keyword
MENU ▼
Read by QxMD icon Read
search

Good clinical practice

keyword
https://www.readbyqxmd.com/read/28732392/systematic-assessment-with-i-scan-magnification-endoscopy-and-acetic-acid-improves-dysplasia-detection-in-patients-with-barrett-s-esophagus
#1
Gideon Lipman, Raf Bisschops, Vinay Sehgal, Jacobo Ortiz-Fernández-Sordo, Rami Sweis, Jose M Esteban, Rifat Hamoudi, Matthew R Banks, Krish Ragunath, Laurence B Lovat, Rehan J Haidry
Background and study aims Enhanced endoscopic imaging with chromoendoscopy may improve dysplasia recognition in patients undergoing assessment of Barrett's esophagus (BE). This may reduce the need for random biopsies to detect more dysplasia. The aim of this study was to assess the effect of magnification endoscopy with I-SCAN (Pentax, Tokyo, Japan) and acetic acid (ACA) on dysplasia detection in BE using a novel mucosal and vascular classification system. Methods BE segments and suspicious lesions were recorded with high definition white-light and magnification endoscopy enhanced using all I-SCAN modes in combination...
July 21, 2017: Endoscopy
https://www.readbyqxmd.com/read/28731214/from-positive-psychology-to-psychopathology-the-continuum-of-attention-deficit-hyperactivity-disorder
#2
Corina U Greven, Jan K Buitelaar, Giovanni A Salum
BACKGROUND: Integration of positive psychology into clinical research and treatment has been slow. This integration can be facilitated by the conceptualisation of mental disorders as the high, symptomatic extreme of continuous normal variation. This assumes that there is also a low, positive extreme, which is, however, unchartered territory. This study aims to examine how well current measures capture the low extreme of mental disorder continua, using attention-deficit hyperactivity disorder (ADHD) as an example...
July 21, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28729414/methods-of-academic-course-planning-for-cancer-biology-ph-d-students-to-enhance-knowledge-of-clinical-oncology
#3
Malcolm D Mattes, Elizabeth Swart, Steven M Markwell, Sijin Wen, Linda C Vona-Davis
Little is known about how clinical oncology concepts are taught to Ph.D. students or the most effective methods of doing so. In this study, electronic surveys were sent to faculty and students at Ph.D. training programs, assessing their institution's methods of clinical oncology education and their perspective on optimal approaches to clinical oncology education. Only 40.0% of students reported any clinical oncology component to their institution's training, and only 26.5% had a clinician on their graduate advisory committee...
July 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28727701/randomized-placebo-controlled-placebo-trial-to-determine-the-placebo-effect-size
#4
Ludger Gerdesmeyer, Tim Klueter, Volker W Rahlfs, Munjed Al Muderis, Amol Saxena, Hans Gollwitzer, Norbert Harrasser, Martin Stukenberg, Alexander Prehn-Kristensen
BACKGROUND: It is the gold standard to use a placebo treatment as the control group in prospective randomized controlled trials (RCTs). Although placebo-controlled trials can reveal an effect of an active treatment, the pure effect of a placebo treatment alone has never been presented or evaluated. No evidence-based, placebo-therapeutic options are currently available, and no placebo-controlled trials have been performed to elucidate the pure placebo effect. OBJECTIVES: To analyze the pure placebo effect on clinical, chronic pain through a blinded RCT...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28727604/preclinical-development-of-ebi-005-an-il-1-receptor-1-inhibitor-for-the-topical-ocular-treatment-of-ocular-surface-inflammatory-diseases
#5
Joseph Kovalchin, Bracken King, Allyson Masci, Elizabeth Hopkins, Jeremy Fry, Jay Hou, Christian Li, Kelly Tenneson, Steve Weber, Gary Wolfe, Kathy Collins, Eric S Furfine
OBJECTIVE: Topical interleukin (IL)-1 receptor (R)1 blockade is therapeutically active in reducing signs and symptoms of dry eye disease. Herein, we describe in vitro and in vivo nonclinical Investigational New Drug (IND)-enabling studies of EBI-005, a novel protein chimera of IL-1β and IL-1 receptor antagonist (IL-1Ra or anakinra) that potently binds IL-1R1 and blocks signaling. These studies provide an assessment of receptor affinity, drug bioavailability, immunogenic response, safety, and tolerability in mice and rabbits...
July 18, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28726923/robust-manufacturing-of-lipid-polymer-nanoparticles-through-feedback-control-of-parallelized-swirling-microvortices
#6
Michael J Toth, Taeyoung Kim, YongTae Kim
A variety of therapeutic and/or diagnostic nanoparticles (NPs), or nanomedicines, have been formulated for improved drug delivery and imaging applications. Microfluidic technology enables continuous and highly reproducible synthesis of NPs through controlled mixing processes at the micro- and nanoscale. Yet, the inherent low-throughput remains a critical roadblock, precluding the probable applications of new nanomedicines for clinical translation. Here we present robust manufacturing of lipid-polymer NPs (LPNPs) through feedback controlled operation of parallelized swirling microvortex reactors (SMRs)...
July 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28726679/accuracy-of-rhenium-188-spect-ct-activity-quantification-for-applications-in-radionuclide-therapy-using-clinical-reconstruction-methods
#7
Pedro L Esquinas, Carlos F Uribe, M Gonzalez, Cristina Rodríguez-Rodríguez, Urs O Häfeli, Anna Celler
The main applications of (188)Re in radionuclide therapies include trans-arterial liver radioembolization and palliation of painful bone-metastases. In order to optimize (188)Re therapies, the accurate determination of radiation dose delivered to tumors and organs at risk is required. Single photon emission computed tomography (SPECT) can be used to perform such dosimetry calculations. However, the accuracy of dosimetry estimates strongly depends on the accuracy of activity quantification in (188)Re images...
July 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28726050/a-single-center-study-a%C3%AE-42-p-tau181-csf-ratio-to-discriminate-ad-from-ftd-in-clinical-setting
#8
Andrea Vergallo, Cecilia Carlesi, Cristina Pagni, Filippo Sean Giorgi, Filippo Baldacci, Lucia Petrozzi, Roberto Ceravolo, Gloria Tognoni, Gabriele Siciliano, Ubaldo Bonuccelli
Abnormal levels of beta amyloid (Aβ42) and tau protein concentrations in the cerebral spinal fluid (CSF) have been largely described in Alzheimer's disease (AD). Thus, CSF analysis of these biomarkers has been incorporated in recent AD diagnostic criteria, and it is increasingly performed for neurodegenerative dementia diagnostic workout in clinical setting. Nevertheless, the precise biomarkers CSF features in neurodegenerative dementia, either AD or Frontotemporal dementia (FTD), are still not fully clear today...
July 19, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28725286/responsibility-without-blame-for-addiction
#9
Hanna Pickard
Drug use and drug addiction are severely stigmatised around the world. Marc Lewis does not frame his learning model of addiction as a choice model out of concern that to do so further encourages stigma and blame. Yet the evidence in support of a choice model is increasingly strong as well as consonant with core elements of his learning model. I offer a responsibility without blame framework that derives from reflection on forms of clinical practice that support change and recovery in patients who cause harm to themselves and others...
2017: Neuroethics
https://www.readbyqxmd.com/read/28725210/multicenter-analytical-validation-of-a%C3%AE-40-immunoassays
#10
Linda J C van Waalwijk van Doorn, Luka Kulic, Marleen J A Koel-Simmelink, H Bea Kuiperij, Alexandra A M Versleijen, Hanne Struyfs, Harry A M Twaalfhoven, Anthony Fourier, Sebastiaan Engelborghs, Armand Perret-Liaudet, Sylvain Lehmann, Marcel M Verbeek, Eugeen J M Vanmechelen, Charlotte E Teunissen
BACKGROUND: Before implementation in clinical practice, biomarker assays need to be thoroughly analytically validated. There is currently a strong interest in implementation of the ratio of amyloid-β peptide 1-42 and 1-40 (Aβ42/Aβ40) in clinical routine. Therefore, in this study, we compared the analytical performance of six assays detecting Aβ40 in cerebrospinal fluid (CSF) in six laboratories according to a recently standard operating procedure (SOP) developed for implementation of ELISA assays for clinical routine...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28723942/comparative-analysis-of-vaginal-microbiota-sampling-using-16s-rrna-gene-analysis
#11
Seppo Virtanen, Ilkka Kalliala, Pekka Nieminen, Anne Salonen
BACKGROUND: Molecular methods such as next-generation sequencing are actively being employed to characterize the vaginal microbiota in health and disease. Previous studies have focused on characterizing the biological variation in the microbiota, and less is known about how factors related to sampling contribute to the results. Our aim was to investigate the impact of a sampling device and anatomical sampling site on the quantitative and qualitative outcomes relevant for vaginal microbiota research...
2017: PloS One
https://www.readbyqxmd.com/read/28722596/therapeutic-response-in-adult-patients-with-nonsevere-chronic-paracoccidioidomycosis-treated-with-sulfamethoxazole-trimethoprim-a-retrospective-study
#12
Andreia F Nery, Natasha P Crepaldi, Soraya B R S Rossi, Tomoko Tadano, Fabio A Leal-Santos, Rosane Christine Hahn, Valfredo M Menezes, Cor Jesus F Fontes
According to the Brazilian Consensus on Paracoccidioidomycosis (PCM), itraconazole is the drug of choice for treatment. However, the combination of sulfamethoxazole and trimethoprim (SMX-TMP) is most commonly used in clinical practice because of its higher availability in the public health services. The aims of this study were to evaluate the therapeutic response of patients with nonsevere chronic PCM to SMX-TMP and highlight the factors related to treatment failure. An adequate therapeutic response was defined as completely improved disease signs and symptoms after medication use for a minimum of 6 months, followed by normalized hematological and biochemical changes, radiological improvements, and negative mycological examination findings...
May 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722141/failure-to-rescue-as-a-nurse-sensitive-indicator
#13
Jane Mushta, Kathy L Rush, Elizabeth Andersen
PROBLEM: The aim of this concept analysis was to clarify failure to rescure as a nurse-sensitive indicator. Although the concept of failure to rescue as a nurse-sensitive outcome has appeared in the nursing literature for over a decade, conceptual clarity is needed to address its variable and ambiguous use in health care. METHODS: Walker and Avant's eight-stage method of concept analysis was used to explore the concept of failure to rescue in nursing practice. Twenty-one papers were retrieved from Cumulative Index of Nursing and Allied Health Literature (CINAHL) and MEDLINE databases and selected for review and synthesis...
July 19, 2017: Nursing Forum
https://www.readbyqxmd.com/read/28721305/fully-automated-gmp-production-of-68-ga-ga-do3a-vs-cys-40-exendin-4-for-clinical-use
#14
Irina Velikyan, Ulrika Rosenstrom, Olof Eriksson
[(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4/PET-CT targeting glucagon like peptide-1 receptor (GLP-1R) has previously demonstrated its potential clinical value for the detection of insulinomas. The production and accessibility of this radiopharmaceutical is one of the critical factors in realization of clinical trials and routine clinical examinations. Previously, the radiopharmaceutical was prepared manually, however larger scale of clinical trials and healthcare requires automation of the production process in order to limit the operator radiation dose as well as improve tracer manufacturing robustness and on-line documentation for enhanced good manufacturing practice (GMP) compliance...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28721089/combination-treatment-of-neuropathic-pain-danish-expert-recommendations-based-on-a-delphi-process
#15
EDITORIAL
Jakob Vormstrup Holbech, Anne Jung, Torsten Jonsson, Mette Wanning, Claus Bredahl, Flemming W Bach
BACKGROUND: Current Danish treatment algorithms for pharmacological treatment of neuropathic pain (NeP) are tricyclic antidepressants (TCA), gabapentin and pregabalin as first-line treatment for the most common NeP conditions. Many patients have insufficient pain relief on monotherapy, but combination therapy had not been included in guidelines until recently. Based on clinical empiricism and scientific evidence, a Delphi consensus process provided a consolidated guidance on pharmacological combination treatment of NeP...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28721041/high-intensity-focused-ultrasound-triggered-nanoscale-bubble-generating-liposomes-for-efficient-and-safe-tumor-ablation-under-photoacoustic-imaging-monitoring
#16
Gang Feng, Lan Hao, Chunyan Xu, Haitao Ran, Yuanyi Zheng, Pan Li, Yang Cao, Qi Wang, Jizhu Xia, Zhigang Wang
High-intensity focused ultrasound (HIFU) is widely applied to tumors in clinical practice due to its minimally invasive approach. However, several issues lower therapeutic efficiency in some cases. Many synergists such as microbubbles and perfluorocarbon nanoparticles have recently been used to improve HIFU treatment efficiency, but none were determined to be effective and safe in vivo. In this study, nanoscale bubble-generating liposomes (liposomes containing ammonium bicarbonate [Lip-ABC]) were prepared by film hydration followed by sequential extrusion...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28717629/ultrasound-measures-of-tendon-thickness-intra-rater-inter-rater-and-inter-machine-reliability
#17
María Elena Del Baño-Aledo, Jacinto Javier Martínez-Payá, José Ríos-Díaz, Silvia Mejías-Suárez, Sergio Serrano-Carmona, Ana de Groot-Ferrando
BACKGROUND: Ultrasound imaging is often used by physiotherapists and other healthcare professionals but the reliability of image acquisition with different ultrasound machines is unknown. The objective was to compare the intra-rater, inter-rater and intermachine reliability of thickness measurements of the plantar fascia (PF), Achilles tendon (AT), patellar tendon (PT) and elbow common extensor tendon (ECET) with musculoskeletal ultrasound imaging (MSUS). METHODS: Tendon thickness was measured in four anatomical structures (14 participants, 28 images per tendon) by two sonographers and with two different ultrasound machines...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28717605/i-s-mu-l-t-first-time-patellar-dislocation-guidelines
#18
Mario Vetrano, Francesco Oliva, Salvatore Bisicchia, Michela Bossa, Angelo De Carli, Luigi Di Lorenzo, Davide Erroi, Alfonso Forte, Calogero Foti, Antonio Frizziero, Giuseppe Gasparre, Alessio Giai Via, Bernardo Innocenti, Umile Giuseppe Longo, Asmaa Mahmoud, Stefano Masiero, Daniele Mazza, Simone Natali, Christian Notarangelo, Leonardo Osti, Johnny Padulo, Leonardo Pellicciari, Fabrizio Perroni, Eleonora Piccirilli, Carlo Ramponi, Giuseppe Salvatore, Alfredo Schiavone Panni, Tania Suarez, Umberto Tarantino, Filippo Vittadini, Maria Chiara Vulpiani, Andrea Ferretti, Nicola Maffulli
Primary traumatic patellar dislocation is common, particularly in young active individuals. A consensus on its management is still lacking. The present work provides easily accessible guidelines to be considered as recommendations for a good clinical practice developed through a process of systematic review of the literature and expert opinion, to improve the quality of care and rationalize the use of resources. LEVEL OF EVIDENCE: Ia.
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28716064/informed-consent-in-randomised-controlled-trials-development-and-preliminary-evaluation-of-a-measure-of-participatory-and-informed-consent-pic
#19
Julia Wade, Daisy Elliott, Kerry N L Avery, Daisy Gaunt, Grace J Young, Rebecca Barnes, Sangeetha Paramasivan, W Bruce Campbell, Jane M Blazeby, Alison J Birtle, Rob C Stein, David J Beard, Alison W Halliday, Jenny L Donovan
BACKGROUND: Informed consent (IC) is an ethical and legal prerequisite for trial participation, yet current approaches evaluating participant understanding for IC during recruitment lack consistency. No validated measure has been identified that evaluates participant understanding for IC based on their contributions during consent interactions. This paper outlines the development and formative evaluation of the Participatory and Informed Consent (PIC) measure for application to recorded recruitment appointments...
July 17, 2017: Trials
https://www.readbyqxmd.com/read/28715013/self-assembling-covalent-organic-framework-functionalized-magnetic-graphene-hydrophilic-biocomposites-as-an-ultrasensitive-matrix-for-n-linked-glycopeptide-recognition
#20
Jiaxi Wang, Jie Li, Mingxia Gao, Xiangmin Zhang
The development of additional functions and applications of covalent organic framework (COF)-derived materials still remains highly desired. In our work, a novel COF-functionalized magnetic graphene biocomposite (MagG@COF-5) was first developed as an ultrasensitive hydrophilic matrix via a facile self-assembly method for efficiently recognizing N-linked glycopeptides. By integrating the characteristics of the magnetic graphene and COF-5 layer, the MagG@COF-5 owns features of an outstanding magnetic response, a high specific area, strong hydrophilic properties and a unique size-exclusion effect...
July 17, 2017: Nanoscale
keyword
keyword
77661
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"