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https://www.readbyqxmd.com/read/28438710/a-purpose-built-neck-coil-for-black-blood-dante-prepared-carotid-artery-imaging-at-7t
#1
Konstantinos Papoutsis, Linqing Li, Jamie Near, Stephen Payne, Peter Jezzard
Atherosclerotic plaques in the bifurcation of the carotid arteries can pose a significant health risk due to possible plaque rupture and subsequent stroke. The assessment of plaques, and evaluation of the risk they pose, can be performed with Black-Blood (BB) vessel wall magnetic resonance imaging. However, resolution at standard clinical field strengths (up to 3T) is limited, hampering reliable assessment and diagnosis. The aim of this study was to investigate the benefits of 7T MRI using a BB application that has been successful at clinical field strengths...
April 21, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28437920/cmos-integrated-gan-led-array-for-discrete-power-level-stepping-in-visible-light-communications
#2
Alexander D Griffiths, Mohamed Sufyan Islim, Johannes Herrnsdorf, Jonathan J D McKendry, Robert Henderson, Harald Haas, Erdan Gu, Martin D Dawson
We report a CMOS integrated micro-LED array capable of generating discrete optical output power levels. A 16 × 16 array of individually addressable pixels are on-off controlled through parallel logic signals. With carefully selected groups of LEDs driven together, signals suitable for discrete transmission schemes are produced. The linearity of the device is assessed, and data transmission using pulse amplitude modulation (PAM) and orthogonal frequency division multiplexing (OFDM) is performed. Error-free transmission at a symbol rate of 100 MSamples/s is demonstrated with 4-PAM, yielding a data rate of 200 Mb/s...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28428213/clinically-feasible-microstructural-mri-to-quantify-cervical-spinal-cord-tissue-injury-using-dti-mt-and-t2-weighted-imaging-assessment-of-normative-data-and-reliability
#3
A R Martin, B De Leener, J Cohen-Adad, D W Cadotte, S Kalsi-Ryan, S F Lange, L Tetreault, A Nouri, A Crawley, D J Mikulis, H Ginsberg, M G Fehlings
BACKGROUND AND PURPOSE: DTI, magnetization transfer, T2*-weighted imaging, and cross-sectional area can quantify aspects of spinal cord microstructure. However, clinical adoption remains elusive due to complex acquisitions, cumbersome analysis, limited reliability, and wide ranges of normal values. We propose a simple multiparametric protocol with automated analysis and report normative data, analysis of confounding variables, and reliability. MATERIALS AND METHODS: Forty healthy subjects underwent T2WI, DTI, magnetization transfer, and T2*WI at 3T in <35 minutes using standard hardware and pulse sequences...
April 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28423235/hepatic-sinusoidal-obstruction-syndrome-during-maintenance-therapy-of-childhood-acute-lymphoblastic-leukemia-is-associated-with-continuous-asparaginase-therapy-and-mercaptopurine-metabolites
#4
Linea Natalie Toksvang, Silvia De Pietri, Stine N Nielsen, Jacob Nersting, Birgitte K Albertsen, Peder S Wehner, Steen Rosthøj, Päivi M Lähteenmäki, Daniel Nilsson, Tove A Nystad, Kathrine Grell, Thomas L Frandsen, Kjeld Schmiegelow
BACKGROUND: Hepatic sinusoidal obstruction syndrome (SOS) during treatment of childhood acute lymphoblastic leukemia (ALL) has mainly been associated with 6-thioguanine. The occurrence of several SOS cases after the introduction of extended pegylated asparaginase (PEG-asparaginase) therapy in the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL2008 protocol led us to hypothesize that PEG-asparaginase, combined with other drugs, may trigger SOS during 6-thioguanine-free maintenance therapy...
April 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28414231/organic-phosphorescence-nanowire-lasers
#5
Zhenyi Yu, Yishi Wu, Lu Xiao, Jianwei Chen, Qing Liao, Jiannian Yao, Hongbing Fu
Organic solid-state lasers (OSSLs) based on singlet fluorescence have merited intensive study as an important class of light sources. Although the use of triplet phosphors has led to 100% internal quantum efficiency in organic light-emitting diodes (OLEDs), stumbling blocks in triplet lasing include generally forbidden intersystem crossing (ISC) and a low quantum yield of phosphorescence (ΦP). Here, we reported the first triplet-phosphorescence OSSL from a nanowire microcavity of a sulfide-substituted difluoroboron compound...
April 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28412455/effects-of-rf-pulse-profile-and-intra-voxel-phase-dispersion-on-mr-fingerprinting-with-balanced-ssfp-readout
#6
Su-Chin Chiu, Te-Ming Lin, Jyh-Miin Lin, Hsiao-Wen Chung, Cheng-Wen Ko, Martin Büchert, Michael Bock
PURPOSE: To investigate possible errors in T1 and T2 quantification via MR fingerprinting with balanced steady-state free precession readout in the presence of intra-voxel phase dispersion and RF pulse profile imperfections, using computer simulations based on Bloch equations. MATERIALS AND METHODS: A pulse sequence with TR changing in a Perlin noise pattern and a nearly sinusoidal pattern of flip angle following an initial 180-degree inversion pulse was employed...
April 13, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28400024/impact-of-a-combined-processing-technology-involving-ultrasound-and-pulsed-light-on-structural-and-physiological-changes-of-saccharomyces-cerevisiae-ke-162-in-apple-juice
#7
Mariana Ferrario, Sandra Guerrero
This study analyzed the effect of single ultrasound (US) (600 W, 20 kHz and 95.2 μm wave amplitude, 10 or 30 min at 20 or 44 ± 1 °C), or combined with pulsed light technology (PL) with controlled heat build-up (Xenon lamp, 3 pulses/s, 71.6 J/cm(2), temperature ranges: 2-20 ± 1 °C and 44-56 ± 1 °C) on the inactivation of Saccharomyces cerevisiae KE 162 cells in commercial (pH: 3.5 ± 0.1; 12.5 ± 0.1 °Brix) and freshly pressed (pH: 3.4 ± 0.1; 12.6 ± 0.1 °Brix) apple juices...
August 2017: Food Microbiology
https://www.readbyqxmd.com/read/28393009/a-case-of-anti-aminoacyl-trna-synthetase-ars-antibody-positive-polymyositis-pm-dermatomyositis-dm-associated-interstitial-pneumonia-ip-successfully-controlled-with-bosentan-therapy
#8
Tomoyuki Naito, Yosuke Tanaka, Mitsunori Hino, Akihiko Gemma
A 72-year-old woman was admitted to our hospital and was diagnosed with interstitial pneumonia (IP) associated with amyopathic dermatomyositis (ADM). The patient experienced three acute IP exacerbations in the 7 years that followed, which were each treated and resolved with steroid pulse therapy. The patient was closely examined for respiratory failure with right heart catheterization (RHC), which demonstrated that she had a mean pulmonary artery pressure (mPAP) of 34 mmHg. The patient was thus diagnosed as having pulmonary hypertension (PH) associated with anti-synthetase syndrome (ASS) and was started on bosentan therapy, which led to improvements in mPAP as well as in subjective symptoms over time...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28391420/a-neuro-oncologist-s-perspective-on-management-of-brain-metastases-in-patients-with-egfr-mutant-non-small-cell-lung-cancer
#9
REVIEW
Tresa McGranahan, Seema Nagpal
Management of non-small cell lung cancer (NSCLC) with brain metastasis (BrM) has been revolutionized by identification of molecular subsets that have targetable oncogenes. Historically, survival for NSCLC with symptomatic BrM was weeks to months. Now, many patients are surviving years with limited data to guide treatment decisions. Tumors with activating mutations in epidermal growth factor receptor (EGFRact+) have a higher incidence of BrM, but a longer overall survival. The high response rate of both systemic and BrM EGFRact+ NSCLC to tyrosine kinase inhibitors (TKIs) has led to the rapid incorporation of new therapies but is outpacing evidence-based decisions for BrM in NSCLC...
April 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28386234/high-intensity-interval-training-in-normobaric-hypoxia-improves-cardiorespiratory-fitness-in-overweight-chinese-young-women
#10
Zhaowei Kong, Qingde Shi, Jinlei Nie, Tomas K Tong, Lili Song, Longyan Yi, Yang Hu
Previous studies have investigated the effects of high-intensity interval training (HIIT) on cardiorespiratory fitness and body composition in overweight populations. However, the additive effect of HIIT and hypoxia on health parameters is not clear. This study compared the effects of HIIT under hypoxic conditions on cardiometabolic function with that under normoxia in overweight Chinese young women. Methods: A double-blind randomized controlled experimental design was applied. Twenty-four sedentary overweight Chinese young women (weight: 68...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28380805/monolithic-optical-link-in-silicon-on-insulator-cmos-technology
#11
Satadal Dutta, Vishal Agarwal, Raymond J E Hueting, Jurriaan Schmitz, Anne-Johan Annema
This work presents a monolithic laterally-coupled wide-spectrum (350 nm < λ < 1270 nm) optical link in a silicon-on-insulator CMOS technology. The link consists of a silicon (Si) light-emitting diode (LED) as the optical source and a Si photodiode (PD) as the detector; both realized by vertical abrupt n<sup>+</sup>p junctions, separated by a shallow trench isolation composed of silicon dioxide. Medium trench isolation around the devices along with the buried oxide layer provides galvanic isolation...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28380756/improvements-of-mesopic-luminance-for-light-emitting-diode-based-outdoor-light-sources-via-tuning-scotopic-photopic-ratios
#12
Tingzhu Wu, Yijun Lu, Ziquan Guo, Lili Zheng, Honghui Zhu, Yao Xiao, Tien-Mo Shih, Yue Lin, Zhong Chen
Outdoor light sources must guarantee excellent mesopic luminance (Lmes) for traffic safety at night. Here, we propose a solution to improve mesopic-related parameters, which include especially the scotopic/photopic ratio and the Lmes, of multi-chip light-emitting diode (LED) light sources. Generally, these sources are driven by pulse-width-modulation currents, and possess readily-controlled spectral power distributions (SPDs). An updated version of the optical power ratio algorithm developed in this article can select suitable overall SPDs and yield corresponding duty cycles to drive individual chips at different correlated-color temperatures and operating temperatures...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28379118/on-the-forming-mechanism-of-the-cleaning-airflow-of-pulse-jet-fabric-filters
#13
Cai Jiying, Hao Wenge, Zhang Cong, Yu Jiaqi, Wang Ting
To reveal the formation mechanism of a pulse-jet airflow's cleaning effect in a filter bag, a theoretical model is built by using the theory of gas jet and unitary adiabatic flow according to given specifications and dimensions of the bags and resistance characteristics of the cloth and dust layer. It is about the relationship between cleaning system structure and operating parameters. The model follows the principle that the flow and kinetic energy of jet flow injected into a filter bag should be consistent with the flow of cleaning airflow in the bag and the pressure drop flowing through the filter cloth and dust layer...
April 5, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28377874/global-mrna-sequencing-of-human-skeletal-muscle-search-for-novel-exercise-regulated-myokines
#14
S Pourteymour, K Eckardt, T Holen, T Langleite, Sindre Lee, J Jensen, K I Birkeland, C A Drevon, M Hjorth
OBJECTIVE: Skeletal muscle is an important secretory organ, producing and releasing numerous myokines, which may be involved in mediating beneficial health effects of physical activity. More than 100 myokines have been identified by different proteomics approaches, but these techniques may not detect all myokines. We used mRNA sequencing as an untargeted approach to study gene expression of secreted proteins in skeletal muscle upon acute as well as long-term exercise. METHODS: Twenty-six middle-aged, sedentary men underwent combined endurance and strength training for 12 weeks...
April 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28374996/comparing-the-resistance-resilience-and-stability-of-replicate-moving-bed-biofilm-and-suspended-growth-combined-nitritation-anammox-reactors
#15
G F Wells, Y Shi, M Laureni, A Rosenthal, I Szivák, D G Weissbrodt, A Joss, H Buergmann, D R Johnson, E Morgenroth
Combined partial nitritation-anammox (PN/A) systems are increasingly being employed for sustainable removal of nitrogen from wastewater, but process instabilities present ongoing challenges for practitioners. The goal of this study was to elucidate differences in process stability between PN/A process variations employing two distinct aggregate types: biofilm [in moving bed biofilm reactors (MBBRs)] and suspended growth biomass. Triplicate reactors for each process variation were studied under baseline conditions and in response to a series of transient perturbations...
April 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28363955/dendritic-cells-engineered-to-overexpress-25-hydroxyvitamin-d-1%C3%AE-hydroxylase-and-pulsed-with-a-myelin-antigen-provide-myelin-specific-suppression-of-ongoing-experimental-allergic-encephalomyelitis
#16
Chih-Huang Li, Jintao Zhang, David J Baylink, Xiaohua Wang, Naga Bharani Goparaju, Yi Xu, Samiksha Wasnik, Yanmei Cheng, Edmundo Carreon Berumen, Xuezhong Qin, Kin-Hing William Lau, Xiaolei Tang
Multiple sclerosis (MS) is caused by immune-mediated damage of myelin sheath. Current therapies aim to block such immune responses. However, this blocking is not sufficiently specific and hence compromises immunity, leading to severe side effects. In addition, blocking medications usually provide transient effects and require frequent administration, which further increases the chance to compromise immunity. In this regard, myelin-specific therapy may provide the desired specificity and a long-lasting therapeutic effect by inducing myelin-specific regulatory T (Treg) cells...
March 31, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28362791/in-vivo-photoacoustic-imaging-of-vasculature-with-a-low-cost-miniature-light-emitting-diode-excitation
#17
Xianjin Dai, Hao Yang, Huabei Jiang
In this Letter, we present a photoacoustic imaging (PAI) system based on a low-cost high-power miniature light emitting diode (LED) that is capable of in vivo mapping vasculature networks in biological tissue. Overdriving with 200 ns pulses and operating at a repetition rate of 40 kHz, a 1.2 W 405 nm LED with a radiation area of 1000  μm×1000  μm and a size of 3.5  mm×3.5  mm was used to excite photoacoustic signals in tissue. Phantoms including black stripes, lead, and hair were used to validate the system in which a volumetric PAI image was obtained by scanning the transducer and the light beam in a two-dimensional x-y plane over the object...
April 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28362405/local-field-fluorescence-microscopy-imaging-cellular-signals-in-intact-hearts
#18
Yuriana Aguilar-Sanchez, Diego Fainstein, Rafael Mejia-Alvarez, Ariel L Escobar
In the heart, molecular signaling studies are usually performed in isolated myocytes. However, many pathological situations such as ischemia and arrhythmias can only be fully understood at the whole organ level. Here, we present the spectroscopic technique of local field fluorescence microscopy (LFFM) that allows the measurement of cellular signals in the intact heart. The technique is based on a combination of a Langendorff perfused heart and optical fibers to record fluorescent signals. LFFM has various applications in the field of cardiovascular physiology to study the heart under normal and pathological conditions...
March 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28353560/a-life-threatening-case-of-tafro-syndrome-with-dramatic-response-to-tocilizumab-rituximab-and-pulse-steroids-the-first-case-report-in-latin-america
#19
Fabio Freire José, Lucila Nassif Kerbauy, Guilherme Fleury Perini, Danielle Isadora Blumenschein, Denise da Cunha Pasqualin, Denise Maria Avancini Costa Malheiros, Guilherme de Carvalho Campos Neto, Fabio Pires de Souza Santos, Ronaldo Piovesan, Nelson Hamerschlak
RATIONALE: This is the report of the first case of TAFRO syndrome (Thrombocytopenia, Anasarca, myelofibrosis, Renal dysfunction, Organomegaly) in Latin America. PATIENT CONCERNS: The patient was a 61-year-old white woman of Ashkenazi Jewish descent, who presented with a history of 8 days of nausea, vomiting, and fever; severe pitting edema in both legs, ascites, splenomegaly, and palpable axillary lymph nodes. DIAGNOSES: Abdominal computed tomography (CT) showed bilateral pleural effusion and retroperitoneal lymph node enlargement...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28352994/impact-of-micellar-surfactant-on-supersaturation-and-insight-into-solubilization-mechanisms-in-supersaturated-solutions-of-atazanavir
#20
Anura S Indulkar, Huaping Mo, Yi Gao, Shweta A Raina, Geoff G Z Zhang, Lynne S Taylor
PURPOSE: The goals of this study were to determine: 1) the impact of surfactants on the "amorphous solubility"; 2) the thermodynamic supersaturation in the presence of surfactant micelles; 3) the mechanism of solute solubilization by surfactant micelles in supersaturated solutions. METHODS: The crystalline and amorphous solubility of atazanavir was determined in the presence of varying concentrations of micellar sodium dodecyl sulfate (SDS). Flux measurements, using a side-by-side diffusion cell, were employed to determine the free and micellar-bound drug concentrations...
March 28, 2017: Pharmaceutical Research
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