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Venom allergy

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https://www.readbyqxmd.com/read/28273336/questionable-diagnostic-benefit-of-the-commercially-available-panel-of-bee-venom-components
#1
Lisa Arzt, Danijela Bokanovic, Christoph Schrautzer, Ines Schwarz, Karin Laipold, Werner Aberer, Gunter Sturm
For many years, only the major allergen rApi-m-1 has been available on the ImmunoCAP system for routine diagnosis of bee venom (BV) allergy. Now, there are 5 components available and we aimed to detect sensitivity and specificity of rApi m 1, 2, 3, 5 and 10 in BV allergic patients. We further evaluated sensitivity of rApi-m-1 and 2 of an alternative platform and investigated possible differences in the sensitization profile between monosensitization and clinically relevant double sensitization. Analysis of the whole panel of BV allergens of the CAP system still resulted in a lower sensitivity than the combination of rApi-m-1 and 2 of the Immulite (71...
March 8, 2017: Allergy
https://www.readbyqxmd.com/read/28257631/clinical-practice-recommendations-for-allergen-specific-immunotherapy-in-children-the-italian-consensus-report
#2
REVIEW
Giovanni Battista Pajno, Roberto Bernardini, Diego Peroni, Stefania Arasi, Alberto Martelli, Massimo Landi, Giovanni Passalacqua, Antonella Muraro, Stefania La Grutta, Alessandro Fiocchi, Luciana Indinnimeo, Carlo Caffarelli, Elisabetta Calamelli, Pasquale Comberiati, Marzia Duse
Allergen-specific immunotherapy (AIT) is currently recognized as a clinically effective treatment for allergic diseases, with a unique disease-modifying effect. AIT was introduced in clinical practice one century ago, and performed in the early years with allergenic extracts of poor quality and definition. After the mechanism of allergic reaction were recognized, the practice of AIT was refined, leading to remarkable improvement in the efficacy and safety profile of the treatment. Currently AIT is accepted and routinely prescribed worldwide for respiratory allergies and hymenoptera venom allergy...
January 23, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28211342/key-issues-in-hymenoptera-venom-allergy-an-update
#3
REVIEW
T Alfaya Arias, V Soriano Gómis, T Soto Mera, A Vega Castro, J M Vega Gutiérrez, A Alonso Llamazares, D Antolín Amérigo, F J Carballada Gonzalez, C Dominguez Noche, D Gutierrez Fernandez, L Marques Amat, A Martinez Arcediano, M Martinez San Ireneo, A Moreno Ancillo, Y Puente Crespo, B Ruiz Leon, L Sánchez Morillas
In this review, the Hymenoptera Allergy Committee of the SEAIC analyzes the most recent scientific literature addressing problems related to the diagnosis of hymenoptera allergy and to management of venom immunotherapy. Molecular diagnosis and molecular risk profiles are the key areas addressed. The appearance of new species of hymenoptera that are potentially allergenic in Spain and the associated diagnostic and therapeutic problems are also described. Finally, we analyze the issue of mast cell activation syndrome closely related to hymenoptera allergy, which has become a new diagnostic challenge for allergists given its high prevalence in patients with venom anaphylaxis...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28193791/epinephrine-for-first-aid-management-of-anaphylaxis
#4
Scott H Sicherer, F Estelle R Simons
Anaphylaxis is a severe, generalized allergic or hypersensitivity reaction that is rapid in onset and may cause death. Epinephrine (adrenaline) can be life-saving when administered as rapidly as possible once anaphylaxis is recognized. This clinical report from the American Academy of Pediatrics is an update of the 2007 clinical report on this topic. It provides information to help clinicians identify patients at risk of anaphylaxis and new information about epinephrine and epinephrine autoinjectors (EAs). The report also highlights the importance of patient and family education about the recognition and management of anaphylaxis in the community...
March 2017: Pediatrics
https://www.readbyqxmd.com/read/28120601/hymenoptera-venom-allergy-a-closer-collaboration-is-needed-between-allergists-and-emergency-physicians
#5
A Ciccarelli, C Calabrò, C Imperatore, G Scala
Background. Hymenoptera stings are sometimes fatal in venom-allergic patients. Fatalities mostly occur in previously stung subjects, especially those with a history of systemic reactions, and could be avoided if patients were properly informed of the existence of a prevention strategy for insect stings, referred to an allergy follow-up and prescribed auto-injectable epinephrine and/or venom-specific immunotherapy (VIT). We sought to assess knowledge and awareness of Hymenoptera Venom Allergy (HVA) in a small sample of Emergency Physicians in our geographic area...
January 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28120424/allergen-immunotherapy-for-insect-venom-allergy-a-systematic-review-and-meta-analysis
#6
REVIEW
S Dhami, H Zaman, E-M Varga, G J Sturm, A Muraro, C A Akdis, D Antolín-Amérigo, M B Bilò, D Bokanovic, M A Calderon, E Cichocka-Jarosz, J N G Oude Elberink, R Gawlik, T Jakob, M Kosnik, J Lange, E Mingomataj, D I Mitsias, H Mosbech, M Ollert, O Pfaar, C Pitsios, V Pravettoni, G Roberts, F Ruëff, B A Sin, M Asaria, G Netuveli, A Sheikh
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines on Allergen Immunotherapy (AIT) for the management of insect venom allergy. To inform this process, we sought to assess the effectiveness, cost-effectiveness and safety of AIT in the management of insect venom allergy. METHODS: We undertook a systematic review, which involved searching 15 international biomedical databases for published and unpublished evidence...
November 6, 2016: Allergy
https://www.readbyqxmd.com/read/28105558/immunology-of-bee-venom
#7
REVIEW
Daniel Elieh Ali Komi, Farzaneh Shafaghat, Ricardo D Zwiener
Bee venom is a blend of biochemicals ranging from small peptides and enzymes to biogenic amines. It is capable of triggering severe immunologic reactions owing to its allergenic fraction. Venom components are presented to the T cells by antigen-presenting cells within the skin. These Th2 type T cells then release IL-4 and IL-13 which subsequently direct B cells to class switch to production of IgE. Generating venom-specific IgE and crosslinking FcεR1(s) on the surface of mast cells complete the sensitizing stage in allergic individuals who are most likely to experience severe and even fatal allergic reactions after being stung...
January 20, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28073614/underuse-of-allergy-services-for-patients-having-systemic-reactions-to-hymenoptera-venom-stings
#8
Anil M Patel, Vivian Wang, Ami Philipp, Joseph S Yusin
No abstract text is available yet for this article.
March 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28034659/toxins-and-pharmacologically-active-compounds-from-species-of-the-family-bufonidae-amphibia-anura
#9
REVIEW
Candelario Rodríguez, Louise Rollins-Smith, Roberto Ibáñez, Armando A Durant-Archibold, Marcelino Gutiérrez
ETHNOPHARMACOLOGICAL RELEVANCE: Among amphibians, 15 of the 47 species reported to be used in traditional medicines belong to the family Bufonidae, which demonstrates their potential in pharmacological and natural products research. For example, Asian and American tribes use the skin and the parotoid gland secretions of some common toads in the treatment of hemorrhages, bites and stings from venomous animals, skin and stomach disorders, as well as several types of cancers. OVERARCHING OBJECTIVE: In addition to reviewing the occurrence of chemical constituents present in the family Bufonidae, the cytotoxic and biomedical potential of the active compounds produced by different taxa are presented...
December 26, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28007089/epidemiology-of-anaphylaxis-at-a-tertiary-care-center-a-report-of-730-cases
#10
Alexei Gonzalez-Estrada, Stacy K Silvers, Asaf Klein, Katrina Zell, Xiao-Feng Wang, David M Lang
BACKGROUND: Recent data reveal that the rate of anaphylaxis is increasing and suggest that idiopathic anaphylaxis may account for most of these cases. OBJECTIVE: To determine the pattern of anaphylaxis at a tertiary care referral center. METHODS: A retrospective electronic medical record review spanning 12 years (2002-2013) identified patients with anaphylaxis. RESULTS: Of the 4,777 records reviewed, 730 patients met our anaphylaxis definition...
January 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27996943/insect-venom-immunotherapy-analysis-of-the-safety-and-tolerance-of-3-buildup-protocols-frequently-used-in-spain
#11
D Gutiérrez Fernández, A Moreno-Ancillo, S Fernández Meléndez, C Domínguez-Noche, P Gálvez Ruiz, T Alfaya Arias
INTRODUCTION: Hymenoptera venom immunotherapy (VIT) is an effective treatment but not one devoid of risk, as both local and systemic adverse reactions may occur, especially in the initial phases. We compared the tolerance to 3 VIT buildup protocols and analyzed risk factors associated with adverse reactions during this phase. MATERIALS AND METHODS: We enrolled 165 patients divided into 3 groups based on the buildup protocol used (3, 4, and 9 weeks). The severity of systemic reactions was evaluated according to the World Allergy Organization model...
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27996941/ige-api-m-4-is-useful-for-identifying-a-particular-phenotype-of-bee-venom-allergy
#12
B Ruiz, P Serrano, C Moreno
BACKGROUND AND OBJECTIVE: Different clinical behaviors have been identified in patients allergic to bee venom. Compound-resolved diagnosis could be an appropriate tool for investigating these differences. The aims of this study were to analyze whether specific IgE to Api m 4 (sIgE-Api m 4) can identify a particular kind of bee venom allergy and to describe response to bee venom immunotherapy (bVIT). METHODS: Prospective study of 31 patients allergic to bee venom who were assigned to phenotype group A (sIgE-Api m 4 <0...
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27993877/specific-immunoglobulin-ig-g-reference-intervals-for-common-food-insect-and-mold-allergens
#13
Thomas B Martins, Michael E Bandhauer, Diane M Wilcock, Harry R Hill, Patricia R Slev
BACKGROUND: The clinical utility of serum IgG measurement in the diagnosis of allergy and food-induced hypersensitivity has been largely discredited. Recent studies, however, have shown that specific IgG can inhibit IgE mediated allergies, and may play a role in allergen specific desensitization. Accurate reference intervals for IgG specific allergens have not been widely established and are needed for better interpretation of serum antibody concentrations. In this study we established 64 IgG reference intervals for 48 common food allergens, 5 venoms, and 11 molds...
December 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27986410/simplification-of-intradermal-skin-testing-in-hymenoptera-venom-allergic-children
#14
Ewa Cichocka-Jarosz, Marcin Stobiecki, Piotr Brzyski, Iwona Rogatko, Marita Nittner-Marszalska, Krystyna Sztefko, Ewa Czarnobilska, Grzegorz Lis, Anna Nowak-Węgrzyn
BACKGROUND: The direct comparison between children and adults with Hymenoptera venom anaphylaxis (HVA) has never been extensively reported. Severe HVA with IgE-documented mechanism is the recommendation for venom immunotherapy, regardless of age. OBJECTIVE: To determine the differences in the basic diagnostic profile between children and adults with severe HVA and its practical implications. METHODS: We reviewed the medical records of 91 children and 121 adults...
March 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27924689/hymenoptera-venom-allergy-in-outdoor-workers-occupational-exposure-clinical-features-and-effects-of-allergen-immunotherapy
#15
Alessandra Toletone, Susanna Voltolini, Giovanni Passalacqua, Guglielmo Dini, Donatella Bignardi, Paola Minale, Emanuela Massa, Alessio Signori, Costantino Troise, Paolo Durando
OBJECTIVES: To describe (i) the clinical characteristics of workers, exposed to hymenoptera stings, with an ascertained diagnosis of Hymenoptera Venom Allergy (HVA), (ii) the specific role of occupational exposure, (iii) the effect of Venom Immunotherapy (VIT) in reducing the severity of allergic episodes in workers exposed to repeated stings of hymenoptera, and (iv) the management of the occupational consequences caused by allergic reactions due to hymenoptera stings. METHODS: Between 2000 and 2013 an observational study, including patients referred to the regional reference hospital of Liguria, Italy, with an ascertained diagnosis of HVA and treated with VIT, was performed...
February 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27914814/rush-venom-immunotherapy-in-children
#16
Ronit Confino-Cohen, Yossi Rosman, Arnon Goldberg
BACKGROUND: Rush venom immunotherapy (VIT) is highly effective in Hymenoptera venom allergy. Still, specific data regarding its safety and efficiency in children are rather sparse. OBJECTIVES: The objective of this study was to better evaluate the safety and efficiency of rush VIT in this specific age group. METHODS: Children younger than 16 years with systemic reaction to insect sting involving, at least, one body system other than skin and children aged 16-18 years with any kind of systemic reaction were offered conventional or rush VIT with a build-up phase that lasted 3 days...
November 30, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27907922/distinct-contributory-factors-determine-basophil-allergen-sensitivity-in-grass-pollen-rhinitis-and-in-anaphylactic-wasp-venom-allergy
#17
Peter Korošec, Mira Šilar, Peter Kopač, Renato Eržen, Mihaela Zidarn, Mitja Košnik
BACKGROUND: We sought to determine whether basophil-allergen sensitivity could be transferred to donor basophils by passive IgE sensitisation in allergic rhinitis and anaphylactic Hymenoptera venom hypersensitivity. METHODS: We studied 15 wasp venom-, 19 grass pollen- and 2 house dust mite-allergic patients, 2 healthy donors, and 8 wasp venom-allergic donors. In all subjects, we first evaluated the initial basophil response to wasp venom, grass pollen, or house dust mite allergen...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27903075/australian-taipan-oxyuranus-spp-envenoming-clinical-effects-and-potential-benefits-of-early-antivenom-therapy-australian-snakebite-project-asp-25
#18
Christopher I Johnston, Nicole M Ryan, Margaret A O'Leary, Simon G A Brown, Geoffrey K Isbister
CONTEXT: Taipans (Oxyuranus spp.) are medically important venomous snakes from Australia and Papua New Guinea. The objective of this study was to describe taipan envenoming in Australian and its response to antivenom. METHODS: Confirmed taipan bites were recruited from the Australian Snakebite Project. Data were collected prospectively on all snakebites, including patient demographics, bite circumstances, clinical effects, laboratory results, complications and treatment...
February 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/27826019/molecular-cloning-expression-and-ige-immunoreactivity-of-phospholipase-a1-a-major-allergen-from-polybia-paulista-hymenoptera-vespidae-venom
#19
Amilcar Perez-Riverol, Franco Dani Campos Pereira, Alexis Musacchio Lasa, Luis Gustavo Romani Fernandes, José Roberto Aparecido Dos Santos-Pinto, Débora Lais Justo-Jacomini, Gabriel Oliveira de Azevedo, Murilo Luiz Bazon, Mario Sergio Palma, Ricardo de Lima Zollner, Márcia Regina Brochetto-Braga
Polybia paulista (Hymenoptera: Vespidae) is a clinically relevant social wasp that frequently causes stinging accidents in southeast Brazil. To date, diagnosis and specific immunotherapy (SIT) of allergy are based on the use of crude venom extracts. Production of recombinant forms of major allergens from P. paulista venom will improve diagnosis and SIT of allergic patients by reducing the incidence of cross-reactivity and non-specific sensitization. Here, we describe the molecular cloning, heterologous expression, purification and IgE-mediated immunodetection of phospholipase A1 (Poly p 1), a major allergen from P...
December 15, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27790249/cloning-structural-modelling-and-characterization-of-vest2s-a-wasp-venom-hyaluronidase-haase-from-vespa-tropica
#20
Prapenpuksiri Rungsa, Paroonkorn Incamnoi, Sophida Sukprasert, Nunthawun Uawonggul, Sompong Klaynongsruang, Jureerut Daduang, Rina Patramanon, Sittiruk Roytrakul, Sakda Daduang
BACKGROUND: Wasp venom is a complex mixture containing proteins, enzymes and small molecules, including some of the most dangerous allergens. The greater banded wasp (Vespa tropica) is well-known for its lethal venom, whose one of the major components is a hyaluronidase (HAase). It is believed that the high protein proportion and activity of this enzyme is responsible for the venom potency. METHODS: In the present study, cDNA cloning, sequencing and 3D-structure of Vespa tropica venom HAase were described...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
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