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https://www.readbyqxmd.com/read/28206996/the-quest-for-sustained-multiple-morbidity-reduction-in-very-low-birth-weight-infants-the-antifragility-project
#1
J W Kaempf, N M Schmidt, S Rogers, C Novack, M Friant, L Wang, N Tipping
OBJECTIVE: Can a comprehensive, explicitly directive evidence-based guideline for all therapies that might affect the major morbidities of very low-birth-weight (VLBW) infants help a neonatal intensive care unit (NICU) further improve generally favorable morbidity rates? Can Antifragility principles of provider adaptive growth from stressors, enhanced infant risk assessment and adherence to effective therapies minimize unproven treatments and reduce all morbidities? STUDY DESIGN: Prospectively planned observational trial in VLBW infants: control group born October 2011 to September 2013 and study group October 2013 to September 2015...
February 16, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28202410/atypical-antipsychotic-clozapine-reversed-deficit-on-prepulse-inhibition-of-the-acoustic-startle-reflex-produced-by-microinjection-of-doi-into-the-inferior-colliculus-in-rats
#2
Rodolpho Pereira de Oliveira, Karen Yuriko Nagaishi, Regina Cláudia Barbosa Silva
Dysfunctions of the serotonergic system have been suggested to be important in the neurobiology of schizophrenia. Patients with schizophrenia exhibit deficits in an operational measure of sensorimotor gating: prepulse inhibition (PPI) of startle. PPI is the normal reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus (pulse). The hallucinogen 2,5-dimethoxy-4-iodoamphetamine (DOI), a 5-hydroxytryptamine(HT)2 receptor agonist disrupted PPI in rats...
February 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28197400/effect-of-gingival-fibroblasts-and-ultrasound-on-dogs-root-resorption-during-orthodontic-treatment
#3
Jacqueline Crossman, Ali H Hassan, Ali Saleem, Nayef Felemban, Saleh Aldaghreer, Elham Fawzi, Mamdouh Farid, Khaled Abdel-Ghaffar, Ausama Gargoum, Tarek El-Bialy
OBJECTIVES: To investigate the effect of using osteogenic induced gingival fibroblasts (OIGFs) and low intensity pulsed ultrasound (LIPUS) on root resorption lacunae volume and cementum thickness in beagle dogs that received orthodontic tooth movement. MATERIALS AND METHODS: Seven beagle dogs were used, from which gingival cells (GCs) were obtained and were induced osteogenically to produce OIGFs. Each third and fourth premolar was randomly assigned to one of the five groups, namely, LIPUS, OIGFs, bone morphogenetic protein-2 (BMP-2), OIGFs + LIPUS, and control...
January 2017: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/28195362/low-intensity-ultrasound-enhances-histone-acetylation-and-inhibition-of-interleukin-6-messenger-rna-expression-by-the-histone-deacetylase-inhibitor-sodium-butyrate-in-fibroblasts
#4
Noriaki Maeshige, Yuka Koga, Masayuki Tanaka, Michiko Aoyama-Ishikawa, Makoto Miyoshi, Makoto Usami, Hidemi Fujino
OBJECTIVES: Sodium butyrate, an inhibitor of histone deacetylase, has several therapeutic actions, including anti-inflammation. These actions depend on the concentration of sodium butyrate. In addition, lower concentrations have shown no effect on inflammation. Sonoporation by ultrasound can modify the permeability of the cell plasma membrane. Thus, the effects of sodium butyrate may be enhanced by the ultrasonic acoustics. Therefore, the facilitative effects of low-intensity ultrasound on histone acetylation and interleukin 6 (IL-6) regulation by sodium butyrate were investigated in this study...
February 3, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28188834/amelioration-of-cerebellar-dysfunction-in-rats-following-postnatal-ethanol-exposure-using-low-intensity-pulsed-ultrasound
#5
Hiva Mohammadi Bolbanabad, Enayat Anvari, Mohammad Jafar Rezai, Ardashir Moayeri, Mohammad Reza Kaffashian
BACKGROUND: The neonatal development stage of the cerebellum in rats is equivalent to a human foetus in the third trimester of pregnancy. In this stage, cell proliferation, migration, differentiation, and synaptogenesis occur. Clinical and experimental findings have shown that ethanol exposure during brain development causes a variety of disruptions to the brain, including neurogenesis depression, delayed neuronal migration, changes in neurotransmitter synthesis, and neuronal depletion...
February 7, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28174268/failure-to-reproduce-period-dependent-song-cycles-in-drosophila-is-due-to-poor-automated-pulse-detection-and-low-intensity-courtship
#6
Charalambos P Kyriacou, Edward W Green, Arianna Piffer, Harold B Dowse
Stern has criticized a body of work from several groups that have independently studied the so-called "Kyriacou and Hall" courtship song rhythms of male Drosophila melanogaster, claiming that these ultradian ∼60-s cycles in the interpulse interval (IPI) are statistical artifacts that are not modulated by mutations at the period (per) locus [Stern DL (2014) BMC Biol 12:38]. We have scrutinized Stern's raw data and observe that his automated song pulse-detection method identifies only ∼50% of the IPIs found by manual (visual and acoustic) monitoring...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28173722/effect-of-a-low-frequency-pulsed-electromagnetic-field-on-expression-and-secretion-of-il-1%C3%AE-and-tnf-%C3%AE-in-nucleus-pulposus-cells
#7
Jun Zou, Yufeng Chen, Jiale Qian, Huilin Yang
Objective To investigate changes in nucleus pulposus cell expression and secretion of interleukin (IL)-1β and tumour necrosis factor (TNF)-α following stimulation with a low-frequency (LF) pulsed electromagnetic field (PEMF). Methods Primary rat nucleus pulposus cells were isolated and cultured in vitro, followed by stimulation with LF-PEMFs at a frequency of 2 Hz and different intensities, ranging from 0.5-3.0 A/m. Cells were observed for morphological changes, and proliferation rates were measured by cell viability counts...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28166492/coded-excitation-for-low-snr-pulse-echo-systems
#8
Julio Isla, Frederic Cegla
Pulse compression has been used for decades in radar, sonar, medical and industrial ultrasound. It consists in transmitting a modulated and/or coded excitation, which is then cross-correlated with the received signal such that received echoes are time-compressed, thereby increasing their intensity and hence the system resolution and signal-to-noise ratio (SNR). A central problem in pulse-echo systems is that, while longer coded excitations yield higher SNRs, the length of the coded excitation or sequence is limited by the distance between the closest reflector and the transmitter/receiver...
January 30, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28158164/rapid-and-delayed-effects-of-pulsed-radiofrequency-on-neuropathic-pain-electrophysiological-molecular-and-behavioral-evidence-supporting-long-term-depression
#9
Ren-Yu Huang, Chia-Chi Liao, Shih-Ying Tsai, Chen-Tung Yen, Chii-Wann Lin, Tsung-Chi Chen, Wei-Tso Lin, Chi-Heng Chang, Yeong-Ray Wen
BACKGROUND: Pulsed radiofrequency (PRF) has been widely employed for ameliorating clinical neuropathic pain. How PRF alters electrophysiological transmission and modulates biomolecular functions in neural tissues has yet to be clarified. We previously demonstrated that an early application of low-voltage bipolar PRF adjacent to the dorsal root ganglion (DRG) reduced acute neuropathic pain in animals. By contrast, the present study investigated how PRF alters postsynaptic sensitization to produce early and delayed effects on neuropathic pain...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28158105/time-resolved-thermal-lens-spectroscopy-with-a-single-pulsed-laser-excitation-beam-an-analytical-model-for-dual-beam-mode-mismatched-experiments
#10
Mohammad Sabaeian, Hamidreza Rezaei, Abdolmohammad Ghalambor-Dezfouli
Pulsed laser beam excitations are more commonly used in thermal lens spectroscopy (TLS) than continuous-wave (CW) ones, because CW excitations limit the measurement to linear absorption processes [J. Opt. A5, 256 (2003)]. In this work, we present a new and full analytical model for a single-pulsed laser excitation dual-beam mode-mismatched TLS for low absorption solid-state and liquid samples. Our model has been based on a new solution of time-dependent heat equation for a finite-radius cylindrical sample exposed to a single-pulsed excitation laser beam...
February 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28157952/intensity-fluctuation-of-a-gain-switched-semiconductor-laser-for-quantum-key-distribution-systems
#11
Kensuke Nakata, Akihisa Tomita, Mikio Fujiwara, Ken-Ichiro Yoshino, Akio Tajima, Atsushi Okamoto, Kazuhisa Ogawa
Security certification of quantum key distribution (QKD) systems under practical conditions is necessary for social deployment. This article focused on the transmitter, and, in particular, investigated the intensity fluctuation of the optical pulses emitted by a gain-switched semiconductor laser used in QKD systems implementing decoy-BB84 protocol. A large intensity fluctuation was observed for low excitation, showing strong negative correlation between the adjacent pulses, which would affect the final key rate...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28153478/perfusion-index-and-pulse-oximetry-screening-for-congenital-heart-defects
#12
Federico Schena, Irene Picciolli, Massimo Agosti, Antonio Alberto Zuppa, Gianvincenzo Zuccotti, Luciana Parola, Giulia Pomero, Giorgio Stival, Markus Markart, Silvia Graziani, Luigi Gagliardi, Cristina Bellan, Simona La Placa, Giuseppe Limoli, Gabriella Calzetti, Andrea Guala, Enza Bonello, Fabio Mosca
OBJECTIVE: To evaluate the efficacy of combined pulse oximetry (POX) and perfusion index (PI) neonatal screening for severe congenital heart defects (sCHD) and assess different impacts of screening in tertiary and nontertiary hospitals. STUDY DESIGN: A multicenter, prospective study in 10 tertiary and 6 nontertiary maternity hospitals. A total of 42 169 asymptomatic newborns from among 50 244 neonates were screened; exclusion criteria were antenatal sCHD diagnosis, postnatal clinically suspected sCHD, and neonatal intensive care unit admission...
January 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28146539/laser-crater-enhanced-raman-spectroscopy
#13
Vasily N Lednev, Pavel A Sdvizhenskii, Mikhail Ya Grishin, Mikhail N Filippov, Alexander N Shchegolikhin, Sergey M Pershin
Raman signal enhancement by multiple scattering inside laser crater cones was observed for the first time, to the best of our knowledge. Laser crater enhanced Raman spectroscopy (LCERS) yielded a 14-fold increase in the Raman spectra bands due to efficient multiple scattering of laser irradiation within the laser crater walls. The same pulsed Nd:YAG laser (532 nm, 10 ns) was used for both laser crater formation and Raman scattering experiments by varying the output pulse energy. First, powerful pulses are used to produce the laser crater; then low-energy pulses are used to perform Raman scattering measurements...
February 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28135747/-flexible-guidance-of-ultra-short-laser-pulses-in-ophthalmic-therapy-systems
#14
J Blum, M Blum, M S Rill, J Haueisen
In the last 20 years, the role of ultrashort pulsed lasers in ophthalmology has become increasingly important. However, it is still impossible to guide ultra-short laser pulses with standard glass fibres. The highly energetic femtosecond pulses would destroy the fibre material, and non-linear dispersion effects would significantly change beam parameters. In contrast, photonic crystal fibres mainly guide the laser pulses in air, so that absorption and dispersive pulse broadening have essentially no effect. This article compares classical beam guidance with mirrors, lenses and prisms with photonic crystal fibres and describes the underlying concepts and the current state of technology...
January 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28134628/when-is-a-fracture-not-fresh-aligning-reimbursement-with-patient-outcome
#15
Robert Zura, Zekun Jack Xu, Gregory J Della Rocca, Samir Mehta, R Grant Steen
OBJECTIVE: The clinical value of low-intensity pulsed ultrasound (LIPUS) for fresh fracture is known. Yet in the absence of a definition of what "fresh" is, payers have adopted study inclusion criteria drawn from randomized clinical trials as de facto definitions of which patients should be treated, with "fresh" defined as <1 week old. Fracture patients may thus be ineligible for LIPUS treatment after week 1, which potentially denies access to patients who could benefit from LIPUS...
February 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28128685/scar-remodeling-with-the-association-of-monopolar-capacitive-radiofrequency-electric-stimulation-and-negative-pressure
#16
Giovanni Nicoletti, Paola Perugini, Sara Bellino, Priscilla Capra, Alberto Malovini, Omar Jaber, Marco Tresoldi, Angela Faga
OBJECTIVE: A study was established to objectively assess the effects of low-intensity electromagnetic and electric stimulation plus negative pressure on mature scars. BACKGROUND: Radiofrequency plus negative pressure therapy demonstrated a favorable reorganization and regeneration of the collagen and elastic fibers and was proposed for the treatment of cellulitis and skin stretch marks. METHODS: Twenty-six mature scars in 20 Caucasian patients (15 females and 5 males) were enrolled in the study...
January 24, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28127791/gene-expression-profiling-analysis-of-the-effects-of-low-intensity-pulsed-ultrasound-on-induced-pluripotent-stem-cells-derived-neural-crest-stem-cells
#17
Bin Xia, Yang Zou, Zhiling Xu, Yonggang Lv
Low-intensity pulsed ultrasound (LIPUS) is a non-invasive technique that has been shown to affect the cell proliferation, migration, differentiation, and promote the regeneration of damaged peripheral nerve. Our previous studies had proved that LIPUS can significantly promote the neural differentiation of induced pluripotent stem cells-derived neural crest stem cells (iPSCs-NCSCs) and enhance the repair of rat transected sciatic nerve. To further explore the underlying mechanisms of LIPUS treatment on iPSCs-NCSCs, this study reported the gene expression profiling analysis of iPSCs-NCSCs before and after LIPUS treatment using RNA-sequencing (RNA-Seq) method...
January 26, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28125779/monolayer-ws2-nanopores-for-dna-translocation-with-light-adjustable-sizes
#18
Gopinath Danda, Paul Masih Das, Yung-Chien Chou, Jerome T Mlack, William M Parkin, Carl H Naylor, Kazunori Fujisawa, Tianyi Zhang, Laura Beth Fulton, Mauricio Terrones, Alan T Charlie Johnson, Marija Drndić
Two-dimensional materials are promising for a range of applications, as well as testbeds for probing the physics of low-dimensional systems. Tungsten disulfide (WS2) monolayers exhibit a direct band gap and strong photoluminescence (PL) in the visible range, opening possibilities for advanced optoelectronic applications. Here, we report the realization of two-dimensional nanometer-size pores in suspended monolayer WS2 membranes, allowing for electrical and optical response in ionic current measurements. A focused electron beam was used to fabricate nanopores in WS2 membranes suspended on silicon-based chips and characterized using PL spectroscopy and aberration-corrected high-resolution scanning transmission electron microscopy...
February 1, 2017: ACS Nano
https://www.readbyqxmd.com/read/28122416/gain-with-no-pain-pain-management-in-dermatological-photodynamic-therapy
#19
REVIEW
B Wang, L Shi, Y F Zhang, Q Zhou, J Zheng, R M Szeimies, X L Wang
Pain during photodynamic therapy (PDT) is the main limiting adverse effect in its use in dermatology. Given its multifactorial nature, we reviewed both intrinsic and extrinsic factors that are involved in PDT pain. We proposed a threshold theory for pain experience in PDT: it positively correlates with fluence rate and dose below certain threshold (rate of ~60 mW/cm(2) , dose of ~50 J/cm(2) ); when threshold is surpassed, pain intensity no longer increases. Additionally, we carefully compared recent updates on pain management strategies and we suggested that cold air analgesia and low-irradiance light source (such as intense pulsed light and day-light PDTs) represent the current best analgesic options...
January 25, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28107035/determination-of-the-zinc-concentration-in-human-fingernails-using-laser-induced-breakdown-spectroscopy
#20
Vlora A Riberdy, Christopher J Frederickson, Steven J Rehse
The absolute concentration of Zn in human fingernail clippings was determined ex vivo using 1064 nm laser-induced breakdown spectroscopy and confirmed by speciated isotope dilution mass spectrometry. A nail testing protocol that sampled across the nail (perpendicular to the direction of growth) was developed and validated by scanning electron microscopy energy-dispersive X-ray spectrometry. Using this protocol, a partial least squares (PLS) regression model predicted the Zn concentration in the fingernails of five people to within an average of 7 ppm...
January 1, 2017: Applied Spectroscopy
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