keyword
https://read.qxmd.com/read/38493485/digital-health-technologies-compounding-the-existing-ethical-challenges-of-the-right-not-to-know
#1
JOURNAL ARTICLE
Richard C Armitage
INTRODUCTION: Doctors hold a prima facie duty to respect the autonomy of their patients. This manifests as the patient's 'right' not to know when patients wish to remain unaware of medical information regarding their health, and poses ethical challenges for good medical practice. This paper explores how the emergence of digital health technologies might impact upon the patient's 'right' not to know. METHOD: The capabilities of digital health technologies are surveyed and ethical implications of their effects on the 'right' not to know are explored...
March 17, 2024: Journal of Evaluation in Clinical Practice
https://read.qxmd.com/read/38492134/understanding-the-angiogenic-characteristics-of-clinical-grade-mesenchymal-stromal-cells-isolated-from-human-umbilical-cord
#2
JOURNAL ARTICLE
Charlotte Carcopino, Elisa Rossi, Miryam Mebarki, Divina El Hamaoui, Pascale Gaussem, Jérôme Larghero, David M Smadja, Audrey Cras
Addressing the challenges in managing ischemic tissue repair and remodelling remains a prominent clinical concern. Current research is heavily concentrated on identifying innovative cell-based therapies with the potential to enhance revascularization in patients affected by these diseases. We have previously developed and validated a manufacturing process for human umbilical cord mesenchymal stromal cells (UC-MSCs)-based cell therapy medicinal product, according to Good Manufacturing Practices. In this study, we demonstrate that these UC-MSCs enhance the proliferation and migration of endothelial cells and the formation of capillary structures...
March 16, 2024: Stem cell reviews and reports
https://read.qxmd.com/read/38491851/perceptions-of-clinical-experience-and-scientific-evidence-in-medical-decision-making-a-survey-of-a-stratified-random-sample-of-swedish-health-care-professionals
#3
JOURNAL ARTICLE
Barry Dewitt, Johannes Persson, Annika Wallin
BACKGROUND: Evidence-based medicine recognizes that clinical expertise gained through experience is essential to good medical practice. However, it is not known what beliefs clinicians hold about how personal clinical experience and scientific knowledge contribute to their clinical decision making and how those beliefs vary between professions, which themselves vary along relevant characteristics, such as their evidence base. DESIGN: We investigate how years in the profession influence health care professionals' beliefs about science and their clinical experience through surveys administered to random samples of Swedish physicians, nurses, occupational therapists, dentists, and dental hygienists...
March 16, 2024: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://read.qxmd.com/read/38491476/cultivating-compassion-in-medicine-a-toolkit-for-medical-students-to-improve-self-kindness-and-enhance-clinical-care
#4
JOURNAL ARTICLE
Krisha K Mehta, Shafkat Salam, Austin Hake, Rebecca Jennings, Afra Rahman, Stephen G Post
BACKGROUND: Compassionate care lies at the foundation of good patient care and is a quality that patients and providers continue to value in the fast-paced setting of contemporary medicine. Compassion is often discussed superficially in medical school curricula, but the practical aspect of learning this skill is often not taught using a formal framework. In the present work, the authors present an 8-session curriculum with a mindfulness-based approach to compassion that addresses this need...
March 15, 2024: BMC Medical Education
https://read.qxmd.com/read/38490877/extensor-tendon-transfer-for-fracture-related-extensor-pollicis-longus-rupture-long-term-outcome-case-series
#5
JOURNAL ARTICLE
Alexander J Adams, Saral J Patel, Sebastian D Arango, Kaleb Smithson, Rick J Tosti, Andrew J Miller
BACKGROUND: Spontaneous rupture of the extensor pollicis longus (EPL) tendon following both nonoperative and operative treatment of distal radius fractures has been well described. PURPOSE: The purpose of this study was to assess long-term outcomes of extensor indicis proprius to EPL tendon transfers for patients following distal radius fracture and EPL tendon repair. STUDY DESIGN: Retrospective case series focusing on long-term clinical outcomes...
March 14, 2024: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://read.qxmd.com/read/38490322/prospective-multi-centric-international-single-arm-cohort-study-to-assess-a-synthetic-polyamide-suture-material-in-oral-surgery-to-close-the-mucosa-mucoda-study
#6
JOURNAL ARTICLE
S García-González, S Aboul-Hosn Centenero, P Baumann, I Fita-Esteban, F Hernández-Alfaro, N Weyer
OBJECTIVES: The aim was to collect different clinical parameters systematically and proactively regarding safety, effectiveness, and performance of a nylon monofilament suture under routine clinical practice for oral surgery. METHODS: The study design was prospective, bicentric, international, single-armed, and observational. A non-absorbable suture was applied to close the mucosa after different dental surgical interventions. Main objective was the incidence of combined postoperative complications until suture removal...
March 13, 2024: Journal of Dentistry
https://read.qxmd.com/read/38489953/external-validation-and-comparison-of-mbe-edema-and-modified-edema-scores-for-predicting-malignant-cerebral-edema-in-chinese-patients-with-large-hemispheric-infarction-patients-without-revascularization
#7
JOURNAL ARTICLE
Anqi Tang, Xiaoming Ma, Yi Ren, Hao Zhang, Wei Xie, Meng Liu, Shiying Sheng, Keshi Mao
BACKGROUND: Malignant cerebral edema (MCE) is a severe condition characterized by rapid neurological deterioration and a potentially poor prognosis. Scoring systems including the malignant brain edema (MBE) score, Enhanced Detection of Edema in Malignant Anterior Circulation Stroke score (EDEMA), and modified EDEMA score, have been developed to predict MCE in patients with large hemispheric infarction (LHI). We aimed to externally validate and comparethe predictive efficacy of these scores in LHI patients within 48 h of onset and not undergoing reperfusion therapy...
March 13, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/38489823/performance-of-the-impact-and-crash-prognostic-models-for-traumatic-brain-injury-in-a-contemporary-multicenter-cohort-a-track-tbi-study
#8
JOURNAL ARTICLE
John K Yue, Young M Lee, Xiaoying Sun, Thomas A van Essen, Mahmoud M Elguindy, Patrick J Belton, Dana Pisică, Ana Mikolic, Hansen Deng, John H Kanter, Michael A McCrea, Yelena G Bodien, Gabriela G Satris, Justin C Wong, Vardhaan S Ambati, Ramesh Grandhi, Ava M Puccio, Pratik Mukherjee, Alex B Valadka, Phiroz E Tarapore, Michael C Huang, Anthony M DiGiorgio, Amy J Markowitz, Esther L Yuh, David O Okonkwo, Ewout W Steyerberg, Hester F Lingsma, David K Menon, Andrew I R Maas, Sonia Jain, Geoffrey T Manley
OBJECTIVE: The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticosteroid Randomization After Significant Head Injury (CRASH) prognostic models for mortality and outcome after traumatic brain injury (TBI) were developed using data from 1984 to 2004. This study examined IMPACT and CRASH model performances in a contemporary cohort of US patients. METHODS: The prospective 18-center Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study (enrollment years 2014-2018) enrolled subjects aged ≥ 17 years who presented to level I trauma centers and received head CT within 24 hours of TBI...
March 15, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38489696/network-pharmacology-and-molecular-docking-to-explore-the-mechanism-of-a-clinical-proved-recipe-for-external-use-of-clearing-heat-and-removing-dampness-in-the-treatment-of-immune-related-cutaneous-adverse-events
#9
JOURNAL ARTICLE
Shuyi Chen, Rui Yu, Fangmin Zhao, Lin Sun, Yudan Yin, Gaochenxi Zhang, Qunwei Chen, Qijin Shu
Immune-related cutaneous adverse events (ircAEs) will undermine the patients' quality of lives, and interrupt the antitumor therapy. A clinical proved recipe for external use of clearing heat and removing dampness (Qing-Re-Li-Shi Formula, hereinafter referred to as "QRLSF") is beneficial to the treatment of ircAEs in clinical practice. Our study will elucidate the mechanism of QRLSF against ircAEs based on network pharmacology and molecular docking. The active components and corresponding targets of QRLSF were collected through traditional Chinese medicine systems pharmacology database...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489323/potential-efficacy-of-t-and-b-lymphocyte-targeted-therapies-on-articular-involvement-of-patients-with-rheumatoid-arthritis-and-systemic-sclerosis-overlap-syndrome-results-from-a-2-centre-series-of-22-cases
#10
JOURNAL ARTICLE
Nans Lebel, Isabelle Marie, Julien Grosjean, Pauline Brevet, Mathilde Leclercq, Anaël Dumont, Hervé Levesque, Ygal Benhamou, Christian Marcelli, Thierry Lequerre, Olivier Vittecoq
OBJECTIVES: To analyse in routine practice the efficacy of targeted therapies on joint involvement of patients with rheumatoid arthritis/systemic sclerosis (RA/SSc) overlap syndrome. METHODS: This was a retrospective analysis of medical records of two academic centres over a 10-year period. Joint response to targeted therapies was measured according to EULAR criteria based on Disease Activity Score (DAS)-28. In addition, changes in CRP level and glucocorticoid consumption were recorded...
March 13, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38488978/diagnosis-and-treatment-of-paget-s-disease-of-bone-position-paper-from-the-italian-society-of-osteoporosis-mineral-metabolism-and-skeletal-diseases-siommms
#11
JOURNAL ARTICLE
D Rendina, A Falchetti, D Diacinti, F Bertoldo, D Merlotti, S Giannini, L Cianferotti, G Girasole, M Di Monaco, S Gonnelli, N Malavolta, S Minisola, F Vescini, M Rossini, B Frediani, I Chiodini, F Asciutti, L Gennari
INTRODUCTION: Paget's disease of bone is a focal skeletal disorder causing bone deformities and impairing bone quality. Despite the prevalence of asymptomatic cases is increasing, the progression of the disease can lead to invalidating complications that compromise the quality of life. Doubts on clinical and therapeutic management aspects exist, although beneficial effects of antiresorptive drugs, particularly bisphosphonates are known. However, limited information is available from randomized controlled trials on the prevention of disease complications so that somewhat contrasting positions about treatment indications between expert panels from the main scientific societies of metabolic bone diseases exist...
March 15, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38488946/iscev-standard-for-clinical-pattern-electroretinography-2024-update
#12
JOURNAL ARTICLE
D A Thompson, M Bach, J J McAnany, M Šuštar Habjan, S Viswanathan, A G Robson
The pattern electroretinogram (PERG) is a localized retinal response evoked by a contrast-reversing pattern, usually a black and white checkerboard, which provides information about macular and retinal ganglion cell function. This document, from the International Society for Clinical Electrophysiology of Vision (ISCEV; www.iscev.org ) presents an updated and revised Standard for clinical PERG testing. This replaces the 2013 and all earlier versions. Minimum protocols for basic PERG stimuli, recording methods and reporting are specified, to promote consistency of methods for diagnosis and monitoring purposes, while responding to evolving clinical practices and technology...
March 15, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38488627/the-research-question-the-what-why-and-how-in-hand-surgery
#13
EDITORIAL
Simon Farnebo, Leila Harhaus
Identifying a good research question is one of the most important steps when laying the foundation of a research project. A good research question can aim to answer a hotly debated clinical issue, challenge a pre-existing dogma or make a contribution to specific aspects of a broader field of study. The difficulty in defining the question lies with pinpointing an important research topic or an area that is characterized by a lack of knowledge (the What), grasping the significance of how a precisely defined study can potentially impact on clinical practices (the Why) and determining the optimal study design tailored to answer the specific question (the How)...
March 15, 2024: Journal of Hand Surgery, European Volume
https://read.qxmd.com/read/38487467/house-dust-mite-sublingual-allergen-immunotherapy-tablet-is-safe-and-well-tolerated-in-dutch-clinical-practice
#14
JOURNAL ARTICLE
Žana Tempels-Pavlica, Mark C J Aarts, Paco M J Welsing, Akke-Nynke van der Meer, Leonard P van der Zwan, Elena Uss, André C Knulst
BACKGROUND: Half (49%) of clinically diagnosed allergic rhinitis (AR) patients are sensitized to house dust mite (HDM). If allergen avoidance and symptomatic medication fail, allergen immunotherapy may be indicated. OBJECTIVE: We investigated safety and tolerability of HDM-sublingual immunotherapy by HDM-SLIT tablets in Dutch daily clinical practice. METHODS: Daily intake of 12 SQ-HDM SLIT-tablet was investigated in a prospective, multicenter, observational study (EUPAS43753)...
2024: Front Allergy
https://read.qxmd.com/read/38486952/measurement-bias-in-caregiver-report-of-early-childhood-behavior-problems-across-demographic-factors-in-an-echo-wide-diverse-sample
#15
JOURNAL ARTICLE
Shuting Zheng, Maxwell Mansolf, Monica McGrath, Marie L Churchill, Traci A Bekelman, Patricia A Brennan, Amy E Margolis, Sara S Nozadi, Theresa M Bastain, Amy J Elliott, Kaja Z LeWinn, Julie A Hofheimer, Leslie D Leve, Brandon Rennie, Emily Zimmerman, Carmen A Marable, Cindy T McEvoy, Chang Liu, Alexis Sullivan, Tracey J Woodruff, Samiran Ghosh, Bennett Leventhal, Assiamira Ferrara, Johnnye Lewis, Somer Bishop
BACKGROUND: Research and clinical practice rely heavily on caregiver-report measures, such as the Child Behavior Checklist 1.5-5 (CBCL/1.5-5), to gather information about early childhood behavior problems and to screen for child psychopathology. While studies have shown that demographic variables influence caregiver ratings of behavior problems, the extent to which the CBCL/1.5-5 functions equivalently at the item level across diverse samples is unknown. METHODS: Item-level data of CBCL/1...
March 2024: JCPP Adv
https://read.qxmd.com/read/38485661/-it-was-classed-as-a-nonemergency-women-s-experiences-of-kidney-disease-and-preconception-decision-making-family-planning-and-parenting-in-the-united-kingdom-during-covid-19
#16
JOURNAL ARTICLE
Leah Mc Laughlin, Jane Noyes, Barbara Neukirchinger, Denitza Williams, Rhiannon Phillips, Sian Griffin
OBJECTIVES: To investigate the experiences of women with kidney disease, residing in the United Kingdom (UK), living through the first 18 months of the COVID-19 pandemic with specific focus on preconception decision-making, family planning, and parenting. METHODS: We conducted a mixed-methods study, comprising an online survey and follow-up interviews, with UK-resident women aged 18-50. RESULTS: We received 431 surveys and conducted 30 interviews...
March 14, 2024: Perspectives on Sexual and Reproductive Health
https://read.qxmd.com/read/38485518/age-and-sex-specific-mr-feature-tracking-reference-values-of-right-atrial-deformation-in-healthy-adults
#17
JOURNAL ARTICLE
Yiyuan Gao, Zhen Zhang, Lingnan Guo, Jingjing Shi, Fan Zhang, Yifan Guo, Ping Xiang, Shanshan Zhou, Jianan Xie, Gengxiao Li, Zhiwei Zhao, Maosheng Xu, Kuncheng Li, Gerald M Pohost
BACKGROUND: Although right atrial (RA) myocardial deformation has important implications for patient diagnosis, prognosis, and risk stratification, its implementation in clinical practice has been hampered by limited normal reference values, especially in Asian populations. PURPOSE: To establish age- and sex-specific reference values for RA strain, strain rate (SR), and displacement based on a large sample of healthy Chinese adults using MR-feature tracking (MR-FT)...
March 14, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38484865/thyroid-eye-disease-pilot-study-comparison-between-patients-in-united-states-based-and-india-based-practices
#18
JOURNAL ARTICLE
Sathyadeepak Ramesh, Milind Naik, Alison Watson, Qiang Zhang, Ellen Peskin, James Sharpe, Kieran Alessi, Leslie Hyman
PURPOSE: Thyroid eye disease (TED) phenotype varies by ethnicity/race and genetic/environmental factors. This study compared demographic and clinical characteristics of TED patients from the US and India. DESIGN: Observational pilot study METHODS: 64 patients with TED ages ≥18 years old with active disease (onset of symptoms ≤18 months or presenting clinical activity score (CAS) ≥4) were recruited between March and October 2021 from clinical practices in the United States (Philadelphia, PA) (n= 30) and India (Hyderabad, India) (n=34)...
March 12, 2024: American Journal of Ophthalmology
https://read.qxmd.com/read/38484373/-neurosurgical-treatment-of-tumors-of-the-pineal-region-literature-review-and-overview-of-cases-at-omiii
#19
JOURNAL ARTICLE
Tamás Mezei, János Báskay, Péter Pollner, Viktória Kovács, Balázs Markia, Gábor Nagy, András Bajcsay, László Sipos
Pineal region tumors account for less than 1% of adult supratentorial tumors. Their treatment requires a multimodality approach. Previously, the treatment of choice was direct surgery, which is associated with high surgical risk. Advances in minimally invasive techniques and onco-radiotherapy offer a safe and multimodal personalized therapy. The aim of our study was to describe the practice of our Institute based on combined endoscopic and radiotherapy techniques. We performed a retrospective clinical study...
March 14, 2024: Magyar Onkologia
https://read.qxmd.com/read/38484307/the-role-of-18-f-fdg-pet-ct-in-the-characterization-of-thymic-epithelial-tumors-at-initial-stage
#20
JOURNAL ARTICLE
Caner Civan, Zeynep Gozde Ozkan, Berker Ozkan, Emine Goknur Isik, Eren Erdogdu, Duygu Has Simsek, Salih Duman, Yasemin Sanli, Murat Kara, Serkan Kuyumcu, Alper Toker
Purpose: The aim of this study was to evaluate the potential role of [18 F]FDG positron emission tomography/computed tomography (PET/CT) in the characterization of thymic epithelial tumors (TETs). Materials and Methods: A total of 73 patients who underwent preoperative [18 F]FDG PET/CT were included in this study. Visual total score (VTS), maximum standard uptake values (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and heterogeneity index (HI) parameters were analyzed to investigate the prediction of histopathologic grade and advanced stage...
March 14, 2024: Cancer Biotherapy & Radiopharmaceuticals
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