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Maleic acid

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https://www.readbyqxmd.com/read/28438549/poly-methyl-vinyl-ether-co-maleic-acid-pectin-based-hydrogel-forming-systems-gel-film-and-microneedles
#1
Yusuf Kemal Demir, Ayşegül Ülkü Metin, Betül Şatıroğlu, Mehmet Ertuğrul Solmaz, Veysel Kayser, Karsten Mäder
Cross-linking of natural and synthetic polymers is widely explored to achieve the desired material properties (mechanical strength, drug loading capacity, swelling and erosion rates). However, the potential of polymers produced by crosslinking poly (methyl vinyl ether-co-maleic acid) (PMVE/MA) and pectin (PE) in pharmaceutics is mainly unexplored so far. We have investigated the effect of various esterification conditions and pectin content on the physicochemical properties. Materials have been characterized by fourier transform infrared, differential scanning calorimetry and scanning electron microscopy...
April 21, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28435710/inter-action-between-maleic-acid-and-n-r-furfuryl-amines-crystal-structure-of-2-methyl-n-5-phenyl-furan-2-yl-meth-yl-propan-2-aminium-2z-3-carb-oxy-acrylate-and-n-5-iodo-furan-2-yl-meth-yl-2-methyl-propan-2-aminium-2z-3-carb-oxy-prop-2-enoate
#2
Elisaveta A Kvyatkovskaya, Vladimir P Zaytsev, Fedor I Zubkov, Pavel V Dorovatovskii, Yan V Zubavichus, Victor N Khrustalev
The title mol-ecular salts, C15H20NO(+)·C4H3O4(-), (I), and C9H15INO(+)·C4H3O4(-), (II), have very similar mol-ecular geometries for both cation and anion. The anions of both (I) and (II) are practically planar (r.m.s. deviations = 0.062 and 0.072 Å, respectively) and adopt a rare symmetrical geometry with the hy-droxy H atom approximately equidistant from the two O atoms. In their crystals, the cations and anions in both (I) and (II) form tight ionic pairs via strong N-H⋯O hydrogen bonds, with a roughly perpendicular disposition of the anion to the furan ring of the cation...
April 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28433941/self-assembled-dual-responsive-micelles-stabilized-with-protein-for-co-delivery-of-drug-and-sirna-in-cancer-therapy
#3
M R Aji Alex, Chetan Nehate, Srivani Veeranarayanan, D Sakthi Kumar, Ritu Kulshreshtha, Veena Koul
Design of safe and efficient vehicles for the combinatorial delivery of drugs and genetic agents is an emerging requisite for achieving enhanced therapeutic effect in cancer. Even though several nanoplatforms have been explored for the co-delivery of drugs and genetic materials the translation of these systems to clinical phase is still a challenge, mainly due to tedious synthesis procedures, lack of serum stability, inefficient scalability etc. Here in, we report development of reduction and pH sensitive polymeric graft of low molecular weight poly (styrene -alt -maleic anhydride) and evaluation of its efficacy in co-delivering drug and siRNA...
April 17, 2017: Biomaterials
https://www.readbyqxmd.com/read/28433151/integrated-production-of-lignin-containing-cellulose-nanocrystals-lcnc-and-nanofibrils-lcnf-using-an-easily-recyclable-di-carboxylic-acid
#4
Huiyang Bian, Liheng Chen, Hongqi Dai, J Y Zhu
Here we demonstrate di-carboxylic acid hydrolysis for the integrated production of lignin containing cellulose nanocrystals (LCNC) and nanofibrils (LCNF) using two unbleached mixed hardwood chemical pulps of lignin contents of 3.9 and 17.2%. Acid hydrolysis experiments used maleic acid solution of 60wt% concentration at 120°C for 120min under ambient pressure. Yields of LCNC were low of less than 6% under this set of conditions. The higher lignin content sample produced LCNC with greater height (diameter) of 25nm but similar length of approximately 230nm to that from the lower lignin content fibers (height of 20nm)...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28420213/folate-decorated-nanomicelles-loaded-with-a-potent-curcumin-analogue-for-targeting-retinoblastoma
#5
Hashem Alsaab, Rami M Alzhrani, Prashant Kesharwani, Samaresh Sau, Sai Hs Boddu, Arun K Iyer
The aim of this study was to develop a novel folate receptor-targeted drug delivery system for retinoblastoma cells using a promising anticancer agent, curcumin-difluorinated (CDF), loaded in polymeric micelles. Folic acid was used as a targeting moiety to enhance the targeting and bioavailability of CDF. For this purpose, amphiphilic poly(styrene-co-maleic acid)-conjugated-folic acid (SMA-FA) was synthesized and utilized to improve the aqueous solubility of a highly hydrophobic, but very potent anticancer compound, CDF, and its targeted delivery to folate overexpressing cancers...
April 18, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28417005/reversibility-of-vasalgel%C3%A2-male-contraceptive-in-a-rabbit-model
#6
Donald Waller, David Bolick, Elaine Lissner, Christopher Premanandan, Gary Gamerman
BACKGROUND: Development of a non-hormonal long-acting reversible contraceptive for men could have a significant impact on reducing unintended pregnancies. Vasalgel™ is a high molecular weight polymer consisting of styrene-alt-maleic acid (SMA) dissolved in dimethyl sulfoxide being developed as a reversible male contraceptive device. It forms a hydrogel when implanted into the vasa deferentia, which prevents the passage of sperm. Previous studies in the rabbit have proven its efficacy, durability and rapid onset...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28414203/self-assembled-nanocomplex-between-polymerized-phenylboronic-acid-and-doxorubicin-for-efficient-tumor-targeted-chemotherapy
#7
Junseok Lee, Jinhwan Kim, Yeong Mi Lee, Dongsik Park, Sooseok Im, Eun Ho Song, Hansoo Park, Won Jong Kim
Since the discovery that nano-scaled particulates can easily be incorporated into tumors via the enhanced permeability and retention (EPR) effect, such nanostructures have been exploited as therapeutic small molecule delivery systems. However, the convoluted synthetic process of conventional nanostructures has impeded their feasibility and reproducibility in clinical applications. Herein, we report an easily prepared formulation of self-assembled nanostructures for systemic delivery of the anti-cancer drug doxorubicin (DOX)...
April 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28410801/layer-by-layer-self-assembly-of-polyelectrolyte-multilayers-on-silica-spheres-as-reversed-phase-hydrophilic-interaction-mixed-mode-stationary-phases-for-high-performance-liquid-chromatography
#8
Wenjie Zhao, Xiuming Jiang, Shujiao Ni, Yun Guo, Lijun He, Guoqiang Xiang, Shusheng Zhang
In this study, a series of stationary phases, comprising silica spheres and polyelectrolyte multilayers (PEMs) as the core and surface coating, respectively, were prepared via a layer-by-layer self-assembly approach for use in high-performance liquid chromatography. PEMs coatings were formed by the alternate deposition of positively charged poly(allylamine hydrochloride) and negatively charged poly(ethylene-alt-maleate) anions which were synthesized by esterification between poly(ethylene-alt-maleic anhydride) and n-alkyl alcohols (CnH2n+1OH, n=4, 8, 10, 12)...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28394572/oxidation-of-substituted-catechols-at-the-air-water-interface-production-of-carboxylic-acids-quinones-and-polyphenols
#9
Elizabeth A Pillar, Marcelo I Guzman
Anthropogenic activities contribute benzene, toluene, and anisole to the environment, which in the atmosphere are converted into the respective phenols, cresols, and methoxyphenols by fast gas-phase reaction with hydroxyl radicals (HO(•)). Further processing of the latter species by HO(•) decreases their vapor pressure as a second hydroxyl group is incorporated to accelerate their oxidative aging at interfaces and in aqueous particles. This work shows how catechol, pyrogallol, 3-methylcatechol, 4-methylcatechol, and 3-methoxycatechol (all proxies for oxygenated aromatics derived from benzene, toluene, and anisole) react at the air-water interface with increasing O3(g) during τc ≈ 1 μs contact time and contrasts their potential for electron transfer and in situ production of HO(•) using structure-activity relationships...
April 24, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28392987/profiling-transcriptomes-of-human-sh-sy5y-neuroblastoma-cells-exposed-to-maleic-acid
#10
Chia-Chi Wang, Yin-Chi Lin, Yin-Hua Cheng, Chun-Wei Tung
BACKGROUND: Maleic acid is a multi-functional chemical widely used in the field of industrial chemistry for producing food additives and food contact materials. As maleic acid may contaminate food by the release from food packages or intentional addition, it raises the concern about the effects of excessive dietary exposure to maleic acid on human health. However, the influence of maleic acid on human health has not been thoroughly studied. In silico toxicogenomics approaches have found the association between maleic acid and nervous system disease in human...
2017: PeerJ
https://www.readbyqxmd.com/read/28392495/cocrystal-solubility-product-analysis-dual-concentration-ph-mass-action-model-not-dependent-on-explicit-solubility-equations
#11
Alex Avdeef
A novel general computational approach is described to address many aspects of cocrystal (CC) solubility product (Ksp) determination of drug substances. The CC analysis program, pDISOL-X, was developed and validated with published model systems of various acid-base combinations of active pharmaceutical ingredients (APIs) and coformers: (i) carbamazepine cocrystal systems with 4-aminobenzoic acid, cinnamic acid, saccharin, and salicylic acid, (ii) for indomethacin with saccharin, (iii) for nevirapine with maleic acid, saccharin, and salicylic acid, and (iv) for gabapentin with 3-hydroxybenzoic acid...
April 6, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28384213/prevention-of-tgf-%C3%AE-induced-early-liver-fibrosis-by-a-maleic-acid-derivative-anti-oxidant-through-suppression-of-ros-inflammation-and-hepatic-stellate-cells-activation
#12
Kun-Lin Yang, Wen-Teng Chang, Ming-Yuan Hong, Kuo-Chen Hung, Chia-Chang Chuang
Current anti-fibrotic effect of antioxidants in vivo is disappointing due probably to the fact that once liver fibrogenesis is established it is too advanced to be reversed by anti-oxidation mechanism. We consider antioxidant may only act on the early phase of fibrogenesis. Thus, we had previously established an early liver fibrosis animal model using an inducible expression vector (pPK9a), which contains TGF-β gene and was hydro-dynamically transferred into mice to induce a transient liver fibrosis. TGF-β1 has been well documented to up-regulate the expression of α2(1) collagen (Col 1A2) gene in the liver via the reactive oxygen species (ROS); the process triggers inflammation, leading to hepatic stellate cells (HSC) activation and liver fibrogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28378790/fast-collisional-lipid-transfer-among-polymer-bounded-nanodiscs
#13
Rodrigo Cuevas Arenas, Bartholomäus Danielczak, Anne Martel, Lionel Porcar, Cécile Breyton, Christine Ebel, Sandro Keller
Some styrene/maleic acid (SMA) copolymers solubilise membrane lipids and proteins to form polymer-bounded nanodiscs termed SMA/lipid particles (SMALPs). Although SMALPs preserve a lipid-bilayer core, they appear to be more dynamic than other membrane mimics. We used time-resolved Förster resonance energy transfer and small-angle neutron scattering to determine the kinetics and the mechanisms of phospholipid transfer among SMALPs. In contrast with vesicles or protein-bounded nanodiscs, SMALPs exchange lipids not only by monomer diffusion but also by fast collisional transfer...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28340956/stability-orders-of-acetaminophen-and-theophylline-co-crystals-determined-by-co-crystal-former-exchange-reactions-and-their-correlation-with-in-silico-and-thermal-parameters
#14
Makoto Mukaida, Haruna Sato, Kiyohiko Sugano, Katsuhide Terada
The aim of this study was to determine the thermodynamic stability order of co-crystals using co-crystal former exchange reactions and to validate 2 in silico parameters for predicting co-crystal formation. Co-crystal former exchange reactions were performed using acetaminophen (AC) co-crystals of oxalic acid (OX), maleic acid (MA), and theophylline (TH). The addition of TH to an AC-MA co-crystal (AC-MA) afforded AC-TH, suggesting that AC-TH was more stable than AC-MA. The stability order among the other co-crystals was determined in the same manner...
January 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28340950/pharmacokinetics-and-bioavailability-of-oral-single-dose-maleic-acid-in-biofluids-of-sprague-dawley-rats
#15
Charlene Wu, Hsin-Chang Chen, Yu-Syuan Luo, Su-Yin Chiang, Kuen-Yuh Wu
Maleic acid (MA) was purposefully adulterated in an array of starch-based foods in Taiwan, inciting a food safety incident. Due to limited data on the pharmacokinetics and bioavailability of ingested MA, we studied pharmacokinetic (PK) parameters in serum and urine of Sprague Dawley rats. Three groups of male and female rats were given three doses of MA by oral gavage; biofluid samples were collected accordingly. Data demonstrated that a non-compartment model best described MA's linear kinetic behavior upon ingestion...
December 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28331124/evaluation-of-adsorption-characteristics-of-a-fibrous-adsorbent-containing-zwitter-ionic-functional-group-targeting-organic-acids
#16
Akira Nakazawa, Ning Tang, Yoshinori Inoue, Waka Kamichatani, Toshifumi Katoh, Mitsuru Saito, Kenji Obara, Akira Toriba, Kazuichi Hayakawa
Diallylamine-maleic acid copolymer (DAM)-nonwoven fabric (DAM-f), a fibrous adsorbent, contains DAM with zwitter-ionic functional groups and forms a hydration layer on the surface. The aim of this report was to evaluate the adsorption selectivity of DAM-f to semi-volatile organic acid (C1-C5). In the aqueous phase, formic acid dissolved in the hydration layer bound to the imino group of DAM-f due to anion exchange interaction. In the gas phase, the adsorption amounts of organic acids increased with the exposure time...
2017: Journal of UOEH
https://www.readbyqxmd.com/read/28325345/novel-modified-nanocellulose-applicable-as-reinforcement-in-high-performance-nanocomposites
#17
Jelena D Rusmirović, Jasna Z Ivanović, Vladimir B Pavlović, Vesna M Rakić, Milica P Rančić, Veljko Djokić, Aleksandar D Marinković
The influence of modification and vacuum/supercritical CO2 (scCO2) drying methods on the surface properties, morphology and thermal stability of cellulose nanocrystals (NC) was presented in this study. Introduction of reactive vinyl groups on NC surface was performed by either direct esterification with oleic acid, linseed or sunflower oil fatty acids; or by amidation of maleic acid/ethylene diamine with methyl ester of fatty acid. Obtained modified NC (m-NC) were characterized using FTIR and Raman spectroscopy; and by determination of acid, iodine and ester values...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28322950/pectin-blended-anionic-polysaccharide-films-for-cationic-contaminant-sorption-from-water
#18
Mei Li, Gisela Buschle-Diller
Substantial amounts of industrial, agricultural, medical and domestic water worldwide are polluted by different types of contaminants. Removing these contaminants from effluent by adsorbent materials made from abundant, inexpensive polysaccharides is a feasible and promising approach to deal with this problem. In the present study, pectin blended with four other types of anionic polysaccharides, including alginate, carrageenan, xylan and xanthan, were crosslinked with zinc acetate and formed into thin films...
March 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28282572/performance-of-nitrogen-doped-graphene-aerogel-particle-electrodes-for-electro-catalytic-oxidation-of-simulated-bisphenol-a-wastewaters
#19
Zhuang Chen, Yimei Zhang, Lincheng Zhou, Hao Zhu, Fei Wan, Yue Wang, Dandan Zhang
The treatment of effluent containing Bisphenol A (BPA) was investigated experimentally using nitrogen-doped graphene aerogel (NGAs) as particle electrodes in a three-dimensional electrode reactor for the electrochemical treatment was studied. The effects of the cell voltage, pH, the ratio of NGAs mass to solution volume and repeated times on the removal efficiency were investigated. Compared with commercial carbon particle electrodes, the NGAs exhibited stronger activity to remove BPA simulated wastewater. For 15mgL(-1) of BPA solution, the degradation rate of BPA exceeded 90% after treatment for only 30min under the optimum conditions...
February 27, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28274438/detection-of-unexpected-frauds-screening-and-quantification-of-maleic-acid-in-cassava-starch-by-fourier-transform-near-infrared-spectroscopy
#20
Hai-Yan Fu, He-Dong Li, Lu Xu, Qiao-Bo Yin, Tian-Ming Yang, Chuang Ni, Chen-Bo Cai, Ji Yang, Yuan-Bin She
Fourier transform near-infrared (FT-NIR) spectroscopy and chemometrics were adopted for the rapid analysis of a toxic additive, maleic acid (MA), which has emerged as a new extraneous adulterant in cassava starch (CS). After developing an untargeted screening method for MA detection in CS using one-class partial least squares (OCPLS), multivariate calibration models were subsequently developed using least squares support vector machine (LS-SVM) to quantitatively analyze MA. As a result, the OCPLS model using the second-order derivative (D2) spectra detected 0...
July 15, 2017: Food Chemistry
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