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Low-intensity pulsed

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https://www.readbyqxmd.com/read/29781581/brain-correlates-of-continuous-pain-in-rheumatoid-arthritis-as-measured-by-pulsed-arterial-spin-labeling
#1
Yvonne C Lee, Alexander Fine, Ekaterina Protsenko, Elena Massarotti, Robert R Edwards, Ishtiaq Mawla, Vitaly Napadow, Marco L Loggia
OBJECTIVE: Central nervous system pathways involving pain modulation shape the pain experience in patients with chronic pain. Our objectives were to understand the mechanisms underlying pain in rheumatoid arthritis (RA) and identify brain signals that may serve as imaging markers for developing targeted treatments for RA pain. METHODS: Subjects with RA and matched controls underwent functional magnetic resonance imaging, using pulsed arterial spin labeling (pASL)...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29781183/a-comparison-of-1-and-3-2-mhz-low-intensity-pulsed-ultrasound-on-osteogenesis-on-porous-titanium-alloy-scaffolds-an-in-vitro-and-in-vivo-study
#2
Lifang Feng, Xiaohan Liu, Hongjuan Cao, Limei Qin, Wentao Hou, Lin Wu
OBJECTIVES: Low-intensity pulsed ultrasound (LIPUS) combined with porous scaffolds can be used as a new therapy to treat bone defect repair. The aim of this study was to evaluate the effects of 1 and 3.2 MHz LIPUS on osteogenesis on porous Ti64 alloy scaffolds for both in vitro and in vivo studies. METHODS: Scaffolds were randomly divided into the high-frequency ultrasound group, low-frequency ultrasound group, and control group. Mouse pre-osteoblast cells were cultured with porous Ti-6Al-4V scaffolds in vitro to evaluate cell proliferation and differentiation...
May 21, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29781156/effects-of-low-intensity-pulsed-ultrasound-on-radiographic-healing-of-tibial-plateau-leveling-osteotomies-in-dogs-a-prospective-randomized-double-blinded-study
#3
Nina R Kieves, Sherman O Canapp, Peter J Lotsikas, Scott A Christopher, Christopher S Leasure, Debra Canapp, Patrick R Gavin
OBJECTIVE: To determine the influence of low-intensity pulsed ultrasound (LIPUS) on radiographic healing and limb function after uncomplicated, stable osteotomies in dogs. STUDY DESIGN: In vivo, prospective, randomized, double-blinded, placebo-control study. SAMPLE POPULATION: Fifty client-owned dogs. METHODS: Fifty client-owned dogs with naturally occurring unilateral cranial cruciate ligament rupture were enrolled prior to tibial plateau leveling osteotomy...
May 20, 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29775452/the-effects-of-a-pulsed-electromagnetic-field-on-the-proliferation-and-osteogenic-differentiation-of-human-adipose-derived-stem-cells
#4
Yukun Yin, Ping Chen, Qiang Yu, Yan Peng, ZeHao Zhu, Jing Tian
BACKGROUND A low frequency pulsed electromagnetic field (PEMF) has been confirmed to play an important role in promoting the osteogenic differentiation of human bone marrow stem cells (BMSCs). Adipose-derived stem cells (ASCs) possess some attractive characteristics for clinical application compared to BMSCs, such as abundant stem cells from lipoaspirates, faster growth, less discomfort and morbidity during surgery. ASCs can become adipocytes, osteoblasts, chondrocytes, myocytes, neurocytes, and other cell types...
May 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29767241/transcriptome-sequencing-analysis-reveals-the-effect-of-combinative-treatment-with-low%C3%A2-intensity-pulsed-ultrasound-and-magnesium-ions-on-hfob1-19-human-osteoblast-cells
#5
Haiyue Zu, Xueting Yi, Dewei Zhao
Biodegradable magnesium (Mg) materials are considered ideal as osteosynthesis implants. However, clinical application has proven complex. This is primarily associated with the issue of reducing the extent of implant degradation to a range acceptable for the human body, while simultaneously enhancing osteogenesis or osteoinduction. In the present study, a combination of Mg ions and low‑intensity pulsed ultrasound (LIPUS) treatment was applied in hFOB 1.19 human osteoblast cells as a potential strategy to resolve this issue...
May 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29765685/discrepancies-in-the-spiking-threshold-and-frequency-sensitivity-of-nocturnal-moths-explainable-by-biases-in-the-canonical-auditory-stimulation-method
#6
Herve Thevenon, Gerit Pfuhl
The auditory stimulation method used in experiments on moth A cell(s) is generally believed to be adequate to characterize the encoding of bat echolocation signals. The stimulation method hosts, though, several biases. Their compounded effects can explain a range of discrepancies between the reported electrophysiological recordings and significantly alter the current interpretation. To test the hypothesis that the bias may significantly alter our current understanding of the moth's auditory transducer characteristics, papers using the same auditory stimulation method and reporting on either spiking threshold or spiking activity of the moth's A cells were analysed...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29762847/effects-of-fibroblast-growth-factors-2-and-low-intensity-pulsed-ultrasound-on-the-repair-of-knee-articular-cartilage-in-rabbits
#7
Z-F Tang, H-Y Li
OBJECTIVE: To investigate the effect of low intensity ultrasound irradiation combine with fibroblast growth factors (FGF2) on the repair of the knee articular cartilage and to explore its mechanism in rabbit. MATERIALS AND METHODS: The model of the rabbit knee joint injury was established. 40 rabbits were divided into four groups, including control group, model group, FGF2 group and FGF2 + low intensity pulsed ultrasound group (FGF2 + LIPU). The knee joints of rabbits were taken at 4 and 8 weeks, respectively...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29758547/ultrasound-assisted-gene-and-photodynamic-synergistic-therapy-with-multifunctional-foxa1-sirna-loaded-porphyrin-microbubbles-for-enhancing-therapeutic-efficacy-for-breast-cancer
#8
Ranran Zhao, Xiaolong Liang, Bo Zhao, Min Chen, Renfa Liu, Sujuan Sun, Xiuli Yue, Shumin Wang
To improve the non-invasive therapeutic efficacy for ER positive breast cancer (ER+ BC), we fabricated a multifunctional FOXA1 loaded porphyrin microbubble to combine photodynamic therapy (PDT) and gene therapy of FOXA1 knockdown (KD) with ultrasound targeted microbubble destruction (UTMD) technology under the guidance of contrast enhanced ultrasound (CEUS). Cationic porphyrin microbubbles (CpMBs) were firstly fabricated from a porphyrin grafted lipid with two cationic amino groups (PGL-NH2) and fluorocarbon inert gas of C3 F8 ...
May 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29756033/high-flux-soft-x-ray-harmonic-generation-from-ionization-shaped-few-cycle-laser-pulses
#9
Allan S Johnson, Dane R Austin, David A Wood, Christian Brahms, Andrew Gregory, Konstantin B Holzner, Sebastian Jarosch, Esben W Larsen, Susan Parker, Christian S Strüber, Peng Ye, John W G Tisch, Jon P Marangos
Laser-driven high-harmonic generation provides the only demonstrated route to generating stable, tabletop attosecond x-ray pulses but has low flux compared to other x-ray technologies. We show that high-harmonic generation can produce higher photon energies and flux by using higher laser intensities than are typical, strongly ionizing the medium and creating plasma that reshapes the driving laser field. We obtain high harmonics capable of supporting attosecond pulses up to photon energies of 600 eV and a photon flux inside the water window (284 to 540 eV) 10 times higher than previous attosecond sources...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29755590/wide-pulse-high-frequency-low-intensity-neuromuscular-electrical-stimulation-has-potential-for-targeted-strengthening-of-an-intrinsic-foot-muscle-a-feasibility-study
#10
Darren C James, Matthew C Solan, Katya N Mileva
Background: Strengthening the intrinsic foot muscles is a poorly understood and largely overlooked area. In this study, we explore the feasibility of strengthening m . abductor hallucis (AH) with a specific paradigm of neuromuscular electrical stimulation; one which is low-intensity in nature and designed to interleave physiologically-relevant low frequency stimulation with high-frequencies to enhance effective current delivery to spinal motoneurones, and enable a proportion of force produced by the target muscle to be generated from a central origin...
2018: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29744357/cell-fragmentation-and-permeabilization-by-a-1-ns-pulse-driven-triple-point-electrode
#11
Enbo Yang, Joy Li, Michael Cho, Shu Xiao
Ultrashort electric pulses (ns-ps) are useful in gaining understanding as to how pulsed electric fields act upon biological cells, but the electric field intensity to induce biological responses is typically higher than longer pulses and therefore a high voltage ultrashort pulse generator is required. To deliver 1 ns pulses with sufficient electric field but at a relatively low voltage, we used a glass-encapsulated tungsten wire triple-point electrode (TPE) at the interface among glass, tungsten wire, and water when it is immersed in water...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29740016/attosecond-electron-bunches-from-a-nanofiber-driven-by-laguerre-gaussian-laser-pulses
#12
Li-Xiang Hu, Tong-Pu Yu, Zheng-Ming Sheng, Jorge Vieira, De-Bin Zou, Yan Yin, Paul McKenna, Fu-Qiu Shao
Generation of attosecond bunches of energetic electrons offers significant potential from ultrafast physics to novel radiation sources. However, it is still a great challenge to stably produce such electron beams with lasers, since the typical subfemtosecond electron bunches from laser-plasma interactions either carry low beam charge, or propagate for only several tens of femtoseconds. Here we propose an all-optical scheme for generating dense attosecond electron bunches via the interaction of an intense Laguerre-Gaussian (LG) laser pulse with a nanofiber...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737306/pulsed-photoinitiated-fabrication-of-inkjet-printed-titanium-dioxide-reduced-graphene-oxide-nanocomposite-thin-films
#13
Briley Bourgeois, Sijun Luo, Brian Riggs, Yaping Ji, Shiva Adireddy, Kurt Schroder, Stan Farnsworth, Douglas B Chrisey, Matthew Escarra
This work reports a new technique for scalable and low temperature processing of nanostructured-TiO2 thin films, allowing for practical manufacturing of TiO2 based devices such as perovskite solar cells at low temperature or on flexible substrates. Dual layers of dense and mesoporous TiO2/graphitic oxide nanocomposite films are synthesized simultaneously using inkjet printing and pulsed photonic irradiation. Investigation of process parameters including precursor concentration (10-20 wt%) and exposure fluence (4...
May 8, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29733280/motion-tolerant-unfocused-imaging-of-physiological-waveforms-for-blood-pressure-waveform-estimation-using-ultrasound
#14
Joohyun Seo, Sabino J Pietrangelo, Charles G Sodini, Hae-Seung Lee
This paper details unfocused imaging using single-element ultrasound transducers for motion tolerant arterial blood pressure (ABP) waveform estimation. The ABP waveform is estimated based on pulse wave velocity and arterial pulsation through Doppler and M-mode ultrasound. This paper discusses approaches to mitigate the effect of increased clutter due to unfocused imaging on blood flow and diameter waveform estimation. An intensity reduction model (IRM) estimator is described to track the change of diameter, which outperforms a complex cross-correlation model (C3M) estimator in low contrast environments...
May 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/29726530/supercontinuum-generation-at-1-55-%C3%AE-m-in-as-2-s-3-core-photonic-crystal-fiber
#15
Harshul Balani, Ghanshyam Singh, Manish Tiwari, Vijay Janyani, Ashish Kumar Ghunawat
This paper proposes a design and mathematical study of As2 S3 chalcogenide photonic crystal fiber (PCF) for broadband supercontinuum generation. The proposed design offers a large nonlinearity coefficient and ultra-flattened dispersion. The proposed design was analyzed using the full-vectorial finite element method. Through this method, it is shown that an ultra-broad supercontinuum spectrum of 0.8-4.5 μm is attained using an As2 S3 core PCF design with 20 fs pump pulse width and a length of 10 mm, having 3 kW power at a -40  dB spectral and temporal intensity...
May 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29725347/diffusion-tensor-imaging-evaluation-of-neural-network-development-in-patients-undergoing-therapeutic-repetitive-transcranial-magnetic-stimulation-following-stroke
#16
Naoki Yamada, Ryo Ueda, Wataru Kakuda, Ryo Momosaki, Takahiro Kondo, Takuya Hada, Nobuyuki Sasaki, Takatoshi Hara, Atsushi Senoo, Masahiro Abo
We aimed to investigate plastic changes in cerebral white matter structures using diffusion tensor imaging following a 15-day stroke rehabilitation program. We compared the detection of cerebral plasticity between generalized fractional anisotropy (GFA), a novel tool for investigating white matter structures, and fractional anisotropy (FA). Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) of 2400 pulses applied to the nonlesional hemisphere and 240 min intensive occupation therapy (OT) daily over 15 days...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29719274/a-novel-drug-free-strategy-of-nano-pulse-stimulation-sequence-npss-in-oral-cancer-therapy-in-vitro-and-in-vivo-study
#17
Jinsong Guo, Feihong Dong, Lian Ding, Kaile Wang, Jue Zhang, Jing Fang
Nano-pulse stimulation (NPS) is a novel technology to induce cancer apoptosis. In this study, based on the energy-dose effect of NPS, we designed a special NPS sequence (NPSS) with low field intensity. The effectiveness and mechanisms of NPSS on oral cancer therapy were evaluated by cell proliferation assays, microscopic investigation, JC-1 mitochondrial membrane potential assay, tumor inhibition assays, immunohistochemistry (IHC) assay, Ca2+ , NOS and ROS detection assays, respectively. The results demonstrated that NPSS treatment significantly inhibited oral cancer growth in vitro and in vivo...
April 19, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29716488/a-two-centre-observational-study-of-simultaneous-pulse-oximetry-and-arterial-oxygen-saturation-recordings-in-intensive-care-unit-patients
#18
S J Ebmeier, M Barker, M Bacon, R C Beasley, R Bellomo, C Knee Chong, G M Eastwood, J Gilchrist, H Kagaya, J Pilcher, S K Reddy, E Ridgeon, N Sarma, S Spragas, A Tanaka, M Tweedie, M Weatherall, P J Young
The influence of variables that might affect the accuracy of pulse oximetry (SpO<sub>2</sub>) recordings in critically ill patients is not well established. We sought to describe the relationship between paired SpO<sub>2</sub>/SaO<sub>2</sub> (oxygen saturation via arterial blood gas analysis) in adult intensive care unit (ICU) patients and to describe the diagnostic performance of SpO<sub>2</sub> in detecting low SaO<sub>2</sub> and PaO<sub>2</sub>...
May 2018: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/29716343/the-development-of-high-voltage-repetitive-low-jitter-corona-stabilized-triggered-switch
#19
Jiuyuan Geng, Jianhua Yang, Xinbing Cheng, Xiao Yang, Rong Chen
The high-power switch plays an important part in a pulse power system. With the trend of pulse power technology toward modularization, miniaturization, and accuracy control, higher requirements on electrical trigger and jitter of the switch have been put forward. A high-power low-jitter corona-stabilized triggered switch (CSTS) is designed in this paper. This kind of CSTS is based on corona stabilized mechanism, and it can be used as a main switch of an intense electron-beam accelerator (IEBA). Its main feature was the use of an annular trigger electrode instead of a traditional needle-like trigger electrode, taking main and side trigger rings to fix the discharging channels and using SF6 /N2 gas mixture as its operation gas...
April 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29716060/improving-performance-of-differential-pulse-coding-modulation-based-digital-mobile-fronthaul-employing-noise-shaping
#20
Haibo Li, Xiang Li, Ming Luo
A differential pulse coding modulation with noise shaping (NS-DPCM) is proposed to achieve better error vector magnitude (EVM) performance in a digital mobile fronthaul. Compared to previous DPCM based digital mobile fronthaul, a feedback loop combined with a finite-impulse-response (FIR) filter is added to the quantizer of DPCM encoder to operate as a quantization noise shaping technique block. The noise shaping technique increases the signal-to-quantization noise ratio by reshaping the spectrum of the quantization noise...
April 30, 2018: Optics Express
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