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Intrahepatic cholangiocarcinoma

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https://www.readbyqxmd.com/read/29781738/diagnosis-of-cholangiocarcinoma-in-primary-sclerosing-cholangitis
#1
Seyed Alireza Taghavi, Ahad Eshraghian, Ramin Niknam, Gholam Reza Sivandzadeh, Kamran Bagheri Lankarani
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of the hepatobiliary system characterized by chronic inflammation, progressive fibrosis, stricture formation and destruction of extrahepatic and intrahepatic bile ducts. Areas covered: The increased incidence of cholangiocarcinoma (CCA) in PSC has been well documented and can be explained by the continuous inflammation in the biliary tree leading to an enhanced dysplasia-carcinoma sequence. Although PSC patients may progress to liver cirrhosis; CCA most commonly occurs between the ages of 30 and 45 years when cirrhosis has not yet developed...
May 21, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29779308/-current-status-of-laparoscopic-techniques-in-the-surgical-treatment-of-biliary-carcinoma
#2
J D Li, Z L Zhao
Biliary carcinoma includes intrahepatic cholangiocarcinoma, hilar cholangiocarcinoma, distal cholangiocarcinoma, and gallbladder cancer. There are few studies about laparoscopic treatment for biliary malignancy due to the complicated dissection of porta hepatic structure, and even reconstruction of biliary tract and(or) vessel under laparoscopy, which increases the difficulty of the laparoscopic radical resection of biliary malignancy. To promote the standardized application and development of laparoscopic techniques in operation of biliary malignancy, the safety and effectiveness of laparoscopic techniques are explained in this paper...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29779307/-application-of-perihilar-surgical-techniques-in-perihilar-biliary-tract-tumours
#3
J Wang
Perihilar biliary tract tumours include hilar cholangiocarcinoma, gallbladder cancer invading the hepatic hilum and intrahepatic cholangiocarcioma invading the hepatic hilum.The tumours have the special characteristics such as strong invasion capability, the anatomic variant, the pathophysiological complexity, the biological behavior diversity and the difficulty of preoperative evaluation which result in low R0 resection rate, more postoperative complications, more mortality and poor prognosis.The perihilar surgical techniques system aims to set a reasonable and individual operation procedure on the principle of precision surgery by taking the key technique of hilar dissection and exposing, evaluting the hilar anatomy by the means of three-dimensional digital medical image evaluation system, evaluting the relationship between the tumour and hepatic artery and portal vein under the condition of hepatic hilum complete exposure by combining anterograde and retrograde route from intra and extra-hepatic direction to hepatic hilum...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29779306/-surgical-and-comprehensive-treatment-for-intrahepatic-cholangiocarcinoma-patients-from-the-perspective-of-tumor-heterogeneity
#4
Z H Tang, Z W Quan
Intrahepatic cholangiocarcinoma(ICC) is generally found late along with extremely poor prognosis and lack of effective and standardized treatment. Tremendous heterogeneities exist in onset factors, geographic distribution, clinical manifestation, and biological characteristics of ICC patients. However, the relevant causes and mechanisms have not been clearly illustrated. Recent studies indicate that the diverse celluar origins of ICC, including liver cells, bile duct epithelial cells, glandular cells around the duct, and liver stem cells, etc...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29778232/nuclear-bap1-loss-is-common-in-intrahepatic-cholangiocarcinoma-and-a-subtype-of-hepatocellular-carcinoma-but-rare-in-pancreatic-ductal-adenocarcinoma
#5
Asmaa Mosbeh, Khalil Halfawy, Wael S Abdel-Mageed, Dina Sweed, Mohamed H Abdel Rahman
Deletion in the 3p21 region, the chromosomal location of BAP1, has been reported in a subset of hepatocellular carcinoma (HCC), biliary and pancreatic cancers. This suggests that BAP1 could play a role in the pathogenesis of these tumors. We assessed the frequency of BAP1 loss by immunohistochemistry in 103 hepatic, biliary and pancreatic cancers. We also assessed chromosomal alterations in the BAP1 region in the same tumors by genotyping. We identified high frequency 4/8 (50%) of BAP1 loss in intrahepatic cholangicarcinoma (ICC)...
August 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29774134/an-undifferentiated-carcinoma-at-klatskin-position-with-long-term-complete-remission-after-chemotherapy
#6
Bruno Christian Köhler, Benjamin Goeppert, Nina Waldburger, Kai Schlamp, Peter Sauer, Dirk Jäger, Karl Heinz Weiss, Stephan Macher-Göppinger, Henning Schulze-Bergkamen, Peter Schirmacher, Christoph Springfeld
Background: Neoplasms anatomically adjacent to the bile duct usually derive from malignantly transformed cholangiocytes forming cholangiocarcinoma (CCA). CCAs are divided in extrahepatic (eCCA) and intrahepatic (iCCA) tumors. Patients with irresectable CCAs are treated with systemic chemotherapy and have an unfavorable prognosis with a median survival of about one year. Here, we report a case of an undifferentiated carcinoma in Klatskin-position with long-term remission after systemic chemotherapy...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29767442/hepatobiliary-and-pancreatic-intrahepatic-cholangiocarcinoma-with-distant-cutaneous-metastases-to-the-face
#7
M K Kang, E J Goo, S B Kim, K H Kim, T N Kim
No abstract text is available yet for this article.
May 16, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29761164/periostin-and-mesothelin-potential-predictors-of-malignant-progression-in-intrahepatic-cholangiocarcinoma
#8
EDITORIAL
Pranoti Mandrekar, Vincenzo Cardinale
No abstract text is available yet for this article.
May 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29761148/mortality-associated-with-hepatobiliary-disease-in-portugal-between-2006-and-2012
#9
Manuel Coelho da Rocha, Rui T Marinho, Teresa Rodrigues
Introduction: Hepatobiliary disease is becoming a major public health problem, and recent data suggest that the burden of liver disease is higher than previously thought. Our aim was to quantify the mortality from hepatobiliary disease in Portugal and to compare this with the mortality related o other causes over a 7-year period (2006-2012). Materials and Methods: A statistical analysis of mortality data according to cause, sex, age, and region from the National Statistics Institute in Portugal was carried out...
April 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29759640/enhancer-of-zeste-homolog-2-ezh2-regulates-tumor-angiogenesis-and-predicts-recurrence-and-prognosis-of-intrahepatic-cholangiocarcinoma
#10
Shigeki Nakagawa, Hirohisa Okabe, Mayuko Ouchi, Ryuma Tokunaga, Naoki Umezaki, Takaaki Higashi, Takatoshi Kaida, Kota Arima, Yuki Kitano, Hideyuki Kuroki, Kosuke Mima, Hidetoshi Nitta, Katsunori Imai, Daisuke Hashimoto, Yo-Ichi Yamashita, Akira Chikamoto, Hideo Baba
BACKGROUND: Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) and regulates tumor malignancy by gene silencing via histone methylation. In this study we investigate the role of EZH2 in angiogenesis of intrahepatic cholangiocarcinoma (ICC). METHODS: The influence of EZH2 on tumor angiogenesis was examined by bioinformatics analysis of a public database. We also assessed the correlation between EZH2 and vasohibin 1 (VASH1) expression in 47 patients with ICC by immunohistochemical (IHC) staining and in vitro gene silencing assays...
May 11, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29755690/prognostic-value-of-line-1-methylation-level-in-321-patients-with-primary-liver-cancer-including-hepatocellular-carcinoma-and-intrahepatic-cholangiocarcinoma
#11
Tatsunori Miyata, Yo-Ichi Yamashita, Yoshifumi Baba, Kazuto Harada, Takanobu Yamao, Naoki Umezaki, Masayo Tsukamoto, Yuki Kitano, Kensuke Yamamura, Kota Arima, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Mototsugu Shimokawa, Hideo Baba
Background: The methylation level of long interspersed nucleotide element-1 (LINE-1) is a good surrogate marker of the global DNA methylation level. The relationship between LINE-1 methylation level and prognosis in primary liver cancer (PLC) patients remains unclear. Results: LINE-1 methylation levels were significantly lower in HCC and cHCC-CC tissues, but not in ICC tissues, than those in noncancerous liver parenchyma (HCC: p < 0.0001; cHCC-CC: p < 0.001; and ICC: p = 0...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29751883/cholangiocarcinoma
#12
REVIEW
Alyssa M Krasinskas
This article focuses on cholangiocarcinoma, both intrahepatic and extrahepatic. The various classification schemes based on anatomic location, macroscopic growth pattern, microscopic features, and cell of origin are outlined. The clinicopathologic, immunohistochemical and molecular differences between intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma, as well as differences in the 2 subtypes of intrahepatic cholangiocarcinoma, are discussed. Finally, precursor lesions, prognosis, treatment, and promising new potential targeted therapies are reviewed...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29751880/update-on-ancillary-testing-in-the-evaluation-of-high-grade-liver-tumors
#13
REVIEW
Anne Koehne de Gonzalez, Stephen M Lagana
Tissue diagnosis is the gold standard for mass lesions of the liver, but needle core biopsies may sometimes prove challenging. Presented here is a review of a panel of immunohistochemical stains, including hepatocyte in paraffin 1, arginase-1, polyclonal carcinoembryonic antigen, CD10, bile salt export pump, glypican-3, as well as in situ hybridization for albumin RNA, to establish hepatocellular origin in cases in which hepatocellular carcinoma is suspected but the sample is limited or the morphology is challenging, as it may be with cases of scirrhous, fibrolamellar carcinoma, intrahepatic cholangiocarcinoma, and combined hepatocellular-cholangiocarcinoma...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29749456/role-of-the-overexpression-of-traf4-in-predictingthe-prognosis-of-intrahepatic-cholangiocarcinoma
#14
Qiang Kang, Hao Zou, Lei Zhou, Li-Xin Liu, Jia-Bin Cai, Nan Xie, Wei-Hao Li, Chao Zhang, Wan-Hong Shi, Lian-Min Wang, Wei-Han Zhang, Hong Zhu, Shu-Fen Wang, Xiao-Wen Zhang
The incidence of intrahepatic cholangiocarcinoma (ICC) is progressively increasing worldwide, and its prognosis remains poor. Accumulating evidence has demonstrated that tumor necrosis factor receptor-associated factor 4 (TRAF4), an adaptor protein, is involved in the carcinogenesis and progression of several tumor types. However, the function of TRAF4 in predicting prognosis, and mediating migration and invasion of ICC remains to be elucidated. In the present study, immunohistochemistry, western blotting and reverse transcription-quantitative polymerase chain reaction assays were used to determine that the expression of TRAF4 at the mRNA and protein levels in ICC tissues was significantly higher compared with that in non‑tumor tissues...
April 26, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29747443/microsatellite-instability-occurs-rarely-in-patients-with-cholangiocarcinoma-a-retrospective-study-from-a-german-tertiary-care-hospital
#15
Ria Winkelmann, Markus Schneider, Sylvia Hartmann, Andreas A Schnitzbauer, Stefan Zeuzem, Jan Peveling-Oberhag, Martin Leo Hansmann, Dirk Walter
Immune-modulating therapy is a promising therapy for patients with cholangiocarcinoma (CCA). Microsatellite instability (MSI) might be a favorable predictor for treatment response, but comprehensive data on the prevalence of MSI in CCA are missing. The aim of the current study was to determine the prevalence of MSI in a German tertiary care hospital. Formalin-fixed paraffin-embedded tissue samples, obtained in the study period from 2007 to 2015 from patients with CCA undergoing surgical resection with curative intention at Johann Wolfgang Goethe University hospital, were examined...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29746696/detection-of-albumin-expression-by-rna-in-situ-hybridization-is-a-sensitive-and-specific-method-for-identification-of-hepatocellular-carcinomas-and-intrahepatic-cholangiocarcinomas
#16
Fan Lin, Jianhui Shi, Hanlin L Wang, Xiao-Jun Ma, Robert Monroe, Yuling Luo, Zongming Chen, Haiyan Liu
Objectives: Inconsistent data on detection of albumin expression by ribonucleic acid (RNA) in situ hybridization have been reported. We investigated the utility of RNAscope (Advanced Cell Diagnostics, Hayward, CA) in detection of albumin in hepatocellular carcinomas (HCCs), intrahepatic cholangiocarcinomas (ICCs), and carcinomas from various organs using manual and automated staining. Methods: RNAscope for albumin detection was performed on 482 cases on tissue microarray sections and on 22 cases of ICC, including 14 surgical resection and eight core biopsy specimens...
May 9, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29744342/intrahepatic-cholangiocarcinoma-are-we-making-progress
#17
EDITORIAL
Andre Gorgen, Nicolas Goldaracena, Wei Zhang, Gonzalo Sapisochin
No abstract text is available yet for this article.
April 2018: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29743818/prognostic-significance-of-cxcl5-expression-in-cancer-patients-a-meta-analysis
#18
Binwu Hu, Huiqian Fan, Xiao Lv, Songfeng Chen, Zengwu Shao
Background: CXCL5 is a member of the CXC-type chemokine family, which has been found to play important roles in tumorigenesis and cancer progression. Recent studies have demonstrated that CXCL5 could serve as a potential prognostic biomarker for cancer patients. However, the prognostic value of CXCL5 is still controversial. Methods: We systematically searched PubMed, Embase and Web of Science to obtain all relevant articles investigating the prognostic significance of CXCL5 expression in cancer patients...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29742944/subcentimetric-incidental-intrahepatic-cholangiocarcinoma-in-an-explant-liver-diagnostic-difficulty-of-a-rare-entity
#19
Suvradeep Mitra, Gude Geethanjali, Sahaj Rathi, Arunanshu Behera, Ashim Das
Incidental intrahepatic cholangiocarcinoma (iCCA) is a rare neoplastic lesion in the explant liver specimens with an approximate incidence of 0.7%. The detection of iCCA is associated with poor prognosis in the posttransplant setting. The occurrence of a subcentimetric iCCA is very rare and poses a major diagnostic challenge to the pathologist. This article presents a rare case of subcentimetric iCCA in a young male in the background of advanced stage chronic liver disease resulting from autoimmune hepatitis possibly with chronic cholangiopathy along with the histomorphological differentials...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29742707/surgical-treatment-for-metastasis-from-lymphoepithelioma-like-cholangiocarcinoma-in-the-liver-a-case-report
#20
Jun-Wei Zhang, Hua-Yu Yang, Yi-Yao Xu, Xin-Ting Sang, Shuang-Ni Yu, Han-Chun Huang, Jin Bian, Jian-Ping Xiong, Xin Lu
RATIONALE: Lymphoepithelioma-like cholangiocarcinoma (LEL-CC) is a rare variant of intrahepatic cholangiocarcinoma (ICC), which is characterized by the better outcome than normal ICC. There is no report about the treatment for the metastasis of the LEL-CC. Here, we describe a rare case of LEL-CC of the liver and report the treatment for metastasis of it. PATIENT CONCERNS: A 38-year-old woman with a chronic hepatitis B infection was referred to the department of liver surgery in our hospital with a mass in the liver...
May 2018: Medicine (Baltimore)
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