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Autoimmune progesterone dermatitis

Travis James, Jessica Ghaferi, Ann LaFond
INTRODUCTION: The histologic features of autoimmune progesterone dermatitis are generally non-specific and have only been described in brief case reports. We present a case of autoimmune progesterone dermatitis and review the literature with a focus on the histologic findings described. METHODS: A review of the English literature on autoimmune progesterone dermatitis was performed using PubMed and MEDLINE. RESULTS: 39 patients, including our patient are included in this review...
October 21, 2016: Journal of Cutaneous Pathology
Jillian Frieder, Mohammad Younus
No abstract text is available yet for this article.
October 2016: Annals of Allergy, Asthma & Immunology
Sara Camões, Joana Sampaio, Joana Rocha, Pedro Tiago, Cristina Lopes
Autoimmune progesterone dermatitis (APD) is a rare skin condition with a varying morphology, which appears on a monthly basis during the luteal phase of the menstrual cycle and resolves spontaneously with the endogenous decrease in progesterone during menses. We present the case of 39-year-old multiparous Caucasian woman with generalised, self-limited urticaria in her perimenstrual period. APD was diagnosed in light of the cyclical nature of the symptoms. An intradermal test with the administration of 0.5 mg/mL of medroxyprogesterone acetate showed a positive result...
August 4, 2016: Australasian Journal of Dermatology
Dinah Foer, Kathleen M Buchheit, Antonio Rosario Gargiulo, Donna Marie Lynch, Mariana Castells, Paige G Wickner
BACKGROUND: Autoimmune progesterone dermatitis is a poorly recognized syndrome associated with a hypersensitivity to progestogens. Symptoms present heterogeneously, which may complicate diagnosis. Management has generally centered on symptomatic control with medication. Recently, an increasing number of cases have been reported with in vitro fertilization (IVF). Desensitization to progestogens is suggested as an approach to tolerate fertility treatments and provide symptom control. OBJECTIVES: To describe the diagnosis and management of progestogen hypersensitivity (PH) and to detail the use of desensitization...
July 2016: Journal of Allergy and Clinical Immunology in Practice
John B Fournier
No abstract text is available yet for this article.
September 2015: JAAD Case Reports
Lumuli Mbonile
Autoimmune progesterone dermatitis (APD) is a rare autoimmune response to raised endogenous progesterone levels that occur during the luteal phase of the menstrual cycle. Cutaneous, mucosal lesions and other systemic manifestations develop cyclically during the luteal phase of the menstrual cycle when progesterone levels are elevated. APD symptoms usually start 3 - 10 days before menstruation and resolve 1 - 2 days after menstruation ceases. A 30-year-old woman presented with urticaria, petechiae and palpable pinpoint purpura lesions of the legs, forearms, neck and buttocks 1 week prior to her menses starting and 2 months after a medical abortion...
April 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Angela DeRosa, Shellee Adams, Erin Kathleen Fee
Autoimmune progesterone dermatitis (AIPD) is an uncommon condition in which allergic dermatitis to endogenous progesterone manifests in cyclic cutaneous eruptions. In this case series, we present 3 patients with AIPD, each with unique presentations and medical histories emblematic of the disease. Cyclic dermatitis related to menses in a premenopausal woman should raise high clinical suspicion for AIPD, especially in the primary care or emergency setting. Because of the rarity of this disorder, this case series seeks to describe AIPD to medical providers of young women, as well as present relevant literature related to the disease...
December 2015: Journal of the American Osteopathic Association
Tegan Nguyen, A Razzaque Ahmed
UNLABELLED: Autoimmune progesterone dermatitis (APD) is rare autoimmune hypersensitivity reaction to the fluctuations of endogenous progesterone during a woman's menstrual cycle. It has a wide spectrum of clinical presentations including urticaria, eczema and vesiculobullous eruptions. The disease course depends on treatment modality. The pathogenic mechanisms of APD remain to be elucidated. OBJECTIVE: We aim to review the literature on APD and evaluate the different theories of pathogenesis and treatments for this condition...
February 2016: Autoimmunity Reviews
Amy Domeyer-Klenske, Diana Robillard, John Pulvino, Daniel Spratt
BACKGROUND: Autoimmune progesterone dermatitis is a catamenial disorder traditionally diagnosed by subcutaneous or intramuscular progesterone challenge. Little has been reported regarding the use of a gonadotropin-releasing hormone (GnRH) agonist with a progestin add-back challenge to diagnose and guide management of this condition. CASE: A 50-year-old premenopausal woman presented with cyclic facial rash minimally responsive to standard treatment. Symptoms improved with depot leuprolide acetate and worsened with add-back progesterone therapy...
May 2015: Obstetrics and Gynecology
R S Raghunath, Z C Venables, G W M Millington
Perimenstrual exacerbations of dermatoses are commonly recognized, yet our knowledge of the underlying pathophysiological mechanisms remains imperfect. Research into the effects of oestrogen on the skin has provided evidence to suggest that oestrogen is associated with increases in skin thickness and dermal water content, improved barrier function, and enhanced wound healing. Research into the effects of progesterone suggests that the presence of various dermatoses correlates with peak levels of progesterone...
March 2015: Clinical and Experimental Dermatology
Ikbal Kaygusuz, Ilknur Inegol Gumus, Evren Sarifakioglu, Ayla Eser, Bulent Bozkurt, Hasan Kafali
No abstract text is available yet for this article.
September 2014: Taiwanese Journal of Obstetrics & Gynecology
R Verdolini, R Atkar, N Clayton, R Hasan, C M Stefanato
Catamenial dermatoses are unusual, cyclic, perimenstrual reactions to hormones produced during the menstrual cycle. They occur in a variety of clinical presentations, including urticaria, eczema, fixed drug eruptions, erythema multiforme and anaphylaxis. Autoimmune progesterone dermatitis is the most common, and is caused by an autoimmune response to endogenous progesterone in women of reproductive age. We report a case of catamenial dermatosis in a 42-year-old Jamaican woman with a 10-year history of cyclic blistering and ulcerative eruptions of her mouth and limbs...
June 2014: Clinical and Experimental Dermatology
Jennifer L Hill, Tara F Carr
No abstract text is available yet for this article.
September 2013: Journal of Allergy and Clinical Immunology in Practice
Trinh Hermanns-Lê, Jean-François Hermanns, Marianne Lesuisse, Gérald E Piérard
Circulating sex hormones follow major fluctuations during the ovarian cycle. The so-called premenstrual syndrome represents a global condition grouping the diversity of catamenial disorders. At the skin level, the sebaceous gland activity is obviously modulated by these endocrine fluctuations. In addition, a series of pathological manifestations take place simultaneously in some women. Among them, the most frequent skin condition is represented by catamenial acne. Concurrently, the autoimmune progesterone dermatitis refers to a diversity of skin alterations resulting from an immune reaction to progesterone...
2013: BioMed Research International
Z Lahmam Bennani, N El Fekih, D Baccouche, A Khaled, F Zaglaoui, B Fazaa
BACKGROUND: Autoimmune progesterone dermatitis (AIPD) is caused by an immune reaction to endogenous progesterone following exposure to exogenous progesterone, especially in oral contraceptives and intrauterine devices. Skin eruption develops cyclically during the luteal phase of the menstrual cycle when progesterone levels are elevated. The resultant clinical symptoms are frequently confused with other forms of dermatosis. We describe a young woman presenting AIPD. PATIENTS AND METHODS: A 23-year-old woman had a history of a chronic pruritic papular-vesicular eruption on the trunk, present since the onset of puberty and unsuccessfully treated with antihistamines and topical steroids...
December 2012: Annales de Dermatologie et de Vénéréologie
Rachana George, Shawky Z A Badawy
Background. Autoimmune progesterone dermatitis is a rare cyclic premenstrual allergic reaction to progesterone produced during the luteal phase of a woman's menstrual cycle. Patients present with a variety of conditions including erythema multiforme, eczema, urticaria, angioedema, and progesterone-induced anaphylaxis. Case. Thirty-eight-year-old woman G2P2002 presents with erythema multiforme and urticarial rash one week prior to her menses starting one year after menarche. She was treated with oral contraceptive pills and the symptoms resolved...
2012: Case Reports in Obstetrics and Gynecology
Justin P Bandino, John Thoppil, J Scott Kennedy, Chad M Hivnor
Preterm birth is the leading cause of perinatal morbidity and mortality in otherwise healthy infants, and the rate of pregnancies complicated by a premature delivery continues to rise. Subsequently, attempts have been made to reduce this rate by using progesterone supplementation during pregnancy. 17alpha-Hydroxyprogesterone caproate (17P), a metabolite of progesterone, also has been used as supplementation during pregnancy to prevent preterm births. We report a case of iatrogenic autoimmune progesterone dermatitis (APD) in a pregnant woman who received 17P therapy...
November 2011: Cutis; Cutaneous Medicine for the Practitioner
Katie Le, Glenda Wood
Autoimmune progesterone dermatitis is a rare, cyclical eruption that occurs in the luteal phase of the menstrual cycle and during pregnancy. Many manifestations have been reported including cyclical eczema, urticaria, erythema multiforme, stomatitis and even anaphylaxis. The condition spontaneously resolves after menopause. As histopathology is non-specific, the diagnosis rests on history with precipitation of the eruption by a progesterone challenge, usually by the intradermal, intramuscular or oral route...
May 2011: Australasian Journal of Dermatology
L M Toms-Whittle, L H John, D J Griffiths, D A Buckley
Autoimmune progesterone dermatitis (AIPD) is a rare, poorly characterized dermatosis, with about 60 previously reported cases. It typically undergoes cyclical flares relating to the menstrual cycle, especially the luteal phase, when levels of progesterone are at their highest. We report the case of a 34-year-old woman with an 8-year history of a profoundly pruritic eruption, associated with her menstrual cycle, in whom the diagnosis had proved elusive. Buserelin nasal spray resulted in complete clearance. AIPD is a diagnosis to consider in intractable eruptions in women, particularly if there is cyclical variation...
June 2011: Clinical and Experimental Dermatology
Myoung Kyu Lee, Won Yeon Lee, Suk Joong Yong, Kye Chul Shin, Shun Nyung Lee, Seok Jeong Lee, Ji-Ho Lee, Sang-Ha Kim
Autoimmune progesterone dermatitis is a rare autoimmune response to endogenous progesterone that usually occurs in fertile females. Cutaneous or mucosal lesions develop cyclically during the luteal phase of the menstrual cycle when progesterone levels are elevated. Symptoms usually start 3-10 days before menstruation and resolve 1-2 days after menstruation ceases. We report the case of a 48-year-old woman with intermittent eczematous skin lesions of the legs, forearms, and buttocks. She was diagnosed with allergic contact dermatitis, and topical steroids were prescribed...
April 2011: Allergy, Asthma & Immunology Research
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