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Low-intensity pulsed

Xueliang Bao, Yuxuan Zhou, Yunlong Wang, Jianjun Zhang, Xiaoying Lü, Zhigong Wang
It is still challenging to achieve a complex grasp or fine finger control by using surface functional electrical stimulation (FES), which usually requires a precise electrode configuration under laboratory or clinical settings. The goals of this study are as follows: 1) to study the possibility of selectively activating individual fingers; 2) to investigate whether the current activation threshold and selective range of individual fingers are affected by two factors: changes in the electrode position and forearm rotation (pronation, neutral and supination); and 3) to explore a theoretical model for guidance of the electrode placement used for selective activation of individual fingers...
2018: PloS One
Liang Tang, Nan Li, Wenqi Jian, Yiting Kang, Bo Yin, Shuxin Sun, Jianzhong Guo, Lijun Sun, Dean Ta
BACKGROUND: Type 1 diabetes mellitus (T1DM) induces serious skeletal muscle atrophy. Low-intensity pulsed ultrasound (LIPUS) is a common treatment for skeletal muscle injury and is effective in accelerating the rate of muscle growth. However, to the best of our knowledge, whether LIPUS can improve skeletal muscle atrophy in type 1 diabetic rats has not been investigated. METHODS: The rats were randomly divided into four groups: the normal control group (NC); the sham-treated diabetic control group (DC); the diabetic, insulin-treated group (DI) as a positive control; and the diabetic LIPUS therapy group (DL)...
December 22, 2017: Skeletal Muscle
Li Ling, Xiushan Feng, Tianqin Wei, Yan Wang, Yaping Wang, Wenqian Zhang, Lianli He, Ziling Wang, Qianru Zeng, Zhengai Xiong
BACKGROUND: Human amnion-derived mesenchymal stem cells (hAD-MSCs) have the features of mesenchymal stem cells (MSCs). Low-intensity pulsed ultrasound (LIPUS) can promote the expression of various growth factors and anti-inflammatory molecules that are necessary to keep the follicle growing and to reduce granulosa cell (GC) apoptosis in the ovary. This study aims to explore the effects of LIPUS-pretreated hAD-MSC transplantation on chemotherapy-induced primary ovarian insufficiency (POI) in rats...
December 19, 2017: Stem Cell Research & Therapy
Marco Aurélio Vaz, Viviane Bortoluzzi Frasson
OBJECTIVE: To compare the effectiveness of low-frequency pulsed current versus kilohertz-frequency alternating current in terms of evoked-force, discomfort level, current intensity, and muscle fatigability, to discuss the physiological mechanisms of each Neuromuscular Electrical Stimulation type, and to determine if kilohertz-frequency alternating current is better than low-frequency pulsed current for clinical treatment. DATA SOURCES: Manuscripts were obtained from PUBMED, SCOPUS, CENTRAL, CINAHL and SPORTSDISCUS databases using the terms "Russian current" OR "Kilohertz current" OR "Alternating current" OR "Pulsed current" OR "Aussie current" AND torque OR discomfort OR fatigue OR "current intensity", and through citation tracking up to July 2017...
December 13, 2017: Archives of Physical Medicine and Rehabilitation
Thomas Willemsen, Marco Jupé, Mark Gyamfi, Sebastian Schlichting, Detlev Ristau
Dielectric components are essential for laser applications. Chirped mirrors are applied to compress the temporal pulse broadening crucial in the femtosecond regime. However, the design sensitivity and the electric field distribution of chirped mirrors is complex often resulting in low laser induced damage resistances. An approach is presented to increase the damage resistance of pulse compressing mirrors up to 190% in the NIR spectral range. Layers with critical high field intensity of a binary mirror design are substituted by ternary composites and quantized nanolaminates, respectively...
December 11, 2017: Optics Express
Wei Chen, Jintao Fan, Aichen Ge, Huanyu Song, Youjian Song, Bowen Liu, Lu Chai, Chingyue Wang, Minglie Hu
We characterize the relative intensity noise (RIN) and relative timing jitter (RTJ) between the signal and pump pulses of optical parametric amplifiers (OPAs) seeded by three different seed sources. Compared to a white-light continuum (WLC) seeded- and an optical parametric generator (OPG) seeded OPA, the narrowband CW seeded OPA exhibits the lowest root-mean-square (RMS) RIN and RTJ of 0.79% and 0.32 fs, respectively, integrated from 1 kHz to the Nyquist frequency of 1.25 MHz. An improved numerical model based on a forward Maxwell equation (FME) is built to investigate the transfers of the pump and seed's noise to the resulting OPAs' intensity and temporal fluctuation...
December 11, 2017: Optics Express
Mohsen Sheykhlouvand, Erfan Khalili, Mohammadali Gharaat, Hamid Arazi, Mousa Khalafi, Bahman Tarverdizadeh
Brief, intense exercise training employing running and cycling as exercise interventions may induce aerobic and anaerobic adaptations in athletes from wide range of sports. However, this has not been studied extensively for those sports in which the upper-body is predominantly involved. Our purpose was to examine the effects of kayak paddling-based sprint interval training (SIT) on cardiorespiratory fitness and anaerobic performance. 16 professional female canoe polo athletes (age = 27.6 ± 1.9 years; height = 165...
December 11, 2017: Journal of Strength and Conditioning Research
Susan M Murphy, Shahed Omar
BACKGROUND: The primary objective of this study was to assess the clinical usefulness of a point-of-care device which measures hemoglobin noninvasively (SpHb) in a group of critically ill participants with dark skin pigmentation. METHODS: One hundred forty-six adult and pediatric participants from a multidisciplinary intensive care unit had intermittent readings of noninvasive hemoglobin measurements performed at a minimum of 4 hourly intervals. A total of 371 readings were analyzed...
December 11, 2017: Anesthesia and Analgesia
Peng Xia, Xiaoju Wang, Yanping Qu, Qiang Lin, Kai Cheng, Mingxia Gao, Shasha Ren, Tingting Zhang, Xueping Li
BACKGROUND: Low-intensity pulsed ultrasound (LIPUS) is a mechanical stimulus that plays a key role in regulating the differentiation of bone marrow mesenchymal stem cells (BMSCs). However, the way in which it affects the chondrogenic differentiation of BMSCs remains unknown. In this study, we aimed to investigate whether LIPUS is able to influence TGF-β1-induced chondrogenesis of BMSCs through the integrin-mechanistic target of the Rapamycin (mTOR) signaling pathway. METHODS: BMSCs were isolated from rat bone marrow and cultured in either standard or TGF-β1-treated culture medium...
December 13, 2017: Stem Cell Research & Therapy
Charlotte Constans, Philippe Mateo, Mickael Tanter, Jean-Francois Aubry
In the past decade, a handful but growing number of groups have reported worldwide successful low intensity focused ultrasound induced neurostimulation trials on rodents with effects ranging from movement elicitations to reduction of anesthesia time or reduction of the duration of drug induced seizures. The mechanisms underlying ultrasonic neuromodulation are still not fully understood. Given the low intensities used in most of the studies, a mechanical effect is more likely to be responsible for the neuromodulation effect, but a clear description of the thermal and mechanical effects is necessary to optimize clinical applications...
December 13, 2017: Physics in Medicine and Biology
Camilo Andres Rojas Cifuentes, Mariateresa Tedesco, Paolo Massobrio, Attilio Marino, Gianni Ciofani, Sergio Martinoia, Roberto Raiteri
OBJECTIVE: We aim at developing novel non-invasive or minimally invasive methods for neural stimulation to be applied in the study and treatment of brain (dys)functions and neurological disorders. APPROACH: We investigate the electrophysiological response of in vitro neuronal networks when subjected to low intensity pulsed acoustic stimulation mediated by piezoelectric nanoparticles adsorbed on the neuronal membrane. MAIN RESULTS: We show that the presence of piezoelectric barium titanate nanoparticles induces, in a reproducible way, an increase in the network activity when excited by stationary ultrasound waves in the MHz regime...
December 13, 2017: Journal of Neural Engineering
Takahiro Kondo, Naoki Yamada, Ryo Momosaki, Masato Shimizu, Masahiro Abo
Background: The purpose of this study was to evaluate the difference between the therapeutic effect of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) and that of continuous theta burst stimulation (cTBS), when each is combined with intensive occupational therapy (OT), in poststroke patients with upper limb hemiparesis. Materials and Methods: The study subjects were 103 poststroke patients with upper limb hemiparesis, who were divided into two groups: the LF-rTMS group (n = 71) and the cTBS group (three pulse bursts at 50 Hz) (n = 32)...
2017: BioMed Research International
M Kübel, Z Dube, A Yu Naumov, M Spanner, G G Paulus, M F Kling, D M Villeneuve, P B Corkum, A Staudte
Ionization of an atom or molecule by a strong laser field produces suboptical cycle wave packets whose control has given rise to attosecond science. The final states of the wave packets depend on ionization and deflection by the laser field, which are convoluted in conventional experiments. Here, we demonstrate a technique enabling efficient electron deflection, separate from the field driving strong-field ionization. Using a midinfrared deflection field permits one to distinguish electron wave packets generated at different field maxima of an intense few-cycle visible laser pulse...
November 3, 2017: Physical Review Letters
Marta Castrillo, Eva M Luque, Javier Pardo-Medina, M Carmen Limón, Luis M Corrochano, Javier Avalos
Stimulation by light of carotenoid biosynthesis in the mycelia of the fungus Neurospora crassa starts with transient transcriptional induction of the structural genes of the pathway triggered by the White Collar photoreceptor complex. Most studies on this process were carried out under standard growth conditions, but photoinduced carotenoid accumulation is more efficient if the fungus is incubated at low temperatures, from 6 to 12°C. We have investigated the transcriptional photoresponse at 8°C of the genes for proteins that participate in the carotenoid pathway...
December 1, 2017: Research in Microbiology
Tian-Ming Feng, Ming-Cong Yang, Lan-Lan Pan, Chen-Xi Fei, Chao Wang, Xue-Rong Xiang, Jun Sun
PURPOSE: To evaluate the effect of low-intensity pulsed ultrasound(LIPUS) combined with triamcinolone acetonide on oral mucosal ulcer in syrian hamster in several ways, including healing time, contents of superoxide dismutase(SOD)and malondialdehyde (MDA). METHODS: Sixty syrian hamsters were randomly divided into 5 groups, including a baseline group (containing a normal baseline group and a model baseline group, n=6) and 4 experimental groups (LIPUS processing and drug use group, LIPUS group, drug group and a normal control group without any processing, n=12)...
August 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
K Hicke, D Brunner, M C Soriano, I Fischer
We investigate the dynamics of semiconductor lasers subject to time-delayed optical feedback from the perspective of dynamical self-injection locking. Based on the Lang-Kobayashi model, we perform an analysis of the well-known Low Frequency Fluctuations (LFFs) in the frequency-intensity plane. Moreover, we investigate a recently found dynamical regime of fragmented LFFs by means of a locking-range analysis, spectral comparison and precursor pulse identification. We show that LFF dynamics can be explained by dynamical optical injection locking due to the delayed optical feedback...
November 2017: Chaos
Evaldo Moreira da Silva Junior, Raquel Agnelli Mesquita-Ferrari, Cristiane Miranda França, Lucas Andreo, Sandra Kalil Bussadori, Kristianne Porta Santos Fernandes
AIMS: The purpose of this study was toclarify the effect of low intensity pulsed ultrasound (LIPUS) on the phenotype of the inflammatory infiltrate in muscle tissue following acute injury. MAIN METHODS: Forty Wistar rats were submitted to cryoinjury of the tibialis anterior muscle and only half were treated with LIPUS. After 1, 2, 3 and 7 days macrophages and neutrophils were quantified. KEY FINDINGS: With one day, LIPUS led to reductions in the number of neutrophils and M1 macrophages...
November 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Henry Shin, Zach Watkins, Xiaogang Hu
Various neurological conditions, such as stroke or spinal cord injury, result in an impaired control of the hand. One method of restoring this impairment is through functional electrical stimulation (FES). However, traditional FES techniques often lead to quick fatigue and unnatural ballistic movements. In this study, we sought to explore the capabilities of a non-invasive proximal nerve stimulation technique in eliciting various hand grasp patterns. The ulnar and median nerves proximal to the elbow joint were activated transcutanously using a programmable stimulator, and the resultant finger flexion joint angles were recorded using a motion capture system...
November 29, 2017: Scientific Reports
João Alberto Fioravante Tassinary, Adroaldo Lunardelli, Bruno de Souza Basso, Henrique Bregolin Dias, Anderson Velasque Catarina, Simone Stülp, Gabriela Viegas Haute, Bianca Andrade Martha, Denizar Alberto da Silva Melo, Fernanda Bordignon Nunes, Márcio Vinícius Fagundes Donadio, Jarbas Rodrigues de Oliveira
The present study aimed to evaluate the effect of low-intensity pulsed ultrasound (LIPUS) on pre-osteoblast mineralization using in vitro bioassays. Pre-osteoblastic MC3T3-E1 cells were exposed to LIPUS at 1 MHz frequency, 0.2 W/cm2 intensity and 20% duty cycle for 30 min. The analyses were carried out up to 336 h (14 days) after exposure. The concentration of collagen, phosphate, alkaline phosphatase, calcium and transforming growth factor beta 1 (TGF-β1) in cell supernatant and the presence of calcium deposits in the cells were analyzed...
November 22, 2017: Ultrasonics
Kristofer W Loerwald, Michael S Borland, Robert L Rennaker, Seth A Hays, Michael P Kilgard
BACKGROUND: Repeatedly pairing a tone with a brief burst of vagus nerve stimulation (VNS) results in a reorganization of primary auditory cortex (A1). The plasticity-enhancing and memory-enhancing effects of VNS follow an inverted-U response to stimulation intensity, in which moderate intensity currents yield greater effects than low or high intensity currents. It is not known how other stimulation parameters effect the plasticity-enhancing effects of VNS. OBJECTIVE: We sought to investigate the effect of pulse-width and intensity on VNS efficacy...
November 15, 2017: Brain Stimulation
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