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https://www.readbyqxmd.com/read/28650485/neuroblastoma-is-composed-of-two-super-enhancer-associated-differentiation-states
#1
Tim van Groningen, Jan Koster, Linda J Valentijn, Danny A Zwijnenburg, Nurdan Akogul, Nancy E Hasselt, Marloes Broekmans, Franciska Haneveld, Natalia E Nowakowska, Johannes Bras, Carel J M van Noesel, Aldo Jongejan, Antoine H van Kampen, Linda Koster, Frank Baas, Lianne van Dijk-Kerkhoven, Margriet Huizer-Smit, Maria C Lecca, Alvin Chan, Arjan Lakeman, Piet Molenaar, Richard Volckmann, Ellen M Westerhout, Mohamed Hamdi, Peter G van Sluis, Marli E Ebus, Jan J Molenaar, Godelieve A Tytgat, Bart A Westerman, Johan van Nes, Rogier Versteeg
Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has sparked an interest in their epigenetic regulation. Several tumor types include phenotypically divergent cells, resembling cells from different lineage development stages. It has been proposed that super-enhancer-associated transcription factor (TF) networks underlie lineage identity, but the role of these enhancers in intratumoral heterogeneity is unknown. Here we show that most neuroblastomas include two types of tumor cells with divergent gene expression profiles...
June 26, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28650185/sexual-misconduct-in-prison-what-factors-affect-whether-incarcerated-women-will-report-abuses-committed-by-prison-staff
#2
Sheryl P Kubiak, Hannah J Brenner, Deborah Bybee, Rebecca Campbell, Cristy E Cummings, Kathleen M Darcy, Gina Fedock, Rachael Goodman-Williams
More than 80,000 prisoners each year are sexually victimized during incarceration, but only about 8% report victimization to correctional authorities. Complicating reporting is the fact that half of the perpetrators are staff members. Given the restrictive and highly regulated prison environment, studies that examine reporting behaviors are difficult to conduct and to date information available relied on those who have reported or hypothetical victimization studies. This study uses an ecological framework and archival data from a class action lawsuit of sexual misconduct to determine predictors of reporting...
June 26, 2017: Law and Human Behavior
https://www.readbyqxmd.com/read/28649869/hivr4p-2016-partnering-for-prevention-conference-summary-and-highlights
#3
Barbara L Shacklett, Cynthia A Derdeyn, Morenike Oluwatoyin Folayan, Raphael Landovitz, Colin Anthony, Anna-Janina Behrens, Thomas Hope, Elise Landais, Lorna Leal, Jeanne M Marrazzo, Lynn Morris, Nelly Mugo, Kenneth Ngure, Veronica Noseda, Srinika Ranasinghe, Damien C Tully, Yegor Voronin, Mitchell Warren, Constantinos Kurt Wibmer, Irene Y Xie, Gabriella Scarlatti, Bargavi Thyagarajan
HIV Research for Prevention: AIDS Vaccine, Microbicide and ARV-based Prevention Science (HIVR4P) was built upon a growing consensus that effective HIV prevention requires a combination of approaches and that understanding, analyzing and debating the cross-cutting issues that impact prevention research are all essential to combat the global HIV/AIDS epidemic. To that end, the biennial HIVR4P conference is dedicated to all biomedical HIV prevention research approaches, including HIV vaccines, microbicides, PrEP and treatment as prevention...
June 24, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28649629/rhogtpase-stimulation-is-associated-with-strontium-chloride-treatment-to-counter-simulated-microgravity-induced-changes-in-multipotent-cell-commitment
#4
Fiona Louis, Wafa Bouleftour, Aline Rattner, Marie-Thérèse Linossier, Laurence Vico, Alain Guignandon
Microgravity-related cytoskeletal disorganization is associated with an altered balance between osteoblastogenesis and adipogenesis of multipotent cells. Strontium chloride is known to increase osteoblastogenesis and repress adipogenesis, but its effects in microgravity-related conditions have not been established. Our goal was to investigate early events in this process, focusing on RhoGTPases as controllers of cytoskeletal organization leading to stem cell commitment. We cultivated C3H10T1/2 on microspheres using a rotating wall vessel bioreactor (NASA) in order to simulate microgravity-related conditions in adipogenesis and osteoblastogenesis conditions independently...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28648970/treating-functional-non-epileptic-attacks-should-we-consider-acceptance-and-commitment-therapy
#5
REVIEW
Sarah R Cope, Norman Poole, Niruj Agrawal
Patients who experience functional non-epileptic attacks (FNEA) are frequently seen in Neurology clinics. Diagnosis alone can result in cessation of attacks for some patients, but many patients require further treatment. There is evidence that certain psychological therapies, like cognitive-behavioral therapy (CBT) and psychodynamic interpersonal therapy (PIT) can be beneficial. Acceptance and commitment therapy (ACT) is a type of CBT that has been found to be effective at treating other somatic disorders, like epilepsy and chronic pain...
June 22, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28648899/transient-hes5-activity-instructs-mesodermal-cells-toward-a-cardiac-fate
#6
Ana G Freire, Avinash Waghray, Francisca Soares-da-Silva, Tatiana P Resende, Dung-Fang Lee, Carlos-Filipe Pereira, Diana S Nascimento, Ihor R Lemischka, Perpétua Pinto-do-Ó
Notch signaling plays a role in specifying a cardiac fate but the downstream effectors remain unknown. In this study we implicate the Notch downstream effector HES5 in cardiogenesis. We show transient Hes5 expression in early mesoderm of gastrulating embryos and demonstrate, by loss and gain-of-function experiments in mouse embryonic stem cells, that HES5 favors cardiac over primitive erythroid fate. Hes5 overexpression promotes upregulation of the cardiac gene Isl1, while the hematopoietic regulator Scl is downregulated...
June 21, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28648228/great-british-medalists-psychosocial-biographies-of-super-elite-and-elite-athletes-from-olympic-sports
#7
Lew Hardy, Matthew Barlow, Lynne Evans, Tim Rees, Tim Woodman, Chelsea Warr
Participants were 32 former GB athletes from Olympic sports, 16 Super-Elite athletes who had won multiple medals at major championships, and 16 matched Elite athletes who had not. In-depth interviews with the athletes, their coaches, and one of their parents explored all psychosocial aspects of their development and careers. Content analyses revealed that there were no differences between Super-Elite and Elite athletes with regard to family values, conscientiousness, or commitment to training. However, the two groups were found to be different with regard to: (1) the experience of a foundational negative life event coupled with a foundational positive sport-related event; (2) the experience of a career turning point that enhanced motivation and focus for their sport; (3) need for success; (4) obsessiveness and/or perfectionism with regard to training and performance; (5) ruthlessness and/or selfishness in the pursuit of their sporting goals; (6) dual focus on both mastery and outcome; (7) the use of counterphobic attitudes and/or total preparation to maintain higher levels of performance under pressure; and (8) the relative importance of sport over other aspects of life...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/28646947/measles-immune-suppression-and-vaccination-direct-and-indirect-nonspecific-vaccine-benefits
#8
Michael J Mina
The measles virus is among the most transmissible viruses known to infect humans. Prior to measles vaccination programs, measles infected over 95% of all children and was responsible for over 4 million deaths each year. Measles vaccination programs have been among the greatest public health achievements reducing, eliminating endemic measles in the whole of the Americas and across much of the globe. Where measles vaccines are introduced, unexpectedly large reductions in all-cause childhood mortality have been observed...
June 2017: Journal of Infection
https://www.readbyqxmd.com/read/28646878/achieving-sustainability-in-health-information-systems-a-field-tested-measure-of-country-ownership
#9
Stephanie Watson-Grant, Khou Xiong, James C Thomas
BACKGROUND: A country will trust, value, and use, its health information system (HIS) to the extent it has had a role in its creation and maintenance. A sense of ownership contributes in turn to the long-term sustainability of the HIS, and thus the country's ability to monitor and evaluate population health and health services. To facilitate progress toward greater ownership, we developed and tested a tool to measure the country's ownership of its monitoring and evaluation (M&E) system...
June 24, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28646471/decoding-early-myelopoiesis-from-dynamics-of-core-endogenous-network
#10
Hang Su, Gaowei Wang, Ruoshi Yuan, Junqiang Wang, Ying Tang, Ping Ao, Xiaomei Zhu
A decade ago mainstream molecular biologists regarded it impossible or biologically ill-motivated to understand the dynamics of complex biological phenomena, such as cancer genesis and progression, from a network perspective. Indeed, there are numerical difficulties even for those who were determined to explore along this direction. Undeterred, seven years ago a group of Chinese scientists started a program aiming to obtain quantitative connections between tumors and network dynamics. Many interesting results have been obtained...
May 29, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28646399/mousetrap-an-integrated-open-source-mouse-tracking-package
#11
Pascal J Kieslich, Felix Henninger
Mouse-tracking - the analysis of mouse movements in computerized experiments - is becoming increasingly popular in the cognitive sciences. Mouse movements are taken as an indicator of commitment to or conflict between choice options during the decision process. Using mouse-tracking, researchers have gained insight into the temporal development of cognitive processes across a growing number of psychological domains. In the current article, we present software that offers easy and convenient means of recording and analyzing mouse movements in computerized laboratory experiments...
June 23, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28646105/the-glycolytic-enzyme-phosphofructokinase-1-assembles-into-filaments
#12
Bradley A Webb, Anne M Dosey, Torsten Wittmann, Justin M Kollman, Diane L Barber
Despite abundant knowledge of the regulation and biochemistry of glycolytic enzymes, we have limited understanding on how they are spatially organized in the cell. Emerging evidence indicates that nonglycolytic metabolic enzymes regulating diverse pathways can assemble into polymers. We now show tetramer- and substrate-dependent filament assembly by phosphofructokinase-1 (PFK1), which is considered the "gatekeeper" of glycolysis because it catalyzes the step committing glucose to breakdown. Recombinant liver PFK1 (PFKL) isoform, but not platelet PFK1 (PFKP) or muscle PFK1 (PFKM) isoforms, assembles into filaments...
June 23, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28644696/varicella-vaccination-the-global-experience
#13
Peter Wutzler, Paolo Bonanni, Margaret Burgess, Anne Gershon, Marco Aurélio Sáfadi, Giacomo Casabona
Introduction Varicella, although a frequently benign childhood disease, nevertheless represents a considerable health burden. WHO recommends including varicella vaccines in universal routine vaccination programs, and maintaining coverage >80%. Many countries have successfully introduced varicella vaccination and have benefited from lower disease burden, but many others have not adopted the vaccine. Reasons include cost commitment for a 'mild childhood disease' or concerns that vaccination will shift varicella to older age groups or increase herpes zoster incidence...
June 23, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28644427/mental-diseases-and-criminal-offences-committed-by-persons-placed-at-the-forensic-department-of-the-penitentiary-in-zenica-federation-of-bosnia-and-herzegovina
#14
Edin Bjelošević, Adisa Krehmić, Halima Hadžikapetanović, Sanel Čoralić, Sonja Bjelošević
Aim To investigate an impact of various biological, psychological and social factors on perpetration of criminal offences by persons with mental disorders and to examine legal requirements for placement of persons with mental disorders, who committed criminal offences. Methods This retrospective, descriptive study based on the analysis of data collected from records of the Zenica Penitentiary, Forensic Department (age, qualifications, employment status, marital status, mental disorders, information related to earlier treatments, type of committed criminal offense, duration of the security measure of mandatory psychiatric treatment and custody) included 154 examinees...
August 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28642420/kiss-and-run-or-a-full-commitment
#15
EDITORIAL
Leslie K Ferrarelli
No abstract text is available yet for this article.
June 23, 2017: Science
https://www.readbyqxmd.com/read/28641977/a-novel-fluorescent-probe-reveals-starvation-controls-the-commitment-of-amyloid-precursor-protein-to-the-lysosome
#16
Leanne K Hein, Pirjo M Apaja, Kathryn Hattersley, Randall H Grose, Jianling Xie, Christopher G Proud, Timothy J Sargeant
Alzheimer's disease is the most important cause of dementia but there is no therapy that has been demonstrated to stop or slow disease progression. Amyloid precursor protein (APP) is the source of amyloid-β (Aβ), which aggregates in Alzheimer's disease to form toxic oligomeric species. The endo-lysosomal system can clear APP and Aβ from the cell if these molecular species are trafficked through to the lysosome. Currently, there are no easy methods available for the analysis of lysosomal APP trafficking. We therefore generated a fusion protein (tandem-fluorescent, or tf-APP) that allows detection of changes in APP trafficking using accessible techniques such as flow cytometry...
June 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28641960/-involuntary-commitment-of-the-psychiatric-patient-legal-regulations-and-critical-aspects
#17
M Ibáñez Bernáldez, M Casado Blanco
Traditionally, medical care received by psychiatric patients involved their separation from the society through their isolation in closed institutions, thereby setting a stigmatising trend on the sick, and by extension on mental illness, a practice that somehow has remained until now. The profound changes in the field of psychiatry have been important and are reflected in the therapeutic field, as well as in the legislative one, and have contributed to establish changes concerning the social opinion about psychiatric patients...
June 19, 2017: Semergen
https://www.readbyqxmd.com/read/28641925/safety-pharmacokinetics-and-sialic-acid-production-after-oral-administration-of-n-acetylmannosamine-mannac-to-subjects-with-gne-myopathy
#18
Xin Xu, Amy Q Wang, Lea L Latham, Frank Celeste, Carla Ciccone, May Christine Malicdan, Barry Goldspiel, Pramod Terse, James Cradock, Nora Yang, Selwyn Yorke, John C McKew, William A Gahl, Marjan Huizing, Nuria Carrillo
GNE myopathy is a rare, autosomal recessive, inborn error of sialic acid metabolism, caused by mutations in GNE, the gene encoding UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase. The disease manifests as an adult-onset myopathy characterized by progressive skeletal muscle weakness and atrophy. There is no medical therapy available for this debilitating disease. Hyposialylation of muscle glycoproteins likely contributes to the pathophysiology of this disease. N-acetyl-D-mannosamine (ManNAc), an uncharged monosaccharide and the first committed precursor in the sialic acid biosynthetic pathway, is a therapeutic candidate that prevents muscle weakness in the mouse model of GNE myopathy...
April 26, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28641867/motivational-pathways-of-occupational-and-organizational-turnover-intention-among-newly-registered-nurses-in-canada
#19
Claude Fernet, Sarah-Geneviève Trépanier, Mireille Demers, Stéphanie Austin
BACKGROUND: Staff turnover is a major issue for health care systems. In a time of labor shortage, it is critical to understand the motivational factors that underlie turnover intention in newly licensed nurses. PURPOSE: To examine whether different forms of motivation (the reasons for which nurses engage in their work) predict intention to quit the occupation and organization through distinct forms (affective and continuance) and targets (occupation and organization) of commitment...
May 26, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28641704/understanding-the-factors-that-make-public-participation-effective-in-health-policy-and-planning-a-realist-synthesis
#20
Celso P Pagatpatan, Paul R Ward
Although researchers argue for the importance of involving the public in developing health policy, there has been little focus on central research questions - such as what techniques of public participation work, in what circumstances, and why. This paper presents a realist synthesis which identifies and explains the underlying mechanisms and specific contextual factors that lead to effective public participation in health policy and planning. Peer-reviewed, English language literature was searched, which resulted in 77 articles for review and synthesis...
June 23, 2017: Australian Journal of Primary Health
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