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https://www.readbyqxmd.com/read/28935225/heart-rate-variability-biofeedback-and-other-psychophysiological-procedures-as-important-elements-in-psychotherapy
#1
REVIEW
Paul Lehrer
Lang's distinction of psychophysiological, behavioral, and cognitive domains in psychological problems and therapies provides a useful heuristic for guiding psychotherapy. Much psychotherapy practice emphasizes the cognitive domain, but behavioral and psychophysiological interventions show at least equivalent effectiveness for some kinds of problems. Most descriptions of cognitive behavior therapy emphasize cognitive procedures, although most CBT approaches also incorporate behavioral interventions such as social skills training, exposure, and behavior activation...
September 18, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28929048/brand-versus-generic-dispensing-trend-for-ciprofloxacin-500-mg-levofloxacin-500-mg-and-moxifloxacin-400-mg-oral-dosage-forms-among-pharmacies-of-karachi-pakistan
#2
Fatima Zehra, Atta Abbas Naqvi, Sumbul Tasneem, Rizwan Ahmad, Niyaz Ahmad, Adnan Zia Shamsi, Naqiya Ali Asghar, Ghufran Ullah Khan
INTRODUCTION: Pakistan spends 0.7% of its gross domestic product on health. The public sector health-care system provides services to 22% of population thus paving the way for a dominant private sector. Patients in Pakistan mostly pay their medical expenses directly, and 64% of the health expenditures are borne by the household. Expenditure on medicine constitutes 43% of the total household expenditure. METHODS: A quantitative cross-sectional study was conducted in Karachi, Pakistan, for a month...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28927676/a-pilot-study-to-expand-treatment-of-chronic-hepatitis-c-in-resource-limited-settings
#3
REVIEW
Poonam Mathur, Emily Comstock, Edward McSweegan, Natalia Mercer, Nongthombam Suraj Kumar, Shyamasundaran Kottilil
The past five years have seen a revolution in the treatment of chronic hepatitis C, as short duration oral regimens of direct-acting antiviral drugs (DAAs), with nearly 100% cure rates for all genotypes, have replaced longer courses of ribavirin and injected interferon. Although initially very expensive, these DAAs are now becoming available in generic equivalents in countries with large numbers of chronically infected people, such as India. However, a number of obstacles may hinder the delivery of these drugs in resource-limited settings, including lack of access to diagnostic testing and the restriction of treatment to a small number of medical specialists...
September 16, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28925419/mosaicqa-a-general-approach-to-facilitate-basic-data-quality-assurance-for-epidemiological-research
#4
Martin Bialke, Henriette Rau, Thea Schwaneberg, Rene Walk, Thomas Bahls, Wolfgang Hoffmann
BACKGROUND: Epidemiological studies are based on a considerable amount of personal, medical and socio-economic data. To answer research questions with reliable results, epidemiological research projects face the challenge of providing high quality data. Consequently, gathered data has to be reviewed continuously during the data collection period. OBJECTIVES: This article describes the development of the mosaicQA-library for non-statistical experts consisting of a set of reusable R functions to provide support for a basic data quality assurance for a wide range of application scenarios in epidemiological research...
May 29, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28921732/from-medico-administrative-databases-analysis-to-care-trajectories-analytics-an-example-with-the-french-snds
#5
Erwan Drezen, Thomas Guyet, André Happe
Medico-administrative data like SNDS (Système National de Données de Santé) are not collected initially for epidemiological purposes. Moreover, the data model and the tools proposed to SNDS users make their in-depth exploitation difficult. We propose a data model, called the ePEPS model, based on health care trajectories to provide a medical view of raw data. A data abstraction process enables the clinician to have an intuitive medical view of raw data and to design a study-specific view. This view is based on a generic model of care trajectory, i...
September 16, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28920521/implementing-evidence-based-smoking-cessation-treatment-in-psychosocial-care-units-caps-in-brazil
#6
João Mauricio Castaldelli-Maia, Nilson R da Silva, Marta Rd Campos, Helena F Moura, Gustavo Zabert, Beatriz M Champagne, Katherine E Kemper, J Taylor Hays
BACKGROUND: The prevalence of smoking among mental health and addiction (MHA) patients is 3 times higher than it is in the general population, yet this patient population has received little help to combat smoking. Considering this, psychosocial care centers (CAPS - Centros de Atenção Psicossocial) are strategic locations for integrating tobacco dependence treatment (TDT) into existing treatment activities. METHODS: Our team provided an 8-hour training package to the staff of CAPS that have not been providing specialized TDT for smokers...
September 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28919797/quality-of-care-in-inflammatory-bowel-disease-results-of-a-prospective-controlled-cohort-study-in-germany-netibd
#7
Jana Langbrandtner, Angelika Hüppe, Petra Jessen, Jürgen Büning, Susanna Nikolaus, Heiner Raspe, Bernd Bokemeyer
BACKGROUND/AIMS: Patients with inflammatory bowel disease (IBD) need comprehensive, interdisciplinary and cross-sectoral health care. In Germany, evidence-based care pathways have been developed to improve the quality of care of IBD patients. We aimed to evaluate the effects of the implementation of some of these recommendations on patient-related outcomes. METHODS: In a region of North Germany, outpatients with IBD were recruited by gastroenterologists (intervention group)...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28919103/alterations-of-musculoskeletal-models-for-a-more-accurate-estimation-of-lower-limb-joint-contact-forces-during-normal-gait-a-systematic-review
#8
REVIEW
F Moissenet, L Modenese, R Dumas
Musculoskeletal modelling is a methodology used to investigate joint contact forces during a movement. High accuracy in the estimation of the hip or knee joint contact forces can be obtained with subject-specific models. However, construction of subject-specific models remains time consuming and expensive. The purpose of this systematic review of the literature was to identify what alterations can be made on generic (i.e. literature-based, without any subject-specific measurement other than body size and weight) musculoskeletal models to obtain a better estimation of the joint contact forces...
September 1, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28910513/quality-of-life-outcomes-following-pediatric-lung-transplantation
#9
Tanya Lazor, Hartmut Grasemann, Melinda Solomon, Samantha J Anthony
PURPOSE: Compared to other solid organs, survival after lung transplantation (LTx) is still poor. Discussions on survival benefits following LTx in children, however, have largely concentrated on medical outcome data. Little research describes quality of life (QoL) of pediatric LTx recipients, which is partly due to the small number of pediatric LTxs performed. Only two centers worldwide performed >10 pediatric LTxs in 2013, making data on QoL in this population difficult to obtain...
September 14, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28906080/persistence-and-adherence-with-mirabegron-vs-antimuscarinics-in-overactive-bladder-retrospective-analysis-of-a-uk-general-practice-prescription-database
#10
Adrian S Wagg, Steve Foley, John Peters, Jameel Nazir, Leanne Kool-Houweling, Ludmila Scrine
INTRODUCTION AND OBJECTIVES: Persistence with antimuscarinic (AM) drugs prescribed for overactive bladder (OAB) is poor. This study aimed to compare persistence and adherence with the beta-3-adrenoceptor agonist mirabegron (MIR) vs AMs over 12 months. PATIENTS AND METHODS: This retrospective cohort analysis included patients aged ≥18 years who were prescribed MIR, or any AM. A 12-month look-back was used to assess inclusion eligibility. The primary end-point was persistence, defined as time to first discontinuation of index drug, during 1 year follow-up...
September 14, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28903978/antihyperglycemic-medications-a-claims-based-estimate-of-first-line-therapy-use-before-initialization-of-second-line-medications
#11
Yi-Ju Tseng, Gregory Steinberg, Kathe P Fox, Joanne Armstrong, Kenneth D Mandl
OBJECTIVE: The American Diabetes Association recommends metformin as first-line therapy for type 2 diabetes. However, nonadherence to antihyperglycemic medication is common, and a clinician could confuse nonadherence with pharmacologic failure, potentially leading to premature prescribing of second-line therapies. We measured metformin use before second-line therapy initialization. RESEARCH DESIGN AND METHODS: This retrospective cross-sectional study used unidentifiable member claims data from individuals covered from 2010 to 2015 by Aetna, a U...
September 13, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28898969/job-specific-mandatory-medical-examinations-for-the-police-force
#12
J S Boschman, C T J Hulshof, M H W Frings-Dresen, J K Sluiter
Background: Mandatory medical examinations (MMEs) of workers should be based on the health and safety requirements that are needed for effectively performing the relevant work. For police personnel in the Netherlands, no job-specific MME exists that takes the specific tasks and duties into account. Aims: To provide the Dutch National Police with a knowledge base for job-specific MMEs for police personnel that will lead to equitable decisions from an occupational health perspective about who can perform police duties...
August 1, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28892528/determinants-of-market-exclusivity-for-prescription-drugs-in-the-united-states
#13
Aaron S Kesselheim, Michael S Sinha, Jerry Avorn
The high prices of brand-name prescription drugs are a growing source of controversy in the United States. Manufacturers of brand-name drugs can command high prices because they are protected from generic competition by two types of government-granted monopoly rights. The first are patents on the drugs that generally define the basic period of brand-name-only sales. The second is awarded at the time of US Food and Drug Administration (FDA) approval and usually defines the minimum time until a generic can be sold...
September 11, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28892437/public-health-system-research-in-public-health-emergency-preparedness-in-the-united-states-2009-2015-actionable-knowledge-base
#14
REVIEW
Elena Savoia, Leesa Lin, Dottie Bernard, Noah Klein, Lyndon P James, Stefano Guicciardi
BACKGROUND: In 2008, the Institute of Medicine released a letter report identifying 4 research priority areas for public health emergency preparedness in public health system research: (1) enhancing the usefulness of training, (2) improving timely emergency communications, (3) creating and maintaining sustainable response systems, and (4) generating effectiveness criteria and metrics. OBJECTIVES: To (1) identify and characterize public health system research in public health emergency preparedness produced in the United States from 2009 to 2015, (2) synthesize research findings and assess the level of confidence in these findings, and (3) describe the evolution of knowledge production in public health emergency preparedness system research...
September 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28889650/correlation-of-recommendations-of-treatment-guidelines-and-frequently-prescribed-antibiotics-evaluation-of-their-pharmaceutical-pack-size
#15
Shoma Mukherjee, Nilanjan Saha
There are various factors that contribute to development of antimicrobial resistance. Overuse, inappropriate prescribing and extensive agricultural use of antibiotics are some of the factors which have been identified. Antibiotics are almost always universally packaged by manufacturers in packs that are heavily driven by cost of economies and convenience rather than by any scientific basis or duration of therapy. So, in the present study, the correlation of the treatment guidelines with the choice of antibiotics and whether packing size contributes to left-over dosing units when used according to guideline recommendations were assessed...
September 10, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28887749/perceived-medication-adherence-barriers-mediating-effects-between-gastrointestinal-symptoms-and-health-related-quality-of-life-in-pediatric-inflammatory-bowel-disease
#16
James W Varni, Robert J Shulman, Mariella M Self, Shehzad A Saeed, George M Zacur, Ashish S Patel, Samuel Nurko, Deborah A Neigut, James P Franciosi, Miguel Saps, Jolanda M Denham, Chelsea Vaughan Dark, Cristiane B Bendo, John F Pohl
OBJECTIVES: The primary objective was to investigate the mediating effects of patient-perceived medication adherence barriers in the relationship between gastrointestinal symptoms and generic health-related quality of life (HRQOL) in adolescents with inflammatory bowel disease (IBD). The secondary objective explored patient health communication and gastrointestinal worry as additional mediators with medication adherence barriers in a serial multiple mediator model. METHODS: The Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms, Medicines, Communication, Gastrointestinal Worry, and Generic Core Scales were completed in a 9-site study by 172 adolescents with IBD...
September 8, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28885222/opinions-of-maltese-doctors-and-pharmacists-on-medication-errors
#17
Amy Tanti, Miriam Camilleri, Andrew A Borg, Benjamin Micallef, Gavril Flores, Anthony Serracino-Inglott, John Joseph Borg
BACKGROUND: Pharmacovigilance directive 2010/84/EU focused attention on medication errors and encouraged regulators to identify causing and contributing factors. OBJECTIVES: (1) To study opinions of doctors/pharmacists on factors bearing a causal link to MEs as well as ways to minimise MEs (2) to test whether differences in opinion exist between subgroups of doctors and pharmacists working in community, hospital or office settings. METHODS: Different questionnaires were circulated to doctors and pharmacists...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28883196/from-a-content-delivery-portal-to-a-knowledge-management-system-for-standardized-cancer-documentation
#18
Danijela Schlue, Sebastian Mate, Jörg Haier, Dennis Kadioglu, Hans-Ulrich Prokosch, Bernhard Breil
Heterogeneous tumor documentation and its challenges of interpretation of medical terms lead to problems in analyses of data from clinical and epidemiological cancer registries. The objective of this project was to design, implement and improve a national content delivery portal for oncological terms. Data elements of existing handbooks and documentation sources were analyzed, combined and summarized by medical experts of different comprehensive cancer centers. Informatics experts created a generic data model based on an existing metadata repository...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28883166/standards-based-procedural-phenotyping-the-arden-syntax-on-i2b2
#19
Sebastian Mate, Ixchel Castellanos, Thomas Ganslandt, Hans-Ulrich Prokosch, Stefan Kraus
Phenotyping, or the identification of patient cohorts, is a recurring challenge in medical informatics. While there are open source tools such as i2b2 that address this problem by providing user-friendly querying interfaces, these platforms lack semantic expressiveness to model complex phenotyping algorithms. The Arden Syntax provides procedural programming language construct, designed specifically for medical decision support and knowledge transfer. In this work, we investigate how language constructs of the Arden Syntax can be used for generic phenotyping...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28880625/biosimilar-monoclonal-antibodies-mabs-in-oncology
#20
Caroline Moore
Biological medicines are derived from living cells and organisms. Monoclonal antibodies (mAbs) are biological agents that are widely used to treat malignancies including non-Hodgkin's lymphomas and chronic lymphocytic leukaemia. They are effective but expensive. The patents for many mAbs are expiring, so biosimilar medicines, which contain a version of the active ingredient of the original drug, are being developed. Biological medicines cannot be assessed in the same way as standard generic medications because they are difficult to copy and can change over time...
September 7, 2017: British Journal of Nursing: BJN
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