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https://www.readbyqxmd.com/read/29322473/pharmaceutical-care-and-health-related-quality-of-life-outcomes-over-the-past-25%C3%A2-years-have-we-measured-dimensions-that-really-matter
#1
REVIEW
Mohammed A Mohammed, Rebekah J Moles, Timothy F Chen
Background Several measures of Health-Related Quality of Life (HRQoL) have been used to evaluate Pharmaceutical Care (PC) interventions in the past decades. However, their suitability for evaluation of PC services has not been comprehensively evaluated. Aim of the review The aim of this review was to perform content analysis of HRQoL measures used in PC studies to gain an insight into their suitability for evaluation of PC services. Method PC studies evaluating HRQoL as a primary or secondary outcomes were retrieved based on a literature search of articles published from 1990 to 2015, on Medline, Embase, International Pharmaceutical Abstracts, Global Health, PsycInfo, Web of Science, Cinahl, HealthStar, Cochrane Library, AUSThealth, Australian Medical Index, and Current content...
January 10, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29322470/associations-between-the-drug-burden-index-potentially-inappropriate-medications-and-quality-of-life-in-residential-aged-care
#2
Stephanie L Harrison, Lisa Kouladjian O'Donnell, Clare E Bradley, Rachel Milte, Suzanne M Dyer, Emmanuel S Gnanamanickam, Enwu Liu, Sarah N Hilmer, Maria Crotty
BACKGROUND: Inappropriate polypharmacy may negatively impact the quality of life of residents in aged care facilities, but it remains unclear which medications may influence this reduced quality of life. OBJECTIVE: The objective of this study was to examine whether the Drug Burden Index and potentially inappropriate medications were associated with quality of life in older adults living in residential care with a high prevalence of cognitive impairment and dementia...
January 11, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29316718/label-free-sensors-based-on-graphene-field-effect-transistors-for-the-detection-of-human-chorionic-gonadotropin-cancer-risk-biomarker
#3
Carrie Haslam, Samar Damiati, Toby Whitley, Paul Davey, Emmanuel Ifeachor, Shakil A Awan
We report on the development of label-free chemical vapour deposition (CVD) graphene field effect transistor (GFET) immunosensors for the sensitive detection of Human Chorionic Gonadotropin (hCG), a glycoprotein risk biomarker of certain cancers. The GFET sensors were fabricated on Si/SiO₂ substrate using photolithography with evaporated chromium and sputtered gold contacts. GFET channels were functionalised with a linker molecule to an immobile anti-hCG antibody on the surface of graphene. The binding reaction of the antibody with varying concentration levels of hCG antigen demonstrated the limit of detection of the GFET sensors to be below 1 pg/mL using four-probe electrical measurements...
January 8, 2018: Diagnostics
https://www.readbyqxmd.com/read/29315859/medical-and-economic-factors-influencing-generic-drug-use-in-the-japanese-public-health-system-influencing-factors-in-different-populations
#4
Tomoya Tachi, Kosuke Saito, Hiroki Esaki, Yuta Kanematsu, Aki Yoshida, Ikuto Sugita, Yoshihiro Noguchi, Teppei Makino, Michi Umeda, Masahiro Yasuda, Takashi Mizui, Chitoshi Goto, Hitomi Teramachi
Factors influencing generic drug use must be considered when new drug policies are established and initiatives are implemented to promote generic drug use. This study was conducted to elucidate medical and economic factors that influence generic drug use in the Japanese public health system by evaluating the degree of generic drug use via a multivariate analysis. We conducted a retrospective study of medications administered to inpatients at Gifu Municipal Hospital (Japan) from November 1 to 14, 2014. Details of inpatients (age, sex, and type of medical insurance) and the drugs administered (prescribing institution, dispensing pharmacy, price, and class) were assessed...
January 8, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29302104/a-clinical-trial-investigating-the-impact-of-in-feed-flavophospholipol-on-salmonella-shedding-and-antimicrobial-resistance-in-pigs
#5
Saranya Nair, Abdolvahab Farzan, Terri L O'Sullivan, Robert M Friendship
A clinical trial was conducted to assess the effectiveness of in-feed flavophospholipol in reducing Salmonella shedding and antimicrobial resistance (AMR) associated with Salmonella and generic Escherichia coli in naturally infected grower-finisher pigs. Pigs were obtained from a farm with a history of salmonellosis and were housed at a research facility. Over the span of 10 weeks the pigs received either a feed containing 4 ppm of flavophospholipol (treatment, n = 25) or a non-medicated feed (control, n = 20)...
January 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29300350/exploring-the-knowledge-and-perception-of-generic-medicines-among-final-year-undergraduate-medical-pharmacy-and-nursing-students-in-sierra-leone-a-comparative-cross-sectional-approach
#6
Peter Bai James, Abdulai Jawo Bah, Emmanuel Kamanda Margao, Christian Hanson, John Alimamy Kabba, Shazia Qasim Jamshed
Most low-income nations have national medicine policy that emphasized the use of generic medicines in the public health sector. However, the use of generics is often debatable as there are concerns over its efficacy, quality, and safety compared to their branded counterparts. This study was conducted to compare the knowledge and perception of generic medicines among final year undergraduate medical, pharmacy, and nursing students in Sierra Leone. We conducted a questionnaire-based cross-sectional study among these students at the College of Medicine and Allied Health Sciences University of Sierra Leone...
January 4, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29298267/prior-generic-arthroscopic-volume-correlates-with-hip-arthroscopic-proficiency-a-simulator-study
#7
Gurhan Erturan, Abtin Alvand, Andrew Judge, Thomas C B Pollard, Sion Glyn-Jones, Jonathan L Rees
BACKGROUND: Changing trends in surgical education and patient expectation are leading to proficiency models of progression and the use of simulators. Hip arthroscopy is increasingly performed and has a steep learning curve mainly addressed during fellowship training. The aim of this study was to assess the impact of previous generic arthroscopic experience on performance at a simulated hip arthroscopy task to both estimate the minimum case numbers that correlate with expert proficiency levels and help to guide selection for hip arthroscopy fellowships...
January 3, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29287033/impact-of-new-medications-and-4-generic-programs-on-overactive-bladder-treatment-among-older-adults-in-the-united-states-2000-2015
#8
Alan C Kinlaw, Michele Jonsson Funk, Mitchell M Conover, Virginia Pate, Alayne D Markland, Jennifer M Wu
BACKGROUND: Despite several new medications being Food and Drug Administration-approved for overactive bladder (OAB) and new prescription drug payment programs, there are limited population-based data regarding OAB medication use among older adults. OBJECTIVES: To examine: (1) impacts of new medications and $4 generic programs on time trends for OAB-related medication dispensing for older adults in the United States; (2) differences by age and sex; and (3) temporal changes in OAB-related medication payments...
December 28, 2017: Medical Care
https://www.readbyqxmd.com/read/29283871/resources-for-educating-training-and-mentoring-all-physicians-providing-palliative-care
#9
James Downar
This article presents a rapid review of the published literature and available resources for educating Canadian physicians to provide palliative and end-of-life care. Several key messages emerge from the review. First, there are many palliative care educational resources already available for Canadian physicians. Second, the many palliative care education resources are often not used in physician training. Third, we know that some palliative care educational interventions are inexpensive and scalable, while others are costly and time-consuming; we know very little about which palliative care educational interventions impact physician behavior and patient care...
January 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29277111/the-value-of-motion-patient-reported-outcome-measures-are-correlated-with-range-of-motion-in-total-ankle-replacement
#10
Travis J Dekker, Kamran S Hamid, Andrew E Federer, John R Steele, Mark E Easley, James A Nunley, Samuel B Adams
BACKGROUND: The proposed benefit of total ankle replacement (TAR) over ankle fusion is preserved ankle motion, thus we hypothesized that an increase in range of motion (ROM) is positively correlated with validated patient-reported outcome measures (PROMs) in individuals receiving TAR. METHODS: Patients undergoing TAR at a single academic medical center between 2007 and 2013 were evaluated in this study. In addition to a minimum of 2-year follow-up, complete preoperative and postoperative outcome measures for the Foot and Ankle Disability Index (FADI), Short Musculoskeletal Function Assessment (SMFA) Bother and Function Indices, Visual Analog Scale (VAS), and 36-Item Short Form Health Survey (SF-36) were requisite for inclusion...
December 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29276071/enhancement-of-force-patterns-classification-based-on-gaussian-distributions
#11
Thomas Ertelt, Ilja Solomonovs, Thomas Gronwald
Description of the patterns of ground reaction force is a standard method in areas such as medicine, biomechanics and robotics. The fundamental parameter is the time course of the force, which is classified visually in particular in the field of clinical diagnostics. Here, the knowledge and experience of the diagnostician is relevant for its assessment. For an objective and valid discrimination of the ground reaction force pattern, a generic method, especially in the medical field, is absolutely necessary to describe the qualities of the time-course...
December 13, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29259169/systematic-screening-of-generic-drugs-for-progressive-multiple-sclerosis-identifies-clomipramine-as-a-promising-therapeutic
#12
Simon Faissner, Manoj Mishra, Deepak K Kaushik, Jianxiong Wang, Yan Fan, Claudia Silva, Gail Rauw, Luanne Metz, Marcus Koch, V Wee Yong
The treatment of progressive multiple sclerosis (MS) is unsatisfactory. One reason is that the drivers of disease, which include iron-mediated neurotoxicity, lymphocyte activity, and oxidative stress, are not simultaneously targeted. Here we present a systematic screen to identify generic, orally available medications that target features of progressive MS. Of 249 medications that cross the blood-brain barrier, 35 prevent iron-mediated neurotoxicity in culture. Of these, several antipsychotics and antidepressants strongly reduce T-cell proliferation and oxidative stress...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29238196/the-role-of-new-antidepressants-in-clinical-practice-in-canada-a-brief-review-of-vortioxetine-levomilnacipran-er-and-vilazodone
#13
REVIEW
Roger S McIntyre
Although many branded and generic antidepressants are approved for the treatment of major depressive disorder (MDD) in Canada, efficacy and tolerability differ among patients, and new treatment options are needed. Symptom types (eg, fatigue, energy/motivation, cognition, and functioning), medication type, treatment duration, and the need for maintenance therapy are factors that may influence treatment effectiveness. Three antidepressants, vortioxetine, levomilnacipran extended-release (ER), and vilazodone have recently become available in Canada...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29231234/feasibility-acceptability-and-effectiveness-of-integrated-care-for-copd-patients-a-mixed-methods-evaluation-of-a-pilot-community-based-programme
#14
Tania Carron, Pierre-Olivier Bridevaux, Karin Lörvall, Rachel Parmentier, Jean-Bernard Moix, Vincent Beytrison, Raymond Pernet, Constance Rey, Pierre-Yves Roberfroid, Prashant N Chhajed, Thomas Dieterle, Ladina Joos Zellweger, Malcolm Kohler, Sabrina Maier, David Miedinger, Robert Thurnheer, Pascal Urwyler, Jean-Marie Tschopp, Emilie Zuercher, Jörg Daniel Leuppi, Bernard Burnand, Isabelle Peytremann-Bridevaux
QUESTION UNDER STUDY: The aim of this study was to assess the feasibility, acceptability and effectiveness of a pilot COPD integrated care programme implemented in Valais, Switzerland. METHODS: The programme was adapted from the self-management programme Living Well with COPD, and included the following elements: self-management patient-education group sessions, telephone and medical follow-ups, multidisciplinary teams, training of healthcare professionals, and evidence-based COPD care...
December 12, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29224343/the-molecular-mechanism-of-nanodroplet-stability
#15
Evangelia Zdrali, Yixing Chen, Halil I Okur, David Mark Wilkins, Sylvie Roke
Mixtures of nano- and microscopic oil droplets in water have recently been rediscovered as miniature reaction vessels in microfluidic environments and are important constituents of many environmental systems, food, personal care and medical products. The oil nanodroplet/water interface stabilized by surfactants determines the physicochemical properties of the droplets. Surfactants are thought to stabilize nanodroplets by forming densely packed monolayers that shield the oil phase from the water. This idea has been inferred from droplet stability measurements in combination with molecular structural data obtained from extended planar interfaces...
December 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/29223434/durability-of-quality-of-life-benefits-of-transcatheter-aortic-valve-replacement-long-term-results-from-the-corevalve-us-extreme-risk-trial
#16
MULTICENTER STUDY
Suzanne J Baron, Suzanne V Arnold, Matthew R Reynolds, Kaijun Wang, Michael Deeb, Michael J Reardon, James Hermiller, Steven J Yakubov, David H Adams, Jeffrey J Popma, David J Cohen
BACKGROUND: For patients with severe aortic stenosis (AS) at extreme surgical risk, transcatheter aortic valve replacement (TAVR) leads to improved survival and health status when compared with medical therapy. Whether the early health status benefits of TAVR in these patients are sustained beyond 1 year of follow-up is unknown. METHODS AND RESULTS: Six hundred thirty-nine patients with severe AS at extreme surgical risk underwent TAVR in the CoreValve US Extreme Risk Pivotal trial...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29215311/classification-of-breast-cancer-from-ultrasound-imaging-using-a-generic-deep-learning-analysis-software-a-pilot-study
#17
Anton S Becker, Michael Mueller, Elina Stoffel, Magda Marcon, Soleen Ghafoor, Andreas Boss
PURPOSE: To train a generic deep learning software (DLS) to classify breast cancer on ultrasound images and to compare its performance to human readers with variable breast imaging experience. METHODS: In this IRB-approved, HIPAA compliant, retrospective study, all breast ultrasound examinations from January 1, 2014, to December 31, 2014 were reviewed. Patients with postsurgical scars, initially indeterminate, or malignant lesions with histological diagnoses or 2-year follow-up were included...
December 7, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29210313/pain-predicts-poorer-health-related-quality-of-life-in-childhood-onset-systemic-lupus-erythematosus-a-cohort-study
#18
Ji Li, Jordan T Jones, Catherine Donnelly, Natoshia Cunningham, Susmita Kashikar-Zuck, Hermine I Brunner
Objectives To investigate the predictive value of pain on health-related quality of life (HRQoL) among patients with childhood-onset systemic lupus erythematous (cSLE), as increased adverse psychosocial events are reported in patients with cSLE, but the predictive impact of psychological events on HRQoL remains unclear. Methods This cohort study recruited patients with cSLE from the Cincinnati Children's Hospital Medical Centre rheumatology clinic. Data regarding pain due to lupus in past week, and HRQoL, were collected during a baseline and 6-month follow-up visit...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29204784/long-term-quality-of-life-changes-after-primary-septorhinoplasty
#19
Olcay Cem Bulut, Frank Wallner, Dare Oladokun, Claire Kayser, Michaela Plath, Eric Schulz, Peter Karl Plinkert, Ingo Baumann
PURPOSE: Health-related quality of life measurements are gaining in importance in clinical medicine. Little is known about the long-term quality of life changes after septorhinoplasty. This study was designed to analyse the long-term quality of life impacts of septorhinoplasty, using disease-specific instruments-rhinoplasty outcome evaluation (ROE) and Functional Rhinoplasty Outcome Inventory-17 (FROI-17); as well as a generic instrument-Short-Form 36 Health Survey (SF-36). METHODS: Patients completed the FROI-17, the ROE and the SF-36 preoperatively and at 12 and 60 months postoperatively...
December 4, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29199634/optimism-and-quality-of-life-in-patients-with-heart-failure
#20
I H Kraai, K M Vermeulen, H L Hillege, T Jaarsma, T Hoekstra
OBJECTIVES: Health-related quality of life (HR-QoL) of patients with heart failure (HF) is low despite the aim of HF treatment to improve HR-QoL. To date, most studies have focused on medical and physical factors in relation to HR-QoL, few data are available on the role of emotional factors such as dispositional optimism. This study examines the prevalence of optimism and pessimism in HF patients and investigates how optimism and pessimism are associated with different patient characteristics and HR-QoL...
December 4, 2017: Palliative & Supportive Care
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