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Michael A Samaan, Stacie I Ringleb, Sebastian Y Bawab, Eric K Greska, Joshua T Weinhandl
The effects of ACL-reconstruction on lower extremity joint mechanics during performance of the Star Excursion Balance Test (SEBT) and Single Leg Hop (SLH) are limited. The purpose of this study was to determine if altered lower extremity mechanics occur during the SEBT and SLH after ACL-reconstruction. One female Division I collegiate athlete performed the SEBT and SLH tasks, bilaterally, both before ACL injury and 27 months after ACL-reconstruction. Maximal reach, hop distances, lower extremity joint kinematics and moments were compared between both time points...
March 15, 2018: Computer Methods in Biomechanics and Biomedical Engineering
Jan Moritz Seliger, Livia Misuri, Edmund Maser, Jan Hintzpeter
Xanthohumol (XN), a prenylated chalcone unique to hops (Humulus lupulus) and two derived prenylflavanones, isoxanthohumol (IX) and 8-prenylnaringenin (8-PN) gained increasing attention as potential anti-diabetic and cancer preventive compounds. Two enzymes of the aldo-keto reductase (AKR) superfamily are notable pharmacological targets in cancer therapy (AKR1B10) and in the treatment of diabetic complications (AKR1B1). Our results show that XN, IX and 8-PN are potent uncompetitive, tight-binding inhibitors of human aldose reductase AKR1B1 (Ki  = 15...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
Lucas M Duarte, Luiz H C Adriano, Marcone A L de Oliveira
The precursor compounds related to the bitterness of beer are called α-acids. These compounds are extracted from the hop, which is an important ingredient in the brewing process. These compounds were analyzed by capillary electrophoresis. The electrophoretic method used 160 mmol L-1 of ammonium carbonate (pH 9) as BGE (background electrolyte), a voltage of + 20 kV in a capillary with 50 μm of internal diameter and with a 62.5 cm of total length (54 cm effective). The samples were injected in hydrodynamic mode applying a pressure of 25 mbar for 5 s and the analytes were detected at 230 nm...
March 6, 2018: Electrophoresis
Chris Bishop, Paul Read, Jermaine McCubbine, Anthony Turner
Inter-limb asymmetries have been shown to be greater during vertical jumping compared to horizontal jumping. Notable inter-limb differences have also been established at an early age in male youth soccer players. Furthermore, given the multi-planar nature of soccer, establishing between-limb differences from multiple jump tests is warranted. At present, a paucity of data exists regarding asymmetries in youth female soccer players and their effects on physical performance. The aims of this study were to quantify inter-limb asymmetries from unilateral jump tests and examine their effects on speed and jump performance...
February 27, 2018: Journal of Strength and Conditioning Research
Simone Schadt, Bojan Bister, Swapan K Chowdhury, Christoph Funk, Cornelis E C A Hop, W Griffith Humphreys, Fumihiko Igarashi, Alexander D James, Mark Kagan, S Cyrus Khojasteh, Angus N R Nedderman, Chandra Prakash, Frank Runge, Holger Scheible, Douglas K Spracklin, Piet Swart, Susanna Tse, Josh Yuan, R Scott Obach
Since the introduction of MIST guidance by FDA in 2008 there have been major changes in the experimental methods for the identification and quantification of metabolites, ways to evaluate coverage of metabolites, and the timing of critical clinical and non-clinical studies to generate these information. In this cross-industry article we discuss how the increased focus on human drug metabolites and their potential contribution to safety and drug-drug interactions has influenced the approaches taken by industry for the identification and quantitation of human drug metabolites...
February 27, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Michelle Ramirez, Rodney Negrete, William J Hanney, Morey J Kolber
Background: Two-dimensional (2D) analysis has the potential to identify individuals at risk for knee injury by measuring genu valgus during sport related tasks. The reliability of 2D mobile motion analysis in measuring genu valgus during a single leg hop test on individuals with anterior knee pain has not been examined. Purpose: To assess the reliability and concurrent validity of 2D mobile motion analysis and compare it to visual observation while analyzing dynamic genu valgus during a single leg hop test in subjects with anterior knee pain...
February 2018: International Journal of Sports Physical Therapy
Nicole Villafane-Ferriol, George Van Buren, Jose E Mendez-Reyes, Amy L McElhany, Nader N Massarweh, Eric J Silberfein, Cary Hsu, Hop S Tran Cao, Carl Schmidt, Nicholas J Zyromski, Mary E Dillhoff, Alexandra Roch, Evelyn Oliva, Alexander C Smith, Qianzi Zhang, William E Fisher
BACKGROUND: Although used as criterion for early drain removal, postoperative day (POD) 1 drain fluid amylase (DFA) ≤ 5000 U/L has low negative predictive value for clinically relevant postoperative pancreatic fistula (CR-POPF). It was hypothesized that POD3 DFA ≤ 350 could provide further information to guide early drain removal. METHODS: Data from a pancreas surgery consortium database for pancreatoduodenectomy and distal pancreatectomy patients were analyzed retrospectively...
February 23, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Matthew W Walker, Mario A Navarro, Leah Hoffman, Dana E Wagner, Carolyn A Stalgaitis, Jeffrey W Jordan
INTRODUCTION: Peer crowds, peer groups with macro-level connections and shared norms that transcend geography and race/ethnicity, have been linked to risky health behaviors. Research has demonstrated that Hip Hop peer crowd identification, which is common among multicultural youth, is associated with increased risk of tobacco use. To address this, the FDA Center for Tobacco Products created Fresh Empire, the first national tobacco education campaign tailored for Hip Hop youth aged 12-17 who are multicultural (Hispanic, African American, Asian-Pacific Islander, or Multiracial)...
February 10, 2018: Addictive Behaviors
Dai Sugimoto, Benton E Heyworth, Jeffery J Brodeur, Dennis E Kramer, Mininder S Kocher, Lyle J Micheli
CONTEXT: Recent epidemiology studies indicated a steady increase of anterior cruciate ligament (ACL) injury in young athletes. ACL reconstruction (ACLR) is currently a standard of the care, but effect of ACLR graft including bone patellar tendon bone (BTB), hamstring tendon (HT), or iliotibial band (ITB) on balance and hop performance is understudied. OBJECTIVE: To compare balance and hop deficits between uninvolved and reconstructed limbs in each autograft type (aim 1) and among the three autograft groups (aim 2)...
February 21, 2018: Journal of Sport Rehabilitation
Zeena Harakeh, Tom F M Ter Bogt
BACKGROUND: Music may influence young people's behavior through its lyrics. Substance use references occur more frequently in rap/hip-hop than in other music genres. OBJECTIVES: The aim was to examine whether the exposure to rap/hip-hop lyrics referring to substance use affected cigarette smoking. METHODS: An experiment with a 3-group between subject design was conducted among 74 daily-smoking young adults ranging in age from 17 to 25 years old...
February 16, 2018: Substance Use & Misuse
Praew Kotruchin, Satoshi Hoshide, Kazuomi Kario
The impact of a nondipping blood pressure (BP) pattern, defined as (awake systolic BP - sleep systolic BP)/awake systolic BP < 0.1, on cardiovascular events in populations with different degrees of carotid atherosclerosis is uncertain. The authors hypothesized that a nondipping BP pattern would show differential predictive power for cardiovascular events, including total cardiovascular death, sudden death, nonfatal cardiovascular events, and nonfatal stroke, between populations with and without carotid atherosclerosis...
February 16, 2018: Journal of Clinical Hypertension
S Ray, A Ghosh, S Sinha
Motivated by the recent experiment by Bordia et al. [Nat. Phys. 13, 460 (2017)NPAHAX1745-247310.1038/nphys4020], we study the single particle delocalization phenomena of the Aubry-André (AA) model subjected to periodic drives. In two distinct cases we construct an equivalent classical description to illustrate that the drive-induced delocalization phenomena stems from an instability and the onset of chaos in the underlying dynamics. In the first case we analyze the delocalization and the thermalization in a time modulated AA potential with respect to driving frequency and demonstrate that there exists a threshold value of the amplitude of the drive...
January 2018: Physical Review. E
Daan T van Yperen, Max Reijman, Eline M van Es, Sita M A Bierma-Zeinstra, Duncan E Meuffels
BACKGROUND: An anterior cruciate ligament (ACL) rupture has major consequences at midterm follow-up, with an increasing chance of developing an old knee in a young patient. The long-term (≥20 years) effects of the operative and nonoperative treatment of ACL ruptures are still unclear. PURPOSE: To compare the long-term treatment outcomes of operative versus nonoperative treatment of ACL ruptures in high-level athletes. STUDY DESIGN: Cohort study; Level of evidence, 2...
February 1, 2018: American Journal of Sports Medicine
Vala Flosadottir, Richard Frobell, Ewa M Roos, Eva Ageberg
BACKGROUND: In people with anterior cruciate ligament (ACL) injury, high self-efficacy facilitates recovery, indicated by improved muscle function, reduced knee symptoms and increased physical activity. Impact of treatment on future self-efficacy is however not well investigated. The aims of the study were to 1) investigate knee-related self-efficacy 6 years after acute ACL injury in patients treated with exercise therapy alone or in combination with either early or the option of delayed ACL reconstruction (ACLR), and 2) to investigate associations between single-leg physical performance at various time points after ACL injury and knee self-efficacy at 6 years after injury...
February 13, 2018: BMC Musculoskeletal Disorders
Annina E Zysset, Tanja H Kakebeeke, Nadine Messerli-Bürgy, Andrea H Meyer, Kerstin Stülb, Claudia S Leeger-Aschmann, Einat A Schmutz, Amar Arhab, Valentina Ferrazzini, Susi Kriemler, Simone Munsch, Jardena J Puder, Oskar G Jenni
Motor skills are interrelated with essential domains of childhood such as cognitive and social development. Thus, the evaluation of motor skills and the identification of atypical or delayed motor development is crucial in pediatric practice (e.g., during well-child visits). Parental reports on motor skills may serve as possible indicators to decide whether further assessment of a child is necessary or not. We compared parental reports on fundamental motor skills performance level (e.g., hopping, throwing), based on questions frequently asked in pediatric practice, with a standardized motor test in 389 children (46...
February 9, 2018: European Journal of Pediatrics
S Gore, A Franklyn-Miller, C Richter, E C Falvey, E King, K Moran
Athletic groin pain (AGP) is a common injury prevalent in field sports. One biomechanical measure that may be of importance for injury risk is stiffness. To date however, stiffness has not been examined in AGP. The primary aim was to determine if AGP affects vertical and joint stiffness and if so, whether successful rehabilitation is associated with a change in stiffness. Sixty-five male patients with AGP and fifty male controls were recruited to this study. Assessment included a biomechanical examination of stiffness during a lateral hurdle hop test...
February 9, 2018: Scandinavian Journal of Medicine & Science in Sports
Mathijs A M Suijkerbuijk, Max Reijman, Edwin H G Oei, Belle L van Meer, Ewoud R A van Arkel, Duncan E Meuffels
BACKGROUND: Semitendinosus and gracilis tendons may regenerate after harvesting for ligament reconstruction procedures. However, predictive factors of tendon regeneration and the extent of functional recovery remain unclear. PURPOSE: To identify predictive factors for hamstring tendon regeneration and to examine the morbidity of nonregenerated hamstring tendons. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Of the 154 patients who were included in a prospective follow-up study, 79 underwent reconstruction of the anterior cruciate ligament entailing the hamstring tendons and met the following inclusion criteria: (1) anterior cruciate ligament rupture diagnosed by physical examination and magnetic resonance imaging (MRI), (2) MRI within 6 months after trauma, (3) age between 18 and 45 years, and (4) 2-year follow-up MRI data available...
February 1, 2018: American Journal of Sports Medicine
J Chris Coetzee, J Kent Ellington, James A Ronan, Rebecca M Stone
BACKGROUND: The Broström procedure is the most commonly used lateral ligament repair for chronic instability, but there is concern about the strength of the repair and the risk of reinjury. Currently, the InternalBraceTM ligament augmentation repair is an accepted augmentation method for management of a Broström procedure. Our hypothesis was that augmentation of the Broström repair with an InternalBraceTM would allow accelerated rehabilitation and return to activity and would aid in stability of the repair without a tendency to stretch...
February 1, 2018: Foot & Ankle International
Tania Molina-Jiménez, Ofelia Limón-Morales, Herlinda Bonilla-Jaime
Administration of clomipramine (CMI), a tricyclic antidepressant, in early stages of development in rats, is considered an animal model for the study of depression. This pharmacological manipulation has induced behavioral and physiological alterations, i.e., less pleasure-seeking behaviors, despair, hyperactivity, cognitive dysfunction, alterations in neurotransmitter systems and in HPA axis. These abnormalities in adult male rats are similar to the symptoms observed in major depressive disorders. One of the main pleasure-seeking behaviors affected in male rats treated with CMI is sexual behavior...
January 31, 2018: Pharmacology, Biochemistry, and Behavior
Katerina Bogdanova, Magdalena Röderova, Milan Kolar, Katerina Langova, Martin Dusek, Petr Jost, Klara Kubelkova, Pavel Bostik, Jana Olsovska
Bacterial biofilms pose a serious medical problem due to their significant resistance to antimicrobials, and staphylococci are recognized as the most frequent cause of biofilm-associated infections. The hop plant (Humulus lupulus L.) contains substances that have been determined to act as anti-infective agents against bacteria, mainly in planktonic form. Therefore, we decided to investigate the antibiofilm properties of Humulus lupulus L.-derived compounds (humulone, lupulone and xanthohumol) against a selected group of Staphylococcus spp...
January 30, 2018: Research in Microbiology
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