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https://www.readbyqxmd.com/read/29684799/elevated-heavy-metals-levels-in-cognitively-impaired-patients-from-pakistan
#1
Ghazala Iqbal, Wahid Zada, Abdul Mannan, Touqeer Ahmed
The deficit in the visuospatial skills, thinking, learning and memory is termed as cognitive impairment. Human exposure to heavy metals is a potential risk factor for developing cognitive impairment. This study aimed to investigate the possible association between the concentration of heavy metals and the extent of cognitive impairment. Blood samples were subjected to microwave assisted acid digestion and evaluated for metals levels using atomic absorption spectrophotometry. We measured the levels of Cu, Pb, Al, Zn, Cd and Mn in 183 patients diagnosed with cognitive impairment; mild (n = 72), moderate (n = 86) and severe (n = 25) and compared them to age-matched healthy controls (n = 90)...
April 16, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29684633/efficacy-of-a-carrageenan-gel-against-transmission-of-cervical-hpv-catch-interim-analysis-of-a-randomized-double-blind-placebo-controlled-phase-2b-trial
#2
Sindy Magnan, Joseph E Tota, Mariam El-Zein, Ann N Burchell, John T Schiller, Alex Ferenczy, Pierre-Paul Tellier, François Coutlée, Eduardo L Franco
OBJECTIVE: We evaluated the efficacy of a carrageenan-based lubricant gel in reducing the risk of genital human papillomavirus (HPV) infections in women. METHODS: We conducted a planned interim analysis of a randomized, double-blind, placebo-controlled, phase 2B trial. Women aged 18 years and older were randomly assigned (1:1) to a carrageenan-based or a placebo gel to be self-applied every other day for the first month and prior to and following each intercourse during follow-up...
April 20, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29684625/nanomechanics-and-ultrastructure-of-the-internal-mammary-artery-adventitia-in-patients-with-low-and-high-pulse-wave-velocity
#3
Zhuo Chang, Paolo Paoletti, Steve D Barrett, Ya Hua Chim, Eva Caamaño-Gutiérrez, Maria Lyck Hansen, Hans Christian Beck, Lars Melholt Rasmussen, Riaz Akhtar
The collagen-rich adventitia is the outermost arterial layer and plays an important biomechanical and physiological role in normal vessel function. While there has been a lot of effort to understand the role of the medial layer on arterial biomechanics, the adventitia has received less attention. In this study, we hypothesized that different ultrastructural and nanomechanical properties would be exhibited in the adventitia of the internal mammary artery (IMA) in patients with a low degree of arterial stiffening as compared to those with a high degree of arterial stiffening...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684495/carcinogenic-and-non-carcinogenic-health-risks-of-metal-oid-s-in-tap-water-from-ilam-city-iran
#4
Yadolah Fakhri, Narottam Saha, Amir Sheikhmohammadi, Milad Rasouli, Moayed Avazpour, Aziz Rahimizadeh, Seyed-Mohammad Riahi, Mansour Ghaderpoori, Hassan Keramati, Bigard Moradi, Nazak Amanidaz, Zahra Baninameh, Amin Mousavi Khaneghah
One of the most important pathways for exposure to metals is drinking water ingestion. Chronic or acute exposure to metals can endanger the health of the exposed population, and hence, estimation of human health risks is crucial. In the current study for the first time, the concentrations of Mercury (Hg), Arsenic (As), Zinc (Zn), Lead (Pb) and Cobalt (Co) in 120 collected tap water samples (2015, July-November) from Ilam city, Iran were investigated using flame atomic absorption spectrophotometer. Also, the metal-induced carcinogenic and non-carcinogenic risks for consumers exposed to tap drinking water were calculated...
April 20, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29684354/updated-distribution-and-experimental-life-history-traits-of-the-recently-invasive-snail-lissachatina-fulica-in-havana-cuba
#5
Antonio A Vázquez, Jorge Sánchez, Annia Alba, Elizabeth Martínez, Luis Alvarez-Lajonchere, Michel Matamoros, James B Coupland
The giant African snail Lissachatina fulica has been reported invading Cuba since 2014 and is now well established in areas of Havana and several nearby regions. This invasive species is of major concern to health authorities given its role as an important vector of parasites such as Angiostrongylus cantonensis, the causative agent of eosinophilic meningoencephalitis in humans. Here, we update the distribution within Cuba. We also report on our studies of experimental life-history traits to assess the population dynamics and potential for spread of this species in Cuba...
April 20, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29684118/spontaneous-endometriosis-in-cynomolgus-monkeys-as-a-clinically-relevant-experimental-model
#6
A Nishimoto-Kakiuchi, S Netsu, S Okabayashi, K Taniguchi, H Tanimura, A Kato, M Suzuki, T Sankai, R Konno
STUDY QUESTION: Does spontaneous endometriosis in cynomolgus monkeys have the characteristics required of a good experimental model? SUMMARY ANSWER: Spontaneous endometriosis in cynomolgus monkeys exhibited similar clinicopathological characteristics to the human disease and was useful as an experimental model. WHAT IS KNOWN ALREADY: The prevalence of endometriosis in autopsied cynomolgus monkeys (Macaca fascicularis) in a breeding colony was reported to be 28...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29684086/frequency-of-appearance-of-transverse-harris-lines-reflects-living-conditions-of-the-pleistocene-bear-ursus-ingressus-sudety-mts-poland
#7
Dariusz Nowakowski
Transverse lines, called Harris Lines (HL), osteological markers of recovery from growth arrest episodes, are visible in radiograms of recent and Pleistocene fossil bones. Since on the one hand they mark stressful episodes in life, and on the other are mainly used to trace health fluctuations in prehistoric human communities, I used a cave bear population to check if the processes that could affect the specie' condition were in any way reflected in the bone structure. 392 bear bones from Bear Cave in Kletno (collection: Department of Palaeozoology, University of Wrocław), dated as 32 100 ±1300 to >49 000 years BP, were radiologically examined...
2018: PloS One
https://www.readbyqxmd.com/read/29683968/functional-correlation-between-the-pancreas-and-the-small-intestine-in-humans-the-first-evaluation-using-a-newly-developed-enteroscopy
#8
Daijuro Hayashi, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takamichi Kuwahara, Manabu Kawai, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Senju Hashimoto, Hidemi Goto
OBJECTIVES: The aim of this study is to evaluate a functional correlation between the pancreas and the small intestine and the association of this relationship with nutritional status, using magnifying enteroscopy. METHODS: The subjects were adults aged 20 years or older who underwent upper gastrointestinal endoscopy. An endoscope was inserted into the jejunum, and 10% glucose was sprayed under magnifying observation to evaluate changes in blood flow in the villous capillary network...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683756/de-novo-expression-of-transfected-sirtuin-3-enhances-susceptibility-of-human-mcf-7-breast-cancer-cells-to-hyperoxia-treatment
#9
Marija Pinterić, Iva I Podgorski, Sandra Sobočanec, Marijana Popović Hadžija, Mladen Paradžik, Ana Dekanić, Maja Marinović, Mirna Halasz, Robert Belužić, Grazia Davidović, Andreja Ambriović Ristov, Tihomir Balog
Sirtuin 3 (Sirt3) has a promising role in cancer tumourigenesis and treatment, but there have been controversies about its role as oncogene or tumour suppressor in different types of cancer. Changes in its expression are associated with the excessive production of reactive oxygen species (ROS), thus contributing to mitochondrial dysfunction and age-related pathologies. Hyperoxic treatment (i.e. generator of ROS) was shown to support some tumourigenic properties, but finally suppresses growth of certain mammary carcinoma cells...
April 23, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29683361/human-recombinant-epidermal-growth-factor-in-skin-lesions-77-cases-in-epitelizando-project
#10
Jordi Esquirol-Caussa, Elisabeth Herrero-Vila
OBJECTIVE: To analyze compounded recombinant human Epidermal Growth Factor (rhEGF) effectiveness on skin lesions through a case series. DESIGN: Multicentric series of skin lesions treated with topical recombinant human Epidermal Growth Factor. SITE: Patients from 56 different health professionals, three different countries, two recruitment years. PARTICIPANTS: 77 patients with skin lesions, mean age 63.15 years (min = 18, max = 95); 53...
April 23, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29683047/using-media-while-interacting-face-to-face-is-associated-with-psychosocial-well-being-and-personality-traits
#11
Mindy Lee, Karen Murphy, Glenda Andrews
Positive face-to-face human interactions are known to benefit well-being. Drawing upon previous work regarding the interference of media (via technological devices or print) in social interaction, the aim of this study was to identify whether using media during face-to-face interaction could potentially limit the positive effect of interaction on well-being. Participants were 437 university students who completed an online survey which assessed media multitasking behaviors, well-being (trait depression, trait anxiety, social anxiety, empathy, and psychological well-being), and personality traits (Big-5 and narcissism)...
January 1, 2018: Psychological Reports
https://www.readbyqxmd.com/read/29682763/differential-expression-of-annexin-2-spink1-and-hsp60-predict-progression-of-prostate-cancer-through-bifurcated-who-gleason-score-categories-in-african-american-men
#12
Desta A Beyene, Tammey J Naab, Norma F Kanarek, Victor Apprey, Ashwini Esnakula, Farahan A Khan, Marc R Blackman, Collis A Brown, Tamaro S Hudson
BACKGROUND: Although studies have observed several markers correlate with progression of prostate cancer (PCa), no specific markers have been identified that accurately predict the progression of this disease, even in African American (AA) men who are generally at higher risk than other ethnic groups. The primary goal of this study was to explore whether three markers could predict the progression of PCa. METHOD: We investigated protein expression of Annexin 2 (ANX2), serine peptidase inhibitor, kazal type 1(SPINK1)/tumor-associated trypsin inhibitor (TATI), and heat shock protein 60 (Hsp60) in 79 archival human prostate trans-rectal ultrasound (TRUS) biopsy tissues according to a modified World Health Organization (WHO) classification: normal (WHO1a), Gleason Score (GS6 (WHO1b), GS7 subgroups (WHO2 = 3 + 4, WHO3 = 4 + 3), GS8 (WHO4), and GS9-10 (WHO5)...
April 22, 2018: Prostate
https://www.readbyqxmd.com/read/29682661/environment-and-human-friendly-colored-materials-prepared-using-black-and-white-components
#13
Yukikazu Takeoka
Our lives in the present age are full of colorful items. However, when many coloring materials cannot be used due to environmental concerns, this colorful life that has been constructed will be diminished. Maintaining our rich lifestyle necessitates the development of technologies that can make safe and secure color materials from materials with less burden on people and the environment. Herein, the author reveals that structural colored materials with little angle dependence can be prepared using various materials with short-range order in the refractive index, which is comparable to the wavelength of visible light, and with the aid of a black substance...
April 23, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29682542/gut-microbial-changes-interactions-and-their-implications-on-human-lifecycle-an-ageing-perspective
#14
REVIEW
Ravichandra Vemuri, Rohit Gundamaraju, Madhur D Shastri, Shakti Dhar Shukla, Krishnakumar Kalpurath, Madeleine Ball, Stephen Tristram, Esaki M Shankar, Kiran Ahuja, Rajaraman Eri
Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host. A growing body of clinical evidence suggests an intricate relationship between the gut microbiota and the immune system. With ageing, the gut microbiota develops significant imbalances in the major phyla such as the anaerobic Firmicutes and Bacteroidetes as well as a diverse range of facultative organisms, resulting in impaired immune responses. Antimicrobial therapy is commonly used for the treatment of infections; however, this may also result in the loss of normal gut flora...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682537/the-potential-virulence-factors-of-providencia-stuartii-motility-adherence-and-invasion
#15
Naziia Kurmasheva, Vyacheslav Vorobiev, Margarita Sharipova, Tatyana Efremova, Ayslu Mardanova
Providencia stuartii is the most common Providencia species capable of causing human infections. Currently P. stuartii is involved in high incidence of urinary tract infections in catheterized patients. The ability of bacteria to swarm on semisolid (viscous) surfaces and adhere to and invade host cells determines the specificity of the disease pathogenesis and its therapy. In the present study we demonstrated morphological changes of P. stuartii NK cells during migration on the viscous medium and discussed adhesive and invasive properties utilizing the HeLa-M cell line as a host model...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682419/inducible-nitric-oxide-synthase-nos2-knockout-mice-as-a-model-of-trichotillomania
#16
Plinio C Casarotto, Caroline Biojone, Karina Montezuma, Fernando Q Cunha, Samia R L Joca, Eero Castren, Francisco S Guimaraes
Background: Trichotillomania (TTM) is an impulse control disorder characterized by repetitive hair pulling/trimming. Barbering behavior (BB) observed in laboratory animals is proposed as a model of TTM. The neurobiological basis of TTM is unclear, but involves striatal hyperactivity and hypoactivation of the prefrontal cortex. Methods: In this study, we evaluated the BB in knockout mice for the inducible isoform of nitric oxide synthase (NOS2KO) and the consequences of silencing this enzyme in PC12 cell differentiation...
2018: PeerJ
https://www.readbyqxmd.com/read/29682403/novel-biomarkers-of-physical-activity-maintenance-in-midlife-women-preliminary-investigation
#17
Kelly A Bosak, Vlad B Papa, Morgan G Brucks, Cary R Savage, Joseph E Donnelly, Laura E Martin
The precision health initiative is leading the discovery of novel biomarkers as important indicators of biological processes or responses to behavior, such as physical activity. Neural biomarkers identified by magnetic resonance imaging (MRI) hold promise to inform future research, and ultimately, for transfer to the clinical setting to optimize health outcomes. This study investigated resting-state and functional brain biomarkers between midlife women who were maintaining physical activity in accordance with the current national guidelines and previously acquired age-matched sedentary controls...
2018: BioResearch Open Access
https://www.readbyqxmd.com/read/29682306/anti-m%C3%A3-llerian-hormone-levels-are-reduced-in-women-living-with-human-immunodeficiency-virus-compared-to-control-women-a-case-control-study-from-copenhagen-denmark
#18
EDITORIAL
Maria Wessman, Anne-Sofie Korsholm, Janne Gasseholm Bentzen, Anders Nyboe Andersen, Magnus Glindvad Ahlström, Terese Lea Katzenstein, Nina Weis
Objectives: Anti-müllerian hormone (AMH) is a marker of ovarian reserve. The purpose of this study was to compare AMH in women living with HIV with an age-matched control group of HIV-uninfected women, and to identify possible variables associated with decreasing AMH levels in women living with HIV. Methods: AMH was measured in frozen EDTA samples from 84 white women living with HIV, aged 20 -40 years, with fully suppressed HIV RNA viral loads for at least 6 months and no hepatitis B or C virus co-infection...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29682281/effects-of-a-phosphocitrate-analogue-on-osteophyte-subchondral-bone-advance-and-bone-marrow-lesions-in-hartley-guinea-pigs
#19
Y Sun, A J Kiraly, A R Sun, M Cox, D R Mauerhan, E N Hanley
Objectives: The objectives of this study were: 1) to examine osteophyte formation, subchondral bone advance, and bone marrow lesions (BMLs) in osteoarthritis (OA)-prone Hartley guinea pigs; and 2) to assess the disease-modifying activity of an orally administered phosphocitrate 'analogue', Carolinas Molecule-01 (CM-01). Methods: Young Hartley guinea pigs were divided into two groups. The first group (n = 12) had drinking water and the second group (n = 9) had drinking water containing CM-01...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29682244/is-there-a-correlation-between-helicobacter-pylori-and-enterohepatic-helicobacter-species-and-gallstone-cholecystitis
#20
Seyed Masih Fatemi, Abbas Doosti, Dariush Shokri, Sadegh Ghorbani-Dalini, Morteza Molazadeh, Hossein Tavakoli, Mohammad Minakari, Hamid Tavakkoli
BACKGROUND Cholecystitis is a common surgical condition. Recently, several authors have reported that DNA of bile tolerant Helicobacter spp. has been found in the human bile colonizing the biliary tract. The aim of this study was to evaluate the association between the presence of Helicobacter spp. and gallstone cholecystitis. METHODS In this case-control study, gallstones, bile, and gallbladder mucosa were collected from 25 patients without gallstone disease, 24 with acute cholecystitis, and 28 with chronic cholecystitis...
January 2018: Middle East Journal of Digestive Diseases
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