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Raquel Del Pino-García, María D Rivero-Pérez, María L González-SanJosé, Pablo Castilla-Camina, Kevin D Croft, Pilar Muñiz
Type 1 diabetes mellitus (DM) is characterized by hyperglycemia resulting from insulin deficiency. This is usually accompanied by a pro-oxidative environment, dyslipidemia and endothelial dysfunction, thus leading to several micro- and macro-vascular complications. This study investigated the potential benefits of a seasoning obtained from seedless red wine pomace (RWPS) in protecting against oxidative damage and preserving endothelial function in Type 1 DM, and the underlying mechanisms involved at the level of gene expression...
October 12, 2016: Food & Function
Marta Félez-Sánchez, Marleny Vergara, Silvia de Sanjosé, Xavier Castellsagué, Laia Alemany, Ignacio G Bravo
Human Papillomaviruses (HPVs) are involved in the etiology of anogenital and head and neck cancers. The HPV DNA prevalence greatly differs by anatomical site. Indeed, the high rates of viral DNA prevalence in anal and cervical carcinomas contrast with the lower fraction of cancer cases attributable to HPVs in other anatomical sites, chiefly the vulva, the penis and head and neck. Here we analyzed 2635 Formalin Fixed Paraffin Embedded surgical samples that had previously tested negative for the presence of HPVs DNA using the SPF10/DEIA procedure, in order to identify the presence of other PVs not explicitly targeted by standard molecular epidemiologic approaches...
September 4, 2016: Infection, Genetics and Evolution
Marta Castillo, Aurora Astudillo, Omar Clavero, Julio Velasco, Raquel Ibáñez, Silvia de Sanjosé
OBJECTIVE: The objective of this study was to describe prior negative screening history and symptoms around the time of diagnosis of incident cervical cancer (CC) cases diagnosed between 2000 and 2010 within the Asturias public health system. METHODS: Records from 374 women diagnosed with CC between 2000 and 2010 from all public hospitals in Asturias were retrieved. Clinical information, FIGO stage and all previous cytological data were extracted from clinical and histopathological records...
2016: PloS One
Mayte Martín-Bustamante, Anna Oliete-Canela, Marta Diéguez-Rodríguez, Yolanda Benavente, Delphine Casabonne, Juan Alguacil, Manolis Kogevinas, Silvia de Sanjosé, Laura Costas
OBJECTIVES: Our aim was to develop a job-exposure matrix (JEM) to assess occupational exposure to alkylphenolic compounds in epidemiological research, considering changes in their use over time, and including exposure probabilities in the assessments. METHODS: We consulted multiple sources of information, and performed interviews with 9 key people from industry and academia. 3 hygienists coded frequency (minority or majority of workers involved) and intensity of exposure (including dispersive processes, with shaking, or aerosol generation, or otherwise) to alkylphenolic compounds for all the 390 International Standard Classification of Occupations (ISCO)-88 job titles by period of time...
August 18, 2016: Occupational and Environmental Medicine
Asif Loya, Beatriz Serrano, Farah Rasheed, Sara Tous, Mariam Hassan, Omar Clavero, Muhammad Raza, Silvia De Sanjosé, F Xavier Bosch, Laia Alemany
Few studies have assessed the burden of human papillomavirus (HPV) infection in Pakistan. We aim to provide specific information on HPV-type distribution in invasive cervical cancer (ICC) in the country. A total of 280 formalin-fixed paraffin-embedded tissue blocks were consecutively selected from Shaukat Khanum Memorial Cancer Hospital and Research Centre (Lahore, Pakistan). HPV-DNA was detected by SPF10 broad-spectrum PCR followed by DNA enzyme immunoassay and genotyping by LiPA25. HPV-DNA prevalence was 87...
2016: Cancers
Laura Costas, Yolanda Benavente, Rocío Olmedo-Requena, Delphine Casabonne, Claudia Robles, Eva-Maria Gonzalez-Barca, Esmeralda de la Banda, Esther Alonso, Marta Aymerich, Adonina Tardón, Rafael Marcos-Gragera, Eva Gimeno-Vázquez, Inés Gómez-Acebo, Kyriaki Papantoniou, Gemma Castaño-Vinyals, Nuria Aragonés, Marina Pollán, Manolis Kogevinas, Silvia de Sanjosé
Chronic lymphocytic leukemia (CLL) has few known modifiable risk factors. Recently, circadian disruption has been proposed as a potential contributor to lymphoid neoplasms' etiology. Serum melatonin levels have been found to be significantly lower in CLL subjects compared with healthy controls, and also, CLL prognosis has been related to alterations in the circadian molecular signaling. We performed the first investigation of an association between night shift work and CLL in 321 incident CLL cases and 1728 population-based controls in five areas of Spain...
November 1, 2016: International Journal of Cancer. Journal International du Cancer
Laia Bruni, Mireia Diaz, Leslie Barrionuevo-Rosas, Rolando Herrero, Freddie Bray, F Xavier Bosch, Silvia de Sanjosé, Xavier Castellsagué
BACKGROUND: Since 2006, many countries have implemented publicly funded human papillomavirus (HPV) immunisation programmes. However, global estimates of the extent and impact of vaccine coverage are still unavailable. We aimed to quantify worldwide cumulative coverage of publicly funded HPV immunisation programmes up to 2014, and the potential impact on future cervical cancer cases and deaths. METHODS: Between Nov 1 and Dec 22, 2014, we systematically reviewed PubMed, Scopus, and official websites to identify HPV immunisation programmes worldwide, and retrieved age-specific HPV vaccination coverage rates up to October, 2014...
July 2016: Lancet Global Health
Marianna Karachaliou, Leda Chatzi, Theano Roumeliotaki, Mariza Kampouri, Andriani Kyriklaki, Katerina Koutra, Georgia Chalkiadaki, Angelika Michel, Eftichia Stiakaki, Manolis Kogevinas, Michael Pawlita, Tim Waterboer, Silvia de Sanjose
BACKGROUND: Viral infections of the central nervous system may have detrimental effects for the developing brain, but the effects of less virulent common infections are unclear. We aim to investigate the impact of common viral infections of early childhood on neuropsychological performance of children at age four. METHODS: We used cross-sectional data on 674 children participating at the 4 years of age follow-up of the Rhea birth cohort in Crete, Greece. Blood levels of IgG antibodies to 10 polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses [Epstein-Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1), and herpes simplex virus-2 (HSV-2)] were measured using multiplex serology...
June 23, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Leah H Schinasi, Elizabeth E Brown, Nicola J Camp, Sophia S Wang, Jonathan N Hofmann, Brian C Chiu, Lucia Miligi, Laura E Beane Freeman, Silvia de Sanjose, Leslie Bernstein, Alain Monnereau, Jacqueline Clavel, Guido J Tricot, Djordje Atanackovic, Pierluigi Cocco, Laurent Orsi, James A Dosman, John R McLaughlin, Mark P Purdue, Wendy Cozen, John J Spinelli, Anneclaire J de Roos
Family clusters of multiple myeloma (MM) suggest disease heritability. Nevertheless, patterns of inheritance and the importance of genetic versus environmental risk factors in MM aetiology remain unclear. We pooled data from eleven case-control studies from the International Multiple Myeloma Consortium to characterize the association of MM risk with having a first-degree relative with a history of a lympho-haematapoietic cancer. Unconditional logistic regression models, adjusted for study, sex, age and education level, were used to estimate associations between MM risk and having a first-degree relative with a history of non-Hodgkin lymphoma, Hodgkin lymphoma, leukaemia or MM...
October 2016: British Journal of Haematology
Raquel Del Pino-García, María L González-SanJosé, María D Rivero-Pérez, Javier García-Lomillo, Pilar Muñiz
New powdered seasonings, rich in natural antioxidant compounds, have successfully been applied recently in different food matrices. Once ingested, the antioxidants contained in these seasonings may exert protective effects against oxidative stress along the gastrointestinal tract. This fact was evaluated by submitting the different seasonings under study to simulated digestion followed by assessing the reducing and antiradical capacities of the digested fractions. Enzymatic gastrointestinal digestion enhanced 2-3 times both antioxidant activities and colonic fermentation increased more than 10-fold the radical scavenging ability of digested fractions compared with undigested seasonings...
November 15, 2016: Food Chemistry
Laure Blatti-Cardinaux, Leticia Sanjosé, Marie-Luise Zahno, Reto Zanoni, Ramses Reina, Giuseppe Bertoni
In spite of an eradication campaign that eliminated clinical cases of caprine arthritis encephalitis virus-induced arthritis in the Swiss goat population, seroconversions are still observed. In the affected flocks, viruses belonging mainly to the small ruminant lentivirus A4 subtype are regularly isolated. These viruses are considered attenuated, except in the mammary gland, where high viral loads and histopathological lesions have been observed. We previously characterized and sequenced such field isolates, detecting several potentially attenuating mutations in their LTR...
July 2016: Journal of General Virology
Mitchell J Machiela, Qing Lan, Susan L Slager, Roel C H Vermeulen, Lauren R Teras, Nicola J Camp, James R Cerhan, John J Spinelli, Sophia S Wang, Alexandra Nieters, Joseph Vijai, Meredith Yeager, Zhaoming Wang, Hervé Ghesquières, James McKay, Lucia Conde, Paul I W de Bakker, David G Cox, Laurie Burdett, Alain Monnereau, Christopher R Flowers, Anneclaire J De Roos, Angela R Brooks-Wilson, Graham G Giles, Mads Melbye, Jian Gu, Rebecca D Jackson, Eleanor Kane, Mark P Purdue, Claire M Vajdic, Demetrius Albanes, Rachel S Kelly, Mariagrazia Zucca, Kimberly A Bertrand, Anne Zeleniuch-Jacquotte, Charles Lawrence, Amy Hutchinson, Degui Zhi, Thomas M Habermann, Brian K Link, Anne J Novak, Ahmet Dogan, Yan W Asmann, Mark Liebow, Carrie A Thompson, Stephen M Ansell, Thomas E Witzig, Hervé Tilly, Corinne Haioun, Thierry J Molina, Henrik Hjalgrim, Bengt Glimelius, Hans-Olov Adami, Göran Roos, Paige M Bracci, Jacques Riby, Martyn T Smith, Elizabeth A Holly, Wendy Cozen, Patricia Hartge, Lindsay M Morton, Richard K Severson, Lesley F Tinker, Kari E North, Nikolaus Becker, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, Anthony Staines, Tracy Lightfoot, Simon Crouch, Alex Smith, Eve Roman, W Ryan Diver, Kenneth Offit, Andrew Zelenetz, Robert J Klein, Danylo J Villano, Tongzhang Zheng, Yawei Zhang, Theodore R Holford, Jenny Turner, Melissa C Southey, Jacqueline Clavel, Jarmo Virtamo, Stephanie Weinstein, Elio Riboli, Paolo Vineis, Rudolph Kaaks, Heiner Boeing, Anne Tjønneland, Emanuele Angelucci, Simonetta Di Lollo, Marco Rais, Immaculata De Vivo, Edward Giovannucci, Peter Kraft, Jinyan Huang, Baoshan Ma, Yuanqing Ye, Brian C H Chiu, Liming Liang, Ju-Hyun Park, Charles C Chung, Dennis D Weisenburger, Joseph F Fraumeni, Gilles Salles, Martha Glenn, Lisa Cannon-Albright, Karen Curtin, Xifeng Wu, Karin E Smedby, Silvia de Sanjose, Christine F Skibola, Sonja I Berndt, Brenda M Birmann, Stephen J Chanock, Nathaniel Rothman
Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms...
April 15, 2016: Human Molecular Genetics
Pouya Khankhanian, Wendy Cozen, Daniel S Himmelstein, Lohith Madireddy, Lennox Din, Anke van den Berg, Takuya Matsushita, Sally L Glaser, Jayaji M Moré, Karin E Smedby, Sergio E Baranzini, Thomas M Mack, Antoine Lizée, Silvia de Sanjosé, Pierre-Antoine Gourraud, Alexandra Nieters, Stephen L Hauser, Pierluigi Cocco, Marc Maynadié, Lenka Foretová, Anthony Staines, Manon Delahaye-Sourdeix, Dalin Li, Smita Bhatia, Mads Melbye, Kenan Onel, Ruth Jarrett, James D McKay, Jorge R Oksenberg, Henrik Hjalgrim
BACKGROUND: Based on epidemiological commonalities, multiple sclerosis (MS) and Hodgkin lymphoma (HL), two clinically distinct conditions, have long been suspected to be aetiologically related. MS and HL occur in roughly the same age groups, both are associated with Epstein-Barr virus infection and ultraviolet (UV) light exposure, and they cluster mutually in families (though not in individuals). We speculated if in addition to sharing environmental risk factors, MS and HL were also genetically related...
June 2016: International Journal of Epidemiology
Marianna Karachaliou, Tim Waterboer, Delphine Casabonne, Georgia Chalkiadaki, Theano Roumeliotaki, Angelika Michel, Eftichia Stiakaki, Leda Chatzi, Michael Pawlita, Manolis Kogevinas, Silvia de Sanjose
Sparse data exist on the patterns and determinants of acquisition of polyomaviruses and herpesviruses in childhood. We measured immunoglobulin G seroreactivity against 10 polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, MCPyV, HPyV6, HPyV7, TSPyV, HPyV9, HPyV10) and 5 herpesviruses (Epstein Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus types 1 and 2, human herpesvirus 8) using multiplex serology on blood samples collected at birth (cord blood, n = 626) and at follow-up at 3 years (n = 81) and 4 years (n = 690) of age among the Rhea birth cohort recruited in Greece from pregnant women in 2007-2008...
April 1, 2016: American Journal of Epidemiology
Patricia Batres-Mendoza, Carlos R Montoro-Sanjose, Erick I Guerra-Hernandez, Dora L Almanza-Ojeda, Horacio Rostro-Gonzalez, Rene J Romero-Troncoso, Mario A Ibarra-Manzano
Quaternions can be used as an alternative to model the fundamental patterns of electroencephalographic (EEG) signals in the time domain. Thus, this article presents a new quaternion-based technique known as quaternion-based signal analysis (QSA) to represent EEG signals obtained using a brain-computer interface (BCI) device to detect and interpret cognitive activity. This quaternion-based signal analysis technique can extract features to represent brain activity related to motor imagery accurately in various mental states...
2016: Sensors
Sonja I Berndt, Nicola J Camp, Christine F Skibola, Joseph Vijai, Zhaoming Wang, Jian Gu, Alexandra Nieters, Rachel S Kelly, Karin E Smedby, Alain Monnereau, Wendy Cozen, Angela Cox, Sophia S Wang, Qing Lan, Lauren R Teras, Moara Machado, Meredith Yeager, Angela R Brooks-Wilson, Patricia Hartge, Mark P Purdue, Brenda M Birmann, Claire M Vajdic, Pierluigi Cocco, Yawei Zhang, Graham G Giles, Anne Zeleniuch-Jacquotte, Charles Lawrence, Rebecca Montalvan, Laurie Burdett, Amy Hutchinson, Yuanqing Ye, Timothy G Call, Tait D Shanafelt, Anne J Novak, Neil E Kay, Mark Liebow, Julie M Cunningham, Cristine Allmer, Henrik Hjalgrim, Hans-Olov Adami, Mads Melbye, Bengt Glimelius, Ellen T Chang, Martha Glenn, Karen Curtin, Lisa A Cannon-Albright, W Ryan Diver, Brian K Link, George J Weiner, Lucia Conde, Paige M Bracci, Jacques Riby, Donna K Arnett, Degui Zhi, Justin M Leach, Elizabeth A Holly, Rebecca D Jackson, Lesley F Tinker, Yolanda Benavente, Núria Sala, Delphine Casabonne, Nikolaus Becker, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, James McKay, Anthony Staines, Kari G Chaffee, Sara J Achenbach, Celine M Vachon, Lynn R Goldin, Sara S Strom, Jose F Leis, J Brice Weinberg, Neil E Caporaso, Aaron D Norman, Anneclaire J De Roos, Lindsay M Morton, Richard K Severson, Elio Riboli, Paolo Vineis, Rudolph Kaaks, Giovanna Masala, Elisabete Weiderpass, María-Dolores Chirlaque, Roel C H Vermeulen, Ruth C Travis, Melissa C Southey, Roger L Milne, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Jacqueline Clavel, Tongzhang Zheng, Theodore R Holford, Danylo J Villano, Ann Maria, John J Spinelli, Randy D Gascoyne, Joseph M Connors, Kimberly A Bertrand, Edward Giovannucci, Peter Kraft, Anne Kricker, Jenny Turner, Maria Grazia Ennas, Giovanni M Ferri, Lucia Miligi, Liming Liang, Baoshan Ma, Jinyan Huang, Simon Crouch, Ju-Hyun Park, Nilanjan Chatterjee, Kari E North, John A Snowden, Josh Wright, Joseph F Fraumeni, Kenneth Offit, Xifeng Wu, Silvia de Sanjose, James R Cerhan, Stephen J Chanock, Nathaniel Rothman, Susan L Slager
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3...
2016: Nature Communications
Esther Roura, Noémie Travier, Tim Waterboer, Silvia de Sanjosé, F Xavier Bosch, Michael Pawlita, Valeria Pala, Elisabete Weiderpass, Núria Margall, Joakim Dillner, Inger T Gram, Anne Tjønneland, Christian Munk, Domenico Palli, Kay-Tee Khaw, Kim Overvad, Françoise Clavel-Chapelon, Sylvie Mesrine, Agnès Fournier, Renée T Fortner, Jennifer Ose, Annika Steffen, Antonia Trichopoulou, Pagona Lagiou, Philippos Orfanos, Giovanna Masala, Rosario Tumino, Carlotta Sacerdote, Silvia Polidoro, Amalia Mattiello, Eiliv Lund, Petra H Peeters, H B As Bueno-de-Mesquita, J Ramón Quirós, María-José Sánchez, Carmen Navarro, Aurelio Barricarte, Nerea Larrañaga, Johanna Ekström, David Lindquist, Annika Idahl, Ruth C Travis, Melissa A Merritt, Marc J Gunter, Sabina Rinaldi, Massimo Tommasino, Silvia Franceschi, Elio Riboli, Xavier Castellsagué
No abstract text is available yet for this article.
2016: PloS One
Katherine E Gallagher, Kathy Baisley, Heiner Grosskurth, Andrew Vallely, Saidi Kapiga, Judith Vandepitte, Anatoli Kamali, Silvia De Sanjosé, John Changalucha, Richard Hayes, Deborah Watson-Jones
OBJECTIVE: This study was performed to analyze the associations between cervical human papillomavirus (HPV) infection and human immunodeficiency virus (HIV) acquisition, using cervical samples from previous studies in Tanzania and Uganda. METHODS: A total of 161 adult women who acquired HIV infection during follow-up and 464 individually matched HIV-seronegative controls were selected from 5 cohorts of women working in bars and recreational facilities. Stored cervical samples were tested for 37 HPV genotypes, using a polymerase chain reaction assay (Roche Linear Array genotyping assay)...
July 1, 2016: Journal of Infectious Diseases
Catherine F Houlihan, Kathy Baisley, Ignacio G Bravo, Saidi Kapiga, Silvia de Sanjosé, John Changalucha, David A Ross, Richard J Hayes, Deborah Watson-Jones
BACKGROUND: No reports exist on genotype-specific human papillomavirus (HPV) acquisition in girls after first sex in sub-Saharan Africa, despite high HPV prevalence and cervical cancer incidence. METHODS: We followed 503 HP-unvaccinated girls aged 15-16 years in Mwanza, Tanzania, 3-monthly for 18 months with interviews and self-administered vaginal swabs. Swabs were tested for 13 higHRisk and 24 low-risk HPV genotypes. Incidence, clearance and duration of overall HPV and genotype-specific infections were calculated and associated factors evaluated...
June 2016: International Journal of Epidemiology
Carmen H Puga, Belen Orgaz, Carmen SanJose
Changes in spatial organization, as observed by confocal laser scanning microscopy (CLSM), viable cell content, biovolume, and substratum surface coverage of the biofilms formed on glass by Pseudomonas fluorescens resulting from co-culture with Listeria monocytogenes, were examined. Two strains of L. monocytogenes, two culture temperatures and two biofilm developmental stages were investigated. Both L. monocytogenes strains, a persistently sampled isolate (collected repeatedly along 3 years from a meat factory) and Scott A, induced shrinkage in matrix volume, both at 20°C and 4°C, in mature or old biofilms, without loss of P...
2016: Frontiers in Microbiology
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