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https://www.readbyqxmd.com/read/28917594/key-steps-in-conducting-systematic-reviews-for-underpinning-clinical-practice-guidelines-methodology-of-the-european-association-of-urology
#1
Thomas Knoll, Muhammad Imran Omar, Steven Maclennan, Virginia Hernández, Steven Canfield, Yuhong Yuan, Max Bruins, Lorenzo Marconi, Hein Van Poppel, James N'Dow, Richard Sylvester
CONTEXT: The findings of systematic reviews (SRs) and meta-analyses (MAs) are used for clinical decision making. The European Association of Urology has committed increasing resources into the development of high quality clinical guidelines based on such SRs and MAs. OBJECTIVE: In this paper, we have summarised the process of conducting SRs for underpinning clinical practice guidelines under the auspices of the European Association of Urology Guidelines Office. EVIDENCE ACQUISITION: The process involves explicit methods and the findings should be reproducible...
September 13, 2017: European Urology
https://www.readbyqxmd.com/read/28916366/measuring-progress-and-projecting-attainment-on-the-basis-of-past-trends-of-the-health-related-sustainable-development-goals-in-188-countries-an-analysis-from-the-global-burden-of-disease-study-2016
#2
(no author information available yet)
BACKGROUND: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 health-related SDG indicators over the period 1990-2016 for 188 countries, and then on the basis of these past trends, we projected indicators to 2030...
September 8, 2017: Lancet
https://www.readbyqxmd.com/read/28915890/barriers-and-enablers-for-the-development-and-implementation-of-allied-health-clinical-practice-guidelines-in-south-african-primary-healthcare-settings-a-qualitative-study
#3
J M Dizon, K Grimmer, Q Louw, S Machingaidze, H Parker, H Pillen
BACKGROUND: The South African allied health (AH) primary healthcare (PHC) workforce is challenged with the complex rehabilitation needs of escalating patient numbers. The application of evidence-based care using clinical practice guidelines (CPGs) is one way to make efficient and effective use of resources. Although CPGs are common for AH in high-income countries, there is limited understanding of how to do this in low- to middle-income countries. This paper describes barriers and enablers for AH CPG uptake in South African PHC...
September 15, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28915813/the-relationship-between-burden-of-childhood-disease-and-foreign-aid-for-child-health
#4
J Clay Bavinger, Paul Wise, Eran Bendavid
BACKGROUND: We sought to examine the relationship between child specific health aid (CHA) and burden of disease. Based on existing evidence, we hypothesized that foreign aid for child health would not be proportional to burden of disease. METHODS: In order to examine CHA and burden of disease, we obtained estimates of these parameters from established sources. Estimates of disability adjusted life years (DALYs) in children (0-5 years) were obtained from the World Health Organization for 2000 and 2012...
September 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28915651/programmed-differentiated-natural-killer-cells-kill-leukemia-cells-by-engaging-slam-family-receptors
#5
Yang Wu, Young Li, Binqing Fu, Linlin Jin, Xiaohu Zheng, Aimei Zhang, Rui Sun, Zhigang Tian, Haiming Wei
Natural killer (NK) cells are important innate immune cells that can directly kill transformed or virus-infected cells. The adoptive transfer of NK cells has been used to treat hematological malignancies; however, the limited sources and quantities of NK cells have restricted their clinical application. Here, we acquired sufficient quantities of functional NK cells from CD34(+) cells treated with a cytokine cocktail. Microarray analysis of the cultured cells revealed a two-stage pattern of programmed differentiation during NK cell development...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915322/hormonal-regulation-of-adipogenesis
#6
Mi-Jeong Lee
Adipose tissue includes multiple anatomical depots that serve as an energy reserve that can expand or contract to maintain metabolic homeostasis. During normal growth and in response to overnutrition, adipose tissue expands by increasing the volume of preexisting adipocytes (hypertrophy) and/or by generating new adipocytes (hyperplasia) via recruitment and differentiation of adipose progenitors. This so-called healthy expansion through hyperplasia is thought to be beneficial in that it protects against obesity associated metabolic disorders by allowing for the "safe" storage of excess energy...
September 12, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28915165/employee-organizational-commitment-and-hospital-performance
#7
Kevin M Baird, Amy Tung, Yanjie Yu
BACKGROUND: There is widespread evidence of the purported benefits of employee organizational commitment (EOC) and its impact on both individual and organizational performance. This study contributes to this literature by providing a unique insight into this relationship, focusing on the interrelationship between EOC with hospital performance and the role of the provision of adequate facilities in eliciting EOC. PURPOSE: The aim of this study was to introduce and empirically examine a new theoretical model in which it is argued that the performance of hospitals with regard to the provision of adequate facilities (medical facilities, support facilities, and staff resources) influences the level of EOC, which in turn influences hospital performance with regard to patient care and operational effectiveness...
September 15, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28914692/increasing-suicide-risk-among-cancer-patients-in-lithuania-from-1993-to-2012-a-cancer-registry-based-study
#8
Auguste Kaceniene, Agne Krilaviciute, Jurgita Kazlauskiene, Giedre Bulotiene, Giedre Smailyte
Certain groups of individuals seem to have an increased risk of committing suicide, and a number of studies have reported an increased risk of suicide among cancer patients. In this study, we aim to estimate the risk of suicide among cancer patients in Lithuania over the period 1993-2012. The records of patients diagnosed with primary cancer were extracted from the population-based Lithuanian Cancer Registry and 273 511 cases of first cancer were included in the analysis. Sex, age and calendar period-standardized mortality ratios (SMRs) were calculated by dividing the observed numbers of suicides among cancer patients by the expected number using national rates...
September 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28914393/costunolide-induces-micronuclei-formation-chromosomal-aberrations-cytostasis-and-mitochondrial-mediated-apoptosis-in-chinese-hamster-ovary-cells
#9
Soma Shiva Nageswara Rao Singireesu, Sunil Misra, Sujan Kumar Mondal, Suresh Yerramsetty, Nivedita Sahu, Suresh Babu K
Costunolide (CE) is a sesquiterpene lactone well-known for its antihepatotoxic, antiulcer, and anticancer activities. The present study focused on the evaluation of the cytogenetic toxicity and cellular death-inducing potential of CE in CHO cells, an epithelial cell line derived from normal ovary cells of Chinese hamster. The cytotoxic effect denoting MTT assay has shown an IC50 value of 7.56 μM CE, where 50% proliferation inhibition occurs. The oxidative stress caused by CE was confirmed based on GSH depletion induced cell death, conspicuously absent in N-acetylcysteine (GSH precursor) pretreated cells...
September 15, 2017: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/28914228/an-integrated-case-management-model-to-assist-pacific-youth-offenders-and-their-families-in-australia
#10
Jioji Ravulo
Pasifika Support Services (PSS) was a program managed by a nongovernment organization, Mission Australia, and funded by the New South Wales Premiers Office to meet the needs of young offenders from a Pacific background. PSS ran from June 2005 to June 2009 and implemented a cost-effective integrated case management model with the New South Wales Police Force adapted to address social risk factors specific to Pacific youth offenders and family support networks. Sixty young people were reviewed regarding the outcomes achieved through their participation, further supported by an evaluation carried out by an external evaluator who found that 65% of participants did not reoffend after 18 months of completing the program...
December 1, 2016: Care Management Journals: Journal of Case Management ; the Journal of Long Term Home Health Care
https://www.readbyqxmd.com/read/28914223/educator-readiness-to-improve-gerontological-curricula-in-health-and-social-service-education
#11
Lynn McCleary, Veronique Boscart, Peter Donahue, Kelsey Harvey
This study investigated the state of gerontology content in health and social service education programs in Ontario, and readiness indicators for change among administrators and faculty. We conducted a survey of teaching faculty (n = 100) and deans or directors (n = 56) of 89 education programs, which revealed mixed evidence on readiness for change. Most respondents thought their programs were adequate but needed enhancement. However, they were unaware of published gerontological competencies with which to evaluate their curricula...
September 15, 2017: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
https://www.readbyqxmd.com/read/28914163/truth-or-punishment-secrecy-and-punishing-the-self
#12
Michael L Slepian, Brock Bastian
We live in a world that values justice; when a crime is committed, just punishment is expected to follow. Keeping one's misdeed secret therefore appears to be a strategic way to avoid (just) consequences. Yet, people may engage in self-punishment to right their own wrongs to balance their personal sense of justice. Thus, those who seek an escape from justice by keeping secrets may in fact end up serving that same justice on themselves (through self-punishment). Six studies demonstrate that thinking about secret (vs...
July 1, 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28913955/controlled-jagged1-delivery-induces-human-embryonic-palate-mesenchymal-cells-to-form-osteoblasts
#13
Jean De La Croix Ndong, Stephenson Yvonne, Michael E Davis, Andrés J García, Steven Goudy
Osteoblast commitment and differentiation are controlled by multiple growth factors including members of the Notch signaling pathway. JAGGED1 is a cell surface ligand of the Notch pathway that is necessary for murine bone formation. The delivery of JAGGED1 to induce bone formation is complicated by its need to be presented in a bound form to allow for proper Notch receptor signaling. In this study we investigate whether the sustained release of JAGGED1 stimulates human mesenchymal cells to commit to osteoblast cell fate using polyethylene glycol malemeide (PEG-MAL) hydrogel delivery system...
September 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28913924/nurse-managers-and-the-sandwich-support-model
#14
Christine Chisengantambu, Guy M Robinson, Nina Evans
AIM: To explore the interplay between the work of nurse managers and the support they receive and provide. BACKGROUND: Support is the cornerstone of management practices and is pivotal in employees feeling committed to an organisation. Support for nurse managers is integral to effective health sector management; its characteristics merit more attention. METHODS: The experiences of 15 nurse managers in rural health institutions in South Australia were explored using structured interviews, observation and document review...
September 15, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28913676/the-cost-of-being-cool-how-adolescent-pseudomature-behavior-maps-onto-adult-adjustment
#15
Leslie Gordon Simons, Tara E Sutton, Sarah Shannon, Mark T Berg, Frederick X Gibbons
During adolescence, one's status among peers is a major concern. Such status is often largely a function of popularity and establishing oneself as "cool." While there are conventional avenues to achieving status among adolescents, engaging in adult-like, or pseudomature, behaviors such as substance use or sexual activity is a frequent occurrence. Although past research has examined the consequences of adolescent delinquency, what remains unclear is the long-term fate of adolescents who are both popular and antisocial...
September 15, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28913417/parasite-biodiversity-faces-extinction-and-redistribution-in-a-changing-climate
#16
Colin J Carlson, Kevin R Burgio, Eric R Dougherty, Anna J Phillips, Veronica M Bueno, Christopher F Clements, Giovanni Castaldo, Tad A Dallas, Carrie A Cizauskas, Graeme S Cumming, Jorge Doña, Nyeema C Harris, Roger Jovani, Sergey Mironov, Oliver C Muellerklein, Heather C Proctor, Wayne M Getz
Climate change is a well-documented driver of both wildlife extinction and disease emergence, but the negative impacts of climate change on parasite diversity are undocumented. We compiled the most comprehensive spatially explicit data set available for parasites, projected range shifts in a changing climate, and estimated extinction rates for eight major parasite clades. On the basis of 53,133 occurrences capturing the geographic ranges of 457 parasite species, conservative model projections suggest that 5 to 10% of these species are committed to extinction by 2070 from climate-driven habitat loss alone...
September 2017: Science Advances
https://www.readbyqxmd.com/read/28912776/human-cd5-innate-lymphoid-cells-are-functionally-immature-and-their-development-from-cd34-progenitor-cells-is-regulated-by-id2
#17
Maho Nagasawa, Kristine Germar, Bianca Blom, Hergen Spits
Innate lymphoid cells (ILCs) have emerged as a key cell type involved in surveillance and maintenance of mucosal tissues. Mouse ILCs rely on the transcriptional regulator Inhibitor of DNA-binding protein 2 (Id2) for their development. Here, we show that Id2 also drives development of human ILC because forced expression of Id2 in human thymic progenitors blocked T cell commitment, upregulated CD161 and promyelocytic leukemia zinc finger (PLZF), and maintained CD127 expression, markers that are characteristic for human ILCs...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28912539/diphenyleneiodonium-chloride-dpic-displays-broad-spectrum-bactericidal-activity
#18
Manitosh Pandey, Alok Kumar Singh, Ritesh Thakare, Sakshi Talwar, Pratiksha Karaulia, Arunava Dasgupta, Sidharth Chopra, Amit Kumar Pandey
Indiscriminate use of antibiotics globally has lead to an increase in emergence of drug-resistant pathogens under both nosocomial, as well as more worryingly, in community setting as well. Further, a decrease in the corporate interest and financial commitment has exerted increasing pressure on a rapidly dwindling antimicrobial drug discovery and developmental program. In this context, we have screened the Library of Pharmacologically Active Compounds (LOPAC, Sigma) against Staphylococcus aureus and Mycobacterium tuberculosis to identify potent novel antimicrobial molecules amongst non-antibiotic molecules...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912455/a-crispr-screen-identifies-genes-controlling-etv2-threshold-expression-in-murine-hemangiogenic-fate-commitment
#19
Haiyong Zhao, Kyunghee Choi
The ETS transcription factor Etv2 is necessary and sufficient for the generation of hematopoietic and endothelial cells. However, upstream regulators of Etv2 in hemangiogenesis, generation of hematopoietic and endothelial cells, have not been clearly addressed. Here we track the developmental route of hemangiogenic progenitors from mouse embryonic stem cells, perform genome-wide CRISPR screening, and transcriptome analysis of en route cell populations by utilizing Brachyury, Etv2, or Scl reporter embryonic stem cell lines to further understand the mechanisms that control hemangiogenesis...
September 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28905979/-cyanosis-in-a-calf-with-a-double-outlet-right-ventricle
#20
Nicola Wiedemann, Nicolai Hildebrandt, Manfred Henrich, Estelle Henrich, Matthias Schneider
A 4-day-old female Holstein Friesian calf was presented for evaluation of cyanosis and dyspnea. On auscultation, severe bronchovesicular sounds and a systolic heart murmur of grade IV/VI above the tricuspid valve were found. On echocardiography, a marked dextroposition of the aorta (> 50% originating from the right ventricle), leading to both great arteries arising from the right ventricle - a so-called double-outlet right ventricle - was detected. Two ventricular septal defects were present, one in the perimembranous, subpulmonary region, the other non-committed in the muscular region...
September 13, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
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