keyword
MENU ▼
Read by QxMD icon Read
search

factor deficiency

keyword
https://www.readbyqxmd.com/read/28239777/-limbal-epithelial-stem-cell-transplantation-current-state-and-perspectives
#1
D Meller, H Thomasen
Homeostasis of the corneal surface is maintained by epithelial stem cells localized in the limbus. Multiple intrinsic factors or external injuries can destroy the delicate microenvironment of limbal epithelial stem cells causing a state which is termed limbal stem cell deficiency (LSCD). In such cases, re-epithelialization of the cornea is drastically impeded and conjunctival epithelium starts to extend beyond the limbus and to invade the corneal surface. In partial LSCD, a superficial keratectomy combined with an amniotic membrane is advised and helpful to restore an intact, healthy ocular surface...
February 26, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28239656/autoreactive-helper-t-cells-alleviate-the-need-for-intrinsic-tlr-signaling-in-autoreactive-b-cell-activation
#2
Josephine R Giles, Adriana Turqueti Neves, Ann Marshak-Rothstein, Mark J Shlomchik
T cells play a significant role in the pathogenesis of systemic autoimmune diseases, including systemic lupus erythematosus; however, there is relatively little information on the nature and specificity of autoreactive T cells. Identifying such cells has been technically difficult because they are likely to be rare and low affinity. Here, we report a method for identifying autoreactive T cell clones that recognize proteins contained in autoantibody immune complexes, providing direct evidence that functional autoreactive helper T cells exist in the periphery of normal mice...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239604/predictors-of-antenatal-care-skilled-birth-attendance-and-postnatal-care-utilization-among-the-remote-and-poorest-rural-communities-of-zambia-a-multilevel-analysis
#3
Choolwe Jacobs, Mosa Moshabela, Sitali Maswenyeho, Nildah Lambo, Charles Michelo
OBJECTIVE: Optimal utilization of maternal health-care services is associated with reduction of mortality and morbidity for both mothers and their neonates. However, deficiencies and disparity in the use of key maternal health services within most developing countries still persist. We examined patterns and predictors associated with the utilization of specific indicators for maternal health services among mothers living in the poorest and remote district populations of Zambia. METHODS: A cross-sectional baseline household survey was conducted in May 2012...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28239320/status-of-serum-vitamin-b12-and-folate-in-patients-with-inflammatory-bowel-disease-in-china
#4
Shaozhong Huang, Jiayi Ma, Mingming Zhu, Zhihua Ran
BACKGROUND/AIMS: Inflammatory bowel disease (IBD) primarily involves the intestinal tract and can affect vitamin absorption. This study was designed to assess the prevalence of vitamin B12 and folate deficiencies in patients with IBD, and to identify the risk factors associated with abnormal serum vitamin B12 and folate levels. METHODS: We evaluated the medical records of 195 patients with Crohn's disease (CD) and 62 patients with ulcerative colitis (UC), and selected 118 healthy subjects for the control group...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28238930/the-acute-exposure-of-tetrachloro-p-benzoquinone-a-k-a-chloranil-triggers-inflammation-and-neurological-dysfunction-via-toll-like-receptor-4-signaling-the-protective-role-of-melatonin-preconditioning
#5
Juanli Fu, Xiaomin Xia, Zixuan Liu, Yawen Wang, Yuxin Wang, Qiong Shi, Xiufang Song, Erqun Song, Yang Song
This study is aimed to investigate the inflammation and neurological dysfunction induced by tetrachloro-p-benzoquinone (TCBQ) through Toll-like receptor 4 (TLR4) signaling. We also investigated the protective role of melatonin as an antioxidant and anti-inflammatory agent. In vitro model was established by rat pheochromocytoma PC12 cells, meanwhile, TLR4 wild-type (C57BL/6) and knockout mice (C57BL/10ScNJ TLR4(-/-)) were used as in vivo model. In vitro study showed TCBQ exposure enhanced the expression of TLR4, myeloid differentiation factor 88 (MyD88) at both transcriptional and post-transcriptional levels...
February 23, 2017: Toxicology
https://www.readbyqxmd.com/read/28238855/mkp-1-negatively-regulates-lps-mediated-il-1%C3%AE-production-through-p38-activation-and-hif-1%C3%AE-expression
#6
Harvinder Talwar, Christian Bauerfeld, Mohamad Bouhamdan, Pershang Farshi, Yusen Liu, Lobelia Samavati
Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that plays a major role in inflammatory diseases as well as cancer. The inflammatory response after Toll-like receptor (TLR) 4 activation is tightly regulated through phosphorylation of MAP kinases, including p38 and JNK pathways. The activation of MAP kinases is negatively regulated by MAPK phosphatases (MKPs). MKP-1 preferentially dephosphorylates p38 and JNK. IL-1β is regulated through the activation of MAPK, including p38 as well as several transcription factors...
February 23, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28238747/role-of-c-ebp-homologous-protein-chop-and-endoplasmic-reticulum-in-asthma-exacerbation-by-regulating-the-il-4-stat6-tfec-il-4r%C3%AE-positive-feedback-loop-in-m2-macrophages
#7
Yi Wang, Jianghui Zhu, Lei Zhang, Zhijun Zhang, Long He, Yong Mou, Yanhan Deng, Yong Cao, Ping Yang, Yunchao Su, Jianping Zhao, Shu Zhang, Qilin Yu, Jifa Hu, Zhishui Chen, Qin Ning, Xudong Xiang, Yongjian Xu, Cong-Yi Wang, Weining Xiong
BACKGROUND: C/EBP homologous protein (CHOP), a marker of endoplasmic reticulum (ER) stress, exhibits aberrant expression patterns during the development of asthma. However, its exact role in asthma pathogenesis is not fully understood. OBJECTIVES: We aimed to determine the function and mechanism of CHOP in the pathogenesis of allergic asthma in patients and animals. METHODS: Studies were conducted in asthmatic patients and CHOP(-/-) mice to dissect the role of CHOP and ER stress in asthma pathogenesis...
February 23, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28238053/a-possible-genetic-basis-for-vulnerability-in-euphydryas-maturna-lepidoptera-nymphalidae
#8
Katalin Pecsenye, Andrea Tóth, Judit Bereczki, Zoltán Varga
Nearly all of the known populations of Scarce Fritillary, Euphydryas maturna (Linnaeus, 1758), are declining in Western and Central Europe. In order to identify the possible reasons for its vulnerability we surveyed the population genetics of this butterfly species using multi-locus genotype data. Females of our target species lay lots of eggs in one or two batches only and pre-hibernation caterpillars live and feed gregariously in a nest. As a consequence, a random unfavourable event can eliminate most offspring of a particular female resulting in a strong genetic drift effect combined with inbreeding...
February 25, 2017: Genetica
https://www.readbyqxmd.com/read/28237848/il-17-axis-accelerates-the-inflammatory-progression-of-obese-in-mice-via-tbk1-and-ikbke-pathway
#9
Seung Hoon Lee, JooYeon Jhun, Jae-Kyung Byun, Eun-Kyung Kim, KyoungAh Jung, Ji Eun Lee, Jong Young Choi, Sung-Hwan Park, Mi-La Cho
Obesity mediates immune inflammatory response and induces IL-17 expression. Adipgenesis can be regulated by IL-17 and it causes TBK1 activation. The inhibition of TBK1 and the inhibition of I IKBKE reduces inflammatory response and improves obesity. It is hypothesized that IL-17 deficiency inhibits obesity progression and inflammation. 3T3-L1 preadipocytes were differentiated in vitro and treated with IL-17. RAW264.7 cells and differentiated 3T3-L1 were pretreated with TBK1 inhibitor and then stimulated with IL-17...
February 22, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28237703/effect-of-cellular-ubiquitin-levels-on-the-regulation-of-oxidative-stress-response-and-proteasome-function-via-nrf1
#10
Donghee Lee, Kwon-Yul Ryu
The polyubiquitin genes Ubb and Ubc are upregulated under oxidative stress induced by arsenite [As(III)]. However, the role of ubiquitin (Ub) under As(III) exposure is not known in detail. In a previous study, we showed that the reduced viability observed in Ubc(-/-) mouse embryonic fibroblasts under As(III) exposure was not due to dysregulation of the Nrf2-Keap1 pathway, which prompted us to investigate another NFE2 family protein, nuclear factor erythroid 2-related factor 1 (Nrf1). In this study, we found that Ub deficiency due to Ubc knockdown in N2a cells reduced cell viability and proteasome activity under As(III) exposure...
February 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28237591/methionine-leucine-isoleucine-or-threonine-effects-on-mammary-cell-signaling-and-pup-growth-in-lactating-mice
#11
G M Liu, M D Hanigan, X Y Lin, K Zhao, F G Jiang, R R White, Y Wang, Z Y Hu, Z H Wang
Two studies were undertaken to assess the effects of individual essential AA supplementation of a protein-deficient diet on lactational performance in mice using litter growth rates as a response variable. The first study was designed to establish a dietary protein response curve, and the second to determine the effects of Leu, Ile, Met, and Thr supplementation of a protein-deficient diet on lactational performance. In both studies, dams were fed test diets from parturition through d 17 of lactation, when the studies ended...
February 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28237515/adiporon-an-adiponectin-receptor-agonist-attenuates-pdgf-induced-vsmc-proliferation-through-inhibition-of-mtor-signaling-independent-of-ampk-implications-toward-suppression-of-neointimal-hyperplasia
#12
Arwa Fairaq, Noha M Shawky, Islam Osman, Prahalathan Pichavaram, Lakshman Segar
Hypoadiponectinemia is associated with an increased risk of coronary artery disease. Although adiponectin replenishment mitigates neointimal hyperplasia and atherosclerosis in mouse models, adiponectin therapy has been hampered in a clinical setting due its large molecular size. Recent studies demonstrate that AdipoRon (a small-molecule adiponectin receptor agonist) improves glycemic control in type 2 diabetic mice and attenuates postischemic cardiac injury in adiponectin-deficient mice, in part, through activation of AMP-activated protein kinase (AMPK)...
February 22, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28237306/influence-of-phosphate-on-phytotoxicity-of-ceria-nanoparticles-in-an-agar-medium
#13
Guohua Wang, Yuhui Ma, Peng Zhang, Xiao He, Zhaohui Zhang, Meihua Qu, Yayun Ding, Junzhe Zhang, Changjian Xie, Wenhe Luo, Jing Zhang, Shengqi Chu, Zhifang Chai, Zhiyong Zhang
Fate and toxicity of manufactured nanoparticles (NPs) in the living organisms and the environment are highly related to their transformation. In the present study, the effect of phosphate on the phytotoxicity and transformation of CeO2 NPs was investigated in an agar medium using head lettuce plants that are sensitive to Ce(3+) ions. Plants were treated by CeO2 NPs with or without phosphate for 10 days. Results suggest that the treatments of P deficiency (P(-)) and CeO2 NPs (P(+)&Ce) could separately induce significant inhibition on the growth of lettuce seedlings and cause oxidative stress, but the inhibition was the most serious when the two conditions were combined (P(-)&Ce)...
February 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28236968/regulation-of-embryonic-and-postnatal-development-by-the-csf-1-receptor
#14
Violeta Chitu, E Richard Stanley
Macrophages are found in all tissues and regulate tissue morphogenesis during development through trophic and scavenger functions. The colony stimulating factor-1 (CSF-1) receptor (CSF-1R) is the major regulator of tissue macrophage development and maintenance. In combination with receptor activator of nuclear factor κB (RANK), the CSF-1R also regulates the differentiation of the bone-resorbing osteoclast and controls bone remodeling during embryonic and early postnatal development. CSF-1R-regulated macrophages play trophic and remodeling roles in development...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28236843/multiple-sclerosis-and-air-pollution-exposure-mechanisms-toward-brain-autoimmunity
#15
Sayed Esmaeil Mousavi, Pouria Heydarpour, Jacques Reis, Masoud Amiri, Mohammad Ali Sahraian
The association between neurodegenerative diseases and environmental exposures, in particular air pollution, has been noticed in the last two decades, but the importance of this environmental factor in multiple sclerosis (MS) pathogenesis has not been considered extensively. However, recent evidence suggests that major mechanisms involved in MS pathogenesis, such as inflammatory factors expression, free radicals overproduction, the blood brain barrier (BBB) breakdown, neuroinflammation, vitamin D deficiency and mitochondrial dysfunction could also occur due to exposure to air pollutants...
March 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28236525/role-of-serum-adiponectin-and-vitamin-d-in-prediabetes-and-diabetes-mellitus
#16
Anindita Banerjee, Vineet Kumar Khemka, Debashree Roy, Jit Poddar, Tapan Kumar Sinha Roy, Srikanth Arliganur Karnam
OBJECTIVES: The roles of deficient or deranged insulin, adiponectin and 25 hydroxy vitamin D (25[OH]D) levels regulating food intake, energy metabolism, glucose and lipid metabolism and body weight have been reported in the pathogenesis of prediabetes and type 2 diabetes mellitus. However, their congruity in the etiology of diabetes mellitus is unknown. Thus, the aim of the study was to investigate the roles of these parameters together and to establish their interrelationship in patients with prediabetes and diabetes...
February 21, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28236433/regulators-of-mitochondrial-quality-control-differ-in-subcutaneous-fat-of-metabolically-healthy-and-unhealthy-obese-monkeys
#17
Kylie Kavanagh, Ashley T Davis, Diane E Peters, Andre C LeGrand, Manish S Bharadwaj, Anthony J A Molina
OBJECTIVE: Obesity exists with and without accompanying cardiometabolic disease, termed metabolically unhealthy obesity (MUO) and healthy obesity (MHO), respectively. Underlying differences in the ability of subcutaneous (SQ) fat to respond to nutrient excess are emerging as a key pathway. This study aimed to document the first spontaneous animal model of MHO and MUO and differences in SQ adipose tissue. METHODS: Vervet monkeys (Chlorocebus aethiops; N = 171) were screened for metabolic syndrome...
February 25, 2017: Obesity
https://www.readbyqxmd.com/read/28231689/are-children-with-asthma-in-south-korea-also-associated-with-vitamin-d-deficiency
#18
Yu-Ri Kim, Sung-Chul Seo, Young Yoo, Ji Tae Choung
Recently, epidemiologic studies have shown that the lack of vitamin D levels may be associated with high asthma prevalence, but its effect is still controversial, depending on season, area, and food consumption. We aimed to examine the association of serum vitamin D levels with the prevalence of pediatric asthma in Korea. A total of 80 children (50 asthmatic children and 30 healthy controls) aged 6-14 years were participated in this study. Serum 25-hydroxy vitamin D (vitamin D) levels were measured and compared between the two groups...
February 14, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/28231146/calcium-in-gluten-free-life-health-related-and-nutritional-implications
#19
REVIEW
Urszula Krupa-Kozak, Natalia Drabińska
Calcium deficiency and metabolic bone diseases are a frequent co-morbidity of coeliac disease (CD). Gluten-free diet (GFD) is the only effective treatment of CD. However, CD patients on the strict GFD consume less than the recommended amounts of calcium. In this review, the main etiological factors responsible for calcium deficiency in CD were presented. Additionally, the research on the application of calcium supplements in the gluten-free breadmaking was reviewed, and its effect on the technological and sensory properties of baked products was indicated...
July 15, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231019/pro-inflammatory-cytokines-impair-vitamin-d-induced-host-defense-in-cultured-airway-epithelial-cells
#20
Jasmijn A Schrumpf, Gimano D Amatngalim, Joris B Veldkamp, Renate M Verhoosel, Dennis K Ninaber, Soledad R Ordonez, Anne M van der Does, Henk P Haagsman, Pieter S Hiemstra
Vitamin D is a regulator of host defense against infections and induces expression of the antimicrobial peptide hCAP18/LL-37. Vitamin D deficiency is associated with chronic inflammatory lung diseases and respiratory infections. However, it is incompletely understood if and how (chronic) airway inflammation affects vitamin D metabolism and action. We hypothesized that long-term exposure of primary bronchial epithelial cells (PBEC) to pro-inflammatory cytokines alters their vitamin D metabolism, antibacterial activity and expression of hCAP18/LL-37...
February 23, 2017: American Journal of Respiratory Cell and Molecular Biology
keyword
keyword
77729
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"