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https://www.readbyqxmd.com/read/29454844/the-epidemiology-of-febrile-illness-in-sub-saharan-africa-implications-for-diagnosis-and-management
#1
REVIEW
Michael J Maze, Quique Bassat, Nicholas A Feasey, Inácio Mandomando, Patrick Musicha, John A Crump
BACKGROUND: Fever is among the most common symptoms of people living in Africa, and clinicians are challenged by the similar clinical features of a wide spectrum of potential aetiologies. AIM: To summarise recent studies of fever aetiology in sub-Saharan Africa focusing on causes other than malaria. SOURCES: A narrative literature review by searching the MEDLINE database, and recent conference abstracts. CONTENT: Studies of multiple potential causes of fever are scarce, and for many participants the infecting organism remains unidentified, or multiple co-infecting microorganisms are identified, and establishing causation is challenging...
February 15, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29445365/-babesia-microti-infection-changes-host-spleen-architecture-and-is-cleared-by-a-th1-immune-response
#2
Vitomir Djokic, Lavoisier Akoolo, Nikhat Parveen
Babesia microti is a malaria-like parasite, which infects ∼2000 people annually, such that babesiosis is now a notifiable disease in the United States. Immunocompetent individuals often remain asymptomatic and are tested only after they feel ill. Susceptible C3H/HeJ mice show several human-like disease manifestations and are ideal to study pathogenesis of Babesia species. In this study, we examined parasitemia of B. microti at different time points and assessed its impact on hemoglobin levels in blood, on spleen pathology and overall immune response in C3H/HeJ mice...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29426330/molecular-evidence-for-relapse-of-an-imported-plasmodium-ovale-wallikeri-infection
#3
Luzia Veletzky, Mirjam Groger, Heimo Lagler, Julia Walochnik, Herbert Auer, Hans-Peter Fuehrer, Michael Ramharter
BACKGROUND: Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce. CASE PRESENTATION: Here, the case of a 16-year-old male, who presented with fevers to the outpatient department in Vienna, Austria, after travelling to Uganda and Papua New Guinea is described...
February 9, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29419781/recent-advances-of-malaria-parasites-detection-systems-based-on-mathematical-morphology
#4
REVIEW
Andrea Loddo, Cecilia Di Ruberto, Michel Kocher
Malaria is an epidemic health disease and a rapid, accurate diagnosis is necessary for proper intervention. Generally, pathologists visually examine blood stained slides for malaria diagnosis. Nevertheless, this kind of visual inspection is subjective, error-prone and time-consuming. In order to overcome the issues, numerous methods of automatic malaria diagnosis have been proposed so far. In particular, many researchers have used mathematical morphology as a powerful tool for computer aided malaria detection and classification...
February 8, 2018: Sensors
https://www.readbyqxmd.com/read/29415724/improvement-of-malaria-diagnostic-system-based-on-acridine-orange-staining
#5
Masatsugu Kimura, Isao Teramoto, Chim W Chan, Zulkarnain Md Idris, James Kongere, Wataru Kagaya, Fumihiko Kawamoto, Ryoko Asada, Rie Isozumi, Akira Kaneko
BACKGROUND: Rapid diagnosis of malaria using acridine orange (AO) staining and a light microscope with a halogen lamp and interference filter was deployed in some malaria-endemic countries. However, it has not been widely adopted because: (1) the lamp was weak as an excitation light and the set-up did not work well under unstable power supply; and, (2) the staining of samples was frequently inconsistent. METHODS: The halogen lamp was replaced by a low-cost, blue light-emitting diode (LED) lamp...
February 7, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29415208/breathprinting-reveals-malaria-associated-biomarkers-and-mosquito-attractants
#6
Chad L Schaber, Nalin Katta, Lucy B Bollinger, Mwawi Mwale, Rachel Mlotha-Mitole, Indi Trehan, Barani Raman, Audrey R Odom John
Current evidence suggests that malaria infection could alter patient breath metabolites, a phenomenon that could be exploited to create a breath-based diagnostic test. However, no study has explored this in a clinical setting. To investigate whether natural human malaria infection leads to a characteristic breath profile, we performed a field study in Malawi. Breath volatiles from children with and without uncomplicated falciparum malaria were analyzed by thermal desorption-gas chromatography/mass spectrometry...
February 3, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29414182/laboratory-findings-in-zika-infection-the-experience-of-a-reference-centre-in-north-west-italy
#7
Elisa Burdino, Maria Grazia Milia, Tiziano Allice, Gabriella Gregori, Tina Ruggiero, Guido Calleri, Filippo Lipani, Anna Lucchini, Giulietta Venturi, Giovanni Di Perri, Valeria Ghisetti
BACKGROUND: Zika virus (ZIKV) remains a public health concern due to its association with fetal malformation and neurologic disease. OBJECTIVE: To report a reference centre experience on ZIKA virus (ZIKV) infection in travelers from epidemic countries from January 1 to September, 30, 2016 in Italy North-West (a geographic area covering 4.424 million inhabitants, corresponding to almost 73% of Italy North-West area). STUDY DESIGN: One hundred and twelve febrile travelers were studied to rule out a tropical fever [e...
January 30, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29412944/advances-in-biosensors-and-optical-assays-for-diagnosis-and-detection-of-malaria
#8
REVIEW
K V Ragavan, Sanni Kumar, Shiva Swaraj, Suresh Neethirajan
Vector-borne diseases are a major concern for human health globally, especially malaria in densely populated, less developed, tropical regions of the world. Malaria causes loss of human life and economic harm, and may spread through travelers to new regions. Though there are sufficient therapeutics available for the effective treatment and cure of malaria, it infects millions of people and claims several thousand lives every year. Early diagnosis of the infection can potentially prevent the spread of disease, save lives, and mitigate the financial impact...
May 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29409502/private-sector-malaria-rdt-initiative-in-nigeria-lessons-from-an-end-of-project-stakeholder-engagement-meeting
#9
Babatunde Odugbemi, Chijioke Ezeudu, Anyiekere Ekanem, Maxwell Kolawole, Idowu Akanmu, Aderemi Olawole, Nkabono Nglass, Chinwe Nze, Edward Idenu, Bala Mohammed Audu, Godwin Ntadom, Wondimagegnehu Alemu, Rex Mpazanje, Jane Cunningham, Augustine Akubue, Tolu Arowolo, Seye Babatunde
The malaria rapid diagnosis testing (RDT) landscape is rapidly evolving in health care delivery in Nigeria with many stakeholders playing or having potential for critical roles. A recent UNITAID grant supported a pilot project on the deployment of quality-assured RDTs among formal and informal private service outlets in three states in Nigeria. This paper describes findings from a series of stakeholder engagement meetings held at the conclusion of the project. The agreed meeting structure was a combination of plenary presentations, structured facilitated discussions, and nominal group techniques to achieve consensus...
February 6, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29408951/malaria-coinfections-in-febrile-pediatric-inpatients-a-hospital-based-study-from-ghana
#10
Benedikt Hogan, Daniel Eibach, Ralf Krumkamp, Nimako Sarpong, Denise Dekker, Benno Kreuels, Oumou Maiga-Ascofaré, Kennedy Gyau Boahen, Charity Wiafe Akenten, Yaw Adu-Sarkodie, Ellis Owusu-Dabo, Jürgen May
Background: The epidemiology of pediatric febrile illness is shifting in sub-Saharan Africa, but malaria remains a major cause of childhood morbidity and mortality. The present study describes causes of febrile illness in hospitalized children in Ghana and aims to determine the burden of malaria coinfections and their association with parasite densities. Methods: In a prospective study, children (aged ≥30 days and ≤15 years) with fever ≥38.0°C were recruited after admission to the pediatric ward of a primary hospital in Ghana...
February 2, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29408596/clinical-and-immunological-profiles-of-anaemia-in-children-and-adolescents-with-plasmodium-vivax-malaria-in-the-par%C3%A3-state-brazilian-amazon
#11
Ana Maria Revoredo da Silva Ventura, Andrea Aparecida Moraes Fernandes, Graziela Maria Zanini, Lilian Rose Pratt-Riccio, Carina Guilhon Sequeira, Carlos Rodrigo Souza do Monte, Arnaldo Jorge Martins Filho, Ricardo Luiz Dantas Machado, Rosana Maria Feio Libonati, José Maria de Souza, Cláudio Tadeu Daniel-Ribeiro
Children and adolescents are at great risk for developing iron deficiency anaemia worldwide. In the tropical areas, malaria and intestinal parasites may also play an important role in anaemia pathogenesis. This study aimed at evaluating clinical and immunological aspects of anaemia in children and adolescents with Plasmodium vivax malaria, in the Pará State, Brazil. A longitudinal study was performed in two Reference Centres for malaria diagnosis in the Brazilian Amazon in children and adolescents with malaria (n = 81), as compared to a control group (n = 40)...
February 1, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29406974/fever-in-the-returning-traveler
#12
REVIEW
Felicia A Scaggs Huang, Elizabeth Schlaudecker
Millions of children travel annually, whether they are refugees, international adoptees, visitors, or vacationers. Although most young travelers do well, many develop a febrile illness during or shortly after their trips. Approaching a fever in the returning traveler requires an appropriate index of suspicion to diagnose and treat in a timely manner. As many as 34% of patients with recent travel history are diagnosed with routine infections, but serious infections such as malaria, enteric fever, and dengue fever should be on the differential diagnosis due the high morbidity and mortality in children...
March 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29402283/high-prevalence-of-malaria-in-a-non-endemic-setting-comparison-of-diagnostic-tools-and-patient-outcome-during-a-four-year-survey-2013-2017
#13
Adriana Calderaro, Giovanna Piccolo, Sara Montecchini, Mirko Buttrini, Sabina Rossi, Maria Loretana Dell'Anna, Valeria De Remigis, Maria Cristina Arcangeletti, Carlo Chezzi, Flora De Conto
BACKGROUND: Malaria is no longer endemic in Italy since 1970 when the World Health Organization declared Italy malaria-free, but it is now the most commonly imported disease. The aim of the study was to analyse the trend of imported malaria cases in Parma, Italy, during January 2013-June 2017, reporting also the treatment and the outcome of cases, exploring the comparison of the three diagnostic tests used for malaria diagnosis: microscopy, immunochromatographic assay (ICT) (BinaxNOW®) and Real-time PCR assays detecting Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale curtisi, Plasmodium ovale wallikeri, and Plasmodium knowlesi...
February 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29401670/converging-human-and-malaria-vector-diagnostics-with-data-management-towards-an-integrated-holistic-one-health-approach
#14
REVIEW
Konstantinos Mitsakakis, Sebastian Hin, Pie Müller, Nadja Wipf, Edward Thomsen, Michael Coleman, Roland Zengerle, John Vontas, Konstantinos Mavridis
Monitoring malaria prevalence in humans, as well as vector populations, for the presence of Plasmodium, is an integral component of effective malaria control, and eventually, elimination. In the field of human diagnostics, a major challenge is the ability to define, precisely, the causative agent of fever, thereby differentiating among several candidate (also non-malaria) febrile diseases. This requires genetic-based pathogen identification and multiplexed analysis, which, in combination, are hardly provided by the current gold standard diagnostic tools...
February 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29395998/treatment-of-uncomplicated-and-severe-malaria-during-pregnancy
#15
REVIEW
Umberto D'Alessandro, Jenny Hill, Joel Tarning, Christopher Pell, Jayne Webster, Julie Gutman, Esperanca Sevene
Over the past 10 years, the available evidence on the treatment of malaria during pregnancy has increased substantially. Owing to their relative ease of use, good sensitivity and specificity, histidine rich protein 2 based rapid diagnostic tests are appropriate for symptomatic pregnant women; however, such tests are less appropriate for systematic screening because they will not detect an important proportion of infections among asymptomatic women. The effect of pregnancy on the pharmacokinetics of antimalarial drugs varies greatly between studies and class of antimalarial drugs, emphasising the need for prospective studies in pregnant and non-pregnant women...
January 30, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29389958/a-mobile-health-technology-platform-for-quality-assurance-and-quality-improvement-of-malaria-diagnosis-by-community-health-workers
#16
Jeremiah Laktabai, Alyssa Platt, Diana Menya, Elizabeth L Turner, Daniel Aswa, Stephen Kinoti, Wendy Prudhomme O'Meara
BACKGROUND: Community health workers (CHWs) play an important role in improving access to services in areas with limited health infrastructure or workforce. Supervision of CHWs by qualified health professionals is the main link between this lay workforce and the formal health system. The quality of services provided by lay health workers is dependent on adequate supportive supervision. It is however one of the weakest links in CHW programs due to logistical and resource constraints, especially in large scale programs...
2018: PloS One
https://www.readbyqxmd.com/read/29378594/decreased-endemic-malaria-in-suriname-moving-towards-elimination
#17
Edward D van Eer, Gustavo Bretas, Hélène Hiwat
BACKGROUND: Suriname has moved from being the country with the highest annual parasite index in the Americas to one on the threshold of elimination. The progress toward elimination in the stable populations of Suriname between 2000 and 2015 is reviewed. METHODS: Data was obtained from the Medical Mission and the Ministry of Health Malaria Programme case-reporting systems, and analysed with a focus on disease burden and differentiation of the disease geographically, by malaria species, age, gender, ethnicity, incidence and gametocytaemia...
January 30, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29378588/plasmodium-species-differentiation-by-non-expert-on-line-volunteers-for-remote-malaria-field-diagnosis
#18
Alejandra Ortiz-Ruiz, María Postigo, Sara Gil-Casanova, Daniel Cuadrado, José M Bautista, José Miguel Rubio, Miguel Luengo-Oroz, María Linares
BACKGROUND: Routine field diagnosis of malaria is a considerable challenge in rural and low resources endemic areas mainly due to lack of personnel, training and sample processing capacity. In addition, differential diagnosis of Plasmodium species has a high level of misdiagnosis. Real time remote microscopical diagnosis through on-line crowdsourcing platforms could be converted into an agile network to support diagnosis-based treatment and malaria control in low resources areas. This study explores whether accurate Plasmodium species identification-a critical step during the diagnosis protocol in order to choose the appropriate medication-is possible through the information provided by non-trained on-line volunteers...
January 30, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29378383/-concurrent-malaria-and-rickettsiosis-in-a-patient-returning-from-the-republic-of-south-africa
#19
Věra Pellantová, Pavel Kosina, Petr Prášil, Hana Zelená, Zuzana Čermáková, Stanislav Plíšek
Definitive diagnosis and therapy proved challenging in the case of a 60-year-old male with malaria and rickettsiosis. Returning travellers who are unwell can present practical difficulties in diagnosis and treatment and the focus here is on conditions relevant to the Republic of South Africa. Malaria, rickettsiosis and Q fever are discussed.
December 2017: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29378156/pseudo-irbc-beads-as-positive-control-for-cell-microarray-chip-based-detection-of-plasmodium-infected-rbcs
#20
Muneaki Hashimoto, Masahiko Numata, Shouki Yatsushiro, Yusuke Ido, Masato Tanaka, Kazuaki Kajimoto, Masatoshi Kataoka
The cell microarray chip is a polystyrene plate with 20,944 microchambers and is used to detect red blood cells (RBCs) infected with the causative agent of malaria, Plasmodium. Plasmodium-infected red blood cells (iRBCs) stained with a nuclear staining dye (SYTO 21) form a monolayer on the bottom of the microchambers, and about 130 RBCs were accommodated in each such microchamber of the chip. The iRBCs in the RBC monolayer (containing 2.7 million RBCs) can be identified using a fluorescence detector, and the infection rate can be calculated by counting the number of fluorescent positive RBCs...
January 29, 2018: Journal of Parasitology
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