keyword
MENU ▼
Read by QxMD icon Read
search

Maleic acid

keyword
https://www.readbyqxmd.com/read/28191316/the-contraceptive-efficacy-of-intravas-injection-of-vasalgel%C3%A2-for-adult-male-rhesus-monkeys
#1
Angela Colagross-Schouten, Marie-Josee Lemoy, Rebekah I Keesler, Elaine Lissner, Catherine A VandeVoort
BACKGROUND: Options for male contraception are limited. The purpose of this study was to use a nonhuman primate model to evaluate Vasalgel™, a high molecular weight polymer being developed as a contraceptive device for men. METHODS: Sixteen adult male rhesus monkeys received intravas injections of Vasalgel, consisting of 25% styrene maleic acid in dimethyl sulfoxide. After a one-week recovery, males were returned to outdoor group housing, which included at least 3 and up to 9 intact, breeding females with a successful reproductive history...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28185437/crosslinked-network-with-rotatable-binding-sites-based-on-mono-carboxylated-%C3%AE-cyclodextrin-2-rotaxane-capable-of-angiotensin-iii-recognition
#2
Ko-Hei Ohmori, Tooru Ooya, Toshifumi Takeuchi
Synthetic receptors selective for target peptides or proteins have received attention because of their potential applications in the separation of biomolecules and biomedical diagnostics. In this study, a [2]rotaxane-based functional monomer containing mono-carboxylated α-cyclodextrin (α-CD) was synthesized, and its crosslinked polymers were evaluated to determine their binding ability to a model peptide, angiotensin III (Arg-Val-Tyr-Ile-His-Pro-Phe), containing an arginine (Arg) residue. The binding ability of the resulting polymers toward angiotensin III, angiotensin IV (Val-Tyr-Ile-His-Pro-Phe), and FMRF-amide (Phe-Met-Arg-Phe) was examined by the batch-binding assay and compared with that of control polymers in which maleic acid-introduced α-CD was chemically crosslinked...
February 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28183619/self-healing-ph-sensitive-poly-methyl-vinyl-ether-alt-maleic-acid-based-supramolecular-hydrogels-formed-by-inclusion-complexation-between-cyclodextrin-and-adamantane
#3
Xiaoe Ma, Naizhen Zhou, Tianzhu Zhang, Wanjun Hu, Ning Gu
Self-healing materials are of interest for drug delivery, cell and gene therapy, tissue engineering, and other biomedical applications. In this work, on the base of biocompatible polymer poly(methyl vinyl ether-alt-maleic acid) (P(MVE-alt-MA)), host polymer β-cyclodextrin-grafted P(MVE-alt-MA) (P(MVE-alt-MA)-g-β-CD) and guest polymer adamantane-grafted P(MVE-alt-MA) (P(MVE-alt-MA)-g-Ad) were first prepared. Then through taking advantage of the traditional host-guest interaction of β-cyclodextrin and adamantane, a novel self-healing pH-sensitive physical P(MVE-alt-MA)-g-β-CD/P(MVE-alt-MA)-g-Ad supramolecular hydrogels were obtained after simply mixing the aqueous solution of host polymer and guest polymer...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28170232/contaminant-removal-from-source-waters-using-cathodic-electrochemical-membrane-filtration-mechanisms-and-implications
#4
Junjian Zheng, Jinxing Ma, Zhiwei Wang, Shaoping Xu, T David Waite, Zhichao Wu
Removal of recalcitrant anthropogenic contaminants from water calls for the development of cost-effective treatment technologies. In this work, a novel electrochemical membrane filtration (EMF) process using a conducting microfiltration membrane as the cathode has been developed and the degradation of sulphanilic acid (SA) examined. The electrochemical degradation of SA in flow-by mode followed pseudo-first-order kinetics with the degradation rate enhanced with increase in charging voltage. Hydrogen peroxide as well as oxidants such as HO• and Fe(IV)O2+ were generated electrochemically with HO• found to be the dominant oxidant responsible for SA degradation...
February 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28164471/porous-zirconium-furandicarboxylate-microspheres-for-efficient-redox-conversion-of-biofuranics
#5
Hu Li, Xiaofang Liu, Tingting Yang, Wenfeng Zhao, Shunmugavel Saravanamurugan, Song Yang
Biofuranic compounds, typically derived from C5 and C6 carbohydrates, have been extensively studied as promising alternatives to fossil fule-based chemicals. The present work reports the simple assembly of bio-based 2,5-furandicarboxylic acid (FDCA) with different metal ions to prepare a range of metal-FDCA hybrids under hydrothermal conditions, which were demonstrated to have porous structure and acid-base bifunctionality. Especially, Zr-FDCA-T showed microspheric structure, high thermostability (ca. 400 ºC), ampliative average pore diameters (ca...
February 6, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28161252/synthesis-and-biological-evaluation-of-cyclic-imides-incorporating-benzenesulfonamide-moieties-as-carbonic-anhydrase-i-ii-iv-and-ix-inhibitors
#6
Alaa A-M Abdel-Aziz, Andrea Angeli, Adel S El-Azab, Mohamed A Abu El-Enin, Claudiu T Supuran
A group of cyclic imides was synthesized by reaction of amino-substituted benzenesulfonamides with a series of acid anhydrides such as succinic, maleic, tetrahydrophthalic, pyrazine-2,3-dicarboxylic acid anhydride, and substituted phthalic anhydrides. The synthesized sulfonamides were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors against the human (h) isoforms hCA I, II, IV and IX, involved in a variety of diseases among which glaucoma, retinitis pigmentosa, etc. Some of these sulfonamides showed effective inhibitory action (in the nanomolar range) against the cytosolic isoform hCA II and the transmembrane, tumor-associated one hCA IX, making them interesting candidates for preclinical evaluation in glaucoma or various tumors in which the two enzymes are involved...
January 24, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28159519/intracellular-responsive-dual-delivery-by-endosomolytic-polyplexes-carrying-dna-anchored-porous-silicon-nanoparticles
#7
Mohammad-Ali Shahbazi, Patrick Vingadas Almeida, Alexandra Correia, Barbara Herranz-Blanco, Neha Shrestha, Ermei Mäkilä, Jarno Salonen, Jouni Hirvonen, Hélder A Santos
Bioresponsive cytosolic nanobased multidelivery has been emerging as an enormously challenging novel concept due to the intrinsic protective barriers of the cells and hardly controllable performances of nanomaterials. Here, we present a new paradigm to advance nano-in-nano integration technology amenable to create multifunctional nanovehicles showing considerable promise to overcome restrictions of intracellular delivery, solve impediments of endosomal localization and aid effectual tracking of nanoparticles...
February 1, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28153250/fabrication-of-enzyme-reactor-utilizing-magnetic-porous-polymer-membrane-for-screening-d-amino-acid-oxidase-inhibitors
#8
Jun Fang Jiang, Juan Qiao, Xiao Yu Mu, Myeong Hee Moon, Li Qi
In this work, a unique D-amino acid oxidase reactor for enhanced enzymolysis efficiency is presented. A kind of magnetic polymer matrices, composed of iron oxide nanoparticles and porous polymer membrane (poly styrene-co-maleic anhydride), was prepared. With covalent bonding D-Amino acid oxidase on the surface of the matrices and characterization of scanning electron microscope and vibrating sample magnetometer, it demonstrated that the membrane enzyme reactor was successfully constructed. The enzymolysis efficiency of the enzyme reactor was evaluated and the apparent Michaelis-Menten constants of D-Amino acid oxidase were determined (Km was 1...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28144143/conductive-polymer-based-nanoparticles-for-laser-mediated-photothermal-ablation-of-cancer-synthesis-characterization-and-in-vitro-evaluation
#9
Travis Cantu, Kyle Walsh, Varun P Pattani, Austin J Moy, James W Tunnell, Jennifer A Irvin, Tania Betancourt
Laser-mediated photothermal ablation of cancer cells aided by photothermal agents is a promising strategy for localized, externally controlled cancer treatment. We report the synthesis, characterization, and in vitro evaluation of conductive polymeric nanoparticles (CPNPs) of poly(diethyl-4,4'-{[2,5-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-1,4-phenylene] bis(oxy)}dibutanoate) (P1) and poly(3,4-ethylenedioxythiophene) (PEDOT) stabilized with 4-dodecylbenzenesulfonic acid and poly(4-styrenesulfonic acid-co-maleic acid) as photothermal ablation agents...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28128538/proton-detected-solid-state-nmr-spectroscopy-of-a-zinc-diffusion-facilitator-protein-in-native-nanodiscs
#10
Beate Bersch, Jonas M Dörr, Audrey Hessel, J Antoinette Killian, Paul Schanda
The structure, dynamics, and function of membrane proteins are intimately linked to the properties of the membrane environment in which the proteins are embedded. For structural and biophysical characterization, membrane proteins generally need to be extracted from the membrane and reconstituted in a suitable membrane-mimicking environment. Ensuring functional and structural integrity in these environments is often a major concern. The styrene/maleic acid co-polymer has recently been shown to be able to extract lipid/membrane protein patches directly from native membranes to form nanosize discoidal proteolipid particles, also referred to as native nanodiscs...
February 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28125020/relationship-between-surface-properties-and-in-vitro-drug-release-from-compressed-matrix-containing-polymeric-materials-with-different-hydrophobicity-degrees
#11
Cristhian J Yarce, Juan D Echeverri, Mario A Palacio, Carlos A Rivera, Constain H Salamanca
This work is the continuation of a study focused on establishing relations between surface thermodynamic properties and in vitro release mechanisms using a model drug (ampicillin trihydrate), besides analyzing the granulometric properties of new polymeric materials and thus establishing the potential to be used in the pharmaceutical field as modified delivery excipients. To do this, we used copolymeric materials derived from maleic anhydride with decreasing polarity corresponding to poly(isobutylene-alt-maleic acid) (hydrophilic), sodium salt of poly(maleic acid-alt-octadecene) (amphiphilic), poly(maleic anhydride-alt-octadecene) (hydrophobic) and the reference polymer hydroxyl-propyl-methyl-cellulose (HPMC)...
January 24, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28121157/byproduct-free-route-to-aminosiloxane-monolayers-on-silicon-silicon-dioxide
#12
Kiran Khadka, Nicholas C Strandwitz, Gregory S Ferguson
The chemisorption of N-methyl-aza-2,2,4-trimethylsilacyclopentane from either the solution or the vapor phase produces monolayer films on silicon (oxide) substrates. The formation of a covalent siloxane linkage to the surface by this adsorbate is accompanied by ring opening, which produces no byproduct. The resulting secondary amine reacts with maleic anhydride to produce a carboxylic acid-terminated surface, accompanied by the formation of a stable amide bond. These reactions and their products were characterized by a combination of optical ellipsometry, contact-angle goniometry, and X-ray photoelectron spectroscopy...
February 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28098457/surface-forces-and-rheology-of-titanium-dioxide-in-the-presence-of-dicarboxylic-acids-from-molecular-interactions-to-yield-stress
#13
E-Jen Teh, Yee-Kwong Leong, Vincent S J Craig
The surface forces and yield stress of titanium dioxide were measured in the presence of dicarboxylic acids in order to understand the molecular basis for the observed rheological response. The yield stress was measured using the static vane technique, and the surface forces were characterized using an atomic force microscope. The trans and cis isomers of butenedioic acid (fumaric and maleic acids, respectively) were chosen as the relative orientation of the carboxylic groups differs substantially. This enables us to test the hypothesis that an increase in adhesion leads to an increase in yield stress as a consequence of the dicarboxylic acids participating in highly directed bridging...
January 31, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28097924/enhancing-the-performance-of-electro-peroxone-by-incorporation-of-uv-irradiation-and-bdd-anodes
#14
Nasr Bensalah, Ahmed Bedoui
In this work, the treatment of 4-nitrophenol (NP) in water by ozonation, electrolysis, electro-peroxone (EP), and photo-electro-peroxone (PEP) processes was investigated. PEP process is based on the combination of ozonation, UV irradiation, and electrolysis using carbon felt cathode and Boron Doped Diamond (BDD) anode. In this process, H2O2 is electrochemically generated from reduction of O2 in the ozone generator effluent at a carbon felt cathode. The insitu generated H2O2 is simultaneously decomposed by UV- photolysis and by reaction with O3 to form HO(-) radicals that can rapidly and non-selectively oxidize organic pollutants...
January 18, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28089451/crystallogenesis-of-membrane-proteins-mediated-by-polymer-bounded-lipid-nanodiscs
#15
Jana Broecker, Bryan T Eger, Oliver P Ernst
For some membrane proteins, detergent-mediated solubilization compromises protein stability and functionality, often impairing biophysical and structural analyses. Hence, membrane-protein structure determination is a continuing bottleneck in the field of protein crystallography. Here, as an alternative to approaches mediated by conventional detergents, we report the crystallogenesis of a recombinantly produced membrane protein that never left a lipid bilayer environment. We used styrene-maleic acid (SMA) copolymers to solubilize lipid-embedded proteins into SMA nanodiscs, purified these discs by affinity and size-exclusion chromatography, and transferred proteins into the lipidic cubic phase (LCP) for in meso crystallization...
February 7, 2017: Structure
https://www.readbyqxmd.com/read/28088118/histidine-functionalized-carbon-based-dot-zinc-ii-nanoparticles-as-a-novel-stabilizer-for-pickering-emulsion-synthesis-of-polystyrene-microspheres
#16
Li Ruiyi, Li Zaijun, Liu Junkang
Carbon-based dots (CDs) are nanoparticles with size-dependent optical and electronic properties that have been widely applied in energy-efficient displays and lighting, photovoltaic devices and biological markers. However, conventional CDs are difficult to be used as ideal stabilizer for Pickering emulsion due to its irrational amphiphilic structure. The study designed and synthesized a new histidine-functionalized carbon dot-Zinc(II) nanoparticles, which is termed as His-CD-Zn. The His-CD was made via one-step hydrothermal treatment of histidine and maleic acid...
January 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28079955/solubilization-of-membrane-proteins-into-functional-lipid-bilayer-nanodiscs-using-a-diisobutylene-maleic-acid-copolymer
#17
Abraham Olusegun Oluwole, Bartholomäus Danielczak, Annette Meister, Jonathan Oyebamiji Babalola, Carolyn Vargas, Sandro Keller
Once removed from their natural environment, membrane proteins depend on membrane-mimetic systems to retain their native structures and functions. To this end, lipid-bilayer nanodiscs that are bounded by scaffold proteins or amphiphilic polymers such as styrene/maleic acid (SMA) copolymers have been introduced as alternatives to detergent micelles and liposomes for in vitro membrane-protein research. Herein, we show that an alternating diisobutylene/maleic acid (DIBMA) copolymer shows equal performance to SMA in solubilizing phospholipids, stabilizes an integral membrane enzyme in functional bilayer nanodiscs, and extracts proteins of various sizes directly from cellular membranes...
February 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28078651/fed-batch-enzymatic-saccharification-of-high-solids-pretreated-lignocellulose-for-obtaining-high-titers-and-high-yields-of-glucose
#18
Young Hoon Jung, Hyun Min Park, Dong Hyun Kim, Jungwoo Yang, Kyoung Heon Kim
To reduce the distillation costs of cellulosic ethanol, it is necessary to produce high sugar titers in the enzymatic saccharification step. To obtain high sugar titers, high biomass loadings of lignocellulose are necessary. In this study, to overcome the low saccharification yields and the low operability of high biomass loadings, a fed-batch saccharification process was developed using an enzyme reactor that was designed and built in-house. After optimizing the cellulase and biomass feeding profiles and the agitation speed, 132...
January 11, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28064122/correlation-between-degradation-pathway-and-toxicity-of-acetaminophen-and-its-by-products-by-using-the-electro-fenton-process-in-aqueous-media
#19
Thi Xuan Huong Le, Thi Van Nguyen, Zoulkifli Amadou Yacouba, Laetitia Zoungrana, Florent Avril, Duy Linh Nguyen, Eddy Petit, Julie Mendret, Valerie Bonniol, Mikhael Bechelany, Stella Lacour, Geoffroy Lesage, Marc Cretin
The evolution of the degradation by-products of an acetaminophen (ACE) solution was monitored by HPLC-UV/MS and IC in parallel with its ecotoxicity (Vibrio fischeri 81.9%, Microtox(®) screening tests) during electro-Fenton (EF) oxidation performed on carbon felt. The aromatic compounds 2-hydroxy-4-(N-acetyl) aminophenol, 1,4-benzoquinone, benzaldehyde and benzoic acid were identified as toxic sub-products during the first stage of the electrochemical treatment, whereas aliphatic short-chain carboxylic acids (oxalic, maleic, oxamic, formic, acetic and fumaric acids) and inorganic ions (ammonium and nitrate) were well identified as non-toxic terminal sub-products...
April 2017: Chemosphere
https://www.readbyqxmd.com/read/28035097/new-1-1-and-2-1-salts-in-the-dl-norvaline-maleic-acid-system-as-an-example-of-assembling-various-crystal-structures-from-similar-supramolecular-building-blocks
#20
Sergey G Arkhipov, Evgeniy A Losev, Elena V Boldyreva
Molecular salts and cocrystals of amino acids have potential applications as molecular materials with nonlinear optical, ferroelectric, piezoelectric, and other various target physical properties. The wide choice of amino acids and coformers makes it possible to design various crystal structures. The amino acid-maleic acid system provides a perfect example of a rich variety of crystal structures with different stoichiometries, symmetries and packing motifs built from the molecular building blocks, which are either exactly the same, or differ merely by protonation or as optical isomers...
January 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
keyword
keyword
77639
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"