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https://www.readbyqxmd.com/read/28332579/corrigendum-towards-ultrasensitive-malaria-diagnosis-using-surface-enhanced-raman-spectroscopy
#1
Keren Chen, Clement Yuen, Yaw Aniweh, Peter Preiser, Quan Liu
No abstract text is available yet for this article.
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28329034/use-of-pfhrp2-only-rdts-rapidly-select-for-pfhrp2-negative-parasites-with-serious-implications-for-malaria-case-management-and-control
#2
Michelle L Gatton, Jessica Dunn, Alisha Chaudhry, Sadmir Ciketic, Jane Cunningham, Qin Cheng
Background: Rapid diagnostic tests (RDTs) are an important tool for malaria diagnosis, with most utilising antibodies against histidine-rich protein 2 (PfHRP2). Reports of Plasmodium falciparum lacking this protein are increasing, creating a problem for diagnosis of falciparum malaria in locations without quality microscopy. Methods: An agent-based stochastic simulation model of P.falciparum transmission was used to investigate the selective pressure exerted on parasite populations by use of RDTs for diagnosis of symptomatic cases...
March 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28321277/clinical-outcomes-among-febrile-children-aged-2-to-59-months-with-negative-malaria-rapid-diagnostic-test-results-in-mchinji-district-malawi
#3
Dyson Mwandama, Chawanangwa Mwale, Andrew Bauleni, Themba Phiri, Joseph Chisaka, Humphreys Nsona, Don P Mathanga
BACKGROUND: Malawi malaria treatment guidelines recommend a definitive diagnosis, using a malaria rapid diagnostic test (mRDT), for all patients with fever or history of fever. Improving the management and outcomes of febrile children with negative mRDT results should be a priority. METHODS: Through a prospective cohort study designed to investigate clinical outcomes of children treated at the community level, we followed, for 7 days, children aged 2 to 59 months, who had negative mRDT results and were treated with antipyretic medication...
December 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28320390/false-negative-malaria-rapid-diagnostic-tests-in-rwanda-impact-of-plasmodium-falciparum-isolates-lacking-hrp2-and-declining-malaria-transmission
#4
Christina T Kozycki, Noella Umulisa, Stephen Rulisa, Emil I Mwikarago, Jean Pierre Musabyimana, Jean Pierre Habimana, Corine Karema, Donald J Krogstad
BACKGROUND: Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a deletion of the hrp2 gene yield false-negative RDTs and there are concerns the sensitivity of HRP2-based RDTs may fall when the intensity of transmission decreases. METHODS: This observational study enrolled 9226 patients at three health centres in Rwanda from April 2014 to April 2015...
March 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28306518/biochemical-testing-in-a-laboratory-tent-and-semi-intensive-care-of-ebola-patients-on-site-in-a-remote-part-of-guinea-a-paradigm-shift-based-on-a-bleach-sensitive-point-of-care-device
#5
Leonid M Irenge, Jean-Michel Dindart, Jean-Luc Gala
BACKGROUND: During the West Africa Ebola virus disease (EVD) outbreak, a Belgian laboratory was deployed for supporting the Ebola treatment unit (ETU) of N'Zerekore, Guinea. Besides diagnosis of EVD and malaria, biochemical parameters were tested and used to guide supportive treatment of EVD. METHODS: To preserve analytes stability, lithium-heparin blood samples were analyzed using the i-STAT® point-of-care testing (POCT) handheld device without the viral inactivation step...
March 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28302168/comparison-of-the-diagnostic-performance-of-microscopic-examination-with-nested-polymerase-chain-reaction-for-optimum-malaria-diagnosis-in-upper-myanmar
#6
Jung-Mi Kang, Pyo-Yun Cho, Mya Moe, Jinyoung Lee, Hojong Jun, Hyeong-Woo Lee, Seong Kyu Ahn, Tae Im Kim, Jhang Ho Pak, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim, Byoung-Kuk Na
BACKGROUND: Accurate diagnosis of Plasmodium infection is crucial for prompt malaria treatment and surveillance. Microscopic examination has been widely applied as the gold standard for malaria diagnosis in most part of malaria endemic areas, but its diagnostic value has been questioned, particularly in submicroscopic malaria. In this study, the diagnostic performance of microscopic examination and nested polymerase chain reaction (PCR) was evaluated to establish optimal malaria diagnosis method in Myanmar...
March 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28301474/histidine-rich-protein-2-pfhrp2-and-pfhrp3-gene-deletions-in-plasmodium-falciparum-isolates-from-select-sites-in-brazil-and-bolivia
#7
Giselle Maria Rachid Viana, Sheila Akinyi Okoth, Luciana Silva-Flannery, Danielle Regina Lima Barbosa, Alexandre Macedo de Oliveira, Ira F Goldman, Lindsay C Morton, Curtis Huber, Arletta Anez, Ricardo Luiz Dantas Machado, Luís Marcelo Aranha Camargo, Suiane Costa Negreiros do Valle, Marinete Marins Póvoa, Venkatachalam Udhayakumar, John W Barnwell
More than 80% of available malaria rapid diagnostic tests (RDTs) are based on the detection of histidine-rich protein-2 (PfHRP2) for diagnosis of Plasmodium falciparum malaria. Recent studies have shown the genes that code for this protein and its paralog, histidine-rich protein-3 (PfHRP3), are absent in parasites from the Peruvian Amazon Basin. Lack of PfHRP2 protein through deletion of the pfhrp2 gene leads to false-negative RDT results for P. falciparum. We have evaluated the extent of pfhrp2 and pfhrp3 gene deletions in a convenience sample of 198 isolates from six sites in three states across the Brazilian Amazon Basin (Acre, Rondonia and Para) and 25 isolates from two sites in Bolivia collected at different times between 2010 and 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28295179/platelets-and-infections-in-the-resource-limited-countries-with-a-focus-on-malaria-and-viral-haemorrhagic-fevers
#8
REVIEW
Jecko Thachil
Infections continue to cause a high incidence of mortality and morbidity in resource-poor nations. Although antimicrobial therapy has aided mostly in dealing with the pathogenic micro-organisms themselves, the collateral damage caused by the infections continue to cause many deaths. Intensive care support and manipulation of the hosts' abnormal response to the infection have helped to improve mortality in well-resourced countries. But, in those areas with limited resources, this is not yet the case and simpler methods of diagnosis and interventions are required...
March 14, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28293411/a-strange-manifestation-of-malaria-in-a-native-nigerian-boy
#9
Paola Magro, Ilaria Izzo, Barbara Saccani, Salvatore Casari, Silvio Caligaris, Lina Rachele Tomasoni, Alberto Matteelli, Annamaria Lombardi, Antonella Meini, Francesco Castelli
The protective role of Sickle Cell Trait (SCT) in malaria endemic areas has been proved, and prevalence of HbS gene in malaria endemic areas is high. Splenic infarction is a well-known complication of SCT, while the association with malaria is considered rare. A Nigerian boy was admitted to our ward after returning from his country of origin, for P. falciparum malaria. He underwent abdominal ultrasound for upper right abdominal pain, showing cholecystitis and multiple splenic lesions suggestive of abscesses...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28291501/lateral-flow-rapid-test-for-accurate-and-early-diagnosis-of-scrub-typhus-a-febrile-illness-of-historically-military-importance-in-the-pacific-rim
#10
Chien-Chung Chao, Zhiwen Zhangm, Giulia Weissenberger, Hua-Wei Chen, Wei-Mei Ching
Scrub typhus (ST) is an infection caused by Orientia tsutsugamushi. Historically, ST was ranked as the second most important arthropod-borne medical problem only behind malaria during World War II and the Vietnam War. The disease occurs mainly in Southeast Asia and has been shown to emerge and reemerge in new areas, implying the increased risk for U.S. military and civilian personnel deployed to these regions. ST can effectively be treated by doxycycline provided the diagnosis is made early, before the development of severe complications...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28286460/lipid-response-patterns-in-acute-phase-paediatric-plasmodium-falciparum-malaria
#11
Judy Orikiiriza, Izabella Surowiec, Elisabeth Lindquist, Mari Bonde, Jimmy Magambo, Charles Muhinda, Sven Bergström, Johan Trygg, Johan Normark
INTRODUCTION: Several studies have observed serum lipid changes during malaria infection in humans. All of them were focused at analysis of lipoproteins, not specific lipid molecules. The aim of our study was to identify novel patterns of lipid species in malaria infected patients using lipidomics profiling, to enhance diagnosis of malaria and to evaluate biochemical pathways activated during parasite infection. METHODS: Using a multivariate characterization approach, 60 samples were representatively selected, 20 from each category (mild, severe and controls) of the 690 study participants between age of 0...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28279619/led-fluorescence-microscopy-novel-method-for-malaria-diagnosis-compared-with-routine-methods
#12
Riddhi Hathiwala, Preeti R Mehta, Gita Nataraj, Siddhi Hathiwala
Rapid and accurate diagnosis of malaria is the need of hour for effective management and controlling drug resistance. The conventional and gold-standard method, Light microscopy (LM), is time-consuming, requires trained staff and well-maintained equipments. The newly developed, rapid diagnostic tests (RDT) are fast and reliable, but give only qualitative results, are expensive and have short shelf life. Light Emission Diode fluorescence microscopy (LED FM) may provide a reliable alternative which can be used for routine diagnosis...
March 6, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28278416/arboviral-diseases-and-malaria-in-australia-2013-14-annual-report-of-the-national-arbovirus-and-malaria-advisory-committee
#13
Katrina E Knope, Mike Muller, Nina Kurucz, Stephen L Doggett, Rebecca Feldman, Cheryl A Johansen, Michaela Hobby, Sonya Bennett, Stacey Lynch, Angus Sly, Bart J Currie
This report describes the epidemiology of mosquito-borne diseases of public health importance in Australia during the 2013-14 season (1 July 2013 to 30 June 2014) and includes data from human notifications, sentinel chicken, vector and virus surveillance programs. The National Notifiable Diseases Surveillance System received notifications for 8,898 cases of disease transmitted by mosquitoes during the 2013-14 season. The Australasian alphaviruses Barmah Forest virus and Ross River virus accounted for 6,372 (72%) total notifications...
September 30, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28275077/improving-the-specificity-of-p-falciparum-malaria-diagnosis-in-high-transmission-settings-with-a-two-step-rdt-and-microscopy-algorithm
#14
Moses Murungi, Travis Fulton, Raquel Reyes, Michael Matte, Moses Ntaro, Edgar Mulogo, Dan Nyehangane, Jonathan J Juliano, Mark J Siedner, Yap Boum, Ross M Boyce
Poor specificity may negatively impact rapid diagnostic test (RDT) based diagnostic strategies for malaria. We performed real time polymerase chain reaction on a subset of subjects who had undergone diagnostic testing with a multiple antigen (HRP2/pLDH) RDT and microscopy. We determined the sensitivity and specificity of the RDT in comparison to PCR for the detection of P. falciparum malaria. We developed and evaluated a two-step algorithm utilizing the multiple-antigen RDT to screen patients followed by confirmatory microscopy for those individuals with HRP2+/pLDH- results...
March 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28274257/prevalence-and-determinants-of-malaria-among-children-in-zamb%C3%A3-zia-province-mozambique
#15
James G Carlucci, Meridith Blevins Peratikos, Charlotte B Cherry, Melanie L Lopez, Ann F Green, Lazaro González-Calvo, Troy D Moon
BACKGROUND: Malaria is the leading cause of death among children in Mozambique. Prevalence and factors associated with malaria are not well studied among children in rural Zambézia Province. Whether prevalence of malaria varies across diverse districts within the province is unknown. METHODS: A cross-sectional survey of female heads of household was conducted during April and May 2014, a period of peak malaria transmission. Data were collected on up to two randomly selected children aged 6-59 months per household...
March 9, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28269157/image-classification-of-unlabeled-malaria-parasites-in-red-blood-cells
#16
Zheng Zhang, L L Sharon Ong, Kong Fang, Athul Matthew, Justin Dauwels, Ming Dao, Harry Asada
This paper presents a method to detect unlabeled malaria parasites in red blood cells. The current "gold standard" for malaria diagnosis is microscopic examination of thick blood smear, a time consuming process requiring extensive training. Our goal is to develop an automate process to identify malaria infected red blood cells. Major issues in automated analysis of microscopy images of unstained blood smears include overlapping cells and oddly shaped cells. Our approach creates robust templates to detect infected and uninfected red cells...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267076/antimalarial-prescription-in-a-public-hospital-outpatient-setting-in-kenya-a-best-practice-implementation-project
#17
Henry K Amdany, Mark McMillan, Peninah Kiptoo
BACKGROUND: Important gaps still exist in malaria case management despite implementation of the World Health Organization parasitological diagnosis before treatment recommendation. This calls for evidence-based strategies to improve health providers' adherence to these guidelines. OBJECTIVE: The goal of this project was to improve adherence of confirmed parasitological diagnosis prior to antimalarial prescription in the outpatient department. METHODS: The Joanna Briggs Institute Practical Application of Clinical Evidence System program was used to facilitate collection of baseline and post-audit data...
March 2017: International Journal of Evidence-based Healthcare
https://www.readbyqxmd.com/read/28264678/passive-case-detection-of-malaria-in-ratanakiri-province-cambodia-to-detect-villages-at-higher-risk-for-malaria
#18
Somony Heng, Lies Durnez, Sokny Mao, Sovannaroth Siv, Sochantha Tho, Vanna Mean, Vincent Sluydts, Marc Coosemans
BACKGROUND: Cambodia reduced malaria incidence by more than 75% between 2000 and 2015, a target of the Millennium Development Goal 6. The Cambodian Government aims to eliminate all forms of malaria by 2025. The country's malaria incidence is highly variable at provincial level, but less is known at village level. This study used passive case detection (PCD) data at village level in Ratanakiri Province from 2010 to 2014 to describe incidence trends and identify high-risk areas of malaria to be primarily targeted towards malaria elimination...
March 6, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28263883/asymptomatic-plasmodium-malariae-infections-in-children-from-suburban-areas-of-yaound%C3%A3-cameroon
#19
Dongang Nana Rodrigue Roman, Ngono Ngane Annie Rosalie, Amit Kumar, Koanga Mogtomo Martin Luther, Vineeta Singh, Mouelle Sone Albert
The gold standard for malaria diagnosis is the microscopic examination of Giemsa stained thick blood smears though microscopy mostly may not detect the presence of Plasmodium species infections in asymptomatic samples. In the reported study, we used two diagnostic methods viz. the conventional microscopic examination and polymerase chain reaction (PCR) assay to analyse the asymptomatic malaria samples. PCR assay amplifying 18S small-subunit ribosomal RNA (SSU rRNA) gene of Plasmodium in 122 samples confirmed 68% of isolates as asymptomatic P...
March 2, 2017: Parasitology International
https://www.readbyqxmd.com/read/28259152/should-chemoprophylaxis-be-a-main-strategy-for-preventing-re-introduction-of-malaria-in-highly-receptive-areas-sri-lanka-a-case-in-point
#20
A Rajitha Wickremasinghe, Renu Wickremasinghe, Hemantha D B Herath, S Deepika Fernando
BACKGROUND: Imported malaria cases continue to be reported in Sri Lanka, which was declared 'malaria-free' by the World Health Organization in September 2016. Chemoprophylaxis, a recommended strategy for malaria prevention for visitors travelling to malaria-endemic countries from Sri Lanka is available free of charge. The strategy of providing chemoprophylaxis to visitors to a neighbouring malaria-endemic country within the perspective of a country that has successfully eliminated malaria but is highly receptive was assessed, taking Sri Lanka as a case in point...
March 4, 2017: Malaria Journal
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