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https://www.readbyqxmd.com/read/29688491/a-case-of-delayed-diagnosis-of-east-african-trypanosomiasis-in-a-dutch-traveller
#1
C A Wijsman, J L J Hanssen, H Scheper, L G Visser, L van Lieshout
We present a case of East-African trypanosomiasis (EAT) in a 56-year-old Dutch woman returning from holiday in Tanzania and Kenya. The diagnosis was delayed due to the lack of suspicion and secondly because of postponed analysis of blood microscopy after negative rapid malaria antigen testing. Second stage trypanosomiasis was ruled out with liquor analysis. She was treated first with pentamidine and shortly thereafter with suramin, after which she recovered. We emphasize the use of thin/thick smear diagnostics in travellers returning from endemic countries...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29686526/-alert-audit-act-assessment-of-surveillance-and-response-strategy-for-malaria-elimination-in-three-low-endemic-settings-of-myanmar-in-2016
#2
Aye Mon Mon Kyaw, Soundappan Kathirvel, Mrinalini Das, Badri Thapa, Nay Yi Yi Linn, Thae Maung Maung, Zaw Lin, Aung Thi
Background: Myanmar, a malaria endemic country of Southeast Asia, adopted surveillance and response strategy similar to "1-3-7" Chinese strategy to achieve sub-national elimination in six low-endemic region/states of the country. Among these, Yangon, Bago-East, and Mon region/states have implemented this malaria surveillance and response strategy with modification in 2016. The current study was conducted to assess the case notification, investigation, classification, and response strategy (NICR) in these three states...
2018: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29682411/pre-trained-convolutional-neural-networks-as-feature-extractors-toward-improved-malaria-parasite-detection-in-thin-blood-smear-images
#3
Sivaramakrishnan Rajaraman, Sameer K Antani, Mahdieh Poostchi, Kamolrat Silamut, Md A Hossain, Richard J Maude, Stefan Jaeger, George R Thoma
Malaria is a blood disease caused by the Plasmodium parasites transmitted through the bite of female Anopheles mosquito. Microscopists commonly examine thick and thin blood smears to diagnose disease and compute parasitemia. However, their accuracy depends on smear quality and expertise in classifying and counting parasitized and uninfected cells. Such an examination could be arduous for large-scale diagnoses resulting in poor quality. State-of-the-art image-analysis based computer-aided diagnosis (CADx) methods using machine learning (ML) techniques, applied to microscopic images of the smears using hand-engineered features demand expertise in analyzing morphological, textural, and positional variations of the region of interest (ROI)...
2018: PeerJ
https://www.readbyqxmd.com/read/29676064/machine-learning-based-in-line-holographic-sensing-of-unstained-malaria-infected-rbcs
#4
Taesik Go, Jun Ho Kim, Hyeokjun Byeon, Sang Joon Lee
Accurate and immediate diagnosis of malaria is important for medication of the infectious disease. Conventional methods for diagnosing malaria are time consuming and rely on the skill of experts. Therefore, an automatic and simple diagnostic modality is essential for healthcare in developing countries that lack the expertise of trained microscopists. In the present study, a new automatic sensing method using digital in-line holographic microscopy (DIHM) combined with machine learning algorithms was proposed to sensitively detect unstained malaria-infected red blood cells (RBCs)...
April 19, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29661231/surveillance-for-lymphatic-filariasis-after-stopping-mass-drug-administration-in-endemic-districts-of-togo-2010-2015
#5
Monique Ameyo Dorkenoo, Rachel Bronzan, Degninou Yehadji, Mawèke Tchalim, Kossi Yakpa, Santrao Etassoli, Poukpessi Adjeloh, Issaka Maman, Yao Sodahlon
BACKGROUND: Togo is a country previously endemic for lymphatic filariasis (LF). In 2010, following nine years of mass drug administration (MDA) for LF, the country established a post-treatment surveillance (PTS) system. We present here the results of these PTS activities, carried out from 2010 to 2015, as well as the findings of follow-up investigations in 2016 to confirm the absence of infection in previously infected individuals. METHODS: The routine surveillance established in 2010 consisted of a network of 47 laboratories, which searched for Wuchereria bancrofti microfilaria on nocturnal blood smears collected for malaria diagnosis and an additional network of 20 peripheral health facilities, which collected dried blood spots and tested them for Og4C3 antigen...
April 16, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29650008/the-challenge-of-maintaining-microscopist-capacity-at-basic-levels-for-malaria-elimination-in-jiangsu-province-china
#6
Guisheng Ding, Guoding Zhu, Caiqun Cao, Ping Miao, Yuanyuan Cao, Weiming Wang, Yaping Gu, Sui Xu, Shengqiang Wang, Huayun Zhou, Jun Cao
BACKGROUND: Local malaria transmission has decreased rapidly since the National Malaria Elimination Action Plan was launched in China in 2010. However, imported malaria cases from Africa and Southeast Asia still occur in China due to overseas laborers. Diagnosis by microscopy is the gold standard for malaria and is used in most hospitals in China. However, the current capacity of microscopists to manage malaria cases in hospitals and public health facilities to meet the surveillance needs to eliminate and prevent the reintroduction of malaria is unknown...
April 12, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29625787/tropical-diseases-in-the-icu-a-syndromic-approach-to-diagnosis-and-treatment
#7
Dilip R Karnad, Guy A Richards, Gisele Sampaio Silva, Pravin Amin
Tropical infections form 20-30% of ICU admissions in tropical countries. Diarrheal diseases, malaria, dengue, typhoid, rickettsial diseases and leptospirosis are common causes of critical illness. Overlapping clinical features makes initial diagnosis challenging. A systematic approach involving (1) history of specific continent or country of travel, (2) exposure to specific environments (forests or farms, water sports, consumption of exotic foods), (3) incubation period, and (4) pattern of organ involvement and subtle differences in manifestations help in differential diagnosis and choice of initial empiric therapy...
March 27, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29625586/a-17-year-trend-analysis-of-malaria-at-adi-arkay-north-gondar-zone-northwest-ethiopia
#8
Habtie Tesfa, Abebe Genetu Bayih, Ayalew Jejaw Zeleke
BACKGROUND: Malaria is one of the leading causes of death worldwide. This study aimed to determine the trend of malaria among febrile patients seeking treatment over 17 year (1997-2013) at Adi Arkay, Northwest Ethiopia. METHODS: A 17-year malaria microscopy data were extracted retrospectively at Adi Arkay health centre. Time series and curve estimation analysis were used to evaluate trends in the data. Pearson's Chi square test was also used to describe associations of variables...
April 6, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29623212/first-report-of-lyme-disease-in-nepal
#9
Sher Bahadur Pun, Sumit Agrawal, Santoshananda Jha, Lila Nath Bhandari, Bimal Sharma Chalise, Abadhesh Mishra, Rajesh Shah
Introduction: Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi and is widely reported in the USA, Central Europe, South East Asia and Latin America. Until recently, no scientific report regarding Lyme disease in Nepal had been published. Case presentation: A 32-year-old, previously healthy female visited the hospital with a history of joint pains, fatigue, neck stiffness, tingling sensation and headache. She was initially treated for typhoid fever, brucellosis and malaria, but did not show significant improvement...
March 2018: JMM Case Reports
https://www.readbyqxmd.com/read/29615059/local-knowledge-and-practices-towards-malaria-in-an-irrigated-farming-community-in-ghana
#10
Hector Attu, Jones K Adjei
BACKGROUND: Although malaria is endemic across Ghana, the risk is generally elevated for residents living in and around stagnant water bodies such as dams and irrigated farming projects. What knowledge do these at-risk populations have about the aetiology and symptoms of malaria? What are their coping strategies? And what interventions are needed to help improve the health outcomes of people living in high-risk malaria communities? METHODS: This study addressed these research questions with primary data, comprising both qualitative interviews and quantitative surveys, collected in Asutsuare-a rural irrigated farming community located in the Greater Accra Region of Ghana...
April 4, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29615041/school-based-malaria-prevalence-informative-systematic-surveillance-measure-to-assess-epidemiological-impact-of-malaria-control-interventions-in-the-democratic-republic-of-the-congo
#11
Edouard K Swana, Thierry I Yav, Leonard M Ngwej, Betty N Mupemba, Suprianto, Clarence K Mukeng, Izak Hattingh, Oscar N Luboya, Jean-Baptiste S Kakoma, Michael J Bangs
BACKGROUND: In southern Democratic Republic of the Congo, malaria transmission is stable with seasonal fluctuations. Different measurements can be used to monitor disease burden and estimate the performance of control programmes. Repeated school-based malaria prevalence surveys (SMPS) were conducted from 2007 to 2014 to generate up-to-date surveillance data and evaluate the impact of an integrated vector control programme. METHODS: Biannual SMPS used a stratified, randomized and proportional sampling method...
April 3, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29609602/streamlined-pcr-based-testing-for-pfhrp2-and-pfhrp3-negative-plasmodium-falciparum
#12
Jonathan B Parr, Olivia Anderson, Jonathan J Juliano, Steven R Meshnick
BACKGROUND: Rapid diagnostic tests (RDTs) that detect histidine-rich protein 2 (PfHRP2) are used throughout Africa for the diagnosis of Plasmodium falciparum malaria. However, recent reports indicate that parasites lacking the pfhrp2 and/or histidine-rich protein 3 (pfhrp3) genes, which produce antigens detected by these RDTs, are common in select regions of South America, Asia, and Africa. Proving the absence of a gene is challenging, and multiple PCR assays targeting these genes have been described...
April 2, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29582731/vector-borne-disease-is-a-common-cause-of-hospitalized-febrile-illness-in-india
#13
Matthew L Robinson, Dileep Kadam, Sandhya Khadse, Usha Balasubramanian, Priyanka Raichur, Chhaya Valvi, Ivan Marbaniang, Savita Kanade, Jonathan Sachs, Anita Basavaraj, Renu Bharadwaj, Anju Kagal, Vandana Kulkarni, Jonathan Zenilman, George Nelson, Yukari C Manabe, Aarti Kinikar, Amita Gupta, Vidya Mave
Acute febrile illness (AFI) is a major cause of morbidity and mortality in India and other resource-limited settings, yet systematic etiologic characterization of AFI has been limited. We prospectively enrolled adults ( N = 970) and children (age 6 months to 12 years, N = 755) admitted with fever from the community to Sassoon General Hospital in Pune, India, from July 2013 to December 2015. We systematically performed a standardized clinical history, clinical laboratories, and diagnostics. Results from additional testing ordered by treating clinicians were also recorded...
March 26, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29581051/febrile-illness-in-asia-gaps-in-epidemiology-diagnosis-management-for-informing-health-policy
#14
REVIEW
Poojan Shrestha, Tamalee Roberts, Anousin Homsana, Tin Ohn Myat, John A Crump, Yoel Lubell, Paul N Newton
BACKGROUND: There is increasing evidence on the aetiology and management of fevers in Asia, the importance of which has risen with declines in malaria incidence. AIMS: To conduct a narrative review of the epidemiology and management of fevers in South and South-East Asia and to highlight gaps in our knowledge that impair evidence-based health policy decisions. SOURCES: A narrative review of papers published since 2012 of developments in fever epidemiology, diagnosis and treatment in South and South-East Asia...
March 23, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29580244/simultaneous-detection-of-plasmodium-vivax-dhfr-dhps-mdr1-and-crt-o-resistance-associated-mutations-in-the-colombian-amazonian-region
#15
Juan Ricardo Cubides, Paola Andrea Camargo-Ayala, Carlos Hernando Niño, Diego Garzón-Ospina, Anggie Ortega-Ortegón, Estefany Ospina-Cantillo, María Fernanda Orduz-Durán, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo
BACKGROUND: Malaria continues being a public health problem worldwide. Plasmodium vivax is the species causing the largest number of cases of malaria in Asia and South America. Due to the lack of a completely effective anti-malarial vaccine, controlling this disease has been based on transmission vector management, rapid diagnosis and suitable treatment. However, parasite resistance to anti-malarial drugs has become a major yet-to-be-overcome challenge. This study was thus aimed at determining pvmdr1, pvdhfr, pvdhps and pvcrt-o gene mutations and haplotypes from field samples obtained from an endemic area in the Colombian Amazonian region...
March 27, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29579313/sickle-cell-disease-in-southwestern-nigeria-assessment-of-knowledge-of-primary-health-care-workers-and-available-facilities
#16
Samuel A Adegoke, Morenike A Akinlosotu, Olaronke B Adediji, Oyeku A Oyelami, Oluwagbemiga O Adeodu, Adekunle D Adekile
Background: Patients with sickle cell disease (SCD) benefit optimally from comprehensive care. In Nigeria, despite the huge burden, involvement of community health workers (CHWs) in the management of SCD is poor. Methods: This community-based study assessed SCD-related knowledge of 182 CHWs from the 46 primary health care (PHC) centres in Ilesa, southwestern Nigeria. Available facilities and management practices for SCD care at these centres were also evaluated using pretested self-administered questionnaires and observational checklists...
March 22, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29578406/neurovascular-sequestration-in-paediatric-p-falciparum-malaria-is-visible-clinically-in-the-retina
#17
Valentina Barrera, Ian Jc MacCormick, Gabriela Czanner, Paul Stephenson Hiscott, Valerie Ann White, Alister G Craig, Nicholas Alexander Venton Beare, Lucy Hazel Culshaw, Yalin Zheng, Simon Charles Biddolph, Danny A Milner, Steve Kamiza, Malcolm E Molyneux, Terrie E Taylor, Simon Peter Harding
Retinal vessel changes and retinal whitening, distinctive features of malarial retinopathy, can be directly observed during routine eye examination in children with P.falciparum cerebral malaria. We investigated their clinical significance and underlying mechanisms through linked clinical, clinicopathological and image analysis studies. Orange vessels and severe foveal whitening (clinical examination, n=817, OR, 95% CI: 2.90, 1.96-4.30; 3.4, 1.8-6.3, both p<0.001), and arteriolar involvement by intravascular filling defects (angiographic image analysis, n=260, 2...
March 26, 2018: ELife
https://www.readbyqxmd.com/read/29574241/acute-disseminated-encephalomyelitis-a-rare-post-malaria-neurological-complication-case-report-and-review-of-the-literature
#18
REVIEW
Joana Carreira, Maria Isabel Casella, Bianca Branco Ascenção, Nuno Pinto Luis, Ana Catarina Gonçalves, Ana Paula Brito, Joana Estalagem Sá, Mário Parreira, Delfim Lopes, José Poças
There are four neurological complications that can occur after malaria treatment at a time when the patient is aparasitaemic: delayed cerebellar ataxia, acute inflammatory demyelinating polyneuropathy, post-malaria neurological syndrome and acute disseminated encephalomyelitis (ADEM). The authors describe a case of a 54-year-old male who presented with encephalopathy and generalized seizures forty-three days after complete recovery from acute malaria by Plasmodium falciparum. Diagnosis of post-malaria ADEM was made based on the acute onset of the neurological symptoms, characteristic findings in magnetic resonance imaging of the brain and prompt response to steroid therapy...
March 21, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29567888/prevalence-of-scrub-typhus-in-pyrexia-of-unknown-origin-and-assessment-of-interleukin-8-tumor-necrosis-factor-alpha-and-interferon-gamma-levels-in-scrub-typhus-positive-patients
#19
Meher Rizvi, Asfia Sultan, Madhav Chowdhry, Mohd Azam, Fatima Khan, Indu Shukla, Haris M Khan
Background: Scrub typhus is lesser known cause of fever of unknown origin in India. Even if there have been reports documenting the prevalence of scrub typhus in different parts of India, it is still an unknown entity, and clinicians usually do not consider it as differential diagnosis. The present study was performed to document the prevalence of scrub typhus among febrile patients in western part of Uttar Pradesh and to assess the clinical profile of infected patients on the one hand and knowledge, attitude, and practices among clinicians on the other...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29565981/malaria-diagnosis-by-pcr-revealed-differential-distribution-of-mono-and-mixed-species-infections-by-plasmodium-falciparum-and-p-vivax-in-india
#20
Nisha Siwal, Upasana Shyamsunder Singh, Manoswini Dash, Sonalika Kar, Swati Rani, Charu Rawal, Rajkumar Singh, Anupkumar R Anvikar, Veena Pande, Aparup Das
Malaria is a vector-borne infectious disease, caused by five different species of the genus Plasmodium, and is endemic to many tropical and sub-tropical countries of the globe. At present, malaria diagnosis at the primary health care level in India is conducted by either microscopy or rapid diagnostic test (RDT). In recent years, molecular diagnosis (by PCR assay), has emerged as the most sensitive method for malaria diagnosis. India is highly endemic to malaria and shoulders the burden of two major malaria parasites, Plasmodium falciparum and P...
2018: PloS One
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