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https://www.readbyqxmd.com/read/28087694/iso-%C3%AE-acids-bitter-components-of-beer-prevent-inflammation-and-cognitive-decline-induced-in-a-mouse-model-of-alzheimer-s-disease
#1
Yasuhisa Ano, Atsushi Dhata, Yoshimasa Taniguchi, Ayaka Hoshi, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayama
Alongside the rapid growth in aging populations worldwide, prevention and therapy for age-related memory decline and dementia are in great demand to maintain a long healthy life. Here we found that iso-α-acids, hop-derived bitter compounds in beer, enhance microglial phagocytosis and suppress inflammation via activation of the peroxisome proliferator-activated receptor (PPAR-γ). In normal mice, oral administration of iso-α-acids led to a significant increase both in CD11b and CD206 double-positive anti-inflammatory type microglia (P<0...
January 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28081034/the-effects-of-the-removal-of-electronic-devices-for-48-hours-on-sleep-in-elite-judo-athletes
#2
Ian C Dunican, David T Martin, Shona L Halson, Reid Reale, Brian Dawson, John Caldwell, Maddison J Jones, Peter R Eastwood
OBJECTIVE: This study examined the effects of the removal of electronic devices (i.e., smartphones, etc.) for 48 hours on sleep quality and next-day athletic and cognitive performance in elite Judo athletes. PARTICIPANTS: Over 6 days and nights, 23 eliteAustralian Judo athletes were monitored while attending a camp at the Australian Institute of Sport (AIS). In 14 athletes all electronic devices were removed on days 3 & 4 (i.e. for 48 hours: the 'device-restricted group') while 9 were permitted to use their devices throughout the camp (the 'control group')...
January 4, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28072630/bracing-of-the-reconstructed-and-osteoarthritic-knee-during-high-dynamic-load-tasks
#3
Harvi F Hart, Kay M Crossley, Natalie J Collins, David C Ackland
PURPOSE: Lateral compartment osteoarthritis accompanied by abnormal knee biomechanics are frequently reported in individuals with knee osteoarthritis after anterior cruciate ligament reconstruction (ACLR). The aim of this study was to evaluate changes in knee biomechanics produced by an adjusted and unadjusted varus knee brace during high dynamic loading activities in individuals with lateral knee osteoarthritis after ACLR and valgus malalignment. METHODS: Nineteen participants who had undergone ACLR 5 to 20 years previously and had symptomatic and radiographic lateral knee osteoarthritis with valgus malalignment were assessed...
January 9, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28070922/an-open-label-randomized-control-trial-of-hopping-and-jumping-training-versus-sensorimotor-rehabilitation-programme-on-postural-capacities-in-individuals-with-intellectual-disabilities
#4
Rihab Borji, Sonia Sahli, Rym Baccouch, Rabeb Laatar, Hiba Kachouri, Haithem Rebai
BACKGROUND: This study aimed to compare the effectiveness of a hopping and jumping training programme (HJP) versus a sensorimotor rehabilitation programme (SRP) on postural performances in children with intellectual disability. METHODS: Three groups of children with intellectual disability participated in the study: the HJP group, the SRP group and a control group. Postural capacities were tested with the Berg Balance Scale (BBS) and the Tinetti tests. The HJP and the SRP groups participated in the training programmes for eight weeks...
January 10, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28038341/standing-balance-and-inter-limb-balance-asymmetry-at-one-year-post-primary-anterior-cruciate-ligament-reconstruction-sex-differences-in-a-cohort-study-of-414-patients
#5
Ross A Clark, Stuart W Bell, Julian A Feller, Timothy S Whitehead, Kate E Webster
BACKGROUND: Static standing balance can be safely assessed early following anterior cruciate ligament reconstruction (ACLR), and deficits may have important implications for long-term outcomes. This study includes a large cohort of people post-ACLR and has the primary aim of establishing whether inter-limb and sex differences exist, with a secondary aim of assessing the association between static balance variables and other outcome measures. METHODS: A total of 414 patients with a primary ACLR performed a 30-s static single leg balance test...
December 16, 2016: Gait & Posture
https://www.readbyqxmd.com/read/28033483/bipedal-hopping-reveals-evidence-of-advanced-neuromuscular-aging-among-people-with-mild-multiple-sclerosis
#6
Megan C Kirkland, Matthew B Downer, Brett J Holloway, Elizabeth M Wallack, Evan J Lockyer, Natasha C M Buckle, Courtney L Abbott, Michelle Ploughman
Measures of walking such as the timed 25-ft walk test (T25FWT) may not be able to detect subtle impairment in lower limb function among people with multiple sclerosis (MS). We examined bipedal hopping to determine to what extent people with mild (Expanded Disease Severity Scale ≤ 3.5) MS (n = 13) would differ compared to age-, gender-, and education-matched controls (n = 9) and elderly participants (n = 13; ≥ 70 years old). We estimated lower limb power (e.g., hop length, velocity), consistency (e.g., variability of hop length, time), and symmetry (ratio of left to right foot)...
December 29, 2016: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28031754/assessing-reactive-strength-measures-in-jumping-and-hopping-using-the-optojump%C3%A2-system
#7
Robin Healy, Ian C Kenny, Andrew J Harrison
The aim of this study was to assess the concurrent validity of the Optojump™ system (Microgate, Bolzano, Italy) versus a force platform in the estimation of temporal and reactive strength measures. In two separate investigations, twenty physically active males performed double-leg and single-leg drop jumps from a box height of 0.3 m and a 10 s vertical bilateral hopping test. Contact time, flight time and total time (the sum of contact and flight time) were concurrently assessed during single and double-leg drop jumps and during hopping...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28029512/design-synthesis-and-biological-activity-of-4-imidazo-1-2-b-pyridazin-3-yl-1h-pyrazol-1-yl-phenylbenzamide-derivatives-as-bcr-abl-kinase-inhibitors
#8
Liming Hu, Tingting Cao, Yongjuan Lv, Yiming Ding, Leifu Yang, Qiang Zhang, Mingzhou Guo
A series of 4-((pyrazolo[1,5-a]pyrimidin-6-yl)-1H-pyrazol-1-yl)phenyl-3-benzamide derivatives and 4-((imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl-)phenyl-3-benzamide derivatives were designed, synthesized as new BCR-ABL tyrosine kinase inhibitors by using combinational strategies of scaffold hopping and conformational constraint. These new compounds were screened for BCR-ABL1 kinase inhibitory activity, and most of them appeared good inhibitory activity against BCR-ABL1 kinase. One of the most potent compounds 16a strongly suppressed BCR-ABL1 kinase with IC50 value of 8...
October 18, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28017899/nocodazole-treatment-interrupted-brucella-abortus-invasion-in-raw-264-7-cells-and-successfully-attenuated-splenic-proliferation-with-enhanced-inflammatory-response-in-mice
#9
Alisha Wehdnesday Bernardo Reyes, Huynh Tan Hop, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Wongi Min, Hu Jang Lee, Hong Hee Chang, Suk Kim
Brucellosis is one of the most important and widespread zoonosis worldwide responsible for serious economic losses and considerable public health burden. In this study, we investigated the modulatory effect of a microtubule-inhibitor, nocodazole, on B. abortus infection in murine macrophages and in a mouse model. Nocodazole activated macrophages and directly inhibited the growth of Brucella in a dose-dependent manner. Nocodazole increased adhesion but reduced invasion and intracellular growth of Brucella in macrophages although it did not affect co-localization of Brucella with LAMP-1...
December 23, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27998667/validity-and-reliability-of-a-novel-instrumented-one-legged-hop-test-in-patients-with-knee-injuries
#10
Karin Mani, William F Brechue, Bernd Friesenbichler, Nicola A Maffiuletti
BACKGROUND: Conventional one-legged hop tests simply evaluate the total hop distance, thus neglecting important temporal and spatial parameters related to the strategy of execution, such as foot contact time. AIM: To examine the validity and reliability of an instrumented one-legged hop test, the "four hops, three contacts" (4H3C) test, in patients with knee injuries. METHODS: The 4H3C test consists of four consecutive one-legged hops, of which individual hop distance and foot contact time are recorded by a validated floor-based photocell system...
December 17, 2016: Knee
https://www.readbyqxmd.com/read/27933908/can-a-topological-approach-predict-spin-symmetry-breaking-in-conjugated-hydrocarbons
#11
Jean-Paul Malrieu, Georges Trinquier
The closed-shell mean-field single determinants of large alternant hydrocarbons are frequently unstable with respect to a possible spin-symmetry breaking which produces different orbitals for the α and β electrons, either in Hartree-Fock or in Kohn-Sham DFT calculations. The present work shows that one may easily predict whether such a symmetry breaking will take place from the elementary topological Hückel Hamiltonian which introduces a simple hopping integral t. The demonstration makes use of the simplest representation of the bielectronic repulsion, namely, the Hubbard bielectronic operator, reduced to an on-site repulsion U, and takes benefit of the mirror theorem...
December 8, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27904797/preseason-jump-and-hop-measures-in-male-collegiate-basketball-players-an-epidemiologic-report
#12
Jason Brumitt, Amy Engilis, Dale Isaak, Amy Briggs, Alma Mattocks
BACKGROUND: Injuries are inherent in basketball with lower extremity (LE) injury rates reported as high as 11.6 per 1000 athletic exposures (AEs); many of these injuries result in time loss from sport participation. A recent trend in sports medicine research has been the attempt to identify athletes who may be at risk for injury based on measures of preseason fitness. HYPOTHESIS/PURPOSE: The purpose of this prospective cohort study was to determine if the standing long jump (SLJ) and/or the single-leg hop (SLH) for distance functional performance tests (FPT) are associated with non-contact time loss lower quadrant (LQ, defined as lower extremities or low back) injury in collegiate male basketball players...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27904796/functional-hop-tests-and-tuck-jump-assessment-scores-between-female-division-i-collegiate-athletes-participating-in-high-versus-low-acl-injury-prone-sports-a-cross-sectional-analysis
#13
Philipp Hoog, Meghan Warren, Craig A Smith, Nicole J Chimera
BACKGROUND: Although functional tests including the single leg hop (SLH), triple hop (TH), cross over hop (COH) for distance, and the tuck jump assessment (TJA) are used for return to play (RTP) criteria for post anterior cruciate ligament (ACL) injury, sport-specific baseline measurements are limited. PURPOSE: The purpose of this study was to examine differences in SLH, TH, and COH distance and limb symmetry index (LSI), as well as total scores, number of jumps, and individual flaws of the TJA in 97 injury-free Division I (DI) collegiate female student athletes participating in ACL injury prone vs...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27895509/effects-of-fentanyl-on-pain-and-motor-behaviors-following-a-collagenase-induced-intracerebral-hemorrhage-in-rats
#14
Laurence Saine, Pierre Hélie, Pascal Vachon
PURPOSE: Intracerebral hemorrhage (IH) and cephalalgia are common consequences of traumatic brain injury. One of the primary obstacles for patient recovery is the paucity of treatments to support an appropriate analgesic protocol. The present study aimed to assess pain and motor behaviors following different doses of fentanyl on a rat model of IH. METHODS: Twenty-one male Sprague Dawley rats underwent a stereotaxic surgery to produce a collagenase-induced IH in the right caudoputamen nucleus...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27895052/evidence-toads-may-modulate-landing-preparation-without-predicting-impact-time
#15
S M Cox, Gary Gillis
Within anurans (frogs and toads), cane toads (Bufo marinus) perform particularly controlled landings in which the forelimbs are exclusively used to decelerate and stabilize the body after impact. Here we explore how toads achieve dynamic stability across a wide range of landing conditions. Specifically, we suggest that torques during landing could be reduced by aligning forelimbs with the body's instantaneous velocity vector at impact (impact angle). To test whether toad forelimb orientation varies with landing conditions, we used high-speed video to collect forelimb and body kinematic data from six animals hopping off platforms of different heights (0, 5 and 9 cm)...
November 28, 2016: Biology Open
https://www.readbyqxmd.com/read/27893474/hypertrophy-and-explosive-reactive-functioning-in-sedentary-men-following-10-weeks-of-whole-body-vibration
#16
Jens Ebing, Ulf Gast, Christoph Hauptmann, Dieter Felsenberg, Daniel L Belavý
The objective of this study was to determine the impact of vertical (Power-plate; POW) and side-alternating (Galileo; GAL) whole-body vibration exercise on muscle mass and lower-limb neuromuscular function. Forty-three sedentary male subjects (18-30yr) randomized into three groups underwent two upper-body exercise sessions per week for 10 weeks. Two groups of subjects underwent additional squat exercises on the GAL (N=15) or POW (N=14) devices. The third group was control. On magnetic resonance imaging, volume of the thigh muscles was measured...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27890780/a-clinical-score-to-predict-appendicitis-in-older-male-children
#17
Anupam B Kharbanda, Michael C Monuteaux, Richard G Bachur, Nanette C Dudley, Lalit Bajaj, Michelle D Stevenson, Charles G Macias, Manoj K Mittal, Jonathan E Bennett, Kelly Sinclair, Peter S Dayan
OBJECTIVE: To develop a clinical score to predict appendicitis among older, male children who present to the emergency department (ED) with suspected appendicitis. METHODS: Patients with suspected appendicitis were prospectively recruited at 9 pediatric EDs. A total 2,625 patients enrolled; a subset of 961 males, age 8-18 were analyzed in this secondary analysis. Outcomes determined by pathology, operative reports and follow-up calls. Clinical and laboratory predictors with < 10% missing data and Kappa > 0...
November 24, 2016: Academic Pediatrics
https://www.readbyqxmd.com/read/27880888/evidence-of-a-different-landing-strategy-in-subjects-with-chronic-ankle-instability
#18
Christophe Eechaute, Roel De Ridder, Tom Maes, David Beckwée, Eva Swinnen, Ronald Buyl, Peter Vaes
The purpose of the study is to evaluate the discriminative validity of the multiple hop test (MHT) for chronic ankle instability (CAI). The dynamic postural control of 51 CAI subjects and 52 uninjured controls was assessed using the MHT. To evaluate dynamic postural control, the type and number of balance errors were analysed and the time to complete the MHT was measured. Between-group differences of time scores and balance errors, identified as being change-in-support strategy errors (CSS) or fixed-support strategy errors (FSS), were assessed...
November 2, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27872403/biomechanical-analysis-of-weighted-ball-exercises-for-baseball-pitchers
#19
Glenn S Fleisig, Alek Z Diffendaffer, Kyle T Aune, Brett Ivey, Walter A Laughlin
BACKGROUND: Weighted-ball throwing programs are commonly used in training baseball pitchers to increase ball velocity. The purpose of this study was to compare kinematics and kinetics among weighted-ball exercises with values from standard pitching (ie, pitching standard 5-oz baseballs from a mound). HYPOTHESIS: Ball and arm velocities would be greater with lighter balls and joint kinetics would be greater with heavier balls. STUDY DESIGN: Controlled laboratory study...
November 21, 2016: Sports Health
https://www.readbyqxmd.com/read/27866154/the-correlation-between-cognitive-and-movement-shifting-and-brain-activity-in-children-with-adhd
#20
Kyoung Doo Kang, Doug Hyun Han, Sun Mi Kim, Sujin Bae, Perry F Renshaw
OBJECTIVE: We assessed the correlation between the deficits of cognition, movement, and brain activity in children with Attention Deficit Hyperactvity Disorder (ADHD). METHOD: We recruited 15 children with ADHD and 15 age- and sex-matched healthy control participants. Clinical symptoms, cognitive shifting, movement shifting, and brain activity were assessed using the Korean ADHD Rating Scale, the Wisconsin Card Sorting Test (WCST), the 7- and 14-ring drill test with hop jumps (7 HJ and 14 HJ), and 3...
November 19, 2016: Journal of Attention Disorders
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