals with hypertension in a randomly selected general population sample of adults in Greece. DESIGN AND METHOD: The EMENO survey (National Morbidity and Risk Factors Survey) supported by the European Social Fund and national funds, is currently performed in Greece, aiming to include 6,000 adults aged > = 18 years...
September 2016: Journal of Hypertension
Wei-Chieh Lee, Yen-Nan Fang, Chih-Yuan Fang, Chien-Jen Chen, Cheng-Hsu Yang, Hon-Kan Yip, Chi-Ling Hang, Chiung-Jen Wu, Hsiu-Yu Fang
BACKGROUND: Drug-eluting balloons (DEBs) have emerged as a potential alternative to current treatments of instent restenosis (ISR). The study aims to investigate the clinical outcomes of a DEB angioplasty to treat bare-metal stent (BMS) ISR and drug-eluting stent (DES) ISR at 1-year clinical follow-up period. METHODS: Between November 2011 and December 2014, 312 patients were diagnosed with coronary artery ISR at our hospital. A total of 426 coronary ISR lesions were treated with DEBs...
October 2016: Journal of Interventional Cardiology
Mark D Danese, Michelle Gleeson, Lucie Kutikova, Robert I Griffiths, Ali Azough, Kamlesh Khunti, Sreenivasa Rao Kondapally Seshasai, Kausik K Ray
OBJECTIVES: To characterise the costs to the UK National Health Service of cardiovascular (CV) events among individuals receiving lipid-modifying therapy. DESIGN: Retrospective cohort study using Clinical Practice Research Datalink records from 2006 to 2012 to identify individuals with their first and second CV-related hospitalisations (first event and second event cohorts). Within-person differences were used to estimate CV-related outcomes. SETTING: Patients in the UK who had their first CV event between January 2006 and March 2012...
2016: BMJ Open
Leszek Wrotniak, Anna Kablak-Ziembicka, Izabela Karch, Piotr Pieniazek, Agnieszka Rosławiecka, Szymon Mleczko, Lukasz Tekieli, Krzysztof Zmudka, Tadeusz Przewlocki
OBJECTIVES: To identify independent predictors of cardiovascular events among patients with subclavian artery stenosis. METHODS: Two hundred eighteen consecutive patients with subclavian artery stenosis referred to angioplasty were examined for coexistent coronary, renal, or lower extremity artery stenosis of 50% or greater. Initial carotid intima-media thickness and internal carotid artery (ICA) stenosis were assessed. Intima-media thickness was reassessed in 108 randomly chosen patients to evaluate the change over time...
September 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Leonida Compostella, Sonia Lorenzi, Nicola Russo, Tiziana Setzu, Caterina Compostella, Elia Vettore, Giambattista Isabella, Giuseppe Tarantini, Sabino Iliceto, Fabio Bellotto
The presence of major depressive symptoms is usually considered a negative long-term prognostic factor after an acute myocardial infarction (AMI); however, most of the supporting research was conducted before the era of immediate reperfusion by percutaneous coronary intervention. The aims of this study are to evaluate if depression still retains long-term prognostic significance in our era of immediate coronary reperfusion, and to study possible correlations with clinical parameters of physical performance...
July 12, 2016: Internal and Emergency Medicine
Tiantian Li, Yangnan Ding, Jiang Wu, Yang Shen, Xiaoheng Liu
Coronary heart disease is a kind of heart disease that is caused by atherosclerosis. The lipid deposition in the vessel wall results in occlusion of coronary artery and stenosis, which could induce myocardial ischemia and oxygen deficiency. Intervention therapies like percutaneous coronary intervention (PCI) and coronary stent improve myocardial perfusion using catheter angioplasty to reduce stenosis and occlusion of coronary artery lumen. Accordingly, intervention therapies are widely applied in clinic to treat ischemic cardiovascular disease, arterial intima hyperplasia and other heart diseases, which could save the patients' life rapidly and effectively...
February 2016: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
Meng-Han Chou, Ying-Chieh Chen, Kwei-Shuai Hwang, Mu-Hsien Yu, Her-Young Su
OBJECTIVE: To present a rare case of life-threatening postpartum hemorrhage due to uterine atony complicated by acute myocardial infarction and ischemic hepatitis. CASE REPORT: A 37-year-old parturient, gravida 1 para 0, presented with symptoms and signs of shock due to postpartum hemorrhage after delivery. Ischemic hepatitis, pulmonary edema, and adult respiratory distress syndrome developed the following morning. On the 7(th) postpartum day, she developed chest pain and was subsequently diagnosed with acute inferior myocardial infarction based on serial changes on the electrocardiogram (ECG) and myocardial enzymes...
June 2016: Taiwanese Journal of Obstetrics & Gynecology
Roberto Caporale, Giovanna Geraci, Michele Massimo Gulizia, Mauro Borzi, Furio Colivicchi, Alberto Menozzi, Giuseppe Musumeci, Marino Scherillo, Antonietta Ledda, Giuseppe Tarantini, Piersilvio Gerometta, Giancarlo Casolo, Dario Formigli, Francesco Romeo, Roberto Di Bartolomeo
The wide availability of drugs effective in reducing cardiovascular events and the use of myocardial revascularization have greatly improved the prognosis of patients with coronary artery disease. However, the combination of antithrombotic drugs to be administered before the exact knowledge of the coronary anatomy and before the consequent therapeutic strategy can, on one hand, allow to anticipate an optimal treatment but, on the other hand, may expose the patient to a bleeding risk not always necessary. In patients with ST-elevation acute coronary syndrome with an indication to primary angioplasty, the administration of unfractionated heparin and aspirin is considered the pre-procedural standard treatment...
June 2016: Giornale Italiano di Cardiologia
L Socias, G Frontera, C Rubert, A Carrillo, V Peral, A Rodriguez, C Royo, M Ferreruela, J Torres, R Elosua, A Bethencourt, M Fiol
OBJECTIVE: To investigate the differences in mortality at 28 days and other prognostic variables in 2 periods: IBERICA-Mallorca (1996-1998) and Infarction Code of the Balearic Islands (IC-IB) (2008-2010). DESIGN: Two observational prospective cohorts. SETTING: Hospital Universitario Son Dureta, 1996-1998 and 2008-2010. PATIENTS: Acute coronary syndrome with ST elevation of≤24h of anterior and inferior site. MAIN VARIABLES OF INTEREST: Age, sex, cardiovascular risk factors, site of AMI, time delays, reperfusion therapy with fibrinolysis and primary angioplasty, administration of acetylsalicylic acid, beta blockers and angiotensin converting enzyme inhibitors...
June 10, 2016: Medicina Intensiva
Robert Wolk, Marnie Bertolet, Prachi Singh, Maria M Brooks, Richard E Pratley, Robert L Frye, Arshag D Mooradian, Martin K Rutter, Andrew D Calvin, Bernard R Chaitman, Virend K Somers
OBJECTIVE: To evaluate the cardiovascular (CV) prognostic value of adipokines in a large prospective cohort of patients participating in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial. PATIENTS AND METHODS: The effects of the adipokine levels at baseline and change from baseline on the composite outcome (CV death, myocardial infarction, and stroke) were analyzed using unadjusted and fully adjusted Cox models in 2330 patients with type 2 diabetes and coronary artery disease who had participated in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial (from January 1, 2001, through December 1, 2008)...
July 2016: Mayo Clinic Proceedings
Haley R Gittleman, Alona Merkulova, Omar Alhalabi, Evi X Stavrou, Martina L Veigl, Jill S Barnholtz-Sloan, Alvin H Schmaier
Plasma kallikrein formed from prekallikrein (PK) produces bradykinin from kininogens and activates factor XII. Plasma PK is activated by factors αXIIa, βXIIa, or prolylcarboxypeptidase (PRCP). A cross-sectional investigation determined if there is an association of PRCP and KLKB1 polymorphisms with cardiovascular disease (CVD). DNA was obtained from 2243 individuals from the Prevention of Events with Angiotensin Converting Enzyme trial. Two PRCP SNPs, rs7104980 and rs2298668, and two KLKB1 SNPs, rs3733402 and rs3087505, were genotyped...
2016: Frontiers in Medicine
W M Wilson, S J Walsh, A T Yan, C G Hanratty, A J Bagnall, M Egred, E Smith, K G Oldroyd, M McEntegart, J Irving, J Strange, H Douglas, J C Spratt
OBJECTIVES: Treatment options for coronary chronic total occlusions (CTO) are limited, with low historical success rates from percutaneous coronary intervention (PCI). We report procedural outcomes of CTO PCI from 7 centres with dedicated CTO operators trained in hybrid approaches comprising antegrade/retrograde wire escalation (AWE/RWE) and dissection re-entry (ADR/RDR) techniques. METHODS: Clinical and procedural data were collected from consecutive unselected patients with CTO between 2012 and 2014...
September 15, 2016: Heart: Official Journal of the British Cardiac Society
Patrick Goldstein, Niccolò Grieco, Hüseyin Ince, Nicolas Danchin, Yvonne Ramos, Jochen Goedicke, Peter Clemmensen
AIM: MULTIPRAC was designed to provide insights into the use and outcomes associated with prehospital initiation of antiplatelet therapy with either prasugrel or clopidogrel in the context of primary percutaneous coronary intervention. After a previous report on efficacy and safety outcomes during hospitalization, we report here the 1-year follow-up data, including cardiovascular (CV) mortality. METHODS AND RESULTS: MULTIPRAC is a multinational, prospective registry of patients with ST-elevation myocardial infarction (STEMI) from 25 hospitals in nine countries, all of which had an established practice of prehospital start of dual antiplatelet therapy in place...
2016: Vascular Health and Risk Management
Per Tornvall, Olov Collste, Ewa Ehrenborg, Hans Järnbert-Petterson
BACKGROUND: Takotsubo stress cardiomyopathy (TSC) is a syndrome characterized by transient myocardial dysfunction with unknown etiology. Although recent studies have suggested that the syndrome is associated with comorbidity and has a dismal prognosis, there is a lack of comprehensive data describing the epidemiology and prognosis of TSC. OBJECTIVES: This study compared risk markers and mortality in patients with TSC with that of individuals with or without coronary artery disease (CAD)...
April 26, 2016: Journal of the American College of Cardiology
Ngan N Lam, S Joseph Kim, Gregory A Knoll, Eric McArthur, Krista L Lentine, Kyla L Naylor, Alvin H Li, Salimah Z Shariff, Christine M Ribic, Amit X Garg
BACKGROUND: Cardiovascular death remains the leading cause of mortality in kidney transplant recipients. Cardiovascular events are associated with significant morbidity. However, current trends in cardiovascular events after kidney transplantation are poorly understood. METHODS: We conducted a retrospective study using health care databases in Ontario, Canada, to determine whether the incidence of cardiovascular events after kidney transplantation has changed from 1994 to 2009...
March 16, 2016: Transplantation
Alberto Cordero, Ramón López-Palop, Pilar Carrillo, Araceli Frutos, Sandra Miralles, Clara Gunturiz, María García-Carrilero, Vicente Bertomeu-Martínez
INTRODUCTION AND OBJECTIVES: Emergency care systems have been created to improve treatment and revascularization in myocardial infarction but they may also improve the management of all patients with acute coronary syndrome. METHODS: A comparative study of all patients admitted with acute coronary syndrome before and after implementation of an infarction protocol. RESULTS: The study included 1210 patients. While the mean age was the same in both periods, the patient group admitted after implementation of the protocol had a lower prevalence of diabetes mellitus and hypertension but more active smokers and higher GRACE scores...
August 2016: Revista Española de Cardiología
I-Chih Chen, Cheng-Han Lee, Ting-Hsing Chao, Wei-Kung Tseng, Tsung-Hsien Lin, Wen-Jung Chung, Jen-Kwan Li, Hsuan-Li Huang, Ping-Yen Liu, Ting-Kuang Chao, Chuin-Yuan Chu, Chih-Chan Lin, Po-Chao Hsu, Wen-Huang Lee, Po-Tseng Lee, Yi-Heng Li, Shih-Ya Tseng, Liang-Miin Tsai, Juey-Jen Hwang
BACKGROUND: The prevalence of significant obstructive coronary artery disease with complex lesions is high in patients who have low extremity artery disease (LEAD). However, intermediate- or long-term cardiovascular prognosis of LEAD patients undergoing percutaneous transluminal angioplasty (PTA) remains poor. Accordingly, prophylactic coronary revascularization may modify short- and long-term cardiovascular outcomes of LEAD patients receiving PTA. Because myocardial ischemic symptoms are often masked in LEAD and the accuracy of non-invasive stress tests is usually limited, a high-quality randomized controlled trial aimed at the investigation of the prognostic role of coronary evaluation strategies before PTA is warranted...
2016: Trials
Giuseppe Vassalli, Catherine Klersy, Stefano De Servi, Soeren Galatius, Paul Erne, Franz Eberli, Hans Rickli, Burkhard Hornig, Osmund Bertel, Piero Bonetti, Tiziano Moccetti, Christoph Kaiser, Matthias Pfisterer, Giovanni Pedrazzini
BACKGROUND: The randomized BASKET-PROVE study showed no significant differences between sirolimus-eluting stents (SES), everolimus-eluting stents (EES), and bare-metal stents (BMS) with respect to the primary end point, rates of death from cardiac causes, or myocardial infarction (MI) at 2 years of follow-up, in patients requiring stenting of a large coronary artery. Clinical risk factors may affect clinical outcomes after percutaneous coronary interventions. We present a retrospective analysis of the BASKET-PROVE data addressing the question as to whether the optimal type of stent can be predicted based on a cumulative clinical risk score...
March 2016: American Heart Journal
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