Xiang Li, Wen Liu, Guannan Jiang, Jinrong Lian, Yi Zhong, Jialei Zhou, Haiying Li, Xingshun Xu, Yaobo Liu, Cong Cao, Jin Tao, Jian Cheng, John H Zhang, Gang Chen
Mitochondrial dysfunction contributes to the development of secondary brain injury (SBI) following intracerebral hemorrhage (ICH) and represents a promising therapeutic target. Celastrol, the primary active component of Tripterygium wilfordii, is a natural product that exhibits mitochondrial and neuronal protection in various cell types. This study aims to investigate the neuroprotective effects of celastrol against ICH-induced SBI and explore its underlying mechanisms. Celastrol improves neurobehavioral and cognitive abilities in mice with autologous blood-induced ICH, reduces neuronal death in vivo and in vitro, and promotes mitochondrial function recovery in neurons...
March 14, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)