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Venom allergy

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https://www.readbyqxmd.com/read/27914814/rush-venom-immunotherapy-in-children
#1
Ronit Confino-Cohen, Yossi Rosman, Arnon Goldberg
BACKGROUND: Rush venom immunotherapy (VIT) is highly effective in Hymenoptera venom allergy. Still, specific data regarding its safety and efficiency in children are rather sparse. OBJECTIVES: The objective of this study was to better evaluate the safety and efficiency of rush VIT in this specific age group. METHODS: Children younger than 16 years with systemic reaction to insect sting involving, at least, one body system other than skin and children aged 16-18 years with any kind of systemic reaction were offered conventional or rush VIT with a build-up phase that lasted 3 days...
November 30, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27907922/distinct-contributory-factors-determine-basophil-allergen-sensitivity-in-grass-pollen-rhinitis-and-in-anaphylactic-wasp-venom-allergy
#2
Peter Korošec, Mira Šilar, Peter Kopač, Renato Eržen, Mihaela Zidarn, Mitja Košnik
BACKGROUND: We sought to determine whether basophil-allergen sensitivity could be transferred to donor basophils by passive IgE sensitisation in allergic rhinitis and anaphylactic Hymenoptera venom hypersensitivity. METHODS: We studied 15 wasp venom-, 19 grass pollen- and 2 house dust mite-allergic patients, 2 healthy donors, and 8 wasp venom-allergic donors. In all subjects, we first evaluated the initial basophil response to wasp venom, grass pollen, or house dust mite allergen...
December 2, 2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27903075/australian-taipan-oxyuranus-spp-envenoming-clinical-effects-and-potential-benefits-of-early-antivenom-therapy-australian-snakebite-project-asp-25
#3
Christopher I Johnston, Nicole M Ryan, Margaret A O'Leary, Simon G A Brown, Geoffrey K Isbister
CONTEXT: Taipans (Oxyuranus spp.) are medically important venomous snakes from Australia and Papua New Guinea. The objective of this study was to describe taipan envenoming in Australian and its response to antivenom. METHODS: Confirmed taipan bites were recruited from the Australian Snakebite Project. Data were collected prospectively on all snakebites, including patient demographics, bite circumstances, clinical effects, laboratory results, complications and treatment...
November 30, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27826019/molecular-cloning-expression-and-ige-immunoreactivity-of-phospholipase-a1-a-major-allergen-from-polybia-paulista-hymenoptera-vespidae-venom
#4
Amilcar Perez-Riverol, Franco Dani Campos Pereira, Alexis Musacchio Lasa, Luis Gustavo Romani Fernandes, José Roberto Aparecido Dos Santos-Pinto, Débora Lais Justo-Jacomini, Gabriel Oliveira de Azevedo, Murilo Luiz Bazon, Mario Sergio Palma, Ricardo de Lima Zollner, Márcia Regina Brochetto-Braga
Polybia paulista (Hymenoptera: Vespidae) is a clinically relevant social wasp that frequently causes stinging accidents in southeast Brazil. To date, diagnosis and specific immunotherapy (SIT) of allergy are based on the use of crude venom extracts. Production of recombinant forms of major allergens from P. paulista venom will improve diagnosis and SIT of allergic patients by reducing the incidence of cross-reactivity and non-specific sensitization. Here, we describe the molecular cloning, heterologous expression, purification and IgE-mediated immunodetection of phospholipase A1 (Poly p 1), a major allergen from P...
December 15, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27790249/cloning-structural-modelling-and-characterization-of-vest2s-a-wasp-venom-hyaluronidase-haase-from-vespa-tropica
#5
Prapenpuksiri Rungsa, Paroonkorn Incamnoi, Sophida Sukprasert, Nunthawun Uawonggul, Sompong Klaynongsruang, Jureerut Daduang, Rina Patramanon, Sittiruk Roytrakul, Sakda Daduang
BACKGROUND: Wasp venom is a complex mixture containing proteins, enzymes and small molecules, including some of the most dangerous allergens. The greater banded wasp (Vespa tropica) is well-known for its lethal venom, whose one of the major components is a hyaluronidase (HAase). It is believed that the high protein proportion and activity of this enzyme is responsible for the venom potency. METHODS: In the present study, cDNA cloning, sequencing and 3D-structure of Vespa tropica venom HAase were described...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/27788885/comparison-of-systemic-reactions-in-rush-cluster-and-standard-build-aeroallergen-immunotherapy
#6
Andrew W Winslow, Joseph C Turbyville, J Wesley Sublett, James L Sublett, Stephen J Pollard
BACKGROUND: Given the choice of standard, cluster, and rush build-up for aeroallergen immunotherapy, standard-build immunotherapy has generally been preferred because of a perceived high rate of systemic reactions (SRs) associated with cluster and rush immunotherapy. OBJECTIVE: To characterize the incidence of SRs during standard, cluster, and rush build-up immunotherapy in an allergy practice during a 5-year period. METHODS: A retrospective review was conducted among patients receiving standard-build, 8- to 10-step cluster, or 2-day rush immunotherapy from January 1, 2010, through December 31, 2014, at Family Allergy & Asthma clinics in Louisville, Kentucky...
November 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27787580/-insect-venom-allergies-update-2016-for-otorhinolaryngologists
#7
L Klimek, N Dippold, A Sperl
Due to the increasing incidence of hymenoptera venom allergies and the potentially life-threatening reactions, it is important for otolaryngologists working in allergology to have an understanding of modern diagnostic and treatment standards for this allergic disease. Molecular diagnosis with recombinant single allergens from bee and wasp venom components improves the diagnostics of insect venom allergies, particularly in patients with double-positive extract-based test results. Detection of specific sensitizations to bee or wasp venom enables double sensitizations to be better distinguished from cross-reactivity...
December 2016: HNO
https://www.readbyqxmd.com/read/27753590/stinging-the-conscience-a-case-of-severe-hymenoptera-anaphylaxis-and-the-need-for-provider-awareness
#8
Kyle Mikals, Douglas Beakes, Taylor A Banks
Hymenoptera venom allergy accounts for approximately 17% of all cases of anaphylaxis. Insect stings are a common occurrence across the world, with significant impact on active duty personnel. Venom immunotherapy (VIT) provides an effective treatment for those with systemic reactions to insect stings and other similar indications. We present a case of severe reaction to hymenoptera venom requiring an epinephrine drip and provide an overview for primary care providers on who should be referred to allergy or an allergist, carry an epinephrine auto-injector, and be a candidate for VIT...
October 2016: Military Medicine
https://www.readbyqxmd.com/read/27753449/cross-sectional-study-on-allergic-sensitization-of-austrian-adolescents-using-molecule-based-ige-profiling
#9
Teresa Stemeseder, Eva Klinglmayr, Stephanie Moser, Lisa Lueftenegger, Roland Lang, Martin Himly, Gertie J Oostingh, Joerg Zumbach, Arne C Bathke, Thomas Hawranek, Gabriele Gadermaier
BACKGROUND: Allergen specific IgE antibodies are a hallmark of type I allergy. The aim of this cross-sectional study was to analyze the sensitization profiles of an Austrian adolescent population utilizing molecule-based IgE diagnosis. METHODS: Serum samples of 501 non-selected pupils from Salzburg, Austria, were tested in ImmunoCAP ISAC(®) for IgE reactivity to 112 single allergens. Sensitization profiles were assessed and statistically coordinated with reported allergies...
October 18, 2016: Allergy
https://www.readbyqxmd.com/read/27742083/evaluation-of-venom-allergy
#10
Ami Philipp, Ronald M Ferdman, Jonathan S Tam
No abstract text is available yet for this article.
October 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27685663/molecular-diagnosis-and-immunotherapy
#11
Joaquín Sastre, Marina Sastre-Ibañez
PURPOSE OF REVIEW: To describe recent insights into how molecular diagnosis can improve indication and selection of suitable allergens for specific immunotherapy and increase the safety of this therapy. RECENT FINDINGS: As specific allergen immunotherapy targets specific allergens, identification of the disease-eliciting allergen is a prerequisite for accurate prescription of treatment. In areas of complex sensitization to aeroallergens or in cases of hymenoptera venom allergy, the use of molecular diagnosis has demonstrated that it may lead to a change in indication and selection of allergens for immunotherapy in a large proportion of patients when compared with diagnosis based on skin prick testing and/or specific IgE determination with commercial extracts...
December 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27620194/mk-8237-a-house-dust-mite-vaccine-for-treating-allergic-rhinitis-asthma-and-atopic-dermatitis
#12
Matteo Ferrando, Diego Bagnasco, Giovanni Passalacqua, Gilda Varricchi, Giorgio Walter Canonica
INTRODUCTION: Since its introduction in clinical practice one century ago for the treatment of respiratory allergic diseases, allergen-specific immunotherapy (AIT) has exhibited a relevant clinical efficacy that was subsequently confirmed in controlled trials. Thus, AIT has been accepted worldwide, as testified by guidelines and international documents. AIT is considered pivotal in the management of allergic rhinitis with or without conjunctivitis and with or without asthma. These conditions, in addition to hymenoptera venom allergy, currently are the accepted indications...
November 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27569237/use-of-sige-t-ige-in-predicting-systemic-reactions-retrospective-analysis-of-54-honeybee-venom-allergy-cases-in-north-china
#13
Kai Guan, Li-Sha Li, Jia Yin
BACKGROUND: Venom allergy is significantly underestimated in China. Venom-specific IgE may not provide accurate clinical reactions. Our conducted retrospective analysis observes alternative diagnostic considerations in assessing confirmation and severity of honeybee venom allergy. METHODS: Retrospective review of honeybee venom allergy versus nonallergy patients presented with positive honeybee venom (i1) sIgE results. According to clinically observed reactions caused by a honeybee sting, patients were divided into three groups...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27545732/insect-allergy
#14
REVIEW
Hobart Lee, Sara Halverson, Regina Mackey
Insect bites and stings are common. Risk factors are mostly associated with environmental exposure. Most insect bites and stings result in mild, local, allergic reactions. Large local reactions and systemic reactions like anaphylaxis are possible. Common insects that bite or sting include mosquitoes, ticks, flies, fleas, biting midges, bees, and wasps. The diagnosis is made clinically. Identification of the insect should occur when possible. Management is usually supportive. For anaphylaxis, patients should be given epinephrine and transported to the emergency department for further evaluation...
September 2016: Primary Care
https://www.readbyqxmd.com/read/27512356/the-correlation-between-anti-phospholipase-a2-specific-ige-and-clinical-symptoms-after-a-bee-sting-in-beekeepers
#15
Jan Matysiak, Joanna Matysiak, Anna Bręborowicz, Paweł Dereziński, Zenon J Kokot
INTRODUCTION: Beekeepers are a group of people with high exposure to honeybee stings and with a very high risk of allergy to bee venom. Therefore, they are a proper population to study the correlations between clinical symptoms and results of diagnostic tests. AIM: The primary aim of our study was to assess the correlations between total IgE, venom- and phospholipase A2-specific IgE and clinical symptoms after a bee sting in beekeepers. The secondary aim was to compare the results of diagnostic tests in beekeepers and in individuals with standard exposure to bees...
June 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27505851/-not-available
#16
Theo Gülen, Janne Björkander
Bee and wasp stings can cause allergic reactions. Although the local reactions are more frequent, anaphylaxis due to insect stings can be potentially fatal. Rapid recognition of anaphylaxis is therefore critical and reactions should immediately be treated with i.m. adrenaline. Patients having experienced anaphylaxis should be referred to an allergist for diagnostic evaluation and possible venom-immunotherapy (VIT). The clinical history is essential in diagnosis of venom allergy as the test results are not always reliable...
2016: Läkartidningen
https://www.readbyqxmd.com/read/27496543/application-of-recombinant-antigen-5-allergens-from-seven-allergy-relevant-hymenoptera-species-in-diagnostics
#17
M Schiener, B Eberlein, C Moreno-Aguilar, G Pietsch, P Serrano, M McIntyre, L Schwarze, D Russkamp, T Biedermann, E Spillner, U Darsow, M Ollert, C B Schmidt-Weber, S Blank
BACKGROUND: Hymenoptera stings can cause severe anaphylaxis in untreated venom-allergic patients. A correct diagnosis regarding the relevant species for immunotherapy is often hampered by clinically irrelevant cross-reactivity. In vespid venom allergy, cross-reactivity between venoms of different species can be a diagnostic challenge. To address immunological IgE cross-reactivity on molecular level, seven recombinant antigens 5 of the most important Vespoidea groups were assessed by different diagnostic setups...
August 6, 2016: Allergy
https://www.readbyqxmd.com/read/27441833/changes-in-the-expression-of-microrna-in-the-buildup-phase-of-wasp-venom-immunotherapy-a-pilot-study
#18
Krzysztof Specjalski, Agnieszka Maciejewska, Ryszard Pawłowski, Marta Chełmińska, Ewa Jassem
BACKGROUND: Allergen-specific immunotherapy is the most effective method of treatment in allergy to wasp venom. However, its mechanism of action is still not fully understood. The aim of this study is to describe changes in microRNA (miRNA) expression in patients undergoing the buildup phase of venom immunotherapy. METHODS: The study group comprised 7 adult patients with a history of severe systemic reactions after stinging by a wasp. In all patients, sensitization to wasp venom had been confirmed by skin tests and serum IgE...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27374925/analysis-of-the-safety-and-tolerance-of-three-buildup-protocols-of-insect-venom-immunotherapy-frequently-used-in-spain
#19
D Gutiérrez Fernández, A Moreno-Ancillo, S Fernández Meléndez, C Domínguez-Noche, P Gálvez Ruiz, T Alfaya Arias
INTRODUCTION: Hymenoptera venom immunotherapy (VIT) is an effective treatment but not one devoid of risk as both local and systemic adverse reactions may occur especially in the initial stages of treatment. We compared the tolerance to three buildup protocols of VIT and analyzed risk factors associated with adverse reactions occurring in this phase. METHODS: We enrolled 165 patients divided into three groups based on the buildup protocol used (3, 4, 9 weeks). Severity of systemic reactions was evaluated according to World Allergy Organization model...
April 19, 2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27374382/ige-api-m4-is-useful-to-identify-a-particular-phenotype-of-allergy-to-bee-venom
#20
B Ruiz, P Serrano, C Moreno
BACKGROUND: Different clinical behaviours have been identified in patients allergic to bee venom. Compound resolved diagnosis could be appropriated to looking for these differences. Objective: to analyse if sIgE-Api m 4 is able to identify a particular kind of allergy to bee venom, and to describe the response to bee venom immunotherapy (bVIT) of patients. METHODS: Prospective study including 31 patients allergic to bee venom, who were allocated depending on sIgE-Api m4<0...
April 11, 2016: Journal of Investigational Allergology & Clinical Immunology
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