keyword
https://read.qxmd.com/read/38483456/ai-as-a-medical-device-for-ophthalmic-imaging-in-europe-australia-and-the-united-states-protocol-for-a-systematic-scoping-review-of-regulated-devices
#21
JOURNAL ARTICLE
Ariel Yuhan Ong, Henry David Jeffry Hogg, Aditya U Kale, Priyal Taribagil, Ashley Kras, Eliot Dow, Trystan Macdonald, Xiaoxuan Liu, Pearse A Keane, Alastair K Denniston
BACKGROUND: Artificial intelligence as a medical device (AIaMD) has the potential to transform many aspects of ophthalmic care, such as improving accuracy and speed of diagnosis, addressing capacity issues in high-volume areas such as screening, and detecting novel biomarkers of systemic disease in the eye (oculomics). In order to ensure that such tools are safe for the target population and achieve their intended purpose, it is important that these AIaMD have adequate clinical evaluation to support any regulatory decision...
March 14, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38483364/clinical-grade-human-embryonic-stem-cell-derived-mesenchymal-stromal-cells-ameliorate-diabetic-retinopathy-in-db-db-mice
#22
JOURNAL ARTICLE
Liyuan Rong, Wumei Wei, Yifan Fang, Yanchen Liu, Tingting Gao, Liu Wang, Jie Hao, Xianliang Gu, Jun Wu, Wei Wu
BACKGROUND AIMS: Mesenchymal stromal cells (MSCs) hold great promise in the treatment of diabetic retinopathy (DR), as evidenced by increasing preclinical and clinical studies. However, the absence of standardized and industrialized clinical-grade donor cells hampers the continued development and large-scale clinical application of MSCs-based therapies for DR. Previously, we have identified a unique population of MSCs generated from a clinical-grade human embryonic stem cell (hESC) line under Good Manufacturing Practice conditions that could be a potential source to address the issues...
March 4, 2024: Cytotherapy
https://read.qxmd.com/read/38483359/good-manufacturing-practice-compliant-human-induced-pluripotent-stem-cells-from-bench-to-putative-clinical-products
#23
JOURNAL ARTICLE
Juan J Novoa, Inge M Westra, Esther Steeneveld, Natascha Fonseca Neves, Christiaan H Arendzen, Bahareh Rajaei, Esmée Grundeken, Mehmet Yildiz, Wouter van der Valk, Alison Salvador, Françoise Carlotti, Pascale F Dijkers, Heiko Locher, Cathelijne W van den Berg, Karine I Raymond, Agnete Kirkeby, Christine L Mummery, Ton J Rabelink, Christian Freund, Pauline Meij, Brigitte Wieles
BACKGROUND AIMS: Few human induced pluripotent stem cell (hiPSC) lines are Good Manufacturing Practice (GMP)-compliant, limiting the clinical use of hiPSC-derived products. Here, we addressed this by establishing and validating an in-house platform to produce GMP-compliant hiPSCs that would be appropriate for producing both allogeneic and autologous hiPSC-derived products. METHODS: Our standard research protocol for hiPSCs production was adapted and translated into a GMP-compliant platform...
March 5, 2024: Cytotherapy
https://read.qxmd.com/read/38483157/integrated-electrochemical-aptasensor-array-toward-monitoring-anticancer-drugs-in-sweat
#24
JOURNAL ARTICLE
Xiaoyu Zhang, Jiabing Zhang, Ying Cai, Siting Xu, Hao Wu, Xiangyu Chen, Yu Huang, Fengyu Li
In the realm of clinical practice, the concurrent utilization of anticancer medications can enhance their overall therapeutic efficacy. However, it is crucial to acknowledge that the interactions among these anticancer drugs can potentially yield detrimental consequences on their intended outcomes. Consequently, the assessment of both anticancer potency and potential toxic side effects is greatly refined when multiple anticancer drugs are simultaneously detected and evaluated. Here, we designed a wearable electrochemical aptasensor array for monitoring multiple anticancer drugs in sweat...
March 14, 2024: Analytical Chemistry
https://read.qxmd.com/read/38482898/real-world-effectiveness-and-safety-of-bimekizumab-in-japanese-patients-with-psoriasis-a-single-center-retrospective-study
#25
JOURNAL ARTICLE
Teppei Hagino, Hidehisa Saeki, Eita Fujimoto, Naoko Kanda
Bimekizumab, which suppresses both interleukin (IL)-17A and IL-17F, has recently been approved as a biologic for psoriasis. We aimed to evaluate the real-world effectiveness and safety of bimekizumab for psoriasis and to identify predictive factors for its treatment responsiveness. We analyzed 36 Japanese patients with psoriasis (19 with psoriasis vulgaris and 17 with psoriatic arthritis) from May 2022 to September 2023. All patients received bimekizumab (320 mg every 4 weeks) until week 16. Seventeen patients (43...
March 14, 2024: Journal of Dermatology
https://read.qxmd.com/read/38482240/the-efficacy-associated-biomarkers-for-immune-checkpoint-inhibitors-in-gastrointestinal-cancer-a-literature-review
#26
REVIEW
Peixi Zhao, Rui Jin, Bin Zhao, Le Han, Wenjuan Chen, Nina Hao, Yi Cui, Ankit Madan, Joy Awosika, Shane Lloyd, Yili Zhang
BACKGROUND AND OBJECTIVE: Immune checkpoint inhibitors (ICIs) have been widely applied and studied in the treatment of gastrointestinal (GI) cancers, and have achieved good results. However, in clinical practice, it has been observed that only some patients respond well to ICIs, and some patients may experience various degrees of adverse reactions during the treatment. Timely evaluation of the potential therapeutic effects and adverse reactions of ICIs for patients has important clinical significance...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38481741/a-post-authorization-safety-surveillance-study-to-report-clinical-experience-with-purified-factor-ix-concentrate-in-pediatric-patients-with-hemophilia-b
#27
JOURNAL ARTICLE
Zoran Igrutinović, Hélène Louise Hooimeijer, Karim Kentouche, Jaco Botha, Peter L Turecek, Marta Kokot-Kierepa, Hanna T Gazda
INTRODUCTION: Purified factor IX (FIX) concentrate (IMMUNINE® , Takeda Manufacturing Austria AG, Vienna, Austria) is indicated for the treatment and prophylaxis of bleeding episodes in patients with congenital hemophilia B. Data on the use of purified FIX concentrate in patients ≤6 years old with congenital hemophilia B are limited. AIM: Document real-world clinical experience with purified FIX concentrate in routine practice for pediatric patients with hemophilia B...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38481537/self-care-practices-and-the-associated-socio-demographic-variables-of-persons-with-type-2-diabetes-mellitus-t2dm-in-southeast-nigeria
#28
JOURNAL ARTICLE
Christiana Nkiru Okafor, Uchenna Prosper Okonkwo, Kenneth Umezulike Ani, Ethel Ogoemeka Onuora, Mathew Nwokike, Jane Turyasingura Byabagambi, Munezero Tamu JohnBosco, Valence Mfitumukiza, Mercy Chinenye Nwankwo, Alex Tumusiime
OBJECTIVE: The study was aimed at assessing the self-care practices and the associated socio-demographic variables of persons with T2DM in South East, Nigeria. METHODOLOGY: A cross-sectional study involving 382 persons with T2DM proportionately selected from 4 tertiary health institutions in South Eastern, Nigeria. Data was collected using the Summary of Diabetes Self-Care Activities (SDSCA) and a researcher-developed questionnaire. The questionnaire was administered to persons with T2DM who attended a diabetic outpatient clinic...
2024: Nutrition and Metabolic Insights
https://read.qxmd.com/read/38481393/intern-nursing-students-knowledge-of-vascular-catheter-associated-infections-and-its-associated-factors-a-cross-sectional-survey-in-china
#29
JOURNAL ARTICLE
Jiaji Hu, Binbin Xu, Nian Yao, Sha Peng, Ran Xu, Guiyuan Ma, Jinghui Zhang
BACKGROUND: Medical personnel contact with the patient closely, and their knowledge of vascular catheter-associated infections (VCAIs) is closely related to the prevention of VCAIs. Researchers mainly pay attention to the VCAIs knowledge of doctors and nurses but rarely pay attention to the nursing students in the hospital internship stage. PURPOSE: To investigate the current situation of knowledge of intern-nursing students in VCAIs, and analyze its influencing factors...
2024: Risk Management and Healthcare Policy
https://read.qxmd.com/read/38481092/children-s-and-parents-experiences-of-home-care-provided-by-hospital-staff-a-scoping-review
#30
REVIEW
Elisabeth Grov Beisland, Jorunn Drageset, Mari Gaupås Blindheim, Gøril Tvedten Jorem, Asgjerd Litleré Moi
AIMS: To describe what is known from existing scientific literature on children's and parents' experiences of hospital-based home care and to identify future research areas. DESIGN: The scoping review design used adheres to the methodological framework of Arksey and O'Malley, and to the PRISMA-ScR checklist. REVIEW METHODS: A systematic search was conducted, and peer-reviewed scientific papers were screened through the application of Rayyan software...
March 13, 2024: Journal of Clinical Nursing
https://read.qxmd.com/read/38481054/scalable-and-versatile-metal-ion-solidificated-alginate-hydrogel-for-skin-wound-infection-therapy
#31
JOURNAL ARTICLE
By Haomiao Zhang, Ye Lu, Lei Huang, Ping Liu, Jun Ni, Tianqi Yang, Yihong Li, Yu Zhong, Xinping He, Xinhui Xia, Jiancang Zhou
Bacterial infections in wounds continue to be a major challenge in clinical settings worldwide and represent a significant threat to human health. In this work, we have proposed novel expandable and versatile methods for solidifying sodium alginate (SA) with metal ions (such as Fe3+ , Co2+ , Ni2+ , Cu2+ , and Zn2+ ) to create Metal-Alginate (M-Alg) hydrogel with adjustable morphology, composition, and microstructure. It conforms to the wound site, protects against second infection, reduces inflammation, and promotes the healing of infected wounds...
March 13, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38480770/a-risk-prediction-nomogram-for-resistant-hypertension-in-patients-with-obstructive-sleep-apnea
#32
JOURNAL ARTICLE
Hongze Lin, Chen Zhou, Jiaying Li, Xiuqin Ma, Yan Yang, Taofeng Zhu
Patients with obstructive sleep apnea (OSA) are liable to have resistant hypertension (RH) associated with unfavorable cardiovascular events. It is of necessity to predict OSA patients who are susceptible to resistant hypertension. Hence, we conducted a retrospective study based on the clinical records of OSA patients admitted to Yixing Hospital Affiliated to Jiangsu University from January 2018 to December 2022. According to different time periods, patients diagnosed between January 2018 and December 2021 were included in the training set (n = 539) for modeling, and those diagnosed between January 2022 and December 2022 were enrolled into the validation set (n = 259) for further assessment...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38479614/prospective-validation-of-the-easl-management-algorithm-for-acute-kidney-injury-in-cirrhosis
#33
JOURNAL ARTICLE
Ann Thu Ma, Cristina Solé, Adrià Juanola, Laia Escudé, Laura Napoleone, Emma Avitabile, Martina Pérez-Guasch, Marta Carol, Enrico Pompili, Jordi Gratacós-Ginés, Anna Soria, Ana Belén Rubio, Marta Cervera, Maria José Moreta, Manuel Morales, Elsa Solà, Esteban Poch, Núria Fabrellas, Isabel Graupera, Elisa Pose, Pere Ginès
BACKGROUND AND AIMS: The management of acute kidney injury (AKI) in cirrhosis is challenging. The EASL guidelines proposed an algorithm, but this has never been validated. We aimed to prospectively evaluate this algorithm in clinical practice. METHODS: Prospective cohort study of consecutive hospitalized patients with cirrhosis and AKI. EASL management algorithm includes identification/treatment of precipitating factors, 2-day albumin infusion in patients with AKI ≥ stage 1B, and treatment with terlipressin in patients with hepatorenal syndrome (HRS-AKI)...
March 11, 2024: Journal of Hepatology
https://read.qxmd.com/read/38479448/accuracy-of-intermittently-scanned-continuous-glucose-monitoring-during-caesarean-delivery-in-pregnant-women-with-insulin-treated-diabetes
#34
JOURNAL ARTICLE
Fabrizia Citro, Cristina Bianchi, Michele Aragona, Tommaso Belcari, Lorella Battini, Piero Marchetti, Alessandra Bertolotto
AIM: Continuous Glucose Monitoring (CGM) systems are not currently recommended to guide intrapartum glucose and insulin infusion, due to insufficient data. In this study, intrapartum accuracy of intermittently scanned CGM (isCGM), compared to simultaneously measured capillary glucose (CG), was evaluated. METHODS: Paired isCGM (Freestyle Libre 2) - CG data during caesarean delivery in pregnant women with insulin-treated diabetes were prospectively collected. The isCGM accuracy was assessed by MARD and Clarke Error Grid analysis...
March 11, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38479252/non-pharmacological-and-pharmacological-treatments-for-bone-health-after-stroke-systematic-review-with-meta-analysis
#35
REVIEW
Huixi Ouyang, Tsun C Lee, Faye Yf Chan, Xun Li, King Y Lai, Wing Y Lam, Tsz Y Yung, Marco Y C Pang
BACKGROUND: Hemi-osteoporosis is a common secondary complication of stroke. No systematic reviews of pharmacological and non-pharmacological agents for post-stroke bone health have estimated the magnitude and precision of effect sizes to guide better clinical practice. OBJECTIVES: To examine the benefits and harms of pharmacological and non-pharmacological agents on bone health in post-stroke individuals. METHODS: Eight databases were searched (PubMed, Cochrane library, Scopus, CINAHL Complete, Embase, PEDro, Clinicaltrils...
March 12, 2024: Annals of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38478232/quality-control-assessment-of-human-adipose-derived-hydrogels
#36
JOURNAL ARTICLE
Haley Lassiter, Jordan Robinson, Katie Hamel, Jeffrey M Gimble, Trivia Frazier, Cecilia Sanchez
Decellularized human-adipose tissue (hDAT) can serve as an alternative to two-dimensional monolayer culture and current ECM hydrogels due to its unlimited availability and cytocompatibility. A major hurdle in the clinical translation and integration of hDAT and other hydrogels into current in vitro culture processes is adherence to current good manufacturing practices (cGMP). Transferring of innovative technologies, including hydrogels, requires the establishing standardized protocols for quality assurance and quality control (QA/QC) of the material...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38477433/managing-vestibular-schwannomas-with-radiosurgery-and-radiotherapy-agree-ii-appraisal-of-clinical-practice-guidelines
#37
JOURNAL ARTICLE
Deepak Lakshmipathy, Eric Winter, Christian Fritz, Jacob Harris, Michelle Gentile, Alvaro Moreira, Karthik Rajasekaran
INTRODUCTION: Vestibular schwannomas (VSs) are rare, benign intracranial tumours that have prompted clinical practice guideline (CPG) creation given their complex management. Our aim was to utilize the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument to assess if such CPGs on the management of VSs with radiosurgery and radiotherapy are of acceptable quality. METHODS: Relevant CPGs were identified following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocols...
March 13, 2024: Journal of Medical Imaging and Radiation Oncology
https://read.qxmd.com/read/38477149/prospective-external-validation-of-iota-methods-for-classifying-adnexal-masses-and-retrospective-assessment-of-two-step-strategy-using-benign-descriptors-and-adnex-a-portuguese-multicenter-study
#38
JOURNAL ARTICLE
A L Borges, M Brito, P Ambrósio, R Condeço, P Pinto, B Ambrósio, F Mahomed, J M R Gama, M J Bernardo, A I Gouveia, D Djokovic
OBJECTIVE: This study aimed to externally and prospectively validate the International Ovarian Tumor Analysis (IOTA) Simple Rules (SRs), Logistic Regression model 2 (LR2) and Assessment of Different NEoplasias in the adneXa (ADNEX) in a Portuguese population, comparing them with operator subjective assessment (SA), Risk-of-Malignancy Index (RMI), as well as with each other. This study also aimed to retrospectively validate IOTA two-step strategy, using modified benign descriptors (MBDs) followed by the application of ADNEX in cases where MBDs were not applicable (MBDs + ADNEX)...
March 13, 2024: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/38476982/anticoagulation-stewardship-to-bridge-the-implementation-gap-in-perioperative-anticoagulation-management
#39
REVIEW
Alfonso J Tafur, Geoffrey D Barnes, Vinai C Bhagirath, James Douketis
Lack of alignment of care protocols among providers in health care is a driver of increased costs and suboptimal patient outcomes. Perioperative anticoagulation management is a good example of a complex area where protocol creation is a clinical challenge that demands input from multiple experts. Questions regarding the need for anticoagulation interruptions are frequent. Yet, due to layers of complexity involving analysis of anticoagulation indication, surgical risk, and anesthesia-associated bleeding risk as well as institutional practices, there is heterogeneity in how these interruptions are approached...
January 2024: TH Open: Companion Journal to Thrombosis and Haemostasis
https://read.qxmd.com/read/38476891/predictive-nomogram-models-for-atrial-fibrillation-in-copd-patients-a-comprehensive-analysis-of-risk-factors-and-prognosis
#40
JOURNAL ARTICLE
Tao Huang, Xingjie Huang, Xueying Cui, Qinghua Dong
The aim of the present study was to identify the independent risk factors and prognostic indicators for atrial fibrillation (AF) in patients with chronic obstructive pulmonary disease (COPD) and to develop predictive nomogram models. This retrospective study included a total of 286 patients with COPD who were admitted to the Second Affiliated Hospital of Guilin Medical College between January 2020 and May 2022. The average age of the patients was 77.11±8.67 years. Based on the presence or absence of AF, the patients were divided into two groups: The AF group (n=87) and the non-AF group (n=199)...
April 2024: Experimental and Therapeutic Medicine
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