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https://www.readbyqxmd.com/read/27913012/hyperglycemic-high-anion-gap-metabolic-acidosis-in-patients-receiving-sglt-2-inhibitors-for-diabetes-management
#1
Juliette Sandifer Kum-Nji, Aidar R Gosmanov, Helmut Steinberg, Samuel Dagogo-Jack
Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) are a class of antidiabetic medications that improve glycemic control via inhibiting the reabsorption of filtered glucose and are approved for use in type 2 diabetes (T2DM). These drugs have recently been associated with euglycemic diabetic ketoacidosis (DKA). An increasing number of cases of SGLT-2i-associated DKA have occurred in patients with T2DM. Herein, we describe five episodes of hyperglycemic DKA in four type 2 diabetes patients receiving SGLT-2i therapy...
November 9, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27869610/electrolyte-and-metabolic-disturbances-in-ebola-patients-during-a-clinical-trial-guinea-2015
#2
Johan van Griensven, Elhadj Ibrahima Bah, Nyankoye Haba, Alexandre Delamou, Bienvenu Salim Camara, Kadio Jean-Jacques Olivier, Hilde De Clerck, Helena Nordenstedt, Malcolm G Semple, Michel Van Herp, Jozefien Buyze, Maaike De Crop, Steven Van Den Broucke, Lutgarde Lynen, Anja De Weggheleire
By using data from a 2015 clinical trial on Ebola convalescent-phase plasma in Guinea, we assessed the prevalence of electrolyte and metabolic abnormalities at admission and their predictive value to stratify patients into risk groups. Patients underwent testing with a point-of-care device. We used logistic regression to construct a prognostic model and summarized the predictive value with the area under the receiver operating curve. Abnormalities were common among patients, particularly hypokalemia, hypocalcemia, hyponatremia, raised creatinine, high anion gap, and anemia...
December 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27845368/magnetic-modes-in-rare-earth-perovskites-a-magnetic-field-dependent-inelastic-light-scattering-study
#3
Surajit Saha, Bing-Chen Cao, M Motapothula, Chun-Xiao Cong, Tarapada Sarkar, Amar Srivastava, Soumya Sarkar, Abhijeet Patra, Siddhartha Ghosh, Ariando, J M D Coey, Ting Yu, T Venkatesan
Here, we report the presence of defect-related states with magnetic degrees of freedom in crystals of LaAlO3 and several other rare-earth based perovskite oxides using inelastic light scattering (Raman spectroscopy) at low temperatures in applied magnetic fields of up to 9 T. Some of these states are at about 140 meV above the valence band maximum while others are mid-gap states at about 2.3 eV. No magnetic impurity could be detected in LaAlO3 by Proton-Induced X-ray Emission Spectroscopy. We, therefore, attribute the angular momentum-like states in LaAlO3 to cationic/anionic vacancies or anti-site defects...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27778049/geographic-location-is-an-important-determinant-of-risk-factors-for-stone-disease
#4
Ethan B Fram, Matthew D Sorensen, Vincent G Bird, Joshua M Stern
Some regions are known to have an increased burden of urolithiasis. Urolithiasis is known to be affected by weather patterns, particularly high ambient temperatures. To identify geographic differences in risk factors, we compared metabolic information for 1254 patients in two geographically distinct regions, New York and Florida, with per sample adjustment for ambient weather. We observed that patients in New York were more likely to have low urine volume, but also lower total urinary calcium (168 vs 216 mg, p = 0...
October 24, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27711644/probing-the-low-energy-structures-of-aluminum-magnesium-alloy-clusters-a-detailed-study
#5
Xiaodong Xing, Jingjing Wang, Xiaoyu Kuang, Xinxin Xia, Cheng Lu, George Maroulis
The effect of Mg doping on the growth behavior and the electronic properties of aluminum clusters has been investigated theoretically using the CALYPSO (Crystal structure AnaLYsis by Particle Swarm Optimization) method in combination with density functional theory calculations. Compared to pure aluminum clusters, the structure of Mg-doped clusters shows the charming transformation with increasing atomic number. The photoelectron spectra (PES) of the global minima of anionic Aln and AlnMg (n = 3-20) clusters have been calculated based on the time-dependent density functional theory (TD-DFT) method...
September 21, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27603707/electronic-structure-and-energy-transfer-in-europium-iii-ciprofloxacin-complexes-a-theoretical-study
#6
Tatiana B Emelina, Alexandra Ya Freidzon, Alexander A Bagaturyants, Vladimir E Karasev
The structure and ligand-localized excited states of [Eu(cfqH) (cfq)(H2O)4]Cl2 (cfqH is ciprofloxacin) are studied by XMCQDPT2/CASSCF with full geometry optimization. The complex includes one anionic and one zwitterionic ligand. Two low-lying triplet states, both localized on the anionic ligand, are found. One of them has sufficient energy to transfer to the (5)D1 sublevel of Eu(3+), because its T-S0 vertical transition energy is equal (or very close) to the (7)F0-(5)D1 Eu(3+) excitation energy. The other triplet state has a very small S0-T1 gap, which favors fast nonradiative relaxation...
September 29, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27600662/low-temperature-synthesis-of-bismuth-chalcohalides-candidate-photovoltaic-materials-with-easily-continuously-controllable-band-gap
#7
Hironobu Kunioku, Masanobu Higashi, Ryu Abe
Although bismuth chalcohalides, such as BiSI and BiSeI, have been recently attracting considerable attention as photovoltaic materials, the methods available to synthesize them are quite limited thus far. In this study, a novel, facile method to synthesize these chalcohalides, including BiSBr1-xIx solid solutions, at low temperatures was developed via the substitution of anions from O(2-) to S(2-) (or Se(2-)) using bismuth oxyhalide precursors. Complete phase transition was readily observed upon treatment of BiOI particles with H2S or H2Se at surprisingly low temperatures of less than 150 °C and short reaction times of less than 1 h, producing BiSI and BiSeI particles, respectively...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27582355/madelung-and-hubbard-interactions-in-polaron-band-model-of-doped-organic-semiconductors
#8
Rui-Qi Png, Mervin C Y Ang, Meng-How Teo, Kim-Kian Choo, Cindy Guanyu Tang, Dagmawi Belaineh, Lay-Lay Chua, Peter K H Ho
The standard polaron band model of doped organic semiconductors predicts that density-of-states shift into the π-π* gap to give a partially filled polaron band that pins the Fermi level. This picture neglects both Madelung and Hubbard interactions. Here we show using ultrahigh workfunction hole-doped model triarylamine-fluorene copolymers that Hubbard interaction strongly splits the singly-occupied molecular orbital from its empty counterpart, while Madelung (Coulomb) interactions with counter-anions and other carriers markedly shift energies of the frontier orbitals...
2016: Nature Communications
https://www.readbyqxmd.com/read/27577038/anion-gap-as-a-prognostic-tool-for-risk-stratification-in-critically-ill-patients-a-systematic-review-and-meta-analysis
#9
Stella Andrea Glasmacher, William Stones
BACKGROUND: Lactate concentration is a robust predictor of mortality but in many low resource settings facilities for its analysis are not available. Anion gap (AG), calculated from clinical chemistry results, is a marker of metabolic acidosis and may be more easily obtained in such settings. In this systematic review and meta-analysis we investigated whether the AG predicts mortality in adult patients admitted to critical care settings. METHODS: We searched Medline, Embase, Web of Science, Scopus, The Cochrane Library and regional electronic databases from inception until May 2016...
2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27576149/potential-aquifer-vulnerability-in-regions-down-gradient-from-uranium-in-situ-recovery-isr-sites
#10
REVIEW
James A Saunders, Bruce E Pivetz, Nathan Voorhies, Richard T Wilkin
Sandstone-hosted roll-front uranium ore deposits originate when U(VI) dissolved in groundwater is reduced and precipitated as insoluble U(IV) minerals. Groundwater redox geochemistry, aqueous complexation, and solute migration are important in leaching uranium from source rocks and transporting it in low concentrations to a chemical redox interface where it is deposited in an ore zone typically containing the uranium minerals uraninite, pitchblende, and/or coffinite; various iron sulfides; native selenium; clays; and calcite...
December 1, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27447868/copper-selenidophosphates-cu4p2se6-cu4p3se4-cu4p4se3-and-cup2se-featuring-zero-one-and-two-dimensional-anions
#11
Alexander Kuhn, Leslie M Schoop, Roland Eger, Igor Moudrakovski, Stefan Schwarzmüller, Viola Duppel, Reinhard K Kremer, Oliver Oeckler, Bettina V Lotsch
Five new compounds in the Cu/P/Se phase diagram have been synthesized, and their crystal structures have been determined. The crystal structures of these compounds comprise four previously unreported zero-, one-, and two-dimensional selenidophosphate anions containing low-valent phosphorus. In addition to two new modifications of Cu4P2Se6 featuring the well-known hexaselenidohypodiphosphate(IV) ion, there are three copper selenidophosphates with low-valent P: Cu4P3Se4 contains two different new anions, (i) a monomeric (zero-dimensional) selenidophosphate anion [P2Se4](4-) and (ii) a one-dimensional selenidophosphate anion [Formula: see text], which is related to the well-known gray-Se-like [Formula: see text] Zintl anion...
August 15, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27447787/real-time-urinary-electrolyte-monitoring-after-furosemide-administration-in-surgical-icu-patients-with-normal-renal-function
#12
Luca Zazzeron, Davide Ottolina, Eleonora Scotti, Michele Ferrari, Paola Bruzzone, Silvio Sibilla, Cristina Marenghi, Luciano Gattinoni, Pietro Caironi
BACKGROUND: Although the loop-diuretic furosemide is widely employed in critically ill patients with known long-term effects on plasma electrolytes, accurate data describing its acute effects on renal electrolyte handling and the generation of plasma electrolyte alterations are lacking. We hypothesized that the long-term effects of furosemide on plasma electrolytes and acid-base depend on its immediate effects on electrolyte excretion rate and patient clinical baseline characteristics...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27409637/respiratory-effects-of-sarafotoxins-from-the-venom-of-different-atractaspis-genus-snake-species
#13
Stéphanie Malaquin, Sam Bayat, Osama Abou Arab, Gilles Mourier, Emmanuel Lorne, Saïd Kamel, Hervé Dupont, Frédéric Ducancel, Yazine Mahjoub
Sarafotoxins (SRTX) are endothelin-like peptides extracted from the venom of snakes belonging to the Atractaspididae family. A recent in vivo study on anesthetized and ventilated animals showed that sarafotoxin-b (SRTX-b), extracted from the venom of Atractaspis engaddensis, decreases cardiac output by inducing left ventricular dysfunction while sarafotoxin-m (SRTX-m), extracted from the venom of Atractaspis microlepidota microlepidota, induces right ventricular dysfunction with increased airway pressure. The aim of the present experimental study was to compare the respiratory effects of SRTX-m and SRTX-b...
2016: Toxins
https://www.readbyqxmd.com/read/27369511/star-like-superalkali-cations-featuring-planar-pentacoordinate-carbon
#14
Jin-Chang Guo, Wen-Juan Tian, Ying-Jin Wang, Xue-Feng Zhao, Yan-Bo Wu, Hua-Jin Zhai, Si-Dian Li
Superalkali cations, known to possess low vertical electron affinities (VEAs), high vertical detachment energies, and large highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) energy gaps, are intriguing chemical species. Thermodynamically, such species need to be the global minima in order to serve as the promising targets for experimental realization. In this work, we propose the strategies of polyhalogenation and polyalkalination for designing the superalkali cations. By applying these strategies, the local-minimum planar pentacoordinate carbon (ppC) cluster CBe5 can be modified to form a series of star-like superalkali ppC or quasi-ppC CBe5X5 (+) (X = F, Cl, Br, Li, Na, K) cations containing a CBe5 moiety...
June 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27267918/hyperchloremia-why-and-how
#15
Glenn T Nagami
Hyperchloremia is a common electrolyte disorder that is associated with a diverse group of clinical conditions. The kidney plays an important role in the regulation of chloride concentration through a variety of transporters that are present along the nephron. Nevertheless, hyperchloremia can occur when water losses exceed sodium and chloride losses, when the capacity to handle excessive chloride is overwhelmed, or when the serum bicarbonate is low with a concomitant rise in chloride as occurs with a normal anion gap metabolic acidosis or respiratory alkalosis...
July 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27162696/postperfusion-lung-syndrome-and-related-sequelae
#16
Shi-Min Yuan
Postperfusion lung syndrome is a rare but sometimes lethal complication secondary to cardiopulmonary bypass. It often leads to multiorgan failure and mixed acid-base disturbances, thus making a refractory condition. A 69-year-old female, undergoing a successful cardiac lipoma resection under cardiopulmonary bypass, unfortunately developed postperfusion lung syndrome with associated multiorgan failure and triple acid-base disturbances (TABDs). Her condition deteriorated rapidly on postoperative day three and became moribund...
May 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27104913/fe-ii-spin-transition-materials-including-an-amino-ester-1-2-4-triazole-derivative-operating-at-below-and-above-room-temperature
#17
Marinela M Dîrtu, Anil D Naik, Aurelian Rotaru, Leonard Spinu, Dirk Poelman, Yann Garcia
A new family of one-dimensional Fe(II) 1,2,4-triazole spin transition coordination polymers for which a modification of anion and crystallization solvent can tune the switching temperature over a wide range, including the room temperature region, is reported. This series of materials was prepared as powders after reaction of ethyl-4H-1,2,4-triazol-4-yl-acetate (αEtGlytrz) with an iron salt from a MeOH/H2O medium affording: [Fe(αEtGlytrz)3](ClO4)2 (1); [Fe(αEtGlytrz)3](ClO4)2·CH3OH (2); [Fe(αEtGlytrz)3](NO3)2·H2O (3); [Fe(αEtGlytrz)3](NO3)2 (4); [Fe(αEtGlytrz)3](BF4)2·0...
May 2, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27073901/grapefruit-derived-flavonoid-naringin-improves-ketoacidosis-and-lipid-peroxidation-in-type-1-diabetes-rat-model
#18
Alfred N Murunga, David O Miruka, Christine Driver, Fezile S Nkomo, Snazo Z Z Cobongela, Peter M O Owira
BACKGROUND: Hypoglycemic effects of grapefruit juice are well known but the effects of naringin, its main flavonoid on glucose intolerance and metabolic complications in type 1 diabetes are not known. OBJECTIVES: To investigate the effects of naringin on glucose intolerance, oxidative stress and ketonemia in type 1 diabetic rats. METHODS: Sprague-Dawley rats divided into 5 groups (n = 7) were orally treated daily with 3.0 ml/kg body weight (BW)/day of distilled water (group 1) or 50 mg/kg BW of naringin (groups 2 and 4, respectively)...
2016: PloS One
https://www.readbyqxmd.com/read/26938517/photochemistry-of-the-%C3%AE-al%C3%A2-o%C3%A2-petn-interface
#19
Roman V Tsyshevsky, Anton Zverev, Anatoly Mitrofanov, Sergey N Rashkeev, Maija M Kuklja
Optical absorption measurements are combined with electronic structure calculations to explore photochemistry of an α-Al₂O₃-PETN interface formed by a nitroester (pentaerythritol tetranitrate, PETN, C₅H₈N₄O12) and a wide band gap aluminum oxide (α-Al₂O₃) substrate. The first principles modeling is used to deconstruct and interpret the α-Al₂O₃-PETN absorption spectrum that has distinct peaks attributed to surface F⁰-centers and surface-PETN transitions. We predict the low energy α-Al₂O₃ F⁰-center-PETN transition, producing the excited triplet state, and α-Al₂O₃ F⁰-center-PETN charge transfer, generating the PETN anion radical...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26917798/mind-the-gap-a-case-of-severe-methanol-intoxication
#20
Salik Nazir, Stephen Melnick, Shabana Ansari, Haitham T Kanneh
We report a case of a 37-year-old woman with non-insulin-dependent diabetes on sitagliptin, an alcohol abuser who was brought unresponsive to the emergency department of our hospital. On arrival, the patient was intubated and mechanically ventilated due to a low Glasgow Coma score of 3/15. Initial laboratory testing identified profound high anion gap metabolic acidosis. Owing to the dubious circumstances and the depth of acidosis, methanol and ethylene glycol intoxication was suspected. Further evaluation revealed a significantly increased serum osmolal gap...
2016: BMJ Case Reports
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