Carter M Lindborg, Mona Al Mukaddam, Genevieve Baujat, Tae-Joon Cho, Carmen L De Cunto, Patricia L R Delai, Elisabeth M W Eekhoff, Nobuhiko Haga, Edward C Hsiao, Rolf Morhart, Ruben de Ruiter, Christiaan Scott, Petra Seemann, Małgorzata Szczepanek, Jacek Tabarkiewicz, Robert J Pignolo, Frederick S Kaplan
BACKGROUND: Fibrodysplasia ossificans progressiva (FOP) is an ultrarare genetic disorder with episodic and progressive heterotopic ossification. Tissue trauma is a major risk factor for flareups, heterotopic ossification (HO), and loss of mobility in patients with FOP. The International Clinical Council on FOP generally recommends avoiding surgery in patients with FOP unless the situation is life-threatening, because soft tissue injury can trigger an FOP flareup. Surprisingly little is known about flareups, HO formation, and loss of mobility after fractures of the normotopic (occurring in the normal place, distinct from heterotopic) skeleton when treated nonoperatively in patients with FOP...
May 8, 2023: Clinical Orthopaedics and related Research