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Venom allergy

Kyle Mikals, Douglas Beakes, Taylor A Banks
Hymenoptera venom allergy accounts for approximately 17% of all cases of anaphylaxis. Insect stings are a common occurrence across the world, with significant impact on active duty personnel. Venom immunotherapy (VIT) provides an effective treatment for those with systemic reactions to insect stings and other similar indications. We present a case of severe reaction to hymenoptera venom requiring an epinephrine drip and provide an overview for primary care providers on who should be referred to allergy or an allergist, carry an epinephrine auto-injector, and be a candidate for VIT...
October 2016: Military Medicine
Teresa Stemeseder, Eva Klinglmayr, Stephanie Moser, Lisa Lueftenegger, Roland Lang, Martin Himly, Gertie J Oostingh, Joerg Zumbach, Arne C Bathke, Thomas Hawranek, Gabriele Gadermaier
BACKGROUND: Allergen specific IgE antibodies are a hallmark of type I allergy. The aim of this cross-sectional study was to analyze the sensitization profiles of an Austrian adolescent population utilizing molecule-based IgE diagnosis. METHODS: Serum samples of 501 non-selected pupils from Salzburg, Austria, were tested in ImmunoCAP ISAC(®) for IgE reactivity to 112 single allergens. Sensitization profiles were assessed and statistically coordinated with reported allergies...
October 18, 2016: Allergy
Ami Philipp, Ronald M Ferdman, Jonathan S Tam
No abstract text is available yet for this article.
October 2016: Annals of Allergy, Asthma & Immunology
Joaquín Sastre, Marina Sastre-Ibañez
PURPOSE OF REVIEW: To describe recent insights into how molecular diagnosis can improve indication and selection of suitable allergens for specific immunotherapy and increase the safety of this therapy. RECENT FINDINGS: As specific allergen immunotherapy targets specific allergens, identification of the disease-eliciting allergen is a prerequisite for accurate prescription of treatment. In areas of complex sensitization to aeroallergens or in cases of hymenoptera venom allergy, the use of molecular diagnosis has demonstrated that it may lead to a change in indication and selection of allergens for immunotherapy in a large proportion of patients when compared with diagnosis based on skin prick testing and/or specific IgE determination with commercial extracts...
September 28, 2016: Current Opinion in Allergy and Clinical Immunology
Matteo Ferrando, Diego Bagnasco, Giovanni Passalacqua, Gilda Varricchi, Giorgio Walter Canonica
INTRODUCTION: Since its introduction in clinical practice one century ago for the treatment of respiratory allergic diseases, allergen-specific immunotherapy (AIT) has exhibited a relevant clinical efficacy that was subsequently confirmed in controlled trials. Thus, AIT has been accepted worldwide, as testified by guidelines and international documents. AIT is considered pivotal in the management of allergic rhinitis with or without conjunctivitis and with or without asthma. These conditions, in addition to hymenoptera venom allergy, currently are the accepted indications...
September 19, 2016: Expert Opinion on Biological Therapy
Kai Guan, Li-Sha Li, Jia Yin
BACKGROUND: Venom allergy is significantly underestimated in China. Venom-specific IgE may not provide accurate clinical reactions. Our conducted retrospective analysis observes alternative diagnostic considerations in assessing confirmation and severity of honeybee venom allergy. METHODS: Retrospective review of honeybee venom allergy versus nonallergy patients presented with positive honeybee venom (i1) sIgE results. According to clinically observed reactions caused by a honeybee sting, patients were divided into three groups...
2016: Chinese Medical Journal
Hobart Lee, Sara Halverson, Regina Mackey
Insect bites and stings are common. Risk factors are mostly associated with environmental exposure. Most insect bites and stings result in mild, local, allergic reactions. Large local reactions and systemic reactions like anaphylaxis are possible. Common insects that bite or sting include mosquitoes, ticks, flies, fleas, biting midges, bees, and wasps. The diagnosis is made clinically. Identification of the insect should occur when possible. Management is usually supportive. For anaphylaxis, patients should be given epinephrine and transported to the emergency department for further evaluation...
September 2016: Primary Care
Jan Matysiak, Joanna Matysiak, Anna Bręborowicz, Paweł Dereziński, Zenon J Kokot
INTRODUCTION: Beekeepers are a group of people with high exposure to honeybee stings and with a very high risk of allergy to bee venom. Therefore, they are a proper population to study the correlations between clinical symptoms and results of diagnostic tests. AIM: The primary aim of our study was to assess the correlations between total IgE, venom- and phospholipase A2-specific IgE and clinical symptoms after a bee sting in beekeepers. The secondary aim was to compare the results of diagnostic tests in beekeepers and in individuals with standard exposure to bees...
June 2016: Postȩpy Dermatologii i Alergologii
Theo Gülen, Janne Björkander
Bee and wasp stings can cause allergic reactions. Although the local reactions are more frequent, anaphylaxis due to insect stings can be potentially fatal. Rapid recognition of anaphylaxis is therefore critical and reactions should immediately be treated with i.m. adrenaline. Patients having experienced anaphylaxis should be referred to an allergist for diagnostic evaluation and possible venom-immunotherapy (VIT). The clinical history is essential in diagnosis of venom allergy as the test results are not always reliable...
2016: Läkartidningen
M Schiener, B Eberlein, C Moreno-Aguilar, G Pietsch, P Serrano, M McIntyre, L Schwarze, D Russkamp, T Biedermann, E Spillner, U Darsow, M Ollert, C B Schmidt-Weber, S Blank
BACKGROUND: Hymenoptera stings can cause severe anaphylaxis in untreated venom-allergic patients. A correct diagnosis regarding the relevant species for immunotherapy is often hampered by clinically irrelevant cross-reactivity. In vespid venom allergy, cross-reactivity between venoms of different species can be a diagnostic challenge. To address immunological IgE cross-reactivity on molecular level, seven recombinant antigens 5 of the most important Vespoidea groups were assessed by different diagnostic setups...
August 6, 2016: Allergy
Krzysztof Specjalski, Agnieszka Maciejewska, Ryszard Pawłowski, Marta Chełmińska, Ewa Jassem
BACKGROUND: Allergen-specific immunotherapy is the most effective method of treatment in allergy to wasp venom. However, its mechanism of action is still not fully understood. The aim of this study is to describe changes in microRNA (miRNA) expression in patients undergoing the buildup phase of venom immunotherapy. METHODS: The study group comprised 7 adult patients with a history of severe systemic reactions after stinging by a wasp. In all patients, sensitization to wasp venom had been confirmed by skin tests and serum IgE...
2016: International Archives of Allergy and Immunology
D Gutiérrez Fernández, A Moreno-Ancillo, S Fernández Meléndez, C Domínguez-Noche, P Gálvez Ruiz, T Alfaya Arias
INTRODUCTION: Hymenoptera venom immunotherapy (VIT) is an effective treatment but not one devoid of risk as both local and systemic adverse reactions may occur especially in the initial stages of treatment. We compared the tolerance to three buildup protocols of VIT and analyzed risk factors associated with adverse reactions occurring in this phase. METHODS: We enrolled 165 patients divided into three groups based on the buildup protocol used (3, 4, 9 weeks). Severity of systemic reactions was evaluated according to World Allergy Organization model...
April 19, 2016: Journal of Investigational Allergology & Clinical Immunology
B Ruiz, P Serrano, C Moreno
BACKGROUND: Different clinical behaviours have been identified in patients allergic to bee venom. Compound resolved diagnosis could be appropriated to looking for these differences. Objective: to analyse if sIgE-Api m 4 is able to identify a particular kind of allergy to bee venom, and to describe the response to bee venom immunotherapy (bVIT) of patients. METHODS: Prospective study including 31 patients allergic to bee venom, who were allocated depending on sIgE-Api m4<0...
April 11, 2016: Journal of Investigational Allergology & Clinical Immunology
Marcel Frick, Jörg Fischer, Arthur Helbling, Franziska Ruëff, Dorothea Wieczorek, Markus Ollert, Wolfgang Pfützner, Sabine Müller, Johannes Huss-Marp, Britta Dorn, Tilo Biedermann, Jonas Lidholm, Gerta Ruecker, Frank Bantleon, Michaela Miehe, Edzard Spillner, Thilo Jakob
BACKGROUND: Component resolution recently identified distinct sensitization profiles in honey bee venom (HBV) allergy, some of which were dominated by specific IgE to Api m 3 and/or Api m 10, which have been reported to be underrepresented in therapeutic HBV preparations. OBJECTIVE: We performed a retrospective analysis of component-resolved sensitization profiles in HBV-allergic patients and association with treatment outcome. METHODS: HBV-allergic patients who had undergone controlled honey bee sting challenge after at least 6 months of HBV immunotherapy (n = 115) were included and classified as responder (n = 79) or treatment failure (n = 36) on the basis of absence or presence of systemic allergic reactions upon sting challenge...
May 24, 2016: Journal of Allergy and Clinical Immunology
Lisa Arzt, Danijela Bokanovic, Ines Schwarz, Christoph Schrautzer, Cesare Massone, Michael Horn, Werner Aberer, Gunter Sturm
Stings in the head region are considered to be a risk factor for severe systemic reactions to Hymenoptera stings. We supposed that stings in skin areas, which are well supplied with blood, lead to more severe reactions and tested our hypothesis in 847 patients with confirmed Hymenoptera venom allergy. However, symptom severity was independent from sting site: only 16.3% of patients with severe reactions were stung on the head (p=0.017). But we confirmed age > 40 years (p<0.001) as well as elevated basal tryptase levels (p=0...
June 27, 2016: Allergy
Richele J A Machado, Andréia B Estrela, Ana K L Nascimento, Menilla M A Melo, Manoela Torres-Rêgo, Edeltrurdes O Lima, Hugo A O Rocha, Eneas Carvalho, Arnóbio A Silva-Junior, Matheus F Fernandes-Pedrosa
The presence of bioactive peptides in animal venoms has been targeted in scientific research for assessing biological activities, as well as mechanisms of action. A recent study by our group observed hypotensive action of TistH (Tityus stigmurus Hypotensin), a peptide deduced from the transcriptome of T. stigmurus venom gland. The present study aims to analyze TistH structure properties and to evaluate its toxicity on normal and tumor cells, its in vitro antimicrobial activity, as well as its inflammatory effect...
September 1, 2016: Toxicon: Official Journal of the International Society on Toxinology
Miguel A Sanjuan, Divya Sagar, Roland Kolbeck
There is accumulating evidence to suggest that IgE plays a significant role in autoimmunity. The presence of circulating self-reactive IgE in patients with autoimmune disorders has been long known but, at the same time, largely understudied. However, studies have shown that the increased IgE concentration is not associated with higher prevalence for atopy and allergy in patients with autoimmune diseases, such as systemic lupus erythematosus. IgE-mediated mechanisms are conventionally known to facilitate degranulation of mast cells and basophils and promote TH2 immunity, mechanisms that are not only central to mounting an appropriate defense against parasitic worms, noxious substances, toxins, venoms, and environmental irritants but that also trigger exuberant allergic reactions in patients with allergies...
June 2016: Journal of Allergy and Clinical Immunology
Margitta Worm, Josefine Grünhagen, Sabine Dölle
Anaphylactic reactions due to food occur in the context of food allergy and, together with venom and drugs, are the most frequent elicitors of severe allergic reactions. In small children the most frequent elicitors of severe allergic reactions according to data from the anaphylaxis registry are hen's egg and milk, whereas in school children peanut and hazelnut are frequent elicitors of allergic reactions. Other frequent elicitors of anaphylactic reactions in childhood are wheat and soy. In adults the most frequent elicitors of severe allergic reactions due to food, based on data from the anaphylaxis registry, are wheat, soy, celery, shellfish and hazelnut...
July 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Betül Ayşe Sin, Derya Öztuna, Aslı Gelincik, Feridun Gürlek, Abdullah Baysan, Aytül Zerrin Sin, Ömür Aydın, Zeynep Mısırlıgil
PURPOSE: "Vespid Allergy Quality of Life Questionnaire (VQLQ)" has been used to assess psychological burden of disease. The aim of this study was to evaluate validity, reliability and responsiveness to interventions of the Turkish version. METHODS: The Turkish language Questionnaire (VQLQ-T) was administered to 81 patients with bee allergy and 65 patients with vespid allergy from different groups to achieve cross-sectional validation. To establish longitudinal validity, the questionnaire was administered to 36 patients treated with venom immunotherapy...
2016: SpringerPlus
Patricia Kane Matron, Victoria Timms, Roisin Fitzsimons
Hymenoptera venom allergy is an immunoglobulin E (IgE)-mediated hypersensitivity to the venom of insects from the Hymenoptera order and is a common cause of anaphylaxis. A diagnosis of venom allergy is made by taking an accurate medical, family and social history, alongside specific allergy testing. Systemic reactions to Hymenoptera venom occur in a small proportion of the population; these range from mild to life-threatening in severity. Treatment for local reactions involves the use of cold packs, antihistamines, analgesia and topical corticosteroids to help alleviate swelling, pain and pruritus...
May 25, 2016: Nursing Standard
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