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cyclic Adenosine monophosphate

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https://www.readbyqxmd.com/read/29452068/glycyrrhizin-attenuates-histamine-mediated-muc5ac-upregulation-inflammatory-cytokine-production-and-aquaporin-5-downregulation-through-suppressing-the-nf-%C3%AE%C2%BAb-pathway-in-human-nasal-epithelial-cells
#1
Haixia Li, Dandan Guo, Liangran Zhang, Xiao Feng
Allergic rhinitis (AR) is a chronic respiratory inflammatory disease. Glycyrrhizin is a main bioactive component of the licorice root extract and exhibits anti-inflammatory activity. However, the role of glycyrrhizin in AR has not been studied. The aim of the present study was to investigate the effect of glycyrrhizin on histamine-induced human nasal epithelial cells (HNEpCs). Here, we found that glycyrrhizin (20 or 40 μM) inhibited histamine-induced the mRNA expression and secretion of mucin 5 subtype AC (MUC5AC), interleukin (IL)-6 and IL-8 in HNEpCs...
February 13, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29446653/cgas-mediated-autophagy-protects-the-liver-from-ischemia-reperfusion-injury-independent-of-sting
#2
Zhao Lei, Meihong Deng, Zhongjie Yi, Qian Sun, Richard A Shapiro, Hongbo Xu, Tunliang Li, Patricia A Loughran, John E Griepentrog, Hai Huang, Melanie J Scott, Feizhou Huang, Timothy R Billiar
Liver ischemia/reperfusion (I/R) injury occurs through induction of oxidative stress and release of damage-associated molecular patterns (DAMPs), including cytosolic DNA released from dysfunctional mitochondria or from the nucleus. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor known to trigger stimulator of interferon genes (STING) and downstream type1 interferon (IFN-I) pathways, which are pivotal innate immune system responses to pathogen. However, little is known about the role of cGAS/STING in liver I/R injury...
February 15, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29444417/a-study-on-the-regenerative-effect-of-platelets-rich-plasma-on-experimentally-induced-hepatic-damage-in-albino-rats
#3
Heba Mamdoh Shoeib, Walaa Arafa Keshk, Abdallah Mahmoud Foda, Saad El-Deen Abd Elfatah Abo El Noeman
Hepatic fibrosis is a worldwide health problem with significant morbidity and mortality. Currently, there is no effective therapy for hepatic fibrosis. So that the present study was aimed to evaluate the possible regenerative effect of Platelet-rich plasma (PRP) against thioacetamide (TAA) induced hepatic damage. Eighty albino rats were included; 40 were used for PRP preparation and 40 were randomly divided into four groups. Group I (control group); group II (PRP control); group III (TAA- intoxicated in a dose of 200 mg ∕ kg body weight/twice weekly for 7 weeks, intra-peritoneal and group IV (TAA-intoxicated+ PRP treated)...
February 14, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29442223/beneficial-role-of-low-intensity-laser-irradiation-on-neural-%C3%AE-tubulin-iii-protein-expression-in-human-bone-marrow-multipotent-mesenchymal-stromal-cells
#4
Valéria Ferreira-Silva, Fernando L Primo, Munira M A Baqui, Danielle A R Magalhães, Maristela D Orellana, Andrielle Castilho-Fernandes, Mario C Cruz, Niehls O S Câmara, Dimas T Covas, Antonio C Tedesco
The purpose of the present study was to evaluate the neural protein expression pattern of human multipotent mesenchymal stromal cells (hMSCs) treated with forskolin (free-form/FF). The study investigated forskolin's capacity to enhance intracellular levels of cyclic adenosine monophosphate (cAMP) by activating adenylate cyclase and probably by inducing neuron-like cells in vitro. In addition, because nanotechnology is a growing field of tissue engineering, we also assessed the action of a new system called the nanostructured-forskolin (NF) to examine the improvement of drug delivery...
February 13, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29434807/influence-of-sevoflurane-exposure-on-mitogen-activated-protein-kinases-and-akt-gsk-3%C3%AE-crmp-2-signaling-pathways-in-the-developing-rat-brain
#5
Yafang Liu, Chuiliang Liu, Minting Zeng, Xue Han, Kun Zhang, Yanni Fu, Jue Li, Yujuan Li
Prolonged exposure to volatile anesthetics causes neurodegeneration in developing animal brains. However, their underlying mechanisms of action remain unclear. The current study investigated the expression of proteins associated with the mitogen-activated protein kinases (MAPK) and protein kinase B (Akt)/glycogen synthase kinase-3β (GSK-3β)/collapsin response mediator protein 2 (CRMP-2) signaling pathways in the cortices of neonatal mice following exposure to sevoflurane. Seven-day-old (P7) neonatal C57BL/6 mice were randomly divided into 2 groups and either exposed to 2...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29419761/a-kinase-anchoring-protein-lbc-a-molecular-scaffold-involved-in-cardiac-protection
#6
REVIEW
Dario Diviani, Halima Osman, Erica Reggi
Heart failure is a lethal disease that can develop after myocardial infarction, hypertension, or anticancer therapy. In the damaged heart, loss of function is mainly due to cardiomyocyte death and associated cardiac remodeling and fibrosis. In this context, A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that facilitate the spatiotemporal activation of the cyclic adenosine monophosphate (AMP)-dependent protein kinase (PKA) and other transduction enzymes involved in cardiac remodeling...
February 8, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29417848/triiodothyronine-stimulates-vegf-expression-and-secretion-via-steroids-and-hif-1%C3%AE-in-murine-leydig-cells
#7
Bodhana Dhole, Surabhi Gupta, Senthil Kumar Venugopal, Anand Kumar
Leydig cells are the principal steroidogenic cells of the testis. Leydig cells also secrete a number of growth factors including vascular endothelial growth factor (VEGF) which has been shown to regulate both testicular steroidogenesis and spermatogenesis. The thyroid hormone, T3, is known to stimulate steroidogenesis in Leydig cells. T3 has also been shown to stimulate VEGF production in a variety of cell lines. However, studies regarding the effect of T3 on VEGF synthesis and secretion by the Leydig cells were lacking...
February 8, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29416917/camp-induces-cell-apoptosis-in-multiple-myeloma-and-overcomes-bortezomib-resistance
#8
Yingying Wang, Yong Tang, Haifang Hang, Mingming Wang, Yuyang Pang, Yehua Yu, Yingli Wu, Qi Zhu
The acquired resistance to bortezomib represents a major obstacle for multiple myeloma (MM) treatment. Studies revealed that the treatment with cyclic adenosine monophosphate (cAMP) may be a promising strategy for MM therapy. Therefore, the present study aimed to explore the mechanism of action of cAMP in MM cells. Our results showed that 8-CPT-cAMP and bortezomib synergistically induced growth inhibition and apoptosis in MM bortezomib-resistant cell lines and primary MM cells, in which protein kinase A (PKA) activation was involved...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29414332/effects-of-mclr-exposure-on-sex-hormone-synthesis-and-reproduction-related-genes-expression-of-testis-in-male-rana-nigromaculata
#9
Xiuying Jia, Zhengquan Liu, Xiangjun Lu, Juan Tang, Yingzhu Wu, Qiongxia Du, Jianbo He, Xinyun Zhang, Jinxiao Jiang, Wenli Liu, Yuqing Zheng, Ying Ding, Weiqin Zhu, Hangjun Zhang
Microcystin-leucine-arginine (MCLR) is the most popular and toxic variant among microcystins, which can cause severe reproductive toxicity to animals. However, the mechanisms of reproductive toxicity induced by MCLR in amphibians are still not entirely clear. In the current study, toxicity mechanisms of MCLR on the reproductive system of male Rana nigromaculata followed by low concentration (0, 0.1, 1, and 10 μg/L) and short-term (0, 7, and 14 days) MCLR exposure were shown. It was observed that MCLR could be bioaccumulated in the testes of male frogs, and the theoretical bioaccumulation factor values were 0...
February 1, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29413592/affinity-induced-immobilization-of-adenylate-cyclase-from-the-crude-cell-lysate-for-atp-conversion
#10
Qianqian Zhu, Wei Zhuang, Huanqing Niu, Lei Ge, Byron Villacorta Hernandez, Jinglan Wu, Kai Wang, Dong Liu, Yong Chen, Chenjie Zhu, Hanjie Ying
The development of an orientation immobilization technique via affinity between polyhistidine tags and metal ions aims at maintaining biocatalytic activity of the enzymes. In this work, to tackle the issue of the immobilization of adenylate cyclase (AC), a simple and effective approach of synthesizing iminodiacetic acid (IDA)-Ni2+ particles was applied for simultaneously purifying and immobilizing his-tagged AC. We chose agarose particles as carriers, and then decorated them with IDA, leading to the formation of a coordination combination of Ni2+...
January 26, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29412765/nomad-biosensors-a-new-multiplexed-technology-for-the-screening-of-gpcr-ligands
#11
Rosa M Mella, Danel Kortazar, Meritxell Roura-Ferrer, Clarisa Salado, María Valcárcel, Amaia Castilla, Patricia Villacé
Nomad Technology (Innoprot [Innovative Technologies in Biological Systems], Derio, Spain), a novel tool for multiplexing high-throughput cell-based G protein-coupled receptor (GPCR) assays, is described in this work. This new technology comprises a family of fluorescent biosensors called Nomad Biosensors that allow for the measurement of responses mediated by G proteins through their interactions with second-messenger transduction proteins. GPCRs are one of the largest protein families of receptors in eukaryotes, and their signaling mediates important physiological processes within cells...
February 1, 2018: SLAS Technology
https://www.readbyqxmd.com/read/29408093/analysis-of-the-pharmacological-properties-of-jwh-122-isomers-and-thj-2201-rcs-4-and-ab-chminaca-in-hek293t-cells-and-hippocampal-neurons
#12
Willard J Costain, Ingrid Rasquinha, Tanya Comas, Melissa Hewitt, Amy Aylsworth, Yanouchka Rouleau, Vincent Marleau, Evelyn C Soo, Joseph S Tauskela
Synthetic cannabinoids are marketed as legal alternatives to Δ9-THC, and are a growing worldwide concern as these drugs are associated with severe adverse effects. Unfortunately, insufficient information regarding the physiological and pharmacological effects of emerging synthetic cannabinoids (ESCs) makes their regulation by government authorities difficult. One strategy used to evade regulation is to distribute isomers of regulated synthetic cannabinoids. This study characterized the pharmacological properties of a panel of ESCs in comparison to Δ9-THC, as well as six JWH-122 isomers relative to its parent compound (JWH-122-4)...
February 2, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29404958/peripheral-and-central-effects-of-memantine-in-a-mixed-preclinical-mice-model-of-obesity-and-familial-alzheimer-s-disease
#13
Miren Ettcheto, Elena Sánchez-López, Yaiza Gómez-Mínguez, Henrry Cabrera, Oriol Busquets, Carlos Beas-Zarate, Maria Luisa García, Eva Carro, Gemma Casadesus, Carme Auladell, Manuel Vázquez Carrera, Jaume Folch, Antoni Camins
There is growing evidence that obesity associated with type 2 diabetes mellitus (T2DM) and aging are risk factors for the development of Alzheimer's disease (AD). However, the molecular mechanisms through which obesity interacts with β-amyloid (Aβ) to promote cognitive decline remains poorly understood. Memantine (MEM), a N-methyl-D-aspartate receptor antagonist, is currently used for the treatment of AD. Nonetheless, few studies have reported its effects on genetic preclinical models of this neurodegenerative disease exacerbated with high-fat diet (HFD)-induced obesity...
February 5, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29402503/environmental-training-is-beneficial-to-clinical-symptoms-and-cortical-presynaptic-defects-in-mice-suffering-from-experimental-autoimmune-encephalomyelitis
#14
T Bonfiglio, G Olivero, M Vergassola, L Di Cesare Mannelli, A Pacini, F Iannuzzi, M Summa, R Bertorelli, M Feligioni, C Ghelardini, A Pittaluga
The effect of "prophylactic" environmental stimulation on clinical symptoms and presynaptic defects in mice suffering from the experimental autoimmune encephalomyelitis (EAE) at the acute stage of disease (21 ± 1 days post immunization, d.p.i.) was investigated. In EAE mice raised in an enriched environment (EE), the clinical score was reduced when compared to EAE mice raised in standard environment (SE).Concomitantly, gain of weight and increased spontaneous motor activity and curiosity were observed, suggesting increased well-being in mice...
February 2, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29402369/-effect-of-silencing-aquaporin-4-on-learning-and-memory-dysfunction-in-rats-with-traumatic-brain-injury
#15
Ao Xiong, Ge Jin, Renping Xiong, Hong Lu
OBJECTIVE: To observe the protein expression related to cognitive and learning memory function, and to investigate the effect of aquaporin 4 (AQP4) silence on learning and memory function in traumatic brain injury (TBI) rats. METHODS: Ninety-six healthy adult male Wistar rats were divided into groups according to the random number table. (1) Forty-eight rats were divided into sham operation (sham) group, TBI group (by using modified Feeney method), AQP4 RNA interference (RNAi) negative group [TBI+meaningless small interfering RNA (siRNA)-AQP4 liposome solution 10 μL], and AQP4 RNAi group (TBI+siRNA-AQP4 liposome solution 10 μL)...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29402362/-effects-of-mild-hypothermia-on-%C3%AE-adrenergic-signaling-pathway-in-a-cardiac-arrest-swine-model
#16
Fangfang Zhu, Xianfei Ji, Xia Zhong, Haoran Hu, Lining Liang, Jibin Chen, Deya Shang
OBJECTIVE: To observe the effect of mild hypothermia on myocardial β-adrenergic receptor (β-AR) signal pathway after cardiopulmonary resuscitation (CPR) in pigs with cardiac arrest (CA) and explore the mechanism of myocardial protection. METHODS: Healthy male Landraces were collected for reproducing the CA-CPR model (after 8-minute untreated ventricular fibrillation, CPR was implemented). The animals were divided into two groups according to random number table (n = 8)...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29399083/investigation-of-the-molecular-mechanisms-underlying-postoperative-recurrence-in-prostate-cancer-by-gene-expression-profiling
#17
Cheng Yajun, Tang Yuan, Wang Zhong, Xu Bin
The present study aimed to identify potential genes associated with prostate cancer (PCa) recurrence following radical prostatectomy (RP) in order to improve the prediction of the prognosis of patients with PCa. The GSE25136 microarray dataset, including 39 recurrent and 40 non-recurrent PCa samples, was downloaded from the Gene Expression Omnibus database. Differentially-expressed genes (DEGs) were identified using limma packages, and the pheatmap package was used to present the DEGs screened using a hierarchical cluster analysis...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29392776/a-homozygous-loss-of-function-mutation-in-pde2a-associated-to-early-onset-hereditary-chorea
#18
Vincenzo Salpietro, Belen Perez-Dueñas, Kosuke Nakashima, Victoria San Antonio-Arce, Andreea Manole, Stephanie Efthymiou, Jana Vandrovcova, Conceicao Bettencourt, Niccolò E Mencacci, Christine Klein, Michy P Kelly, Ceri H Davies, Haruhide Kimura, Alfons Macaya, Henry Houlden
BACKGROUND: We investigated a family that presented with an infantile-onset chorea-predominant movement disorder, negative for NKX2-1, ADCY5, and PDE10A mutations. METHODS: Phenotypic characterization and trio whole-exome sequencing was carried out in the family. RESULTS: We identified a homozygous mutation affecting the GAF-B domain of the 3',5'-cyclic nucleotide phosphodiesterase PDE2A gene (c.1439A>G; p.Asp480Gly) as the candidate novel genetic cause of chorea in the proband...
February 2, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29386470/formation-of-8-s-l-cysteinyladenosine-from-8-bromoadenosine-and-cysteine
#19
Toshinori Suzuki, Akihiro Ogishi, Toru Shinohara, Shinya Suito
When 8-bromoadenosine was incubated with cysteine at pH 7.2 and 37°C, an exclusive product was generated. This product was identified as a cysteine substitution derivative of adenosine at the 8 position, 8-S-L-cysteinyladenosine. The reaction accelerated as pH increased from mildly acidic to basic conditions. The isolated cysteine adduct of adenosine decreased with a half-life of 15 h at pH 7.2 and 37°C. Similar results were obtained for the incubation of 8-bromo-2'-deoxyadenosine and 8-bromoadenosine 3',5'-cyclic monophosphate with cysteine...
2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29385487/microrna-221-expression-in-theca-and-granulosa-cells-hormonal-regulation-and-function
#20
C L Robinson, L Zhang, L F Schütz, M L Totty, L J Spicer
Small non-coding RNA molecules (miRNA) regulate protein levels in a post-transcriptional manner by partial base pairing to the 3'-UTR of target genes thus mediating degradation or translational repression. Previous studies indicate that numerous miRNA regulate the biosynthesis of intraovarian hormones, and emerging evidence indicates that one of these, miRNA-221 (MIR221), may be a modulator of ovarian function. However, the hormonal control of ovarian MIR221 is not known. The objectives of this study were to investigate the developmental and hormonal regulation of MIR221 expression in granulosa and theca cells and its possible role in regulating follicular function...
January 29, 2018: Journal of Animal Science
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