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https://www.readbyqxmd.com/read/27753898/os-01-07-clinical-importance-of-collagen-metabolism-markers-in-rheumatic-heart-valve-disease-in-indian-subpopulation
#1
Tanima Banerjee, Somaditya Mukherjee, Sudip Ghosh, Monodeep Biswas, Santanu Datta, Sanjib Pattari, Shelly Chatterjee, Arun Bandyopadhyay
OBJECTIVE: Rheumatic Heart Disease (RHD), a chronic acquired heart disorder results from Acute Rheumatic Fever. RHD is mostly prevalent in developing nations which is mainly diagnosed by transthoracic echocardiography. Till date, there is no biochemical marker for disease management. In the present study we aim to investigate whether mitral valve remodeling contributes to altered levels of circulating biomarkers of collagen metabolism in rheumatic heart disease. DESIGN AND METHOD: The study involved RHD subjects with before and after valve replacement surgery which includes age and sex matched controls...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643244/os-01-07-clinical-importance-of-collagen-metabolism-markers-in-rheumatic-heart-valve-disease-in-indian-subpopulation
#2
Tanima Banerjee, Somaditya Mukherjee, Sudip Ghosh, Monodeep Biswas, Santanu Datta, Sanjib Pattari, Shelly Chatterjee, Arun Bandyopadhyay
OBJECTIVE: Rheumatic Heart Disease (RHD), a chronic acquired heart disorder results from Acute Rheumatic Fever. RHD is mostly prevalent in developing nations which is mainly diagnosed by transthoracic echocardiography. Till date, there is no biochemical marker for disease management. In the present study we aim to investigate whether mitral valve remodeling contributes to altered levels of circulating biomarkers of collagen metabolism in rheumatic heart disease. DESIGN AND METHOD: The study involved RHD subjects with before and after valve replacement surgery which includes age and sex matched controls...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/26631842/ascorbic-acid-promotes-extracellular-matrix-deposition-while-preserving-valve-interstitial-cell-quiescence-within-3d-hydrogel-scaffolds
#3
Yan Wu, Daniel S Puperi, K Jane Grande-Allen, Jennifer L West
Current options for aortic valve replacements are non-viable and thus lack the ability to grow and remodel, which can be problematic for paediatric applications. Toward the development of living valve substitutes that can grow and remodel, porcine aortic valve interstitial cells (VICs) were isolated and encapsulated within proteolytically degradable and cell-adhesive poly(ethylene glycol) (PEG) hydrogels, in an effort to study their phenotypes and functions. The results showed that encapsulated VICs maintained high viability and proliferated within the hydrogels...
December 3, 2015: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/26443037/association-of-impaired-left-ventricular-twisting-untwisting-with-vascular-dysfunction-neurohumoral-activation-and-impaired-exercise-capacity-in-hypertensive-heart-disease
#4
Ignatios Ikonomidis, Stavros Tzortzis, Helen Triantafyllidi, John Parissis, Costas Papadopoulos, Kyriaki Venetsanou, Paraskevi Trivilou, Ioannis Paraskevaidis, John Lekakis
AIMS: We investigated the association between left ventricular (LV) torsional deformation and vascular dysfunction, fibrosis, neurohumoral activation, and exercise capacity in patients with normal ejection fraction METHODS AND RESULTS: In 320 newly-diagnosed untreated hypertensive patients and 160 controls, we measured: pulse wave velocity (PWV); coronary flow reserve (CFR) by Doppler echocardiography; global longitudinal strain and strain rate, peak twisting, the percentage changes between peak twisting, and untwisting at mitral valve opening (%dpTw - UtwMVO ), at peak (%dpTw - UtwPEF ), and the end of early LV diastolic filling (%dpTw - UtwEDF ) by speckle tracking imaging; transforming growth factor (TGFb-1), metalloproteinase-9 (MMP-9), tissue inhibitor of matrix metalloptoteinase-1(TIMP-1), markers of collagen synthesis, and N-terminal pro-brain natriuretic peptide (NT-proBNP)...
December 2015: European Journal of Heart Failure
https://www.readbyqxmd.com/read/26319699/matrix-metalloproteinases-as-regulators-of-vein-structure-and-function-implications-in-chronic-venous-disease
#5
REVIEW
Elisabeth MacColl, Raouf A Khalil
Lower-extremity veins have efficient wall structure and function and competent valves that permit upward movement of deoxygenated blood toward the heart against hydrostatic venous pressure. Matrix metalloproteinases (MMPs) play an important role in maintaining vein wall structure and function. MMPs are zinc-binding endopeptidases secreted as inactive pro-MMPs by fibroblasts, vascular smooth muscle (VSM), and leukocytes. Pro-MMPs are activated by various activators including other MMPs and proteinases. MMPs cause degradation of extracellular matrix (ECM) proteins such as collagen and elastin, and could have additional effects on the endothelium, as well as VSM cell migration, proliferation, Ca(2+) signaling, and contraction...
December 2015: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/26213589/heterogeneity-of-mitral-leaflet-matrix-composition-and-turnover-correlates-with-regional-leaflet-strain
#6
Elizabeth H Stephens, Patrick S Connell, Monica M Fahrenholtz, Tomasz A Timek, George T Daughters, Joyce J Kuo, Aaron M Patton, Neil B Ingels, D Craig Miller, K Jane Grande-Allen
To determine how extracellular matrix and contractile valvular cells contribute to the heterogeneous motion and strain across the mitral valve (MV) during the cardiac cycle, regional MV material properties, matrix composition, matrix turnover, and cell phenotype were related to regional leaflet strain. Radiopaque markers were implanted into 14 sheep to delineate the septal (SEPT), lateral (LAT), and anterior and posterior commissural leaflets (ANT-C, POST-C). Videofluoroscopy imaging was used to calculate radial and circumferential strains...
June 2015: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/26195991/cellular-and-extracellular-matrix-basis-for-heterogeneity-in-mitral-annular-contraction
#7
Elizabeth H Stephens, Monica M Fahrenholtz, Patrick S Connell, Tomasz A Timek, George T Daughters, Joyce J Kuo, Aaron M Patton, Neil B Ingels, D Craig Miller, K Jane Grande-Allen
PURPOSE: Regional heterogeneity in mitral annular contraction, which is generally ascribed to the fibrous vs. muscular annular composition, ensures proper leaflet motion and timing of coaptation. It is unknown whether the fibroblast-like cells in the annulus modulate this heterogeneity, even though valvular interstitial cells (VICs) can be mechanically "activated." METHODS: Fourteen sheep underwent implantation of radiopaque markers around the mitral annulus defining four segments: septal (SEPT), lateral (LAT), and anterior (ANT-C) and posterior (POST-C) commissures...
June 2015: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/25633835/reciprocal-interactions-between-mitral-valve-endothelial-and-interstitial-cells-reduce-endothelial-to-mesenchymal-transition-and-myofibroblastic-activation
#8
Kayle Shapero, Jill Wylie-Sears, Robert A Levine, John E Mayer, Joyce Bischoff
Thickening of mitral leaflets, endothelial-to-mesenchymal transition (EndMT), and activated myofibroblast-like interstitial cells have been observed in ischemic mitral valve regurgitation. We set out to determine if interactions between mitral valve endothelial cells (VECs) and interstitial cells (VICs) might affect these alterations. We used in vitro co-culture in Transwell™ inserts to test the hypothesis that VICs secrete factors that inhibit EndMT and conversely, that VECs secrete factors that mitigate the activation of VICs to a myofibroblast-like, activated phenotype...
March 2015: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/25390353/matrix-metalloproteinase-9-expression-in-calcified-human-aortic-valves-a-histopathologic-immunohistochemical-and-ultrastructural-study
#9
Ida Perrotta, Alfonso Sciangula, Saveria Aquila, Sergio Mazzulla
The hallmarks of calcific aortic valve disease (CAVD) are the significant quantitative and qualitative changes that occur in the extracellular matrix (ECM), which ultimately lead to increased leaflet stiffness and obstruction of left ventricular outflow. Mounting evidence suggests that ECM remodeling not only contribute to valve cell dysfunction but also alter certain cell signaling pathways responsible for the initiation and progression of the disease state. Matrix metalloproteinases (MMPs), collectively called matrixins, are a family of enzymes known to participate in numerous ECM remodeling events during embryonic development and in disease...
February 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/25308842/analysis-of-extracellular-superoxide-dismutase-and-akt-in-ascending-aortic-aneurysm-with-tricuspid-or-bicuspid-aortic-valve
#10
A Arcucci, M R Ruocco, F Albano, G Granato, V Romano, G Corso, C Bancone, E De Vendittis, A Della Corte, S Montagnani
Ascending aortic aneurysm (AsAA) is a consequence of medial degeneration (MD), deriving from apoptotic loss of smooth muscle cells (SMC) and fragmentation of elastin and collagen fibers. Alterations of extracellular matrix structure and protein composition, typical of medial degeneration, can modulate intracellular pathways. In this study we examined the relevance of superoxide dismutase (SOD3) and Akt in AsAA pathogenesis, evaluating their tissue distribution and protein levels in ascending aortic tissues from controls (n=6), patients affected by AsAA associated to tricuspid aortic valve (TAV, n=9) or bicuspid aortic valve (BAV, n=9)...
2014: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/24893666/gender-dependent-aortic-remodelling-in-patients-with-bicuspid-aortic-valve-associated-thoracic-aortic-aneurysm
#11
Jiwon Lee, Mengcheng Shen, Nirmal Parajuli, Gavin Y Oudit, Michael Sean McMurtry, Zamaneh Kassiri
UNLABELLED: An aortic aneurysm is characterized by widening of the aortic lumen diameter with adverse remodelling of the vascular extracellular matrix. A thoracic aortic aneurysm (TAA) is highly prevalent in patients with a bicuspid aortic valve (BAV). We investigated the structural remodelling in the aneurysmal ascending aorta in correlation to molecular alterations in male versus female BAV-TAA patients. Aneurysmal aortic samples (diameter >4.4 cm) from male and female patients were compared to non-aneurysmal non-BAV samples...
September 2014: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/24670922/a-novel-role-of-sympathetic-activity-in-regulating-mitral-valve-prolapse
#12
Xiang Hu, Hao-Zhe Wang, Jun Liu, An-Qin Chen, Xiao-Feng Ye, Qiang Zhao
BACKGROUND: Increased sympathetic activity, commonly reported in mitral valve prolapse, indicates that the sympathetic nervous system might play an important role in regulating mitral interstitial cells. Hence, the aim of this study is to determine the level and pattern of adrenergic receptors expressed in human mitral valve leaflets and to investigate the effect of norepinephrine on physiologic behaviors of mitral interstitial cells. METHODS AND RESULTS: Immunohistochemistry displayed significantly increased expressions of β1, β2, and α1 adrenergic receptors in mitral valve prolapse...
2014: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/24603967/clinical-significance-of-markers-of-collagen-metabolism-in-rheumatic-mitral-valve-disease
#13
Tanima Banerjee, Somaditya Mukherjee, Sudip Ghosh, Monodeep Biswas, Santanu Dutta, Sanjib Pattari, Shelly Chatterjee, Arun Bandyopadhyay
BACKGROUND: Rheumatic Heart Disease (RHD), a chronic acquired heart disorder results from Acute Rheumatic Fever. It is a major public health concern in developing countries. In RHD, mostly the valves get affected. The present study investigated whether extracellular matrix remodelling in rheumatic valve leads to altered levels of collagen metabolism markers and if such markers can be clinically used to diagnose or monitor disease progression. METHODOLOGY: This is a case control study comprising 118 subjects...
2014: PloS One
https://www.readbyqxmd.com/read/24481098/alternative-causes-of-bioreaction-to-prosthetic-heart-valves-three-cases-with-pannus-formation
#14
Su Leyman Karakoyun, Ozan Mustafa Gu Rsoy, Macit Kalçık, Sermin Coban Kökten, Mehmet Ozkan
Pannus formation is an infrequent but serious complication of prosthetic heart valve surgery. The cause of pannus is recognized as a bioreaction to the prostheses; histological investigations have shown that pannus comprises collagen and elastic tissues containing endothelial cells, chronic inflammatory cells, and myofibroblasts. However, the detailed mechanism of its formation has not been fully demonstrated. We aimed to evaluate the potential role of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) in the pathogenesis of pannus formation in three patients with mechanical prosthetic heart valves...
January 2014: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/24130082/role-of-cell-matrix-interactions-on-vic-phenotype-and-tissue-deposition-in-3d-peg-hydrogels
#15
Sarah T Gould, Kristi S Anseth
Valvular interstitial cells (VICs) respond to 3D matrix interactions in a complex manner, but understanding these effects on VIC function better is important for applications ranging from valve tissue engineering to studying valve disease. Here, we encapsulated VICs in poly(ethylene glycol) (PEG) hydrogels modified with three different adhesive ligands, derived from fibronectin (RGDS), elastin (VGVAPG) and collagen-1 (P15). By day 14, VICs became significantly more elongated in RGDS-containing gels compared to VGVAPG or P15...
October 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/23982279/heterogeneous-susceptibility-of-valve-endothelial-cells-to-mesenchymal-transformation-in-response-to-tnf%C3%AE
#16
Emily J Farrar, Jonathan T Butcher
Lack of understanding of the early mechanisms of aortic valve stenosis and calcification hinders the development of diagnostic and therapeutic intervention strategies. Inflammation is a known component of early aortic valve disease and can induce mesenchymal transformation in a subset of aortic valve endothelial cells. Here we present a three-dimensional culture system that allows transforming and non-transforming cells to be independently isolated and analyzed. We have used the system to identify and characterize the dynamic invasion and phenotypic transition of two distinct subsets of endothelial cells: those that invade and transform under TNFα treatment, and those that resist mesenchymal transformation and remain endothelial...
January 2014: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/23867576/the-role-of-matrix-metalloproteinase-2-in-the-treatment-of-atrial-fibrillation-recurrence-after-a-radiofrequency-modified-maze-procedure
#17
Xin Wang, Yuan Li, Lei Liu, Sheng-Shou Hu, Yun-Hu Song, Wei Wang
BACKGROUND AND OBJECTIVE: Our study aimed to elucidate the potential clinical and molecular issues in recurrent atrial fibrillation (AF) following a radiofrequency modified maze procedure in patients with rheumatic valvular disease and persistent AF. METHODS AND RESULTS: Eighty patients with rheumatic valvular disease and persistent AF (lasting more than 6 months) who had undergone a radiofrequency modified maze procedure and mitral valve replacement were enrolled into this single-center pilot study and were followed up for another 6 months...
2013: Cardiology
https://www.readbyqxmd.com/read/23658491/hydrogen-sulfide-and-sodium-nitroprusside-compete-to-activate-deactivate-mmps-in-bone-tissue-homogenates
#18
Thomas P Vacek, Natia Qipshidze, Suresh C Tyagi
BACKGROUND: Bone microvascular remodeling is the primary predictor of bone structure and function. Remodeling by its very nature implies synthesis and degradation of the extracellular matrix. Normally, 50% of total protein in the vessel wall is elastin. During remodeling, elastin is degraded by specialized matrix metalloproteinases (MMPs). Because the turnover of elastin is 1000-fold slower than that of collagen, most of the elastin is replaced by stiffer collagen. Stiffer vessels impose pressure on the aortic valve, causing regurgitation and increased pulse pressure...
2013: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/23454057/interactions-of-u937-macrophage-like-cells-with-decellularized-pericardial-matrix-materials-influence-of-crosslinking-treatment
#19
Jonathan K McDade, Ellen P Brennan-Pierce, Marianne B Ariganello, Rosalind S Labow, J Michael Lee
While macrophages have been implicated in the failure of bioprosthetic heart valves, the macrophage response to crosslinked native pericardial collagen has not been previously investigated. Using decellularized bovine pericardium (DBP) as a model for native collagen, this study investigated the response of macrophage-like cells (U937s) to DBP, either: (i) untreated, or (ii) exogenously crosslinked with glutaraldehyde or 1-ethyl-3-(3-dimethyl-aminopropyl)-carbodiimide (EDC). We have previously validated the use of U937 cells as models for the response of human monocyte-derived macrophages to decellularized pericardial materials and, per our previous work, differentiated the U937 cells directly on the three material surfaces...
July 2013: Acta Biomaterialia
https://www.readbyqxmd.com/read/23095015/matrix-metalloproteinase-2-and-9-levels-in-patients-with-dilated-ascending-aorta-and-bicuspid-aortic-valve
#20
COMPARATIVE STUDY
Okay Abaci, Cuneyt Kocas, Kadriye Orta Kilickesmez, Sinan Uner, Serdar Kucukoglu
BACKGROUND: Predictors of aortic dilatation are not well-described in patients with bicuspid aortic valve (BAV). Changes in extracellular matrix composition in the aortic wall may play an important role. Our study aimed to examine the relationship between ascending aortic dilatation and biochemical markers for collagen metabolism, such as matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) levels in patients with BAV. METHODS: All patients underwent cardiac echocardiography using a standard protocol, and aortic measurements were made in end-diastole...
February 2013: Echocardiography
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