Hao Wu, Zhao-Xing Li, Kang Fang, Zi-Ying Zhao, Ming-Chuang Sun, An-Qi Feng, Zhu-Yun Leng, Ze-Hua Zhang, Yuan Chu, Li Zhang, Tao Chen, Mei-Dong Xu
Substantial evidence attests to the pivotal role of cancer stem cells (CSC) in both tumorigenesis and drug resistance. A member of the forkhead box (FOX) family, FOXC1, assumes significance in embryonic development and organogenesis. Furthermore, FOXC1 functions as an overexpressed transcription factor in various tumors, fostering proliferation, enhancing migratory capabilities, and promoting drug resistance, while maintaining stem-cell-like properties. Despite these implications, scant attention has been devoted to its role in esophageal squamous cell carcinoma...
February 27, 2024: Cell Death Discovery