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https://www.readbyqxmd.com/read/29144957/fluconazole-levels-in-serum-and-cerebrospinal-fluid-according-to-daily-dosage-in-patients-with-cryptococcosis-and-other-fungal-infections
#1
Letícia Aparecida Schiave, Erika Nascimento, Fernando Crivelenti Vilar, Tissiana Marques de Haes, Osvaldo Massaiti Takayanagui, Cristiane Masetto de Gaitani, Roberto Martinez
Fluconazole is extensively used for the treatment of candidiasis and cryptococcosis. Among other factors, successful treatment is related to appropriate fluconazole levels in blood and cerebrospinal fluid (CSF). In the present study, fluconazole levels were determined in 15 patients, 14 of whom had AIDS and 13 had neurocryptococcosis. The only selection criterion was treatment with fluconazole, which was performed with a generic or similar form of the drug. Fluconazole level was determined by high performance liquid chromatography and the susceptibility profile of Cryptococcus spp...
November 13, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29143899/headache-in-resource-limited-settings
#2
REVIEW
Yohannes W Woldeamanuel
PURPOSE OF REVIEW: This review summarizes the unmet need of headache burden and management in resource-limited settings. It provides a general overview of the nuances and peculiarities of headache disorders in resource-limited settings. The review delivers perspectives and explanations for the emerging burden of both primary and secondary headache disorders. Important discussion on demographic and epidemiologic transition pertinent to low-resource settings is included. A critical analysis of headache disorders is made within the context of growing burden non-communicable disorders in low-resource countries...
November 16, 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29142086/shortage-of-generic-neurologic-therapeutics-an-escalating-threat-to-patient-care
#3
Jacklyn O Omorodion, Rami M Algahtani, Mark S Zocchi, Erin R Fox, Jesse M Pines, Henry J Kaminski
OBJECTIVE: To assess longitudinal trends in shortages of generic drugs used for neurologic conditions over a 15-year period in the United States. METHODS: Drug shortage data from the University of Utah Drug Information Service (UUDIS) from 2001 to 2015 were analyzed. Medications were included that were likely to be prescribed by a neurologist to treat a primary neurologic condition or critical for care of a patient with a neurologic condition. Trends in shortage length were assessed using standard descriptive statistics...
November 15, 2017: Neurology
https://www.readbyqxmd.com/read/29141645/measuring-quality-of-life-among-people-living-with-hiv-a-systematic-review-of-reviews
#4
REVIEW
Vanessa Cooper, Jane Clatworthy, Richard Harding, Jennifer Whetham
AIM: A systematic review of reviews was conducted to identify and appraise brief measures of health-related quality of life (HRQoL) that have been used in peer-reviewed research with people living with HIV. METHODS: The review was conducted in two stages: 1) search of electronic databases to identify systematic reviews of tools used to measure HRQoL in adults living with HIV, published since the year 2000; 2) selection of HRQol scales from those identified in the reviews...
November 15, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29141265/-hbv-infections-in-germany-health-care-costs-in-a-real-life-setting
#5
Jona Theodor Stahmeyer, Hans Becker, Anna Lena Orlemann, Christian Krauth, Michael P Manns, Heiner Wedemeyer
Background An estimated 500 000 people are infected with hepatitis B in Germany, inducing an enormous burden on infected patients and the health care system. The aim of our study was to estimate the real-life costs of treating hepatitis B and to analyze sociodemographic factors. Methods We conducted a retrospective, non-interventional, single-center study from 07/2009 to 12/2012. Information on health care delivery was extracted from patient records. Besides that, a questionnaire survey regarding sociodemographic parameters and quality of life of HBV-infected patients was performed...
November 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29140978/adherence-to-inhaled-therapies-of-copd-patients-from-seven-latin-american-countries-the-lassyc-study
#6
Maria Montes de Oca, Ana Menezes, Fernando C Wehrmeister, Maria Victorina Lopez Varela, Alejandro Casas, Luis Ugalde, Alejandra Ramirez-Venegas, Laura Mendoza, Ana López, Filip Surmont, Marc Miravitlles
BACKGROUND: This study assessed the adherence profiles to inhaled therapies and the agreement between two patient self-report adherence methods in stable COPD lpatients from seven Latin American countries. METHODS: This observational, cross-sectional, multinational, multicenter study involved 795 COPD patients (post-bronchodilator forced expiratory volume in 1 second/forced vital capacity [FEV1/FVC] <0.70). Adherence to inhaled therapy was assessed using the specific Test of Adherence to Inhalers (10-item TAI) and the generic 8-item Morisky Medication Adherence Scale (MMAS-8) questionnaires...
2017: PloS One
https://www.readbyqxmd.com/read/29140637/hazard-identification-and-risk-assessment-for-improving-farm-safety-on-canadian-farms
#7
Hassan S Chattha, Kenneth W Corscadden, Qamar U Zaman
Agriculture is one of the most hazardous industries worldwide. The number of serious accidents on farms, despite sophisticated technology, development of effective prevention methods, and high-quality training and improved skill levels of farmers, is still very high. The purpose of this study was to develop and apply a generic farm safety protocol to hazards that have been identified in previously published literature and demonstrate the potential benefits of such a protocol with a view to raising awareness of farm safety...
July 31, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29134668/factors-affecting-patient-reported-outcomes-after-red-blood-cell-transfusion-in-medical-patients
#8
Ka Lok Luke Chan, Wai Man Vivien Mak, Yat Hung Tam, Kwok Kuen Harold Lee
BACKGROUND: Physical variables like mortality or cardiac events were used to evaluate the requirement of red blood cell (RBC) transfusion. However, patient-reported outcomes (PROs) of blood transfusion recipients were seldom assessed. The health-related quality of life (HRQoL) of patients before and after RBC transfusion was compared in this study. STUDY DESIGN AND METHODS: The study period was February to June 2016. Standardized generic and anemia symptom-specific HRQoL instruments were administered to patients receiving RBC transfusion in the medical unit of a single center...
November 13, 2017: Transfusion
https://www.readbyqxmd.com/read/29132622/know-thy-ehealth-user-development-of-biopsychosocial-personas-from-a-study-of-older-adults-with-heart-failure
#9
Richard J Holden, Anand Kulanthaivel, Saptarshi Purkayastha, Kathryn M Goggins, Sunil Kripalani
BACKGROUND: Personas are a canonical user-centered design method increasingly used in health informatics research. Personas-empirically-derived user archetypes-can be used by eHealth designers to gain a robust understanding of their target end users such as patients. OBJECTIVE: To develop biopsychosocial personas of older patients with heart failure using quantitative analysis of survey data. METHOD: Data were collected using standardized surveys and medical record abstraction from 32 older adults with heart failure recently hospitalized for acute heart failure exacerbation...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29128411/psychometric-properties-of-the-kidney-disease-quality-of%C3%A2-life-36-item-short-form-survey-kdqol-36-in-the%C3%A2-united%C3%A2-states
#10
John D Peipert, Peter M Bentler, Kristi Klicko, Ron D Hays
BACKGROUND: The Centers for Medicare & Medicaid Services require that dialysis patients' health-related quality of life be assessed annually. The primary instrument used for this purpose is the Kidney Disease Quality of Life 36-Item Short-Form Survey (KDQOL-36), which includes the SF-12 as its generic core and 3 kidney disease-targeted scales: Burden of Kidney Disease, Symptoms and Problems of Kidney Disease, and Effects of Kidney Disease. Despite its broad use, there has been limited evaluation of KDQOL-36's psychometric properties...
November 8, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29127142/can-reference-images-improve-interobserver-agreement-in-reporting-liver-fibrosis
#11
Alyn L German, Kenneth Fleming, Philip Kaye, Susan Davies, Robert Goldin, Stefan G Hubscher, Dina Tiniakos, Angus McGregor, Judith I Wyatt
Staging of fibrosis in medical liver biopsies has inherent interobserver variability. There are a number of disease-specific scoring systems available. While recognising the importance of these scoring systems, there is scope to consider how concordance amongst histopathologists could be improved using a generic fibrosis staging system.Using virtual slides, we approached both specialist liver histopathologists and general histopathologists from the UK to assess the degree of fibrosis against a proposed four-tiered reporting system...
November 10, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29120716/cost-comparison-of-commonly-used%C3%A2-postoperative-topical-ophthalmic%C3%A2-antibiotics
#12
Eric L Crowell, Vivek A Koduri, R Scott Groat, David A Lee
PURPOSE: To provide information on the actual fill level and cost of currently available antibiotic drops used perioperatively. DESIGN: Prospective laboratory investigation. SETTING: Robert Cizik Eye Clinic, Houston, Texas USA. METHODS: The following 9 medications were tested: moxifloxacin, gatifloxacin (branded and generic), besifloxacin, levofloxacin, ciprofloxacin, ofloxacin, trimethoprim/polymyxin B, tobramycin, and gentamicin...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29118588/professionalism-among-paramedic-students-achieving-the-measure-or-missing-the-mark
#13
REVIEW
L Michael Bowen, Brett Williams, Luke Stanke
Background: Professionalism is a pillar of paramedicine. Internationally paramedic curricula emphasize valid assessment of three domains: cognitive, psychomotor, and affective domains (professionalism). Little is reported on competency measures for professionalism specific to paramedicine. Literature suggests that paramedic students, paramedic practitioners, medical directors, and patients believe that professional attributes should have an increased focus. Objective: The objective of this scoping review is to outline valid and reliable assessments that evaluate professional behaviors...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29114561/awareness-about-rational-use-of-medicines-among-fresh-bachelor-of-medicine-and-bachelor-of-surgery-graduates
#14
Vijaya Laxman Chaudhari, Smita N Mali, Amruta V Dawari, Tushar B Nishandar
CONTEXT: Fresh Bachelor of Medicine and Bachelor of Surgery graduates (FMGs) are responsible for the majority of prescription errors and irrational use of medicines. Little research has explored their knowledge on rational prescribing practices. AIMS: The present study aimed to evaluate the awareness of rational use of medicines (RUMs) among the FMGs. SETTINGS AND DESIGN: A multicentric, cross-sectional, and questionnaire-based study was conducted among 308 FMGs during the internship orientation program...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29113922/current-japanese-regulatory-systems-for-generics-and-biosimilars
#15
Ryosuke Kuribayashi, Kenji Sawanobori
Currently, biosimilar products are being actively developed around the world. One reason for this is the expiry of patents of original biopharmaceutical products with an extremely large market share because the biosimilar companies need to avoid infringing patents. A representative example of this is biosimilar versions of monoclonal antibodies. In Japan, the Ministry of Health, Labour and Welfare is promoting the use of biosimilar products because the market share of such products is currently extremely low compared with that of generic products...
November 4, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29109755/geometrical-frustration-yields-fiber-formation-in-self-assembly
#16
Martin Lenz, Thomas A Witten
Controlling the self-assembly of supramolecular structures is vital for living cells, and a central challenge for engineering at the nano- and microscales [1, 2]. Nevertheless, even particles without optimized shapes can robustly form well-defined morphologies. This is the case in numerous medical conditions where normally soluble proteins aggregate into fibers [3, 4]. Beyond the diversity of molecular mechanisms involved [5, 6], we propose that fibers generically arise from the aggregation of irregular particles with short-range interactions...
November 2017: Nature Physics
https://www.readbyqxmd.com/read/29105871/cost-effectiveness-of-personal-tailored-risk-information-and-taster-sessions-to-increase-the-uptake-of-the-nhs-stop-smoking-services-the-start2quit-randomised-controlled-trial
#17
Qi Wu, Hazel Gilbert, Irwin Nazareth, Stephen Sutton, Richard Morris, Irene Petersen, Simon Galton, Steve Parrott
AIMS: To assess the cost-effectiveness of a two-component intervention designed to increase attendance at the NHS Stop Smoking Services (SSSs) in England. DESIGN: Cost-effectiveness analysis alongside a randomised controlled trial (Start2quit). SETTING: NHS SSS and general practices in England. PARTICIPANTS: The study comprised 4,384 smokers aged 16 or over identified from medical records in 99 participating practices, who were motivated to quit and had not attended the SSS in the previous 12 months...
November 4, 2017: Addiction
https://www.readbyqxmd.com/read/29101617/quality-of-medication-information-in-discharge-summaries-from-hospitals-an-audit-of-electronic-patient-records
#18
Beate Hennie Garcia, Berit Svendsen Djønne, Frode Skjold, Ellen Marie Mellingen, Trine Iversen Aag
Background Low quality of medication information in discharge summaries from hospitals may jeopardize optimal therapy and put the patient at risk for medication errors and adverse drug events. Objective To audit the quality of medication information in discharge summaries and explore factors associated with the quality. Setting Helgelandssykehuset Mo i Rana, a rural hospital in central Norway. Method For each month in 2013, we randomly selected 60 discharge summaries from the Department of Medicine and Surgery (totally 720) and evaluated the medication information using eight Norwegian quality criteria...
November 3, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29099732/error-in-drugs-consumption-among-older-patients
#19
Yosefa Bar-Dayan, Thomas Shotashvily, Mona Boaz, Julio Wainstein
The cost effectiveness of generic drugs has promoted their use worldwide. However, the large variety of bioequivalent generic and brand-name drugs found in the marketplace increases the complexity and frequency of mistakes in drug consumption. This clinical study investigated the prevalence of various mistakes in drug consumption by patients using a hospital setting. This prospective clinical trial used a hospital setting to identify errors in drug consumption. Six hundred patients who were hospitalized for a minimum of 48 hours in the Internal Medicine Departments were checked at various time points...
November 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29097793/patient-reported-outcome-and-experience-measures-of-oral-disease-in-oral-medicine
#20
R Ní Ríordáin, P Wiriyakijja
A recent meeting of health ministers from over 40 countries worldwide deemed that time and money should be spent on outcome and experience measures that would allow us to determine whether our health systems deliver outcomes that truly matter to patients. This meeting, along with recent national programmes to promote the use of outcome measures in evaluating medical and surgical interventions, highlighted the important role that patient reported outcome measures (PROMs) and patient reported experience measures (PREMs) have in healthcare...
December 2017: British Dental Journal
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