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Maleic acid

Alfredo Briones-Herrera, Sabino Hazael Avila-Rojas, Omar Emiliano Aparicio-Trejo, Magdalena Cristóbal, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Enrique Pinzón, José Pedraza-Chaverri, Laura Gabriela Sánchez-Lozada, Edilia Tapia
Maleic acid (MA)-induced nephropathy that is characterized by proteinuria, glycosuria, phosphaturia and a deficient urinary acidification and concentration. Sulforaphane (SF) is an indirect antioxidant that shows nephroprotective effects. The aim of the present work was to test the pre-treatment with SF against the MA-induced nephropathy. Wistar rats (230-260 g) were separated in the following groups: control, MA (which received 400 mg/kg of MA), SF + MA (which received MA and 1 mg/kg of SF each day for four days) and SF (which only received SF)...
March 13, 2018: Food and Chemical Toxicology
Dipendra Gyawali, Jimin P Kim, Jian Yang
A novel photo-crosslinkable nanogel is prepared from a biodegradable polymer template with intrinsic photoluminescence and high photostability. The fluorescent nanogels display excellent biodegradability and cytocompatibility owed to the facile synthesis scheme involving a solvent-and surfactant-free one-pot reaction, derived entirely from biocompatible monomers citric acid, maleic acid, L-cysteine, and poly(ethylene glycol). The resultant nanogels are less than 200 nm in diameter with a narrow size distribution and monodispersity, and demonstrate long-term structural stability in biological buffer for two weeks...
March 2018: Bioactive Materials
Anne Grethen, David Glueck, Sandro Keller
Styrene/maleic acid (SMA) and related copolymers are attracting great interest because they solubilise membrane proteins and lipids to form polymer-encapsulated nanodiscs. These nanodiscs retain a lipid-bilayer core surrounded by a polymer rim and can harbour a membrane protein or a membrane-protein complex. SMA exists in different styrene/maleic acid molar ratios, which results in differences in hydrophobicity and solubilisation properties. We have recently demonstrated fast collisional lipid transfer among nanodiscs encapsulated by the relatively hydrophobic copolymer SMA(3:1)...
March 5, 2018: Journal of Membrane Biology
Lingxian Ye, Guangying Zhao, Wenchao Dou
A sensitive Point-of-Care Testing (POCT) with Au-Pt bimetallic nanoparticles (Au@Pt) functionalized silica nanoparticle (SiO2 NPs) and Fe3 O4 magnetic nanoparticles (Fe3 O4 NPs) was designed for the quantitative detection of Escherichia coli O157:H7 (E. coli O157:H7). The poly-(4-styrenesulfonic acid-co-maleic acid) (PSSMA) as a negatively charged polyelectrolyte can be easily coated on surface of the amino group modified SiO2 NPs via electrostatic force. PSSMA is also a good stabilizer for water-soluble bimetallic nanostructures...
May 15, 2018: Talanta
Xinxin Liu, Tao Song, Minmin Chang, Ling Meng, Xiaohui Wang, Runcang Sun, Junli Ren
Introducing multifunctional groups and inorganic material imparts xylan-based hydrogels with excellent properties, such as responsiveness to pH, temperature, light, and external magnetic field. In this work, a composite hydrogel was synthesized by introducing acid treated carbon nanotubes (AT-CNTs) into the maleic anhydride modified xylan grafted with poly(N-isopropylacrylamide) (MAX-g-PNIPAM) hydrogels network. It was found that the addition of AT-CNTs affected the MAX-g-PNIPAM hydrogel structure, the swelling ratio and mechanical properties, and imparted the hydrogel with new properties of electrical conductivity and near infrared region (NIR) photothermal conversion...
February 28, 2018: Materials
Chunyu Zhang, Xiaoyan Dong, Zheng Guo, Yan Sun
Enzymes are promising biocatalysts for the production or degradation of chemical compounds, but low stabilities of free enzymes restrict their industrial applications. Therefore, development of effective immobilization methods to maintain or increase enzyme activity and stability remains a challenge. In this work, a novel support made of zwitterionic polymer-grafted silica nanoparticles (p-SNPs) was fabricated and Candida rugosa lipase (CRL) was covalently attached onto the p-SNPs. The zwitterionic polymer was a product of the reaction between poly(maleic anhydride-alt-1-octadecene) and N,N-dimethylenediamine and contained a cetane side chain...
February 14, 2018: Journal of Colloid and Interface Science
Moon-Sung Kang, Yong Soo Kang, Hyoung-Juhn Kim, Hak-Soo Han, Jin-Soo Park
Nanocomposite polymer electrolyte membranes comprising a crosslinked polymer blend of poly(vinyl alcohol)/poly(styrene sulfonic acid-co-maleic acid) (PVA/PSSA-co-MA) and fumed silica nanoparticles were prepared for direct methanol fuel cell (DMFC) applications. Silica nanoparticles could be incorporated well uniformly in the completely miscible system, which can form a three-dimensional network structure to achieve the enhancement of mechanical properties as well as the additional reduction of methanol permeability...
March 1, 2018: Journal of Nanoscience and Nanotechnology
Hamed Vakilzadeh, Jaleh Varshosaz, Mohsen Minaiyan
INTRODUCTION: Triptorelin the synthetic analog of gonadotrophin-releasing hormone is used for treatment of sex hormone dependent diseases via parenteral administration. The aim of the present study was investigation the possibility of triptorelin pulmonary delivery and preparation of a pulmonary nanocarrier delivery system for it. METHODS: Triptorelin was loaded in Pluronic-F127 grafted poly (methyl vinyl ether-alt-maleic acid) nanomicelles by direct dissolution method...
February 8, 2018: Current Drug Delivery
Padmaja Venkatakrishnan, Samir Benlekbir, Chang Sun, Sangjin Hong, Jonathan Hosler, John Rubinstein, Robert B Gennis
Alternative Complex III (ACIII) is a functional homolog of the bc1 complex that catalyzes quinol:cytochrome c oxidoreductase activity but has no structural similarities with the bc1 complex. In this work, we characterize the ACIII from the mesophile Flavobacterium johnsoniae, and isolate it as part of a supercomplex with the cytochrome aa3 oxygen reductase. We have solubilized and purified the supercomplex using a styrene maleic acid (SMA) copolymer that forms nanodiscs containing the entire supercomplex. The SMA nanodiscs are stable and are useful for various structural studies with the supercomplex including EPR spectroscopy and electron cryomicroscopy...
February 2, 2018: Biochimica et Biophysica Acta
Mohammed Selman, Paula Ou, Christopher Rousso, Anabel Bergeron, Ramya Krishnan, Larissa Pikor, Andrew Chen, Brian A Keller, Carolina Ilkow, John C Bell, Jean-Simon Diallo
Resistance to oncolytic virotherapy is frequently associated with failure of tumor cells to get infected by the virus. Dimethyl fumarate (DMF), a common treatment for psoriasis and multiple sclerosis, also has anticancer properties. We show that DMF and various fumaric and maleic acid esters (FMAEs) enhance viral infection of cancer cell lines as well as human tumor biopsies with several oncolytic viruses (OVs), improving therapeutic outcomes in resistant syngeneic and xenograft tumor models. This results in durable responses, even in models otherwise refractory to OV and drug monotherapies...
January 24, 2018: Science Translational Medicine
Eneko Larrañeta, Laura Barturen, Michael Ervine, Ryan F Donnelly
Hydrogels based on poly(methyl vinyl ether-co-maleic acid) and Tween 85 were prepared for hydrophobic drug delivery. The hydrogels were synthesized following a simple procedure carried out in solid state. The process did not require the use of any solvent and, as it is based on an esterification reaction, no toxic by-products were obtained. The resulting hydrogels contained Tween 85 inside the structure and due to the amphiphilic nature of this compound, hydrophobic domains within the hydrogel structure were formed...
January 15, 2018: International Journal of Pharmaceutics
Louis R Hollingsworth, Anne M Brown, Richard D Gandour, David R Bevan
Multiple approaches are being utilized to develop therapeutics to treat HIV infection. One approach is designed to inhibit entry of HIV into host cells, with a target being the viral envelope glycoprotein, gp120. Polyanionic compounds have been shown to be effective in inhibiting HIV entry, with a mechanism involving electrostatic interactions with the V3 loop of gp120 being proposed. In this study, we applied computational methods to elucidate molecular interactions between the repeat unit of the precisely alternating polyanion, Poly(4,4'-stilbenedicarboxylate-alt-maleic acid) (DCSti-alt-MA) and the V3 loop of gp120 from strains of HIV against which these polyanions were previously tested (IIIb, BaL, 92UG037, JR-CSF) as well as two strains for which gp120 crystal structures are available (YU2, 2B4C)...
2018: PloS One
Devrim Güzel Bayülken, R Beklem Bostancıoğlu, A Tansu Koparal, Berrin Ayaz Tüylü, Aydan Dağ, Kadriye Benkli
Trimethoprim, a commonly used antibacterial agent, is widely applied in the treatment of variety of infections in human. A few studies have demonstrated an extensive exposure of man to antibiotics, but there is still a lack of data for cytotoxic effects including nephrotoxicity, gastrointestinal toxicity, hematotoxicity, neurotoxicity and ototoxicity. The main purpose behind this study was to determine cytotoxic and genotoxic activities of trimethoprim (1), trimethoprim with maleic acid (2) and trimethoprim in conjugation with oxalic acid dihydrate (3)...
January 15, 2018: Cytotechnology
Simrone K Gill, Nima Roohpour, Yiran An, Julien E Gautrot, Paul D Topham, Brian J Tighe
Denture adhesives are designed to be moisture-sensitive through the inclusion of a blend of polymer salts with varying degrees of water-sensitivity. This enables the adhesive to mix with saliva in vivo and activate its high tack, through the formation of a mucilaginous layer. We report for the first time, the use of differential scanning calorimetry (DSC) to study a series of hydrophobic and hydrophilic polymeric systems in order to correlate water-structuring behavior with adhesion strength. Adhesive bonding of the more hydrophobic variants was higher than that of a commercial-based control and a more hydrophilic polymer system in both lap shear and tensile configurations...
January 13, 2018: Journal of Biomedical Materials Research. Part A
Izabela Wysocka, Ewa Kowalska, Konrad Trzciński, Marcin Łapiński, Grzegorz Nowaczyk, Anna Zielińska-Jurek
The combination of TiO₂ photocatalyst and magnetic oxide nanoparticles enhances the separation and recoverable properties of nanosized TiO₂ photocatalyst. Metal-modified (Me = Pd, Au, Pt, Cu) TiO₂/SiO₂@Fe₃O₄ nanocomposites were prepared by an ultrasonic-assisted sol-gel method. All prepared samples were characterized by X-ray powder diffraction (XRD) analysis, Brunauer-Emmett-Teller (BET) method, X-ray photoelectron spectroscopy (XPS), scanning transmission electron microscopy (STEM), Mott-Schottky analysis and photoluminescence spectroscopy (PL)...
January 7, 2018: Nanomaterials
David J K Swainsbury, Matthew S Proctor, Andrew Hitchcock, Michaël L Cartron, Pu Qian, Elizabeth C Martin, Philip J Jackson, Jeppe Madsen, Steven P Armes, C Neil Hunter
Intracytoplasmic vesicles (chromatophores) in the photosynthetic bacterium Rhodobacter sphaeroides represent a minimal structural and functional unit for absorbing photons and utilising their energy for the generation of ATP. The cytochrome bc1 complex (cytbc1) is one of the four major components of the chromatophore alongside the reaction centre-light harvesting 1-PufX core complex (RC-LH1-PufX), the light-harvesting 2 complex (LH2), and ATP synthase. Although the membrane organization of these complexes is known, their local lipid environments have not been investigated...
December 29, 2017: Biochimica et Biophysica Acta
Victoria Schmidt, James N Sturgis
Recently, styrene-maleic acid copolymer lipid nanodiscs have become an increasingly popular tool for the study of membrane proteins. In the work we report here, we have developed a novel method for the efficient preparation of labeled nanodiscs, under chemically mild conditions, by modification of the hydrolyzed styrene-maleic acid copolymer. This protocol is designed to be easily accessible to biochemistry laboratories. We use this procedure to prepare various fluorescent nanodiscs labeled with different fluorophores...
December 19, 2017: Biochimica et Biophysica Acta
Khaled Greish, Anfal Jasim, Neha Parayath, Sara Abdelghany, Ali Alkhateeb, Sebastien Taurin, Hayley Nehoff
Glioblastoma multiforme (GBM) defies the currently practiced management of radiotherapy, chemotherapy and surgery and hence, it is associated with a high fatality rate with a median survival of 14.6 months. In our previous work investigating different tyrosine kinase inhibitors (TKIs), we established that a combination of Crizotinib and Dasatinib exerted the most potent effect on different GBM cell lines. In the current work, to improve targeted therapy at the site of the tumor and avoid systemic toxicity, we exploited the enhanced permeability and retention effect by designing micellar formulations of these two TKIs...
December 18, 2017: Journal of Drug Targeting
Xiukai Li, Jogie Ko, Yugen Zhang
Maleic anhydride (MAnh) and its acids are critical intermediates in chemical industry. The synthesis of maleic anhydride from renewable furfural is one of the most sought after processes in the field of sustainable chemistry. In this study, a plate vanadium phosphorus oxide (VPO) catalyst synthesized by a hydrothermal method with glucose as a green reducing agent catalyzes furfural oxidation to MAnh in the gas phase. The plate catalyst-denoted as VPOHT -has a preferentially exposed (200) crystal plane and exhibited dramatically enhanced activity, selectivity and stability as compared to conventional VPO catalysts and other state-of-the-art catalytic systems...
February 9, 2018: ChemSusChem
Thirupathi Ravula, Nathaniel Z Hardin, Sudheer Kumar Ramadugu, Sarah J Cox, Ayyalusamy Ramamoorthy
Polymer lipid nanodiscs are an invaluable system for structural and functional studies of membrane proteins in their near-native environment. Despite the recent advances in the development and usage of polymer lipid nanodisc systems, lack of control over size and poor tolerance to pH and divalent metal ions are major limitations for further applications. A facile modification of a low-molecular-weight styrene maleic acid copolymer is demonstrated to form monodispersed lipid bilayer nanodiscs that show ultra-stability towards divalent metal ion concentration over a pH range of 2...
January 26, 2018: Angewandte Chemie
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