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"Kidney measure"

Shoshana H Ballew, Yan Chen, Natalie R Daya, Job G Godino, B Gwen Windham, Mara McAdams-DeMarco, Josef Coresh, Elizabeth Selvin, Morgan E Grams
BACKGROUND: Frail individuals are at increased risk for poor outcomes, including adverse drug events. Kidney function is often compromised in frailty and is a key consideration in medication choice and dosing; however, creatinine-based measures of kidney function may be biased in frail individuals. STUDY DESIGN: Observational study. SETTING & PARTICIPANTS: 4,987 community-dwelling older men and women with complete data who participated in visit 5 of the Atherosclerosis Risk in Communities (ARIC) Study (2011-2013)...
February 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Sarah A Hosgood, Michael L Nicholson
BACKGROUND: The measurement of urinary biomarkers during ex-vivo normothermic kidney perfusion (EVKP) may aid in the assessment of a kidney prior to transplantation. This study measured levels of neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) and endothelin-1 (ET-1) during EVKP in a series of discarded human kidneys. METHODS: Fifty six kidneys from deceased donors were recruited into the study. Each kidney underwent 60 minutes of EVKP and was scored based on the macroscopic appearance, renal blood flow and urine output...
September 27, 2016: Transplantation
Bin Xu, Guoping Jiang, Jingjing Ye, Jin He, Wangfang Xie
PURPOSE: To evaluate the renal cortex stiffness in children with glomerular disease by shear wave based elastography point quantification (ElastPQ), and to investigate the association between shear wave velocity (SWV) in the renal cortex and age in normal children, and the inter-gender differences. MATERIALS AND METHODS: One hundred and five children who were pathologically confirmed with glomerular diseases were selected as the disease group. Meanwhile, 120 healthy children were selected as the control group...
November 2016: Japanese Journal of Radiology
Junichi Ishigami, Morgan E Grams, Rakhi P Naik, Josef Coresh, Kunihiro Matsushita
BACKGROUND AND OBJECTIVES: Patients on dialysis are known to have higher risk for gastrointestinal (GI) bleeding. However, data on mild to moderate CKD, particularly elevated albuminuria, are limited. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Among 11,088 participants in the Atherosclerosis Risk in Communities (ARIC) Study, we investigated the association of eGFR and urinary albumin-to-creatinine ratio (ACR) with risk for hospitalization with GI bleeding. Kidney measures were assessed at visit four (1996-1998), and follow-up was continued through 2011...
August 11, 2016: Clinical Journal of the American Society of Nephrology: CJASN
Turan Yaman, Zabit Yener, Ismail Celik
BACKGROUND: Natural honey (honey) is considered as a part of traditional medicine all over the world. It has both antimicrobial and antioxidant properties, useful in stimulation of wounds and burns healing and gastric ulcers treatment. The aim of this study, for the first time, was to investigate the antioxidant properties and protective role of honey against carcinogen chemical aflatoxin (AF) exposure in rats, which were evaluated by histopathological changes in liver and kidney, measuring level of serum marker enzymes [aspartate aminotransferase (AST), alanin aminotransferase (ALT), gamma glutamil transpeptidase (GGT)], antioxidant defense systems [Reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), glutathione-S-transferase (GST) and catalase (CAT)], and lipid peroxidation content in liver, erythrocyte, brain, kidney, heart and lungs...
July 21, 2016: BMC Complementary and Alternative Medicine
Eyup Kulah, Umit Ozcelik, Halime Cevik, Huseyin Yüce Bircan, Feza Y Karakayali
OBJECTIVES: Donor kidney measurements may affect outcomes of transplanted allografts. We tested allograft and recipient measurements on kidney allograft outcomes. In this study, we compared the effects of kidney allograft volumes, which were measured using computed tomographic angiography before transplant, and allograft weight, which was measured during surgery, in relation to the recipient's body weight and body mass index on kidney function at 6 and 12 months after transplant. MATERIAL AND METHODS: We included 74 patients (40 female and 34 male patients, mean age of 50...
June 29, 2016: Experimental and Clinical Transplantation
Jiantao Ma, Paul F Jacques, Shih-Jen Hwang, Lisa M Troy, Nicola M McKeown, Audrey Y Chu, Caroline S Fox
BACKGROUND: No observational studies have directly considered dietary guidelines when examining the prospective association between dietary intake and kidney measures. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: We examined participants who attended examinations 7 (1998-2001) and 8 (2005-2008) in the Framingham Offspring Cohort. PREDICTORS: Individual components of Dietary Guidelines for Americans Adherence Index (DGAI) that reflect adherence to key dietary recommendations based on the 2005 guideline...
November 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Namita Kumari, Abadan Khan Amitava, Sardar Mohammed Akram, Shivani Grover
We report a case of a 20-year-old female having systemic hypertension who presented with right-sided proptosis, chemosis, and diminished vision, preceded by an acute episode of unilateral throbbing headache. Imaging studies revealed a right-sided direct, spontaneous carotid-cavernous fistula (CCF), aneurysm of internal carotid artery, bleed in the parieto-frontal lobe, and swelling of extraocular muscles. Abdominal ultrasound revealed a small contracted right kidney measuring 64 mm × 27 mm. A direct spontaneous CCF can occur spontaneously following rupture of intracranial aneurysm without any history of trauma or connective tissue disorder...
April 2016: Indian Journal of Ophthalmology
François Gaillard, Patrik Pavlov, Anne-Marie Tissier, Benoit Harache, Dominique Eladari, Marc-Olivier Timsit, Catherine Fournier, Carine Léon, Chantal Hignette, Gérard Friedlander, Jean-Michel Correas, Pierre Weinmann, Arnaud Méjean, Pascal Houillier, Christophe Legendre, Marie Courbebaisse
OBJECTIVES: Screening of living kidney donors may require scintigraphy to split glomerular filtration rate (GFR). To determine the usefulness of computed tomography (CT) to split GFR, we compared scintigraphy-split GFR to CT-split GFR. We evaluated CT-split GFR as a screening test to detect scintigraphy-split GFR lower than 40 mL/min/1.73 m(2)/kidney. METHODS: This was a monocentric retrospective study on 346 potential living donors who had GFR measurement, renal scintigraphy, and CT...
February 2017: European Radiology
Naya Huang, Meredith C Foster, Gary F Mitchell, Margret B Andresdottir, Gudny Eiriksdottir, Hrefna Gudmundsdottir, Tamara B Harris, Lenore J Launer, Runolfur Palsson, Vilmundur Gudnason, Andrew S Levey, Lesley A Inker
BACKGROUND: Aortic stiffness increases with age and increases pulsatile stress in the microcirculation. Abnormalities in kidney microvascular structure and function may contribute to development or progression of chronic kidney disease in older people. METHODS: We performed a longitudinal analysis of 629 community-dwelling elderly Icelandic adults from the Age, Gene/Environment Susceptibility-Reykjavik Study with two visits over a mean follow-up of 5.3 years. We evaluated the associations of carotid-femoral pulse wave velocity (CFPWV), carotid pulse pressure (CPP) and augmentation index (AI), with the change in estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) assessed as annual change and dichotomized as large changes...
March 28, 2016: Nephrology, Dialysis, Transplantation
Marie Courbebaisse, François Gaillard, Anne-Marie Tissier, Catherine Fournier, Alexis Le Nestour, Jean-Michel Corréas, Hind Slimani-Thevenet, Frank Martinez, Carine Léon, Dominique Eladari, Marc-Olivier Timsit, Philippe Otal, Chantal Hignette, Gérard Friedlander, Arnaud Méjean, Pascal Houillier, Nassim Kamar, Christophe Legendre
BACKGROUND AND OBJECTIVES: The predictors of long-term renal function in living kidney donors are currently discussed. Our objectives were to describe the predictors of functional gain of the remaining kidney after kidney donation. We hypothesized that GFR of the remaining kidney divided by volume of this kidney (rk-GFR/vol) would reflect the density of functional nephrons and be inversely associated with functional gain of the remaining kidney. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a prospective monocentric study including 63 living donors (26 men; 50...
August 8, 2016: Clinical Journal of the American Society of Nephrology: CJASN
Gregory L Hundemer, Ivy A Rosales, Yi-Bin Chen, Robert B Colvin, Nina E Tolkoff-Rubin
Myeloproliferative disorders are a rare cause of focal segmental glomerulosclerosis (FSGS), although the mechanism is unclear. Hydroxyurea is commonly used in these disorders for its cytoreductive properties; however, the effect of this treatment on proteinuria or kidney function remains unclear in cases of myeloproliferative disorder-associated FSGS. We describe the clinical course of a patient with polycythemia vera and nephrotic-range proteinuria, demonstrated to have FSGS on biopsy. The patient had a distant history of granulomatosis with polyangiitis (Wegener's), for which he routinely had his kidney function and proteinuria measured, allowing for early detection of nephrotic syndrome soon after being diagnosed with polycythemia vera...
September 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Matthias Hammon, Rolf Janka, Christian Siegl, Hannes Seuss, Roberto Grosso, Petros Martirosian, Roland E Schmieder, Michael Uder, Iris Kistner
Magnetic resonance imaging with arterial spin labeling (ASL) is a noninvasive approach to measure organ perfusion. The purpose of this study was to evaluate the reproducibility of ASL kidney perfusion measurements with semiautomatic segmentation, which allows separate quantification of cortical and medullary perfusion. The right kidneys of 14 healthy volunteers were examined 6 times on 2 occasions (3 times at each occasion). There was a 10-minute pause between each examination and a 14-day interval between the 2 occasions...
March 2016: Medicine (Baltimore)
Kozeta Miliku, Suzanne Vogelezang, Oscar H Franco, Albert Hofman, Vincent W V Jaddoe, Janine F Felix
BACKGROUND: Kidney measures in early life are associated with kidney disease in later life. We hypothesized that these associations are partly explained by common genetic variants that lead to both smaller kidneys with lower kidney function in early childhood and kidney disease in adulthood. METHODS: We examined in a population-based prospective cohort study among 4,119 children the associations of a weighted genetic risk score combining 20 previously identified common genetic variants related to adult eGFRcreat with kidney outcomes in children aged 6...
2016: Pediatric Research
A Uyar, Z Yener, A Dogan
The ameliorative potential and antioxidant capacity of an extract of Urtica dioica seeds (UDS) was investigated using histopathological changes in liver and kidney, measuring serum marker enzymes, antioxidant defence systems and lipid peroxidation (malondialdehyde (MDA)) content in various tissues of broilers exposed to aflatoxin (AF). A total of 32 broilers were divided randomly into 4 groups: control, UDS extract-treated, AF-treated and AF+UDS extract-treated. Broilers in control and UDS extract-treated groups were fed on a diet without AF...
April 2016: British Poultry Science
Daniela Dunkler, Maria Kohl, Koon K Teo, Georg Heinze, Mahshid Dehghan, Catherine M Clase, Peggy Gao, Salim Yusuf, Johannes F E Mann, Rainer Oberbauer
BACKGROUND: We quantified the impact of lifestyle and dietary modifications on chronic kidney disease (CKD) by estimating population-attributable fractions (PAFs). STUDY DESIGN: Observational cohort study. SETTING & PARTICIPANTS: Middle-aged adults with type 2 diabetes but without severe albuminuria from the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial (ONTARGET; n=6,916). FACTORS: Modifiable lifestyle/dietary risk factors, such as physical activity, size of social network, alcohol intake, tobacco use, diet, and intake of various food items...
July 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
V Yw Guo, S Brage, U Ekelund, S J Griffin, R K Simmons
AIM: To assess the prospective association between objectively measured physical activity and kidney function over 4 years in people with Type 2 diabetes. METHODS: Individuals (120 women and 206 men) participating in the ADDITION-Plus trial underwent assessment of sedentary time (SED-time), time spent in moderate-to-vigorous-intensity physical activity (MVPA) and total physical activity energy expenditure (PAEE) using a combined heart rate and movement sensor, and kidney function [estimated glomerular filtration rate (eGFR), serum creatinine and urine albumin-to-creatinine ratio (ACR)] at baseline and after 4 years of follow-up...
September 2016: Diabetic Medicine: a Journal of the British Diabetic Association
Paul J Roderick, Robin F Jeffrey, Ho M Yuen, Keith M Godfrey, Jane West, John Wright
BACKGROUND: Rates of advanced chronic kidney disease and renal replacement therapy are higher in South Asian than in white British populations. Low birth weight is also more frequent in South Asian populations and has been associated with increased risks of kidney disease, perhaps due to a reduced nephron endowment. METHODS: Using ultrasound scans at 34 weeks of gestation, we measured fetal kidney dimensions (transverse and anteroposterior diameters, length and circumference) and derived volume in a random sample of 872 white British and 715 South Asian participants in the Born in Bradford cohort study...
March 2016: Nephrology, Dialysis, Transplantation
Nadine Alexander, Kunihiro Matsushita, Yingying Sang, Shoshana Ballew, Bakhtawar K Mahmoodi, Brad C Astor, Josef Coresh
BACKGROUND: Whether the association of chronic kidney disease (CKD) with cardiovascular risk differs based on diabetes mellitus (DM) and hypertension (HTN) status remains unanswered. METHODS: We investigated 11,050 participants from the Atherosclerosis Risk in Communities Study (fourth examination (1996-1998)) with follow-up for cardiovascular outcomes (coronary disease, heart failure and stroke) through 2009. Using the Cox regression models, we quantified cardiovascular risk associated with estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR) in individuals with and without DM and/or HTN and assessed their interactions...
2015: American Journal of Nephrology
Rita C Cavaglieri, Robert T Day, Denis Feliers, Hanna E Abboud
Unilateral ureteral obstruction causes important tubulo-interstitial fibrosis in the kidney. Metformin reduces fibrosis in mice with diabetic nephropathy. We examined the effects of metformin in a mouse model of unilateral ureteral obstruction (UUO). Expression of inflammation and fibrosis markers was studied by immunohistochemistry, immunoblot and quantitative real-time polymerase chain reaction. Seven days after UUO, kidneys presented dilated tubules, expansion of the tubulo-interstitial compartment, and significant infiltration of inflammatory cells...
September 5, 2015: Molecular and Cellular Endocrinology
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