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https://www.readbyqxmd.com/read/29744748/assessing-the-kidney-function-parameters-glomerular-filtration-rate-and-effective-renal-plasma-flow-with-dynamic-fdg-pet-mri-in-healthy-subjects
#1
Barbara K Geist, Pascal Baltzer, Barbara Fueger, Martina Hamboeck, Thomas Nakuz, Laszlo Papp, Sazan Rasul, Lalith Kumar Shiyam Sundar, Marcus Hacker, Anton Staudenherz
BACKGROUND: A method was developed to assess the kidney parameters glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) from 2-deoxy-2-[18 F]fluoro-D-glucose (FDG) concentration behavior in kidneys, measured with positron emission tomography (PET) scans. Twenty-four healthy adult subjects prospectively underwent dynamic simultaneous PET/magnetic resonance imaging (MRI) examination. Time activity curves (TACs) were obtained from the dynamic PET series, with the guidance of MR information...
May 9, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29742697/giant-malignant-pheochromocytoma-in-an-elderly-patient-a-case-report
#2
Chengquan Ma, Erlin Sun, Bingxin Lu
RATIONALE: Malignant pheochromocytoma is a rare disease and surgical resection is the only curative treatment. PATIENT CONCERNS: An 81-year-old man of Chinese ethnicity was found to have a giant retroperitoneal tumor. DIAGNOSES: B-scan ultrasonography and CT scan presented a mass above the left kidney, measuring 13.5 × 10 .6 × 9.8 cm. Subsequent analysis of 24-h urinary catecholamines and vanillylmandelic acid, as well as of blood catecholamines and blood cortisol, showed no elevated levels...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29579820/correlation-of-the-renal-cortex-volume-with-the-glomerular-filtration-rate-in-live-donors-for-renal-transplantation
#3
L Garcia-Covarrubias, D R Valdéz, L A Bermudez, R Córdoba, F J Avelar, R M Villanueva, D Ortuño, J C Hernández, A García, I Castro
INTRODUCTION: As a pretransplantation evaluation, renal function is determined by the glomerular filtration rate (GFR) with the use of renal scintigraphy (RS) and the estimated glomerular filtration rate (eGFR). To date, there are few studies that correlate renal cortex volume with eGFR determined with renal gammagram (GR) and eGFR by equations (Cockroft-Gault, Modification of Diet in Renal Disease, and Chronic Kidney Disease Epidemiology Collaboration equation) in Latin American living donors...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29400364/is-there-a-correlation-between-kidney-shear-wave-velocity-measured-with-vtq-and-histological-parameters-in-patients-with-chronic-glomerulonephritis-a-pilot-study
#4
Flaviu Bob, Iulia Grosu, Ioan Sporea, Simona Bota, Alina Popescu, Roxana Sirli, Ligia Petrica, Adalbert Schiller
AIM: To analyze the relationship between shear wave velocity in the kidney measured by point shear wave elastography using Virtual Touch Quantification (VTQ) (Siemens Acuson S2000) and histological parameters obtained from renal biopsies, in patients with chronic glomerulonephritis (CGN). MATERIAL AND METHODS: The study group included 20 patients (mean age 47.95±13.59 years) with different types of CGN, that had underwent renal biopsy and 57 normal controls (mean age 38...
February 4, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29392549/acute-fissuration-of-a-giant-splenic-artery-aneurysm-detected-by-point-of-care-ultrasound-case-report
#5
Philippe Le Conte, David Trewick, Philippe Pes, Eric Frampas, Eric Batard
BACKGROUND: Epigastric pain is frequent in Emergency Medicine and remains a challenging situation. Besides benign etiologies such as gastritis or uncomplicated cholelithiasis, it could reveal myocardial infarction or vascular disease. Point-of-care ultrasound (POCUS) could be performed in such situation. CASE PRESENTATION: A healthy 66-year-old man with no previous medical history was admitted to the Emergency Department for a rapid onset epigastric pain. He reported taking non-steroidal anti-inflammatories for 1 week prior to admission...
February 1, 2018: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/29242399/novel-functional-renal-imaging-with-18-f-fds-pet-in-rat-models-of-kidney-diseases
#6
Rudolf Werner, Hiroshi Wakabayashi, Xinyu Chen, Mitsuru Hirano, Tetsuya Shinaji, Constantin Lapa, Steven P Rowe, Mehrbod S Javadi, Takahiro Higuchi
Background: Precise regional quantitative assessment of renal function is limited with conventional99m Tc-labeled renal radiotracers. A recent study reported that the positron emission tomography (PET) radiotracer 2-deoxy-2-18 F-fluorosorbitol (18 F-FDS) has ideal pharmacokinetics for functional renal imaging. Furthermore,18 F-FDS is available via simple reduction from routinely used 2-deoxy-2-18 F-fluoro-D-glucose (18 F-FDG). We aimed to further investigate the potential of18 F-FDS PET as a functional renal imaging agent using rat models of kidney diseases...
December 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29169145/early-results-on-canine-fetal-kidney-development-ultrasonographic-evaluation-and-value-in-prediction-of-delivery-time
#7
Elaine Mayumi Ueno Gil, Daniela Aparecida Ayres Garcia, Amália Turner Giannico, Tilde Rodrigues Froes
To date there have been no studies that describe the ultrasonographic evaluation of kidney development in canine fetuses. The aim of this prospective and longitudinal study was to monitor fetal kidney development with ultrasound and use fetal kidney measurements as a complementary biometric index for estimation of gestational age. Ultrasonographic examinations were performed on 15 clinically healthy pregnant bitches every four days from 30th day of pregnancy, until visualization of the fetal renal pelvis was no longer possible...
February 2018: Theriogenology
https://www.readbyqxmd.com/read/29145282/autosomal-dominant-polycystic-kidney-disease-combined-with-hypertrophic-cardiomyopathy-a-case-report
#8
REVIEW
Yingjing Shen, Chenggang Xu
INTRODUCTION: This report describes the novel sampling of autosomal dominant polycystic kidney disease (ADPKD) combined with hypertrophic cardiomyopathy (HCM). SYMPTOMS AND CLINICAL FINDINGS: A 48-year-old Chinese man presented with anasarca, hypourocrinia, gross hematuria, and weight gain by 10 kg subsequently developed acute kidney injury after struck by acute respiratory distress syndrome, really a threat to his heart. DIAGNOSES: Abdominal ultrasound revealed multiple small cysts in both kidneys, with the right kidney measuring 11...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29103476/evaluation-of-fetal-kidney-growth-using-ultrasound-a-systematic-review
#9
REVIEW
Sonja Brennan, David Watson, Donna Rudd, Michal Schneider, Yogavijayan Kandasamy
PURPOSE: To determine the role of ultrasound imaging in evaluating fetal kidney growth. METHODS: MEDLINE, CINAHL and EMBASE databases were electronically searched for studies between 1996 and January 2017 and limited to English language. Studies were included if they reported on an ultrasound technique to assess fetal kidney growth and they were not a case report or case series. There was independent selection of studies by two reviewers in consensus with one other reviewer...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28838439/role-of-magnetic-resonance-elastography-as-a-noninvasive-measurement-tool-of-fibrosis-in-a-renal-allograft-a-case-report
#10
J K Kim, D A Yuen, G Leung, S Jothy, J Zaltzman, G V Ramesh Prasad, V Prabhudesai, G Mnatzakanian, A Kirpalani
A major reason for poor long-term kidney transplant outcomes is the development of chronic allograft injury, characterized by interstitial fibrosis and tubular atrophy. Currently, an invasive biopsy that samples only <1% of the kidney is the gold standard for detecting kidney allograft fibrosis. We report the use of magnetic resonance elastography (MRE) to quantify tissue stiffness as a noninvasive and whole-kidney measurement tool of allograft fibrosis in a kidney transplant patient at 2 time points. The MRE whole-kidney stiffness values reflected the changes in fibrosis of the kidney allograft as assessed by histologic examination...
September 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28736875/assessment-of-unilateral-ureter-obstruction-with-multi-parametric-mri
#11
Feng Wang, Keiko Takahashi, Hua Li, Zhongliang Zu, Ke Li, Junzhong Xu, Raymond C Harris, Takamune Takahashi, John C Gore
PURPOSE: Quantitative multi-parametric MRI (mpMRI) methods may allow the assessment of renal injury and function in a sensitive and objective manner. This study aimed to evaluate an array of MRI methods that exploit endogenous contrasts including relaxation rates, pool size ratio (PSR) derived from quantitative magnetization transfer (qMT), chemical exchange saturation transfer (CEST), nuclear Overhauser enhancement (NOE), and apparent diffusion coefficient (ADC) for their sensitivity and specificity in detecting abnormal features associated with kidney disease in a murine model of unilateral ureter obstruction (UUO)...
April 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28601406/kidney-function-proteinuria-and-cancer-incidence-the-korean-heart-study
#12
Yejin Mok, Kunihiro Matsushita, Shoshana H Ballew, Yingying Sang, Keum Ji Jung, Sunmi Lee, Sun Ha Jee, Josef Coresh
BACKGROUND: Reported associations of estimated glomerular filtration rate (eGFR) with cancer risk are inconsistent, and data for the proteinuria-cancer relationship are sparse. We sought to quantify the associations of cancer incidence with eGFR and with proteinuria in a large population-based cohort. STUDY DESIGN: A prospective cohort study. SETTING & PARTICIPANTS: 242,583 adults (30-74 years old) without a diagnosis of cancer at baseline in the Korean Heart Study, based on health checkups in 1996 to 2004 with follow-up until 2012...
October 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28579423/serum-phosphorus-and-risk-of-cardiovascular-disease-all-cause-mortality-or-graft-failure-in-kidney-transplant-recipients-an-ancillary-study-of-the-favorit-trial-cohort
#13
RANDOMIZED CONTROLLED TRIAL
Basma Merhi, Theresa Shireman, Myra A Carpenter, John W Kusek, Paul Jacques, Marc Pfeffer, Madhumathi Rao, Meredith C Foster, S Joseph Kim, Todd E Pesavento, Stephen R Smith, Clifton E Kew, Andrew A House, Reginald Gohh, Daniel E Weiner, Andrew S Levey, Joachim H Ix, Andrew Bostom
BACKGROUND: Mild hyperphosphatemia is a putative risk factor for cardiovascular disease [CVD], loss of kidney function, and mortality. Very limited data are available from sizable multicenter kidney transplant recipient (KTR) cohorts assessing the potential relationships between serum phosphorus levels and the development of CVD outcomes, transplant failure, or all-cause mortality. STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: The Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) Trial, a large, multicenter, multiethnic, controlled clinical trial that provided definitive evidence that high-dose vitamin B-based lowering of plasma homocysteine levels did not reduce CVD events, transplant failure, or total mortality in stable KTRs...
September 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28505627/endothelial-damage-signals-refractory-acute-kidney-injury-in-critically-ill-patients
#14
MULTICENTER STUDY
Theis S Itenov, Jens-Ulrik Jensen, Sisse R Ostrowski, Pär I Johansson, Katrin M Thormar, Jens D Lundgren, Morten H Bestle
Critically ill patients with acute kidney injury (AKI) are heterogeneous on pathophysiology and prognosis. The role of endothelial damage in the pathogenesis of refractory AKI has not been clarified. The aim was to determine if biomarkers of endothelial damage, independently of the inflammatory insult on the kidney, can predict recovery of acute kidney injury. METHODS: From the "Procalcitonin And Survival Study" multicenter intensive care unit cohort, followed for 28 days after admission, we included patients without chronic kidney disease, who survived >24 h after admission and with plasma samples at admission available for biomarker analysis...
June 2017: Shock
https://www.readbyqxmd.com/read/28398071/raman-spectroscopy-of-blood-and-blood-components
#15
Chad G Atkins, Kevin Buckley, Michael W Blades, Robin F B Turner
Blood is a bodily fluid that is vital for a number of life functions in animals. To a first approximation, blood is a mildly alkaline aqueous fluid (plasma) in which a large number of free-floating red cells (erythrocytes), white cells (leucocytes), and platelets are suspended. The primary function of blood is to transport oxygen from the lungs to all the cells of the body and move carbon dioxide in the return direction after it is produced by the cells' metabolism. Blood also carries nutrients to the cells and brings waste products to the liver and kidneys...
May 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/27884475/frailty-kidney-function-and-polypharmacy-the-atherosclerosis-risk-in-communities-aric-study
#16
Shoshana H Ballew, Yan Chen, Natalie R Daya, Job G Godino, B Gwen Windham, Mara McAdams-DeMarco, Josef Coresh, Elizabeth Selvin, Morgan E Grams
BACKGROUND: Frail individuals are at increased risk for poor outcomes, including adverse drug events. Kidney function is often compromised in frailty and is a key consideration in medication choice and dosing; however, creatinine-based measures of kidney function may be biased in frail individuals. STUDY DESIGN: Observational study. SETTING & PARTICIPANTS: 4,987 community-dwelling older men and women with complete data who participated in visit 5 of the Atherosclerosis Risk in Communities (ARIC) Study (2011-2013)...
February 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27681269/an-assessment-of-urinary-biomarkers-in-a-series-of-declined-human-kidneys-measured-during-ex-vivo-normothermic-kidney-perfusion
#17
Sarah A Hosgood, Michael L Nicholson
BACKGROUND: The measurement of urinary biomarkers during ex vivo normothermic kidney perfusion (EVKP) may aid in the assessment of a kidney prior to transplantation. This study measured levels of neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) and endothelin-1 (ET-1) during EVKP in a series of discarded human kidneys. METHODS: Fifty-six kidneys from deceased donors were recruited into the study. Each kidney underwent 60 minutes of EVKP and was scored based on the macroscopic appearance, renal blood flow and urine output...
September 2017: Transplantation
https://www.readbyqxmd.com/read/27659447/research-on-pediatric-glomerular-disease-and-normal-kidney-with-shear-wave-based-elastography-point-quantification
#18
Bin Xu, Guoping Jiang, Jingjing Ye, Jin He, Wangfang Xie
PURPOSE: To evaluate the renal cortex stiffness in children with glomerular disease by shear wave based elastography point quantification (ElastPQ), and to investigate the association between shear wave velocity (SWV) in the renal cortex and age in normal children, and the inter-gender differences. MATERIALS AND METHODS: One hundred and five children who were pathologically confirmed with glomerular diseases were selected as the disease group. Meanwhile, 120 healthy children were selected as the control group...
November 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27515592/chronic-kidney-disease-and-risk-for-gastrointestinal-bleeding-in-the-community-the-atherosclerosis-risk-in-communities-aric-study
#19
Junichi Ishigami, Morgan E Grams, Rakhi P Naik, Josef Coresh, Kunihiro Matsushita
BACKGROUND AND OBJECTIVES: Patients on dialysis are known to have higher risk for gastrointestinal (GI) bleeding. However, data on mild to moderate CKD, particularly elevated albuminuria, are limited. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Among 11,088 participants in the Atherosclerosis Risk in Communities (ARIC) Study, we investigated the association of eGFR and urinary albumin-to-creatinine ratio (ACR) with risk for hospitalization with GI bleeding...
October 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27440086/histopathological-and-biochemical-investigations-of-protective-role-of-honey-in-rats-with-experimental-aflatoxicosis
#20
Turan Yaman, Zabit Yener, Ismail Celik
BACKGROUND: Natural honey (honey) is considered as a part of traditional medicine all over the world. It has both antimicrobial and antioxidant properties, useful in stimulation of wounds and burns healing and gastric ulcers treatment. The aim of this study, for the first time, was to investigate the antioxidant properties and protective role of honey against carcinogen chemical aflatoxin (AF) exposure in rats, which were evaluated by histopathological changes in liver and kidney, measuring level of serum marker enzymes [aspartate aminotransferase (AST), alanin aminotransferase (ALT), gamma glutamil transpeptidase (GGT)], antioxidant defense systems [Reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), glutathione-S-transferase (GST) and catalase (CAT)], and lipid peroxidation content in liver, erythrocyte, brain, kidney, heart and lungs...
July 21, 2016: BMC Complementary and Alternative Medicine
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