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Emmanouil Sinakos, Dimitrios Kountouras, John Koskinas, Kalliopi Zachou, Stylianos Karatapanis, Christos Triantos, Themistoklis Vassiliadis, Ioannis Goulis, Alexandra Kourakli, Efthymia Vlachaki, Barbara Toli, Maria Tampaki, Pinelopi Arvaniti, Georgios Tsiaoussis, Aristea Bellou, Antonis Kattamis, Konstantinos Maragkos, Foteini Petropoulou, George N Dalekos, Evangelos Akriviadis, George V Papatheodoridis
Interferon-based regimens for chronic hepatitis C (CHC) were often deferred in patients with β-thalasaemia major (β-TM) due to poor efficacy and tolerance. Current guidelines recommend direct-acting antivirals (DAAs) for these patients. The aim of this study was to assess the safety and efficacy of DAAs in patients with β-TM and advanced liver disease due to CHC. Patients were recruited from eight liver units in Greece. The stage of liver disease was assessed using transient elastography and/or liver histology...
July 2017: British Journal of Haematology
Saqib Hussain Ansari, Nida Baig, Tahir Sultan Shamsi, Saif-ur-Rehman, Zeeshan Hussain Ansari, Zubaida Behar, Kousar Perveen, Sajida Erum, Zoaib Raza Bukhari, Muhammad Tahir Khan, Mohammad Akbar
OBJECTIVE: To screen immediate family members of thalassaemia patients for carrier identification and counselling. METHODS: The cross-sectional study was conducted at an urban thalassaemia treatment and prevention centre in Karachi, Pakistan, from January to December 2008, and involved 188 siblings of 100 thalassaemia patients. Complete blood count, including haemogram, was performed in the siblings. Samples with MCV < 75fl and MCH < 25% were subjected to haemoglobin-electrophoresis...
December 2012: JPMA. the Journal of the Pakistan Medical Association
Amina Adil, Zain A Sobani, Abdul Jabbar, Salman N Adil, Safia Awan
OBJECTIVE: To determine the major endocrine complications present in patients of Thalassemia major presenting to a tertiary care center in Karachi, Pakistan. METHODS: Records of all thallasemia major patients at a Haematology Department in a tertiary care hospital of Karachi were retrospectively reviewed from May to August 2009 with specific focus on endocrine data and investigations. The patients' data was recorded in a questionnaire and analyzed using SPSS v.17, frequencies and percentages along with corresponding 95% confidence interval were computed...
March 2012: JPMA. the Journal of the Pakistan Medical Association
Li-qin Yao, Tuan-biao Zou, Fa-bin Yang, Li-sha Hu, Qian Chen, Li-mei Fan, Zhong-ming Zhao, Jin-tao Liu, Xing-tian Wang
OBJECTIVE: To investigate the carrier rate of thalasaemia among the children of 10 minority ethnic groups in 3 border states (Xishuangbanna, Dehong and Nujiang) of Yunnan Province. METHODS: A total of 6562 samples of children under 10 years old were analyzed by blood cell automatic analysis and hemoglobin electrophoresis. RESULTS: The overall carrier frequency of thalasaemia was highest (46.2%) in Dehong, and lowest (30.6%) in Nujiang. The carrier frequency of beta-thalasaemia was the highest (40...
October 2011: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Rukhsana Ayub, Nabia Tariq, Malik Muhammad Adil, Mobeen Iqbal, Tara Jaferry, Shan Rasul Rais
OBJECTIVE: To estimate the haemoglobin levels in pregnant women and to determine the socio-demographic factors associated with anaemia in pregnancy. PATIENTS AND METHODS: In this cross-sectional survey, a total of 200 patients visiting prenatal clinic of Shifa International Hospital/Shifa Foundation Community Health Centres, Islamabad over the period of six months, both booked and non-booked were included. A detailed questionnaire was filled and complete blood count, peripheral smear and absolute values were performed in all cases...
February 2009: JPMA. the Journal of the Pakistan Medical Association
No abstract text is available yet for this article.
January 1962: British Journal of Haematology
M Angastiniotis
Chronic hereditary conditions are expected to have a strong influence on the psychosocial development of the adolescent. Thalassaemia major is the commonest of these disorders in Mediterranean countries. In the past it was rarely seen in adolescence because the majority of patients died in childhood. The availability of treatment has allowed survival but the optimum treatment is difficult, especially chelation which consists of daily subcutaneous infusions of 10 hours duration. The adolescent patient must achieve social independence while he/she has a dependency on family, doctors and nurses and a need to strictly adhere to a difficult regime...
December 2002: Minerva Pediatrica
T Meloni, C Colombo, A Ogana, M C Mannazzu, G F Meloni
BACKGROUND: It has recently been suggested that primary lactase deficiency might have been selected for by malaria, as has been previously shown to occur for thalasaemia and glucose 6-phosphate dehydrogenase (G6PD) deficiency. AIMS: To test this hypothesis, the prevalence of primary lactase deficiency in G6PD deficient subjects and in controls from the area of Sassari (Northern Sardinia) was determined, which in the past was characterised by an intermediate malarial endemicity...
August 1996: Gut
G M Perry, B B Anderson, N Dodd
Red-cell conversion rate of pyridoxine to pyridoxal phosphate, and globin synthesis were measured before and after oral riboflavin in a patient with heterozygous beta-thalasaemia in 3 separate trials. In this patient a very slow B6 conversion rate increased to normal on each occasion after riboflavin, and there was a marked increase in synthesis of alpha and beta globin chains but no change in beta/alpha ratio. This was confirmed in a similar patient after a single trial of oral riboflavin. In 5 control subjects after a single trial of riboflavin the red-cell pyridoxine conversion rate increased whether the initial rate was fast or slow, and there was a considerable increase in globin synthesis in 3 of these...
April 1980: Biomedicine / [publiée Pour L'A.A.I.C.I.G.]
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