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https://www.readbyqxmd.com/read/28932384/erratum-to-allergen-immunotherapy-for-insect-venom-allergy-protocol-for-a-systematic-review
#1
Sangeeta Dhami, Ulugbek Nurmatov, Eva-Maria Varga, Gunter Sturm, Antonella Muraro, Cezmi A Akdis, Darío Antolín-Amérigo, M Beatrice Bilò, Danijela Bokanovic, Moises A Calderon, Ewa Cichocka-Jarosz, Joanna N G Oude Elberink, Radoslaw Gawlik, Thilo Jakob, Mitja Kosnik, Joanna Lange, Ervin Mingomataj, Dimitris I Mitsias, Holger Mosbech, Oliver Pfaar, Constantinos Pitsios, Valerio Pravettoni, Graham Roberts, Franziska Ruëff, Betül Ayşe Sin, Aziz Sheikh
[This corrects the article DOI: 10.1186/s13601-016-0095-x.].
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28916424/predictors-of-epinephrine-dispensing-and-allergy-follow-up-after-emergency-department-visit-for-anaphylaxis
#2
Megan Motosue, M Fernanda Bellolio, Holly K Van Houten, Nilay D Shah, Ronna L Campbell
BACKGROUND: National guidelines recommend that patients with anaphylaxis be prescribed an epinephrine auto-injector (EAI) and referred to an allergy/immunology (A/I) specialist. OBJECTIVE: To evaluate guideline concordance and identify predictors of EAI dispensing and A/I follow-up in patients with anaphylaxis treated in the emergency department (ED). METHODS: We identified patients seen in the ED for anaphylaxis from 2010 through 2014 from an administrative claims database using an expanded International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code algorithm...
September 12, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28902950/pre-emptive-evaluation-of-venom-allergy-in-a-patient-with-systemic-mastocytosis
#3
Theo Gülen, Cem Akin
No abstract text is available yet for this article.
September 13, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28888247/fatal-anaphylaxis-mortality-rate-and-risk-factors
#4
Paul J Turner, Elina Jerschow, Thisanayagam Umasunthar, Robert Lin, Dianne E Campbell, Robert J Boyle
Up to 5% of the US population has suffered anaphylaxis. Fatal outcome is rare, such that even for people with known venom or food allergy, fatal anaphylaxis constitutes less than 1% of total mortality risk. The incidence of fatal anaphylaxis has not increased in line with hospital admissions for anaphylaxis. Fatal drug anaphylaxis may be increasing, but rates of fatal anaphylaxis to venom and food are stable. Risk factors for fatal anaphylaxis vary according to cause. For fatal drug anaphylaxis, previous cardiovascular morbidity and older age are risk factors, with beta-lactam antibiotics, general anesthetic agents, and radiocontrast injections the commonest triggers...
September 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28881055/individual-healthcare-plan-for-allergic-children%C3%A2-at-school-lessons-from-a-2015-2016-school-year-survey
#5
Guillaume Pouessel, Stépanie Lejeune, Marie-Pierre Dupond, Annie Renard, Camille Fallot, Antoine Deschildre
The Individual Healthcare Plan (IHP) was implemented in schools in France in 2003 to improve management of allergic children. Our objectives were to assess the practical aspects of IHP (excluding asthma) and allergic reactions occurring at school. METHODS: Prospective study conducted in the North Department (France) during the 2015/2016 school-year. Two questionnaires were developed: one for the school doctors (n=67) and one for the school principals (n=2372). RESULTS: Data from 336 (25%) of the 1325 IHPs (0...
September 7, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28837089/heterologous-expression-purification-and-immunoreactivity-of-the-antigen-5-from-polybia-paulista-wasp-venom
#6
Murilo Luiz Bazon, Amilcar Perez-Riverol, José Roberto Aparecido Dos Santos-Pinto, Luis Gustavo Romani Fernandes, Alexis Musacchio Lasa, Débora Laís Justo-Jacomini, Mario Sergio Palma, Ricardo de Lima Zollner, Márcia Regina Brochetto-Braga
Polybia paulista (Hymenoptera: Vespidae) is responsible for a high number of sting accidents and anaphylaxis events in Southeast Brazil, Argentina and Paraguay. The specific detection of allergy to the venom of this wasp is often hampered by the lack of recombinant allergens currently available for molecular diagnosis. Antigen 5 (~23 kDa) from P. paulista venom (Poly p 5) is a highly abundant and glycosylated allergenic protein that could be used for development of component-resolved diagnosis (CRD). Here, we describe the cloning and heterologous expression of the antigen 5 (rPoly p 5) from P...
August 24, 2017: Toxins
https://www.readbyqxmd.com/read/28802075/overcoming-severe-adverse-reactions-to-venom-immunotherapy-by-using-anti-ige-antibodies-in-combination-with-a-high-maintenance-dose
#7
Eva Stretz, Eva Maria Oppel, Räwer Helen-Caroline, René Chatelain, Sebastian Mastnik, Bernhard Przybilla, Franziska Ruëff
BACKGROUND: An omalizumab treatment and a high maintenance venom dose may both help to prevent recurrent systemic allergic reactions (SAR) to venom immunotherapy (VIT). The effectiveness of this combination therapy, however, is unclear. OBJECTIVE: We wanted to explore the possibility whether a temporary treatment with the anti-IgE antibody omalizumab, combined with a VIT using an elevated maintenance dose of >100 μg venom may establish a permanent tolerance of maintenance VIT...
August 12, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28796123/hymenoptera-induced-anaphylaxis-is-it-a-mast-cell-driven-hematological-disorder
#8
Knut Brockow, Cem Akin
PURPOSE OF REVIEW: Hymenoptera-induced allergy (HVA) is a common cause of anaphylaxis and may be fatal. It is associated with systemic mastocytosis in about 7% of adult patients. Systemic mastocytosis is a proliferative disorder of hematopoietic mast cell progenitors. There is recent data on the association between systemic mastocytosis and HVA. RECENT FINDINGS: Hymenoptera venoms are the most common immunoglobulin E-mediated elicitors of anaphylaxis in patients with mastocytosis...
August 8, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28796121/climate-changes-and-hymenoptera-venom-allergy-are-there-some-connections
#9
Stefano Turillazzi, Francesco Turillazzi
PURPOSE OF REVIEW: This review aims to update the world status of the main allergenic stinging Hymenoptera. RECENT FINDINGS: In this review, we consider the problems that social Hymenoptera (bees, wasps and ants) could represent in the nearest future for human health in different parts of the world. SUMMARY: Distribution and consistency of allergenic species including venomous insects are interested by accelerated dynamics caused by climate changes and globalization...
October 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28759475/component-resolved-diagnostics-for-hymenoptera-venom-allergy
#10
Thilo Jakob, Ulrich Müller, Arthur Helbling, Edzard Spillner
PURPOSE OF REVIEW: Component-resolved diagnostics makes use of defined allergen molecules to analyse IgE-mediated sensitizations at a molecular level. Here, we review recent studies on the use of component-resolved diagnostics in the field of Hymenoptera venom allergy (HVA) and discuss its benefits and limitations. RECENT FINDINGS: Component resolution in HVA has moved from single molecules to panels of allergens. Detection of specific immunoglobulin E (sIgE) to marker and cross-reactive venom allergens has been reported to facilitate the discrimination between primary sensitization and cross-reactivity and thus, to provide a better rationale for prescribing venom immunotherapy (VIT), particularly in patients sensitized to both honeybee and vespid venom...
October 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28756081/temporal-trends-in-epinephrine-dispensing-and-allergy-immunology-follow-up-among-emergency-department-anaphylaxis-patients-in-the-united-states-2005-2014
#11
Megan S Motosue, M Fernanda Bellolio, Holly K Van Houten, Nilay D Shah, Venkatesh R Bellamkonda, David M Nestler, Ronna L Campbell
BACKGROUND: Anaphylaxis is a potentially life-threatening allergic reaction; measures including prescription of an epinephrine autoinjector (EAI) and allergy/immunology (A/I) follow-up may prevent future morbidity. OBJECTIVE: The objective of this study was to evaluate trends in outpatient management of anaphylaxis by studying EAI dispensing and A/I follow-up among patients seen in the emergency department (ED) for anaphylaxis from 2005 through 2014. METHODS: We analyzed administrative claims data from the OptumLabs Data Warehouse database using an expanded International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code algorithm...
September 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28748641/eaaci-guidelines-on-allergen-immunotherapy-hymenoptera-venom-allergy
#12
Gunter J Sturm, Eva-Maria Varga, Graham Roberts, Holger Mosbech, M Beatrice Bilò, Cezmi A Akdis, Darío Antolín-Amérigo, Ewa Cichocka-Jarosz, Radoslaw Gawlik, Thilo Jakob, Mitja Kosnik, Joanna Lange, Ervin Mingomataj, Dimitris I Mitsias, Markus Ollert, Joanna N G Oude Elberink, Oliver Pfaar, Constantinos Pitsios, Valerio Pravettoni, Franziska Ruëff, Betül Ayşe Sin, Ioana Agache, Elizabeth Angier, Stefania Arasi, Moises A Calderón, Montserrat Fernandez-Rivas, Susanne Halken, Marek Jutel, Susanne Lau, Giovanni B Pajno, Ronald van Ree, Dermot Ryan, Otto Spranger, Roy Gerth van Wijk, Sangeeta Dhami, Hadar Zaman, Aziz Sheikh, Antonella Muraro
Hymenoptera venom allergy is a potentially life-threatening allergic reaction following a honeybee, vespid or ant sting. Systemic allergic sting reactions have been reported in up to 7.5% of adults and up to 3.4% of children. They can be mild and restricted to the skin or moderate-to-severe with a risk of life-threatening anaphylaxis. Patients should carry an emergency kit containing an adrenaline autoinjector, H1 -antihistamines, and corticosteroids depending on the severity of their previous sting reaction(s)...
July 27, 2017: Allergy
https://www.readbyqxmd.com/read/28739022/component-resolved-diagnosis-in-hymenoptera-allergy
#13
REVIEW
D Antolín-Amérigo, B Ruiz-León, E Boni, T Alfaya-Arias, M Álvarez-Mon, J Barbarroja-Escudero, D González-de-Olano, C Moreno-Aguilar, M Rodríguez-Rodríguez, M J Sánchez-González, L Sánchez-Morillas, A Vega-Castro
Component-resolved diagnosis based on the use of well-defined, properly characterised and purified natural and recombinant allergens constitutes a new approach in the diagnosis of venom allergy. Prospective readers may benefit from an up-to-date review on the allergens. The best characterised venom is that of Apis mellifera, whose main allergens are phospholipase A2 (Api m1), hyaluronidase (Api m2) and melittin (Api m4). Additionally, in recent years, new allergens of Vespula vulgaris have been identified and include phospholipase A1 (Ves v1), hyaluronidase (Ves v2) and antigen 5 (Ves v5)...
July 21, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28718981/health-economic-analysis-of-allergen-immunotherapy-ait-for-the-management-of-allergic-rhinitis-asthma-food-allergy-and-venom-allergy-a-systematic-overview
#14
REVIEW
Miqdad Asaria, Sangeeta Dhami, Ronald van Ree, Roy Gerth van Wijk, Antonella Muraro, Graham Roberts, Aziz Sheikh
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is developing guidelines for allergen immunotherapy (AIT) for the management of allergic rhinitis, allergic asthma, IgE-mediated food allergy and venom allergy. To inform the development of clinical recommendations, we undertook systematic reviews to critically assess evidence on the effectiveness, safety and cost-effectiveness of AIT for these conditions. This paper focusses on synthesizing data and gaps in the evidence on the cost-effectiveness of AIT for these conditions...
July 18, 2017: Allergy
https://www.readbyqxmd.com/read/28712914/ige-cross-reactivity-of-phospholipase-a2-and-hyaluronidase-of-apis-dorsata-giant-asian-honeybee-and-apis-mellifera-western-honeybee-venom-possible-use-of-a-%C3%A2-mellifera-venom-for-diagnosis-of-patients-allergic-to-a-%C3%A2-dorsata-venom
#15
Peshala Gunasekara, S M Handunnetti, Sunil Premawansa, E W R A Witharana, W M D K Dasanayake, Indra P Ratnayake, Suranjith L Seneviratne, R K S Dias, G A S Premakumara, Rajiva de Silva
Diagnostic and therapeutic reagents are unavailable for anaphylaxis arising from stings by Apis dorsata. Venom profiles and cross-reactivity of A. dorsata and Apis mellifera were compared, to ascertain whether venom of A. mellifera can be used for diagnosis in A. dorsata allergy. Both venom profiles were similar by High Performance Liquid Chromatography and SDS-PAGE. Sera of 29 of 30 (96.7%) patients with anaphylaxis to A. dorsata stings had IgE to the phospholipase-2 (PLA2) doublet (15 and 16 kDa) of A...
July 14, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28706538/safety-of-100%C3%A2-%C3%A2%C2%B5g-venom-immunotherapy-rush-protocols-in-children-compared-to-adults
#16
Johanna Stoevesandt, Christine Hosp, Andreas Kerstan, Axel Trautmann
BACKGROUND: There is a paucity of studies examining the safety of venom immunotherapy (VIT) in children. We aimed to assess the incidence of anaphylactic side effects during rush VIT in a cohort of pediatric patients and adult controls. METHODS: 72 consecutive cycles of VIT-buildup in 71 children/adolescents aged 7-17 years were retrospectively evaluated and compared to an adult control group (n = 981) with regard to baseline parameters (sex, causative venom, severity of index sting reaction, results of allergy testing, comorbidities) and the incidence of anaphylactic adverse reactions...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28686638/which-immunotherapy-product-is-better-for-patients-allergic-to-polistes-venom-a-laboratory-and-clinical-study
#17
Eleonora Savi, Cristoforo Incorvaia, Elisa Boni, Marina Mauro, Silvia Peveri, Valerio Pravettoni, Oliviero Quercia, Federico Reccardini, Marcello Montagni, Laura Pessina, Erminia Ridolo
BACKGROUND: Venom immunotherapy (VIT) is highly effective in preventing allergic reactions to insect stings, but the appropriate venom must be used to achieve clinical protection. In patients with multiple positive results to venoms, molecular allergy diagnostics or CAP-inhibition may identify the causative venom. Concerning allergy to venom from Polistes spp. it has been proposed that only the European species P. dominulus should be used for VIT. However, this recommendation is not present in any international guideline...
2017: PloS One
https://www.readbyqxmd.com/read/28680374/the-role-of-lipids-in-development-of-allergic-responses
#18
REVIEW
Manuel Gómez Del Moral, Eduardo Martínez-Naves
Most allergic diseases are caused by activation of Th2 type immune responses resulting in the production of specific IgE against proteins found in normally harmless substances such as pollen, mites, epithelia or food. Allergenic substances are composed, in addition to proteins, of other compounds such as carbohydrates and lipids. Those lipids are able to promote the development of Th2-type responses associated with allergy. There are lipids found in pollen, milk or insect venom that are specifically recognized by CD1 restricted unconventional T lymphocytes, which can promote allergic reactions...
June 2017: Immune Network
https://www.readbyqxmd.com/read/28675375/specific-immunotherapy-in-hymenoptera-venom-allergy-and-concomitant-malignancies-a-retrospective-follow-up-focusing-on-efficacy-and-safety
#19
J Aeberhard, G Haeberli, U R Müller, A Helbling
BACKGROUND: Malignancies are often considered as a contraindication for allergen specific immunotherapy. This aspect must be discussed in regards to the population with severe Hymenoptera venom allergy and cancer. The aim of this retrospective study was to conduct a further examination of patients with Hymenoptera venom allergy, venom immunotherapy (VIT) and a malignancy. Methodology: All patients have been included who were referred for evaluation of a Hymenoptera venom allergy or for control during VIT from January 1, 2004 to December 31, 2008...
July 4, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28638279/preventive-actions-of-allergen-immunotherapy-the-facts-and-the-effects-in-search-of-evidence
#20
REVIEW
Irene Martignago, Cristoforo Incorvaia, Erminia Ridolo
Allergen immunotherapy (AIT) is the only treatment that works on the causes of allergy. Available AIT nowadays are subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) for allergic rhinitis and asthma, while for allergy to Hymenoptera venom only subcutaneous route is recommended. A bulk of trials and meta-analyses demonstrated that efficacy and safety of AIT in decreasing allergic clinical symptoms and use of rescue medications, while its preventive capacity is yet under investigation. The most important of these effects is the prevention of potentially fatal anaphylactic reactions to Hymenoptera stings by venom immunotherapy (VIT)...
2017: Clinical and Molecular Allergy: CMA
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