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https://www.readbyqxmd.com/read/28821511/development-and-validation-of-clinical-prediction-models-for-mortality-functional-outcome-and-cognitive-impairment-after-stroke-a-study-protocol
#1
Marion Fahey, Anthony Rudd, Yannick Béjot, Charles Wolfe, Abdel Douiri
INTRODUCTION: Stroke is a leading cause of adult disability and death worldwide. The neurological impairments associated with stroke prevent patients from performing basic daily activities and have enormous impact on families and caregivers. Practical and accurate tools to assist in predicting outcome after stroke at patient level can provide significant aid for patient management. Furthermore, prediction models of this kind can be useful for clinical research, health economics, policymaking and clinical decision support...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28821492/use-of-the-low-frequency-high-frequency-ratio-of-heart-rate-variability-to-predict-short-term-deterioration-in-emergency-department-patients-with-sepsis
#2
Douglas P Barnaby, Shannon M Fernando, Kevin J Ferrick, Christophe L Herry, Andrew J E Seely, Polly E Bijur, E John Gallagher
OBJECTIVE: To examine the ability of the low-frequency/high-frequency (LF/HF) ratio of heart rate variability (HRV) analysis to identify patients with sepsis at risk of early deterioration. METHODS: This is a prospective observational cohort study of patients with sepsis presenting to the Montefiore Medical Center ED from December 2014 through September 2015. On presentation, a single ECG Holter recording was obtained and analysed to obtain the LF/HF ratio of HRV...
August 18, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28820925/oxidative-stress-related-molecular-biomarker-candidates-for-glaucoma
#3
Gözde Hondur, Emre Göktas, Xiangjun Yang, Lama Al-Aswad, James D Auran, Dana M Blumberg, George A Cioffi, Jeffrey M Liebmann, Leejee H Suh, Danielle Trief, Gülgün Tezel
Purpose: Glaucoma-related molecular biomarkers can improve clinical testing to diagnose the disease early, predict its prognosis, and monitor treatment responses. Based on the evidence of increased oxidative stress in glaucomatous tissues, this study analyzed oxidative stress-related biomarker candidates in blood and aqueous humor samples with or without glaucoma. Methods: The blood and aqueous humor samples collected from carefully selected groups of 96 patients with glaucoma and 64 healthy subjects without glaucoma were included in the study...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28818537/predicting-grade-and-stage-at-cystoscopy-in-newly-presenting-bladder-cancers-a-prospective-double-blind-clinical-study
#4
Paramananthan Mariappan, Victoria Lavin, Chu Qin Phua, Shahid Aziz Anwar Khan, Roland Donat, Gordon Smith
OBJECTIVES: To assess Urologists' ability to predict the grade and stage of new bladder cancers from the cystoscopic features alone. METHODS: We conducted a prospective clinical study on consecutive patients undergoing Transurethral Resection of Bladder Tumour (TURBT) for new bladder cancers. Using only cystoscopic tumour morphology at the time of initial TURBT, 3 Urology consultants predicted the grade and stage, recording this on a proforma along with tumour features...
August 14, 2017: Urology
https://www.readbyqxmd.com/read/28815681/meta-analytical-synthesis-of-regression-coefficients-under-different-categorization-scheme-of-continuous-covariates
#5
Daisuke Yoneoka, Masayuki Henmi
Recently, the number of clinical prediction models sharing the same regression task has increased in the medical literature. However, evidence synthesis methodologies that use the results of these regression models have not been sufficiently studied, particularly in meta-analysis settings where only regression coefficients are available. One of the difficulties lies in the differences between the categorization schemes of continuous covariates across different studies. In general, categorization methods using cutoff values are study specific across available models, even if they focus on the same covariates of interest...
August 16, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28808361/interleukin-6-an-early-predictive-marker-for-severity-of-acute-pancreatitis
#6
Shilpa A Rao, Aditya R Kunte
BACKGROUND AND AIMS: Interleukin (IL)-6, IL-8, IL-10, and C-reactive protein (CRP) have been evaluated for predicting outcomes of acute pancreatitis. However, there is considerable variation in their performance among different studies. We evaluate their accuracy in predicting progression to severe pancreatitis. MATERIALS AND METHODS: Serum IL-6, IL-8, IL-10, and CRP levels were measured within 24 h of admission in forty patients of clinically predicted severe acute pancreatitis (SAP)...
July 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28804556/anti-tumor-efficacy-evaluation-of-a-novel-monoclonal-antibody-targeting-neutral-amino-acid-transporter-asct2-using-patient-derived-xenograft-mouse-models-of-gastric-cancer
#7
Noriyuki Kasai, Aya Sasakawa, Kenta Hosomi, Tze Wei Poh, Bernadette Lynn Chua, Wei Peng Yong, Jimmy So, Shing Leng Chan, Richie Soong, Koji Kono, Toshihiko Ishii, Kazuya Yamano
ASC amino acid transporter 2 (ASCT2), also known as solute linked carrier family 1 member A5 (SLC1A5) is a Na+-dependent glutamine/neutral amino acid transporter. ASCT2 acts as a high-affinity transporter of L-glutamine (Gln) and has been reported to be up-regulated in a variety of cancerous tissues including stomach, liver, and kidney. In this study, we evaluated anti-tumor efficacy of a novel anti-ASCT2 humanized monoclonal antibody, KM8094, which has a neutralizing activity against glutamine uptake, as a therapeutic antibody against gastric cancer and explored clinical predictive biomarker candidates by utilizing patient-derived xenograft (PDX) mouse models...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28803709/low-back-pain-identifying-sub-groups-clinical-prediction-rules-and-measuring-results
#8
REVIEW
Alan Breen
No abstract text is available yet for this article.
August 3, 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28801412/health-practitioners-perceptions-of-adopting-clinical-prediction-rules-in-the-management-of-musculoskeletal-pain-a-qualitative-study-in-australia
#9
Joan Kelly, Michele Sterling, Trudy Rebbeck, Aila Nica Bandong, Andrew Leaver, Martin Mackey, Carrie Ritchie
OBJECTIVES: To investigate health practitioners' understanding and practice behaviours with regards to clinical prediction rules (CPRs) and explore their perceptions of adopting a new whiplash CPR. DESIGN: Qualitative study using six semistructured focus groups. SETTING: Primary and secondary care in New South Wales and Queensland, Australia. PARTICIPANTS: Physiotherapists (n=19), chiropractors (n=6) and osteopaths (n=3) were purposively sampled to include health practitioners who provide routine treatment to people with whiplash-associated disorders...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28800833/bleeding-risk-scores-in-atrial-fibrillation-and-venous-thromboembolism
#10
REVIEW
Hanis Zulkifly, Gregory Y H Lip, Deirdre A Lane
Patients receiving oral anticoagulant (OAC) therapy for stroke prevention in atrial fibrillation (AF) and prevention of venous thromboembolism (VTE) face an increased risk of bleeding with OAC treatment. Clinicians need to weigh the benefits of OAC treatment against the risk of bleeding. To help formalize bleeding risk assessment, various bleeding risk scores have been developed to help predict the risk of bleeding in AF and VTE patients receiving OAC therapy. This review summarizes the literature involving original studies deriving bleeding risk scores and validation studies of these scores for stroke prevention in AF and treatment/prevention of VTE...
July 14, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28797349/biomarker-based-risk-model-to-predict%C3%A2-cardiovascular-mortality-in-patients%C3%A2-with%C3%A2-stable%C3%A2-coronary%C3%A2-disease
#11
Daniel Lindholm, Johan Lindbäck, Paul W Armstrong, Andrzej Budaj, Christopher P Cannon, Christopher B Granger, Emil Hagström, Claes Held, Wolfgang Koenig, Ollie Östlund, Ralph A H Stewart, Joseph Soffer, Harvey D White, Robbert J de Winter, Philippe Gabriel Steg, Agneta Siegbahn, Marcus E Kleber, Alexander Dressel, Tanja B Grammer, Winfried März, Lars Wallentin
BACKGROUND: Currently, there is no generally accepted model to predict outcomes in stable coronary heart disease (CHD). OBJECTIVES: This study evaluated and compared the prognostic value of biomarkers and clinical variables to develop a biomarker-based prediction model in patients with stable CHD. METHODS: In a prospective, randomized trial cohort of 13,164 patients with stable CHD, we analyzed several candidate biomarkers and clinical variables and used multivariable Cox regression to develop a clinical prediction model based on the most important markers...
August 15, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28790026/dominant-b-cell-receptor-clones-in-peripheral-blood-predict-onset-of-arthritis-in-individuals-at-risk-for-rheumatoid-arthritis
#12
Paul P Tak, Marieke E Doorenspleet, Maria J H de Hair, Paul L Klarenbeek, Marian H van Beers-Tas, Antoine H C van Kampen, Dirkjan van Schaardenburg, Danielle M Gerlag, Frank Baas, Niek de Vries
BACKGROUND: The onset of seropositive rheumatoid arthritis (RA) is preceded by the presence of specific autoantibodies in the absence of synovial inflammation. Only a subset of these at-risk individuals will develop clinical disease. This impedes efforts to implement early interventions that may prevent onset of clinically manifest disease. Here we analyse whether clonal changes in the B cell receptor (BCR) repertoire can reliably predict onset of signs and symptoms. METHODS: In a prospective cohort study in 21 individuals at risk for RA based on the presence of autoantibodies, the BCR repertoire of paired peripheral blood and synovial tissue samples was analysed using next-generation BCR sequencing...
August 8, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28782248/risk-stratification-in-the-investigation-of-pulmonary-nodules-in-a-high-risk-cohort-pet-ct-outperforms-clinical-risk-prediction-algorithms
#13
Glenna Gibson, Aravind Ravi Kumar, Karin Steinke, Farzad Bashirzadeh, Rebecca Roach, Morgan Windsor, Robert Ware, David Fielding
BACKGROUND: Clinical prediction models and 18F-FDG-PET/CT are used for assessment of solitary pulmonary nodules (SPNs) however biopsy is still required before treatment which carries risk. AIM: To determine combined predictive benefit of one such model combined with modern PET/CT data to improve decision making about biopsy prior to treatment and possibly reduce costs. METHOD: Patients with a SPN undergoing 18F-FDG-PET/CT from January 2011-December 2012 were retrospectively identified...
August 7, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28778099/predictive-clinical-model-of-tumor-response-after-chemoradiation-in-rectal-cancer
#14
Marisa D Santos, Cristina Silva, Anabela Rocha, Carlos Nogueira, Fernando Castro-Poças, António Araujo, Eduarda Matos, Carina Pereira, Rui Medeiros, Carlos Lopes
Survival improvement in rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) is achieved only if pathological response occurs. Mandard tumor regression grade (TRG) proved to be a valid system to measure nCRT response. The ability to predict tumor response before treatment may significantly have impact the selection of patients for nCRT in rectal cancer. The aim is to identify potential predictive pretreatment factors for Mandard response and build a clinical predictive model design. 167 patients with locally advanced rectal cancer were treated with nCRT and curative surgery...
July 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28764868/modeling-new-immunoregulatory-therapeutics-as-antimicrobial-alternatives-for-treating-clostridium-difficile-infection
#15
Andrew Leber, Raquel Hontecillas, Vida Abedi, Nuria Tubau-Juni, Victoria Zoccoli-Rodriguez, Caroline Stewart, Josep Bassaganya-Riera
The current treatment paradigm in Clostridium difficile infection is the administration of antibiotics contributing to the high rates of recurrent infections. Recent alternative strategies, such as fecal microbiome transplantation and anti-toxin antibodies, have shown similar efficacy in the treatment of C. difficile associated disease (CDAD). However, barriers exist for either treatment or other novel treatments to displace antibiotics as the standard of care. To aid in the comparison of these and future treatments in CDAD, we developed an in silico pipeline to predict clinical efficacy with nonclinical results...
May 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28754819/tumor-purity-as-an-underlying-key-factor-in-glioma
#16
Chuan-Bao Zhang, Wen Cheng, Xiufang Ren, Zheng Wang, Xing Liu, Guanzhang Li, Sheng Han, Tao Jiang, Anhua Wu
 <span style="font-size: 11px;">Glioma tissues consist not only of glioma cells but also glioma-associated non-tumor cells, such as stromal cells and immune cells. These non-tumor cells dilute the purity of glioma cells and play important roles in glioma biology. Currently, the implications of variation in glioma purity are not sufficiently clarified.</span><br /><br /><br />Experimental Design: <span style="font-size: 11px;">Here, tumor purity was inferred for 2249 gliomas and 29 normal brain tissues from five cohorts...
July 28, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28748088/modeling-risk-for-developing-drug-resistant-bacterial-infections-in-an-mdr-naive-critically-ill-population
#17
Rajiv Sonti, Megan E Conroy, Elena M Welt, Yi Hu, George Luta, Daniel B Jamieson
PURPOSE: To create a model predictive of an individual's risk of developing a de novo multidrug-resistant (MDR) infection while in the intensive care unit (ICU). METHODS: This is a case-control study in which 189 ICU patients diagnosed with their first infection with an MDR organism were compared on the basis of demographic, past medical and clinical variables to randomly selected ICU patients without such an infection, era-matched in a 2:1 ratio. A prediction tool was derived using multivariate logistic regression...
July 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28741093/fetal-right-ventricular-prominence-associated-postnatal-abnormalities-and-coarctation-clinical-prediction-tool
#18
Alyssa Power, Alberto Nettel-Aguirre, Deborah Fruitman
Fetal right ventricular (RV) prominence is a known indicator of possible left-sided structural heart disease with a low positive predictive value for aortic coarctation. There is a paucity of data on identifying which fetuses with RV prominence will have postnatal arch obstruction. Our study objectives were to create a clinical prediction tool for coarctation and to describe the diagnostic outcomes of our cohort with fetal RV prominence. We performed a retrospective review of patients referred with fetal RV prominence from January 2009 to October 2015...
July 24, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28732643/development-and-internal-validation-of-a-prediction-model-to-estimate-the-probability-of-needing-aggressive-immunosuppressive-therapy-with-cytostatics-in-de-novo-lupus-nephritis-patients
#19
Mauricio Restrepo-Escobar, Paula Andrea Granda-Carvajal, Fabián Jaimes
OBJECTIVE: To develop a multivariable clinical prediction model for the requirement of aggressive immunosuppression with cytostatics, based on simple clinical record data and lab tests. The model is defined in accordance with the result of the kidney biopsies. METHODS: Retrospective study conducted with data from patients 16 years and older, with SLE and nephritis with less than 6 months of evolution. An initial bivariate analysis was conducted to select the variables to be included in a multiple logistic regression model...
July 18, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28728604/target-d-a-stratified-individually-randomized-controlled-trial-of-the-diamond-clinical-prediction-tool-to-triage-and-target-treatment-for-depressive-symptoms-in-general-practice-study-protocol-for-a-randomized-controlled-trial
#20
Jane Gunn, Caroline Wachtler, Susan Fletcher, Sandra Davidson, Cathrine Mihalopoulos, Victoria Palmer, Kelsey Hegarty, Amy Coe, Elizabeth Murray, Christopher Dowrick, Gavin Andrews, Patty Chondros
BACKGROUND: Depression is a highly prevalent and costly disorder. Effective treatments are available but are not always delivered to the right person at the right time, with both under- and over-treatment a problem. Up to half the patients presenting to general practice report symptoms of depression, but general practitioners have no systematic way of efficiently identifying level of need and allocating treatment accordingly. Therefore, our team developed a new clinical prediction tool (CPT) to assist with this task...
July 20, 2017: Trials
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