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https://www.readbyqxmd.com/read/29053059/the-sensitivity-and-specificity-of-a-urine-based-rapid-diagnostic-test-for-the-diagnosis-of-plasmodium-falciparum-in-a-malaria-endemic-area-in-odisha-india
#1
Ajit Gopal Samal, Prativa Kumari Behera, Akshay Kumar Mohanty, Sanghamitra Satpathi, Abhishek Kumar, Rabi Ratna Panda, Aruna Mukti Minz, Sanjib Mohanty, Abhijit Samal, Rob W Van Der Pluijm
BACKGROUND: Rapid and accurate diagnosis is crucial in the treatment of malaria. Rapid Diagnostic Tests (RDTs) using blood have been recommended by the WHO as an acceptable method for the diagnosis of malaria. RDTs provide results quickly, is simple to use and easy to interpret. However, its use requires collection of blood by skin puncture. Hence the aim of the pilot study is to explore the sensitivity and specificity of RDTs using urine (collected non-invasively) for diagnosis of Plasmodium falciparum malaria and to assess the relation between parasite density in blood with HRP-2 Ag detection in urine...
October 20, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/29046412/detection-of-plasmodium-species-by-high-resolution-melt-analysis-of-dna-from-blood-smears-acquired-in-southwestern-uganda
#2
Kennedy Kassaza, Darwin J Operario, Dan Nyehangane, K C Coffey, Mary Namugosa, Lena Turkheimer, Patrick Ojuka, Patrick Orikiriza, Juliet Mwanga-Amumpaire, Frederick Byarugaba, Joel Bazira, Jennifer L Guler, Christopher C Moore, Yap Boum
Background. Microscopic diagnosis of malaria using Giemsa-stained blood smears is the standard of care in resource-limited settings. These smears represent a potential source of DNA for polymerase chain reaction (PCR) testing to confirm Plasmodium infection or for epidemiologic studies of archived samples. Therefore, we assessed the use of DNA extracts from stained blood smears for the detection of Plasmodium species using real-time PCR.Methods. We extracted DNA from archived blood smears and corresponding red blood cell pellets collected from asymptomatic children in Southwestern Uganda in 2010...
October 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29045645/predictors-of-antimalarial-self-medication-in-illegal-gold-miners-in-french-guiana-a-pathway-towards-artemisinin-resistance
#3
M Douine, Y Lazrek, D Blanchet, S Pelleau, R Chanlin, F Corlin, L Hureau, B Volney, H Hiwat, S Vreden, F Djossou, M Demar, M Nacher, L Musset
Background: Malaria is endemic in French Guiana (FG), South America. Despite the decrease in cases in the local population, illegal gold miners are very affected by malaria (22.3% of them carried Plasmodium spp.). Self-medication seems to be very common, but its modalities and associated factors have not been studied. The aim of this study was to evaluate parasite susceptibility to drugs and to document behaviours that could contribute to resistance selection in illegal gold miners. Methods: This multicentric cross-sectional study was conducted in resting sites along the FG-Surinamese border...
October 17, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29041927/diagnostic-performance-of-the-loop-mediated-isothermal-amplification-lamp-based-illumigene-%C3%A2-malaria-assay-in-a-non-endemic-region
#4
Anne-Sophie De Koninck, Lieselotte Cnops, Mattias Hofmans, Jan Jacobs, Dorien Van den Bossche, Jan Philippé
BACKGROUND: Light microscopy and antigen-based rapid diagnostic tests are the primary diagnostic tools for detecting malaria, although being labour-intensive and frequently challenged by lack of personnel's experience and low levels of parasite density. The latter being especially important in non-endemic settings. Novel molecular techniques aim to overcome this drawback. The objective of this study was to assess the diagnostic performance of the illumigene malaria assay(®) (Meridian Bioscience) compared to microscopy, RDT and real-time PCR...
October 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29037242/malaria-risk-factors-and-care-seeking-behaviour-within-the-private-sector-among-high-risk-populations-in-vietnam-a-qualitative-study
#5
Ingrid Chen, Huong Ngo Thi Thanh, Andrew Lover, Phung Thi Thao, Tang Viet Luu, Hoang Nghia Thang, Ngo Duc Thang, Josselyn Neukom, Adam Bennett
BACKGROUND: Vietnam has successfully reduced malaria incidence by more than 90% over the past 10 years, and is now preparing for malaria elimination. However, the remaining malaria burden resides in individuals that are hardest to reach, in highly remote areas, where many malaria cases are treated through the informal private sector and are not reported to public health systems. This qualitative study aimed to contextualize and characterize the role of private providers, care-seeking behaviour of individuals at high risk of malaria, as well as risk factors that should be addressed through malaria elimination programmes in Vietnam...
October 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29037202/high-prevalence-of-very-low-plasmodium-falciparum-and-plasmodium-vivax-parasitaemia-carriers-in-the-peruvian-amazon-insights-into-local-and-occupational-mobility-related-transmission
#6
Gabriel Carrasco-Escobar, Julio Miranda-Alban, Carlos Fernandez-Miñope, Kimberly C Brouwer, Katherine Torres, Maritza Calderon, Dionicia Gamboa, Alejandro Llanos-Cuentas, Joseph M Vinetz
BACKGROUND: The incidence of malaria due both to Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon has risen in the past 5 years. This study tested the hypothesis that the maintenance and emergence of malaria in hypoendemic regions such as Amazonia is determined by submicroscopic and asymptomatic Plasmodium parasitaemia carriers. The present study aimed to precisely quantify the rate of very-low parasitaemia carriers in two sites of the Peruvian Amazon in relation to transmission patterns of P...
October 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29037193/molecular-surveillance-of-pfhrp2-and-pfhrp3-deletions-in-plasmodium-falciparum-isolates-from-mozambique
#7
Himanshu Gupta, Gloria Matambisso, Beatriz Galatas, Pau Cisteró, Lidia Nhamussua, Wilson Simone, Jane Cunningham, N Regina Rabinovitch, Pedro Alonso, Franciso Saute, Pedro Aide, Alfredo Mayor
BACKGROUND: Malaria programmes use Plasmodium falciparum histidine-rich protein-2 (PfHRP2) based rapid diagnostic tests (RDTs) for malaria diagnosis. The deletion of this target antigen could potentially lead to misdiagnosis, delayed treatment and continuation of active transmission. METHODS: Plasmodium falciparum isolates (n = 1162) collected in Southern Mozambique were assessed by RDTs, microscopy and/or 18SrRNA qPCR. pfhrp2 and pfhrp3 deletions were investigated in isolates from individuals who were negative by RDT but positive by microscopy and/or qPCR (n = 69) using gene-specific PCRs, with kelch13 PCR as the parasite DNA control...
October 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29032164/a-portable-microfluidic-aptamer-tethered-enzyme-capture-aptec-biosensor-for-malaria-diagnosis
#8
Lewis A Fraser, Andrew B Kinghorn, Roderick M Dirkzwager, Shaolin Liang, Yee-Wai Cheung, Bryce Lim, Simon Chi-Chin Shiu, Marco S L Tang, Dean Andrew, Joseph Manitta, Jack S Richards, Julian A Tanner
There is a critical need for better biosensors for the detection and diagnosis of malaria. We previously developed a DNA aptamer that recognises the Plasmodium falciparum lactate dehydrogenase (PfLDH) enzyme with high sensitivity and specificity. The aptamer was integrated into an Aptamer-Tethered Enzyme Capture (APTEC) assay as a laboratory-based diagnostic approach. However, a portable equipment-free point-of-care aptamer-mediated biosensor could have a significant impact on malaria diagnosis in endemic regions...
October 4, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29031082/quantum-associative-memory-with-linear-and-non-linear-algorithms-for-the-diagnosis-of-some-tropical-diseases
#9
J-P Tchapet Njafa, S G Nana Engo
This paper presents the QAMDiagnos, a model of Quantum Associative Memory (QAM) that can be a helpful tool for medical staff without experience or laboratory facilities, for the diagnosis of four tropical diseases (malaria, typhoid fever, yellow fever and dengue) which have several similar signs and symptoms. The memory can distinguish a single infection from a polyinfection. Our model is a combination of the improved versions of the original linear quantum retrieving algorithm proposed by Ventura and the non-linear quantum search algorithm of Abrams and Lloyd...
September 21, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29029179/sustained-malaria-control-over-an-eight-year-period-in-papua-new-guinea-the-challenge-of-low-density-asymptomatic-infections
#10
Cristian Koepfli, Maria Ome-Kaius, Shadrach Jally, Elisheba Malau, Samuel Maripal, Jason Ginny, Lincoln Timinao, Johanna Helena Kattenberg, Thomas Obadia, Michael White, Patricia Rarau, Nicolas Senn, Alyssa E Barry, James W Kazura, Ivo Mueller, Leanne J Robinson
Background: The scale-up of effective malaria control in the last decade has resulted in a substantial decline in the incidence of clinical malaria in many countries. The effects on the proportions of asymptomatic and submicroscopic infections, and on transmission potential are yet poorly understood. Methods: In Papua New Guinea, vector control has been intensified since 2008, and improved diagnosis and treatment introduced in 2012. Cross-sectional surveys were conducted in Madang Province in 2006 (n=1280), 2010 (n=2117) and 2014 (n=2516)...
September 23, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29020373/artemether-lumefantrine-versus-chloroquine-for-the-treatment-of-uncomplicated-plasmodium-knowlesi-malaria-can-know-an-open-label-randomized-controlled-trial
#11
Matthew J Grigg, Timothy William, Bridget E Barber, Giri S Rajahram, Jayaram Menon, Emma Schimann, Christopher S Wilkes, Kaajal Patel, Arjun Chandna, Ric N Price, Tsin W Yeo, Nicholas M Anstey
Background: Plasmodium knowlesi is reported increasingly across Southeast Asia, and is the commonest cause of malaria in Malaysia. No randomized trials have assessed comparative efficacy of artemether-lumefantrine (AL) for knowlesi malaria. Methods: A randomized-controlled trial was conducted in 3 district hospitals in Sabah, Malaysia to compare the efficacy of AL against chloroquine (CQ) for uncomplicated knowlesi malaria. Participants were included if >10kg, parasitemia <20,000/μL, and had a negative Pf-HRP2 rapid-diagnostic-test...
September 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020345/plasmodium-malariae-in-israeli-travelers-a-nationwide-study
#12
Yarden Yavne, Eyal Leshem, Yael Paran, Eyal Nadir, Miriam Weinberger, Michal Stein, Neta Petersiel, Dafna Yahav, Tamar Grossman, Eli Schwartz
Background: Little is known about Plasmodium malariae, a relatively rare cause of malaria in returned travelers. Recently, polymerase chain reaction (PCR) use for malaria diagnosis has enhanced specificity of P. malariae detection. The study objective was to describe the unique aspects of P. malariae diagnosis and clinical course in travelers. Methods: Malaria is a reportable disease in Israel. All PCR-proven P. malariae monoinfections in Israeli travelers between January 2008 and January 2017 were retrieved from the Ministry of Health Reference Parasitology Laboratory...
August 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020325/adapting-reactive-case-detection-strategies-for-falciparum-malaria-in-a-low-transmission-area-in-cambodia
#13
Gabriele Rossi, Rafael Van den Bergh, Chea Nguon, Mark Debackere, Lieven Vernaeve, Nimol Khim, Saorin Kim, Didier Menard, Martin De Smet, Jean-Marie Kindermans
Reactive case detection (RACD) around falciparum malaria cases in Cambodia is performed as rapid diagnostic test-based household screening around index cases, typically with a low detection rate. We improved RACD by including individuals occupationally co-exposed with index cases and PCR-based diagnosis. The positivity rate increased 20-fold, from 0.16% to 3.9%.
September 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29017499/imported-malaria-in-spain-2009-2016-results-from-the-redivi-collaborative-network
#14
Francesca F Norman, Ana López-Polín, Fernando Salvador, Begoña Treviño, Eva Calabuig, Diego Torrús, Antonio Soriano-Arandes, Jose-Manuel Ruíz-Giardín, Begoña Monge-Maillo, Jose-Antonio Pérez-Molina, Ana Perez-Ayala, Magdalena García, Azucena Rodríguez, María Martínez-Serrano, Miren Zubero, Rogelio López-Vélez
BACKGROUND: Imported malaria is a frequent diagnosis in travellers and migrants. The objective of this study was to describe the epidemiological and clinical characteristics of patients diagnosed with imported malaria within a Spanish collaborative network registering imported diseases (+REDIVI). In addition, the possible association between malaria and type of case, gender, age or area of exposure was explored. METHODS: Cases of imported malaria were identified among all cases registered in the +REDIVI database during the period October 2009-October 2016...
October 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29016341/prevalence-of-clinical-and-subclinical-plasmodium-falciparum-and-plasmodium-vivax-malaria-in-two-remote-rural-communities-on-the-china-myanmar-border
#15
Fang Huang, Shannon Takala-Harrison, Hui Liu, Jian-Wei Xu, Heng-Lin Yang, Matthew Adams, Biraj Shrestha, Gillian Mbambo, Demian Rybock, Shui-Sen Zhou, Zhi-Gui Xia, Xiao-Nong Zhou, Christopher V Plowe, Myaing M Nyunt
Malaria infections may be symptomatic, leading to treatment, or "asymptomatic," typically detected through active surveillance, and not leading to treatment. Malaria elimination may require purging both types of infection. Using detection methods with different sensitivities, we conducted a cross-sectional study in two rural communities located along the border between China's Yunnan Province and Myanmar's Shan and Kachin States, to estimate the prevalence of asymptomatic and symptomatic malaria. In Mong Pawk, all infections detected were asymptomatic, and the prevalence of Plasmodium falciparum was 0...
September 5, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28993223/international-travelers-with-infectious-diseases-determined-by-pathology-results-centers-for-disease-control-and-prevention-united-states-1995-2015
#16
Kristina M Angelo, Kira Barbre, Wun-Ju Shieh, Phyllis E Kozarsky, Dianna M Blau, Mark J Sotir, Sherif R Zaki
BACKGROUND: The failure to consider travel-related diagnoses, the lack of diagnostic capacity for specialized laboratory testing, and the declining number of autopsies may affect the diagnosis and management of travel-related infections. Pre- and post-mortem pathology can help determine causes of illness and death in international travelers. METHODS: We conducted a retrospective review of biopsy and autopsy specimens sent to the Infectious Diseases Pathology Branch laboratory (IDPBL) at the Centers for Disease Control and Prevention (CDC) for diagnostic testing from 1995-2015...
October 6, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28990918/impact-evaluation-of-malaria-control-interventions-on-morbidity-and-all-cause-child-mortality-in-rwanda-2000-2010
#17
Erin Eckert, Lia S Florey, Jon Eric Tongren, S René Salgado, Alphonse Rukundo, Jean Pierre Habimana, Emmanuel Hakizimana, Kaendi Munguti, Noella Umulisa, Monique Mulindahabi, Corine Karema
The impressive decline in child mortality that occurred in Rwanda from 1996-2000 to 2006-2010 coincided with a period of rapid increase of malaria control interventions such as indoor residual spraying (IRS); insecticide-treated net (ITN) distribution and use, and improved malaria case management. The impact of these interventions was examined through ecological correlation analysis, and robust decomposition analysis of contextual factors on all-cause child mortality. Child mortality fell 61% during the evaluation period and prevalence of severe anemia in children 6-23 months declined 71% between 2005 and 2010...
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28988739/a-tale-of-black-eschar-in-a-returning-traveller
#18
Elizabeth Liao, David Carr
BACKGROUND: African tick-bite fever is an increasingly common cause for fever in the returning traveller. It needs to be considered in the febrile returning traveller with a characteristic rash: a black eschar. CASE REPORT: We describe a 51-year-old man returning from South Africa who presented to our emergency department with fever, headache, myalgia, and chills. On careful history and skin examination, a black eschar was found on the patient's left lateral shoulder, pointing toward a diagnosis of African tick-bite fever...
October 5, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28982155/loop-mediated-isothermal-dna-amplification-for-asymptomatic-malaria-detection-in-challenging-field-settings-technical-performance-and-pilot-implementation-in-the-peruvian-amazon
#19
Elisa Serra-Casas, Paulo Manrique, Xavier C Ding, Gabriel Carrasco-Escobar, Freddy Alava, Anthony Gave, Hugo Rodriguez, Juan Contreras-Mancilla, Angel Rosas-Aguirre, Niko Speybroeck, Iveth J González, Anna Rosanas-Urgell, Dionicia Gamboa
BACKGROUND: Loop-mediated isothermal DNA amplification (LAMP) methodology offers an opportunity for point-of-care (POC) molecular detection of asymptomatic malaria infections. However, there is still little evidence on the feasibility of implementing this technique for population screenings in isolated field settings. METHODS: Overall, we recruited 1167 individuals from terrestrial ('road') and hydric ('riverine') communities of the Peruvian Amazon for a cross-sectional survey to detect asymptomatic malaria infections...
2017: PloS One
https://www.readbyqxmd.com/read/28979618/performance-of-sd-bioline-malaria-ag-pf-pan-rapid-test-in-the-diagnosis-of-malaria-in-south-kivu-dr-congo
#20
Théophile Mitima Kashosi, Joseph Minani Mutuga, Devotte Sifa Byadunia, John Kivukuto Mutendela, Basimike Mulenda, Kanigula Mubagwa
INTRODUCTION: Use of malaria rapid diagnostic tests (RDTs) has improved the management of this disease. We evaluated the validity of the SD-Bioline Malaria-Ag-Pf/Pan™ (Batch 60952) RDT supplied by the Malaria Control Program of the DRCongo. METHODS: cChildren (n = 460) aged below 5 years seen in curative care (CC) for suspected malaria and in pre-school consultation (PSC) in two rural centers underwent clinical evaluation and capillary blood collection for microscopic reading of thick smear (TS) and thin film (BF), and for RDT...
2017: Pan African Medical Journal
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