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https://www.readbyqxmd.com/read/28549219/design-synthesis-and-properties-of-a-potent-inhibitor-of-pseudomonas-aeruginosa-deacetylase-lpxc
#1
Grazia Piizzi, David T Parker, Yunshan Peng, Markus Rolf Dobler, Anup Patnaik, Som Wattanasin, Eugene Liu, Francois Lenoir, Jill Nunez, John Kerrigan, David McKenney, Colin S Osborne, Donghui Yu, Leanne Lanieri, Jade Bojkovic, JoAnne Dzink-Fox, Maria-Dawn Lilly, Elizabeth R Sprague, Yipin Lu, Hongming Wang, Srijan Ranjitkar, Bing Wang, Meir Glick, Lawrence G Hamann, Ruben Tommasi, Xia Yang, Charles R Dean
Over the past several decades the frequency of antibacterial resistance in hospitals, including multi-drug resistance (MDR) and its association with serious infectious diseases, has increased at alarming rates. Pseudomonas aeruginosa is a leading cause of nosocomial infections, and resistance to virtually all approved antibacterial agents is emerging in this pathogen. To address the need for new agents to treat MDR P. aeruginosa, we focused on inhibiting the first committed step in the biosynthesis of lipid A, the deacetylation of uridyldiphospho-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine by the enzyme LpxC...
May 26, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28548865/a-national-survey-of-canadian-psychiatrists-attitudes-toward-medical-assistance-in-death
#2
Skye Rousseau, Sarah Turner, Harvey Max Chochinov, Murray W Enns, Jitender Sareen
BACKGROUND: Bill C-14 allows for medical assistance in dying (MAID) for patients who have intolerable physical or psychological suffering that occurs in the context of a reasonably foreseeable death. In Canada, psychiatrist support for MAID on the basis of mental illness and beliefs influencing level of support are unknown. The objectives of this research were to 1) determine if psychiatrists are supportive of MAID under certain conditions and on the basis of mental illness and 2) determine what factors are related to psychiatrist support for MAID on the basis of mental illness...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28546981/nurses-commitment-to-respecting-patient-dignity
#3
Zahra Raee, Heidarali Abedi, Mohsen Shahriari
BACKGROUND: Although respecting human dignity is a cornerstone of all nursing practices, industrialization has gradually decreased the attention paid to this subject in nursing care. Therefore, the present study aimed to investigate nurses' commitment to respecting patient dignity in hospitals of Isfahan, Iran. METHODS: This descriptive-analytical study was conducted in hospitals of Isfahan. Overall, 401 inpatients were selected by cluster sampling and then selected simple random sampling from different wards...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28546466/changes-in-brachial-artery-endothelial-function-and-resting-diameter-with-moderate-intensity-continuous-but-not-sprint-interval-training-in-sedentary-men
#4
Ninette Shenouda, Jenna B Gillen, Martin J Gibala, Maureen J MacDonald
Moderate-intensity continuous training (MICT) improves peripheral artery function in healthy adults, a phenomenon that reverses as continued training induces structural remodeling. Sprint interval training (SIT) elicits physiological adaptations similar to MICT despite a lower exercise volume and time-commitment; however, its effect on peripheral artery function and structure is largely unexplored. We compared peripheral artery responses to 12 weeks of MICT and SIT in sedentary, healthy men (age=27±8 years)...
May 25, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28546052/status-report-from-norway-implementation-of-patient-involvement-in-norwegian-health-care
#5
Jürgen Kasper, Anne Regine Lager, Markus Rumpsfeld, Simone Kienlin, Kristine Hoel Smestad, Tone Bråthen, Holly Ankell, Tore Knutsen, Rune Kløvtveit, Pål Gulbrandsen, Per Olav Vandvik, Anja Fog Heen, Signe Flottorp, Geir Tollåli, Øystein Eiring
Norway has traditionally high standards regarding civil rights particularly emphasizing equal access to societal resources including health care. This background and the health care system's centralized national organization make it perfectly suited for implementation of shared decision making (SDM). In recent years, great efforts have been made by policy- makers, regional health authorities and not least the patients to facilitate a process of change in health communication culture. SDM is currently even given highest priority in health care strategies on all system levels...
May 22, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28545945/mindfulness-and-acceptance-based-interventions-for-psychosis-our-current-understanding-and-a-meta-analysis
#6
REVIEW
Stephanie Louise, Molly Fitzpatrick, Clara Strauss, Susan L Rossell, Neil Thomas
In promoting optimal recovery in persons with psychosis, psychological interventions have become a key element of treatment, with cognitive behavioural therapy being widely recommended in clinical practice guidelines. One key area of development has been the trialling of "third wave" cognitive behavioural interventions, which promote mindfulness, acceptance and compassion as means of change. Trials to date have demonstrated encouraging findings, with beneficial effects observed on measures of psychotic symptoms...
May 22, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28545880/stepwise-preconditioning-enhances-mesenchymal-stem-cell-based-cartilage-regeneration-through-epigenetic-modification
#7
Sien Lin, Wayne Yuk Wai Lee, Liangliang Xu, Yujia Wang, Yuanfeng Chen, Kevin Ki Wai Ho, Ling Qin, Xiaohua Jiang, Liao Cui, Gang Li
OBJECTIVE: This study is to investigate the functions and underlying mechanisms of MSCs underwent stepwise preconditioning in chondrogenic medium before expansion, then further explore their therapeutic effects in a surgically induced OA model. METHODS: MSCs isolated from the adult rats expressing Green Fluorescence Protein (GFP) were incubated in basal medium or primed in chondrogenic medium before expansion. The multipotency including cell proliferation, differentiation, and survivability was compared between chondrogenic manipulated MSCs (M-MSCs) and untreated MSCs...
May 22, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28544780/spinal-metastatic-disease-a-review-of-the-role-of-the-multidisciplinary-team
#8
REVIEW
Mark Curtin, Robert P Piggott, Evelyn P Murphy, Sudarshan Munigangaiah, Joseph F Baker, John P McCabe, Aiden Devitt
Historically, a simple approach centered on palliation was applicable to the majority of patients with metastatic spinal disease. With advances in diagnosis and treatment, a more complicated algorithm has devolved requiring a multidisciplinary approach with institutional commitment and support. We performed a database review including pertinent articles exploring the multidisciplinary management of spinal metastatic disease. The wide variation in clinical presentation and tumor response to treatment necessitates a multidisciplinary approach that integrates the diagnosis and treatment of the cancer, symptom management, and rehabilitation for optimal care of patients with spinal metastases...
May 24, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28544766/barriers-and-facilitators-of-mentoring-for-trainees-and-early-career-investigators-in-rheumatology-research-current-state-identification-of-needs-and-roadmap-to-an-inter-institutional-adult-rheumatology-mentoring-program
#9
Alexis Ogdie, Jeffrey A Sparks, Sheila T Angeles-Han, Kathleen Bush, Flavia V Castelino, Amit Golding, Yihui Jiang, J Michelle Kahlenberg, Alfred H J Kim, Yvonne C Lee, Kirthi Machireddy, Michael J Ombrello, Ami A Shah, Zachary S Wallace, Peter A Nigrovic, Una E Makris
OBJECTIVES: Determine perceived barriers and facilitators to effective mentoring for early career rheumatology investigators and develop a framework for an inter-institutional mentoring program. METHODS: Focus groups or interviews with rheumatology fellows, junior faculty, and mentors were conducted, audiotaped and transcribed. Content analysis was performed using NVivo software. Themes were grouped into categories (e.g., mentor-mentee relationship, barriers and facilitators of a productive relationship)...
May 23, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28544409/mind-the-gap-temporal-discrimination-and-dystonia
#10
A Sadnicka, C Daum, C Cordivari, K P Bhatia, J C Rothwell, S Manohar, M J Edwards
BACKGROUND AND PURPOSE: One of the most widely studied perceptual measures of sensory dysfunction in dystonia is the temporal discrimination threshold (TDT) (the shortest interval at which subjects can perceive that there are two stimuli rather than one). However the elevated thresholds described may be due to a number of potential mechanisms as current paradigms test not only temporal discrimination but also extraneous sensory and decision-making parameters. In this study two paradigms designed to better quantify temporal processing are presented and a decision-making model is used to assess the influence of decision strategy...
June 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28544348/galectin-1-promotes-an-m2-macrophage-response-to-polydioxanone-scaffolds
#11
Daniel Abebayehu, Andrew Spence, Barbara D Boyan, Zvi Schwartz, John J Ryan, Michael J McClure
Regulating soft tissue repair to prevent fibrosis and promote regeneration is central to creating a microenvironment conducive to soft tissue development. Macrophages play an important role in this process. Their response can be modulated using biomaterials, altering cytokine and growth factor secretion to promote regeneration. Electrospun polydioxanone (PDO) fiber scaffolds promoted an M2 phenotype when macrophages were cultured on large diameter, highly porous scaffolds, but an M1 phenotype on smaller diameter fibers...
May 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28544331/experiences-and-views-of-married-women-about-domestic-violence
#12
Rukiye Turk, Sevilay Senol Celik, Merve Çetin, Gamze Soydan
AIM: The aim of this study was to determine the experiences and views of married women about the topic of domestic violence. METHODS: This research was planned as a mixed methods study with an in-depth interview and descriptive approach. The study was conducted between November 2011 and December 2012 with 24 married women living in Ankara, Turkey. Two main data-collection tools were used in the study: the "Personal Information Form" and the "In-depth Interview Questionnaire...
May 24, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28544041/marked-variability-observed-in-inpatient-management-of-bronchiolitis-in-three-finnish-hospitals
#13
Varpu Elenius, Eija Bergroth, Petri Koponen, Sami Remes, Pedro A Piedra, Janice A Espinola, Matti Korppi, Carlos A Camargo, Tuomas Jartti
AIM: Infants hospitalised for bronchiolitis undergo examinations and treatments not supported by current research evidence and we investigated practice variations with regard to Finnish children under the age of two. METHODS: This prospective, multi-centre cohort study was conducted in paediatric units in three university hospitals in Finland from 2008-2010. Hospital medical records were reviewed to collect data on clinical course, testing and treatment. Data were analysed separately for children meeting our strict definition of bronchiolitis, aged under 12 months without a history of wheezing, and a loose definition, aged 12-23 months or with a history of wheezing...
May 24, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28544005/hiv-1-p55-gag-protein-induces-senescence-of-human-bone-marrow-mesenchymal-stem-cells-and-reduces-their-capacity-to-support-expansion-of-hematopoietic-stem-cells-in-vitro
#14
Ya-Hong Yuan, Shan-Shan Zhao, Xiao-Li Wang, Zhi-Ping Teng, Dong-Sheng Li, Yi Zeng
Patients with human immunodeficiency virus-1 (HIV-1) infection often present with hematopoietic failure. As the important hematopoietic support cells in the bone marrow (BM), the bone marrow mesenchymal stem cells (BMSCs) can be impacted by HIV proteins that are released by infected cells within BM. In this study, we tested whether HIV protein p55-gag could induce senescence of BMSCs and reduce their capacity to support expansion of hematopoietic stem cells in vitro. BMSCs were chronically treated with p55-gag (BMSCgag ) for up to 20 days, and their proliferative activity and senescence makers were compared to nontreated cells (BMSCcon )...
May 25, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28543756/perventricular-device-closure-of-doubly-committed-sub-arterial-ventricular-septal-defects-via-a-left-infra-axillary-approach
#15
Sijie Zhou, Liyun Zhao, Taibing Fan, Bin Li, Weijie Liang, Haoju Dong, Shubo Song, Lin Liu
BACKGROUND: This study sought to evaluate the feasibility, safety, and efficacy of perventricular device closure of a doubly committed sub-arterial ventricular septal defect (dcVSD) through a left infra-axillary approach. METHOD: Forty-five patients, with a dcVSD of less than 8 mm in diameter, were enrolled in this study. The pericardium was exposed and opened through a left infra-axillary mini-incision. Two parallel purse-string sutures were placed on the right ventricle outflow tract and under transesophageal echocardiography guidance, a delivery sheath loaded with the device was inserted into the right ventricle and advanced through the defect into the left ventricle...
May 24, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28543647/reflections-on-democratic-deliberation-in-bioethics
#16
Amy Gutmann, James W Wagner
Over the course of six years and more than two dozen meetings, members of the Presidential Commission for the Study of Bioethical Issues learned so many things: about emerging science; technological challenges; citizen engagement; the public's, experts', and our own understandings and misperceptions; and even the nature of our own most cherished values. Our commission's commitment to democratic deliberation began deliberatively, when we decided (in the summer of 2010) upon basic principles to guide our first report...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28543411/crowdsourcing-the-moral-limits-of-human-gene-editing
#17
Eric T Juengst
In 2015, a flourish of "alarums and excursions" by the scientific community propelled CRISPR/Cas9 and other new gene-editing techniques into public attention. At issue were two kinds of potential gene-editing experiments in humans: those making inheritable germ-line modifications and those designed to enhance human traits beyond what is necessary for health and healing. The scientific consensus seemed to be that while research to develop safe and effective human gene editing should continue, society's moral uncertainties about these two kinds of experiments needed to be better resolved before clinical trials of either type should be attempted...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28543320/processes-in-acceptance-and-commitment-therapy-and-the-rehabilitation-of-chronic-fatigue
#18
Henrik Børsting Jacobsen, Håvard Kallestad, Nils Inge Landrø, Petter C Borchgrevink, Tore C Stiles
Acceptance and commitment therapy (ACT) has never been tested for patients with chronic fatigue. We aimed to test if a 3.5-week ACT rehabilitation program for patients with chronic fatigue improved quality of life (QoL), fatigue, and psychological flexibility. Further, to test if improvements in QoL and fatigue were associated with improvement in psychological flexibility, and if psychological flexibility explained variance above and beyond maladaptive cognitions typically targeted in CBT for fatigue. Patients (n = 140) who had been on sick leave > 8 weeks due to chronic fatigue received a 3...
June 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/28543218/the-time-course-of-indirect-moral-judgment-in-gossip-processing-modulated-by-different-agents
#19
Xiaozhe Peng, Can Jiao, Fang Cui, Qingfei Chen, Peng Li, Hong Li
Previous studies have investigated personal moral violations with different references (i.e., the protagonists in moral scenarios are the participants themselves or unknown other individuals). However, the roles of various agents in moral judgments have remained unclear. In the present study, ERPs were used to investigate moral judgments when the participants viewed gossip that described (im)moral behaviors committed by different agents (self, friend, celebrity). The results demonstrate that the P2 and late positive component (LPC) correspond to two successive processes of indirect moral judgment when individuals process gossip...
May 24, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28542619/perceptions-of-primary-and-secondary-relationships-in-polyamory
#20
Rhonda N Balzarini, Lorne Campbell, Taylor Kohut, Bjarne M Holmes, Justin J Lehmiller, Jennifer J Harman, Nicole Atkins
In consensually non-monogamous relationships there is an open agreement that one, both, or all individuals involved in a romantic relationship may also have other sexual and/or romantic partners. Research concerning consensual non-monogamy has grown recently but has just begun to determine how relationships amongst partners in consensually non-monogamous arrangements may vary. The current research examines this issue within one type of consensual non-monogamy, specifically polyamory, using a convenience sample of 1,308 self-identified polyamorous individuals who provided responses to various indices of relationship evaluation (e...
2017: PloS One
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