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https://www.readbyqxmd.com/read/29674426/association-of-polygenic-risk-score-with-the-risk-of-chronic-lymphocytic-leukemia-and-monoclonal-b-cell-lymphocytosis
#1
Geffen Kleinstern, Nicola J Camp, Lynn R Goldin, Celine M Vachon, Claire M Vajdic, Silvia de Sanjose, J Brice Weinberg, Yolanda Benavente, Delphine Casabonne, Mark Liebow, Alexandra Nieters, Henrik Hjalgrim, Mads Melbye, Bengt Glimelius, Hans-Olov Adami, Paolo Boffetta, Paul Brennan, Marc Maynadie, James McKay, Pier Luigi Cocco, Tait D Shanafelt, Timothy G Call, Aaron Norman, Curtis Hanson, Dennis Robinson, Kari G Chaffee, Angela R Brooks-Wilson, Alain Monnereau, Jacqueline Clavel, Martha Glenn, Karen Curtin, Lucia Conde, Paige M Bracci, Lindsay M Morton, Wendy Cozen, Richard K Severson, Stephen J Chanock, John J Spinelli, James B Johnston, Nathaniel Rothman, Christine F Skibola, Jose F Leis, Neil E Kay, Karin E Smedby, Sonja I Berndt, James R Cerhan, Neil Caporaso, Susan L Slager
Inherited loci have been found to be associated with risk of chronic lymphocytic leukemia (CLL). A combined polygenic risk score (PRS) of representative single nucleotide polymorphisms (SNPs) from these loci may improve risk prediction over individual SNPs. Herein, we evaluated the association of a PRS with CLL risk and its precursor, monoclonal B-cell lymphocytosis (MBL). We assessed its validity and discriminative ability in an independent sample and evaluated effect modification and confounding by family history (FH) of hematological cancers...
April 19, 2018: Blood
https://www.readbyqxmd.com/read/29563964/comparative-assessment-of-hpv-alcohol-and-tobacco-etiological-fractions-in-algerian-patients-with-laryngeal-squamous-cell-carcinoma
#2
Nora Kariche, Montserrat Torres Hortal, Samir Benyahia, Laia Alemany, Nabila Moulaï, Omar Clavero, Marleny Muñoz, Wahiba Ouahioune, Djamel Djennaoui, Chafia Touil-Boukoffa, Silvia de Sanjosé, Mehdi Bourouba
Background: Despite the increasing incidence of laryngeal squamous cell carcinoma (LSCC) in Algeria, scarce information is available on the importance of the preventable etiological factors which may drive the disease. Remarkably, a significant number of cases occur in nonsmoker and nondrinker patients; hence, suggesting that alternative risk factors, like Human papillomavirus (HPV), might be etiologically involved. To gain more insight on the risk factors associated with the disease in the country, we evaluated the etiological fraction of HPV in comparison to tobacco and alcohol intake in LSCC patients...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29555602/contribution-of-human-papillomavirus-in-neuroendocrine-tumors-from-a-series-of-10-575-invasive-cervical-cancer-cases
#3
Maria Alejo, Laia Alemany, Omar Clavero, Beatriz Quiros, Susana Vighi, Muhieddine Seoud, Chou Cheng-Yang, Suzanne M Garland, Nuria Juanpere, Josep Lloreta, Sara Tous, Jo Ellen Klaustermeier, Wim Quint, F Xavier Bosch, Silvia de Sanjosé, Belen Lloveras
AIMS: Neuroendocrine tumors (NET) of the cervix are rare tumors with a very aggressive course. The human papillomavirus (HPV) has been linked to its etiology. The objective of this study is to describe HPV prevalence and genotype distribution of NET. METHODS AND RESULTS: Forty-nine tumors with histological neuroendocrine features were identified among 10,575 invasive cervical cancer (ICC) cases from an international study. HPV DNA detection was done using SPF10/DEIA /LiPA25 system...
March 16, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29505429/differentiated-vulvar-intraepithelial-neoplasia-like-and-lichen-sclerosus-like-lesions-in-hpv-associated-squamous-cell-carcinomas-of-the-vulva
#4
Natalia Rakislova, Laia Alemany, Omar Clavero, Marta Del Pino, Adela Saco, Beatriz Quirós, Belen Lloveras, Maria Alejo, Gordana Halec, Wim Quint, Silvia de Sanjosé, Jaume Ordi
Most human papillomavirus (HPV)-associated vulvar squamous cell carcinomas (VSCCs) originate from high-grade squamous intraepithelial lesions, also named usual type vulvar intraepithelial neoplasia. However, growing evidence suggests that morphologic studies have limitations in predicting HPV status in vulvar lesions. We aimed to evaluate adjacent intraepithelial lesions in a series of DNA HPV-positive VSCCs, focusing on unusual histologic patterns mimicking differentiated vulvar intraepithelial neoplasia (dVIN) or lichen sclerosus (LS)...
March 2, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29499389/ipvs-statement-moving-towards-elimination-of-cervical-cancer-as-a-public-health-problem
#5
EDITORIAL
S M Garland, A Giuliano, Jml Brotherton, A B Moscicki, M Stanley, A M Kaufmann, N Bhatla, R Sankaranarayanan, J M Palefsky, S de Sanjose
No abstract text is available yet for this article.
February 27, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29496041/double-positivity-for-hpv-dna-p16-ink4a-is-the-biomarker-with-strongest-diagnostic-accuracy-and-prognostic-value-for-human-papillomavirus-related-oropharyngeal-cancer-patients
#6
Marisa Mena, Miren Taberna, Sara Tous, Sandra Marquez, Omar Clavero, Beatriz Quiros, Belen Lloveras, Maria Alejo, Xavier Leon, Miquel Quer, Silvia Bagué, Ricard Mesia, Julio Nogués, Montserrat Gomà, Anton Aguila, Teresa Bonfill, Carmen Blazquez, Marta Guix, Rafael Hijano, Montserrat Torres, Dana Holzinger, Michael Pawlita, Miguel Angel Pavon, Ignacio G Bravo, Silvia de Sanjosé, Francesc Xavier Bosch, Laia Alemany
BACKGROUND: The etiologic role of human papillomaviruses (HPV) in oropharyngeal cancer (OPC) is well established. Nevertheless, information on survival differences by anatomic sub-site or treatment remains scarce, and it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. METHODS: We conducted a retrospective cohort study of all patients diagnosed with a primary OPC in four Catalonian hospitals from 1990 to 2013. Formalin-fixed, paraffin-embedded cancer tissues were subjected to histopathological evaluation, DNA quality control, HPV-DNA detection, and p16INK4a /pRb/p53/Cyclin-D1 immunohistochemistry...
March 2018: Oral Oncology
https://www.readbyqxmd.com/read/29445241/is-early-life-exposure-to-polyomaviruses-and-herpesviruses-associated-with-obesity-indices-and-metabolic-traits-in-childhood
#7
Marianna Karachaliou, Silvia de Sanjose, Tim Waterboer, Theano Roumeliotaki, Maria Vassilaki, Katerina Sarri, Vasiliki Leventakou, Marina Vafeiadi, Georgia Chalkiadaki, Eftichia Stiakaki, Angelika Michel, Michael Pawlita, Manolis Kogevinas, Leda Chatzi
BACKGROUND: Evidence for an infectious origin of obesity is emerging. We explored whether common viruses were associated with obesity and metabolic traits. METHODS: We used cross-sectional (n = 674) and prospective (n = 440) data from children participating at the 4 and 6 years of age follow-up in the Rhea birth cohort. Presence of IgG antibodies to ten polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses (EBV, CMV, HSV-1, and HSV-2) were measured at age 4...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29289901/established-and-suggested-exposures-on-cll-sll-etiology-results-from-the-cll-mcc-spain-study
#8
Yolanda Benavente, Delphine Casabonne, Laura Costas, Claudia Robles, Esther Alonso, Esmeralda de la Banda, Eva Gonzalez-Barca, Rafael Marcos-Gragera, Javier Llorca, Adonina Tardón, José J Monleon, Marta Aymerich, Elías Campo, Eva Gimeno-Vázquez, Gemma Castaño-Vinyals, Nuria Aragonés, Marina Pollán, Manolis Kogevinas, Sílvia de Sanjosé
INTRODUCTION: Chronic Lymphocytic Leukemia (CLL/SLL) is the most common adult leukemia in Western countries. Although it is mostly an indolent disease it is still incurable and with limited knowledge in relation to its etiology. We aim to confirm and quantify established risk factors for CLL/SLL using a multi-center epidemiological population-based case-control study on CLL/SLL as well as to explore new exposures inconclusively associated with CLL/SLL METHODS: Using the framework provided by the large MCC-Spain case-control study, we explored established and suggested risk factors associated with CLL/SLL using data collected through a face-to-face interview...
February 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29222509/impact-of-model-calibration-on-cost-effectiveness-analysis-of-cervical-cancer-prevention
#9
David Moriña, Silvia de Sanjosé, Mireia Diaz
Markov chain models are commonly used to simulate the natural history of human papillomavirus infection and subsequent cervical lesions with the aim of predicting future benefits of health interventions. Developing and calibrating these models entails making a number of critical decisions that will influence the ability of the model to reflect real conditions and predict future situations. Accuracy of selected inputs and calibration procedures are two of the crucial aspects for model performance and understanding their influence is essential, especially when involves policy decisions...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214033/lupus-related-single-nucleotide-polymorphisms-and-risk-of-diffuse-large-b-cell-lymphoma
#10
Sasha Bernatsky, Héctor A Velásquez García, John J Spinelli, Patrick Gaffney, Karin E Smedby, Rosalind Ramsey-Goldman, Sophia S Wang, Hans-Olov Adami, Demetrius Albanes, Emanuele Angelucci, Stephen M Ansell, Yan W Asmann, Nikolaus Becker, Yolanda Benavente, Sonja I Berndt, Kimberly A Bertrand, Brenda M Birmann, Heiner Boeing, Paolo Boffetta, Paige M Bracci, Paul Brennan, Angela R Brooks-Wilson, James R Cerhan, Stephen J Chanock, Jacqueline Clavel, Lucia Conde, Karen H Cotenbader, David G Cox, Wendy Cozen, Simon Crouch, Anneclaire J De Roos, Silvia de Sanjose, Simonetta Di Lollo, W Ryan Diver, Ahmet Dogan, Lenka Foretova, Hervé Ghesquières, Graham G Giles, Bengt Glimelius, Thomas M Habermann, Corinne Haioun, Patricia Hartge, Henrik Hjalgrim, Theodore R Holford, Elizabeth A Holly, Rebecca D Jackson, Rudolph Kaaks, Eleanor Kane, Rachel S Kelly, Robert J Klein, Peter Kraft, Anne Kricker, Qing Lan, Charles Lawrence, Mark Liebow, Tracy Lightfoot, Brian K Link, Marc Maynadie, James McKay, Mads Melbye, Thierry J Molina, Alain Monnereau, Lindsay M Morton, Alexandra Nieters, Kari E North, Anne J Novak, Kenneth Offit, Mark P Purdue, Marco Rais, Jacques Riby, Eve Roman, Nathaniel Rothman, Gilles Salles, Gianluca Severi, Richard K Severson, Christine F Skibola, Susan L Slager, Alex Smith, Martyn T Smith, Melissa C Southey, Anthony Staines, Lauren R Teras, Carrie A Thompson, Hervé Tilly, Lesley F Tinker, Anne Tjonneland, Jenny Turner, Claire M Vajdic, Roel C H Vermeulen, Joseph Vijai, Paolo Vineis, Jarmo Virtamo, Zhaoming Wang, Stephanie Weinstein, Thomas E Witzig, Andrew Zelenetz, Anne Zeleniuch-Jacquotte, Yawei Zhang, Tongzhang Zheng, Mariagrazia Zucca, Ann E Clarke
Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29179869/overcoming-barriers-in-hpv-vaccination-and-screening-programs
#11
Alex Vorsters, Marc Arbyn, Marc Baay, Xavier Bosch, Silvia de Sanjosé, Sharon Hanley, Emilie Karafillakis, Pier Luigi Lopalco, Kevin G Pollock, Joanne Yarwood, Pierre Van Damme
The Human Papillomavirus Prevention and Control Board brought together experts to discuss optimizing HPV vaccination and screening programs. Board members reviewed the safety profile of licensed HPV vaccines based on clinical and post-marketing data, reaching a consensus that current safety data is reassuring. Successful vaccination programs used well-coordinated communication campaigns, integrating (social) media to spread awareness. Communication of evidence supporting vaccine effectiveness had beneficial effects on the perception of the vaccine...
December 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/29179867/hpv-vaccination-of-immunocompromised-hosts
#12
S M Garland, J M L Brotherton, A B Moscicki, A M Kaufmann, M Stanley, N Bhatla, R Sankaranarayanan, S de Sanjosé, J M Palefsky
It is well-established that immunocompromised people are at increased risk of HPV-related disease compared with those who are immunocompetent. Prophylactic HPV sub-unit vaccines are safe and immunogenic in immunocompromised people and it is strongly recommended that vaccination occur according to national guidelines. When delivered to immunocompromised populations, HPV vaccines should be given as a 3-dose regimen.
December 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/29123514/assessment-of-the-combined-effect-of-epstein-barr-virus-and-plasmodium-falciparum-infections-on-endemic-burkitt-lymphoma-using-a-multiplex-serological-approach
#13
Ruth Aguilar, Delphine Casabonne, Cristina O'Callaghan-Gordo, Marta Vidal, Joseph J Campo, Nora Mutalima, Evelina Angov, Sheetij Dutta, Deepak Gaur, Chetan E Chitnis, Virander Chauhan, Angelika Michel, Silvia de Sanjosé, Tim Waterboer, Manolis Kogevinas, Rob Newton, Carlota Dobaño
Epstein-Barr virus (EBV) is a necessary cause of endemic Burkitt lymphoma (eBL), while the role of Plasmodium falciparum in eBL remains uncertain. This study aimed to generate new hypotheses on the interplay between both infections in the development of eBL by investigating the IgG and IgM profiles against several EBV and P. falciparum antigens. Serum samples collected in a childhood study in Malawi (2005-2006) from 442 HIV-seronegative children (271 eBL cases and 171 controls) between 1.4 and 15 years old were tested by quantitative suspension array technology against a newly developed multiplex panel combining 4 EBV antigens [Z Epstein-Barr replication activator protein (ZEBRA), early antigen-diffuse component (EA-D), EBV nuclear antigen 1, and viral capsid antigen p18 subunit (VCA-p18)] and 15 P...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29107561/association-of-antiretroviral-therapy-with-high-risk-human-papillomavirus-cervical-intraepithelial-neoplasia-and-invasive-cervical-cancer-in-women-living-with-hiv-a-systematic-review-and-meta-analysis
#14
Helen Kelly, Helen A Weiss, Yolanda Benavente, Silvia de Sanjose, Philippe Mayaud
BACKGROUND: The interactions between antiretroviral therapy (ART) and high-risk human papillomavirus (HPV) and cervical lesions in women living with HIV are poorly understood. We reviewed the association of ART with these outcomes. METHODS: We did a systematic review and meta-analysis by searching MEDLINE and Embase databases for cross-sectional or cohort studies published in English between Jan 1, 1996, and May 6, 2017, which reported the association of ART with prevalence of high-risk HPV or prevalence, incidence, progression, or regression of histological or cytological cervical abnormalities, or incidence of invasive cervcal cancer...
January 2018: Lancet HIV
https://www.readbyqxmd.com/read/29094100/primary-prevention-of-cervical-cancer-american-society-of-clinical-oncology-resource-stratified-guideline
#15
Silvina Arrossi, Sarah Temin, Suzanne Garland, Linda O'Neal Eckert, Neerja Bhatla, Xavier Castellsagué, Sharifa Ezat Alkaff, Tamika Felder, Doudja Hammouda, Ryo Konno, Gilberto Lopes, Emmanuel Mugisha, Rául Murillo, Isabel C Scarinci, Margaret Stanley, Vivien Tsu, Cosette M Wheeler, Isaac Folorunso Adewole, Silvia de Sanjosé
Purpose: To provide resource-stratified (four tiers), evidence-based recommendations on the primary prevention of cervical cancer globally. Methods: The American Society of Clinical Oncology convened a multidisciplinary, multinational panel of oncology, obstetrics/gynecology, public health, cancer control, epidemiology/biostatistics, health economics, behavioral/implementation science, and patient advocacy experts. The Expert Panel reviewed existing guidelines and conducted a modified ADAPTE process and a formal consensus-based process with additional experts (consensus ratings group) for one round of formal ratings...
October 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29074184/hpv-distribution-in-cervical-cancer-in-portugal-a-retrospective-study-from-1928-to-2005
#16
Ana Félix, Laia Alemany, Sara Tous, Silvia de Sanjosé, F Xavier Bosch
OBJECTIVES: To determine human papillomavirus (HPV) types in invasive cervical cancer in Portugal. METHODS: Cases diagnosed at the Instituto Português de Oncologia de Lisboa de Francisco Gentil from the year 1928 to 2005 were selected for HPV DNA detection and genotyping using SPF10/DEIA/LiPA25 system. RESULTS: Of the 1214 samples that were considered appropriate for HPV detection, 714 (58.8%; 95% CI: 56.0-61.6%) were positive for HPV DNA...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/29036167/development-and-validation-of-a-protocol-for-optimizing-the-use-of-paraffin-blocks-in-molecular-epidemiological-studies-the-example-from-the-hpv-ahead-study
#17
MULTICENTER STUDY
Marisa Mena, Belen Lloveras, Sara Tous, Johannes Bogers, Fausto Maffini, Nitin Gangane, Rekha Vijay Kumar, Thara Somanathan, Eric Lucas, Devasena Anantharaman, Tarik Gheit, Xavier Castellsagué, Michael Pawlita, Silvia de Sanjosé, Laia Alemany, Massimo Tommasino
Worldwide use of formalin-fixed paraffin-embedded blocks (FFPE) is extensive in diagnosis and research. Yet, there is a lack of optimized/standardized protocols to process the blocks and verify the quality and presence of the targeted tissue. In the context of an international study on head and neck cancer (HNC)-HPV-AHEAD, a standardized protocol for optimizing the use of FFPEs in molecular epidemiology was developed and validated. First, a protocol for sectioning the FFPE was developed to prevent cross-contamination and distributed between participating centers...
2017: PloS One
https://www.readbyqxmd.com/read/28964706/the-natural-history-of-human-papillomavirus-infection
#18
REVIEW
Silvia de Sanjosé, Maria Brotons, Miguel Angel Pavón
Human papillomavirus (HPV) is a small double-stranded DNA virus that commonly infects humans. The oncogenic characteristics of HPV derive from the oncoproteins E6 and E7 that act inhibiting p53 and pRB tumor suppressors. About 5% of all cancers worldwide are attributable mainly to those known as high-risk, including HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59. Infection with HPV is common after sexual initiation, but the majority of HPV infections do not cause symptoms or disease and are cleared within 12-24 months post-infection...
February 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28888185/helicobacter-pylori-serological-biomarkers-of-gastric-cancer-risk-in-the-mcc-spain-case-control-study
#19
Nerea Fernández de Larrea-Baz, Beatriz Pérez-Gómez, Angelika Michel, Beatriz Romero, Virginia Lope, Michael Pawlita, Tania Fernández-Villa, Victor Moreno, Vicente Martín, Martina Willhauck-Fleckenstein, Gonzalo López-Abente, Jesús Castilla, Guillermo Fernández-Tardón, Trinidad Dierssen-Sotos, Miguel Santibáñez, Rosana Peiró, José Juan Jiménez-Moleón, Carmen Navarro, Gemma Castaño-Vinyals, Manolis Kogevinas, Marina Pollán, Silvia de Sanjosé, Rosa Del Campo, Tim Waterboer, Nuria Aragonés
BACKGROUND: Helicobacter pylori infection is one of the main risk factors for non-cardia gastric cancer. However, only a minority of infected persons develop the disease. This study aims at identifying H. pylori related serological biomarkers of risk for gastric cancer. METHODS: Incident gastric cancer cases and population controls (age, sex and region frequency-matched) from the MCC-Spain multicase-control Study were included. Seroreactivities against 16H. pylori proteins were determined using multiplex serology...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28884278/hpv-prevalence-in-vulvar-cancer-in-austria
#20
Sophie Pils, Lisa Gensthaler, Laia Alemany, Reinhard Horvat, Silvia de Sanjosé, Elmar A Joura
BACKGROUND: Even if vulvar cancer is not common, over one hundred women are affected in Austria per year. There is strong evidence that basaloid and warty variants are associated with types of human papillomavirus (HPV). METHODS: The aim of this study is to analyze the types of HPV in vulvar cancer in Austria. This cross-sectional period-prevalence international collaborative study on archival specimens was performed in cooperation with the Institut Catalan di Oncologia in Barcelona, Spain...
November 2017: Wiener Klinische Wochenschrift
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