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Bioresorbable scaffolds

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https://www.readbyqxmd.com/read/29243353/first-in-human-evaluation-of-the-vascular-biocompatibility-and-biomechanical-performance-of-a-novel-ultra-high-molecular-weight-amorphous-plla-bioresorbable-scaffold-in-the-absence-of-anti-proliferative-drugs-two-year-imaging-results-in-humans
#1
Miguel Moncada, Juan A Delgado, Antonio Colombo, Pawel Gasior, Kamal Ramzipoor, Alex Estrada, Chang Lee, Danny Dokko, Juan F Granada
OBJECTIVES: In this first-in-human study, we prospectively studied the vascular compatibility and mechanical performance of a novel bare ultra-high molecular weight amorphous PLLA bioresorbable scaffold (BRS, FORTITUDE®, Amaranth Medical, Mountain View, California) up to two years after implantation using multimodality imaging techniques. BACKGROUND: The vascular biocompatibility of polymers used in BRS has not been fully characterized in the absence of anti-proliferative drugs...
December 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29241467/-bioresorbable-coronary-scaffolds-follow-up
#2
J Elias, J J Piek
Bioresorbable scaffolds have been developed as an alternative to current metal stents. Despite earlier acceptable short-term results, the recently published AIDA study found that the most-used resorbable scaffold (Absorb) presents an almost threefold increased risk of stent thrombosis than the metal XIENCE stent, short-term as well as long-term. Acute and subacute stent thrombosis probably occur because of inadequate dual antiplatelet therapy, suboptimal implantation technique or both. Late stent thrombosis is probably affected by absorption-related stent-strut discontinuity and factors affecting blood flow...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29235306/comparison-of-everolimus-eluting-bioresorbable-vascular-scaffolds-and-metallic-stents-three-year-clinical-outcomes-from-the-absorb-china-randomised-trial
#3
Bo Xu, Yuejin Yang, Yaling Han, Yong Huo, Lefeng Wang, Xiangqian Qi, Jifu Li, Yundai Chen, Hai-Chien Kuo, Shih-Wa Ying, Wai-Fung Cheong, Yunlong Zhang, Xiaolu Su, Jeffery Popma, Runlin Gao, Gregg Stone
Aims: Absorb bioresorbable vascular scaffolds (BVS) and XIENCE cobalt-chromium everolimus-eluting stents (CoCr-EES) had comparable angiographic and clinical outcomes up to one year in patients enrolled in the ABSORB China randomised trial. Whether these favourable results with BVS continue beyond one year up to three years is unknown. In this study we sought to analyse the outcomes from the trial up to three-year follow-up. Methods and results: ABSORB China was a prospective, open-label, multicentre trial in which 480 patients with one or two native coronary artery lesions were randomised 1:1 to BVS (N=241) vs...
October 22, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29223378/bioresorbable-vascular-scaffold-thrombosis-clinical-and-optical-coherence-tomography-findings
#4
Javier Cuesta, Marcos García-Guimaraes, Teresa Basante, Fernando Rivero, Paula Antuña, Fernando Alfonso
No abstract text is available yet for this article.
December 6, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29223376/optical-coherence-tomography-of-magnesium-bioresorbable-scaffold-restenosis
#5
Sergio García-Blas, Gema Miñana, Juan Sanchis
No abstract text is available yet for this article.
December 6, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29217000/early-and-late-bioresorbable-vascular-scaffold-thrombosis-size-matters
#6
EDITORIAL
Manrique Alvarez, Robert J Applegate
No abstract text is available yet for this article.
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29216999/characteristics-predictors-and-mechanisms-of-thrombosis-in%C3%A2-coronary-bioresorbable-scaffolds-differences-between-early-and-late-events
#7
Tommaso Gori, Melissa Weissner, Svenja Gönner, Franziska Wendling, Helen Ullrich, Stephen Ellis, Remzi Anadol, Alberto Polimeni, Thomas Münzel
OBJECTIVES: The study sought to investigate the incidence, characteristics, predictors, and possible mechanisms of early and 3-year coronary scaffold thrombosis (ScT). BACKGROUND: An increased incidence of both early and late ScT has been shown in randomized trials. METHODS: Consecutive patients were enrolled in a single-center registry. Quantitative coronary angiography was performed. Incidence and predictors of ScT were assessed with Kaplan-Meier and Cox regression analyses...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29216998/bioresorbable-scaffolds-a-complex-journey-to-the-promised-land
#8
EDITORIAL
Antonio Colombo, Lorenzo Azzalini
No abstract text is available yet for this article.
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29216997/the-state-of-the-absorb-bioresorbable%C3%A2-scaffold-consensus-from-an-expert-panel
#9
REVIEW
Sripal Bangalore, Hiram G Bezerra, David G Rizik, Ehrin J Armstrong, Bruce Samuels, Srihari S Naidu, Cindy L Grines, Malcolm T Foster, James W Choi, Barry D Bertolet, Atman P Shah, Rebecca Torguson, Surendra B Avula, John C Wang, James P Zidar, Aziz Maksoud, Arun Kalyanasundaram, Steven J Yakubov, Bassem M Chehab, Anthony J Spaedy, Srini P Potluri, Ronald P Caputo, Ashok Kondur, Robert F Merritt, Amir Kaki, Ramon Quesada, Manish A Parikh, Catalin Toma, Fadi Matar, Joseph DeGregorio, William Nicholson, Wayne Batchelor, Raghava Gollapudi, Ethan Korngold, Riyaz Sumar, George S Chrysant, Jun Li, John B Gordon, Rajesh M Dave, Guilherme F Attizzani, Tom P Stys, Osvaldo S Gigliotti, Bruce E Murphy, Stephen G Ellis, Ron Waksman
Significant progress has been made in the percutaneous coronary intervention technique from the days of balloon angioplasty to modern-day metallic drug-eluting stents (DES). Although metallic stents solve a temporary problem of acute recoil following balloon angioplasty, they leave behind a permanent problem implicated in very late events (in addition to neoatherosclerosis). BRS were developed as a potential solution to this permanent problem, but the promise of these devices has been tempered by clinical trials showing increased risk of safety outcomes, both early and late...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29191384/the-effect-of-bioresorbable-vascular-scaffold-implantation-on-distal-coronary-endothelial-function-in-dyslipidemic-swine-with-and-without-diabetes
#10
Mieke van den Heuvel, Oana Sorop, Nienke S van Ditzhuijzen, René de Vries, Richard W B van Duin, Ilona Krabbendam-Peters, Janine E van Loon, Moniek P de Maat, Heleen M van Beusekom, Wim J van der Giessen, A H Jan Danser, Dirk J Duncker
BACKGROUND: We studied the effect of bioresorbable vascular scaffold (BVS) implantation on distal coronary endothelial function, in swine on a high fat diet without (HFD) or with diabetes (DM+HFD). METHODS: Five DM+HFD and five HFD swine underwent BVS implantation on top of coronary plaques, and were studied six months later. Conduit artery segments >5mm proximal and distal to the scaffold and corresponding control segments of non-scaffolded coronary arteries, as well as segments of small arteries within the flow-territories of scaffolded and non-scaffolded arteries were harvested for in vitro vasoreactivity studies...
November 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29190531/effect-of-two-year-degradation-on-mechanical-interaction-between-a-bioresorbable-scaffold-and-blood-vessel
#11
T Qiu, R He, C Abunassar, S Hossainy, L G Zhao
This paper aims to evaluate the mechanical behaviour of a bioresorbable polymeric coronary scaffold using finite element method, focusing on scaffold-artery interaction during degradation and vessel remodelling. A series of nonlinear stress-strain responses was constructed to match the experimental measurement of radial stiffness and strength for polymeric scaffolds over 2-year in-vitro degradation times. Degradation process was modelled by incorporating the change of material property as a function of time...
November 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29180778/the-development-of-bioresorbable-composite-polymeric-implants-with-high-mechanical-strength
#12
Upma Sharma, Danny Concagh, Lee Core, Yina Kuang, Changcheng You, Quynh Pham, Greg Zugates, Rany Busold, Stephanie Webber, Jonathan Merlo, Robert Langer, George M Whitesides, Maria Palasis
Implants for the treatment of tissue defects should mimic the mechanical properties of the native tissue of interest and should be resorbable as well as biocompatible. In this work, we developed a scaffold from variants of poly(glycolic) acid which were braided and coated with an elastomer of poly(glycolide-co-caprolactone) and crosslinked. The coating of the scaffold with the elastomer led to higher mechanical strength in terms of compression, expansion and elasticity compared to braids without the elastomer coating...
November 20, 2017: Nature Materials
https://www.readbyqxmd.com/read/29174242/bioresorbable-scaffold-fourth-revolution-or-failed-revolution-is-low-scaffold-strut-thickness-the-wrong-target
#13
EDITORIAL
Sundeep Mishra
Bioresorbable scaffold (BRS) technology has currently fallen into disrepute because of inordinately high risk of scaffold thrombosis and post-procedure myocardial infarction. Low tensile and radial strengths of polymeric BRS contributing to improper strut embedment have been identified as major correlates of poor outcomes following BRS implantation. Magnesium has a better tensile/radial strength compared with polymeric BRS but it is still far lower than cobalt-chromium. Newers innovations utilizing alteration in polymer composition and orientation or even newer polymers have focused on attempts to reduce strut thickness but may have little effect on tensile/radial strength of finished product and therefore may not impact the BRS outcome on long run...
November 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29171715/restenosis-patterns-after-bioresorbable-vascular-scaffold-implantation-angiographic-substudy-of-the-ghost-eu-registry
#14
Moritz Baquet, Holger Nef, Tomasso Gori, Azeem Latib, Davide Capodanno, Carlo Di Mario, Manel Sabate, Antonio Colombo, Corrado Tamburino, Julinda Mehilli
OBJECTIVES: To evaluate pattern of in-BVS-restenosis after bioresorbable vascular scaffold (BVS) implantation. BACKGROUND: In-stent restenosis morphology impacts target lesion revascularization (TLR) rates and clinical outcomes. Although several trials report on outcomes after BVS implantation, information about in-BVS restenosis pattern is still lacking. METHODS: Between November 2011 and January 2014, in 7 of 10 European centers participating in the GHOST-EU registry, 668 patients underwent BVS implantation...
November 24, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29171214/bioresorbable-vascular-scaffold-korean-expert-panel-report
#15
REVIEW
Jung Min Ahn, Duk Woo Park, Sung Jin Hong, Young Keun Ahn, Joo Yong Hahn, Won Jang Kim, Soon Jun Hong, Chang Wook Nam, Do Yoon Kang, Seung Yul Lee, Woo Jung Chun, Jung Ho Heo, Deok Kyu Cho, Jin Won Kim, Sung Ho Her, Sang Wook Kim, Sang Yong Yoo, Myeong Ki Hong, Seung Jea Tahk, Kee Sik Kim, Moo Hyun Kim, Yangsoo Jang, Seung Jung Park
Bioresorbable vascular scaffold (BRS) is an innovative device that provides structural support and drug release to prevent early recoil or restenosis, and then degrades into nontoxic compounds to avoid late complications related with metallic drug-eluting stents (DESs). BRS has several putative advantages. However, recent randomized trials and registry studies raised clinical concerns about the safety and efficacy of first generation BRS. In addition, the general guidance for the optimal practice with BRS has not been suggested due to limited long-term clinical data in Korea...
November 6, 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29168541/evaluation-of-bioresorbable-vascular-scaffolds-in-acute-coronary-syndrome-a-two-center-one-year-follow-up-analysis
#16
Sylwia Iwańczyk, Jarosław Hiczkiewicz, Aleksander Araszkiewicz, Magdalena Łanocha, Daria Adamczak, Wojciech Faron, Stefan Grajek, Maciej Lesiak
BACKGROUND: Bioresorbable vascular scaffolds (BVS) have emerged as a new treatment option in cardiovascular medicine. Nonetheless, there is still limited data on the use of these novel devices in patients with acute coronary syndromes (ACS). The purpose of this study was to evaluate the feasibility and efficacy of BVS implantation in patients with ACS. METHODS: The present report is a prospective, two-centre registry that involved 165 consecutive patients hospitalized with the diagnosis of ACS and treated with the Absorb BVS (Abbot Vascular, Santa Clara, USA)...
November 23, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29167623/bioresorbable-vascular-scaffold-stent-delivered-to-tortuous-lesions-by-using-the-five-in-six-system
#17
Wen-Jung Chung, Hsiu-Yu Fang, Chiung-Jen Wu
A 5Fr ST01, which is a straight-tip guiding catheter with an inner lumen of 1.5 mm, is frequently used to perform the "child-in-mother" technique, which is also referred to as the "5-in-6" technique. A 6Fr or larger size guiding catheter can facilitate bioresorbable everolimus-eluting vascular scaffold (BVS) delivery. For tortuous lesions, the 5-in-6 technique can facilitate balloon catheters and the BVS in crossing tortuous lesions by increasing the back-up support. However, this maneuver couldn't be used for the larger size of BVS like 3...
November 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29167614/thirty-day-and-one-year-clinical-outcomes-of-bioresorbable-vascular-scaffold-implantation-a-single-center-experience
#18
Wei-Chieh Lee, Chiung-Jen Wu, Chien-Jen Chen, Cheng-Hsu Yang, Shu-Kai Hsueh, Hon-Kan Yip, Chi-Ling Hang, Chih-Yuan Fang, Hsiu-Yu Fang
Background: Available data on the use of the Bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, CA) in real-world patients is limited, particularly in Asian populations. The aim of this study was to assess clinical outcomes of patients treated with a BVS in real-world practice in Taiwan. Methods: This study focused on 156 patients with coronary artery disease and a total of 249 lesions who received BVS implantation from October 2012 to October 2015...
November 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29164531/biphasic-bioresorbable-scaffold-trufit-%C3%A2-in-knee-osteochondral-defects-3-t-mri-evaluation-of-osteointegration-in-patients-with-a-5-year-minimum-follow-up
#19
G Bugelli, F Ascione, G Dell'Osso, V Zampa, S Giannotti
PURPOSE: The aim of this study is to follow morphological imaging characteristics and osteointegration of TruFit(®) bone graft substitute (BGS) plugs in cases of chondral and osteochondral defects of the articular surface of the knee joint, using high-quality cartilage-sensitive 3-T magnetic resonance imaging (MRI), linked to clinical outcomes. METHODS: The MRI was used to assess osteointegration and biological evolution of the TruFit(®) BGS plugs in cases with minimum 5-year follow-up: The TruFit(®) plug was used in 46 patients for a total of 47 cases with mean age of 57...
November 21, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29160048/from-biodegradable-polymers-to-bioresorbable-vascular-scaffolds-available-evidence-in-the-current-era-of-new-generation-des
#20
Fabio Magliulo, Raffaele Piccolo, Anna Franzone, Giovanni Esposito, Gian B Danzi
New-generation drug-eluting stents (DES) encompass a large variety of coronary devices, featuring thin struts, biocompatible durable or biodegradable polymer coatings, and limus-eluting drugs. Due to improved early and long-term outcomes among patients undergoing percutaneous coronary intervention, new-generation metallic DES are recommended in almost all patient and lesion subsets. Available evidence from randomized trials indicate a similar safety and efficacy profile between biodegradable and durable polymers new-generation DES...
November 20, 2017: Minerva Cardioangiologica
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