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Collagen 18

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https://www.readbyqxmd.com/read/27918352/corneal-collagen-cross-linking-for-keratoconus-in-pediatric-patients-long-term-results
#1
Prema Padmanabhan, Sudhir Rachapalle Reddi, Rama Rajagopal, Radhika Natarajan, Geetha Iyer, Bhaskar Srinivasan, Niveditha Narayanan, Meena Lakshmipathy, Shweta Agarwal
PURPOSE: To report the long-term outcome of corneal collagen cross-linking (CXL) for progressive keratoconus in pediatric patients. METHODS: "Epithelium-off" CXL was performed in pediatric eyes with progressive keratoconus. Spectacle-corrected distance visual acuity (CDVA), retinoscopy, topography, and tomography were documented preoperatively and postoperatively at 3 months, 6 months, 1 year, and annually thereafter. RESULTS: A total of 377 eyes of 336 pediatric patients aged 8 to 18 years with progressive keratoconus underwent CXL...
December 1, 2016: Cornea
https://www.readbyqxmd.com/read/27917847/poultry-products-enriched-with-nutricines-have-beneficial-effects-on-human-health
#2
Gordana Kralik, Zlata Kralik
The paper presents nutritive value of broiler meat and table eggs, as these animal products are used for human nutrition on a daily basis. In the Republic of Croatia, average consumption of poultry meat amounts to 18.3 kg and to 160 eggs per capita.The most quality parts of broiler carcass are breasts and drumsticks with thighs. Breast muscles contain 21-23% protein, 1.90-1.97% fat, 75.28-76.01% water and 0.74-0.77% collagen. Thigh muscles contain 4.70-6.05% fat, 19.03-19.93% protein and 0.91-1.13% collagen...
February 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/27903450/low-energy-impact-of-human-cartilage-predictors-for-microcracking-the-network-of-collagen
#3
B Kaleem, F Maier, H Drissi, D M Pierce
OBJECTIVE: We aimed to determine the minimum mechanical impact to cause microstructural damage in the network of collagen (microcracking) within human cartilage and hypothesized that energies below 0.1 J or 1 mJ/mm(3) would suffice. DESIGN: We completed 108 low-energy impact tests (0.05, 0.07, or 0.09 J; 0.75 or 1.0 m/s(2)) using healthy cartilage specimens from six male donors (30.2 ± 8.8 yrs old). Before and after impact we acquired, imaging the second harmonic generation (SHG), ten images from each specimen (50 μm depth, 5 μm step size), resulting in 2160 images...
November 27, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27900469/holocene-changes-in-the-trophic-ecology-of-an-apex-marine-predator-in-the-south-atlantic-ocean
#4
Damián G Vales, Luis Cardona, Atilio F Zangrando, Florencia Borella, Fabiana Saporiti, R Natalie P Goodall, Larissa Rosa de Oliveira, Enrique A Crespo
Predators may modify their diets as a result of both anthropogenic and natural environmental changes. Stable isotope ratios of nitrogen and carbon in bone collagen have been used to reconstruct the foraging ecology of South American fur seals (Arctocephalus australis) in the southwestern South Atlantic Ocean since the Middle Holocene, a region inhabited by hunter-gatherers by millennia and modified by two centuries of whaling, sealing and fishing. Results suggest that the isotopic niche of fur seals from Patagonia has not changed over the last two millennia (average for the period: δ(13)C2200-0BP = -13...
November 29, 2016: Oecologia
https://www.readbyqxmd.com/read/27900440/role-of-methotrexate-chronotherapy-in-collagen-induced-rheumatoid-arthritis-in%C3%A2-rats
#5
X Wang, X Yan, F Wang, F Ge, Z Li
AIM: To explore the circadian rhythm of serum interleukin (IL)-6 in collagen-induced arthritis (CIA) rats and compare the safety and effectiveness of methotrexate (MTX) administered traditionally and via chronotherapy. METHODS: CIA rat models were immunized with bovine type II collagen. Serum IL-6 levels in normal and CIA rats were measured at 2, 6, 10, 14, 18, or 22 h after the light was turned on (HALO). MTX was administered to 6 HALO/18 HALO experimental groups of Wistar rats once daily according to the IL-6 rhythm...
November 29, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27891193/in-epithelial-cancers-aberrant-col17a1-promoter-methylation-predicts-its-misexpression-and-increased-invasion
#6
Pulari U Thangavelu, Tibor Krenács, Eloise Dray, Pascal H G Duijf
BACKGROUND: Metastasis is a leading cause of death among cancer patients. In the tumor microenvironment, altered levels of extracellular matrix proteins, such as collagens, can facilitate the first steps of cancer cell metastasis, including invasion into surrounding tissue and intravasation into the blood stream. However, the degree of misexpression of collagen genes in tumors remains understudied, even though this knowledge could greatly facilitate the development of cancer treatment options aimed at preventing metastasis...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27890611/histone-methyltransferase-setdb1-is-indispensable-for-meckel-s-cartilage-development
#7
Kohei Yahiro, Norihisa Higashihori, Keiji Moriyama
The histone methyltransferase Setdb1 represses gene expression by catalyzing lysine 9 of histone H3 trimethylation. Given that the conventional knockout of Setdb1 is embryo-lethal at the implantation stage, its role in craniofacial development is poorly understood. Here, we investigated the role of Setdb1, using conditional knockout mice-in which Setdb1 was deleted in the Meckel's cartilage (Setdb1 CKO)-and the mouse chondrogenic cell line ATDC5-in which Setdb1 was inhibited by siRNA. Deletion of Setdb1 in Meckel's cartilage, the supportive tissue in the embryonic mandible, led to its enlargement, instead of the degeneration that normally occurs...
November 24, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27888285/efficacy-of-statins-for-osteoporosis-a-systematic-review-and-meta-analysis
#8
REVIEW
T An, J Hao, S Sun, R Li, M Yang, G Cheng, M Zou
Our meta-analysis assessed the efficacy of statins on the risk of fracture, bone mineral density (BMD), and the markers of bone metabolism by collecting data from 33 clinical trials. We found that statin treatment was associated with bone metabolism. And statins seemed to be more effective on male patients with osteoporosis. The efficacy of statins for the treatment of osteoporosis has been controversial in previous studies and meta-analyses. Our meta-analysis was conducted to examine in detail the efficacy of statins on osteoporosis...
November 25, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27885521/laser-and-led-phototherapy-on-midpalatal-suture-after-rapid-maxilla-expansion-raman-and-histological-analysis
#9
Cristiane Becher Rosa, Fernando Antonio Lima Habib, Telma Martins de Araújo, Jean Nunes Dos Santos, Maria Cristina T Cangussu, Artur Felipe Santos Barbosa, Isabele Cardoso Vieira de Castro, Antônio Luiz Barbosa Pinheiro
The aim of this study was to analyze the effect of laser or LED phototherapy on the acceleration of bone formation at the midpalatal suture after rapid maxilla expansion. Forty-five rats were divided into groups at 7 days (control, expansion, expansion and laser irradiation, and expansion and LED irradiation) and into 14 days (expansion, expansion and laser in the 1st week, expansion and LED in the 1st week, expansion and laser in the 1st and 2nd weeks, expansion and LED in the 1st and 2nd weeks). Laser/LED irradiation occurred every 48 h...
November 24, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27879282/sex-related-discordance-between-aortic-valve-calcification-and-hemodynamic-severity-of-aortic-stenosis-is-valvular-fibrosis-the-explanation
#10
Louis Simard, Nancy Côté, François Dagenais, Patrick Mathieu, Christian Couture, Sylvain Trahan, Yohan Bossé, Siamak Mohammadi, Sylvain Pagé, Philippe Joubert, Marie-Annick Clavel
RATIONALE: Calcific aortic stenosis (AS) is characterized by calcium deposition in valve leaflets. However, women present lower aortic valve calcification (AVC) loads than men for the same AS hemodynamic severity. OBJECTIVE: We thus aimed to assess sex-differences in aortic valve fibro-calcific remodelling. METHODS AND RESULTS: One hundred and twenty-five patients underwent Doppler-echocardiography and multidetector-computed-tomography within 3 months prior to aortic valve replacement...
November 22, 2016: Circulation Research
https://www.readbyqxmd.com/read/27876074/combined-detection-of-serum-ctx-ii-and-comp-concentrations-in-osteoarthritis-model-rabbits-an-effective-technique-for-early-diagnosis-and-estimation-of-disease-severity
#11
Bin Bai, Yanqin Li
BACKGROUND: Early diagnosis of osteoarthritis (OA) is difficult. Cartilage oligomeric matrix protein (COMP) and crosslinked C-telopeptides of type II collagen (CTX-II) are two markers which can potentially predict the destruction of articular cartilage of early OA. To comprehensively evaluate the diagnosis value of serum COMP and CTX-II markers in OA, the longitudinal and combined measurement of serum COMP and CTX-II were performed at different stages of pathological process of OA in adult rabbits with OA, compared with the sham-operated rabbits...
November 22, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27875930/hybrid-aorta-constructs-via-in-situ-crosslinking-of-poly-glycerol-sebacate-elastomer-within-a-decellularized-matrix
#12
Selcan Guler, Pezhman Hosseinian, Halil Murat Aydin
Decellularization of tissues and organs has high potential to obtain unique conformation and composition as native tissue structure but may result with weaken tissue mechanical strength. In this study poly(glycerol-sebacate) (PGS) elastomers were combined with decellularized aortae fragments to investigate the changes in mechanical properties. PGS prepolymer was synthesized via microwave irradiation then in-situ cross-linked within the decellularized aorta ECM. Tensile strength (σ) values were found comparable as 0...
November 22, 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/27875656/involvement-of-jnk-in-tnf%C3%AE-driven-remodelling
#13
Irene Mj Eurlings, Niki L Reynaert, Cheryl van de Wetering, Scott W Aesif, Evi M Mercken, Rafael de Cabo, Jos L van der Velden, Yvonne M Janssen-Heininger, Emiel F M Wouters, Mieke A Dentener
Lung tissue remodeling in chronic obstructive pulmonary disease (COPD) is characterized by airway wall thickening and/or emphysema. Although the bronchial and alveolar compartments are functionally independent entities, we recently showed comparable alterations in matrix composition comprised of decreased elastin content and increased collagen and hyaluronan contents of alveolar and small airway walls. Out of several animal models tested SPC-TNFα mice showed remodelling in alveolar and airway walls similar to what is observed in COPD patients...
November 22, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27869651/pericyte-myd88-and-irak4-control-inflammatory-and-fibrotic-responses-to-tissue-injury
#14
Irina A Leaf, Shunsaku Nakagawa, Bryce G Johnson, Jin Joo Cha, Kristen Mittelsteadt, Kevin M Guckian, Ivan G Gomez, William A Altemeier, Jeremy S Duffield
Fibrotic disease is associated with matrix deposition that results in the loss of organ function. Pericytes, the precursors of myofibroblasts, are a source of pathological matrix collagens and may be promising targets for treating fibrogenesis. Here, we have shown that pericytes activate a TLR2/4- and MyD88-dependent proinflammatory program in response to tissue injury. Similarly to classic immune cells, pericytes activate the NLRP3 inflammasome, leading to IL-1β and IL-18 secretion. Released IL-1β signals through pericyte MyD88 to amplify this response...
November 21, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27868076/synovial-c-shaped-tibial-footprint-of-the-anterior-cruciate-ligament
#15
César Janovsky, Camila Cohen Kaleka, Maria Teresa Seixas Alves, Mario Ferretti, Moises Cohen
BACKGROUND: Although numerous anatomic studies about the anterior cruciate ligament (ACL) structure and attachments have been performed, these studies have not reached consensus on the ACL footprint. PURPOSE: To investigate the existing controversy regarding the morphology of the tibial ACL insertion (footprint) and confirm histologically that the tibial ACL footprint is not completely filled with ligament tissue. STUDY DESIGN: Descriptive laboratory study...
November 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27864629/cytokeratin-ae1-ae3-immunostaining-and-3d-histology-improvement-of-diagnosis-in-desmoplastic-squamous-cell-carcinoma-of-the-skin
#16
Katrin Schweinzer, Lukas Kofler, Jürgen Bauer, Gisela Metzler, Helmut Breuninger, Hans-Martin Häfner
Desmoplastic squamous cell carcinoma (DSCC) as a rare subtype of cutaneous SCC has specific histological features, characterized by columns, bands, and strands of squamoid cells infiltrating a dense collagenous stroma. To decrease the high rates of local recurrence in DSSC, improvement of diagnostic methods is highly demanded. Objective was to evaluate whether immunohistochemistry (IHC) is suited to increase diagnostic accuracy. A total number of 18 patients were included in this study. After recutting of the original paraffin blocks, parallel staining of serial sections with conventionally H&E and cytokeratin AE1/AE3-immunohistochemical staining was performed...
November 18, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27862448/a-protocol-for-pressurized-liquid-extraction-and-processing-methods-to-isolate-modern-and-ancient-bone-cholesterol-for-compound-specific-stable-isotope-analysis
#17
Ann O Laffey, John Krigbaum, Andrew R Zimmerman
RATIONALE: Bone lipid compound-specific isotope analysis (CSIA) and bone collagen and apatite stable isotope ratio analysis are important sources of ecological and paleodietary information. Pressurized liquid extraction (PLE) is quicker and utilizes less solvent than traditional methods of lipid extraction such as soxhlet and ultrasonication. This study facilitates dietary analysis by optimizing and testing a standardized methodology for PLE of bone cholesterol. METHODS: Modern and archaeological bone were extracted by PLE using varied temperatures, solvent solutions, and sample weights...
November 8, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27859600/differences-in-extracellular-matrix-proteins-between-friesian-horses-with-aortic-rupture-unaffected-friesians-and-warmblood-horses
#18
M Ploeg, A Gröne, C H A van de Lest, V Saey, L Duchateau, P Wolsein, K Chiers, R Ducatelle, P R van Weeren, M de Bruijn, C Delesalle
BACKGROUND: Aortic rupture is quite common in Friesian horses unlike in Warmblood horses and a hereditary trait is suspected in Friesians. The aortic connective tissue in affected Friesians shows histological changes such as medial necrosis, elastic fibre fragmentation, mucoid material accumulation and fibrosis with aberrant collagen morphology. However, ultrastructural examination of the collagen fibres of the mid-thoracic aorta was inconclusive when trying to further elucidate the pathogenesis of the disease...
November 16, 2016: Equine Veterinary Journal
https://www.readbyqxmd.com/read/27845246/palmitate-promotes-inflammatory-responses-and-cellular-senescence-in-cardiac-fibroblasts
#19
Marina Sokolova, Leif Erik Vinge, Katrine Alfsnes, Maria Belland Olsen, Lars Eide, Ole Jørgen Kaasbøll, Håvard Attramadal, May-Kristin Torp, Linn E Fosshaug, Azita Rashidi, Egil Lien, Alexandra Vanessa Finsen, Øystein Sandanger, Pål Aukrust, Trine Ranheim, Arne Yndestad
Palmitate triggers inflammatory responses in several cell types, but its effects on cardiac fibroblasts are at present unknown. The aims of the study were to (1) assess the potential of palmitate to promote inflammatory signaling in cardiac fibroblasts through TLR4 and the NLRP3 inflammasome and (2) characterize the cellular phenotype of cardiac fibroblasts exposed to palmitate. We examined whether palmitate induces inflammatory responses in cardiac fibroblasts from WT, NLRP3(-/-) and ASC(-/-)mice (C57BL/6 background)...
November 12, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27835899/lung-tissue-remodelling-in-mct-induced-pulmonary-hypertension-a-proposal-for-a-novel-scoring-system-and-changes-in-extracellular-matrix-and-fibrosis-associated-gene-expression
#20
Marcus Franz, Katja Grün, Stefan Betge, Ilonka Rohm, Bernadin Ndongson-Dongmo, Reinhard Bauer, P Christian Schulze, Michael Lichtenauer, Iver Petersen, Dario Neri, Alexander Berndt, Christian Jung
Pulmonary hypertension (PH) is associated with vasoconstriction and remodelling. We studied lung tissue remodelling in a rat model of PH with special focus on histology and extracellular matrix (ECM) remodelling. After induction of PH by monocrotaline, lung tissue was analysed histologically, by gene expression analysis and immunofluorescence labelling of ED-A domain containing fibronectin (ED-A+ Fn), B domain containing tenascin-C (B+ Tn-C) as well as alpha-smooth muscle actin (α-SMA). Serum concentrations of ED-A+ Fn were determined by ELISA...
November 8, 2016: Oncotarget
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