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Maleic acid

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https://www.readbyqxmd.com/read/28340956/stability-orders-of-acetaminophen-and-theophylline-co-crystals-determined-by-co-crystal-former-exchange-reactions-and-their-correlation-with-in-silico-and-thermal-parameters
#1
Makoto Mukaida, Haruna Sato, Kiyohiko Sugano, Katsuhide Terada
The aim of this study was to determine the thermodynamic stability order of co-crystals using co-crystal former exchange reactions and to validate 2 in silico parameters for predicting co-crystal formation. Co-crystal former exchange reactions were performed using acetaminophen (AC) co-crystals of oxalic acid (OX), maleic acid (MA), and theophylline (TH). The addition of TH to an AC-MA co-crystal (AC-MA) afforded AC-TH, suggesting that AC-TH was more stable than AC-MA. The stability order among the other co-crystals was determined in the same manner...
January 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28340950/pharmacokinetics-and-bioavailability-of-oral-single-dose-maleic-acid-in-biofluids-of-sprague-dawley-rats
#2
Charlene Wu, Hsin-Chang Chen, Yu-Syuan Luo, Su-Yin Chiang, Kuen-Yuh Wu
Maleic acid (MA) was purposefully adulterated in an array of starch-based foods in Taiwan, inciting a food safety incident. Due to limited data on the pharmacokinetics and bioavailability of ingested MA, we studied pharmacokinetic (PK) parameters in serum and urine of Sprague Dawley rats. Three groups of male and female rats were given three doses of MA by oral gavage; biofluid samples were collected accordingly. Data demonstrated that a non-compartment model best described MA's linear kinetic behavior upon ingestion...
December 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28331124/evaluation-of-adsorption-characteristics-of-a-fibrous-adsorbent-containing-zwitter-ionic-functional-group-targeting-organic-acids
#3
Akira Nakazawa, Ning Tang, Yoshinori Inoue, Waka Kamichatani, Toshifumi Katoh, Mitsuru Saito, Kenji Obara, Akira Toriba, Kazuichi Hayakawa
Diallylamine-maleic acid copolymer (DAM)-nonwoven fabric (DAM-f), a fibrous adsorbent, contains DAM with zwitter-ionic functional groups and forms a hydration layer on the surface. The aim of this report was to evaluate the adsorption selectivity of DAM-f to semi-volatile organic acid (C1-C5). In the aqueous phase, formic acid dissolved in the hydration layer bound to the imino group of DAM-f due to anion exchange interaction. In the gas phase, the adsorption amounts of organic acids increased with the exposure time...
2017: Journal of UOEH
https://www.readbyqxmd.com/read/28325345/novel-modified-nanocellulose-applicable-as-reinforcement-in-high-performance-nanocomposites
#4
Jelena D Rusmirović, Jasna Z Ivanović, Vladimir B Pavlović, Vesna M Rakić, Milica P Rančić, Veljko Djokić, Aleksandar D Marinković
The influence of modification and vacuum/supercritical CO2 (scCO2) drying methods on the surface properties, morphology and thermal stability of cellulose nanocrystals (NC) was presented in this study. Introduction of reactive vinyl groups on NC surface was performed by either direct esterification with oleic acid, linseed or sunflower oil fatty acids; or by amidation of maleic acid/ethylene diamine with methyl ester of fatty acid. Obtained modified NC (m-NC) were characterized using FTIR and Raman spectroscopy; and by determination of acid, iodine and ester values...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28322950/pectin-blended-anionic-polysaccharide-films-for-cationic-contaminant-sorption-from-water
#5
Mei Li, Gisela Buschle-Diller
Substantial amounts of industrial, agricultural, medical and domestic water worldwide are polluted by different types of contaminants. Removing these contaminants from effluent by adsorbent materials made from abundant, inexpensive polysaccharides is a feasible and promising approach to deal with this problem. In the present study, pectin blended with four other types of anionic polysaccharides, including alginate, carrageenan, xylan and xanthan, were crosslinked with zinc acetate and formed into thin films...
March 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28282572/performance-of-nitrogen-doped-graphene-aerogel-particle-electrodes-for-electro-catalytic-oxidation-of-simulated-bisphenol-a-wastewaters
#6
Zhuang Chen, Yimei Zhang, Lincheng Zhou, Hao Zhu, Fei Wan, Yue Wang, Dandan Zhang
The treatment of effluent containing Bisphenol A (BPA) was investigated experimentally using nitrogen-doped graphene aerogel (NGAs) as particle electrodes in a three-dimensional electrode reactor for the electrochemical treatment was studied. The effects of the cell voltage, pH, the ratio of NGAs mass to solution volume and repeated times on the removal efficiency were investigated. Compared with commercial carbon particle electrodes, the NGAs exhibited stronger activity to remove BPA simulated wastewater. For 15mgL(-1) of BPA solution, the degradation rate of BPA exceeded 90% after treatment for only 30min under the optimum conditions...
February 27, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28274438/detection-of-unexpected-frauds-screening-and-quantification-of-maleic-acid-in-cassava-starch-by-fourier-transform-near-infrared-spectroscopy
#7
Hai-Yan Fu, He-Dong Li, Lu Xu, Qiao-Bo Yin, Tian-Ming Yang, Chuang Ni, Chen-Bo Cai, Ji Yang, Yuan-Bin She
Fourier transform near-infrared (FT-NIR) spectroscopy and chemometrics were adopted for the rapid analysis of a toxic additive, maleic acid (MA), which has emerged as a new extraneous adulterant in cassava starch (CS). After developing an untargeted screening method for MA detection in CS using one-class partial least squares (OCPLS), multivariate calibration models were subsequently developed using least squares support vector machine (LS-SVM) to quantitatively analyze MA. As a result, the OCPLS model using the second-order derivative (D2) spectra detected 0...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28254415/functional-reconstitution-of-human-equilibrative-nucleoside-transporter-1-into-styrene-maleic-acid-co-polymer-lipid-particles
#8
Shahid Rehan, Ville O Paavilainen, Veli-Pekka Jaakola
The human equilibrative nucleoside transporter-1 (hENT1) is important for the entry of anti-cancer and anti-viral nucleoside analog therapeutics into the cell, and thus for their efficacy. Understanding of hENT1 structure-function relationship could assist with development of nucleoside analogs with better cellular uptake properties. However, structural and biophysical studies of hENT1 remain challenging as the hydrophobic nature of the protein leads to complete aggregation upon detergent-based membrane isolation...
February 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28252159/amine-selective-affinity-resins-based-on-ph-sensitive-reversible-formation-of-covalent-bonds
#9
Youngjun Song, Dongwook Jung, Sunyoung Kang, Yan Lee
A new class of affinity resins using reversible covalent bonds is introduced for the separation of amine-containing molecules. pH-sensitive reversible formation of amic acid bonds between amines and carboxylate dimethyl maleic anhydride-decorated wrinkled silica nanoparticle resins was used to selectively retain and release amine-containing molecules, by controlling the pH.
March 2, 2017: Soft Matter
https://www.readbyqxmd.com/read/28245127/continuous-preparation-of-1-1-haloperidol-maleic-acid-salt-by-novel-solvent-free-method-using-twin-screw-melt-extruder
#10
Hung Lin Lee, Jaydip M Vasoya, Marilia de Lima Cirqueira, Kuan Lin Yeh, Tu Lee, Abu T M Serajuddin
Salts are generally prepared by acid-base reaction in relatively large volumes of organic solvents and then followed by crystallization. In this study, the potential for preparing pharmaceutical salt between haloperidol and maleic acid by a novel solvent-free method using twin-screw melt extruder was investigated. The pH-solubility relationship between haloperidol and maleic acid in aqueous medium was first determined, which demonstrated that 1:1 salt formation between them was feasible (pHmax 4.8; salt solubility 4...
February 28, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28191316/the-contraceptive-efficacy-of-intravas-injection-of-vasalgel%C3%A2-for-adult-male-rhesus-monkeys
#11
Angela Colagross-Schouten, Marie-Josee Lemoy, Rebekah I Keesler, Elaine Lissner, Catherine A VandeVoort
BACKGROUND: Options for male contraception are limited. The purpose of this study was to use a nonhuman primate model to evaluate Vasalgel™, a high molecular weight polymer being developed as a contraceptive device for men. METHODS: Sixteen adult male rhesus monkeys received intravas injections of Vasalgel, consisting of 25% styrene maleic acid in dimethyl sulfoxide. After a one-week recovery, males were returned to outdoor group housing, which included at least 3 and up to 9 intact, breeding females with a successful reproductive history...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28185437/crosslinked-network-with-rotatable-binding-sites-based-on-mono-carboxylated-%C3%AE-cyclodextrin-2-rotaxane-capable-of-angiotensin-iii-recognition
#12
Ko-Hei Ohmori, Tooru Ooya, Toshifumi Takeuchi
Synthetic receptors selective for target peptides or proteins have received attention because of their potential applications in the separation of biomolecules and biomedical diagnostics. In this study, a [2]rotaxane-based functional monomer containing mono-carboxylated α-cyclodextrin (α-CD) was synthesized, and its crosslinked polymers were evaluated to determine their binding ability to a model peptide, angiotensin III (Arg-Val-Tyr-Ile-His-Pro-Phe), containing an arginine (Arg) residue. The binding ability of the resulting polymers toward angiotensin III, angiotensin IV (Val-Tyr-Ile-His-Pro-Phe), and FMRF-amide (Phe-Met-Arg-Phe) was examined by the batch-binding assay and compared with that of control polymers in which maleic acid-introduced α-CD was chemically crosslinked...
February 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28183619/self-healing-ph-sensitive-poly-methyl-vinyl-ether-alt-maleic-acid-based-supramolecular-hydrogels-formed-by-inclusion-complexation-between-cyclodextrin-and-adamantane
#13
Xiaoe Ma, Naizhen Zhou, Tianzhu Zhang, Wanjun Hu, Ning Gu
Self-healing materials are of interest for drug delivery, cell and gene therapy, tissue engineering, and other biomedical applications. In this work, on the base of biocompatible polymer poly(methyl vinyl ether-alt-maleic acid) (P(MVE-alt-MA)), host polymer β-cyclodextrin-grafted P(MVE-alt-MA) (P(MVE-alt-MA)-g-β-CD) and guest polymer adamantane-grafted P(MVE-alt-MA) (P(MVE-alt-MA)-g-Ad) were first prepared. Then through taking advantage of the traditional host-guest interaction of β-cyclodextrin and adamantane, a novel self-healing pH-sensitive physical P(MVE-alt-MA)-g-β-CD/P(MVE-alt-MA)-g-Ad supramolecular hydrogels were obtained after simply mixing the aqueous solution of host polymer and guest polymer...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28170232/contaminant-removal-from-source-waters-using-cathodic-electrochemical-membrane-filtration-mechanisms-and-implications
#14
Junjian Zheng, Jinxing Ma, Zhiwei Wang, Shaoping Xu, T David Waite, Zhichao Wu
Removal of recalcitrant anthropogenic contaminants from water calls for the development of cost-effective treatment technologies. In this work, a novel electrochemical membrane filtration (EMF) process using a conducting microfiltration membrane as the cathode has been developed and the degradation of sulphanilic acid (SA) examined. The electrochemical degradation of SA in flow-by mode followed pseudo-first-order kinetics with the degradation rate enhanced with increase in charging voltage. Hydrogen peroxide as well as oxidants such as HO(•) and Fe(IV)O(2+) were generated electrochemically with HO(•) found to be the dominant oxidant responsible for SA degradation...
February 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28164471/porous-zirconium-furandicarboxylate-microspheres-for-efficient-redox-conversion-of-biofuranics
#15
Hu Li, Xiaofang Liu, Tingting Yang, Wenfeng Zhao, Shunmugavel Saravanamurugan, Song Yang
Biofuranic compounds, typically derived from C5 and C6 carbohydrates, have been extensively studied as promising alternatives to fossil fule-based chemicals. The present work reports the simple assembly of bio-based 2,5-furandicarboxylic acid (FDCA) with different metal ions to prepare a range of metal-FDCA hybrids under hydrothermal conditions, which were demonstrated to have porous structure and acid-base bifunctionality. Especially, Zr-FDCA-T showed microspheric structure, high thermostability (ca. 400 ºC), ampliative average pore diameters (ca...
February 6, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28161252/synthesis-and-biological-evaluation-of-cyclic-imides-incorporating-benzenesulfonamide-moieties-as-carbonic-anhydrase-i-ii-iv-and-ix-inhibitors
#16
Alaa A-M Abdel-Aziz, Andrea Angeli, Adel S El-Azab, Mohamed A Abu El-Enin, Claudiu T Supuran
A group of cyclic imides was synthesized by reaction of amino-substituted benzenesulfonamides with a series of acid anhydrides such as succinic, maleic, tetrahydrophthalic, pyrazine-2,3-dicarboxylic acid anhydride, and substituted phthalic anhydrides. The synthesized sulfonamides were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors against the human (h) isoforms hCA I, II, IV and IX, involved in a variety of diseases among which glaucoma, retinitis pigmentosa, etc. Some of these sulfonamides showed effective inhibitory action (in the nanomolar range) against the cytosolic isoform hCA II and the transmembrane, tumor-associated one hCA IX, making them interesting candidates for preclinical evaluation in glaucoma or various tumors in which the two enzymes are involved...
March 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28159519/intracellular-responsive-dual-delivery-by-endosomolytic-polyplexes-carrying-dna-anchored-porous-silicon-nanoparticles
#17
Mohammad-Ali Shahbazi, Patrick Vingadas Almeida, Alexandra Correia, Barbara Herranz-Blanco, Neha Shrestha, Ermei Mäkilä, Jarno Salonen, Jouni Hirvonen, Hélder A Santos
Bioresponsive cytosolic nanobased multidelivery has been emerging as an enormously challenging novel concept due to the intrinsic protective barriers of the cells and hardly controllable performances of nanomaterials. Here, we present a new paradigm to advance nano-in-nano integration technology amenable to create multifunctional nanovehicles showing considerable promise to overcome restrictions of intracellular delivery, solve impediments of endosomal localization and aid effectual tracking of nanoparticles...
February 1, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28153250/fabrication-of-enzyme-reactor-utilizing-magnetic-porous-polymer-membrane-for-screening-d-amino-acid-oxidase-inhibitors
#18
Jun Fang Jiang, Juan Qiao, Xiao Yu Mu, Myeong Hee Moon, Li Qi
In this work, a unique D-amino acid oxidase reactor for enhanced enzymolysis efficiency is presented. A kind of magnetic polymer matrices, composed of iron oxide nanoparticles and porous polymer membrane (poly styrene-co-maleic anhydride), was prepared. With covalent bonding D-Amino acid oxidase on the surface of the matrices and characterization of scanning electron microscope and vibrating sample magnetometer, it demonstrated that the membrane enzyme reactor was successfully constructed. The enzymolysis efficiency of the enzyme reactor was evaluated and the apparent Michaelis-Menten constants of D-Amino acid oxidase were determined (Km was 1...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28144143/conductive-polymer-based-nanoparticles-for-laser-mediated-photothermal-ablation-of-cancer-synthesis-characterization-and-in-vitro-evaluation
#19
Travis Cantu, Kyle Walsh, Varun P Pattani, Austin J Moy, James W Tunnell, Jennifer A Irvin, Tania Betancourt
Laser-mediated photothermal ablation of cancer cells aided by photothermal agents is a promising strategy for localized, externally controlled cancer treatment. We report the synthesis, characterization, and in vitro evaluation of conductive polymeric nanoparticles (CPNPs) of poly(diethyl-4,4'-{[2,5-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-1,4-phenylene] bis(oxy)}dibutanoate) (P1) and poly(3,4-ethylenedioxythiophene) (PEDOT) stabilized with 4-dodecylbenzenesulfonic acid and poly(4-styrenesulfonic acid-co-maleic acid) as photothermal ablation agents...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28128538/proton-detected-solid-state-nmr-spectroscopy-of-a-zinc-diffusion-facilitator-protein-in-native-nanodiscs
#20
Beate Bersch, Jonas M Dörr, Audrey Hessel, J Antoinette Killian, Paul Schanda
The structure, dynamics, and function of membrane proteins are intimately linked to the properties of the membrane environment in which the proteins are embedded. For structural and biophysical characterization, membrane proteins generally need to be extracted from the membrane and reconstituted in a suitable membrane-mimicking environment. Ensuring functional and structural integrity in these environments is often a major concern. The styrene/maleic acid co-polymer has recently been shown to be able to extract lipid/membrane protein patches directly from native membranes to form nanosize discoidal proteolipid particles, also referred to as native nanodiscs...
February 20, 2017: Angewandte Chemie
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