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Maleic acid

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https://www.readbyqxmd.com/read/28934548/controlling-styrene-maleic-acid-lipid-particles-through-raft
#1
Anton A A Smith, Henriette Elisabeth Autzen, Tomas Laursen, Vincent Wu, Max Yen, Aaron Hall, Scott D Hansen, Yifan Cheng, Ting Xu
The ability of styrene maleic acid copolymers to dissolve lipid membranes into nanosized lipid particles is a facile method of obtaining membrane proteins in solubilized lipid discs while conserving part of its native lipid environment. While the currently used copolymers can readily extract membrane proteins in native nanodiscs, their highly disperse composition is likely to influence the dispersity of the discs as well as the extraction efficiency. In this study, reversible addition fragmentation chain transfer was used to control the polymer architecture and dispersity of molecular weights with a high-precision...
September 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28930432/injectable-stem-cell-laden-open-porous-microgels-that-favour-adipogenesis-in-vitro-and-in-vivo-evaluation
#2
Pengfei Xia, Kunxi Zhang, Yan Gong, Guifei Li, Shifeng Yan, Jingbo Yin
Microgels, with large surface area per volume, show great advantages in adipose tissue engineering due to their injectability and similarity with natural extracellular matrix. However, to date, no studies have tried applying microgels to adipose tissue regeneration. Herein, based on double bonded poly-(L-glutamic acid)-g-2-Hydroxyethyl methacrylate (PLGA-g-HEMA) and maleic anhydride-modified chitosan (MCS), an open porous microgel with high hydrophilicity and great injectability is successfully prepared (microgels diameter of 200-300 μm, pore diameter of 38 μm, and porosity of 88...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28923687/thermotropic-properties-of-phosphatidylcholine-nanodiscs-bounded-by-styrene-maleic-acid-copolymers
#3
J J Dominguez Pardo, J M Dörr, M F Renne, T Ould-Braham, M C Koorengevel, M J van Steenbergen, J A Killian
Styrene-maleic acid copolymers (SMA) have been gaining interest in the field of membrane research due to their ability to solubilize membranes into nanodics. The SMA molecules act as an amphipathic belt that surrounds the nanodiscs, whereby the hydrophobic styrene moieties can insert in between the lipid acyl chains. Here we used SMA variants with different styrene-to-maleic acid ratio (i.e. 2:1, 3:1 and 4:1) to investigate how lipid packing in the nanodiscs is affected by the presence of the polymers and how it depends on polymer composition...
September 15, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28920693/ph-tunable-and-divalent-metal-ion-tolerant-polymer-lipid-nanodiscs
#4
Thirupathi Ravula, Nathaniel Hardin, Sudheer Ramadugu, Ayyalusamy Ramamoorthy
The development and applications of detergent-free membrane mimetics have been the focus for the high-resolution structural and functional studies on membrane proteins. The introduction of lipid nanodiscs has attracted new attention towards the structural biology of membrane proteins and also enabled biomedical applications. Lipid nanodiscs provide a native lipid bilayer environment similar to the cell membrane surrounded by a belt made up of proteins or peptides. Recent studies have shown that the hydrolyzed form of styrene maleic anhydride copolymer (SMA) has the ability to form lipid nanodiscs and has several advantages over protein or peptide based nanodiscs...
September 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28915534/revealing-anti-inflammation-mechanism-of-water-extract-and-oil-of-forsythiae-fructus-on-carrageenan-induced-edema-rats-by-serum-metabolomics
#5
An Yuan, Lihong Gong, Lin Luo, Jue Dang, Xiaohong Gong, Mengjie Zhao, Yan Li, Yunxia Li, Cheng Peng
Forsythiae Fructus is an important Chinese medicine which shows a significant effect against inflammation. This study aimed to investigate the preventive anti-inflammation mechanism of Forsythiae Fructus by serum metabolomics strategy and compare the difference of the metabolism pathways between Forsythia extract and Forsythia oil in rat. Four groups (control group, model group, Forsythia extract group and Forsythia oil group) were orally administered 10mL/kg 0.5% Tween 80 solution, 10mL/kg 0.5% Tween 80 solution, 5g/kg Forsythia extract and 0...
September 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28912575/thermodynamics-of-nanodisc-formation-mediated-by-styrene-maleic-acid-2-1-copolymer
#6
Anne Grethen, Abraham Olusegun Oluwole, Bartholomäus Danielczak, Carolyn Vargas, Sandro Keller
Styrene/maleic acid copolymers (SMA) have recently attracted great interest for in vitro studies of membrane proteins, as they self-insert into and fragment biological membranes to form polymer-bounded nanodiscs that provide a native-like lipid-bilayer environment. SMA copolymers are available in different styrene/maleic acid ratios and chain lengths and, thus, possess different charge densities, hydrophobicities, and solubilisation properties. Here, we studied the equilibrium solubilisation properties of the most commonly used copolymer, SMA(2:1), by monitoring the formation of nanodiscs from phospholipid vesicles using (31)P nuclear magnetic resonance spectroscopy, dynamic light scattering, and differential scanning calorimetry...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892400/poly-vinyl-methyl-ether-maleic-anhydride-doped-peg-pla-nanoparticles-for-oral-paclitaxel-delivery-to-improve-bioadhesive-efficiency
#7
Qian Wang, Chan Li, Tianyang Ren, Shizhu Chen, Xiaoxia Ye, Hongbo Guo, Haibing He, Yu Zhang, Tian Yin, Xing-Jie Liang, Xing Tang
Bioadhesive nanoparticles based on poly(vinyl methyl ether/maleic anhydride) (PVMMA) and poly(ethylene glycol) methyl ether-b-poly(d,l-lactic acid) (mPEG-b-PLA) were produced by the emulsification solvent evaporation method. Paclitaxel was utilized as the model drug, with an encapsulation efficiency of up to 90.2 ± 4.0%. The nanoparticles were uniform and spherical in shape and exhibited a sustained drug release compared with Taxol. m-NPs also exhibited favorable bioadhesive efficiency at the same time. Coumarin 6 or DiR-loaded nanoparticles with/without PVMMA (C6-m-NPs/DiR-m-NPs or C6-p-NPs/DiR-p-NPs) were used for cellular uptake and intestinal adhesion experiments, respectively...
September 20, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28890256/tuneable-denture-adhesives-using-biomimetic-principles-for-enhanced-tissue-adhesion-in-moist-environments
#8
Simrone K Gill, Nima Roohpour, Paul D Topham, Brian J Tighe
Nature provides many interesting examples of adhesive strategies. Of particular note, the protein glue secreted by marine mussels delivers high adhesion in wet and dynamic environments owing to existence of catechol moieties. As such, this study focuses on denture fixatives, where a non-zinc-containing commercial-based formulation has been judiciously modified by a biomimetic catechol-inspired polymer, poly(3,4-dihydroxystyrene/styrene-alt-maleic acid) in a quest to modulate adhesive performance. In vitro studies, in a lap-shear configuration, revealed that the catechol-modified components were able to enhance adhesion to both the denture base and hydrated, functional oral tissue mimic, with the resulting mode of failure prominently being adhesive rather than cohesive...
September 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28887799/study-of-polar-organic-compounds-in-airborne-particulate-matter-of-a-coastal-urban-city
#9
Dimitra Balla, Dimitra Voutsa, Constantini Samara
Two classes of polar organic compounds, dicarboxylic acids (DCAs) and sugars/sugar anhydrides (S/SAs), were measured in airborne particulate matter in the area of Thessaloniki, northern Greece. The target compounds were measured simultaneously in two particle fractions PM10 and PM2.5 during cold and warm periods by employing extraction in an ultrasonic bath with a mixture of MeOH/DCM (1:2 v/v), derivatization with BSTFA-TMCS and GC-MS for analysis. At both fractions, phthalic was the predominant carboxylic acid during cold season and a-ketoglutaric acid in warm season, followed by maleic and malic...
September 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28881139/fracture-targeted-delivery-of-%C3%AE-catenin-agonists-via-peptide-functionalized-nanoparticles-augments-fracture-healing
#10
Yuchen Wang, Maureen R Newman, Marian Ackun-Farmmer, Michael P Baranello, Tzong-Jen Sheu, J Edward Puzas, Danielle S W Benoit
Despite several decades of progress, bone specific drug delivery is still a major challenge. Current bone-acting drugs require high-dose systemic administration which decreases therapeutic efficacy and increases off-target tissue effects. Here, a bone-targeted nanoparticle (NP) delivery system for a β-catenin agonist, 3-amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide, a glycogen synthase kinase 3 beta (GSK-3β) inhibitor, was developed to enhance fracture healing...
September 7, 2017: ACS Nano
https://www.readbyqxmd.com/read/28867660/effects-of-smear-layer-removal-agents-on-the-physical-properties-and-microstructure-of-mineral-trioxide-aggregate-cement
#11
Nidambur Vasudev Ballal, Mrunali Sona, Franklin R Tay
OBJECTIVE: To compare the effect of QMix (Dentsply Sirona), 7% maleic acid (MA), and 17% ethylenediaminetetraacetic acid (EDTA) on the microhardness, flexural strength and microstructure of mineral trioxide aggregate (MTA; ProRoot MTA, Dentsply Sirona). METHODS: Forty MTA specimens were divided into four groups: [I] QMix [II] 7% MA [III] 17% EDTA and [IV] distilled water (control). After treatment with 5mL of the respective solution for 1min, the specimens were tested for microhardness using a Knoop hardness tester...
September 1, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28865797/structure-and-function-of-membrane-proteins-encapsulated-in-a-polymer-bound-lipid-bilayer
#12
REVIEW
Naomi L Pollock, Sarah C Lee, Jaimin H Patel, Aiman A Gulamhussein, Alice J Rothnie
New technologies for the purification of stable membrane proteins have emerged in recent years, in particular methods that allow the preparation of membrane proteins with their native lipid environment. Here, we look at the progress achieved with the use of styrene-maleic acid copolymers (SMA) which are able to insert into biological membranes forming nanoparticles containing membrane proteins and lipids. This technology can be applied to membrane proteins from any host source, and, uniquely, allows purification without the protein ever being removed from a lipid bilayer...
August 30, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28860530/low-molecular-weight-organic-acids-correlate-with-cultivar-variation-in-ciprofloxacin-accumulation-in-brassica-parachinensis-l
#13
Hai-Ming Zhao, Lei Xiang, Xiao-Lian Wu, Yuan-Neng Jiang, Hui Li, Yan-Wen Li, Quan-Ying Cai, Ce-Hui Mo, Jie-Sheng Liu, Ming-Hung Wong
To understand the mechanism controlling cultivar differences in the accumulation of ciprofloxacin (CIP) in Chinese flowering cabbage (Brassica parachinensis L.), low-molecular-weight organic acids (LMWOAs) secreted from the roots of high- and low-CIP cultivars (Sijiu and Cutai, respectively) and their effects on the bioavailability of CIP in soil were investigated. Significant differences in the content of LMWOAs (especially maleic acid) between the two cultivars played a key role in the variation in CIP accumulation...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28846986/chemical-characteristics-of-dicarboxylic-acids-and-related-organic-compounds-in-pm2-5-during-biomass-burning-and-non-biomass-burning-seasons-at-a-rural-site-of-northeast-china
#14
Fang Cao, Shi-Chun Zhang, Kimitaka Kawamura, Xiaoyan Liu, Chi Yang, Zufei Xu, Meiyi Fan, Wenqi Zhang, Mengying Bao, Yunhua Chang, Wenhuai Song, Shoudong Liu, Xuhui Lee, Jun Li, Gan Zhang, Yan-Lin Zhang
Fine particulate matter (PM2.5) samples were collected using a high-volume air sampler and pre-combusted quartz filters during May 2013 to January 2014 at a background rural site (47(∘)35 N, 133(∘)31 E) in Sanjiang Plain, Northeast China. A homologous series of dicarboxylic acids (C2-C11) and related compounds (oxoacids, α-dicarbonyls and fatty acids) were analyzed by using a gas chromatography (GC) and GC-MS method employing a dibutyl ester derivatization technique. Intensively open biomass-burning (BB) episodes during the harvest season in fall were characterized by high mass concentrations of PM2...
August 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28831798/cross-linked-polyelectrolyte-for-improved-selectivity-and-processability-of-iontronic-systems
#15
Theresia Arbring Sjöström, Amanda Jonsson, Erik Gabrielsson, Loïg Kergoat, Klas Tybrandt, Magnus Berggren, Daniel T Simon
On-demand local release of biomolecules enables fine-tuned stimulation for the next generation of neuromodulation therapies. Such chemical stimulation is achievable using iontronic devices based on microfabricated, highly selective ion exchange membranes (IEMs). Current limitations in processability and performance of thin film IEMs hamper future developments of this technology. Here we address this limitation by developing a cationic IEM with excellent processability and ionic selectivity: poly(4-styrenesulfonic acid-co-maleic acid) (PSS-co-MA) cross-linked with polyethylene glycol (PEG)...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28821149/solution-blow-spun-nanocomposites-of-poly-lactic-acid-cellulose-nanocrystals-from-eucalyptus-kraft-pulp
#16
Delne Domingos da Silva Parize, Juliano Elvis de Oliveira, Tina Williams, Delilah Wood, Roberto de Jesús Avena-Bustillos, Artur Piotr Klamczynski, Gregory Melvin Glenn, José Manoel Marconcini, Luiz Henrique Capparelli Mattoso
Cellulose nanocrystals (CNCs) were extracted from Eucalyptus kraft pulp by sulfuric acid hydrolysis, and esterified with maleic anhydride (CNCMA). The incorporation of sulfate ester groups on the cellulose surface resulted in higher stability of the nanoparticles in aqueous suspensions and lower thermal stability. Then, PLA/CNC and PLA/CNCMA nanocomposites were successfully obtained by solution blow spinning (SBS) using dimethyl carbonate (DMC) as solvent. CNC and CNCMA indicated to be acting both as nucleating agents or growth inhibitors of PLA crystal and tends to favor the formation of PLA crystals of higher stability...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28808097/photoprotection-through-ultrafast-charge-recombination-in-photochemical-reaction-centres-under-oxidizing-conditions
#17
Fei Ma, David J K Swainsbury, Michael R Jones, Rienk van Grondelle
Engineering natural photosynthesis to address predicted shortfalls in food and energy supply requires a detailed understanding of its molecular basis and the intrinsic photoprotective mechanisms that operate under fluctuating environmental conditions. Long-lived triplet or singlet excited electronic states have the potential to cause photodamage, particularly in the presence of oxygen, and so a variety of mechanisms exist to prevent formation of such states or safely dissipate their energy. Here, we report a dramatic difference in spectral evolution in fully reduced and partially oxidized Rhodobacter sphaeroides reaction centres (RCs) following excitation of the monomeric bacteriochlorophyll (BChl) cofactors at 805 nm...
September 26, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28806680/sequestration-of-aluminium-iii-by-different-natural-and-synthetic-organic-and-inorganic-ligands-in-aqueous-solution
#18
Paola Cardiano, Rosalia Maria Cigala, Francesco Crea, Fausta Giacobello, Ottavia Giuffrè, Anna Irto, Gabriele Lando, Silvio Sammartano
The speciation of Al(3+) in aqueous solutions containing organic and inorganic ligands important from a biological (citrate (Cit(3-)), gluconate (Gluc(-)), lactate (Lac(-)), silicate (H2SiO4(2-)), carbonate (CO3(2-)), fluoride (F(-))) and industrial (Gantrez(®); polymethyl-vinyl-ether-co-maleic acids; GTZ S95 and GTZ AN169) point of view is reported. The stability constants of Al(3+)/L(z-) complexes (L(z-) = ligand with z(-) charge) were determined by potentiometry at T = 298.15 K and 0.10 ≤ I/M ≤ 1...
November 2017: Chemosphere
https://www.readbyqxmd.com/read/28804810/assessing-the-phytoavailability-of-arsenic-and-phosphorus-to-corn-plant-after-the-addition-of-an-acrylic-copolymer-to-polluted-soils
#19
Tahereh Mansouri, Ahmad Golchin, Hossein Kouhestani
Soil pollution by arsenic increases the potential risk of arsenic entrance into the food chain. The usefulness of maleic anhydride- styrene- acrylic acid copolymer on the mobility and phytoavailability of arsenic was evaluated. Treatments were the concentrations of acrylic copolymer (0, 0.05, 0.10, and 0.20% w/w) and the concentrations of soil total arsenic (0, 6, 12, 24, 48, and 96 mg kg(-1)). Sodium arsenate was added in appropriate amounts to subsamples of an uncontaminated soil to give contaminated soils with different levels of arsenic...
August 13, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28782855/effect-of-maleic-acid-on-the-bond-strength-of-fibre-posts-to-root-dentine
#20
Fan Fan, Muhammad Ibrahim, Panpan Dai, Yixin Mao, Bing He, Gang Wu, Jianfeng Ma, Shengbin Huang
The aim of this study was to evaluate the effect of maleic acid (MA) on both the bond strength of fibre post to root dentine and smear layer removal after post space preparation. Sixty, single-canal premolars were endodontically treated and randomly assigned to four groups: group 1 [0.9% saline solution (control]); group 2 [2.5% sodium hypochlorite (NaOCl)]; group 3 [17% ethylenediaminetetraacetic acid (EDTA) followed by 2.5% NaOCl]; and group 4 (7% MA followed by 2.5% NaOCl). Self-adhesive resin cement was used to test the adhesion of a glass-fibre post to the root dentine through a micropush-out test...
August 7, 2017: European Journal of Oral Sciences
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