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Venom allergy

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https://www.readbyqxmd.com/read/29768265/disease-burden-psychological-well-being-and-attitudes-regarding-the-set-of-emergency-medication-in-adults-with-insect-venom-allergy
#1
Marthe-Lisa Schaarschmidt, Mandy Gutknecht, Lisa Schoeben, Astrid Schmieder
BACKGROUND: Insect venom allergy is common and greatly impairs patients' quality of life. Additionally, low compliance with carrying emergency medication is reported. The aim of our study was to analyze the disease burden, levels of anxiety and depression, and to evaluate attitudes towards the set of emergency medication in affected patients. METHODS: Between April 2016 and January 2017, patients ≥18 years visiting our department because of an insect venom allergy were asked to complete a paper-based questionnaire...
May 16, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29757238/the-initiation-of-th2-immunity-towards-food-allergens
#2
REVIEW
Yosef Ellenbogen, Rodrigo Jiménez-Saiz, Paul Spill, Derek K Chu, Susan Waserman, Manel Jordana
In contrast with Th1 immune responses against pathogenic viruses and bacteria, the incipient events that generate Th2 responses remain less understood. One difficulty in the identification of universal operating principles stems from the diversity of entities against which cellular and molecular Th2 responses are produced. Such responses are launched against harmful macroscopic parasites and noxious substances, such as venoms, but also against largely innocuous allergens. This suggests that the established understanding about sense and recognition applied to Th1 responses may not be translatable to Th2 responses...
May 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29732291/venom-allergy-risk-factors-for-systemic-reactions-and-the-knowledge-levels-among-turkish-beekeepers
#3
Dane Ediger, Kadriye Terzioglu, Raziye Tulumen Ozturk
Background: Allergic reactions developing after bee sting can be severe and life-threatening. According to epidemiological data, serious systemic reactions range between 1.2%-3%, and this is 2-3 times higher (6%) in beekeeping. In different beekeepers' populations, risk factors of systemic reactions have been investigated and diverse results have been found. Objective: The aim of this study is to evaluate the level of knowledge of beekeepers about venom allergy, epidemiological data, systemic reaction rates, risk factors for systemic reactions, and the rate of emergency admissions after bee sting...
April 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29715467/diversity-of-peptidic-and-proteinaceous-toxins-from-social-hymenoptera-venoms
#4
José Roberto Aparecido Dos Santos-Pinto, Amilcar Perez-Riverol, Alexis Musacchio Lasa, Mario Sergio Palma
Among venomous animals, Hymenoptera have been suggested as a rich source of natural toxins. Due to their broad ecological diversity, venom from Hymenoptera insects (bees, wasps and ants) have evolved differentially thus widening the types and biological functions of their components. To date, insect toxinology analysis have scarcely uncovered the complex composition of bee, wasp and ant venoms which include low molecular weight compounds, highly abundant peptides and proteins, including several allergens. In Hymenoptera, these complex mixtures of toxins represent a potent arsenal of biological weapons that are used for self-defense, to repel intruders and to capture prey...
April 28, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29675865/allergen-immunotherapy-in-people-dogs-cats-and-horses-differences-similarities-and-research-needs
#5
R S Mueller, E Jensen-Jarolim, F Roth-Walter, E Marti, J Janda, A A Seida, D DeBoer
In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Subcutaneous, epicutaneous, intralymphatic, oral and sublingual protocols of AIT exist. In animals, most data are available in dogs where subcutaneous AIT is an accepted treatment for atopic dermatitis...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29656144/short-and-long-term-management-of-cases-of-venom-induced-anaphylaxis-via-is-suboptimal
#6
Ashley Tritt, Sofianne Gabrielli, Sarah Zahabi, Ann Clarke, Jocelyn Moisan, Harley Eisman, Judy Morris, Lea Restivo, Greg Shand, Moshe Ben-Shoshan
BACKGROUND: Venom induced anaphylaxis (VIA) accounts for severe reactions. However, little is known about the short and long-term management of VIA cases. OBJECTIVE: To assess the short and long-term management of VIA. METHODS: Using a national anaphylaxis registry (C-CARE), we identified VIA cases presenting to EDs in Montreal and to emergency medical services(EMS) in Western Quebec over a four-year period. Data were collected on clinical characteristics, triggers, and management...
April 12, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29629956/what-you-should-not-miss-from-the-systematic-reviews-and-meta-analyses-on-allergen-specific-immunotherapy-in-2017
#7
Désirée Larenas-Linnemann, Jorge A Luna-Pech
PURPOSE OF REVIEW: Allergen immunotherapy (AIT) is a well recognized and extensively studied therapeutic intervention for some allergic diseases. Every year new systematic reviews and meta-analysis provide the most powerful source of evidence to orient decision making on prevention or efficacy of AIT. We here discuss systematic reviews and meta-analyses on AIT (published January 2017 to February 2018). RECENT FINDINGS: We identified 4 systematic reviews and 10 meta-analyses...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29553119/-hymenoptera-venom-and-anaphylaxis-hymenoptera-venom-allergy
#8
Hirokuni Hirata, Yasutsugu Fukushima
No abstract text is available yet for this article.
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29552869/the-skin-prick-test
#9
F Frati, C Incorvaia, C Cavaliere, G Di Cara, F Marcucci, S Esposito, S Masieri
The skin prick test (SPT) is the most common test for the diagnosis of allergy. SPT is performed by pricking the skin, usually in the volar surface of the forearm, with a lancet through a drop of an allergen extract and is usually the first choice test in the diagnostic workup for allergic diseases because of its reliability, safety, convenience and low cost. SPT is minimally invasive and has the advantage of testing multiple allergens in 15 to 20 min. In children, SPT is far less disturbing than venipuncture and is used to obtain a sample of serum to measure specific IgE through in vitro tests...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29532852/inhibitory-effects-of-bee-venom-on-mast-cell-mediated-allergic-inflammatory-responses
#10
Yun-Mi Kang, Kyung-Sook Chung, In-Hoon Kook, Yoon-Bum Kook, Hyunsu Bae, Minho Lee, Hyo-Jin An
Although bee venom (BV) is a toxin that causes bee stings to be painful, it has been widely used clinically for the treatment of certain immune‑associated diseases. BV has been used traditionally for the treatment of chronic inflammatory diseases. In this regard, the present study analyzed the effect of BV on the regulation of inflammatory mediator production by mast cells and their allergic inflammatory responses in an animal model. HMC‑1 cells were treated with BV prior to stimulation with phorbol‑12‑myristate 13‑acetate plus calcium ionophore A23187 (PMACI)...
June 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29518421/mast-cell-activation-test-in-the-diagnosis-of-allergic-disease-and-anaphylaxis
#11
Rajia Bahri, Adnan Custovic, Peter Korosec, Marina Tsoumani, Martin Barron, Jiakai Wu, Rebekah Sayers, Alf Weimann, Monica Ruiz-Garcia, Nandinee Patel, Abigail Robb, Mohamed H Shamji, Sara Fontanella, Mira Silar, E N Clare Mills, Angela Simpson, Paul J Turner, Silvia Bulfone-Paus
BACKGROUND: Food allergy is an increasing public health issue and the most common cause of life-threatening anaphylactic reactions. Conventional allergy tests assess for the presence of allergen-specific IgE, significantly overestimating the rate of true clinical allergy and resulting in overdiagnosis and adverse effect on health-related quality of life. OBJECTIVE: To undertake initial validation and assessment of a novel diagnostic tool, we used the mast cell activation test (MAT)...
March 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29496416/aluminium-al-speciation-in-serum-and-urine-after-subcutaneous-venom-immunotherapy-with-al-as-adjuvant
#12
Bernhard Michalke, Matthias F Kramer, Randolf Brehler
BACKGROUND: Aluminium is associated with disorders and is the commonly used vaccine adjuvant. Understanding the mechanisms of how Al is transported, metabolized or of its toxicity depends on the knowledge of Al-interactions with bioligands, i.e. Al-species. Al-speciation in serum is difficult because of low concentration and the risk of exogenous Al contamination. Furthermore, Al-measurements may be hampered according to various interferences. This study aims for developing quality controlled protocols for reliable Al- and Al-species determination and for investigating probable differences in Al (-speciation) after Al-containing subcutaneous immunotherapy (SIT)...
February 21, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29413342/component-resolved-diagnosis-in-selecting-patients-for-yellowjacket-venom-immunotherapy
#13
Anna Kaarina Kukkonen, Anna Susanna Pelkonen, Sanna Marika Edelman, Paula Maria Kauppi, Mika Juhani Mäkelä
BACKGROUND: Venom immunotherapy is effective in preventing systemic allergic reactions (SARs), but the diagnosis of venom allergy is problematic. OBJECTIVE: To compare the performance of component-resolved diagnosis and conventional tests in patients referred for venom immunotherapy. METHODS: We measured serum-specific immunoglobulin E to yellowjacket and honeybee venoms (Ves v 1 and Ves v 5 and Api m 1), cross-reactive carbohydrate determinants, serum basal tryptase (ImmunoCAP, ThermoFisher Scientific, Uppsala, Sweden), and skin prick test reactions in 84 patients referred to receive venom immunotherapy...
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29413339/current-insights-in-allergen-immunotherapy
#14
REVIEW
Giovanni Passalacqua, Diego Bagnasco, Matteo Ferrando, Enrico Heffler, Francesca Puggioni, Giorgio Walter Canonica
OBJECTIVE: Allergen-specific immunotherapy (AIT) in its subcutaneous and sublingual forms is currently a well-established and experimentally supported treatment for respiratory allergy and hymenoptera venom allergy. There have been advances in its use linked strictly to the advancement in the knowledge of the molecular mechanisms of allergy, the production of well-characterized extracts, and diagnostic techniques. The use of AIT in asthma and the application of new approaches are expanding...
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29399436/current-state-of-follow-up-care-for-patients-with-hymenoptera-venom-anaphylaxis-in-southwest-germany-major-impact-of-early-information
#15
Manisha Manmohan, Sabine Müller, Michèle Myriam Rauber, Frank Koberne, H Reisch, Joachim Koster, Richard Böhm, Martin Messelken, Matthias Fischer, Thilo Jakob
Background: Up to 3.5% of the population experience anaphylactic reactions in response to Hymenoptera stings. Current guidelines are in place for the diagnostic workup and follow-up care of patients with Hymenoptera venom anaphylaxis (HVA). However, little is known about the degree of implementation of the recommendations and patient attitudes toward the recommendations in the general patient population. Methods: For the analysis of the follow-up care in real life, a retrospective questionnaire-based study was conducted in unselected patients who had received treatment from an emergency medical response team for HVA, as documented in records of three regional Medical Emergency Response Centers...
2018: Allergo Journal International
https://www.readbyqxmd.com/read/29375272/a-13-year-real-life-study-on-efficacy-safety-and-biological-effects-of-vespula-venom-immunotherapy
#16
Marcello Albanesi, Andrea Nico, Alessandro Sinisi, Lucia Giliberti, Maria Pia Rossi, Margherita Rossini, Georgios Kourtis, Anna Simona Rucco, Filomena Loconte, Loredana Muolo, Marco Zurlo, Danilo Di Bona, Maria Filomena Caiaffa, Luigi Macchia
Background: Hymenoptera venom immunotherapy (VIT) is a clinically effective treatment. However, little is known about its long-term clinical efficacy and biological effects. Several mechanisms have been proposed to account for VIT efficacy, including reduction of specific IgE and induction of allergen-specific IgG4 , but the overall picture remains elusive. We investigated Vespula VIT clinical efficacy up to 8 years after discontinuation and the kinetics of Vespula -specific IgE and IgG4 ...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29374523/antigen-5-spiked-vespula-and-polistes-venom-extracts-for-vespid-allergy-diagnostics-a-french-multicenter-study
#17
Claude Lambert, Joëlle Birnbaum, Charles Dzviga, Nicolas Hutt, Pol-André Apoil, Françoise Bienvenu, Martine Drouet, Céline Beauvillain, Séverine Brabant, Laurence Guilloux, Delphine Mariotte, François Lavaud, Pascale Nicaise-Roland, Thierry Tabary, Anne Sarrat, Joana Vitte
No abstract text is available yet for this article.
April 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29368278/peptide-and-recombinant-allergen-vaccines-for-food-allergy
#18
REVIEW
Quindelyn S Cook, A Wesley Burks
Food allergy is a significant public health problem, with no suitable treatments available for patients. Currently, patients are limited to avoidance and the use of readily available emergency medications. Immunotherapy is an appealing therapeutic strategy for inducing tolerance. Studies with whole native allergens have demonstrated the efficacy of immunotherapy for food allergy; however, the risk of IgE-mediated reactions with such treatment is significant. Advances in molecular biology techniques, including purification, sequencing, and cloning, have allowed researchers to identify specific allergen components and T cell binding epitopes...
January 24, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29358620/the-high-molecular-weight-dipeptidyl-peptidase-iv-pol-d-3-is-a-major-allergen-of-polistes-dominula-venom
#19
Maximilian Schiener, Christiane Hilger, Bernadette Eberlein, Mariona Pascal, Annette Kuehn, Dominique Revets, Sébastien Planchon, Gunilla Pietsch, Pilar Serrano, Carmen Moreno-Aguilar, Federico de la Roca, Tilo Biedermann, Ulf Darsow, Carsten B Schmidt-Weber, Markus Ollert, Simon Blank
Hymenoptera venom allergy can cause severe anaphylaxis in untreated patients. Polistes dominula is an important elicitor of venom allergy in Southern Europe as well as in the United States. Due to its increased spreading to more moderate climate zones, Polistes venom allergy is likely to gain importance also in these areas. So far, only few allergens of Polistes dominula venom were identified as basis for component-resolved diagnostics. Therefore, this study aimed to broaden the available panel of important Polistes venom allergens...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331065/component-resolved-diagnostics-to-direct-in-venom-immunotherapy-important-steps-towards-precision-medicine
#20
REVIEW
S Blank, M B Bilò, M Ollert
Stings of Hymenoptera can induce IgE-mediated systemic and even fatal allergic reactions. Venom-specific immunotherapy (VIT) is the only disease-modifying and curative treatment of venom allergy. However, choosing the correct venom for VIT represents a necessary prerequisite for efficient protection against further anaphylactic sting reactions after VIT. In the past, therapeutic decisions based on the measurement of specific IgE (sIgE) levels to whole venom extracts were not always straightforward, especially when the patient was not able to identify the culprit insect...
April 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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