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https://www.readbyqxmd.com/read/29669181/racial-disparity-in-oncologic-and-quality-of-life-outcomes-in-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinomas-enrolled-in-a-randomized-phase-2-trial
#1
Margaret K Guerriero, Mary W Redman, Kelsey K Baker, Renato G Martins, Keith Eaton, Laura Q Chow, Rafael Santana-Davila, Christina Baik, Bernardo H Goulart, Sylvia Lee, Cristina P Rodriguez
BACKGROUND: To better understand patient-reported quality of life (PRQOL) for patients with head and neck cancer, PRQOL scores were collected in a clinical trial. METHODS: Patients were randomized to arm A (70 Gy of radiation with cisplatin) or arm B (70 Gy of radiation with cisplatin plus erlotinib at 150 mg daily). PRQOL scores were measured on days -7 (arm B only), 0, 30, and 180 with the University of Washington Quality of Life Questionnaire. Associations with clinical factors and outcomes were explored with linear mixed, logistic, and Cox regression models...
April 18, 2018: Cancer
https://www.readbyqxmd.com/read/29625898/palliative-thoracic-radiation-therapy-for-non-small-cell-lung-cancer-2018-update-of-an-american-society-for-radiation-oncology-astro-evidence-based-guideline
#2
Benjamin Moeller, Ehsan H Balagamwala, Aileen Chen, Kimberly M Creach, Giuseppe Giaccone, Matthew Koshy, Sandra Zaky, George Rodrigues
PURPOSE: To revise the recommendation on the use of concurrent chemotherapy (CC) with palliative thoracic external beam radiation therapy (EBRT) made in the original 2011 American Society for Radiation Oncology guideline on palliative thoracic radiation for lung cancer. METHODS AND MATERIALS: Based on a systematic PubMed search showing new evidence for this key question, the task force felt an update was merited. Guideline recommendations were created using a predefined consensus-building methodology supported by American Society for Radiation Oncology-approved tools for grading evidence quality and recommendation strength...
April 3, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29619778/daikenchuto-for-reducing-postoperative-ileus-in-patients-undergoing-elective-abdominal-surgery
#3
REVIEW
Nobuaki Hoshino, Toshihiko Takada, Koya Hida, Suguru Hasegawa, Toshi A Furukawa, Yoshiharu Sakai
BACKGROUND: Postoperative ileus is a major complication for persons undergoing abdominal surgery. Daikenchuto, a Japanese traditional medicine (Kampo), is a drug that may reduce postoperative ileus. OBJECTIVES: To assess the efficacy and safety of Daikenchuto for reducing prolonged postoperative ileus in persons undergoing elective abdominal surgery. SEARCH METHODS: We searched the following databases on 3 July 2017: CENTRAL, MEDLINE, Embase, ICHUSHI, WHO (World Health Organization) International Clinical Trials Registry Platform (ICTRP), EU Crinical Trials registry (EU-CTR), UMIN Clinical Trials Registry (UMIN-CTR), ClinicalTrials...
April 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29619056/should-molecular-subtype-be-recommended-as-one-of-the-selection-criteria-for-accelerated-partial-breast-irradiation-preliminary-results-from-an-asian-cohort
#4
Tabassum Wadasadawala, Monidipa Mondal, Siji Nojin Paul, Vani Parmar, Nita Nair, Tanuja Shet, Sangeeta Desai, Sudeep Gupta, Rajiv Sarin
Purpose: The purpose of this study was to report clinical outcomes in patients treated with accelerated partial breast irradiation (APBI), stratified as per molecular subtype and American Society for Therapeutic Radiology and Oncology/Groupe Européen de Curiethérapie and European Society for Radiotherapy & Oncology (ASTRO/GEC-ESTRO) patient selection criteria in order to determine whether molecular subtype should be recommended as one of the selection criteria for APBI. Material and methods: 157 early-stage breast cancers patients, treated with APBI using multi-catheter interstitial brachytherapy with ≥ 6 months follow-up were included...
February 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29610962/are-clinical-guidelines-designed-according-to-guidelines-cross-sectional-assessment-of-quality-and-transparency-of-clinical-guidelines-in-urology
#5
Roderick C N van den Bergh, Piet Ost, Christian Surcel, Massimo Valerio, Jurgen J Fütterer, Giorgio Gandaglia, Prasanna Sooriakumaran, Derya Tilki, Igor Tsaur, Guillaume Ploussard
PURPOSE: Guidelines and recommendations become increasingly important in clinical urologic practice. This study aims to inform clinicians using guidelines on how to evaluate the quality of the methodology and transparency of these documents. METHODS: The guidelines on management of castration-resistant prostate cancer of the American Urology Association, European Association of Urology, National Comprehensive Cancer Network, National Institute for Health and Care Excellence, European Society of Medical Oncology were reviewed using the AGREE-II tool (Appraisal of Guidelines for Research and Evaluation)...
April 2, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29608397/optimizing-anticancer-therapy-in-metastatic-non-castrate-prostate-cancer-american-society-of-clinical-oncology-clinical-practice-guideline
#6
Michael J Morris, R Bryan Rumble, Ethan Basch, Sebastien J Hotte, Andrew Loblaw, Dana Rathkopf, Paul Celano, Rick Bangs, Matthew I Milowsky
Purpose This clinical practice guideline addresses abiraterone or docetaxel with androgen-deprivation therapy (ADT) for metastatic prostate cancer that has not been treated (or has been minimally treated) with testosterone-lowering agents. Methods Standard therapy for newly diagnosed metastatic prostate cancer has been ADT alone. Three studies have compared ADT alone with ADT and docetaxel, and two studies have compared ADT alone with ADT and abiraterone. Results Three prospective randomized studies (GETUG-AFU 15, STAMPEDE, and CHAARTED) examined overall survival (OS) with adding docetaxel to ADT...
April 2, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29600223/estrogen-receptor-and-progesterone-receptor-status-of-breast-cancer-patients-of-eastern-india-a-multi-institutional-study
#7
Koushik Chatterjee, Gautam Bhaumik, Bhargab Chattopadhyay
Context: There is a paucity of any significant data on the estrogen receptor (ER) and progesterone receptor (PR) status of breast cancer patients from the eastern part of India. Aims: This study aims to document the ER and PR status of breast cancer patients in the eastern Indian population, as catered by two premier tertiary care hospitals in Kolkata. Subjects and Methods: All breast cancer patients registered between January 1, 2013 and December 31, 2015, in the Departments of Oncology, of IPGMER and SSKM Hospitals and R...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29595316/double-equivocal-her2-invasive-breast-carcinomas-institutional-experience-and-review-of-literature
#8
Brannan B Griffin, Jennifer L Pincus, Kalliopi P Siziopikou, Luis Z Blanco
Context HER2 status is a prognostic factor and therapeutic target in invasive breast carcinomas. Reflex testing using an alternate method is recommended on equivocal cases via immunohistochemistry or fluorescence in situ hybridization (FISH). Therapeutic dilemmas arise when both tests are equivocal. The standard chromosome 17 centromere reference probe (CEP17) is in close proximity to the HER2 locus and may be coamplified, leading to equivocal results. Alternate chromosome 17 reference probes may aid in establishing the true HER2 status...
March 29, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29589987/molecular-testing-guideline-for-the-selection-of-lung-cancer-patients-for-treatment-with-targeted-tyrosine-kinase-inhibitors-american-society-of-clinical-oncology-endorsement-summary-of-the-college-of-american-pathologists-international-association-for-the
#9
https://www.readbyqxmd.com/read/29589051/-chemotherapy-induced-nausea-and-vomiting-current-recommendations-for-prophylaxis
#10
REVIEW
E Storz, J E Gschwend, M Retz
The chemotherapy-induced nausea and vomiting (CINV) is one of the most frequent side effects in cytostatic therapy and a profound challenge during the therapy of cancer patients. Therefore, standardized guideline-orientated prophylaxis is essential and a fundamental contribution for the success of treatment. This review summarizes the current recommendations for CINV of the Multinational Association of Supportive Care in Cancer (MASCC) and European Society of Medical Oncology (ESMO), the American Society for Clinical Oncology (ASCO), the National Comprehensive Cancer Network (NCCN) and the S3-guideline Supportive Therapie of the Leitlinienprogramm Onkologie and shall facilitate its use in the daily routine...
March 27, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29582194/clinical-practice-guidelines-for-fertility-preservation-in-pediatric-adolescent-and-young-adults-with-cancer
#11
REVIEW
Nao Suzuki
In recent years, more cancer patients are achieving long-term survival owing to advances in treatment. However, cancer treatment can cause gonadal dysfunction that leads to loss of fertility. Thus, it is important for clinical oncologists to consider fertility preservation in children, adolescents, and young adults with cancer who are expected to have a favorable outcome and may wish to have children in the future. Sometimes, fertility preservation has to be abandoned depending on the stage of the cancer and the general condition of the patient, because fertility preservation procedures may unacceptably delay cancer treatment or be too risky for the patient...
March 26, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29579316/obstacles-to-improving-outcomes-in-the-treatment-of-uveal-melanoma
#12
REVIEW
Katy K Tsai, Kathryn B Bollin, Sapna P Patel
The rate of advances in uveal melanoma has not kept pace with the rate of advances in cutaneous melanoma. Many patients lack access to or knowledge of specialty centers, and integrated multidisciplinary care between ophthalmology, radiation oncology, and medical oncology is far from the norm. This treatment isolation leads to limited communication about novel clinical trial opportunities. Clinical trials themselves are not widely available, and a lack of robust funding limits rapid and complete investigations...
March 26, 2018: Cancer
https://www.readbyqxmd.com/read/29553283/improving-quality-of-care-in-oncology-through-healthcare-payment-reform
#13
Lonnie Wen, Christine Divers, Melissa Lingohr-Smith, Jay Lin, Scott Ramsey
OBJECTIVES: To provide an overview of alternative payment models (APMs) and describe how leading national organizations involved with oncology care and payment are linking quality improvement initiatives and payment reform. STUDY DESIGN: Literature review. METHODS: For this review, we summarized the literature on APMs and their goals of improving healthcare quality while jointly controlling the cost of care. We described the types of APMs that have been examined in the real-world setting, specifically in the area of oncology, and how they have affected the quality of oncology care...
March 1, 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29545938/the-impact-of-surgical-excision-of-the-primary-tumor-in-stage-iv-breast-cancer-on-survival-a-meta-analysis
#14
Shuangshuang Lu, Jiayi Wu, Yan Fang, Wei Wang, Yu Zong, Xiaosong Chen, Ou Huang, Jian-Rong He, Weiguo Chen, Yafen Li, Kunwei Shen, Li Zhu
Introduction: Approximately 5% of primary breast cancer patients present de novo stage IV breast cancer, for whom systematic therapy is the mainstream treatment. The role of surgical excision of the primary tumor has been controversial due to inconsistent results of relevant studies. Recently, with the reports of some relevant preclinical data, retrospective studies and randomized clinical trials, we've got more evidence to reexamine the issue. Based on those above, a literature review and meta-analysis was performed to determine whether surgery of the primary tumor could improve overall survival in the setting of stage IV breast cancer...
February 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29543933/effect-of-standard-vs-dose-escalated-radiation-therapy-for-patients-with-intermediate-risk-prostate-cancer-the-nrg-oncology-rtog-0126-randomized-clinical-trial
#15
Jeff M Michalski, Jennifer Moughan, James Purdy, Walter Bosch, Deborah W Bruner, Jean-Paul Bahary, Harold Lau, Marie Duclos, Matthew Parliament, Gerard Morton, Daniel Hamstra, Michael Seider, Michael I Lock, Malti Patel, Hiram Gay, Eric Vigneault, Kathryn Winter, Howard Sandler
Importance: Optimizing radiation therapy techniques for localized prostate cancer can affect patient outcomes. Dose escalation improves biochemical control, but no prior trials were powered to detect overall survival (OS) differences. Objective: To determine whether radiation dose escalation to 79.2 Gy compared with 70.2 Gy would improve OS and other outcomes in prostate cancer. Design, Setting, and Participants: The NRG Oncology/RTOG 0126 randomized clinical trial randomized 1532 patients from 104 North American Radiation Therapy Oncology Group institutions March 2002 through August 2008...
March 15, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29543385/vascular-endothelial-growth-factor-vegf-antibody-significantly-increases-the-risk-of-hand-foot-skin-reaction-to-multikinase-inhibitors-mkis-a-systematic-literature-review-and-meta-analysis
#16
Yi Zhu, Xiaochen Zhang, Xiaoe Lou, Min Chen, Peihua Luo, Qiaojun He
With the use of multikinase inhibitors (MKIs) having emerged in recent years, skin toxicities such as hand-foot skin reaction (HFSR) are primary side effects, and they lack effective prediction methods. Here, we updated a previous systematic review by establishing a meta-analysis of the risk of developing HFSR among patients receiving multikinase inhibitors (MKIs) and antivascular endothelial growth factor antibody. Publications from PubMed and abstracts presented at the American Society of Clinical Oncology Annual Meeting up to February 5, 2015 were searched to identify relevant studies, and a total of 236 patients with metastatic tumors in nine trials were included for analysis...
March 15, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29542106/breast-surgery-for-metastatic-breast-cancer
#17
REVIEW
Giuliano Tosello, Maria Regina Torloni, Bruna S Mota, Teresa Neeman, Rachel Riera
BACKGROUND: Metastatic breast cancer is not a curable disease, but women with metastatic disease are living longer. Surgery to remove the primary tumour is associated with an increased survival in other types of metastatic cancer. Breast surgery is not standard treatment for metastatic disease, however several recent retrospective studies have suggested that breast surgery could increase the women's survival. These studies have methodological limitations including selection bias. A systematic review mapping all randomised controlled trials addressing the benefits and potential harms of breast surgery is ideal to answer this question...
March 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29530456/an-overview-of-immune-checkpoint-inhibitors-in-gynecologic-cancers
#18
REVIEW
Tara Castellano, Kathleen N Moore, Laura L Holman
PURPOSE: The goal of this study was to compile a review of topics pertinent to the use of immune checkpoint inhibitors in gynecologic malignancies, including foundation for use, current agents available and trials in gynecologic cancers, special populations of interest, identification and management of toxicities, and considerations in predictive biomarkers and response assessment. METHODS: A literature review of selected topics in reference to immune checkpoint inhibitors and gynecologic cancers was conducted on PubMed and the US Food and Drug Administration drug search application...
March 9, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29529884/provider-tools-for-advance-care-planning-and-goals-of-care-discussion-a-systematic-review
#19
Jeff Myers, Roxanne Cosby, Danusia Gzik, Ingrid Harle, Deb Harrold, Nadia Incardona, Tara Walton
BACKGROUND: Advance care planning and goals of care discussions involve the exploration of what is most important to a person, including their values and beliefs in preparation for health-care decision-making. Advance care planning conversations focus on planning for future health care, ensuring that an incapable person's wishes are known and can guide the person's substitute decision maker for future decision-making. Goals of care discussions focus on preparing for current decision-making by ensuring the person's goals guide this process...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29521235/metastatic-site-location-influences-the-diagnostic-accuracy-of-ctdna-egfr-mutation-testing-in-nsclc-patients-a-pooled-analysis
#20
Francesco Passiglia, Sergio Rizzo, Christian Rolfo, Antonio Galvano, Enrico Bronte, Lorena Incorvaia, Angela Listi, Nadia Barraco, Marta Castiglia, Valentina Calo, Viviana Bazan, Antonio Russo
BACKGROUND: Recent studies evaluated the diagnostic accuracy of circulating tumor DNA (ctDNA) in the detection of epidermal growth factor receptor (EGFR) mutations from plasma of NSCLC patients, overall showing a high concordance as compared to standard tissue genotyping. However it is less clear if the location of metastatic site may influence the ability to identify EGFR mutations in plasma. OBJECTIVE: This pooled analysis aims to evaluate the association between the metastatic site location and the sensitivity of ctDNA analysis in detecting EGFR mutations in NSCLC patients...
March 8, 2018: Current Cancer Drug Targets
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