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Intrahepatic cholangiocarcinoma

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https://www.readbyqxmd.com/read/29147441/intrahepatic-biliary-metastasis-of-colonic-adenocarcinoma-a-case-report-with-immunohistochemical-analysis
#1
Keisuke Kawashima, Naoki Watanabe, Sho Tawada, Takahito Adachi, Makoto Yamada, Yusuke Kitoh, Tamotsu Takeuchi, Takuji Tanaka
Although intrabiliary metastasis of carcinoma in the liver is unusual, intraductal and/or intraepithelial spread of cancer cells along intrahepatic bile ducts is now well recognized as hepatic metastasis. However, several clinical and laboratory findings, including images, lead us to differentially diagnose from primary intrahepatic cholangiocarcinoma. We report here on a case of colonic adenocarcinoma that metastasized to the liver with spread along with the intrahepatic bile duct of S5/6 area. The patient was a 51-year-old man and clinically diagnosed liver metastasis of sigmoid colon cancer (tub2, pMP, ly1, v0, n0), which was diagnosed and treated by sigmoidectomy 7 years ago...
June 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29144005/multicentre-study-of-the-impact-of-morbidity-on-long-term-survival-following-hepatectomy-for-intrahepatic-cholangiocarcinoma
#2
(no author information available yet)
No abstract text is available yet for this article.
December 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29142898/intrinsic-and-environmental-factors-in-intrahepatic-cholangiocarcinoma-development
#3
EDITORIAL
Detian Yuan, María García-Beccaria, Mathias Heikenwalder
No abstract text is available yet for this article.
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29138576/progression-free-survival-of-up-to-8-months-of-an-advanced-intrahepatic-cholangiocarcinoma-patient-treated-with-apatinib-a-case-report
#4
Fu-Chao Ma, Qian Yu, Zhi-Ming Zeng, Rong-Quan He, Chao-Hua Mo, Jin-Cai Zhong, Jie Ma, Zhen-Bo Feng, Gang Chen, Xiao-Hua Hu
Intrahepatic cholangiocarcinoma (ICC) arises from the biliary epithelium and is a relatively rare and highly fatal neoplasm. The prognosis is poor, and survival is limited to a few months. Here, we report a case of advanced ICC that was successfully treated with apatinib, a new oral tyrosine kinase inhibitor that targets the intracellular domain of vascular endothelial growth factor receptor-2. To the best of our knowledge, this is the first case report of the successful use of apatinib for advanced ICC; this treatment has demonstrated fewer toxic effects than traditional cytotoxic chemotherapy...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29137600/perioperative-blood-transfusion-does-not-affect-recurrence-free-and-overall-survivals-after-curative-resection-for-intrahepatic-cholangiocarcinoma-a-propensity-score-matching-analysis
#5
Pei-Yun Zhou, Zheng Tang, Wei-Ren Liu, Meng-Xin Tian, Lei Jin, Xi-Fei Jiang, Han Wang, Chen-Yang Tao, Zhen-Bin Ding, Yuan-Fei Peng, Shuang-Jian Qiu, Zhi Dai, Jian Zhou, Jia Fan, Ying-Hong Shi
BACKGROUND: Whether perioperative blood transfusions (PBTs) adversely influence oncological outcomes for intrahepatic cholangiocarcinoma (ICC) patients after curative resection remains undetermined. METHODS: Of the 605 patients who underwent curative liver resection for ICC between 2000 and 2012, 93 received PBT. We conducted Cox regression and variable selection logistic regression analyses to identify confounding factors of PBT. Propensity score matching (PSM) and Cox regression analyses were used to compare the overall survival (OS) and disease-free survival (DFS) between the patients with or without PBT...
November 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29137375/impact-of-tumor-size-and-cirrhotic-background-for-differentiating-hcc-and-icc-with-ceus-does-it-matter-for-patients-undergoing-hepatectomy
#6
Chen Jin, Xiao-Yun Zhang, Jia-Wu Li, Chuan Li, Wei Peng, Tian-Fu Wen, Yan Luo, Qiang Lu, Xiao-Fei Zhong, Jing-Yi Zhang, Lv-Nan Yan, Jia-Yin Yang
Objectives: The aim of this study was to investigate the role of contrast-enhanced ultrasound (CEUS) in differentiating hepatocellular carcinoma (HCC) vs. intrahepatic cholangiocarcinoma (ICC) and primary liver cancer vs. benign liver lesions for surgical decision making. Methods: Data from 328 patients (296 primary liver cancer patients: 232 HCC and 64 ICC patients and 32 benign hepatic lesion patients) who underwent hepatectomy at our center were retrospectively collected from 2010 to 2015...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135100/safety-and-efficacy-of-liver-resections-in-elderly-patients
#7
Georgios C Sotiropoulos, Ioannis D Kostakis, Nikolaos Machairas, Stylianos Kykalos, Gregory Kouraklis
PURPOSE: Elderly patients constitute a special group of surgical candidates due to the frequent coexistence of major comorbidities. We report our experience in performing liver resections in patients aged 75 years or older. METHODS: During a period of 62 months, 154 patients underwent liver resections, out of which 20 were 75 years old or older. Our prospectively maintained database was reviewed regarding patient and tumor characteristics, intraoperative and postoperative data...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29133597/occupational-exposure-to-asbestos-and-risk-of-cholangiocarcinoma-a-population-based-case-control-study-in-four-nordic-countries
#8
Andrea Farioli, Kurt Straif, Giovanni Brandi, Stefania Curti, Kristina Kjaerheim, Jan Ivar Martinsen, Pär Sparen, Laufey Tryggvadottir, Elisabete Weiderpass, Guido Biasco, Francesco Saverio Violante, Stefano Mattioli, Eero Pukkala
OBJECTIVES: To assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC). METHODS: We conducted a case-control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurring among subjects born in 1920 or later in Finland, Iceland, Norway and Sweden. Each case was individually matched by birth year, gender and country to five population controls...
November 13, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29130106/molecular-alterations-of-the-nf2-gene-in-hepatocellular-carcinoma-and-intrahepatic-cholangiocarcinoma
#9
Ning Zhang, Zhang Zhao, Jiang Long, Hai Li, Bei Zhang, Guangyong Chen, Xiaojin Li, Tingxia Lv, Wei Zhang, Xiaojuan Ou, Anjian Xu, Jian Huang
Neurofibromatosis type 2 with mutations in the neurofibromin 2 (NF2) gene, encoding the Merlin protein, is an autosomal dominant disorder characterized by enhanced cancer predisposition, particularly tumors of the central nervous system. Recent animal studies indicate that disruption of NF2/Merlin function in oval cells, which are hepatic progenitor cells, may lead to the development of primary liver cancers including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC); however, its role in human primary liver cancer remains unclear...
December 2017: Oncology Reports
https://www.readbyqxmd.com/read/29122566/mutations-of-candidate-tumor-suppressor-genes-at-chromosome-3p-in-intrahepatic-cholangiocarcinoma
#10
Huey-Ling You, Wan-Ting Huang, Ting-Ting Liu, Shao-Wen Weng, Hock-Liew Eng
The genetic status of candidate tumor suppressor genes (TSGs) at chromosome 3p has not yet been elucidated in intrahepatic cholangiocarcinoma (iCCA). Herein, we retrospectively investigated 32 fresh iCCA case samples from a single medical institution to clarify mutations of 11 TSGs by next-generation sequencing. Validation of the mutations was performed on the MassARRAY platform or by high-resolution melting curve analysis. We then integrated the gene mutations into copy number alterations at chromosome 3p that had been generated in a previous study using the same fresh iCCA samples, and correlated the integration results with the clinicopathologic features...
November 7, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29119290/a-proposed-severity-classification-system-for-hepatolithiasis-based-on-an-analysis-of-prognostic-factors-in-a-japanese-patient-cohort
#11
Yutaka Suzuki, Toshiyuki Mori, Masaaki Yokoyama, Sangchul Kim, Hirokazu Momose, Ryota Matsuki, Masaharu Kogure, Nobutsugu Abe, Hiroyuki Isayama, Takahiro Nakazawa, Kenji Notohara, Atsushi Tanaka, Toshio Tsuyuguchi, Susumu Tazuma, Hajime Takikawa, Masanori Sugiyama
BACKGROUND: Hepatolithiasis frequently results in severe complications. We conducted a cohort study to identify prognostic factors and to establish a hepatolithiasis severity classification system. METHODS: The study cohort comprised 396 patients who were identified through a 1998 nationwide survey and followed up for 18 years or until death. Cox regression analysis was used to identify prognostic factors. RESULTS: Median survival time of the patients was 308 (range 0-462) months...
November 8, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29113399/dck-expression-a-potential-predictive-biomarker-in-the-adjuvant-gemcitabine-chemotherapy-for-biliary-tract-cancer-after-surgical-resection-results-from-a-phase-ii-study
#12
Sang Myung Woo, Kyong-Ah Yoon, Eun Kyung Hong, Weon Seo Park, Sung-Sik Han, Sang-Jae Park, Jungnam Joo, Eun Young Park, Ju Hee Lee, Yun-Hee Kim, Tae Hyun Kim, Woo Jin Lee
The role of adjuvant therapy following resection of biliary tract cancer (BTC) remains unclear. We therefore evaluated the feasibility and toxicity of adjuvant gemcitabine in patients with BTC. This clinical phase II trial was an open-label, single center, single-arm study. Within 8 weeks after gross complete resection of BTC, patients were started on intravenous infusions of gemcitabine 1000 mg/m(2) over 30 min on days 1, 8, and 15 of every 28-day cycle. Intratumoral expression of cytidine deaminase (CDA), human equilibrative transporter-1 (hENT1), deoxycytidine kinase (dCK) and ribonucleotide reductase subunit 1 (RRM1) was measured by immunohistochemistry...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29110943/differentiation-between-hepatic-alveolar-echinococcosis-and-primary-hepatic-malignancy-with-diffusion-weighted-magnetic-resonance-imaging
#13
R Sade, M Kantarci, H Ogul, B Gundogdu, B Aydınlı
PURPOSE: To determine the value of diffusion-weighted magnetic resonance imaging (DW-MRI) in discriminating between hepatic alveolar echinococcosis (AE) and hepatocellular carcinoma and intrahepatic cholangiocarcinoma. METHODS: We included 49 patients (27 men, 22 women; mean age: 52.02±9.76 [SD] years; range: 25-72years) with 57 histopathologically confirmed hepatic AE lesions. Fifty patients (18 men, 32 women; mean age: 58.93±8.42 [SD] years; range: 42-71years) with 61 histopathologically confirmed hepatocellular carcinoma and 50 patients (24 men, 26 women; mean age: 50...
October 27, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29110582/establishment-of-cholangiocarcinoma-cell-lines-from-patients-in-the-endemic-area-of-liver-fluke-infection-in-thailand
#14
Sunitta Saensa-Ard, Saman Leuangwattanawanit, Laddawan Senggunprai, Nisana Namwat, Sarinya Kongpetch, Yaovalux Chamgramol, Watcharin Loilome, Walaiporn Khansaard, Apinya Jusakul, Auemduan Prawan, Chawalit Pairojkul, Narong Khantikeo, Puangrat Yongvanit, Veerapol Kukongviriyapan
Cholangiocarcinoma is a rare type of cancer which is an increasingly discernible health threat. The disease is usually very difficult in diagnosis and various treatment modalities are typically not effective. Cholangiocarcinoma is a complex and very heterogeneous malignancy characterized by tumor location, different risk factors, molecular profiling, and prognosis. Cancer cell lines represent an important tool for investigation in various aspects of tumor biology and molecular therapeutics. We established two cell lines, KKU-452 and KKU-023, which were derived from patients residing in the endemic area of liver fluke infection in Thailand...
November 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29107934/the-clinical-significance-and-biological-function-of-interferon-regulatory-factor-1-in-cholangiocarcinoma
#15
Peiqi Wan, Junhong Zhang, Qiang Du, David A Geller
Interferon regulatory factor 1 (IRF1) has been suggested to act as a tumor suppressor in human cancers. However, the clinical significance and biological function of IRF1 in cholangiocarcinoma is poorly understood. In our results, IRF1 mRNA and protein expressions were decreased in cholangiocarcinoma tissues and cell lines compared with paired normal hepatic tissues and intrahepatic bile duct epithelial cell line. IRF1 protein low-expression was associated with tumor stage, tumor size, vascular invasion and metastasis and served as a poor independent prognostic parameter in cholangiocarcinoma patients...
November 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29104490/transarterial-chemoembolization-a-favorable-postoperative-management-to-improve-prognosis-of-hepatitis-b-virus-associated-intrahepatic-cholangiocarcinoma-after-surgical-resection
#16
Seogsong Jeong, Bo Zheng, Jian Wang, Jiachang Chi, Ying Tong, Lei Xia, Ning Xu, Jianjun Zhang, Xiaoni Kong, Jinyang Gu, Qiang Xia
Background: There is no information regarding transarterial chemoembolization (TACE) as a postoperative management after hepatic resection for patients with hepatitis B virus (HBV)-associated intrahepatic cholangiocarcinoma (ICC). Methods: Forty-two patients with pathological confirmation of HBV-associated ICC were enrolled. Prognostic impact of the clinicopathological factors as well as postoperative TACE were evaluated. Computed tomography findings of HBV-associated ICC were assessed. Results: Tumor size of larger than 5 cm (hazard ratio [HR], 5...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29096345/hepatopancreatoduodenectomy-for-perihilar-cholangiocarcinoma-following-laparoscopic-total-gastrectomy
#17
Naokazu Chiba, Takahiro Gunji, Yosuke Ozawa, Kosuke Hikita, Toru Sano, Koichi Tomita, Yuta Abe, Shigeyuki Kawachi
INTRODUCTION: Surgical resection is the only curative treatment for perihilar cholangiocarcinoma. However, Hepatopancreatoduodenectomy (HPD) procedure remains controversial in regard to the balance between the survival benefit and high risk of mortality and morbidity. PRESENTATION OF CASE: A 72-year-old man who was revealed the dilation of intrahepatic hepatic duct by computed tomography after laparoscopic total gastrectomy was referred to our hospital. The patient had undergone laparoscopic total gastrectomy with Roux-en-Y esophageal-jejunostomy reconstruction 1year previously...
October 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29095255/both-plasma-and-tumor-tissue-mir-146a-high-expression-correlates-with-prolonged-overall-survival-of-surgical-patients-with-intrahepatic-cholangiocarcinoma
#18
Ri-Xin Zhang, Zhi Zheng, Kai Li, Xin-Hua Wu, Ling Zhu
The purpose of this study was to investigate the association of tumor tissue and plasma miR-146a/b expressions with the clinicopathological properties and overall survival (OS) in surgical patients with intrahepatic cholangiocarcinomas (ICC).Eighty-seven patients with ICC were enrolled. Tumor tissue and plasma sample were collected and miR-146a/b expressions were assessed by quantitative polymerase chain reaction (qPCR). The median follow-up duration was 31 months, and the last follow-up date was January 2017...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29089545/activation-of-fas-fasl-pathway-and-the-role-of-c-flip-in-primary-culture-of-human-cholangiocarcinoma-cells
#19
Gianluca Carnevale, Guido Carpino, Vincenzo Cardinale, Alessandra Pisciotta, Massimo Riccio, Laura Bertoni, Lara Gibellini, Sara De Biasi, Lorenzo Nevi, Daniele Costantini, Diletta Overi, Andrea Cossarizza, Anto de Pol, Eugenio Gaudio, Domenico Alvaro
Intrahepatic cholangiocarcinoma (iCCA) represents a heterogeneous group of malignancies emerging from the biliary tree, often in the context of chronic bile ducts inflammation. The immunological features of iCCA cells and their capability to control the lymphocytes response have not yet been investigated. The aims of the present study were to evaluate the interaction between iCCA cells and human peripheral blood mononuclear cells (PBMCs) and the role of Fas/FasL in modulating T-cells and NK-cells response after direct co-culture...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29081157/-correlation-between-tnm-staging-of-primary-cholangiocarcinoma-and-the-maximum-standard-uptake-value-of-18-f-2-deoxy-d-glucose-positron-emission-tomography-with-computerized-tomography
#20
Z F Wang, X L Lan, Y R Xiao, J P Liu, J S Ji
Objective: To investigate the correlation between TNM staging of primary cholangiocarcinoma and the maximum standard uptake value (SUVmax) of (18)F-2-deoxy-D-glucose positron emission tomography with computerized tomography ((18)F-FDG PET/CT). Methods: A retrospective analysis of 36 patients with confirmed primary cholangiocarcinoma from October 2014 to July 2016 was carried out. All the patients underwent preoperative PET/CT in the Fifth Affiliated Hospital of Wenzhou Medical University from November 2014 to July 2016, the SUVmax was calculated by drawing region of interest around the primitive tumor area...
October 24, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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