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Dr m gh

Menaka C Thounaojam, Folami L Powell, Sagar Patel, Diana R Gutsaeva, Amany Tawfik, Sylvia B Smith, Julian Nussbaum, Norman L Block, Pamela M Martin, Andrew V Schally, Manuela Bartoli
The potential therapeutic effects of agonistic analogs of growth hormone-releasing hormone (GHRH) and their mechanism of action were investigated in diabetic retinopathy (DR). Streptozotocin-induced diabetic rats (STZ-rats) were treated with 15 μg/kg GHRH agonist, MR-409, or GHRH antagonist, MIA-602. At the end of treatment, morphological and biochemical analyses assessed the effects of these compounds on retinal neurovascular injury induced by hyperglycemia. The expression levels of GHRH and its receptor (GHRH-R) measured by qPCR and Western blotting were significantly down-regulated in retinas of STZ-rats and in human diabetic retinas (postmortem) compared with their respective controls...
December 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
Christopher Hine, Hyo-Jeong Kim, Yan Zhu, Eylul Harputlugil, Alban Longchamp, Marina Souza Matos, Preeti Ramadoss, Kevin Bauerle, Lear Brace, John M Asara, C Keith Ozaki, Sheue-Yann Cheng, Subhankar Singha, Kyo Han Ahn, Alec Kimmelman, Ffolliott M Fisher, Pavlos Pissios, Dominic J Withers, Colin Selman, Rui Wang, Kelvin Yen, Valter D Longo, Pinchas Cohen, Andrzej Bartke, John J Kopchick, Richard Miller, Anthony N Hollenberg, James R Mitchell
Decreased growth hormone (GH) and thyroid hormone (TH) signaling are associated with longevity and metabolic fitness. The mechanisms underlying these benefits are poorly understood, but may overlap with those of dietary restriction (DR), which imparts similar benefits. Recently we discovered that hydrogen sulfide (H2 S) is increased upon DR and plays an essential role in mediating DR benefits across evolutionary boundaries. Here we found increased hepatic H2 S production in long-lived mouse strains of reduced GH and/or TH action, and in a cell-autonomous manner upon serum withdrawal in vitro...
June 6, 2017: Cell Metabolism
Kimber M Simmons, Kim McFann, Iman Taki, Edwin Liu, Georgeanna J Klingensmith, Marian J Rewers, Brigitte I Frohnert
OBJECTIVE: To evaluate the association between bone mineral density (BMD), glycemic control (hemoglobin A1c [HbA1c]), and celiac autoimmunity in children with type 1 diabetes mellitus (T1D) and in an appropriate control population. STUDY DESIGN: BMD was assessed cross-sectionally in 252 children with T1D (123 positive for anti-tissue transglutaminase antibody [tTGA] and 129 matched children who were negative for tTGA). In addition, BMD was assessed in 141 children without diabetes who carried T1D-associated HLD-DR, DQ genotypes (71 positive for tTGA and 70 negative)...
February 2016: Journal of Pediatrics
Frederick M Stanley, Kathryn M Linder, Timothy J Cardozo
Plasminogen activator inhibitor type 1 (PAI-1) is a multifunctional protein that has important roles in inflammation and wound healing. Its aberrant regulation may contribute to many disease processes such as heart disease. The PAI-1 promoter is responsive to multiple inputs including cytokines, growth factors, steroids and oxidative stress. The statin drugs, atorvastatin, mevastatin and rosuvastatin, increased basal and stimulated expression of the PAI-1 promoter 3-fold. A statin-responsive, nuclear hormone response element was previously identified in the PAI-1 promoter, but it was incompletely characterized...
2015: PloS One
H J Kang, N H Trang, M Baik
This study determined the effects of dietary restriction on growth and the expression of lipid metabolism and growth hormone signaling genes in the longissimus dorsi muscle (LM) of Korean cattle. Thirty-one Korean cattle steers (average age 10.5 months) were allocated to normal (N; n = 16) or dietary restriction (DR; n = 15) groups. The feeding trial consisted of two stages: for the 8-month growing period, the DR group was fed 80% of the food intake of the normal diet, and for the 6-month growth-finishing period, the DR group was fed a DR total mixed ration with 78...
August 2015: Asian-Australasian Journal of Animal Sciences
Gene P Ables, Holly M Brown-Borg, Rochelle Buffenstein, Christopher D Church, Amany K Elshorbagy, Vadim N Gladyshev, Tsang-Hai Huang, Richard A Miller, James R Mitchell, John P Richie, Blanka Rogina, Martha H Stipanuk, David S Orentreich, Norman Orentreich
It has been 20 years since the Orentreich Foundation for the Advancement of Science, under the leadership Dr. Norman Orentreich, first reported that low methionine (Met) ingestion by rats extends lifespan (Orentreich et al., 1993). Since then, several studies have replicated the effects of dietary methionine restricted (MR) in delaying age-related diseases (Richie et al., 1994; Miller et al., 2005; Ables et al., 2012; Sanchez-Roman and Barja, 2013). We report the abstracts from the First International Mini-Symposium on Methionine Restriction and Lifespan held in Tarrytown, NY, September 2013...
2014: Frontiers in Genetics
E Romanowska, E Parys, J Poskuta
CO2 exchange were measured on pea seedlings (Pisum sativum L. var. Bördi) cultivated from seeds imbibed either in water (C-plants) or in gibberellic acid (GA3) at the concentration of 25 μg/1 (GA-plants), and then grown under 17 W/m(2) blue light (B-plants) or 11 W/m(2) red light (R-plants).When measured under the same light conditions as during growth the net photosynthesis (APS) rate in B-plants was about twice higher than that in R-plants. Dark respiration (DR) rate was 70% higher in B- than in R-plants...
September 1984: Photosynthesis Research
E Zavadova, M Vocka, J Spacek, B Konopasek, T Fucikova, L Petruzelka
In view of the fact that insufficiency in immune response often correlates with poor prognosis, research in recent years has focused on the task of describing the precise status and function of the immune system and its possible effect on cancer patients. Although more than two thirds of treated patients respond to endocrine therapy, most patients with metastatic breast cancer develop a resistance to it. Estrogen modulates angiogenesis, partially through its effects on vascular endothelial growth factor (VEGF)...
2014: Neoplasma
K W Maas, S S A Y Biere, I M W van Hoogstraten, D L van der Peet, M A Cuesta
BACKGROUND: This study was performed as a substudy analysis of a randomized trial comparing conventional open esophagectomy [open surgical technique (OE)] by thoracotomy and laparotomy with minimally invasive esophagectomy [minimally invasive procedure (MIE)] by thoracoscopy and laparoscopy. This additional analysis focuses on the immunological changes and surgical stress response in these two randomized groups of a single center. METHODS: Patients with a resectable esophageal cancer were randomized to OE (n = 13) or MIE (n = 14)...
January 2014: World Journal of Surgery
E Zavadova, M Vocka, J Spacek, B Konopasek, T Fucikova, L Petruzelka
In view of the fact that insufficiency in immune response often correlates with poor prognosis, research in recent years has focused on the task of describing the precise status and function of the immune system and its possible effect on cancer patients. Although more than two thirds of treated patients respond to endocrine therapy, most patients with metastatic breast cancer develop a resistance to it. Estrogen modulates angiogenesis, partially through its effects on vascular endothelial growth factor (VEGF)...
September 20, 2013: Neoplasma
P Borrione, L Grasso, M Pautasso, A Parisi, F Quaranta, E Ciminelli, A Di Gianfrancesco, L Di Luigi, F Pigozzi
The aim of the present study is to evaluate the effects induced by increasing concentrations of human recombinant growth hormone on T lymphocytes. Ten healthy volunteers and twelve subjects with symptomatic allergies were enrolled in the study. Peripheral blood mononuclear cells and purified T lymphocytes were cultured in the presence of graded concentrations of growth hormone. Following appropriate in vitro stimulations, the proportion of apoptotic T cells, the percentage of activated T lymphocyte subpopulations, the phytohemagglutinin responsiveness and the Th2 response were assessed by flow cytometry analysis...
January 2012: International Journal of Immunopathology and Pharmacology
A A F A Veenhof, M S Vlug, M H G M van der Pas, C Sietses, D L van der Peet, E S M de Lange-de Klerk, H J Bonjer, W A Bemelman, M A Cuesta
OBJECTIVE: To evaluate the effect of laparoscopic or open colectomy with fast track or standard perioperative care on patient's immune status and stress response after surgery. METHODS: Patients with nonmetastasized colon cancer were randomized to laparoscopic or open colectomy with fast track or standard care. Blood samples were taken preoperatively (baseline), and 1, 2, 24, and 72 hours after surgery. Systemic HLA-DR expression, C-reactive protein, interleukin-6, growth hormone, prolactin, and cortisol were analyzed...
February 2012: Annals of Surgery
Melissa G Lechner, Carolina Megiel, Sarah M Russell, Brigid Bingham, Nicholas Arger, Tammy Woo, Alan L Epstein
BACKGROUND: Tumor immune tolerance can derive from the recruitment of suppressor cell populations, including myeloid-derived suppressor cells (MDSC). In cancer patients, MDSC accumulation correlates with increased tumor burden, but the mechanisms of MDSC induction remain poorly understood. METHODS: This study examined the ability of human tumor cell lines to induce MDSC from healthy donor PBMC using in vitro co-culture methods. These human MDSC were then characterized for morphology, phenotype, gene expression, and function...
2011: Journal of Translational Medicine
A A F A Veenhof, C Sietses, B M E von Blomberg, I M W van Hoogstraten, M H G M vd Pas, W J H J Meijerink, D L vd Peet, M P vd Tol, H J Bonjer, M A Cuesta
PURPOSE: This study evaluated differences in stress response and immunological function following laparoscopic and conventional total mesorectal excision (TME) for rectal cancer. METHODS: Patients with non-metastasized rectal cancer were prospectively randomized to open (n = 18) or laparoscopic (n = 22) TME. Blood samples were taken preoperatively (baseline), 2, 24, and 72 h following surgery. Systemic white blood cell and monocyte count, C-reactive protein, interleukin-6 (IL-6), interleukin-8 (IL-8), HLA-DR expression on monocytes, growth hormone, prolactin, and cortisol were measured...
January 2011: International Journal of Colorectal Disease
S U Dani, M A C Dani, I L Freire, S P Gouvea, F B Knackfuss, F P Lima, M E Z Mercadante, E Monteiro, S M G Paggiaro, A G Razook, H C Yehia
Growth hormone (GH) is a part of the somatotropic axis that controls metabolism, growth, development and aging in a wide range of animals. Mutations that reduce GH signaling have been associated with extended life spans and increased longevity in ways similar to what is observed in dietary restriction (DR) models. However, the mechanism by which DR works is not well understood. Here, we show that DR works as a factor in the evolution of the genetic make-up of domestic cattle. In a series of 6864 bovines of seven Bos indicus and tropically adapted Bos taurus breeds, the frequency of a short, wild-type allele of the promoter region of the bovine GH gene, G1 allele, varied from 2...
June 1, 2010: Genetics and Molecular Research: GMR
Yong Lu, Didier J L Mekoo, Kedong Ouyang, Xiangbing Hu, Yanhua Liu, Ming Lin, Liang Jin, Rongyue Cao, Taiming Li, Yankai Zhang, Hao Fan, Jingjing Liu
Previous studies demonstrated that the elevated expression and receptor binding of gastrin-releasing peptide (GRP) in various types of cancer suggest that GRP might be a putative target for immunotherapy in neoplastic diseases. DNA vaccine for hormone/growth factor immune deprivation represents a feasible and attractive approach for cancer treatment; nevertheless, there is still a need to increase the potency of the DNA vaccine. Here, based on six copies of the B cell epitope GRP(18-27) in a linear alignment as an immunogen, we designed several anti-GRP DNA vaccines containing different combinations of immunoadjuvants, such as HSP65, tetanus toxoid(830-844) (T), pan HLA-DR-binding epitope (PADRE) (P), and mycobacterial HSP70(407-426) (M), on a backbone of pCR3...
December 2009: Endocrine-related Cancer
Leonardo Vieira Neto, Evelyn de O Machado, Raul M Luque, Giselle F Taboada, Jorge B Marcondes, Leila M C Chimelli, Leonardo Pereira Quintella, Paulo Niemeyer, Denise P de Carvalho, Rhonda D Kineman, Mônica R Gadelha
CONTEXT: Dopamine receptor (DR) and somatostatin receptor subtype expression in pituitary adenomas may predict the response to postsurgical therapies. OBJECTIVES: Our objectives were to assess and compare the mRNA levels of DR1-5 and somatostatin receptors 1-5 in normal pituitaries (NPs), nonfunctioning pituitary adenomas (NFPAs), and somatotropinomas. In addition, we determined whether the level of DR expression correlates with the in vivo response to octreotide-LAR in acromegalic patients...
June 2009: Journal of Clinical Endocrinology and Metabolism
M L Jugan, L Oziol, M Bimbot, V Huteau, S Tamisier-Karolak, J P Blondeau, Y Lévi
The presence of estrogenomimetic compounds in the environment, and particularly in water resources, is well known. In contrast, little data is available about the disruption of the thyroid system, even though thyroid hormones are strongly involved in regulating metabolism, growth and development. The aim of this study was to carry out a parallel evaluation of the disruptions of thyroid and estrogenic hormone receptor transcriptional activities, induced by water samples from two wastewater treatment plants (WWTPs), in the river Seine, and from four drinking treatment plants located in the Paris area...
May 15, 2009: Science of the Total Environment
Sabine E Segerer, Nora Müller, Jens van den Brandt, Michaela Kapp, Johannes Dietl, Holger M Reichardt, Lorenz Rieger, Ulrike Kämmerer
BACKGROUND: Pregnancy represents an exclusive situation in which the immune and the endocrine system cooperate to prevent rejection of the embryo by the maternal immune system. While immature dendritic cells (iDC) in the early pregnancy decidua presumably contribute to the establishment of peripheral tolerance, glycoprotein-hormones of the transforming growth factor beta (TGF-beta) family including activin A (ActA) and inhibin A (InA) are candidates that could direct the differentiation of DCs into a tolerance-inducing phenotype...
2008: Reproductive Biology and Endocrinology: RB&E
Zhuohua Wang, Raul M Luque, Rhonda D Kineman, Vera H Ray, Konstantin T Christov, Daniel D Lantvit, Tomoyuki Shirai, Samad Hedayat, Terry G Unterman, Maarten C Bosland, Gail S Prins, Steven M Swanson
We asked whether down-regulation of GH signaling could block carcinogenesis in the Probasin/TAg rat, a model of aggressive prostate cancer. The Spontaneous Dwarf rat, which lacks GH due to a mutation (dr) in its GH gene, was crossed with the Probasin/TAg rat, which develops prostate carcinomas at 100% incidence by 15 wk of age. Progeny were heterozygous for the TAg oncogene and homozygous for either the wild-type GH gene (TAg/Gh(+/+)) or the dr mutation (TAg/Gh(dr/dr)). Prostate tumor incidence and burden were significantly reduced, and tumor latency was delayed in TAg/Gh(dr/dr) rats relative to TAg/Gh(+/+) controls...
March 2008: Endocrinology
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