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https://www.readbyqxmd.com/read/29353081/hydrogels-based-on-poly-methyl-vinyl-ether-co-maleic-acid-and-tween-85-for-sustained-delivery-of-hydrophobic-drugs
#1
Eneko Larrañeta, Laura Barturen, Michael Ervine, Ryan F Donnelly
Hydrogels based on poly(methyl vinyl ether-co-maleic acid) and Tween 85 were prepared for hydrophobic drug delivery. The hydrogels were synthesized following a simple procedure carried out in solid state. The process did not require the use of any solvent and, as it is based on an esterification reaction, no toxic by-products were obtained. The resulting hydrogels contained Tween 85 inside the structure and due to the amphiphilic nature of this compound, hydrophobic domains within the hydrogel structure were formed...
January 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29346393/computational-study-of-hiv-gp120-as-a-target-for-polyanionic-entry-inhibitors-exploiting-the-v3-loop-region
#2
Louis R Hollingsworth, Anne M Brown, Richard D Gandour, David R Bevan
Multiple approaches are being utilized to develop therapeutics to treat HIV infection. One approach is designed to inhibit entry of HIV into host cells, with a target being the viral envelope glycoprotein, gp120. Polyanionic compounds have been shown to be effective in inhibiting HIV entry, with a mechanism involving electrostatic interactions with the V3 loop of gp120 being proposed. In this study, we applied computational methods to elucidate molecular interactions between the repeat unit of the precisely alternating polyanion, Poly(4,4'-stilbenedicarboxylate-alt-maleic acid) (DCSti-alt-MA) and the V3 loop of gp120 from strains of HIV against which these polyanions were previously tested (IIIb, BaL, 92UG037, JR-CSF) as well as two strains for which gp120 crystal structures are available (YU2, 2B4C)...
2018: PloS One
https://www.readbyqxmd.com/read/29335807/assessment-of-in-vitro-cytotoxic-and-genotoxic-activities-of-some-trimethoprim-conjugates
#3
Devrim Güzel Bayülken, R Beklem Bostancıoğlu, A Tansu Koparal, Berrin Ayaz Tüylü, Aydan Dağ, Kadriye Benkli
Trimethoprim, a commonly used antibacterial agent, is widely applied in the treatment of variety of infections in human. A few studies have demonstrated an extensive exposure of man to antibiotics, but there is still a lack of data for cytotoxic effects including nephrotoxicity, gastrointestinal toxicity, hematotoxicity, neurotoxicity and ototoxicity. The main purpose behind this study was to determine cytotoxic and genotoxic activities of trimethoprim (1), trimethoprim with maleic acid (2) and trimethoprim in conjugation with oxalic acid dihydrate (3)...
January 15, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29330941/hydrophobic-and-hydrophilic-effects-on-water-structuring-and-adhesion-in-denture-adhesives
#4
Simrone K Gill, Nima Roohpour, Yiran An, Julien E Gautrot, Paul D Topham, Brian J Tighe
Denture adhesives are designed to be moisture-sensitive through the inclusion of a blend of polymer salts with varying degrees of water-sensitivity. This enables the adhesive to mix with saliva in vivo and activate its high tack, through the formation of a mucilaginous layer. We report for the first time, the use of differential scanning calorimetry (DSC) to study a series of hydrophobic and hydrophilic polymeric systems in order to correlate water-structuring behavior with adhesion strength. Adhesive bonding of the more hydrophobic variants was higher than that of a commercial-based control and a more hydrophilic polymer system in both lap shear and tensile configurations...
January 13, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29316667/uv-vis-induced-degradation-of-phenol-over-magnetic-photocatalysts-modified-with-pt-pd-cu-and-au-nanoparticles
#5
Izabela Wysocka, Ewa Kowalska, Konrad Trzciński, Marcin Łapiński, Grzegorz Nowaczyk, Anna Zielińska-Jurek
The combination of TiO₂ photocatalyst and magnetic oxide nanoparticles enhances the separation and recoverable properties of nanosized TiO₂ photocatalyst. Metal-modified (Me = Pd, Au, Pt, Cu) TiO₂/SiO₂@Fe₃O₄ nanocomposites were prepared by an ultrasonic-assisted sol-gel method. All prepared samples were characterized by X-ray powder diffraction (XRD) analysis, Brunauer-Emmett-Teller (BET) method, X-ray photoelectron spectroscopy (XPS), scanning transmission electron microscopy (STEM), Mott-Schottky analysis and photoluminescence spectroscopy (PL)...
January 7, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29291373/probing-the-local-lipid-environment-of-the-rhodobacter-sphaeroides-cytochrome-bc1-and-synechocystis-sp-pcc-6803-cytochrome-b6f-complexes-with-styrene-maleic-acid
#6
David J K Swainsbury, Matthew S Proctor, Andrew Hitchcock, Michaël L Cartron, Pu Qian, Elizabeth C Martin, Philip J Jackson, Jeppe Madsen, Steven P Armes, C Neil Hunter
Intracytoplasmic vesicles (chromatophores) in the photosynthetic bacterium Rhodobacter sphaeroides represent a minimal structural and functional unit for absorbing photons and utilising their energy for the generation of ATP. The cytochrome bc1 complex (cytbc1) is one of the four major components of the chromatophore alongside the reaction centre-light harvesting 1-PufX core complex (RC-LH1-PufX), the light-harvesting 2 complex (LH2), and ATP synthase. Although the membrane organization of these complexes is known, their local lipid environments have not been investigated...
December 29, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29273333/modifying-styrene-maleic-acid-co-polymer-for-studying-lipid-nanodiscs
#7
Victoria Schmidt, James N Sturgis
Recently, styrene-maleic acid copolymer lipid nanodiscs have become an increasingly popular tool for the study of membrane proteins. In the work we report here, we have developed a novel method for the efficient preparation of labeled nanodiscs, under chemically mild conditions, by modification of the hydrolyzed styrene-maleic acid copolymer. This protocol is designed to be easily accessible to biochemistry laboratories. We use this procedure to prepare various fluorescent nanodiscs labeled with different fluorophores...
December 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29251531/micellar-formulations-of-crizotinib-and-dasatinib-in-the-management-of-glioblastoma-multiforme
#8
Khaled Greish, Anfal Jasim, Neha Parayath, Sara Abdelghany, Ali Alkhateeb, Sebastien Taurin, Hayley Nehoff
Glioblastoma multiforme (GBM) defies the currently practiced management of radiotherapy, chemotherapy and surgery and hence, it is associated with a high fatality rate with a median survival of 14.6 months. In our previous work investigating different tyrosine kinase inhibitors (TKIs), we established that a combination of Crizotinib and Dasatinib exerted the most potent effect on different GBM cell lines. In the current work, to improve targeted therapy at the site of the tumor and avoid systemic toxicity, we exploited the enhanced permeability and retention effect by designing micellar formulations of these two TKIs...
December 18, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29243400/highly-efficient-gas-phase-oxidation-of-renewable-furfural-to-maleic-anhydride-over-plate-vpo-catalyst
#9
Yugen Zhang, Xiukai Li, Jogie Ko
Maleic anhydride (MAnh) and its acids are critical intermediates in chemical industry. The synthesis of maleic anhydride from renewable furfural is one of the most sought after processes in the field of sustainable chemistry. We report a plate vanadium phosphorous oxide (VPO) catalyst synthesized by a hydrothermal method with glucose as a green reducing agent for furfural oxidation to MAnh in gas phase. The plate VPOHT catalyst has a preferentially exposed 200 crystal plane and exhibited dramatically enhanced activity, selectivity and stability as compared to conventional VPO catalysts and other state-of-the-art catalytic systems...
December 15, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29232017/ph-resistant-monodispersed-polymer-lipid-nanodiscs
#10
Thirupathi Ravula, Nathaniel Z Hardin, Sudheer Ramadugu, Sarah J Cox, Ayyalusamy Ramamoorthy
Polymer lipid nanodiscs have provided an invaluable system for structural and functional studies of membrane proteins in their near-native environment. In spite of the recent advances in the development and usage of polymer lipid nanodisc systems, lack of control over size and poor tolerance to pH and divalent metal ions are major limitations for further applications. Here we report a facile modification of a low molecular weight styrene maleic acid copolymer to form monodispersed lipid bilayer nanodiscs that show ultra-stability towards a pH range of 2...
December 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29222482/poly-methyl-vinyl-ether-alt-maleic-acid-and-ethyl-monoester-as-building-polymers-for-drug-loadable-electrospun-nanofibers
#11
Amalia Mira, C Reyes Mateo, Ricardo Mallavia, Alberto Falco
New biomaterials are sought for the development of bioengineered nanostructures. In the present study, electrospun nanofibers have been synthesized by using poly(methyl vinyl ether-alt-maleic acid) and poly(methyl vinyl ether-alt-maleic ethyl monoester) (PMVEMA-Ac and PMVEMA-ES, respectively) as building polymers for the first time. To further functionalize these materials, nanofibers of PMVEMA-Ac and PMVEMA-ES containing a conjugated polyelectrolyte (HTMA-PFP, blue emitter, and HTMA-PFNT, red emitter) were achieved with both forms maintaining a high solid state fluorescence yield without altered morphology...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29210511/enhanced-fluorescence-properties-of-stilbene-containing-alternating-copolymers
#12
Jing Huang, Xi Geng, Chong Peng, Tijana Z Grove, S Richard Turner
In recent years, nonconjugated, fluorophore-free organic polymers have emerged as potentially useful light-emitting materials. The fluorescence properties of a novel class of nonconjugated, tert-butyl carboxylate functionalized stilbene-containing alternating copolymers are investigated in this work. These sterically crowded, semi-rigid copolymers exhibit very strong blue fluorescence in organic solvents upon irradiation. The origin of the fluorescent band with high quantum yield is attributed to the "through space" π-π interactions between the phenyl rings from the stilbene and CO groups from the anhydride groups...
December 6, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29207463/synthesis-and-characterization-of-polyaniline-graphene-composite-nanofiber-and-its-application-as-an-electrochemical-dna-biosensor-for-the-detection-of-mycobacterium-tuberculosis
#13
Fatimah Syahidah Mohamad, Mohd Hazani Mat Zaid, Jaafar Abdullah, Ruzniza Mohd Zawawi, Hong Ngee Lim, Yusran Sulaiman, Norizah Abdul Rahman
This article describes chemically modified polyaniline and graphene (PANI/GP) composite nanofibers prepared by self-assembly process using oxidative polymerization of aniline monomer and graphene in the presence of a solution containing poly(methyl vinyl ether-alt-maleic acid) (PMVEA). Characterization of the composite nanofibers was carried out by Fourier transform infrared (FTIR) and Raman spectroscopy, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). SEM images revealed the size of the PANI nanofibers ranged from 90 to 360 nm in diameter and was greatly influenced by the proportion of PMVEA and graphene...
December 2, 2017: Sensors
https://www.readbyqxmd.com/read/29196024/poly-methyl-vinyl-ether-co-maleic-acid-for-enhancement-of-solubility-oral-bioavailability-and-anti-osteoporotic-effects-of-raloxifene-hydrochloride
#14
J Varshosaz, Mohsen Minayian, Ladan Dayyani
Raloxifene HCl (RH) has poor water solubility and due to its extensive first pass metabolism; its bioavailability is only 2%. The purpose of the present study was to enhance the aqueous solubility, oral bioavailability and anti-osteoporotic effects of RH by electro-sprayed nanoparticles (NPs) in ovariectomized rats. NPs containing RH and different ratio of poly(methyl vinyl ether-co-maleic acid) (PMVEMA) were electrosprayed. The voltage, distance of needle to the collector, flow rate of the solution and polymeric percentage were optimized according to the size of NPs and drug solubility...
November 28, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29181755/application-of-the-fenton-s-process-in-a-bubble-column-reactor-for-hydroquinone-degradation
#15
Vanessa N Lima, Carmen S D Rodrigues, Luis M Madeira
The aim of this study was to assess the degradation and mineralization of hydroquinone (HQ) by the Fenton's process in a bubble column reactor (BCR). The effect of the main operating variables, namely, air flow rate, effluent volume, hydrogen peroxide (H2O2) concentration, catalyst (Fe2+) dose, initial pH, and temperature, were assessed. For all air flow rates tested, no concentration gradients along the column were noticed, evidencing that a good mixing was reached in the BCR. For the best conditions tested ([H2O2] = 500 mg/L, [Fe2+] = 45 mg/L, T = 24 °C, Q air = 2...
November 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29177974/antitumor-activity-of-raloxifene-targeted-poly-styrene-maleic-acid-poly-amide-ether-ester-imide-co-polymeric-nanomicelles-loaded-with-docetaxel-in-breast-cancer-bearing-mice
#16
Saeede Enteshari, Jaleh Varshosaz, Mohsen Minayian, Farshid Hassanzadeh
Purpose Raloxifene (RA) receptors have over-expressed GPER-positive breast cancer tumors. The purpose of this work was to evaluate the antitumor activity and pharmacokinetic behavior of docetaxel (DTX), loaded in RA-targeted nanomicelles, which were designed to overcome a lack of specific distribution and inadequate DTX concentration in tumor tissues, as well as its cytotoxicity and damage to normal tissues. Methods DTX-loaded RA-targeted poly(styrene maleic acid) (SMA)- poly(amide-ether-esterimide)-poly(ethylene glycol) (PAEEI-PEG) nanomicelles were prepared; then, their antitumor activity and survival rate were studied in MC4-L2 tumors induced in BALB/c mice...
November 27, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29171792/preparation-and-characteristics-of-the-sulfonated-chitosan-derivatives-electrodeposited-onto-316l-stainless-steel-surface
#17
Ye Huang, Guangjia Peng, Bin Chen, Ping Yong, Nan Yao, Liming Yang, Rogério P Pirraco, Rui L Reis, Jie Chen
In order to ameliorate the properties of corrosion resistance and achieve applications in anti-biofouling of 316L stainless steel (SS), a sulfated derivative of chitosan was deposited onto stainless steel surface by an electrochemical method. In detail, chitosan-catechol (CS-CT) was synthesized in the hydrochloric acid solution by the Mannich reaction and then electrodeposited on the surface of the polished 316L stainless steel. The chitosan-catechol deposited SS sample was further modified with maleic anhydride and sulfite...
November 24, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29171274/spontaneous-lipid-nanodiscs-fomation-by-amphiphilic-polymethacrylate-copolymers
#18
Kazuma Yasuhara, Jin Arakida, Thirupathi Ravula, Sudheer Kumar Ramadugu, Bikash Sahoo, Jun-Ichi Kikuchi, Ayyalusamy Ramamoorthy
There is a growing interest in the use of lipid bilayer nanodiscs for various biochemical and biomedical applications. Among the different types of nanodiscs, the unique features of synthetic polymer-based nanodiscs have attracted additional interest. A styrene-maleic acid (SMA) copolymer demonstrated to form lipid nanodiscs have been used for structural biology related studies on membrane proteins. However, the application of SMA polymer based lipid nanodiscs is limited because of the strong absorption of the aromatic group interfering with various experimental measurements...
November 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29169116/p-nitrophenol-degradation-by-fenton-s-oxidation-in-a-bubble-column-reactor
#19
Carmen S D Rodrigues, Ricardo A C Borges, Vanessa N Lima, Luis M Madeira
This paper reports on a study of the oxidation of p-nitrophenol (PNP) in a bubble column reactor (BCR). The use of the air stream aimed to provide perfect mixing in the liquid phase, which was successfully achieved and checked experimentally; there were no concentration gradients along the column, even at the lowest air flow rate used (Q = 1 mL/min at room temperature and atmospheric pressure). The effect of the operating variables was assessed, and a total reduction of PNP was reached, as well as mineralization of 49...
November 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29165359/environmentally-friendly-compatibilizers-from-soybean-oil-for-ternary-blends-of-poly-lactic-acid-pla-poly-%C3%AE%C2%B5-caprolactone-pcl-and-poly-3-hydroxybutyrate-phb
#20
María Jesús Garcia-Campo, Luis Quiles-Carrillo, Jaime Masia, Miguel Jorge Reig-Pérez, Nestor Montanes, Rafael Balart
Ternary blends of poly(lactic acid) (PLA), poly(3-hydroxybutyrate) (PHB) and poly(ε-caprolactone) (PCL) with a constant weight percentage of 60%, 10% and 30% respectively were compatibilized with soybean oil derivatives epoxidized soybean oil (ESO), maleinized soybean oil (MSO) and acrylated epoxidized soybean oil (AESO). The potential compatibilization effects of the soybean oil-derivatives was characterized in terms of mechanical, thermal and thermomechanical properties. The effects on morphology were studied by field emission scanning electron microscopy (FESEM)...
November 22, 2017: Materials
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