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Lp-PLA2

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https://www.readbyqxmd.com/read/28616616/lipoprotein-associated-phospholipase-a2-activity-and-its-diagnostic-potential-in-patients-with-acute-coronary-syndrome-and-acute-ischemic-stroke
#1
Sedat Kocak, Birsen Ertekin, Abdullah Sadik Girisgin, Zerrin Defne Dundar, Mehmet Ergin, Idris Mehmetoglu, Said Bodur, Basar Cander
BACKGROUND: The study examined the Lp-PLA2 activity at the patients presented to the emergency department with acute coronary syndrome (ACS) or acute ischemic stroke (AIS), as well as its diagnostic value. METHODS: The prospective study included consecutive male and female patients aged >18 years that presented to the our emergency department with ACS or AIS between November 2009 and January 2010. Blood samples were obtained immediately following diagnosis in the ACS and AIS groups...
June 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28608449/resveratrol-suppresses-lipoprotein-associated-phospholipase-a2-expression-by-reducing-oxidative-stress-in-macrophages-and-animal-models
#2
Shengnan Sun, Mingjun Zhang, Qiangbing Yang, Ziying Shen, Jiahuan Chen, Biao Yu, He Wang, Jiali Qu, Daxin Pang, Wenzhi Ren, Hongsheng Ouyang, Xiaochun Tang
SCOPE: Resveratrol is a naturally occurring polyphenolic compound with known cardioprotective, anti-inflammatory and antioxidant properties. Lipoprotein-associated phospholipase A2 (Lp-PLA2 ) is associated with the risk of cardiovascular disease. Here, we investigated the effects of resveratrol on Lp-PLA2 expression in vitro and in vivo and explored the underlying mechanisms. METHODS AND RESULTS: Human monocytic cells (THP-1) were induced to differentiate into macrophages for an in vitro experimental model...
June 13, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28524828/relationships-of-inflammatory-factors-and-risk-factors-with-different-target-organ-damage-in-essential-hypertension-patients
#3
Chun-Lin Lai, Jin-Ping Xing, Xiao-Hong Liu, Jie Qi, Jian-Qiang Zhao, You-Rui Ji, Wu-Xiao Yang, Pu-Juan Yan, Chun-Yan Luo, Lu-Fang Ruan
BACKGROUND: Atherosclerosis (AS) is an inflammatory disease. Inflammation was considered to play a role in the whole process of AS. This study aimed to analyze the relationships of inflammatory factors and risk factors with different target organ damages (TOD) in essential hypertension (EH) patients and to explore its clinical significance. METHODS: A total of 294 EH patients were selected and divided into four groups according to their conditions of TOD. Forty-eight healthy subjects were selected as control...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28514697/lipoprotein-associated-phospholipase-a2-and-risks-of-coronary-heart-disease-and-ischemic-stroke-in-the-general-population-a-systematic-review-and-meta-analysis
#4
REVIEW
Dongze Li, Wei Wei, Xun Ran, Jing Yu, Hui Li, Lizhi Zhao, Honglian Zeng, Yu Cao, Zhi Zeng, Zhi Wan
BACKGROUND: This study investigated the associations between lipoprotein-associated phospholipase A2 (Lp-PLA2) and the risks of coronary heart disease (CHD) and ischemic stroke (IS) in the general population. METHODS: PubMed, Embase, and the Cochrane Library databases were searched for prospective cohort studies published prior to June 2016. Multivariate-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for CHD and IS risks according to Lp-PLA2 activity or mass were extracted, pooled, and weighted using random-effects modeling...
May 14, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28503188/impact-of-8-week-linoleic-acid-intake-in-soy-oil-on-lp-pla2-activity-in-healthy-adults
#5
Minkyung Kim, Minjoo Kim, Ayoung Lee, Hye Jin Yoo, Jung Soo Her, Sun Ha Jee, Jong Ho Lee
BACKGROUND: No intervention follow-up study has examined the association between plasma n-6 polyunsaturated fatty acids (PUFAs) and lipoprotein-associated phospholipase A2 (Lp-PLA2), which is a risk factor for cardiovascular disease (CVD). We aimed to determine whether the administration of linoleic acid (LA, 18:2n-6) in soy oil affected Lp-PLA2 activity in healthy adults. METHODS: Self-reported healthy participants (n = 150) were randomly assigned to three groups: a low LA group, in which 10 mL soy oil was replaced with one apple; a medium LA group, in which the typical food intake was maintained; and a high LA group, in which 1/3 cup of cooked refined rice was replaced with 9...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28502488/lipoprotein-associated-phospholipase-a2-and-its-relationship-with-markers-of-subclinical-cardiovascular-disease-a-systematic-review
#6
REVIEW
Adnan Younus, Choudhry Humayun, Rameez Ahmad, Oluseye Ogunmoroti, Yugandhar Kandimalla, Muhammad Aziz, Rehan Malik, Aisha Rasool Saand, Cyndi Valdes, Rohan Badlani, Muhammad Amir Younus, Shozab S Ali, Ye Chen, Khurram Nasir
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that exhibits proinflammatory properties and has been associated with subclinical cardiovascular disease. OBJECTIVE: The relationship between Lp-PLA2 and subclinical CVD remains unclear. The goal of this systematic review was to clarify this relationship. METHODS: An extensive literature search of the MEDLINE database using Ovid and PubMed was performed. From an initial search of 444 articles, 13 met the inclusion and exclusion criteria and were included in the review...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28475940/lp-pla2-activity-and-mass-for-prediction-of-incident-abdominal-aortic-aneurysms-a-prospective-longitudinal-cohort-study
#7
Stefan Acosta, Soumia Taimour, Anders Gottsäter, Margaretha Persson, Gunnar Engström, Olle Melander, Moncef Zarrouk, Peter M Nilsson, J Gustav Smith
BACKGROUND AND AIMS: The pathogenesis of abdominal aortic aneurysm (AAA) shares several common pathways with atherosclerosis. Prospective clinical plasma biomarker studies in AAA have been hampered by the need for very large cohorts and long follow-up time. METHODS: We analyzed a prospective longitudinal cohort of middle-aged individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5551; 1991-94). The plasma biomarkers lipoprotein-associated phospholipase A2 (Lp-PLA2 activity and mass), proneurotensin and C-reactive protein, and conventional risk factors at baseline were measured in patients with incident AAA during follow-up, and compared to individuals without a diagnosis of AAA...
April 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28474283/hucmncs-protect-vascular-endothelium-and-prevent-isr-after-endovascular-interventional-therapy-for-vascular-diseases-in-t2dm-rabbits
#8
Haixia Ding, Tong Zhang, Yaping Du, Bei Liu, Yueqin Liu, Fujun Wang
The therapeutic effect of transplantation of human umbilical cord blood cell-derived mononuclear cells (HUCMNCs) on treating in-stent restenosis (ISR) after endovascular interventional therapy (EIT) was evaluated in preclinical rabbit model of type 2 diabetes mellitus (T2DM)-related peripheral artery disease (PAD). HUCMNCs were transplanted to T2DM rabbits subjected to femoral artery occlusion surgery and received EIT. Serum concentration of soluble vascular endothelial cadherin (VE-cad) and plasma concentration of lipoprotein-associated phospholipase A2 (Lp-PLA2) were determined with enzyme-linked immunosorbent assay before and after the transplantation...
May 4, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28447918/no-relation-between-biomarkers-at-age-47-49-and-aortic-diameter-after-14-19-years-of-follow-up-a-population-based-study
#9
Soumia Taimour, Moncef Zarrouk, Jan Holst, Olle Melander, Gunar Engström, J Gustav Smith, Anders Gottsäter
BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA. PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men) aged 47-49 in a prospective population-based cohort study, and related to aortic diameter at US examination of the aorta after 14-19 years of follow-up...
April 27, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#10
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28429599/lipoprotein-associated-phospholipase-a2-and-risk-of-carotid-atherosclerosis-and-cardiovascular-events-in-community-based-older-adults-in-china
#11
Chunxiu Wang, Xianghua Fang, Yang Hua, Yutong Liu, Zhongying Zhang, Xiang Gu, Xiaoguang Wu, Zhe Tang, Shaochen Guan, Hongjun Liu, Beibei Liu, Xiuhai Guo, Xunming Ji
We explored the associations between lipoprotein-associated phospholipase A2 (Lp-PLA2) level and carotid atherosclerosis with all phenotypes and cardiovascular disease (CVD) events in Chinese older adults. A total of 1257 adults aged ≥55 years who were free of CVD were enrolled in this cohort study. Lipoprotein-associated phospholipase A2 level was evaluated in 3 categories: Lp-PLA2 < 175, 175≤ Lp-PLA2 < 223, and Lp-PLA2 ≥ 223 ng/mL. The highest level of Lp-PLA2 was independently associated with common carotid artery intima-media thickening (≥1...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28413519/amp-activated-protein-kinase-mediates-the-effects-of-lipoprotein-associated-phospholipase-a2-on-endothelial-dysfunction-in-atherosclerosis
#12
Li Yang, Hong-Liang Cong, Shu-Feng Wang, Ting Liu
The present study aimed to investigate the effects of lipoprotein-associated phospholipase A2 (Lp-PLA2) on endothelial dysfunction in an in vitro cell model of atherosclerosis, and to determine whether AMP-activated protein kinase (AMPK) mediates the effects of Lp-PLA2 on endothelial dysfunction. A total of 392 patients with coronary artery disease (CAD), including various sub-conditions, were recruited, and the plasma concentrations of Lp-PLA2 were evaluated. In addition, an in vitro model of atherosclerosis was established by exposing human umbilical vein endothelial cells (HUVECs) to oxidized low-density lipoprotein (oxLDL)...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28335787/risk-factors-of-atherosclerotic-tissue-types-in-single-vessel-and-intermediate-coronary-lesions-a-cross-sectional-study
#13
Xianjin Wang, Qun Chen, Yu Xu, Yanqing Wang, Yang Yang, Ming Gu, Haihua Xu, Yanfang Zhao
BACKGROUND: Few data exist that correlate lesion-related risk factors such as conventional cardiovascular risks or lipoprotein-associated phospholipase A2 (Lp-PLA2) with tissue types within atherosclerotic plaques in patients with single-vessel and intermediate coronary lesions. METHODS: One hundred and ninety-two patients with single-vessel and intermediate coronary lesions were enrolled in a cross-sectional study and divided into two groups: stable angina pectoris (SAP) and acute coronary syndrome (ACS) groups...
March 23, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28334001/effects-of-overweight-and-the-pla2g7-v279f-polymorphism-on-the-association-of-age-with-systolic-blood-pressure
#14
Minjoo Kim, Minkyung Kim, Hye Jin Yoo, Hye Young Jang, Sang-Hyun Lee, Jong Ho Lee
This prospective study aimed to determine the effects of the persistence of overweight for three years and the PLA2G7 V279F polymorphism, as well as the interaction between these factors, on the association of age with blood pressure (BP). Healthy middle-aged subjects with normotensive BP were divided into the normal-weight and overweight groups. The PLA2G7 V279F genotype, BP, lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, and oxidized low-density lipoprotein (ox-LDL) were determined. Lp-PLA2 activity was lower in the F allele subjects (n = 111) than in those with the VV genotype (n = 389)...
2017: PloS One
https://www.readbyqxmd.com/read/28332853/correlations-between-lp-pla2-gene-polymorphisms-and-susceptibility-and-severity-of-acute-pancreatitis-in-a-chinese-population
#15
Min Ma, Chun-Xia Zhai, Cai-Xia Sun
OBJECTIVE: This case-control study explored correlations between LP-PLA2 gene polymorphisms (A379V, V279F, and R92H) and susceptibility and severity of acute pancreatitis (AP) in a Chinese population. MATERIALS AND METHODS: From October 2013 to October 2015, 94 AP patients were chosen as the case group. According to the Acute Physiology and Chronic Health Evaluation (APACHE) II score standard, AP patients were divided into a mild AP (MAP) group (n = 46) and severe AP (SAP) group (n = 48)...
April 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28289073/sympathetic-nervous-activity-in-patients-with-acute-coronary-syndrome-a-comparative-study-of-inflammatory-biomarkers
#16
COMPARATIVE STUDY
Humberto G Moreira, Rony L Lage, Daniel G Martinez, Larissa Ferreira-Santos, Maria U P B Rondon, Carlos E Negrão, José C Nicolau
Previous studies have shown that both sympathetic hyperactivity and enhanced inflammatory responses are associated with poor outcomes in patients with acute coronary syndrome (ACS). Whether there is a correlation between these two characteristics remains unclear. Thirty-four patients with uncomplicated ACS were evaluated; their mean age was 51.7±7.0 years, 79.4% were male, and 94.1% had myocardial infarction (MI). On the fourth day of hospitalization, they underwent muscle sympathetic nerve activity (MSNA) analysis (microneurography), as well as ultrasensitive C-reactive protein (usCRP), interleukin-6 (IL-6), and lipoprotein-associated phospholipase A2 (Lp-PLA2) activity measurements...
May 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28272264/the-elevated-lipoprotein-associated-phospholipase-a2-activity-is-associated-with-the-occurrence-and-recurrence-of-acute-cerebral-infarction
#17
Lingli Wei, Zunyu Ke, Yu Zhao, Zhiyou Cai
There is a strong association between lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and atherosclerosis-related diseases. The aim of this study was to investigate the role of Lp-PLA2 in the ischemic stroke and further offer clinical evidence that measuring Lp-PLA2 helps predict the risk of stroke occurrence and recurrence. A total of 328 hospitalized patients were recruited, including 179 cases of acute cerebral infarction (ACI) and 149 non-ACI controls. The serum level of Lp-PLA2 in ACI was significantly higher than non-ACI...
April 12, 2017: Neuroreport
https://www.readbyqxmd.com/read/28255125/-meta-analysis-for-the-relationship-between-lipoprotein-associated-phospholipase-a2-and-ischemic-stroke
#18
Wencui Xia, Zhongyang Hu, Zhi Song
To analyze the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) and ischemic stroke.
 Methods: Corresponding data, with case-control studies or cohorts regarding Lp-PLA2 and ischemic stroke, were retrieved from PubMed, Web of Science, Embase, the Cochrane Library, Chinese Biomedical Literature (CMB), VIP, China National Knowledge Infrastructure (CNKI), and Wanfang Database. Meta-analysis was performed by using Stata12.0.
 Results: Eight studies including 46 034 participants met the inclusion criteria...
February 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28252528/effects-of-pitavastatin-and-pravastatin-on-markers-of-immune-activation-and-arterial-inflammation-in-hiv
#19
Mabel Toribio, Kathleen V Fitch, Laura Sanchez, Tricia H Burdo, Kenneth C Williams, Craig A Sponseller, Mary McCurdy Pate, Judith A Aberg, Markella V Zanni, Steven K Grinspoon
OBJECTIVE: Persistent immune activation is thought to contribute to increased cardiovascular disease risk in HIV and statins may help modulate systemic immune activation. We aimed to compare the effects of two key statins on markers of systemic immune activation and arterial inflammation in the HIV population. DESIGN: Double-blind, active-controlled, parallel-group comparative trial performed in 45 sites. METHODS: Two hundred and fifty-two antiretroviral therapy-treated HIV-infected participants with dyslipidemia were randomized (1 : 1) to pitavastatin 4 mg daily vs...
March 27, 2017: AIDS
https://www.readbyqxmd.com/read/28222638/association-between-lp-pla2-and-coronary-heart-disease-in-chinese-patients
#20
Li Yang, Yin Liu, Shufeng Wang, Ting Liu, Hongliang Cong
Objective To evaluate the association between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2; known to release inflammatory mediators that promote atherosclerosis) and coronary heart disease (CHD) in Chinese patients. Methods This observational, cross-sectional study included a patient cohort who were assessed by coronary angiography and divided into patients with coronary heart disease and patients with normal coronary angiography (controls). Data for several biochemical indicators were collected...
February 2017: Journal of International Medical Research
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