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https://www.readbyqxmd.com/read/29037027/refining-prognostic-stratification-of-human-papillomavirus-related-oropharyngeal-squamous-cell-carcinoma-different-prognosis-between-t1-and-t2
#1
Sumin Lee, Sang-Wook Lee, Sunmin Park, Sang Min Yoon, Jin-Hong Park, Si Yeol Song, Seung Do Ahn, Jong Hoon Kim, Eun Kyung Choi, Su Ssan Kim, Jinhong Jung, Young Seok Kim
PURPOSE: To validate the 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM staging system for human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and investigate whether a modified classification better reflects the prognosis. MATERIALS AND METHODS: Medical records of patients diagnosed with non-metastatic HPV-related OPSCC between 2010 and 2016 at a single institution were retrospectively reviewed...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29036939/female-genital-mutilation-reconstruction-a-preliminary-report
#2
Catherine S Chang, David W Low, Ivona Percec
Background: Female genital mutilation (FGM) is internationally recognized as a violation of human rights. Though rarely discussed, FGM is prevalent, affecting hundreds of millions of females worldwide. Objectives: We believe that is important for plastic surgeons to be informed and prepared to address the surgical and emotional needs of these women. We present our experience on treatment of women subjected to FGM. Methods: Three consecutive patients were treated by our clitoral restoration procedure...
September 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29036897/inhibition-of-starvation-triggered-endoplasmic-reticulum-stress-autophagy-and-apoptosis-in-arpe-19-cells-by-taurine-through-modulating-the-expression-of-calpain-1-and-calpain-2
#3
Yuanyuan Zhang, Shu Ren, Yuci Liu, Kun Gao, Zheng Liu, Zhou Zhang
Age-related macular degeneration (AMD) is a complex disease with multiple initiators and pathways that converge on death for retinal pigment epithelial (RPE) cells. In this study, effects of taurine on calpains, autophagy, endoplasmic reticulum (ER) stress, and apoptosis in ARPE-19 cells (a human RPE cell line) were investigated. We first confirmed that autophagy, ER stress and apoptosis in ARPE-19 cells were induced by Earle's balanced salt solution (EBSS) through starvation to induce RPE metabolic stress...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29036767/the-role-of-glycation-in-the-pathogenesis-of-aging-and-its-prevention-through-herbal-products-and-physical-exercise
#4
Chan-Sik Kim, Sok Park, Junghyun Kim
PURPOSE: Advanced glycation end products (AGEs) are non-enzymatic modifications of proteins or lipids after exposure to sugars. In this review, the glycation process and AGEs are introduced, and the harmful effects of AGEs in the aging process are discussed. METHODS: Results from human and animal studies examining the mechanisms and effects of AGEs are considered. In addition, publications addressing means to attenuate glycation stress through AGE inhibitors or physical exercise are reviewed...
September 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29036636/genetic-reduction-of-nrf2-exacerbates-cognitive-deficits-in-a-mouse-model-of-alzheimer-s-disease
#5
Caterina Branca, Eric Ferreira, Thuy-Vi Nguyen, Kristian Doyle, Antonella Caccamo, Salvatore Oddo
Aging is the major risk factor for several neurodegenerative diseases, including Alzheimer's disease (AD). However, the mechanisms by which aging contributes to neurodegeneration remain elusive. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a transcription factor that regulates expression of a vast number of genes by binding to the antioxidant response element. Nrf2 levels decrease as a function of age, and reduced Nrf2 levels have been reported in postmortem human brains and animal models of AD...
September 19, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29036600/brain-cancer-cluster-investigation-around-a-factory-emitting-dichloromethane
#6
Konstantinos C Makris, Michael Voniatis
Background: The health risks associated with dichloromethane (DCM) for the general population living near industrial activities have not yet been quantified, primarily due to lack of epidemiological datasets. In the absence of such human data, we undertook a cancer cluster investigation in Cyprus around a historically using DCM plant producing shoe soles that were globally exported. We designed the methodology to investigate the possible existence of a cancer cluster in the area around the factory (point zero) and within a radius of 500 meters...
October 4, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29036537/2-fluoroarabinonucleic-acid-modification-traps-g-quadruplex-and-i-motif-structures-in-human-telomeric-dna
#7
Hala Abou Assi, Roberto El-Khoury, Carlos González, Masad J Damha
Human telomeres and promoter regions of genes fulfill a significant role in cellular aging and cancer. These regions comprise of guanine and cytosine-rich repeats, which under certain conditions can fold into G-quadruplex (G4) and i-motif structures, respectively. Herein, we use UV, circular dichroism and NMR spectroscopy to study several human telomeric sequences and demonstrate that G4/i-motif-duplex interconversion kinetics are slowed down dramatically by 2'-β-fluorination and the presence of G4/i-motif-duplex junctions...
September 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036495/the-p16-mir-217-egr1-pathway-modulates-age-related-tenogenic-differentiation-in-tendon-stem-progenitor-cells
#8
Weifeng Han, Bing Wang, Junpeng Liu, Lei Chen
Previous studies have shown that the differentiation potential declines with the age of progenitor cells and is linked to altered levels of senescence markers. The purpose of this study was to test whether senescence marker p16 affects age-related tenogenic differentiation in tendon stem/progenitor cells (TSPCs). Young and aged TSPCs were isolated from young/healthy and aged/degenerated human Achilles tendons, respectively. Cellular aging and capacity for tenogenic differentiation were examined. The results showed that the tenogenic differentiation capacity of TSPCs significantly decreases with advancing age...
September 27, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29036443/the-association-of-perceived-mental-stress-sense-of-purpose-in-life-and-negative-life-events-with-the-risk-of-incident-herpes-zoster-and-postherpetic-neuralgia-the-shez-study
#9
Yukiko Takao, Yoshinobu Okuno, Yasuko Mori, Hideo Asada, Koichi Yamanishi, Hiroyasu Iso
This population-based prospective study examined the relationships of perceived mental stress, sense of purpose in life, and negative life events to the incidence of herpes zoster (HZ) and postherpetic neuralgia (PHN). The data were collected from 12,359 participants (aged ≥50 years old in Shozu County, Kagawa Prefecture, Japan) who answered a self-completed health questionnaire. During a 3-year follow-up between December 2008 and November 2012, HZ and PHN were diagnosed in 400 and 79 subjects, respectively...
September 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29036432/copb2-is-essential-for-embryogenesis-and-hypomorphic-mutations-cause-human-microcephaly
#10
Andrew DiStasio, Ashley Driver, Kristen Sund, Milene Donlin, Ranjith M Muraleedharan, Shabnam Pooya, Beth Kline-Fath, Kenneth M Kaufman, Cynthia A Prows, Elizabeth Schorry, Biplab DasGupta, Rolf W Stottmann
Primary microcephaly is a congenital brain malformation characterized by a head circumference less than three standard deviations below the mean for age and sex and results in moderate to severe mental deficiencies and decreased lifespan. We recently studied two children with primary microcephaly in an otherwise unaffected family. Exome sequencing identified an autosomal recessive mutation leading to an amino acid substitution in a WD40 domain of the highly conserved Coatomer Protein Complex, Subunit Beta 2 (COPB2)...
September 19, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29036415/transfusion-transmissible-infections-among-walk-in-blood-donors-at-kisumu-regional-blood-transfusion-centre-kisumu-county-kenya-2015
#11
Dominic Wamamba, Dickens Onyango, Elvis Oyugi, Evalyne Kanyina, Mark Obonyo, Jane Githuku, James Ransom
Background: Transfusion transmissible infections (TTIs) are threats to blood safety. This study investigated TTIs among volunteer blood donors at the Kisumu Regional Blood Transfusion Centre (KRBTC) in Kenya. Methods: We performed a retrospective record review of blood donor registers at KRBTC, 2015. Walk-in donors accepted for donation were analyzed to determine prevalence of human immunodeficiency virus (HIV), hepatitis B (HBV), hepatitis C (HCV), and syphilis...
September 23, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29036336/missed-opportunities-for-human-papillomavirus-vaccine-initiation-in-an-insured-adolescent-female-population
#12
Claudia M Espinosa, Gary S Marshall, Charles R Woods, Qianli Ma, Derek Ems, Irene Nsiah, Laura E Happe, Michael J Smith
Background: This study assessed the initiation of HPV vaccination in insured adolescent females in relation to physician visits and receipt of other vaccines routinely given at the same age. Methods: January 1, 2010, and September 31, 2015. Vaccination administration was determined by using Current Procedural Terminology codes. A missed opportunity was defined as the absence of an HPV vaccine at the following encounter types: visits with a 4-valent meningococcal conjugate vaccine (MenACWY) or tetanus, diphtheria, and acellular pertussis (Tdap) vaccine claim; well adolescent visits; or any encounter with a primary care provider (PCP)...
September 23, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29035883/association-between-allergies-and-hypercholesterolemia-a-systematic-review
#13
Sara Manti, Caterina Cuppari, Lucia Marseglia, Gabriella D'Angelo, Teresa Arrigo, Eloisa Gitto, Salvatore Leonardi, Carmelo Salpietro
BACKGROUND: There is controversy in the literature regarding the potential relationship between atopic predisposition (AP) and serum cholesterol levels. To this purpose, we reviewed human studies that investigated this possible link. METHODS: Following PRISMA guidelines, a literature search of PubMed and Science Direct for peer-reviewed journal articles in English from January 2003, with updates through to August 2016, was conducted. Relevant publications were reviewed that included pediatric and adult populations...
October 17, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29035751/intercellular-transfer-of-pathogenic-%C3%AE-synuclein-by-extracellular-vesicles-is-induced-by-the-lipid-peroxidation-product-4-hydroxynonenal
#14
Shi Zhang, Erez Eitan, Tsung-Yu Wu, Mark P Mattson
Parkinson's disease (PD) is characterized by accumulations of toxic α-synuclein aggregates in vulnerable neuronal populations in the brainstem, midbrain, and cerebral cortex. Recent findings suggest that α-synuclein pathology can be propagated transneuronally, but the underlying molecular mechanisms are unknown. Advances in the genetics of rare early-onset familial PD indicate that increased production and/or reduced autophagic clearance of α-synuclein can cause PD. The cause of the most common late-onset PD is unclear, but may involve metabolic compromise and oxidative stress upstream of α-synuclein accumulation...
September 22, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29035709/heart-rate-variability-and-salivary-cortisol-in-very-preterm-children-during-school-age
#15
Natalie Urfer-Maurer, Sebastian Ludyga, Tobias Stalder, Serge Brand, Edith Holsboer-Trachsler, Markus Gerber, Alexander Grob, Peter Weber, Sakari Lemola
The autonomic nervous system (ANS) plays a major role in the human stress response and reflects physical and psychological adaptability to a changing environment. Long-term exposure to early life stressors may alter the function of the ANS. The present study examines differences in the ANS between children born very preterm and full-term as well as the association between the ANS and the hypothalamic-pituitary-adrenal (HPA) axis, the other main branch of the human stress system. Fifty-four healthy children born very preterm (<32nd gestational week) and 67 full-term children aged 7-12 years provided data for the present study...
October 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29035677/effectiveness-of-a-smartphone-application-for-the-management-of-metabolic-syndrome-components-focusing-on-weight-loss-a-preliminary-study
#16
Tatiana Toro-Ramos, Dong-Hwa Lee, Youngin Kim, Andreas Michaelides, Tae Jung Oh, Kyoung Min Kim, Hak Chul Jang, Soo Lim
BACKGROUND: There are inconsistent results for the effectiveness of using smartphone applications (apps) or websites on weight loss. We investigated the efficacy of a smartphone intervention using a designated app that utilizes a lifestyle intervention-focused approach, including a human coaching element, toward weight loss in overweight or obese Korean adults. METHODS: One hundred four adults aged 20-60 years with a body mass index ≥23 kg/m(2), who signed up for a smartphone program for weight loss (using the Noom app), were recruited...
October 16, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29035377/nme4-nucleoside-diphosphate-kinase-d-in-cardiolipin-signaling-and-mitophagy
#17
Uwe Schlattner, Malgorzata Tokarska-Schlattner, Richard M Epand, Mathieu Boissan, Marie-Lise Lacombe, Valerian E Kagan
Mitophagy is an emerging paradigm for mitochondrial quality control and cell homeostasis. Dysregulation of mitophagy can lead to human pathologies such as neurodegenerative disorders and contributes to the aging process. Complex protein signaling cascades have been described that regulate mitophagy. We have identified a novel lipid signaling pathway that involves the phospholipid cardiolipin (CL). CL is synthesized and normally confined at the inner mitochondrial membrane. However, upon a mitophagic trigger, ie, collapse of the inner membrane potential, CL is rapidly externalized to the mitochondrial surface with the assistance of the hexameric nucleoside diphosphate kinase D (NME4, NDPK-D, or NM23-H4)...
October 16, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29035332/random-network-models-to-predict-the-long-term-impact-of-hpv-vaccination-on-genital-warts
#18
Javier Díez-Domingo, Víctor Sánchez-Alonso, Rafael-J Villanueva, Luis Acedo, José-Antonio Moraño, Javier Villanueva-Oller
The Human papillomaviruses (HPV) vaccine induces a herd immunity effect in genital warts when a large number of the population is vaccinated. This aspect should be taken into account when devising new vaccine strategies, like vaccination at older ages or male vaccination. Therefore, it is important to develop mathematical models with good predictive capacities. We devised a sexual contact network that was calibrated to simulate the Spanish epidemiology of different HPV genotypes. Through this model, we simulated the scenario that occurred in Australia in 2007, where 12-13 year-old girls were vaccinated with a three-dose schedule of a vaccine containing genotypes 6 and 11, which protect against genital warts, and also a catch-up program in women up to 26 years of age...
October 16, 2017: Viruses
https://www.readbyqxmd.com/read/29035302/oligoarticular-hemarthroses-and-osteomyelitis-complicating-pasteurella-meningitis-in-an-infant
#19
Charles Nathan Nessle, Allison K Black, Justin Farge, Victoria A Statler
A 5-month-old previously healthy female presented with a one-week history of fever and increased fussiness. Her presentation revealed an ill-appearing infant with an exam and cerebrospinal fluid (CSF) studies concerning bacterial meningitis; CSF cultures grew Pasteurella multocida. Additionally, brain magnetic resonance imaging (MRI) demonstrated cervical osteomyelitis. Despite multiple days of antibiotic therapy, she remained febrile with continued pain; MRI showed oligoarticular effusions, and aspiration of these joints yielded bloody aspirates...
October 16, 2017: Children
https://www.readbyqxmd.com/read/29035163/uptake-and-correlates-of-cervical-cancer-screening-among-hiv-infected-women-attending-hiv-care-in-uganda
#20
Rhoda K Wanyenze, John Baptist Bwanika, Jolly Beyeza-Kashesya, Shaban Mugerwa, Jim Arinaitwe, Joseph K B Matovu, Violet Gwokyalya, Dickson Kasozi, Justine Bukenya, Fred Makumbi
BACKGROUND: Human immunodeficiency virus (HIV)-infected women are at high risk of cervical cancer. OBJECTIVE: This study assessed uptake and correlates of cervical screening among HIV-infected women in care in Uganda. METHODS: A nationally representative cross-sectional survey of HIV-infected women in care was conducted from August to November 2016. Structured interviews were conducted with 5198 women aged 15-49 years, from 245 HIV clinics...
2017: Global Health Action
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