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cyclic Adenosine monophosphate

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https://www.readbyqxmd.com/read/29053988/intermedin-reduces-neointima-formation-by-regulating-vascular-smooth-muscle-cell-phenotype-via-camp-pka-pathway
#1
Qing Zhu, Xian-Qiang Ni, Wei-Wei Lu, Jin-Sheng Zhang, Jin-Ling Ren, Di Wu, Yao Chen, Lin-Shuang Zhang, Yan-Rong Yu, Chao-Shu Tang, Yong-Fen Qi
BACKGROUND AND AIMS: Vascular smooth muscle cell (VSMC) dedifferentiation contributes to neointima formation, which results in various vascular disorders. Intermedin (IMD), a cardiovascular paracrine/autocrine polypeptide, is involved in maintaining circulatory homeostasis. However, whether IMD protects against neointima formation remains largely unknown. The purpose of this study is to investigate the role of IMD in neointima formation and the possible mechanism. METHODS: IMD1-53 (100ng/kg/h) or saline water was used on rat carotid-artery balloon-injury model...
October 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29046682/cyclic-nucleotide-monophosphates-and-their-cyclases-in-plant-signaling
#2
REVIEW
Chris Gehring, Ilona S Turek
The cyclic nucleotide monophosphates (cNMPs), and notably 3',5'-cyclic guanosine monophosphate (cGMP) and 3',5'-cyclic adenosine monophosphate (cAMP) are now accepted as key signaling molecules in many processes in plants including growth and differentiation, photosynthesis, and biotic and abiotic defense. At the single molecule level, we are now beginning to understand how cNMPs modify specific target molecules such as cyclic nucleotide-gated channels, while at the systems level, a recent study of the Arabidopsis cNMP interactome has identified novel target molecules with specific cNMP-binding domains...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29038022/a-conjugate-of-decyltriphenylphosphonium-with-plastoquinone-can-carry-cyclic-adenosine-monophosphate-but-not-cyclic-guanosine-monophosphate-across-artificial-and-natural-membranes
#3
Alexander M Firsov, Irina G Rybalkina, Elena A Kotova, Tatyana I Rokitskaya, Vadim N Tashlitsky, Galina A Korshunova, Sergei D Rybalkin, Yuri N Antonenko
The present study demonstrated for the first time the interaction between adenosine 3',5'-cyclic monophosphate (cAMP), one of the most important signaling compounds in living organisms, and the mitochondria-targeted antioxidant plastoquinonyl-decyltriphenylphosphonium (SkQ1). The data obtained on model liquid membranes and human platelets revealed the ability of SkQ1 to selectively transport cAMP, but not guanosine 3',5'-cyclic monophosphate (cGMP), across both artificial and natural membranes. In particular, SkQ1 elicited translocation of cAMP from the source to the receiving phase of a Pressman-type cell, while showing low activity with cGMP...
October 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29033942/mucosal-administration-of-cycle-di-nucleotide-adjuvanted-virosomes-efficiently-induces-protection-against-influenza-h5n1-in-mice
#4
Thomas Ebensen, Jennifer Debarry, Gabriel K Pedersen, Paulina Blazejewska, Sebastian Weissmann, Kai Schulze, Kenneth C McCullough, Rebecca J Cox, Carlos A Guzmán
The need for more effective influenza vaccines is highlighted by the emergence of novel influenza strains, which can lead to new pandemics. There is a growing population of susceptible subjects at risk for severe complications of influenza, such as the elderly who are only in part protected by current licensed seasonal vaccines. One strategy for improving seasonal and pandemic vaccines takes advantage of adjuvants to boost and modulate evoked immune responses. In this study, we examined the capacity of the recently described adjuvant cyclic di-adenosine monophosphate (c-di-AMP) to serve as an adjuvant for improved mucosal influenza vaccines, and induce effective protection against influenza H5N1...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29030458/a-noncanonical-function-of-cgamp-in-inflammasome-priming-and-activation
#5
Karen V Swanson, Robert D Junkins, Cathryn J Kurkjian, Elizabeth Holley-Guthrie, Avani A Pendse, Rachid El Morabiti, Alex Petrucelli, Glen N Barber, Chris A Benedict, Jenny P-Y Ting
Recognition of pathogen-associated molecular patterns and danger-associated molecular patterns by host cells is an important step in innate immune activation. The DNA sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) binds to DNA and produces cGAMP, which in turn binds to stimulator of interferon genes (STING) to activate IFN-I. Here we show that cGAMP has a noncanonical function in inflammasome activation in human and mouse cells. Inflammasome activation requires two signals, both of which are activated by cGAMP...
October 13, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29025575/biomarkers-in-pulmonary-vascular-disease-gauging-response-to-therapy
#6
REVIEW
Timothy J McMahon, Nathan S Bryan
Biomarkers are increasingly being investigated in the treatment of pulmonary vascular disease. In particular, the signaling pathways targeted by therapies for pulmonary arterial hypertension provide biomarkers that potentially can be used to guide therapy and to assess clinical response as an alternative to invasive procedures such as right-sided cardiac catheterization. Moreover, the growing use of combination therapy for both the initial and subsequent treatment of pulmonary arterial hypertension highlights the need for biomarkers in this treatment approach...
October 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29021704/the-effect-of-red-ginseng-and-ginseng-leaves-on-the-substance-and-energy-metabolism-in-hypothyroidism-rats
#7
Hang Xiao, Cheng Tan, Guanlin Yang, Deqiang Dou
BACKGROUND: Recent studies have revealed that the properties Traditional Chinese Medicine is mostly associated with are substance and energy metabolism. Our study aimed to compare the effect of red ginseng (RG) (warm property) and ginseng leaves (GL; cold property) on the substance and energy metabolism of rats with hypothyroidism. MATERIALS AND METHODS: Rats were administered propylthiouracil intraperitoneally for 20 d to cause hypothyroidism. The reference group was orally administered Aconiti Lateralis Radix Praeparaia [FZ (Fuzi in Chinese)], while both the RG and GL groups were orally administrated crude drugs...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29019940/effects-of-extremely-low-frequency-electromagnetic-fields-on-melanogenesis-through-p-erk-and-p-sapk-jnk-pathways-in-human-melanocytes
#8
Yu-Mi Kim, Sang-Eun Cho, Soo-Chan Kim, Hyun-Joon Jang, Young-Kwon Seo
This study evaluated frequency-dependent effects of extremely low frequency electromagnetic fields (ELF-EMFs) on melanogenesis by melanocytes in vitro. Melanocytes were exposed to 2 mT EMFs at 30-75 Hz for 3 days before melanogenesis was examined. Exposure to ELF-EMFs at 50 and 60 Hz induced melanogenic maturation without cell damage, without changing cell proliferation and mitochondrial activity. Melanin content and tyrosinase activity of cells exposed to 50 Hz were higher than in controls, and mRNA expression of tyrosinase-related protein-2 was elevated relative to controls at 50 Hz...
October 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28993962/deep-sequencing-reveals-the-significant-involvement-of-camp-related-signaling-pathways-following-sciatic-nerve-crush
#9
Jun Yu, Sijia Wang, Chen Wu, Sheng Yi
Peripheral nerve injury and regeneration is a complex biological process jointly mediated by numerous factors. Cyclic adenosine monophosphate (cAMP) modifies the cellular behaviors of neurons and Schwann cells, and thus may contribute to peripheral nerve regeneration. Despite the importance of cAMP, the temporal and spatial expressions of genes involved in cAMP-related signaling pathways during peripheral nerve regeneration remain unclear. In the current study, by using rat sciatic nerve crush model, we analyzed previously obtained RNA deep sequencing data, explored the significance of cAMP-mediated signaling pathway and protein kinase A (PKA) signaling pathway after peripheral nerve injury, and examined the expression patterns of genes involved in these cAMP-related signaling pathways...
October 9, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28993465/camp-signaling-mediates-behavioral-flexibility-and-consolidation-of-social-status-in-drosophila-aggression
#10
Nitin Singh Chouhan, Krithika Mohan, Aurnab Ghose
Social rituals, like male-male aggression in Drosophila, are often stereotyped and the component behavioral patterns modular. The likelihood of transition from one behavioral pattern to another is malleable by experience and confers flexibility to the behavioral repertoire. Experience-dependent modification of innate aggressive behavior in flies alters fighting strategies during fights and establishes dominant-subordinate relationships. Dominance hierarchies resulting from agonistic encounters are consolidated to longer lasting social status-dependent behavioral modifications resulting in a robust loser effect...
October 9, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28993145/an-inhibitory-mechanism-of-action-of-a-novel-syringic-acid-derivative-on-%C3%AE-melanocyte-stimulating-hormone-%C3%AE-msh-induced-melanogenesis
#11
Yoon Ju Jeong, Jae-Young Lee, Jino Park, Soo Nam Park
AIMS: To report the effects of a novel syringic-acid derivative, (R)-ethyl-2-acetamido-3-(4-hydroxy-3,5-dimethoxybenzoylthio)propanoate (EABTO), on melanin synthesis and to identify its mechanism of action in B16F1 melanoma cells. METHODS: The effects of EABTO on melanin synthesis in B16F1 cells and human epidermal melanocytes and the influence on cell-free tyrosinase activity were evaluated. EABTO-induced cellular signaling cascades were studied by western blotting...
October 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/28987709/impact-of-levosimendan-on-platelet-function
#12
Joanna Sikora, Krzysztof Pstrągowski, Natalia Skibińska, Przemysław Sobczak, Adam Sikora, Michał Piotr Marszałł, Tomasz Fabiszak, Grzegorz Grześk, Jacek Kubica
Levosimendan has been developed for treatment of severe heart failure. The favorable hemodynamic effect of levosimendan is related to its unique dual mechanism of action - increase of the contractile force of the myocardium caused by enhanced sensitivity of myofilaments to calcium combined with vasodilatation caused by the opening of adenosine triphosphate - dependent potassium channels. Due to the structural similarities to phosphodiesterase inhibitors it may partly exert its action via inhibition of phosphodiesterase inhibitors III...
October 2, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28977595/glucose-sensitive-cftr-suppresses-glucagon-secretion-by-potentiating-katp-channels-in-pancreatic-islet-%C3%AE-cells
#13
Wen Qing Huang, Jing Hui Guo, Xiao Hu Zhang, Mei Kuen Yu, Yiu Wa Chung, Ye Chun Ruan, Hsiao Chang Chan
The secretion of glucagon by islet α cells is normally suppressed by high blood glucose, but this suppressibility is impaired in patients with diabetes or cystic fibrosis (CF), a disease caused by mutations in the gene encoding CF transmembrane conductance regulator (CFTR), a cyclic adenosine monophosphate-activated Cl- channel. However, precisely how glucose regulates glucagon release remains controversial. Here we report that elevated glucagon secretion, together with increased glucose-induced membrane depolarization and Ca2+ response, is found in CFTR mutant (DF508) mice/islets compared with the wild-type...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28977591/novel-function-of-a-transcription-factor-wt1-in-regulating-decidualization-in-human-endometrial-stromal-cells-and-its-molecular-mechanism
#14
Isao Tamura, Yuichiro Shirafuta, Kousuke Jozaki, Takuya Kajimura, Masahiro Shinagawa, Ryo Maekawa, Toshiaki Taketani, Hiromi Asada, Shun Sato, Hiroshi Tamura, Norihiro Sugino
The Wilms tumor suppressor gene (WT1) encodes an essential transcription factor regulating mammalian urogenital development. However, the function of WT1 in human endometrium is still unclear. The current study examined the involvement of WT1 in the regulation of IGF-binding protein-1 (IGFBP-1) and prolactin (PRL), which are specific markers of decidualization, in human endometrial stromal cells (ESCs) undergoing decidualization. ESCs isolated from proliferative-phase endometrium were incubated with cyclic adenosine monophosphate (cAMP) to induce decidualization...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28973639/1-2-dichloroethane-induces-reproductive-toxicity-mediated-by-the-crem-creb-signaling-pathway-in-male-nih-swiss-mice
#15
Yating Zhang, Guoliang Li, Yizhou Zhong, Manqi Huang, Jiejiao Wu, Jiewei Zheng, Weifeng Rong, Lihai Zeng, Xiao Yin, Fengrong Lu, Zhiwei Xie, Dandan Xu, Qiming Fan, Xiaohui Jia, Ting Wang, Qiansheng Hu, Wen Chen, Qing Wang, Zhenlie Huang
1,2-Dichloroethane (1,2-DCE) is a widely used chlorinated organic toxicant, but little is known about the reproductive disorders induced by its excessive exposure. To reveal 1,2-DCE-induced male reproductive toxicity and to elucidate the underlying mechanisms, we exposed male NIH Swiss mice to 1,2-DCE by inhalation at 0, 100, 350, and 700 mg/m3 for 6 h/day, for 1 and 4 weeks. Our findings showed a significant decrease in body weight with increased testis/body weight ratio, reduced sperm concentration and induced malformation of spermatozoa, and vacuolar degeneration of germ cells in the seminiferous tubules of testes in mice exposed to 1,2-DCE...
August 30, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28967916/organoid-cystogenesis-reveals-a-critical-role-of-microenvironment-in-human-polycystic-kidney%C3%A2-disease
#16
Nelly M Cruz, Xuewen Song, Stefan M Czerniecki, Ramila E Gulieva, Angela J Churchill, Yong Kyun Kim, Kosuke Winston, Linh M Tran, Marco A Diaz, Hongxia Fu, Laura S Finn, York Pei, Jonathan Himmelfarb, Benjamin S Freedman
Polycystic kidney disease (PKD) is a life-threatening disorder, commonly caused by defects in polycystin-1 (PC1) or polycystin-2 (PC2), in which tubular epithelia form fluid-filled cysts. A major barrier to understanding PKD is the absence of human cellular models that accurately and efficiently recapitulate cystogenesis. Previously, we have generated a genetic model of PKD using human pluripotent stem cells and derived kidney organoids. Here we show that systematic substitution of physical components can dramatically increase or decrease cyst formation, unveiling a critical role for microenvironment in PKD...
October 2, 2017: Nature Materials
https://www.readbyqxmd.com/read/28963955/structural-investigation-of-vesnarinone-at-the-pore-domains-of-open-and-open-inactivated-states-of-herg1-k-channel
#17
Gülru Kayık, Nurcan Ş Tüzün, Serdar Durdagi
In this study, the dynamics of vesnarinone bounded hERG1 K(+) channels are investigated using in silico approaches such as molecular docking, molecular dynamics (MD) simulations, MM/PBSA (Molecular Mechanics/Poisson Boltzmann Surface Area) calculations and Principal Component Analysis (PCA). Vesnarinone (a cardiotonic agent) falls into a category of drugs that inhibit phosphodiesterase 3-type (PDE3) enzymes. PDE3 enzymes have specific roles in the dehydyrolysis of intracellular second messengers 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP)...
September 6, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28962697/pentoxifylline-inhibits-lipopolysaccharide-induced-inflammatory-mediators-in-human-second-trimester-placenta-explants
#18
Esther M Speer, Xinhua Lin, Amitasrigowri Murthy, Wei Hou, Shahidul Islam, Nazeeh Hanna
BACKGROUND: Intrauterine infection and inflammation during pregnancy, which leads to up-regulation of inflammatory cytokines and prostaglandin synthesis, has been implicated in the pathogenesis of preterm delivery and other pregnancy complications. Effective preventive and therapeutic strategies to reduce these outcomes are lacking to date. Pentoxifylline (PTX) is a non-specific phosphodiesterase inhibitor which raises intracellular cyclic adenosine monophosphate and decreases production of pro-inflammatory mediators while enhancing anti-inflammatory cytokines...
October 2017: Placenta
https://www.readbyqxmd.com/read/28959912/endothelium-specific-amyloid-precursor-protein-deficiency-causes-endothelial-dysfunction-in-cerebral-arteries
#19
Livius V d'Uscio, Tongrong He, Anantha V Santhanam, Zvonimir S Katusic
The exact physiological function of amyloid-β precursor protein (APP) in endothelial cells is unknown. Endothelium-specific APP-deficient (eAPP(-/-)) mice were created to gain new insights into the role of APP in the control of vascular endothelial function. Endothelium-dependent relaxations to acetylcholine were significantly impaired in basilar arteries of global APP knockout (APP(-/-)) and eAPP(-/-) mice ( P < 0.05). In contrast, endothelium-independent relaxations to nitric oxide (NO)-donor diethylamine-NONOate were unchanged...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28959341/expression-of-recombinant-phosphodiesterases-3a-and-3b-using-baculovirus-expression-system
#20
Yongmin Yan, Wenqian Jiang, Jingwen Liu, Wenrong Xu, Hui Qian
BACKGROUND: Phosphodiesterase 3A (PDE3A) and phosphodiesterase 3B (PDE3B) play a critical role in the regulation of intracellular level of adenosine 3´,5´-cyclic monophosphate (cyclic AMP, cAMP) and guanosine 3´,5´-cyclic monophosphate (cyclic GMP, cGMP). Subsequently PDE3 inhibitors have shown to relax vascular and inhibit platelet aggregation in cardiovascular disease. OBJECTIVES: In this study, our aim was to establish a method of expression for the recombinant human PDE3A and PDE3B proteins in insect cells using baculovirus expression system in order to investigate the activity of the expressed PDE3A and PDE3B proteins...
December 2016: Iranian journal of biotechnology
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