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https://www.readbyqxmd.com/read/29225124/time-delays-in-the-diagnosis-and-treatment-of-malaria-in-non-endemic-countries-a-systematic-review
#1
REVIEW
Hamad Bastaki, Jessica Carter, Louise Marston, Jackie Cassell, Greta Rait
BACKGROUND: Delays in diagnosis and treatment for malaria are associated with an increased risk for severe disease and mortality. Identifying the extent of patient and health system delay can provide a benchmark against which interventions to reduce delays can be measured. METHODS: We performed an electronic search in PubMed, EMBASE, Web of Science and LILACS for studies reporting time to diagnosis and treatment after return from travel, onset of symptoms and seeking healthcare in non-endemic countries...
December 7, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29217380/evaluation-of-rapid-pfhrp-2-pldh-based-tests-in-diagnosing-microscopy-confirmed-falciparum-malaria-in-hodeidah-governorate-yemen
#2
Ahmed A Azazy, Ali Jamaly Alhawery, Rashad Abdul-Ghani, R A Alharbi, Shaia S R Almalki
Along with the determination of malaria infection rate among suspected patients attending hospitals in Hodeidah governorate, the present study evaluated the accuracy of Plasmodium falciparum histidine-rich protein-2 (PfHRP-2)/parasite-specific lactate dehydrogenase (pLDH)-based rapid diagnostic test (RDT) for the diagnosis of microscopy-confirmed falciparum malaria. An overall malaria infection rate of 19.3% (57/295) among suspected patients attending hospitals was microscopically confirmed. The sensitivity of thin blood films for the detection of malaria parasites was 79...
December 5, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29213208/awareness-of-malaria-and-treatment-seeking-behaviour-among-persons-with-acute-undifferentiated-fever-in-the-endemic-regions-of-myanmar
#3
Phyo Aung Naing, Thae Maung Maung, Jaya Prasad Tripathy, Tin Oo, Khin Thet Wai, Aung Thi
Background: Myanmar has a high burden of malaria with two-third of the population at risk of malaria. One of the basic elements of the Roll Back Malaria Initiative to fight against malaria is early diagnosis and treatment within 24 h of fever. Public awareness about malaria is a key factor in malaria prevention and control and in improving treatment-seeking behaviour. Methods: A large community-based survey was carried out in 27 townships of malaria endemic regions in Myanmar in 2015 which reported on the knowledge, behaviour and practices around malaria in the general population...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29211247/immunoproteomics-of-plasmodium-falciparum-infected-red-blood-cell-membrane-fractions
#4
Fernanda J Cabral, Luciana G Vianna, Marcia M Medeiros, Bianca Cechetto Carlos, Rosimeire D Martha, Nadia Maria Silva, Luiz Hildebrando P da Silva, Rodrigo G Stabeli, Gerhard Wunderlich
BACKGROUND: The surface of infected red blood cells (iRBCs) has been widely investigated because of the molecular complexity and pathogenesis mechanisms involved. Asymptomatic individuals are important in the field because they can perpetuate transmission as natural reservoirs and present a challenge for diagnosing malaria because of their low levels of circulating parasites. Recent studies of iRBC antibody recognition have shown that responses are quantitatively similar in symptomatic and asymptomatic infections, but no studies have characterised the plasmodial proteins targeted by this response...
December 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29206991/clinical-predictors-of-malaria-acute-bacterial-meningitis-and-treatment-outcomes-among-febrile-children-admitted-with-altered-mental-status-in-northwestern-tanzania
#5
Shakilu Jumanne, John Meda, Adolfine Hokororo, Kelvin Leshabari
Background: Malaria and acute bacterial meningitis (ABM) are the leading infectious causes of febrile encephalopathy in malaria endemic settings. The clinical distinction of the two conditions is complicated by overlap in clinical features. Objective: To determine the clinical predictors for malaria, ABM and treatment outcome in febrile children aged 2 months to 12 years with altered mentation at two tertiary hospitals in Northwestern Tanzania. Methods: Prospective study of 103 children to document demographic data and physical examination findings, such as level of consciousness and meningeal irritations...
November 30, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29206655/pathophysiology-clinical-presentation-and-treatment-of-coma-and-acute-kidney-injury-complicating-falciparum-malaria
#6
Katherine Plewes, Gareth D H Turner, Arjen M Dondorp
PURPOSE OF REVIEW: Cerebral impairment and acute kidney injury (AKI) are independent predictors of mortality in both adults and children with severe falciparum malaria. In this review, we present recent advances in understanding the pathophysiology, clinical features, and management of these complications of severe malaria, and discuss future areas of research. RECENT FINDINGS: Cerebral malaria and AKI are serious and well recognized complications of severe malaria...
December 4, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29203789/prevalence-of-malaria-in-two-highly-endemic-community-health-centers-in-the-bastar-district-chhattisgarh-showing-mixed-infections-with-plasmodium-species
#7
Sri Krishna, Ajay Yadav, Sneha Bhandari, Anup K Vishwakarma, Praveen K Bharti, Prem L Mandavi, Pradeep Bahgel, Sanjay Basak, Ravendra K Sharma, Neeru Singh
Malaria is a major public health problem in India and in the Chhattisgarh state. The diagnosis of malaria presents a major challenge in remote areas The prevalence of malaria in Darbha and Kilepal Community Health Centers (CHCs) of the Jagdalpur district, Chhattisgarh affected by conflict was determined using microscopy and polymerase chain reaction (PCR). In the year 2015, 29.4% and 21.5% cases were found to be positive for malaria at the Darbha and Kilepal CHCs, respectively, by microscopy, and 7.4% and 1...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29202100/immediate-assessment-of-performance-of-medical-laboratory-scientists-following-a-10-day-malaria-microscopy-training-programme-in-nigeria
#8
Bolatito Aiyenigba, Abiodun Ojo, Adolor Aisiri, Justus Uzim, Oluwole Adeusi, Halima Mwenesi
Background: Rapid and precise diagnosis of malaria is an essential element in effective case management and control of malaria. Malaria microscopy is used as the gold standard for malaria diagnosis, however results remain poor as positivity rate in Nigeria is consistently over 90%. The United States President's Malaria Initiative (PMI) through the Malaria Action Program for States (MAPS) supported selected states in Nigeria to build capacity for malaria microscopy. This study demonstrates the effectiveness of in-service training on malaria microscopy amongst medical laboratory scientists...
2017: Global Health Research and Policy
https://www.readbyqxmd.com/read/29200251/misdiagnosing-of-malaria-as-rti-decreased-after-introduction-of-rdts-in-rural-areas-of-kenya
#9
(no author information available yet)
BACKGROUND: Clinical presentation of malaria is highly variable and can be mistaken for number of other diseases, including respiratory tract diseases, which are associated with significant morbidity and mortality. However, presumptive management of fever as malaria can result in significant overdiagnosis, even in high-risk areas. Quality microscopy services for the diagnosis of malaria are not widely available in rural areas of Sub-Saharan Africa as well as in substandard conditions of low-income settings and the accuracy of microscopy is usually poor...
November 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29193853/malaria-in-india-the-need-for-new-targets-for-diagnosis-and-detection-of-plasmodium-vivax
#10
REVIEW
Swati Patankar, Shobhona Sharma, Pradipsinh K Rathod, Manoj Duraisingh
Plasmodium vivax is a protozoan parasite that is one of the causative agents of human malaria. Due to several occult features of its life cycle, P. vivax threatens to be a problem for the recent efforts towards elimination of malaria globally. With an emphasis on malaria elimination goals, we summarize the major gaps in P. vivax diagnosis and describe how proteomics technologies have begun to contribute towards the discovery of antigens that could be used for various technology platforms and applications. We suggest areas where, in the future, proteomics technologies could fill in gaps in P...
November 29, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29187150/identification-of-pathogens-for-differential-diagnosis-of-fever-with-jaundice-in-the-central-african-republic-a-retrospective-assessment-2008-2010
#11
Christelle Luce Bobossi Gadia, Alexandre Manirakiza, Gaspard Tekpa, Xavier Konamna, Ulrich Vickos, Emmanuel Nakoune
BACKGROUND: Febrile jaundice results clinically in generalized yellow coloration of the teguments and mucous membranes due to excess plasma bilirubin, accompanied by fever. Two types are found: conjugated and unconjugated bilirubin jaundice. Jaundice is a sign in several diseases due to viruses (viral hepatitis and arbovirus), parasites (malaria) and bacteria (leptospirosis). In the Central African Republic (CAR), only yellow fever is included on the list of diseases for surveillance...
November 29, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29183370/towards-malaria-elimination-in-savannakhet-lao-pdr-mathematical-modelling-driven-strategy-design
#12
Sai Thein Than Tun, Lorenz von Seidlein, Tiengkham Pongvongsa, Mayfong Mayxay, Sompob Saralamba, Shwe Sin Kyaw, Phetsavanh Chanthavilay, Olivier Celhay, Tran Dang Nguyen, Thu Nguyen-Anh Tran, Daniel M Parker, Maciej F Boni, Arjen M Dondorp, Lisa J White
BACKGROUND: The number of Plasmodium falciparum malaria cases around the world has decreased substantially over the last 15 years, but with the spread of resistance against anti-malarial drugs and insecticides, this decline may not continue. There is an urgent need to consider alternative, accelerated strategies to eliminate malaria in countries like Lao PDR, where there are a few remaining endemic areas. A deterministic compartmental modelling tool was used to develop an integrated strategy for P...
November 28, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29182619/response-of-imported-malaria-patients-to-antimalarial-medicines-in-sri-lanka-following-malaria-elimination
#13
Priyani Dharmawardena, Chaturaka Rodrigo, Kamini Mendis, W M Kumudu T de A W Gunasekera, Risintha Premaratne, Pascal Ringwald, Deepika Fernando
After eliminating local malaria transmission and being certified as a malaria-free country, Sri Lanka is facing the challenge of imported malaria. At the same time, the country has the unique opportunity to be a case study for other countries in a similar situation by approaching this issue systematically, guided by evidence. This study demonstrates the importance of developing a mechanism to detect imported malaria and adopting an evidence-based approach to study the resistance of imported malaria to anti-malarial medicines...
2017: PloS One
https://www.readbyqxmd.com/read/29181452/prevalences-of-inherited-red-blood-cell-disorders-in-pregnant-women-of-different-ethnicities-living-along-the-thailand-myanmar-border
#14
Germana Bancone, Mary Ellen Gilder, Nongnud Chowwiwat, Gornpan Gornsawun, Elsi Win, Win Win Cho, Eh Moo, Aung Myat Min, Prakaykaew Charunwatthana, Verena I Carrara, Nicholas J White, Francois Nosten, Rose McGready
Background: Inherited red blood cell disorders are prevalent in populations living in malaria endemic areas; G6PD deficiency is associated with oxidant-induced haemolysis and abnormal haemoglobin variants may cause chronic anaemia. In pregnant women, microcytic anaemia caused by haemoglobinopathies mimics iron deficiency, complicating diagnosis and treatment. Anaemia during pregnancy is associated with morbidity and mortality. The aim of this study was to characterise the prevalence of G6PD deficiency and haemoglobinopathies  among the pregnant population living along the Thailand-Myanmar border...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/29181450/cerebrospinal-fluid-markers-to-distinguish-bacterial-meningitis-from-cerebral-malaria-in-children
#15
James M Njunge, Ian N Oyaro, Nelson K Kibinge, Martin K Rono, Symon M Kariuki, Charles R Newton, James A Berkley, Evelyn N Gitau
Background. Few hospitals in high malaria endemic countries in Africa have the diagnostic capacity for clinically distinguishing acute bacterial meningitis (ABM) from cerebral malaria (CM). As a result, empirical use of antibiotics is necessary. A biochemical marker of ABM would facilitate precise clinical diagnosis and management of these infections and enable rational use of antibiotics. Methods. We used label-free protein quantification by mass spectrometry to identify cerebrospinal fluid (CSF) markers that distinguish ABM (n=37) from CM (n=22) in Kenyan children...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/29168218/the-clinical-epidemiology-of-sickle-cell-anemia-in-africa
#16
Alex W Macharia, George Mochamah, Sophie Uyoga, Carolyne M Ndila, Gideon Nyutu, Johnstone Makale, Metrine Tendwa, Emily Nyatichi, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Norbert Peshu, Benjamin Tsofa, J Anthony G Scott, Kathryn Maitland, Thomas N Williams
Sickle cell anemia (SCA) is the commonest severe monogenic disorders of humans. The disease has been highly characterized in high-income countries but not in sub-Saharan Africa where SCA is most prevalent. We conducted a retrospective cohort study of all children 0-13 years admitted from within a defined study area to Kilifi County Hospital in Kenya over a five-year period. Children were genotyped for SCA retrospectively and incidence rates calculated with reference to population data. Overall, 576 of 18,873 (3...
November 23, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29163934/determinants-of-integrated-management-of-childhood-illness-imci-non-severe-pneumonia-classification-and-care-in-malawi-health-facilities-analysis-of-a-national-facility-census
#17
Emily White Johansson, Humphreys Nsona, Liliana Carvajal-Aguirre, Agbessi Amouzou, Helena Hildenwall
Background: Research shows inadequate Integrated Management of Childhood Illness (IMCI)-pneumonia care in various low-income settings but evidence is largely from small-scale studies with limited evidence of patient-, provider- and facility-levels determinants of IMCI non-severe pneumonia classification and its management. Methods: The Malawi Service Provision Assessment 2013-2014 included 3149 outpatients aged 2-59 months with completed observations, interviews and re-examinations...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29153070/-the-importance-of-the-contribution-of-rapid-test-serological-and-molecular-methods-in-the-diagnosis-of-two-imported-malaria-cases-with-atypical-microscopy
#18
Orçun Zorbozan, Hüsnü Pullukçu, Esra Atalay Şahar, Muhammet Karakavuk, Hüseyin Can, Varol Tunali, Mert Döşkaya, Nevin Turgay, Seray Töz, Ahmet Özbilgin
Malaria is a widespread and life-threatening disease in tropical and subtropical regions. In patients with typical clinical symptoms, malaria is considered as a preliminary diagnosis if there is a travel history to malaria-endemic areas. The basis of the laboratory diagnosis of malaria is the microscopic examination of Giemsa stained smears. On the other hand, the diagnosis and differentiation of Plasmodium species with microscopic examination may have some difficulties. In the first case, adifferent appearance from the classical Plasmodium vivax erythrocytic forms in infected erythrocytes were detected in 1% of all erythrocytes in thin smear blood preparations of a 26-year-old male with complaints of fever and chills and a story of travel to Nigeria...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29143837/development-of-a-label-free-raman-imaging-technique-for-differentiation-of-malaria-parasite-infected-from-non-infected-tissue
#19
Laura Frame, James Brewer, Rebecca Lee, Karen Faulds, Duncan Graham
During malarial infection, the host uses the spleen to clear the malaria parasites, however, the parasites have evolved the ability to bind to endothelial receptors in blood vessels of tissues to avoid removal, known as sequestration, and this is largely responsible for the symptoms and severity of infection. So a technique which could non-invasively diagnose tissue burden could be utilised as an aid for localised malaria diagnosis within tissue. Raman spectroscopy is a label-free imaging technique and can provide unique and chemically specific Raman 'fingerprint' spectrum of biological samples such as tissue...
November 16, 2017: Analyst
https://www.readbyqxmd.com/read/29141032/a-qualitative-exploration-of-malaria-operational-research-situation-in-nigeria
#20
IkeOluwapo O Ajayi, Maduka D Ughasoro, Akintayo Ogunwale, Oluwaseun Odeyinka, Obafemi Babalola, Salami Sharafadeen, Al-Mukhtar Y Adamu, Olufemi Ajumobi, Taiwo Orimogunje, Patrick Nguku
BACKGROUND: Malaria, remains one of the leading causes of high morbidity and mortality in Nigeria despite implementation of several public health interventions for its control. Operational limitations and methodological gaps have been associated with malaria control interventions and research, and these have necessitated the need for a well-tailored Malaria Operational Research (MOR) agenda. However, there is paucity of evidence-based information on relevant stakeholders' experience, awareness, perceptions and use of MOR and suggestions on setting MOR agenda...
2017: PloS One
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