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https://www.readbyqxmd.com/read/29145282/autosomal-dominant-polycystic-kidney-disease-combined-with-hypertrophic-cardiomyopathy-a-case-report
#1
Yingjing Shen, Chenggang Xu
INTRODUCTION: This report describes the novel sampling of autosomal dominant polycystic kidney disease (ADPKD) combined with hypertrophic cardiomyopathy (HCM). SYMPTOMS AND CLINICAL FINDINGS: A 48-year-old Chinese man presented with anasarca, hypourocrinia, gross hematuria, and weight gain by 10 kg subsequently developed acute kidney injury after struck by acute respiratory distress syndrome, really a threat to his heart. DIAGNOSES: Abdominal ultrasound revealed multiple small cysts in both kidneys, with the right kidney measuring 11...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29103476/evaluation-of-fetal-kidney-growth-using-ultrasound-a-systematic-review
#2
REVIEW
Sonja Brennan, David Watson, Donna Rudd, Michal Schneider, Yogavijayan Kandasamy
PURPOSE: To determine the role of ultrasound imaging in evaluating fetal kidney growth. METHODS: MEDLINE, CINAHL and EMBASE databases were electronically searched for studies between 1996 and January 2017 and limited to English language. Studies were included if they reported on an ultrasound technique to assess fetal kidney growth and they were not a case report or case series. There was independent selection of studies by two reviewers in consensus with one other reviewer...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28838439/role-of-magnetic-resonance-elastography-as-a-noninvasive-measurement-tool-of-fibrosis-in-a-renal-allograft-a-case-report
#3
J K Kim, D A Yuen, G Leung, S Jothy, J Zaltzman, G V Ramesh Prasad, V Prabhudesai, G Mnatzakanian, A Kirpalani
A major reason for poor long-term kidney transplant outcomes is the development of chronic allograft injury, characterized by interstitial fibrosis and tubular atrophy. Currently, an invasive biopsy that samples only <1% of the kidney is the gold standard for detecting kidney allograft fibrosis. We report the use of magnetic resonance elastography (MRE) to quantify tissue stiffness as a noninvasive and whole-kidney measurement tool of allograft fibrosis in a kidney transplant patient at 2 time points. The MRE whole-kidney stiffness values reflected the changes in fibrosis of the kidney allograft as assessed by histologic examination...
September 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28736875/assessment-of-unilateral-ureter-obstruction-with-multi-parametric-mri
#4
Feng Wang, Keiko Takahashi, Hua Li, Zhongliang Zu, Ke Li, Junzhong Xu, Raymond C Harris, Takamune Takahashi, John C Gore
PURPOSE: Quantitative multi-parametric MRI (mpMRI) methods may allow the assessment of renal injury and function in a sensitive and objective manner. This study aimed to evaluate an array of MRI methods that exploit endogenous contrasts including relaxation rates, pool size ratio (PSR) derived from quantitative magnetization transfer (qMT), chemical exchange saturation transfer (CEST), nuclear Overhauser enhancement (NOE), and apparent diffusion coefficient (ADC) for their sensitivity and specificity in detecting abnormal features associated with kidney disease in a murine model of unilateral ureter obstruction (UUO)...
July 24, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28601406/kidney-function-proteinuria-and-cancer-incidence-the%C3%A2-korean%C3%A2-heart-study
#5
Yejin Mok, Kunihiro Matsushita, Shoshana H Ballew, Yingying Sang, Keum Ji Jung, Sunmi Lee, Sun Ha Jee, Josef Coresh
BACKGROUND: Reported associations of estimated glomerular filtration rate (eGFR) with cancer risk are inconsistent, and data for the proteinuria-cancer relationship are sparse. We sought to quantify the associations of cancer incidence with eGFR and with proteinuria in a large population-based cohort. STUDY DESIGN: A prospective cohort study. SETTING & PARTICIPANTS: 242,583 adults (30-74 years old) without a diagnosis of cancer at baseline in the Korean Heart Study, based on health checkups in 1996 to 2004 with follow-up until 2012...
October 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28579423/serum-phosphorus-and-risk-of-cardiovascular-disease-all-cause-mortality-or-graft-failure-in-kidney-transplant-recipients-an-ancillary-study-of-the-favorit-trial-cohort
#6
RANDOMIZED CONTROLLED TRIAL
Basma Merhi, Theresa Shireman, Myra A Carpenter, John W Kusek, Paul Jacques, Marc Pfeffer, Madhumathi Rao, Meredith C Foster, S Joseph Kim, Todd E Pesavento, Stephen R Smith, Clifton E Kew, Andrew A House, Reginald Gohh, Daniel E Weiner, Andrew S Levey, Joachim H Ix, Andrew Bostom
BACKGROUND: Mild hyperphosphatemia is a putative risk factor for cardiovascular disease [CVD], loss of kidney function, and mortality. Very limited data are available from sizable multicenter kidney transplant recipient (KTR) cohorts assessing the potential relationships between serum phosphorus levels and the development of CVD outcomes, transplant failure, or all-cause mortality. STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: The Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) Trial, a large, multicenter, multiethnic, controlled clinical trial that provided definitive evidence that high-dose vitamin B-based lowering of plasma homocysteine levels did not reduce CVD events, transplant failure, or total mortality in stable KTRs...
September 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28505627/endothelial-damage-signals-refractory-acute-kidney-injury-in-critically-ill-patients
#7
Theis S Itenov, Jens-Ulrik Jensen, Sisse R Ostrowski, Pär I Johansson, Katrin M Thormar, Jens D Lundgren, Morten H Bestle
Critically ill patients with acute kidney injury (AKI) are heterogeneous on pathophysiology and prognosis. The role of endothelial damage in the pathogenesis of refractory AKI has not been clarified. The aim was to determine if biomarkers of endothelial damage, independently of the inflammatory insult on the kidney, can predict recovery of acute kidney injury. METHODS: From the "Procalcitonin And Survival Study" multicenter intensive care unit cohort, followed for 28 days after admission, we included patients without chronic kidney disease, who survived >24 h after admission and with plasma samples at admission available for biomarker analysis...
June 2017: Shock
https://www.readbyqxmd.com/read/28398071/raman-spectroscopy-of-blood-and-blood-components
#8
Chad G Atkins, Kevin Buckley, Michael W Blades, Robin F B Turner
Blood is a bodily fluid that is vital for a number of life functions in animals. To a first approximation, blood is a mildly alkaline aqueous fluid (plasma) in which a large number of free-floating red cells (erythrocytes), white cells (leucocytes), and platelets are suspended. The primary function of blood is to transport oxygen from the lungs to all the cells of the body and move carbon dioxide in the return direction after it is produced by the cells' metabolism. Blood also carries nutrients to the cells and brings waste products to the liver and kidneys...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/27884475/frailty-kidney-function-and-polypharmacy-the%C3%A2-atherosclerosis-risk-in-communities-aric-study
#9
Shoshana H Ballew, Yan Chen, Natalie R Daya, Job G Godino, B Gwen Windham, Mara McAdams-DeMarco, Josef Coresh, Elizabeth Selvin, Morgan E Grams
BACKGROUND: Frail individuals are at increased risk for poor outcomes, including adverse drug events. Kidney function is often compromised in frailty and is a key consideration in medication choice and dosing; however, creatinine-based measures of kidney function may be biased in frail individuals. STUDY DESIGN: Observational study. SETTING & PARTICIPANTS: 4,987 community-dwelling older men and women with complete data who participated in visit 5 of the Atherosclerosis Risk in Communities (ARIC) Study (2011-2013)...
February 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27681269/an-assessment-of-urinary-biomarkers-in-a-series-of-declined-human-kidneys-measured-during-ex-vivo-normothermic-kidney-perfusion
#10
Sarah A Hosgood, Michael L Nicholson
BACKGROUND: The measurement of urinary biomarkers during ex vivo normothermic kidney perfusion (EVKP) may aid in the assessment of a kidney prior to transplantation. This study measured levels of neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) and endothelin-1 (ET-1) during EVKP in a series of discarded human kidneys. METHODS: Fifty-six kidneys from deceased donors were recruited into the study. Each kidney underwent 60 minutes of EVKP and was scored based on the macroscopic appearance, renal blood flow and urine output...
September 2017: Transplantation
https://www.readbyqxmd.com/read/27659447/research-on-pediatric-glomerular-disease-and-normal-kidney-with-shear-wave-based-elastography-point-quantification
#11
Bin Xu, Guoping Jiang, Jingjing Ye, Jin He, Wangfang Xie
PURPOSE: To evaluate the renal cortex stiffness in children with glomerular disease by shear wave based elastography point quantification (ElastPQ), and to investigate the association between shear wave velocity (SWV) in the renal cortex and age in normal children, and the inter-gender differences. MATERIALS AND METHODS: One hundred and five children who were pathologically confirmed with glomerular diseases were selected as the disease group. Meanwhile, 120 healthy children were selected as the control group...
November 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27515592/chronic-kidney-disease-and-risk-for-gastrointestinal-bleeding-in-the-community-the-atherosclerosis-risk-in-communities-aric-study
#12
Junichi Ishigami, Morgan E Grams, Rakhi P Naik, Josef Coresh, Kunihiro Matsushita
BACKGROUND AND OBJECTIVES: Patients on dialysis are known to have higher risk for gastrointestinal (GI) bleeding. However, data on mild to moderate CKD, particularly elevated albuminuria, are limited. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Among 11,088 participants in the Atherosclerosis Risk in Communities (ARIC) Study, we investigated the association of eGFR and urinary albumin-to-creatinine ratio (ACR) with risk for hospitalization with GI bleeding. Kidney measures were assessed at visit four (1996-1998), and follow-up was continued through 2011...
October 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27440086/histopathological-and-biochemical-investigations-of-protective-role-of-honey-in-rats-with-experimental-aflatoxicosis
#13
Turan Yaman, Zabit Yener, Ismail Celik
BACKGROUND: Natural honey (honey) is considered as a part of traditional medicine all over the world. It has both antimicrobial and antioxidant properties, useful in stimulation of wounds and burns healing and gastric ulcers treatment. The aim of this study, for the first time, was to investigate the antioxidant properties and protective role of honey against carcinogen chemical aflatoxin (AF) exposure in rats, which were evaluated by histopathological changes in liver and kidney, measuring level of serum marker enzymes [aspartate aminotransferase (AST), alanin aminotransferase (ALT), gamma glutamil transpeptidase (GGT)], antioxidant defense systems [Reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), glutathione-S-transferase (GST) and catalase (CAT)], and lipid peroxidation content in liver, erythrocyte, brain, kidney, heart and lungs...
July 21, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27356006/influence-of-various-living-donor-kidney-measurements-in-relation-to-recipient-body-measurements-on-posttransplant-allograft-functional-outcomes
#14
Eyup Kulah, Umit Ozcelik, Halime Cevik, Huseyin Yüce Bircan, Feza Y Karakayali
OBJECTIVES: Donor kidney measurements may affect outcomes of transplanted allografts. We tested allograft and recipient measurements on kidney allograft outcomes. In this study, we compared the effects of kidney allograft volumes, which were measured using computed tomographic angiography before transplant, and allograft weight, which was measured during surgery, in relation to the recipient's body weight and body mass index on kidney function at 6 and 12 months after transplant. MATERIAL AND METHODS: We included 74 patients (40 female and 34 male patients, mean age of 50...
June 29, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27261331/dietary-guideline-adherence-index-and-kidney-measures-in%C3%A2-the%C3%A2-framingham-heart-study
#15
Jiantao Ma, Paul F Jacques, Shih-Jen Hwang, Lisa M Troy, Nicola M McKeown, Audrey Y Chu, Caroline S Fox
BACKGROUND: No observational studies have directly considered dietary guidelines when examining the prospective association between dietary intake and kidney measures. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: We examined participants who attended examinations 7 (1998-2001) and 8 (2005-2008) in the Framingham Offspring Cohort. PREDICTORS: Individual components of Dietary Guidelines for Americans Adherence Index (DGAI) that reflect adherence to key dietary recommendations based on the 2005 guideline...
November 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27221688/direct-spontaneous-carotid-cavernous-fistula-with-a-contracted-kidney-a-rare-association
#16
Namita Kumari, Abadan Khan Amitava, Sardar Mohammed Akram, Shivani Grover
We report a case of a 20-year-old female having systemic hypertension who presented with right-sided proptosis, chemosis, and diminished vision, preceded by an acute episode of unilateral throbbing headache. Imaging studies revealed a right-sided direct, spontaneous carotid-cavernous fistula (CCF), aneurysm of internal carotid artery, bleed in the parieto-frontal lobe, and swelling of extraocular muscles. Abdominal ultrasound revealed a small contracted right kidney measuring 64 mm × 27 mm. A direct spontaneous CCF can occur spontaneously following rupture of intracranial aneurysm without any history of trauma or connective tissue disorder...
April 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27221559/use-of-computed-tomography-assessed-kidney-length-to-predict-split-renal-gfr-in-living-kidney-donors
#17
François Gaillard, Patrik Pavlov, Anne-Marie Tissier, Benoit Harache, Dominique Eladari, Marc-Olivier Timsit, Catherine Fournier, Carine Léon, Chantal Hignette, Gérard Friedlander, Jean-Michel Correas, Pierre Weinmann, Arnaud Méjean, Pascal Houillier, Christophe Legendre, Marie Courbebaisse
OBJECTIVES: Screening of living kidney donors may require scintigraphy to split glomerular filtration rate (GFR). To determine the usefulness of computed tomography (CT) to split GFR, we compared scintigraphy-split GFR to CT-split GFR. We evaluated CT-split GFR as a screening test to detect scintigraphy-split GFR lower than 40 mL/min/1.73 m(2)/kidney. METHODS: This was a monocentric retrospective study on 346 potential living donors who had GFR measurement, renal scintigraphy, and CT...
February 2017: European Radiology
https://www.readbyqxmd.com/read/27190377/aortic-stiffness-and-change-in-glomerular-filtration-rate-and-albuminuria-in-older-people
#18
Naya Huang, Meredith C Foster, Gary F Mitchell, Margret B Andresdottir, Gudny Eiriksdottir, Hrefna Gudmundsdottir, Tamara B Harris, Lenore J Launer, Runolfur Palsson, Vilmundur Gudnason, Andrew S Levey, Lesley A Inker
Background: Aortic stiffness increases with age and increases pulsatile stress in the microcirculation. Abnormalities in kidney microvascular structure and function may contribute to development or progression of chronic kidney disease in older people. Methods: We performed a longitudinal analysis of 629 community-dwelling elderly Icelandic adults from the Age, Gene/Environment Susceptibility-Reykjavik Study with two visits over a mean follow-up of 5.3 years. We evaluated the associations of carotid-femoral pulse wave velocity (CFPWV), carotid pulse pressure (CPP) and augmentation index (AI), with the change in estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) assessed as annual change and dichotomized as large changes...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27189317/association-of-mgfr-of-the-remaining-kidney-divided-by-its-volume-before-donation-with-functional-gain-in-mgfr-among-living-kidney-donors
#19
Marie Courbebaisse, François Gaillard, Anne-Marie Tissier, Catherine Fournier, Alexis Le Nestour, Jean-Michel Corréas, Hind Slimani-Thevenet, Frank Martinez, Carine Léon, Dominique Eladari, Marc-Olivier Timsit, Philippe Otal, Chantal Hignette, Gérard Friedlander, Arnaud Méjean, Pascal Houillier, Nassim Kamar, Christophe Legendre
BACKGROUND AND OBJECTIVES: The predictors of long-term renal function in living kidney donors are currently discussed. Our objectives were to describe the predictors of functional gain of the remaining kidney after kidney donation. We hypothesized that GFR of the remaining kidney divided by volume of this kidney (rk-GFR/vol) would reflect the density of functional nephrons and be inversely associated with functional gain of the remaining kidney. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a prospective monocentric study including 63 living donors (26 men; 50...
August 8, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27133437/hydroxyurea-for-treatment-of-nephrotic-syndrome-associated%C3%A2-with-polycythemia-vera
#20
Gregory L Hundemer, Ivy A Rosales, Yi-Bin Chen, Robert B Colvin, Nina E Tolkoff-Rubin
Myeloproliferative disorders are a rare cause of focal segmental glomerulosclerosis (FSGS), although the mechanism is unclear. Hydroxyurea is commonly used in these disorders for its cytoreductive properties; however, the effect of this treatment on proteinuria or kidney function remains unclear in cases of myeloproliferative disorder-associated FSGS. We describe the clinical course of a patient with polycythemia vera and nephrotic-range proteinuria, demonstrated to have FSGS on biopsy. The patient had a distant history of granulomatosis with polyangiitis (Wegener's), for which he routinely had his kidney function and proteinuria measured, allowing for early detection of nephrotic syndrome soon after being diagnosed with polycythemia vera...
September 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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