keyword
MENU ▼
Read by QxMD icon Read
search

blood ebc

keyword
https://www.readbyqxmd.com/read/27880043/mmp-8-mmp-9-and-neutrophil-elastase-in-peripheral-blood-and-exhaled-breath-condensate-in-copd
#1
JieHao Joshua Sng, Silvie Prazakova, Paul S Thomas, Cristan Herbert
Chronic obstructive pulmonary disease (COPD) is characterised by progressive and irreversible airflow limitation associated with chronic inflammation involving cytokines and metalloproteinases (MMPs). MMP-8, MMP-9 and neutrophil elastase (NE) are known to be implicated in COPD but the factors influencing activation and suppression remain unclear. This study aimed to compare MMP-8, MMP-9 and NE in the peripheral blood of COPD patients and controls and to likewise assess exhaled breath condensate (EBC) for these MMPs...
November 23, 2016: COPD
https://www.readbyqxmd.com/read/27720040/elevated-prostaglandin-e-metabolites-and-abnormal-plasma-fatty-acids-at-baseline-in-pediatric-cystic-fibrosis-patients-a-pilot-study
#2
Michael Glenn O'Connor, Kelly Thomsen, Rebekah F Brown, Michael Laposata, Adam Seegmiller
BACKGROUND: Airway inflammation is a significant contributor to the morbidity of cystic fibrosis (CF) disease. One feature of this inflammation is the production of oxygenated metabolites, such as prostaglandins. Individuals with CF are known to have abnormal metabolism of fatty acids, typically resulting in reduced levels of linoleic acid (LA) and docosahexaenoic acid (DHA). METHODS: This is a randomized, double-blind, cross-over clinical trial of DHA supplementation with endpoints of plasma fatty acid levels and prostaglandin E metabolite (PGE-M) levels...
October 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27688240/how-strong-is-the-association-between-ipf-and-lung-cancer-an-answer-from-airway-s-dna
#3
G E Carpagnano, D Lacedonia, P Soccio, I Caccavo, G Patricelli, M P Foschino Barbaro
Idiopathic pulmonary fibrosis is a chronic progressive disease of lung interstitium of unknown etiology with poor prognosis. In patients with IPF, the incidence of lung cancer is much higher than that in the general population. The identification of noninvasive biomarkers for early diagnosis of IPF is of great relevance in consideration of the management of these patients. Among the noninvasive omic markers, an increasing interest has been directed toward the study of genetic alterations of microsatellites (MAs) in exhaled breath condensate (EBC)...
November 2016: Medical Oncology
https://www.readbyqxmd.com/read/27639372/occupational-exposure-to-anesthetics-leads-to-genomic-instability-cytotoxicity-and-proliferative-changes
#4
Kátina M Souza, Leandro G Braz, Flávia R Nogueira, Marajane B Souza, Lahis F Bincoleto, Aline G Aun, José E Corrente, Lídia R Carvalho, José Reinaldo C Braz, Mariana G Braz
Data on the genotoxic and mutagenic effects of occupational exposure to the most frequently used volatile anesthetics are limited and controversial. The current study is the first to evaluate genomic instability, cell death and proliferative index in exfoliated buccal cells (EBC) from anesthesiologists. We also evaluated DNA damage and determined the concentrations of the anesthetic gases most commonly used in operating rooms. This study was conducted on physicians who were allocated into two groups: the exposed group, which consisted of anesthesiologists who had been exposed to waste anesthetic gases (isoflurane, sevoflurane, desflurane and nitrous oxide - N2O) for at least two years; and the control group, which consisted of non-exposed physicians matched for age, sex and lifestyle with the exposed group...
September 2016: Mutation Research
https://www.readbyqxmd.com/read/27593617/effects-of-dietary-nitrate-supplementation-on-symptoms-of-acute-mountain-sickness-and-basic-physiological-responses-in-a-group-of-male-adolescents-during-ascent-to-mount-everest-base-camp
#5
Philip J Hennis, Kay Mitchell, Edward Gilbert-Kawai, Vassiliki Bountziouka, Angie Wade, Martin Feelisch, Michael P Grocott, Daniel S Martin
: The purpose of this study was to investigate the effects of dietary nitrate supplementation, in the form of beetroot juice, on acute mountain sickness (AMS) symptoms and physiological responses, in a group of young males trekking to Mount Everest Base Camp (EBC). Forty healthy male students (mean age (SD): 16 (1) yrs) trekked to EBC over 11 days. Following an overnight fast, each morning participants completed the Lake Louise AMS questionnaire and underwent a series of physiological tests: resting blood pressure as well as resting and exercising heart rate, respiratory rate, and peripheral oxygen saturation...
September 2, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/27436693/association-of-air-pollution-sources-and-aldehydes-with-biomarkers-of-blood-coagulation-pulmonary-inflammation-and-systemic-oxidative-stress
#6
Brent Altemose, Mark G Robson, Howard M Kipen, Pamela Ohman Strickland, Qingyu Meng, Jicheng Gong, Wei Huang, Guangfa Wang, David Q Rich, Tong Zhu, Junfeng Zhang
Using data collected before, during, and after the 2008 Summer Olympic Games in Beijing, this study examines associations between biomarkers of blood coagulation (vWF, sCD62P and sCD40L), pulmonary inflammation (EBC pH, EBC nitrite, and eNO), and systemic oxidative stress (urinary 8-OHdG) with sources of air pollution identified utilizing principal component analysis and with concentrations of three aldehydes of health concern. Associations between the biomarkers and the air pollution source types and aldehydes were examined using a linear mixed effects model, regressing through seven lag days and controlling for ambient temperature, relative humidity, gender, and day of week for the biomarker measurements...
July 20, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27063576/study-of-mitochondrial-dna-alteration-in-the-exhaled-breath-condensate-of-patients-affected-by-obstructive-lung-diseases
#7
G E Carpagnano, D Lacedonia, M Carone, P Soccio, G Cotugno, G A Palmiotti, G Scioscia, M P Foschino Barbaro
Mitochondrial DNA (MtDNA) has been studied as an expression of oxidative stress in asthma, COPD, lung cancer and obstructive sleep apnea, but it has been mainly investigated systemically, although the pathogenetic mechanisms begin in the airways and only later progress to systemic circulation. The aim of this study was to investigate the MtDNA alterations in the exhaled breath condensate (EBC) of patients with asthma, COPD and asthma-COPD overlap syndrome (ACOS). In order to analyze better what happens to mitochondria, both locally and systemically, we compared MtDNA/nDNA in blood and EBC of paired patients...
June 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27060205/ctcs-in-early-breast-cancer-a-path-worth-taking
#8
Roberta Maltoni, Giulia Gallerani, Pietro Fici, Andrea Rocca, Francesco Fabbri
Circulating tumor cells (CTCs) are cellular elements of undeniable significance that spread from the tumor mass into the peripheral blood and constitute one of the main vehicles for disease diffusion. Their rarity, in addition to a number of molecular and cellular features, has severely impaired research and exploitation. CTCs have been evaluated in early breast cancer (EBC), although long from being fully accepted in this field also due to a lack of technical standardization. CTCs hold promise to be a powerful non-invasive real-time measurable biomarker in all disease stages...
July 1, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27058482/measured-pulmonary-and-systemic-markers-of-inflammation-and-oxidative-stress-following-wildland-firefighter-simulations
#9
Matthew D Ferguson, Erin O Semmens, Charles Dumke, John C Quindry, Tony J Ward
OBJECTIVE: A controlled human exposure study was conducted to investigate the impact of inhalational exposures to wood smoke PM2.5 on measured concentrations of airway and systemic inflammatory biomarkers. METHODS: Mimicking wildland firefighter activities, 10 participants were exposed to three doses of wood smoke PM2.5 (filtered-air, 250 μg/m, and 500 μg/m) while exercising on a treadmill. Exhaled breath condensate (EBC) and blood plasma samples were obtained pre-, immediately post-, and 1-hour postexposure...
April 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27049101/8-isoprostane-in-exhaled-breath-condensate-after-experimental-exposure-to-wood-smoke-in-humans
#10
N Murgia, L Barregard, G Sallsten, A C Almstrand, P Montuschi, G Ciabattoni, A C Olin
Wood smoke, a well-known indoor and outdoor air pollutant, may cause adverse health effects through oxidative stress. In this study 8-isoprostane, a biomarker of oxidative stress, was measured in exhaled breath condensate (EBC) and urine before and after experimental exposure to wood smoke. The results were compared with measurements of other biomarkers of oxidative stress and inflammation. Thirteen subjects were exposed first to clean air and then, after 1 week, to wood smoke in an exposure chamber during 4-hour sessions...
January 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/26967450/the-time-to-clearance-of-peripheral-blood-blasts-predicts-complete-remission-and-survival-in-chinese-adults-with-acute-myeloid-leukemia
#11
Xiaoyang Li, Hongming Zhu, Yunxiang Zhang, Weili Zhao, Jianqing Mi, Jiong Hu, Junmin Li
The value of clearance of peripheral blood blasts (PBB) as a predictor of outcomes in acute myeloid leukemia (AML) is controversial. To investigate the prognostic significance of the time to clearance of PBB after induction in Chinese patients with AML, a retrospective analysis of 146 patients with newly diagnosed AML at Shanghai Ruijin Hospital was performed. Patients were categorized into early blast clearance (EBC; ≤5 days) and delayed blast clearance (DBC; >5 days) groups based on a receiver operating characteristic analysis...
2016: Acta Haematologica
https://www.readbyqxmd.com/read/26622752/a-phase-ii-double-blinded-study-to-evaluate-the-efficacy-of-ew02-in-reducing-chemotherapy-induced-neutropenia-in-breast-cancer
#12
Yi-Ying Wu, Hsin-Yi Liu, Tzu-Chuan Huang, Jia-Hong Chen, Ping-Ying Chang, Ching-Liang Ho, Tsu-Yi Chao
EW02, a polysaccharide-enriched crude extract from black soybean, has been shown to assist hematopoiesis in chemotherapy-treated animals. The present study aimed to clarify the safety, quality of life (QOL) and efficacy for myelopoiesis of EW02 administration in early breast cancer (EBC) patients receiving adjuvant chemotherapy. A total of 60 eligible EBC patients were enrolled in a randomized, double-blinded trial, 40 of whom were prescribed 700 mg oral EW02 three times daily for 15 days in chemotherapy cycle (C)2...
September 2015: Oncology Letters
https://www.readbyqxmd.com/read/26594121/evaluation-of-a-biosimilar-recombinant-alpha-epoetin-in-the-management-of-anemia-in-hemodialysis-patients
#13
Fatemeh Beiraghdar, Yunes Panahi, Behzad Einollahi, Eghlim Nemati, Amirhossein Sahebkar, Arash Hassanzadeh, Hamid T Khosroshahi, Sima A Azar, Javid Safa, Sadroddin R Hashemi, Jalal Etemadi, Eisa T Marzony, Hamid Noshad
BACKGROUND: The efficacy of human recombinant erythropoietins (rHuEPOs) in the treatment of anemia with different etiologies is proven. Development of biosimilar rHuEPO products with lower cost and wider availability is important for the care of anemic patients. OBJECTIVE: The aim of the present study was to determine the bioequivalence and safety of a biosimilar rHuEPO (Pastopoitin(®)) and compare it with the innovator product Eprex(®), as a standard rHuEPO. METHODS: One hundred and seven anemic patients on stable hemodialysis were recruited to this randomized double-blind comparative trial and assigned to either subcutaneous Pastopoitin (n = 50) or Eprex (n = 57)...
October 2015: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/26333431/the-effects-of-lung-recruitment-maneuvers-on-exhaled-breath-condensate-ph
#14
Brian K Walsh, Michael D Davis, John F Hunt, John N Kheir, Craig D Smallwood, John H Arnold
Exhaled breath condensate (EBC) pH serves as a surrogate marker of airway lining fluid (ALF) pH and can be used to evaluate airway acidification (AA). AA is known to be present in acute respiratory distress syndrome (ARDS) and can be evaluated via continuous EBC pH measurement during mechanical ventilation. Lung recruitment maneuvers (LRMs) are utilized in the treatment of ARDS, however, their impact on EBC pH has never been explored. Here we described the acute effects of two commonly used LRMs on EBC pH. In a prospective, non-randomized, serial exposure study, 10 intubated pediatric subjects with acute respiratory distress syndrome sequentially underwent: a period of baseline ventilation, sustained inflation (SI) maneuver of 40 cm H2O for 40 s, open lung ventilation, staircase recruitment strategy (SRS) (which involves a systematic ramping of plateau pressures in 5 cm H2O increments, starting at 30 cm H2O), and PEEP titration...
September 2015: Journal of Breath Research
https://www.readbyqxmd.com/read/26254778/t-bet-and-interleukin-27-possible-th1-immunomodulators-of-sarcoidosis
#15
Wei Sheng Joshua Loke, Araluen Freeman, Linda Garthwaite, Silvie Prazakova, Mijeong Park, Kenneth Hsu, Paul S Thomas, Cristan Herbert
BACKGROUND: Sarcoidosis has often been termed an "immune paradox" as there is peripheral anergy to common recall antigens despite pronounced TH1-dominant inflammation at disease sites, such as the lung, with up-regulation of interferon γ, IL-27 and transcription factors. Peripheral blood may reflect the anergic state, while exhaled breath condensate (EBC) analysis may offer insights into the lung disease. METHODS: A cross-sectional study was conducted to investigate the expression of TH1 cytokines and transcription factors (IFNγ, IL-27 and T-bet) in the peripheral blood and/or EBC of sarcoidosis patients and healthy controls...
October 2015: Inflammopharmacology
https://www.readbyqxmd.com/read/26184997/circulating-tumor-cells-in-early-breast-cancer-a-connection-with-vascular-invasion
#16
Roberta Maltoni, Pietro Fici, Dino Amadori, Giulia Gallerani, Claudia Cocchi, Martina Zoli, Andrea Rocca, Lorenzo Cecconetto, Secondo Folli, Emanuela Scarpi, Patrizia Serra, Francesco Fabbri
Although circulating tumor cells (CTCs) have been studied in early breast cancer (EBC), their value in this setting is still not fully understood. We isolated and studied CTCs in the peripheral blood (PB) of 48 EBC patients pre-surgery and one and 6 months post-surgery using an approach involving EpCAM-independent enrichment and a dielectrophoresis-based device. Method feasibility and the correlation between CTCs and primary tumor features were evaluated. CTCs were found in 27.1% of pre-surgery patients, 20...
October 10, 2015: Cancer Letters
https://www.readbyqxmd.com/read/26078920/ampc-beta-lactamases-among-enterobacteriaceae-isolated-at-a-tertiary-hospital-south-western-uganda
#17
Martha Nakaye, Freddie Bwanga, Herbert Itabangi, Iramiot J Stanley, Mwambi Bashir, Joel Bazira
AIM: To characterize AmpC-beta lactamases among Enterobacteriaceae isolates from clinical samples at Mbarara Regional Referral Hospital. STUDY DESIGN: Laboratory-based descriptive cross-sectional study. PLACE AND DURATION OF STUDY: Microbiology Department, Mbarara Regional Referral Hospital and MBN clinical Laboratories, between May to September 2013. METHODOLOGY: This study included 293 Enterobacteriaceae isolates recovered from clinical specimens that included blood, urine, stool and aspirates...
September 2014: British Biotechnology Journal
https://www.readbyqxmd.com/read/26028721/therapeutic-effect-of-umbelliferon-%C3%AE-d-glucopyranosyl-2-i-%C3%A2-1-ii-%C3%AE-d-glucopyranoside-on-adjuvant-induced-arthritic-rats
#18
Vikas Kumar, Firoz Anwar, Amita Verma, Mohd Mujeeb
The aim and objective of the present investigation was to evaluate the antiarthritic and antioxidant effect of umbelliferon-α-D-glucopyranosyl-(2I→1II)-α-D-glucopyranoside (UFD) in chemically induced arthritic rats. The different doses of the UFD were tested against the turpentine oil (TO), formaldehyde induced acute arthritis and complete fruend's adjuvant (CFA) induced chronic arthritis in Wistar rats. Arthritic assessment and body weight was measured at regular interval till 28 days. On day 28, all the groups animals were anaesthetized, blood were collected from the puncturing the ratro orbital and estimated the hematological parameters...
June 2015: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/25983168/patient-specific-computer-modelling-of-coronary-bifurcation-stenting-the-john-doe-programme
#19
Peter Mortier, Jolanda J Wentzel, Gianluca De Santis, Claudio Chiastra, Francesco Migliavacca, Matthieu De Beule, Yves Louvard, Gabriele Dubini
John Doe, an 81-year-old patient with a significant distal left main (LM) stenosis, was treated using a provisional stenting approach. As part of an European Bifurcation Club (EBC) project, the complete stenting procedure was repeated using computational modelling. First, a tailored three-dimensional (3D) reconstruction of the bifurcation anatomy was created by fusion of multislice computed tomography (CT) imaging and intravascular ultrasound. Second, finite element analysis was employed to deploy and post-dilate the stent virtually within the generated patient-specific anatomical bifurcation model...
2015: EuroIntervention
https://www.readbyqxmd.com/read/25972098/methodological-implications-in-ph-standardization-of-exhaled-breath-condensate
#20
F Hoffmeyer, H Berresheim, A Beine, K Sucker, T Brüning, J Bünger
The variable amount of dissolved carbon dioxide is one of the main confounding factors of exhaled breath condensate (EBC) pH measurements. There have been many attempts at identifying the optimal approach to displace CO2 as a way to gain reproducible and valid pH values in EBC samples. The aim of the present study was to assess the correlation of pH and pCO2 in untreated, neat EBC samples and, after deaeration, to reevaluate the standardization of CO2 as a means to obtain valid pH values. A further aim was to evaluate the impact of deaeration on the acid-base balance in EBC samples...
September 2015: Journal of Breath Research
keyword
keyword
77750
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"