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Maleic acid

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https://www.readbyqxmd.com/read/29132223/comparison-of-the-relative-stability-of-pharmaceutical-cocrystals-consisting-of-paracetamol-and-dicarboxylic-acids
#1
Naoto Suzuki, Masatoshi Kawahata, Kentaro Yamaguchi, Toyofumi Suzuki, Kazuo Tomono, Toshiro Fukami
OBJECTIVE: The aim of this study is to evaluated evaluated the relative stability of pharmaceutical cocrystals consisting of paracetamol (APAP) and oxalic acid (OXA) or maleic acid (MLA). SIGNIFICANCE: These observations of cocrystal stability under various conditions are useful coformer criteria when cocrystals are selected as the API in drug development. METHOD: The relative stability was determined from the preferentially formed cocrystals under various conditions...
November 13, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29130556/effect-of-novel-chelating-agents-on-the-push-out-bond-strength-of-calcium-silicate-cements-to-the-simulated-root-end-cavities
#2
Nidambur Vasudev Ballal, Özgür İlke Ulusoy, Shubha Chhaparwal, Kishore Ginjupalli
To compare the effects of different chelating agents on the push-out bond strength of calcium silicate-based cements to the simulated root-end cavities. Root-end cavities were prepared on the roots of fifty extracted maxillary anterior teeth. The specimens were then randomly divided into 5 groups (n = 10) based on the final irrigation regimen: Group 1: 17% EDTA, Group 2: 7% maleic acid, Group 3: QMix, Group 4: 2.25% peracetic acid (PAA), Group 5: 0.9% saline. Then, the samples from each group were subdivided into two groups (n = 5) based on the apical filling material...
November 11, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29126370/evaluation-of-final-irrigation-regimens-with-maleic-acid-for-smear-layer-removal-and-wettability-of-root-canal-sealer
#3
Nidambur Vasudev Ballal, Carmen Maria Ferrer-Luque, Mrunali Sona, K Narayan Prabhu, Teresa Arias-Moliz, Pilar Baca
OBJECTIVE: To evaluate the smear layer removal and wettability of AH Plus sealer on root canal dentin treated with MA (maleic acid), MA + CTR (cetrimide) and MA + CTR + CHX (chlorhexidine) as final irrigating regimens. MATERIAL AND METHODS: For smear layer removal, 40 teeth were instrumented to size F4 and divided into four groups: (1) 7% MA, (2) 7% MA + 0.2% CTR, (3) 7% MA + 0.2% CTR + 2% CHX, (4) distilled water (control). After irrigation, teeth were subjected to SEM analysis...
November 10, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29112926/fabrication-of-mn3o4-carbon-nanotube-composites-with-high-areal-capacitance-using-cationic-and-anionic-dispersants
#4
M S Ata, J Milne, I Zhitomirsky
Mn3O4-multiwalled carbon nanotube (MWCNT) electrodes for supercapacitors with high active mass loadings have been fabricated with the goal of achieving a high area normalized capacitance (CS) and enhanced capacitance retention at high charge-discharge rates. Poly(4-styrenesulfonic acid-co-maleic acid) sodium salt P(SSA-MA) was used as a charging and dispersing agent for the fabrication of Mn3O4. The unique bonding properties of the MA monomers allowed efficient P(SSA-MA) adsorption on Mn3O4, whereas SSA monomers imparted a negative charge...
October 31, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29103514/synthesis-and-characterization-of-cassava-starch-with-maleic-acid-derivatives-by-etherification-reaction
#5
Samuel H Clasen, Carmen M O Müller, Alexandre L Parize, Alfredo T N Pires
Cassava starch was grafted with three different esters by the etherification reaction and its modification was characterized by (1)H NMR, FTIR, DSC, SEM, XDR, contact angle and SLS. The samples grafted with diethyl maleate, dipropyl maleate, and dibutyl maleate showed DS values of 2.3, 1.0 and 2.0, respectively, determined from (1)H NMR analysis and confirmed by FTIR analysis, with the appearance of bands at 1721, 1550 and 1126cm(-1). The FTIR, XRD, SEM and DSC results indicated a change in the intra and intermolecular hydrogen interactions in the grafted starch when compared to native starch...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29073142/elevation-in-and-persistence-of-multiple-urinary-biomarkers-indicative-of-oxidative-dna-stress-and-inflammation-toxicological-implications-of-maleic-acid-consumption-using-a-rat-model
#6
Charlene Wu, Hsin-Chang Chen, Shu-Ting Chen, Su-Yin Chiang, Kuen-Yuh Wu
Maleic acid (MA), an intermediate reagent used in many industrial products, instigated public health concerns in Taiwan when it was used to adulterate an array of starch-based delicacies to improve texture and storage time. Established studies reported that exposure to high concentrations of MA induce renal injury; little is known whether oxidative stress is induced at a relative low dose. This study aims to investigate the effect of oral single dose exposure of MA on the status of oxidative stress and inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/29072338/determination-of-lipid-bilayer-affinities-and-solvation-characteristics-by-electrokinetic-chromatography-using-polymer-bound-lipid-bilayer-nanodiscs
#7
William M Penny, Christopher P Palmer
Styrene-maleic acid polymer-bound lipid bilayer nanodiscs have been investigated and characterized by electrokinetic chromatography. Linear solvation energy relationship analysis was employed to characterize the changes in solvation environment of nanodiscs of varied belt to lipid ratio, belt polymer chemistry and molecular weight, and lipid composition. Increases in the lipid to belt polymer ratio resulted in smaller, more cohesive nanodiscs with greater electrophoretic mobility. Nanodisc structures with belt polymers of different chemistry and molecular weight were compared and showed only minor changes in solvent characteristics and selectivity consistent with changes in structure of the lipid bilayer...
October 26, 2017: Electrophoresis
https://www.readbyqxmd.com/read/29068516/simultaneous-determination-of-furfural-and-its-degradation-products-furoic-acid-and-maleic-acid-in-transformer-oil-by-the-reversed-phase-vortex-assisted-liquid-liquid-microextraction-followed-by-hplc
#8
Yifan Wang, Haiyan Li, Zhen Yang, Weijie Zhang, Jia Hua
To explore why the use of furfural as a transformer oil-paper insulation aging characteristic is problematic in real world application, we developed a method for the simultaneous determination of furfural, furoic acid and maleic acid in transformer oil by reversed-phase vortex-assisted liquid-liquid microextraction combined with high-performance liquid chromatography. The conditions for the proposed method were optimized, and the obtained extract can be directly analyzed by high-performance liquid chromatography...
October 25, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29056560/membrane-biology-visualized-in-nanometer-sized-discs-formed-by-styrene-maleic-acid-polymers
#9
REVIEW
Mansoore Esmaili, Michael Overduin
Discovering how membrane proteins recognize signals and passage molecules remains challenging. Life depends on compartmentalizing these processes into dynamic lipid bilayers that are technically difficult to work with. Several polymers have proven adept at separating the responsible machines intact for detailed analysis of their structures and interactions. Styrene maleic acid (SMA) co-polymers efficiently solubilize membranes into native nanodiscs and, unlike amphipols and membrane scaffold proteins, require no potentially destabilizing detergents...
October 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29049865/interrogating-membrane-protein-conformational-dynamics-within-native-lipid-compositions
#10
Eamonn Reading, Zoe Hall, Chloe Martens, Tabasom Haghighi, Heather Findlay, Zainab Ahdash, Argyris Politis, Paula J Booth
Membrane protein-lipid interplay is important for cellular function, however, tools enabling the interrogation of protein dynamics within native lipid environments are scarce and often invasive. We establish that the styrene-maleic acid anhydride lipid particle (SMALP) technology can be coupled with hydrogen-deuterium exchange mass spectrometry (HDX-MS) to investigate membrane protein conformational dynamics within native lipid bilayers. We demonstrate changes in accessibility and dynamics of the rhomboid protease, GlpG, captured within three different native lipid compositions, and identify protein regions sensitive to changes in the native lipid environment...
October 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29046858/fabrication-of-poly-styrene-co-maleic-anhydride-ag-spheres-with-high-surface-charge-intensity-and-their-self-assembly-into-photonic-crystal-films
#11
Jiajie Bi, Genrui Fan, Suli Wu, Xin Su, Hongbo Xia, Shu-Fen Zhang
Herein, we developed a method to prepare monodisperse poly(styrene-co-maleic anhydride)@Ag (PSMA@Ag) core-shell microspheres with high surface charge intensity by using an in situ reduction method. In this method, ethylenediamine tetraacetic acid tetrasodium salt (Na4EDTA) was used as a reducing agent to promote the growth of Ag, and at the same time endowed the PSMA@Ag spheres with a surface charge. The monodispersity of PSMA and PSMA@Ag and the ordered array of the photonic crystal films were characterized by using SEM...
October 2017: ChemistryOpen
https://www.readbyqxmd.com/read/29042771/styrene-maleic-acid-encapsulated-rl71-micelles-suppress-tumor-growth-in-a-murine-xenograft-model-of-triple-negative-breast-cancer
#12
Orleans Martey, Mhairi Nimick, Sebastien Taurin, Vignesh Sundararajan, Khaled Greish, Rhonda J Rosengren
Patients with triple negative breast cancer have a poor prognosis due in part to the lack of targeted therapies. In the search for novel drugs, our laboratory has developed a second-generation curcumin derivative, 3,5-bis(3,4,5-trimethoxybenzylidene)-1-methylpiperidine-4-one (RL71), that exhibits potent in vitro cytotoxicity. To improve the clinical potential of this drug, we have encapsulated it in styrene maleic acid (SMA) micelles. SMA-RL71 showed improved biodistribution, and drug accumulation in the tumor increased 16-fold compared to control...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29039196/a-mitochondria-targeted-ratiometric-biosensor-for-ph-monitoring-and-imaging-in-living-cells-with-congo-red-functionalized-dual-emission-semiconducting-polymer-dots
#13
Junyong Sun, Pinghua Ling, Feng Gao
The accurate and sensitive monitoring and imaging of mitochondrial pH in living cells play vital roles in chemical biology and biomedicine. Herein, we design a novel ratiometric fluorescent chemical probe for monitoring and imaging the pH of mitochondria in living cells based on congo-red (CR)-modified dual-emission semiconducting polymer dots (Pdots) via a competitive fluorescence resonance energy transfer (FRET) mechanism. The Pdots are synthesized by triphenylphosphonium (TPP)-modified polyoxyethylene nonylphenylether (CO-520), poly(9,9-dioctylfluorenyl-2,7-diyl) (PFO), poly(9,9-dioctylfluorene)-co-(4,7-di-2-thienyl-2,1,3-benzothiadiazole) (PF-DBT5), and poly(styrene-co-maleic anhydride) (PSMA) via a nanoprecipitation method, and the prepared Pdots are further chemically linked with pH-sensitive, nonfluorescent CR to obtain the mitochondria-targeted pH fluorescent probes...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28994595/pertechnetate-induced-addition-of-sulfide-in-small-olefinic-acids-formation-of-tco-dimercaptosuccinate-2-5-and-tco-mercaptosuccinate-2-3-analogues
#14
Kimberly M Reinig, Rachel Seibert, Daniel Velazquez, Jakob Baumeister, Firouzeh Najafi Khosroshahi, Wei Wycoff, Jeff Terry, John E Adams, Carol A Deakyne, Silvia S Jurisson
Technetium-99 ((99)Tc) is important to the nuclear fuel cycle as a long-lived radionuclide produced in ∼6% fission yield from (235)U or (239)Pu. In its most common chemical form, namely, pertechnetate ((99)TcO4(-)), it is environmentally mobile. In situ hydrogen sulfide reduction of pertechnetate has been proposed as a potential method to immobilize environmental (99)TcO4(-) that has entered the environment. Reactions of (99)TcO4(-) with sulfide in solution result in the precipitation of Tc2S7 except when olefinic acids, specifically fumaric or maleic acid, are present; a water-soluble (99)Tc species forms...
November 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28993151/using-a-smalp-platform-to-determine-a-sub-nm-single-particle-cryo-em-membrane-protein-structure
#15
Mayuriben Parmar, Shaun Rawson, Charlotte A Scarff, Adrian Goldman, Timothy R Dafforn, Stephen P Muench, Vincent L G Postis
The field of membrane protein structural biology has been revolutionized over the last few years with a number of high profile structures being solved using cryo-EM including Piezo, Ryanodine receptor, TRPV1 and the Glutamate receptor. Further developments in the EM field hold the promise of even greater progress in terms of greater resolution, which for membrane proteins is still typically within the 4-7Å range. One advantage of a cryo-EM approach is the ability to study membrane proteins in more "native" like environments for example proteoliposomes, amphipols and nanodiscs...
October 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28948523/enhanced-stability-of-gold-magnetic-nanoparticles-with-poly-4-styrenesulfonic-acid-co-maleic-acid-tailored-optical-properties-for-protein-detection
#16
Xiaomei Zhang, Qinlu Zhang, Ting Ma, Qian Liu, Songdi Wu, Kai Hua, Chao Zhang, Mingwei Chen, Yali Cui
Gold magnetic nanoparticles (GoldMag) have attracted great attention due to their unique physical and chemical performances combining those of individual Fe3O4 and Au nanoparticles. Coating GoldMag with polymers not only increases the stability of the composite particles suspended in buffer but also plays a key role for establishing point-of-care optical tests for clinically relevant biomolecules. In the present paper, poly(4-styrenesulfonic acid-co-maleic acid) (PSS-MA), a negatively charged polyelectrolyte with both sulfonate and carboxylate anionic groups, was used to coat the positively charged GoldMag (30 nm) surface...
September 25, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28943768/quality-characteristics-of-tteokgalbi-with-black-rice-bran-and-organic-acid-to-substitute-synthetic-caramel-colorant
#17
Tae-Kyung Kim, Seung-Hee Hong, Su-Kyung Ku, Young-Boong Kim, Ki-Hong Jeon, Hee-Don Choi, Jong-Dae Park, Kwoan-Sik Park, Yun-Sang Choi
This study aimed to evaluate the quality characteristics of Tteokgalbi with 1% (w/w) black rice bran only (T1), or with black rice bran and one of the following four types of organic acid: ascorbic acid (T2), citric acid (T3), tartaric acid (T4), or maleic acid (T5) as a substitute for caramel colorant. Tteokgalbi with only black rice bran showed the highest (p<0.05) values of moisture content and water holding capacity (WHC), while there were no significant differences in protein content, fat content, ash content, and thiobarbituric acid reactive substance (TBARS) values in treatments and controls (p>0...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28941914/a-novel-approach-in-acidic-disinfection-through-inhibition-of-acid-resistance-mechanisms-maleic-acid-mediated-inhibition-of-glutamate-decarboxylase-activity-enhances-acid-sensitivity-of-listeria-monocytogenes
#18
Ranju Paudyal, Ruth H Barnes, Kimon Andreas G Karatzas
Here it is demonstrated a novel approach in disinfection regimes where specific molecular acid resistance systems are inhibited aiming to eliminate microorganisms under acidic conditions. Despite the importance of the Glutamate Decarboxylase (GAD) system for survival of Listeria monocytogenes and other pathogens under acidic conditions, its potential inhibition by specific compounds that could lead to its elimination from foods or food preparation premises has not been studied. The effects of maleic acid on the acid resistance of L...
February 2018: Food Microbiology
https://www.readbyqxmd.com/read/28934548/controlling-styrene-maleic-acid-lipid-particles-through-raft
#19
Anton A A Smith, Henriette E Autzen, Tomas Laursen, Vincent Wu, Max Yen, Aaron Hall, Scott D Hansen, Yifan Cheng, Ting Xu
The ability of styrene maleic acid copolymers to dissolve lipid membranes into nanosized lipid particles is a facile method of obtaining membrane proteins in solubilized lipid discs while conserving part of their native lipid environment. While the currently used copolymers can readily extract membrane proteins in native nanodiscs, their highly disperse composition is likely to influence the dispersity of the discs as well as the extraction efficiency. In this study, reversible addition-fragmentation chain transfer was used to control the polymer architecture and dispersity of molecular weights with a high-precision...
October 9, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28930432/injectable-stem-cell-laden-open-porous-microgels-that-favor-adipogenesis-in-vitro-and-in-vivo-evaluation
#20
Pengfei Xia, Kunxi Zhang, Yan Gong, Guifei Li, Shifeng Yan, Jingbo Yin
Microgels, with large surface area per volume, show great advantages in adipose tissue engineering due to their injectability and similarity with natural extracellular matrix. However, to date, no studies have tried applying microgels to adipose tissue regeneration. Herein, based on double-bonded poly(l-glutamic acid)-g-2-hydroxyethyl methacrylate (PLGA-g-HEMA) and maleic anhydride-modified chitosan (MCS), an open porous microgel with high hydrophilicity and great injectability is successfully prepared (microgels diameters of 200-300 μm, pore diameter of 38 μm, and porosity of 88...
October 11, 2017: ACS Applied Materials & Interfaces
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