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https://www.readbyqxmd.com/read/29787036/reflections-of-a-black-african-insider-researcher
#1
Isaac Tuffour
BACKGROUND: There is a growing body of literature providing reflective accounts and critical examination of the challenges faced by insider researchers. However, there is little research about the specific challenges that black African insider nurse researchers face. AIM: To reflect on the complexities black African insider nurse researchers face in the context of research sites, participants and the interpretation of data. DISCUSSION: Insider researchers are susceptible to various entanglements and dilemmas...
May 22, 2018: Nurse Researcher
https://www.readbyqxmd.com/read/29785247/being-enjoyably-challenged-is-the-key-to-an-enjoyable-gaming-experience-an-experimental-approach-in-a-first-person-shooter-game
#2
Anne Corcos
Applied to video games, Csikszentmihalyi's work on flow evidences that a positive gaming experience is intrinsically self-rewarding and primarily determined by the skill/challenge balance. A multi-layered measure of enjoyment is built to take these components into account. Gamers were asked to report the concentration-enjoyment they experienced during a first-person shooter game, and to better assess the gap between skill and challenge, the challenge enjoyment was also rated. Along with concentration level, concentration enjoyment is used to build a gaming experience typology that accounts for the self-rewarding component...
2018: Socioaffective Neuroscience & Psychology
https://www.readbyqxmd.com/read/29784917/clonal-analysis-of-notch1-expressing-cells-reveals-the-existence-of-unipotent-stem-cells-that-retain-long-term-plasticity-in-the-embryonic-mammary-gland
#3
Anna M Lilja, Veronica Rodilla, Mathilde Huyghe, Edouard Hannezo, Camille Landragin, Olivier Renaud, Olivier Leroy, Steffen Rulands, Benjamin D Simons, Silvia Fre
Recent lineage tracing studies have revealed that mammary gland homeostasis relies on unipotent stem cells. However, whether and when lineage restriction occurs during embryonic mammary development, and which signals orchestrate cell fate specification, remain unknown. Using a combination of in vivo clonal analysis with whole mount immunofluorescence and mathematical modelling of clonal dynamics, we found that embryonic multipotent mammary cells become lineage-restricted surprisingly early in development, with evidence for unipotency as early as E12...
May 21, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29784646/latest-developments-in-muc1-immunotherapy
#4
REVIEW
Joyce Taylor-Papadimitriou, Joy M Burchell, Rosalind Graham, Richard Beatson
Currently, there is renewed interest in attempting to recruit the host immune system to eliminate cancers, and within this renewed activity, MUC1 continues to arouse interest. MUC1 has been considered a possible therapeutic target for the past 30 years as it is up-regulated, aberrantly glycosylated and its polarization is lost in many adenocarcinomas. Moreover, MUC1 is expressed by some haematopoietic cancers, including acute myeloid leukaemia and myeloma. Although multiple clinical trials have been initiated and immune responses have been documented, effective clinical benefit worthy of approval for general application has not as yet been achieved...
May 21, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29784229/burnout-evaluation-and-potential-predictors-in-a-greek-cohort-of-mental-health-nurses
#5
Adamos-Konstantinos Konstantinou, Konstantinos Bonotis, Maria Sokratous, Vasileios Siokas, Efthimios Dardiotis
BACKGROUND: Job burnout is one of the most serious occupational health hazards, especially, among mental health nurses. It has been attributed among others to staff shortages, health service changes, poor morale and insufficient employee participation in decision-making. AIM: The aim of this study was to measure burnout among mental health nurses, investigate relations between burnout and organizational factors and examine potential predictors of nurses' burnout...
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29784213/knowledge-and-perceptions-of-undergraduate-nurses-towards-the-use-of-cocaine-smoked-in-a-brazilian-context
#6
Sérgia Cristina Cavalcante Pereira, Luciana Marques Andreto, Ariani Impieri Souza, Iracema da Silva Frazão, Goolan Hussein Rassool, Sandra Cristina Pillon
The aim of the study was to evaluate the perceptions and knowledge of nursing students on the identification and intervention care among users of cocaine (smoked) patients. A cross-sectional survey design was conducted with 164 undergraduate nursing students of two nursing school from Northeast of Brazil. A questionnaire on knowledge and attitudes and therapeutic commitment towards the use of cocaine (smoked) were used. The students stated that they received contents of substance misuse in the curriculum of nursing...
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29783872/global-mental-health-and-the-national-institute-of-mental-health-research-domain-criteria
#7
Stevan Merill Weine, Scott Langenecker, Aliriza Arenliu
BACKGROUND: The National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) project presents innovative ways of investigating mental illness based on behavioral and neurobiological measures of dimensional processes. Although cultural psychiatrists have critiqued RDoC's implications and limitations for its under-developed focus on context and experience, RDoC presents opportunities for synergies with global mental health. It can capture aspects of clinical or sub-clinical behavior which are less dependent upon Diagnostic and Statistical Manual of Mental Disorders (5th ed...
May 1, 2018: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/29783179/staged-crime-scene-determination-by-handling-physical-and-digital-evidence-reports-and-review-of-the-literature
#8
REVIEW
Francesco Lupariello, Serena Curti, Janet Barber Duval, Giovanni Abbattista, Giancarlo Di Vella
Geberth in 2006 stated that "staging is a conscious criminal action on the part of an offender to thwart an investigation." In the present paper two crime scenes staged by handling digital evidence are reported. The first case involves a 50-year-old woman who had been living with the offender for three years before he murdered her at the end of their relationship. He staged the scene as a sex-related crime committed by an unknown perpetrator. The second case concerns a young woman who was found dead in Southern Italy in January 2004 with a gunshot on the forehead...
May 16, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29782940/defining-osteoblast-and-adipocyte-lineages-in-the-bone-marrow
#9
J L Pierce, D L Begun, J J Westendorf, M E McGee-Lawrence
Bone is a complex endocrine organ that facilitates structural support, protection to vital organs, sites for hematopoiesis, and calcium homeostasis. The bone marrow microenvironment is a heterogeneous niche consisting of multipotent musculoskeletal and hematopoietic progenitors and their derivative terminal cell types. Amongst these progenitors, bone marrow mesenchymal stem/stromal cells (BMSCs) may differentiate into osteogenic, adipogenic, myogenic, and chondrogenic lineages to support musculoskeletal development as well as tissue homeostasis, regeneration and repair during adulthood...
May 18, 2018: Bone
https://www.readbyqxmd.com/read/29782368/tiny-moments-matter-promoting-professionalism-in-everyday-practice
#10
Elizabeth C Bernabeo, Benjamin Chesluk, Lorna Lynn
INTRODUCTION: Professionalism rests upon a number of individual, environmental, and societal level factors, leading to specific professional behavior in specific situations. Focusing on professional lapses to identify and remediate unprofessional physicians is incomplete. We explored professionalism in practicing internal medicine physicians in the context of everyday practice, to highlight how typical experiences contribute to positive, yet often unnoticed, professional behavior. METHODS: In-depth interviews were used to uncover 13 physicians' most meaningful experiences of professionalism...
May 16, 2018: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/29782074/supporting-women-at-the-time-of-abortion-a-mixed-methods-study-of-male-partner-experiences-and-perspectives
#11
Brian T Nguyen, Luciana E Hebert, Sara L Newton, Melissa L Gilliam
CONTEXT: Although men are commonly viewed as unaware, uninvolved and even obstructive regarding their partner's abortion access, those who accompany women to an abortion appointment may be more supportive. A better understanding of men's motivations could inform clinic policies regarding their involvement. METHODS: In 2015-2016, data were collected from male partners of women seeking an abortion at two clinics in a large Midwestern city. Twenty-nine interviews were conducted to explore how men wanted to be involved in the abortion and why they accompanied their partners...
May 21, 2018: Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/29781215/strap-deficiency-impairs-mouse-embryonic-stem-cells-lineage-commitment-through-cyp26a1-mediated-retinoic-acid-homeostasis
#12
Lin Jin, Chenbei Chang, Kevin M Pawlik, Arunima Datta, Larry M Johnson, Trung Vu, Joseph L Napoli, Pran K Datta
Retinoic acid (RA) signaling is essential for the differentiation of embryonic stem cells (ESCs) and vertebrate development. RA biosynthesis and metabolism are controlled by a series of enzymes, but the molecular regulators of these enzymes remain largely obscure. In this study, we investigated the functional role of the WD-domain protein STRAP (serine threonine kinase receptor-associated protein) in the pluripotency and lineage commitment of murine ESCs. We generated Strap knockout (KO) mouse ESCs and subjected them to spontaneous differentiation...
May 21, 2018: Stem Cells
https://www.readbyqxmd.com/read/29781179/pigmentation-is-associated-with-stemness-hierarchy-of-progenitor-cells-within-cultured-limbal-epithelial-cells
#13
Lei Liu, Frederik Mølgaard Nielsen, Jeppe Emmersen, Chris Bath, Jesper Østergaard Hjortdal, Simone Riis, Trine Fink, Cristian Pablo Pennisi, Vladimir Zachar
Ex-vivo cultured human limbal epithelial stem/progenitor cells (hLESCs) are the main source for regenerative therapy of limbal stem cell deficiency (LSCD), which is worldwide one of the major causes of corneal blindness. Despite many stemness-associated markers have been identified within the limbal niche, the phenotype of the earliest hLESCs has not been hitherto identified. We sought to confirm or refute the use of tumor protein p63 (p63) and ATP binding cassette subfamily B member 5 (ABCB5) as surrogate markers for hLESCs early within the limbal differentiation hierarchy...
May 20, 2018: Stem Cells
https://www.readbyqxmd.com/read/29781119/the-effect-of-lifelong-exercise-frequency-on-arterial-stiffness
#14
Shigeki Shibata, Naoki Fujimoto, Jeffrey L Hastings, Graeme Carrick-Ranson, Paul S Bhella, Christopher Hearon, Benjamin D Levine
Central arterial stiffness increases with sedentary aging. While near-daily, vigorous lifelong (>25 yr) endurance exercise training prevents arterial stiffening with aging, this rigorous routine of exercise training over a lifetime is impractical for most individuals. The aim was to examine whether a less frequent 'dose' of lifelong exercise training (4-5 sessions/wk for > 30 min) that is consistent with current physical activity recommendations elicits similar benefits on central arterial stiffening with aging...
May 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29779898/oncostatin-m-and-kit-ligand-control-hematopoietic-stem-cell-fate-during-zebrafish-embryogenesis
#15
Christopher B Mahony, Corentin Pasche, Julien Y Bertrand
Understanding the molecular pathways controlling hematopoietic stem cell specification and expansion is a necessary milestone to perform regenerative medicine. Here, we used the zebrafish model to study the role of the ckit signaling pathway in this process. We show the importance of kitb/kitlgb signaling in the specification and expansion of hematopoietic stem cells (HSCs), in the hemogenic endothelium and caudal hematopoietic tissue (CHT), respectively. Moreover, we identified the zebrafish ortholog of Oncostatin M (osm) in the zebrafish genome...
May 10, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29779826/the-bckdh-kinase-and-phosphatase-integrate-bcaa-and-lipid-metabolism-via-regulation-of-atp-citrate-lyase
#16
Phillip J White, Robert W McGarrah, Paul A Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan M Haldeman, Thomas Grenier-Larouche, Jie An, Amanda L Lapworth, Inna Astapova, Sarah A Hannou, Tabitha George, Michelle Arlotto, Lyra B Olson, Michelle Lai, Guo-Fang Zhang, Olga Ilkayeva, Mark A Herman, R Max Wynn, David T Chuang, Christopher B Newgard
Branched-chain amino acids (BCAA) are strongly associated with dysregulated glucose and lipid metabolism, but the underlying mechanisms are poorly understood. We report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that regulates branched-chain ketoacid dehydrogenase (BCKDH), the committed step of BCAA catabolism, lowers circulating BCAA, reduces hepatic steatosis, and improves glucose tolerance in the absence of weight loss in Zucker fatty rats. Phosphoproteomics analysis identified ATP-citrate lyase (ACL) as an alternate substrate of BDK and PPM1K...
May 11, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29778258/new-treatments-have-changed-the-game-hepatitis-c-treatment-in-primary-care
#17
REVIEW
Shelley N Facente, Katie Burk, Kelly Eagen, Elise S Mara, Aaron A Smith, Colleen S Lynch
In the pre-direct-acting antiviral era, hepatitis C virus (HCV) treatments were complex and largely managed by hepatologists, gastroenterologists, and infectious disease physicians. As direct-acting antivirals have driven up demand for treatment, the relative scarcity of these specialists has created a bottleneck effect, resulting in only a fraction of HCV-infected individuals offered treatment. The San Francisco Health Network is a safety net system of care. Its intervention was designed to be sustainable and scalable; with minimal time commitments for training providers, primary care-based HCV treatment increased 3-fold in a period of just over 3 years...
June 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29778257/localized-us-efforts-to-eliminate-hepatitis-c
#18
REVIEW
Annette Gaudino, Bryn Gay, Clifton Garmon, Mike Selick, Reed Vreeland, Katie Burk, Emalie Huriaux, Shelley N Facente, Annie Luetkemeyer, Phil Waters, Camilla S Graham
The United States has national plans for the elimination of hepatitis C virus but much of US health care is organized on the state level and requires local solutions. This article describes the plans developed by New York, Massachusetts, and the city/county of San Francisco for hepatitis C virus elimination. Coalitions capitalize on existing resources and advocate for new resources to address barriers in hepatitis C virus care. Although each coalition has distinct plans, all share a commitment to groups that are disproportionately affected and are at risk for being excluded from advances in hepatitis C virus treatment and cure...
June 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29777950/acceptance-and-commitment-therapy-for-prevention-of-chronic-post-surgical-pain-and-opioid-use-in-at-risk-veterans-a-pilot-randomized-controlled-study
#19
Lilian Dindo, M Bridget Zimmerman, Katherine Hadlandsmyth, Barbara StMarie, Jennie Embree, James Marchman, Toni Tripp-Reimer, Barbara Rakel
High levels of pain, significant anxiety, and/or depressive symptoms prior to surgery put patients at elevated risk forchronic pain and prolonged opioid use following surgery. The purpose of this preliminary study was to assess the efficacy of a one-day Acceptance and Commitment Therapy (ACT) workshop in "at-risk" Veterans for the prevention of chronic pain and opioid use following orthopedic surgery. In a randomized controlled trial, 88 at-risk Veterans undergoing orthopedic surgery were assigned to Treatment as Usual (TAU; N =44) or TAU plus a 1-day ACT workshop (N = 44)...
May 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29777832/novel-cysteine-and-albumin-adduct-biomarkers-to-prove-human-poisoning-with-the-pesticide-oxydemeton-s-methyl
#20
Harald John, Markus Siegert, Florian Eyer, Franz Worek, Horst Thiermann, Andreas Kranawetvogl
We herein report on the forensic analysis of plasma samples to prove human poisoning with oxydemeton-S-methyl (ODM), S-(2-(ethylsulfinyl)ethyl)-O,O-dimethyl phosphorothioate. This organophosphorus pesticide is the active ingredient of Metasystox® , that was swallowed by a 77-year-old woman to commit suicide. ODM belongs to the class of dimethyl phosphoryl (DMP) pesticides, contains a 2-(ethylsulfinyl)ethanethiol (ESOET) leaving group and undergoes adduct formation with endogenous molecules as elaborated herein with human serum exposed to pesticides in vitro...
May 16, 2018: Toxicology Letters
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