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https://www.readbyqxmd.com/read/28629884/-evaluation-of-mortality-after-the-analysis-of-the-screening-history-in-women-diagnosed-with-infiltrating-cervical-cancer
#1
Marta Castillo, Aurora Astudillo, Omar Clavero, Julio Velasco, Raquel Ibáñez, Silvia de Sanjosé
OBJECTIVE: To assess the impact of screening history on the incidence of cervical cancer from 2000 to 2010 in Asturias. DESIGN: Retrospective study. LOCATION: All public hospitals in Asturias. MEAN MEASUREMENTS: From 374 women diagnosed with cervical cancer were retrieved. Clinical information, FIGO stage and all previous cytological data were extracted from clinical and histopathological records. Proportional differences were assessed using chi-square tests...
June 16, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28611733/helicobacter-pylori-antibody-reactivities-and-colorectal-cancer-risk-in-a-case-control-study-in-spain
#2
Nerea Fernández de Larrea-Baz, Angelika Michel, Beatriz Romero, Beatriz Pérez-Gómez, Victor Moreno, Vicente Martín, Trinidad Dierssen-Sotos, José J Jiménez-Moleón, Jesús Castilla, Adonina Tardón, Irune Ruiz, Rosana Peiró, Antonio Tejada, María D Chirlaque, Julia A Butt, Rocío Olmedo-Requena, Inés Gómez-Acebo, Pedro Linares, Elena Boldo, Antoni Castells, Michael Pawlita, Gemma Castaño-Vinyals, Manolis Kogevinas, Silvia de Sanjosé, Marina Pollán, Rosa Del Campo, Tim Waterboer, Nuria Aragonés
Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain. Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28604886/antihypertensive-and-antioxidant-effects-of-supplementation-with-red-wine-pomace-in-spontaneously-hypertensive-rats
#3
Raquel Del Pino-García, María D Rivero-Pérez, María L González-SanJosé, Kevin D Croft, Pilar Muñiz
Hypertension is associated with enhanced vascular oxidative stress and impaired endothelial function, which is related to an imbalance between reactive oxygen species and nitric oxide bioavailability. Short-term supplementation with a polyphenol-rich powdered red wine pomace seasoning (RWPS) was investigated for its effects on blood pressure and biomarkers of endothelial dysfunction and oxidative status in a model of essential hypertension. Male spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto rats (12-week-old, 5 rats per group) were administered RWPS (300 mg kg(-1) day(-1); equivalent to 7...
June 12, 2017: Food & Function
https://www.readbyqxmd.com/read/28586128/capturing-elusive-cobaltacycle-intermediates-a-real-time-snapshot-of-the-cp-co-iii-catalyzed-oxidative-alkyne-annulation
#4
Jesús Sanjosé-Orduna, Daniel Gallego, Alèria Garcia-Roca, Eddy Martin, Jordi Benet-Buchholz, Monica Helvia Perez-Temprano
Despite Cp*Co(III) catalysts have emerged as a very attractive alternative to noble transition metals for the construction of heterocyclic scaffolds via C-H activation, the structure of the reactive species remains uncertain. Herein, we report the identification and unambiguous characterization of two long-sought cyclometalated Cp*Co(III) complexes which have been proposed as key intermediates in C-H functionalization reactions. The addition of MeCN as a stabilizing ligand plays a crucial role, allowing the access to otherwise highly reactive species...
June 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28541789/primary-prevention-of-cervical-cancer-american-society-of-clinical-oncology-resource-stratified-guideline-summary
#5
Silvia de Sanjosé, Sarah Temin, Suzanne Garland, Linda O'Neal Eckert, Silvina Arrossi
No abstract text is available yet for this article.
May 25, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28400857/estimation-of-the-overall-burden-of-cancers-precancerous-lesions-and-genital-warts-attributable-to-9-valent-hpv-vaccine-types-in-women-and-men-in-europe
#6
Susanne Hartwig, Jean Lacau St Guily, Géraldine Dominiak-Felden, Laia Alemany, Silvia de Sanjosé
BACKGROUND: In addition to cervical cancer, human papillomavirus (HPV) is responsible for a significant proportion of cancers and precancerous lesions of the vulva, vagina, anus, penis, head and neck, as well as genital warts. We estimated the annual number of new cases of these diseases attributable to 9-valent HPV vaccine types in women and men in Europe. METHODS: The annual number of new cancers of the cervix, vulva, vagina, anus, penis, and selected head and neck sites in the population of the European Medicines Agency territory was estimated based on age-specific incidence rates extracted from Cancer Incidence in 5 Continents, Volume X and Eurostat population data for 2015...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28380695/adherence-to-nutrition-based-cancer-prevention-guidelines-and-breast-prostate-and-colorectal-cancer-risk-in-the-mcc-spain-case-control-study
#7
Dora Romaguera, Esther Gracia-Lavedan, Amaia Molinuevo, Jordi de Batlle, Michelle Mendez, Victor Moreno, Carmen Vidal, Adela Castelló, Beatriz Pérez-Gómez, Vicente Martín, Antonio J Molina, Verónica Dávila-Batista, Trinidad Dierssen-Sotos, Inés Gómez-Acebo, Javier Llorca, Marcela Guevara, Jesús Castilla, Carmen Urtiaga, Cristóbal Llorens-Ivorra, Guillermo Fernández-Tardón, Adonina Tardón, José Andrés Lorca, Rafael Marcos-Gragera, José María Huerta, Rocío Olmedo-Requena, José Juan Jimenez-Moleon, Jone Altzibar, Silvia de Sanjosé, Marina Pollán, Núria Aragonés, Gemma Castaño-Vinyals, Manolis Kogevinas, Pilar Amiano
Prostate, breast and colorectal cancer are the most common tumours in Spain. The aim of the present study was to evaluate the association between adherence to nutrition-based guidelines for cancer prevention and prostate, breast and colorectal cancer, in the MCC-Spain case-control study. A total of 1,718 colorectal, 1,343 breast and 864 prostate cancer cases and 3,431 population-based controls recruited between 2007 and 2012, were included in the present study. The World Cancer Research Fund/American Institute for Cancer Research (WCRC/AICR) score based on six recommendations for cancer prevention (on body fatness, physical activity, foods and drinks that promote weight gain, plant foods, animal foods and alcoholic drinks; score range 0-6) was constructed...
April 5, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28376081/human-papillomavirus-16-is-an-aetiological-factor-of-scrotal-cancer
#8
Núria Guimerà, Laia Alemany, Gordana Halec, Michael Pawlita, Gerard Vincent Wain, José Santos Salas Vailén, Jerome E Azike, David Jenkins, Silvia de Sanjosé, Wim Quint, F Xavier Bosch
BACKGROUND: Squamous cell scrotal carcinoma (SCSC) is an infrequent skin cancer associated historically with occupational carcinogens. Human papillomavirus (HPV) DNA has been associated with SCSC but there is no definitive proof of its oncogenic role. METHODS: Human papillomavirus-DNA and -E6*I mRNA were analysed in six invasive histologically typed SCSC. LCM-PCR was used to localise HPV DNA to tumour cells. P16(INK4a)and p53 expression were studied by immunohistochemistry...
April 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28369859/role-of-mucosal-high-risk-human-papillomavirus-types-in-head-and-neck-cancers-in-central-india
#9
Tarik Gheit, Devasena Anantharaman, Dana Holzinger, Laia Alemany, Sara Tous, Eric Lucas, Priya Ramesh Prabhu, Michael Pawlita, Ruediger Ridder, Susanne Rehm, Johannes Bogers, Fausto Maffini, Susanna Chiocca, Belén Lloveras, Rekha Vijay Kumar, Thara Somanathan, Silvia de Sanjosé, Xavier Castellsagué, Marc Arbyn, Paul Brennan, Rengaswamy Sankaranarayanan, Madhavan Radhakrishna Pillai, Nitin Gangane, Massimo Tommasino
Mucosal high-risk (HR) human papillomaviruses (HPV) cause a subset of head and neck cancers (HNC). The HPV-attributable fraction of HNC varies substantially between countries. Although HNC has a very high incidence in the Indian subcontinent, information on the contribution of HPV infection is limited. Here, we evaluated the HPV-attributable fraction in HNC (N = 364) collected in a central region of India. HNC from three different anatomical subsites were included, namely, oral cavity (n = 252), oropharynx (n = 53) and hypopharynx/larynx (n = 59)...
March 29, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28291123/medullary-carcinoma-of-the-penis-a-distinctive-hpv-related-neoplasm-a-report-of-12-cases
#10
Sofía Cañete-Portillo, Omar Clavero, Diego F Sanchez, Arturo Silvero, Francisco Abed, Ingrid M Rodriguez, Gustavo Ayala, Laia Alemany, Nubia Munoz, Silvia de Sanjose, Wim Quint, Francesc X Bosch, Antonio L Cubilla
A third to half of penile invasive squamous cell carcinomas are human papillomavirus (HPV) related. Warty (condylomatous), warty-basaloid, and basaloid carcinomas are the most common subtypes associated with HPV. Less frequent are clear cell and lymphoepithelioma-like carcinomas. Here we report a novel penile tumor associated with HPV. Twelve cases were selected from 1010 penile carcinomas, part of an international HPV detection study conducted at the Institut Català d'Oncologia, Barcelona, Spain. Immunostaining with p16 was performed on all cases, and HPV-mRNA detection was also performed...
April 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28274411/alternative-natural-seasoning-to-improve-the-microbial-stability-of-low-salt-beef-patties
#11
Javier García-Lomillo, M A Luisa González-SanJosé, Raquel Del Pino-García, M A Dolores Rivero-Pérez, Pilar Muñiz-Rodríguez
The meat industry is seeking new strategies to reduce the sodium content of meat products without shortening their shelf-life. Natural seasonings as salt alternatives are more appreciated than chemical preservatives and also enable the incorporation of interesting nutrients. The present work studies the potential of a new red wine pomace seasoning (RWPS), derived from wine pomace, to inhibit spoilage growth in beef patties with different salt levels (2%, 1.5% and 1%) held in storage at 4°C. The use of RWPS (2% w/w) improved the microbial stability of the patties, delaying total aerobic mesophilic, and lactic acid bacteria growth, especially in samples with low salt levels...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28223430/young-adult-and-usual-adult-body-mass-index-and-multiple-myeloma-risk-a-pooled-analysis-in-the-international-multiple-myeloma-consortium-immc
#12
Brenda M Birmann, Gabriella Andreotti, Anneclaire J De Roos, Nicola J Camp, Brian C H Chiu, John J Spinelli, Nikolaus Becker, Véronique Benhaim-Luzon, Parveen Bhatti, Paolo Boffetta, Paul Brennan, Elizabeth E Brown, Pierluigi Cocco, Laura Costas, Wendy Cozen, Silvia de Sanjosé, Lenka Foretová, Graham G Giles, Marc Maynadié, Kirsten Moysich, Alexandra Nieters, Anthony Staines, Guido Tricot, Dennis Weisenburger, Yawei Zhang, Dalsu Baris, Mark P Purdue
Background: Multiple myeloma risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with multiple myeloma. We undertook a pooled analysis of eight case-control studies to further evaluate anthropometric multiple myeloma risk factors, including young adult BMI.Methods: We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 multiple myeloma cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for 1,164 cases and 3,629 controls...
June 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28196467/cost-effectiveness-of-strategies-to-increase-screening-coverage-for-cervical-cancer-in-spain-the-criverva-study
#13
Marta Trapero-Bertran, Amelia Acera Pérez, Silvia de Sanjosé, Josep Maria Manresa Domínguez, Diego Rodríguez Capriles, Ana Rodriguez Martinez, Josep Maria Bonet Simó, Norman Sanchez Sanchez, Pablo Hidalgo Valls, Mireia Díaz Sanchis
BACKGROUND: The aim of the study is to carry out a cost-effectiveness analysis of three different interventions to promote the uptake of screening for cervical cancer in general practice in the county of Valles Occidental, Barcelona, Spain. METHODS: Women aged from 30 to 70 years (n = 15,965) were asked to attend a general practice to be screened. They were randomly allocated to one of four groups: no intervention group (NIG); one group where women received an invitation letter to participate in the screening (IG1); one group where women received an invitation letter and informative leaflet (IG2); and one group where women received an invitation letter, an informative leaflet and a phone call reminder (IG3)...
February 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28187495/differential-hpv16-variant-distribution-in-squamous-cell-carcinoma-adenocarcinoma-and-adenosquamous-cell-carcinoma
#14
S Nicolás-Párraga, L Alemany, S de Sanjosé, F X Bosch, I G Bravo
Human Papillomavirus 16 (HPV16) causes 70% of invasive cervical cancers (ICC) worldwide. Interaction between HPV16 genetic diversity, host genetics and target tissue largely determine the chances to trigger carcinogenesis. We have analyzed the differential prevalence of viral variants in 233 HPV16-monoinfected squamous (SCC), glandular (ADC) and mixed (ADSC) ICCs from four continents, assessing the contribution of geographical origin and cancer histology. We have further quantified the contribution of viral variants and cancer histology to differences in age at tumor diagnosis...
May 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28165464/genome-wide-association-analysis-implicates-dysregulation-of-immunity-genes-in-chronic-lymphocytic-leukaemia
#15
Philip J Law, Sonja I Berndt, Helen E Speedy, Nicola J Camp, Georgina P Sava, Christine F Skibola, Amy Holroyd, Vijai Joseph, Nicola J Sunter, Alexandra Nieters, Silvia Bea, Alain Monnereau, David Martin-Garcia, Lynn R Goldin, Guillem Clot, Lauren R Teras, Inés Quintela, Brenda M Birmann, Sandrine Jayne, Wendy Cozen, Aneela Majid, Karin E Smedby, Qing Lan, Claire Dearden, Angela R Brooks-Wilson, Andrew G Hall, Mark P Purdue, Tryfonia Mainou-Fowler, Claire M Vajdic, Graham H Jackson, Pierluigi Cocco, Helen Marr, Yawei Zhang, Tongzhang Zheng, Graham G Giles, Charles Lawrence, Timothy G Call, Mark Liebow, Mads Melbye, Bengt Glimelius, Larry Mansouri, Martha Glenn, Karen Curtin, W Ryan Diver, Brian K Link, Lucia Conde, Paige M Bracci, Elizabeth A Holly, Rebecca D Jackson, Lesley F Tinker, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Marc Maynadie, James McKay, Demetrius Albanes, Stephanie Weinstein, Zhaoming Wang, Neil E Caporaso, Lindsay M Morton, Richard K Severson, Elio Riboli, Paolo Vineis, Roel C H Vermeulen, Melissa C Southey, Roger L Milne, Jacqueline Clavel, Sabine Topka, John J Spinelli, Peter Kraft, Maria Grazia Ennas, Geoffrey Summerfield, Giovanni M Ferri, Robert J Harris, Lucia Miligi, Andrew R Pettitt, Kari E North, David J Allsup, Joseph F Fraumeni, James R Bailey, Kenneth Offit, Guy Pratt, Henrik Hjalgrim, Chris Pepper, Stephen J Chanock, Chris Fegan, Richard Rosenquist, Silvia de Sanjose, Angel Carracedo, Martin J S Dyer, Daniel Catovsky, Elias Campo, James R Cerhan, James M Allan, Nathanial Rothman, Richard Houlston, Susan Slager
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10(-13)), 1q42.13 (rs41271473, P=1.06 × 10(-10)), 4q24 (rs71597109, P=1.37 × 10(-10)), 4q35.1 (rs57214277, P=3...
February 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28118410/increasing-cervical-cancer-screening-coverage-a-randomised-community-based-clinical-trial
#16
Amelia Acera, Josep Maria Manresa, Diego Rodriguez, Ana Rodriguez, Josep Maria Bonet, Marta Trapero-Bertran, Pablo Hidalgo, Norman Sànchez, Silvia de Sanjosé
BACKGROUND: Opportunistic cervical cancer screening can lead to suboptimal screening coverage. Coverage could be increased after a personalised invitation to the target population. We present a community randomized intervention study with three strategies aiming to increase screening coverage. METHODS: The CRICERVA study is a community-based clinical trial to improve coverage of population-based screening in the Cerdanyola SAP area in Barcelona.A total of 32,858 women residing in the study area, aged 30 to 70 years were evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/28113037/small-ruminant-lentiviruses-in-sheep-pathology-and-tropism-of-2-strains-using-the-bone-marrow-route
#17
P Pinczowski, L Sanjosé, M Gimeno, H Crespo, I Glaria, B Amorena, D de Andrés, M Pérez, R Reina, L Luján
The objective of this work was to comparatively study the tissue tropism and the associated pathology of 2 autochthonous small ruminant lentivirus (SRLV) field strains using an experimental infection in sheep through the bone marrow. Fifteen male, SRLV-free lambs of the Rasa Aragonesa breed were inoculated with strain 697 (nervous tissue origin, animals A1-A6), with strain 496 (articular origin, animals B1-B6), or with uninfected culture medium (C1-C3). Clinical, serologic, and polymerase chain reaction (PCR) evaluations were performed periodically...
May 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28059099/biological-relevance-of-human-papillomaviruses-in-vulvar-cancer
#18
Gordana Halec, Laia Alemany, Beatriz Quiros, Omar Clavero, Daniela Höfler, Maria Alejo, Wim Quint, Michael Pawlita, Francesc X Bosch, Silvia de Sanjose
The carcinogenic role of high-risk human papillomavirus (HR-HPV) types in the increasing subset of vulvar intraepithelial neoplasia and vulvar cancer in young women has been established. However, the actual number of vulvar cancer cases attributed to HPV is still imprecisely defined. In an attempt to provide a more precise definition of HPV-driven vulvar cancer, we performed HPV-type-specific E6*I mRNA analyses available for 20 HR-/possible HR (pHR)-HPV types, on tissue samples from 447 cases of vulvar cancer...
April 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27979153/the-effects-of-heat-treatment-on-the-phenolic-composition-and-antioxidant-capacity-of-red-wine-pomace-seasonings
#19
Raquel Del Pino-García, María L González-SanJosé, María D Rivero-Pérez, Javier García-Lomillo, Pilar Muñiz
The impact of thermal processing on the phenolic profile and antioxidant capacity (TAC) of powdered red wine pomace seasonings (RWPSs) obtained from different sources (seedless: Sk-S; whole: W-S; seeds: Sd-S) was assessed. High contents in anthocyanins, flavonol-3-O-glycosides, phenolic acids and flavan-3-ols were found in Sk-S, whereas flavan-3-ols and phenolic acids were the main compounds identified in Sd-S. Reductions in the anthocyanidin and flavonol-3-ol contents mainly determined the effect of heat on the total phenolic contents (Sk-S: -29...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27957845/chemopreventive-potential-of-powdered-red-wine-pomace-seasonings-against-colorectal-cancer-in-ht-29-cells
#20
Raquel Del Pino-García, María D Rivero-Pérez, María L González-SanJosé, Miriam Ortega-Heras, Javier García Lomillo, Pilar Muñiz
This study evaluates the antiproliferative and antigenotoxic actions of powdered red wine pomace seasonings (Sk-S, seedless; W-S, whole; Sd-S, seeds). In vitro gastrointestinal digested and colonic fermented fractions of the seasonings were used as cell treatments. Phenolic acids from Sk-S showed the highest bioaccessibility in the small intestine, whereas polyphenols contained in Sd-S might be the most fermentable in the colon. Dietary fiber from Sk-S was the best substrate for short chain fatty acids production by gut microbiota...
January 11, 2017: Journal of Agricultural and Food Chemistry
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