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https://www.readbyqxmd.com/read/28438204/evidence-on-anti-malarial-and-diagnostic-markets-in-cambodia-to-guide-malaria-elimination-strategies-and-policies
#1
Sochea Phok, Dysoley Lek
BACKGROUND: Understanding Cambodia's anti-malarial and diagnostic landscape in 2015 is critical for informing and monitoring strategies and policies as Cambodia moves forward with national efforts to eliminate malaria. The aim of this paper is to present timely and key findings on the public and private sector anti-malarial and diagnostic landscape in Cambodia. This evidence can serve as a baseline benchmark for guiding implementation of national strategies as well as other regional initiatives to address malaria elimination activities...
April 25, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28438197/anti-malarial-landscape-in-myanmar-results-from-a-nationally-representative-survey-among-community-health-workers-and-the-private-sector-outlets-in-2015-2016
#2
Si Thu Thein, Hnin Su Su Khin, Aung Thi
BACKGROUND: In 2015/2016, an ACTwatch outlet survey was implemented to assess the anti-malarial and malaria testing landscape in Myanmar across four domains (Eastern, Central, Coastal, Western regions). Indicators provide an important benchmark to guide Myanmar's new National Strategic Plan to eliminate malaria by 2030. METHODS: This was a cross-sectional survey, which employed stratified cluster-random sampling across four regions in Myanmar. A census of community health workers (CHWs) and private outlets with potential to distribute malaria testing and/or treatment was conducted...
April 25, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28438137/case-report-of-plasmodium-ovale-curtisi-malaria-in-sri-lanka-relevance-for-the-maintenance-of-elimination-status
#3
Sharmini Gunawardena, Rachel F Daniels, Thishan C Yahathugoda, Mirani V Weerasooriya, Katelyn Durfee, Sarah K Volkman, Dyann F Wirth, Nadira D Karunaweera
BACKGROUND: Following its recent certification as malaria-free, imported infections now pose the greatest threat for maintaining this status in Sri Lanka. Imported infections may also introduce species that are uncommon or not previously endemic to these areas. We highlight in this case report the increasing importance of less common malaria species such as Plasmodium ovale in elimination settings and discuss its relevance for the risk of malaria resurgence in the country. CASE PRESENTATION: A 41-year-old patient from southern Sri Lanka was diagnosed with malaria after 8 days of fever...
April 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28434397/watching-the-availability-and-use-of-rapid-diagnostic-tests-rdts-and-artemisinin-based-combination-therapy-act
#4
Richard W Steketee, Thomas P Eisele
At the turn of this new century and after much debate, the malaria community reckoned with failing first line therapies and moved to a global recommendation for deployment of an artemisinin-based combination therapy (ACT) to treat infections due to Plasmodium falciparum. No one said it was going to be easy. This series in the Malaria Journal reports longitudinal snapshots of how the core pillar of malaria elimination of ensuring universal access to malaria diagnosis and treatment is faring-it is safe to say "not so well"...
April 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28431639/advances-in-molecular-diagnosis-of-malaria
#5
Zhi Zheng, Zhibin Cheng
Malaria is a mosquito-borne disease caused by five species of Plasmodium parasites. Accurate diagnosis of malaria plays an essential part in malaria control. With traditional diagnostic methodologies, malaria control programs have achieved remarkable success during the past decade, and are now heading toward malaria elimination in many areas. This new situation, however, calls for novel diagnostics with improved sensitivity, throughput, and reduced cost for active screening of malaria parasites, as all transfected individuals have to be identified in order to block transmission...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28421327/metal-dna-interactions-improve-signal-in-high-resolution-melting-of-dna-for-species-differentiation-of-plasmodium-parasite
#6
Priyamvada Jain, Babina Chakma, Naveen Singh, Sanjukta Patra, Pranab Goswami
The success of high-resolution melting (HRM) analysis for distinguishing similar DNAs with minor base mismatch differences is limited. Here, metal-mediated structural change in DNA has been exploited to amplify HRM signals leading to differentiation of target DNAs in an orthologous gene corresponding to four Plasmodium species. Conserved 26-mer ssDNAs from ldh gene of the four Plasmodium species were employed as targets. A capture probe (CP) that is fully complementary to the Plasmodium falciparum target (FT) and has two base mismatches each, with the targets of Plasmodium vivax (VT), Plasmodium malariae, (MT), and Plasmodium ovale (OT), was considered...
April 18, 2017: Molecular Biotechnology
https://www.readbyqxmd.com/read/28409627/simultaneous-atr-ftir-based-determination-of-malaria-parasitemia-glucose-and-urea-in-whole-blood-dried-onto-a-glass-slide
#7
Supti Roy, David Perez-Guaita, Dean W Andrew, Jack S Richards, Don McNaughton, Philip Heraud, Bayden R Wood
New diagnostic tools that can detect malaria parasites in conjunction with other diagnostic parameters are urgently required. In this study, Attenuated Total Reflection Fourier transform infrared (ATR-FTIR) spectroscopy in combination with Partial Least Square Discriminant Analysis (PLS-DA) and Partial Least Square Regression (PLS-R) have been applied as a point-of-care test for identifying malaria parasites, blood glucose and urea levels in whole blood samples from thick blood films on glass slides. The specificity for the PLS-DA was found to be 98 % for parasitemia levels >0...
April 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28406330/precarity-and-preparedness-non-adherence-as-institutional-work-in-diagnosing-and-treating-malaria-in-uganda
#8
René Umlauf
Access to anti-malarial drugs is increasingly governed by novel regulation technologies like Rapid Diagnostic Tests (RDTs). However, high-rates of non-adherence particularly to negative RDT results have been reported, threatening the cost-effectiveness of the two interrelated goals of improving diagnosis and reducing the over-prescription of expensive anti-malarial drugs. Below I set out to reconstruct prior treatment forms like presumptive treatment of malaria by paying particular attention to their institutional groundings...
April 13, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28404673/update-on-malaria-diagnostics-and-test-utilization
#9
Blaine A Mathison, Bobbi S Pritt
Malaria is a potentially life-threatening disease requiring rapid diagnosis and treatment. Although microscopic examination of thick and thin blood films remains the gold standard for laboratory diagnosis, rapid antigen tests and nucleic acid amplification methods may also play a useful role for detection of acute infection. This review discusses the advantages and disadvantages of the commonly-used diagnostic methods and provides important practice points for optimal malaria test utilization.
April 12, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28399686/prevalence-of-congenital-malaria-in-newborns-of-mothers-co-infected-with-hiv-and-malaria-in-benin-city
#10
Fidelis Ewenitie Eki-Udoko, Ayebo E Sadoh, Michael O Ibadin, Augustine I Omoigberale
BACKGROUND: HIV and Plasmodium falciparum malaria co-infection annually complicates about one million pregnancies in sub-Saharan Africa. Congenital malaria (CM) has deleterious effects on newborns. Little is known about the effect of co-infections on the prevalence of CM in infants born by these women. This study was carried out to determine the prevalence of CM in newborns of mothers co-infected with HIV and malaria compared to HIV-negative mothers with malaria in Benin-City. METHODS: Subjects were 162 newborns of mothers co-infected with HIV and malaria...
April 11, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28396771/plasmodium-spp-and-borrelia-burgdorferi-co-infection-associated-with-antiphospholipid-syndrome-in-a-returned-traveler-a-case-report
#11
Nélia Neves, André Silva-Pinto, Helena Rocha, Susana Silva, Edite Pereira, Antonio Sarmento, Lurdes Santos
The differential diagnosis of fever in a returned traveler is wide and challenging. We present a case of a patient working in Africa, who returned with fever, constitutional symptoms, headache, and blurred vision. An initial diagnosis of malaria was made, and additional workup revealed Borrelia burgdorferi co-infection and antiphospholipid syndrome.
April 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28394640/data-performativity-performing-health-work-malaria-and-labor-in-senegal
#12
Marlee Tichenor
In this article, I investigate the ramifications of health data production in the health fight against malaria in and around Dakar, Senegal. Malaria health development funding at the community level is contingent on performativity; the Global Fund's "performance-based funding," for example, requires that local actors produce certain forms of evidence and that intermediaries synthesize this evidence into citable data. Analyzing the practices of diagnosis and approximation in health clinics and in global malaria documents, I argue that data production in Senegal is conditioned by and reifies preconceived notions of malaria as a problem addressable by the enumeration of technological fixes...
April 10, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28391232/antibiotic-prescriptions-for-inpatients-having-non-bacterial-diagnosis-at-medicine-departments-of-two-private-sector-hospitals-in-madhya-pradesh-india-a-cross-sectional-study
#13
Kristoffer Landstedt, Ashish Sharma, Fredrik Johansson, Cecilia Stålsby Lundborg, Megha Sharma
OBJECTIVES: To present and compare antibiotic prescribing for inpatients among the most common non-bacterial diagnoses groups at medicine departments of a teaching (TH) and a non-teaching hospital (NTH) in central India. SETTING: An observational cross-sectional study was conducted at two tertiary care settings in Ujjain district, Madhya Pradesh, India. DATA AND PARTICIPANTS: The data were collected manually, using a customised form. Complete records of all inpatients, who were >15 years of age and had stayed for at least one night in either of the hospitals during 2008-2011, were analysed...
April 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28390423/caregivers-perception-of-malaria-and-treatment-seeking-behaviour-for-under-five-children-in-mandura-district-west-ethiopia-a-cross-sectional-study
#14
Israel Mitiku, Adane Assefa
BACKGROUND: Early diagnosis and prompt malaria treatment is essential to reduce progression of the illness to severe disease and, therefore, decrease mortality particularly among children under 5 years of age. This study assessed perception of malaria and treatment-seeking behaviour for children under five with fever in the last 2 weeks in Mandura District, West Ethiopia. METHODS: A community based cross-sectional study was conducted among 491 caregivers of children under five in Mandura District, West Ethiopia in December 2014...
April 8, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28386613/magnetically-enabled-biomarker-extraction-and-delivery-system-towards-integrated-assured-diagnostic-tools
#15
Westley S Bauer, Danielle W Kimmel, Nicholas M Adams, Lauren E Gibson, Thomas F Scherr, Kelly A Richardson, Joseph A Conrad, Hellen K Matakala, Frederick R Haselton, David W Wright
Diagnosis of asymptomatic malaria poses a great challenge to global disease elimination efforts. Healthcare infrastructure in rural settings cannot support existing state-of-the-art tools necessary to diagnose asymptomatic malaria infections. Instead, lateral flow immunoassays (LFAs) are widely used as a diagnostic tool in malaria endemic areas. While LFAs are simple and easy to use, they are unable to detect low levels of parasite infection. We have developed a field deployable Magnetically-enabled Biomarker Extraction And Delivery System (mBEADS) that significantly improves limits of detection for several commercially available LFAs...
April 7, 2017: Analyst
https://www.readbyqxmd.com/read/28372570/malaria-over-diagnosis-in-cameroon-diagnostic-accuracy-of-fluorescence-and-staining-technologies-fast-malaria-stain-and-led-microscopy-versus-giemsa-and-bright-field-microscopy-validated-by-polymerase-chain-reaction
#16
Sean M Parsel, Steven A Gustafson, Edward Friedlander, Alexander A Shnyra, Aderosoye J Adegbulu, Ying Liu, Nicole M Parrish, Syed A Jamal, Eve Lofthus, Leo Ayuk, Charles Awasom, Carolyn J Henry, Carole P McArthur
BACKGROUND: Malaria is a major world health issue and its continued burden is due, in part, to difficulties in the diagnosis of the illness. The World Health Organization recommends confirmatory testing using microscopy-based techniques or rapid diagnostic tests (RDT) for all cases of suspected malaria. In regions where Plasmodium species are indigenous, there are multiple etiologies of fever leading to misdiagnoses, especially in populations where HIV is prevalent and children. To determine the frequency of malaria infection in febrile patients over an 8-month period at the Regional Hospital in Bamenda, Cameroon, we evaluated the clinical efficacy of the Flourescence and Staining Technology (FAST) Malaria stain and ParaLens Advance(TM) microscopy system (FM) and compared it with conventional bright field microscopy and Giemsa stain (GS)...
April 4, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28369268/limitations-of-rapid-diagnostic-testing-in-patients-with-suspected-malaria-a-diagnostic-accuracy-evaluation-from-swaziland-a-low-endemicity-country-aiming-for-malaria-elimination
#17
Nikhil Ranadive, Simon Kunene, Sarah Darteh, Nyasatu Ntshalintshali, Nomcebo Nhlabathi, Nomcebo Dlamini, Stanley Chitundu, Manik Saini, Maxwell Murphy, Adam Soble, Alanna Schwartz, Bryan Greenhouse, Michelle S Hsiang
Background.: The performance of Plasmodium falciparum-specific histidine-rich protein 2-based rapid diagnostic tests (RDTs) to evaluate suspected malaria in low-endemicity settings has not been well characterized. Methods.: Using dried blood spot samples from patients with suspected malaria at 37 health facilities from 2012 to 2014 in the low-endemicity country of Swaziland, we investigated the diagnostic accuracy of histidine-rich protein 2-based RDTs using qualitative polymerase chain reaction (PCR) (nested PCR targeting the cytochrome b gene) and quantitative PCR as reference standards...
May 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28369085/defining-the-next-generation-of-plasmodium-vivax-diagnostic-tests-for-control-and-elimination-target-product-profiles
#18
Xavier C Ding, Maria Paz Ade, J Kevin Baird, Qin Cheng, Jane Cunningham, Mehul Dhorda, Chris Drakeley, Ingrid Felger, Dionicia Gamboa, Matthias Harbers, Socrates Herrera, Naomi Lucchi, Alfredo Mayor, Ivo Mueller, Jetsumon Sattabongkot, Arsène Ratsimbason, Jack Richards, Marcel Tanner, Iveth J González
The global prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical attacks without involving another mosquito bite. The diagnosis of acute patent P. vivax malaria relies primarily on light microscopy...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28357581/malaria-an-update
#19
REVIEW
Srikanta Basu, Puneet Kaur Sahi
India is endemic for malaria with unstable transmission inhibiting the development of immunity and predisposing all age groups to the disease. Children under five are the greatest sufferers with maximum mortality. P. falciparum and P. vivax cause majority of cases. Fever is the cardinal symptom, though no set of signs and symptoms reliably distinguishes malaria from other causes of fever. In all suspected cases parasitological diagnosis should be confirmed before starting the treatment. Microscopy of blood smears is the gold standard for diagnosis...
March 30, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28356231/malaria-overdiagnosis-and-subsequent-overconsumption-of-antimalarial-drugs-in-angola-consequences-and-effects-on-human-health
#20
Sylvie Manguin, Vincent Foumane, Patrick Besnard, Filomeno Fortes, Pierre Carnevale
Microscopic blood smear examinations done in health centers of Angola demonstrated a large overdiagnosis of malaria cases with an average rate of errors as high as 85%. Overall 83% of patients who received Coartem(®) had an inappropriate treatment. Overestimated malaria diagnosis was noticed even when specific symptoms were part of the clinical observation, antimalarial treatments being subsequently given. Then, malaria overdiagnosis has three main consequences, (i) the lack of data reliability is of great concern, impeding epidemiological records and evaluation of the actual influence of operations as scheduled by the National Malaria Control Programme; (ii) the large misuse of antimalarial drug can increase the selective pressure for resistant strain and can make a false consideration of drug resistant P...
March 27, 2017: Acta Tropica
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