Samuel J Gavzy, Allison Kensiski, Vikas Saxena, Ram Lakhan, Lauren Hittle, Long Wu, Jegan Iyyathurai, Hima Dhakal, Zachariah L Lee, Lushen Li, Young S Lee, Tianshu Zhang, Hnin Wai Lwin, Marina W Shirkey, Christina M Paluskievicz, Wenji Piao, Emmanuel F Mongodin, Bing Ma, Jonathan S Bromberg
BACKGROUND: Despite ongoing improvements to regimens preventing allograft rejection, most cardiac and other organ grafts eventually succumb to chronic vasculopathy, interstitial fibrosis, or endothelial changes, and eventually graft failure. The events leading to chronic rejection are still poorly understood and the gut microbiota is a known driving force in immune dysfunction. We previously showed that gut microbiota dysbiosis profoundly influences the outcome of vascularized cardiac allografts and subsequently identified biomarker species associated with these differential graft outcomes...
April 8, 2024: Transplantation