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Hearing loss in HIV positive patients

Guoyu Liu, Rong Hai, Fenyong Liu
Human cytomegalovirus (HCMV), a herpesvirus, is an important human pathogen that causes asymptomatic infections in healthy or immunocompetent individuals but can lead to severe and potentially life-threatening complications in immune-immature individuals such as neonates or immune-compromised patients such as organ-transplant recipients and HIV-positive individuals. Congenital HCMV infection represents a significant public health issue and poses substantial healthcare and economic burden to society. This virus causes the most common viral congenital infection worldwide, and is the leading non-genetic cause of sensorineural hearing loss in children in developed countries...
October 2017: Virologica Sinica
Martha F Mushi, Gustave Buname, Oliver Bader, Uwe Groß, Stephen E Mshana
BACKGROUND: Suppurative otitis media (SOM) is a major public health concern worldwide and is associated with increased morbidity. Cases of fungal suppurative otitis media were studied to establish the effect of fungi in otitis media. METHODS: Ear swabs from 410 patients were collected aseptically using sterile cotton swabs from discharging ear through perforated tympanic membrane. Swabs were subjected to microscopic and culture investigations. The species of fungal growing on Sabouraud's agar were identified using MALDI-TOF MS...
September 2, 2016: BMC Infectious Diseases
Martha F Mushi, Alfred E Mwalutende, Japhet M Gilyoma, Phillipo L Chalya, Jeremiah Seni, Mariam M Mirambo, Stephen E Mshana
BACKGROUND: Chronic suppurative otitis media (CSOM) is a major health problem in developing countries causing hearing loss and life threatening complications. Early and effective treatment based on the knowledge of causative micro-organisms and predictors of outcome are crucial in preventing these associated complications. This study was conducted to determine the predictors of CSOM complications, treatment outcome and antimicrobial susceptibility of pathogens, thus providing essential evidence to formulate a policy for management of CSOM...
2016: BMC Ear, Nose, and Throat Disorders
Jean Valentin F Fokouo, Jean Espoir E Vokwely, Jean Jacques N Noubiap, Brice Enid Nouthe, Joseline Zafack, Esthelle Stéphanie Minka Ngom, Asmaou Bouba Dalil, Adèle-Rose Ngo Nyeki, Géneviève Bengono, Richard Njock
IMPORTANCE: Human immunodeficiency virus (HIV) infection remains a major cause of morbidity and mortality worldwide. Many studies have found a higher prevalence of hearing impairment among HIV-positive individuals. OBJECTIVE: To investigate the effect of HIV and highly active antiretroviral treatment (HAART) on the hearing function in a Cameroonian population. DESIGN, SETTING, AND PARTICIPANTS: We conducted a prospective case-control study from March 1, 2012, through January 31, 2013...
May 1, 2015: JAMA Otolaryngology—Head & Neck Surgery
Ana Karina Lima Buriti, Simone Helena Dos Santos Oliveira, Lilian Ferreira Muniz
PURPOSE: To investigate the occurrence of hearing loss in children with HIV and its association with viral load, opportunistic diseases, and antiretroviral treatment. METHODS: A cross-sectional study was carried out with 23 HIV-positive children under care at two specialized centers in João Pessoa, Paraíba, Brazil. Their parents or legal guardians responded to a questionnaire, containing data on the clinical situation and the hearing health of the children, who were then submitted to audiological assessment...
December 16, 2013: CoDAS
B S Alabi, A K Salami, O A Afolabi, S K Aremu, H O Olawumi, L O Odeigah, H J Akande
BACKGROUND: HIV infection is the highest cause of death worldwide and presenting eventually with ENT regions. OBJECTIVE: This study is to determine the prevalence of hearing loss and hearing patterns among adults Nigerians with HIV and causal relationships between CD4+ counts with the degree of hearing impairments. METHODS: This prospective study was carried out among all consecutive HIV positive patients attending the clinic at the University of Ilorin teaching hospital (U...
January 2013: Nigerian Quarterly Journal of Hospital Medicine
Hossein Khalili, Farzaneh Dastan, Seyed Ali Dehghan Manshadi
OBJECTIVE: A case with reversible symmetrical sensorineural hearing loss following hydroxychloroquine therapy is described. CASE SUMMARY: A 57-year-old, human immunodeficiency virus (HIV) positive man was referred to the HIV clinic of Imam Khomeini Hospital, Tehran with chief complaint of bilateral slowly progressive hearing loss starting from two months ago. The man had history of rheumatoid arthritis diagnosed from 3 months ago and was administered hydroxychloroquine 200 mg and prednisolone 5 mg twice daily...
2014: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
M Tshifularo, L Govender, G Monama
BACKGROUND: Sub-Saharan Africa has the highest incidence of HIV infection. According to recent census statistics, 5.6 million people in South Africa (SA) are HIV-positive, the highest number of infected individuals worldwide. Over 80% of HIV-infected individuals will present with ear, nose and throat (ENT) manifestations. Previous studies show that oral diseases seem to be the most common ENT-related manifestation, reported in about 40 - 50% of HIV-infected patients. In SA, there is lack of local information regarding the otolaryngological and head and neck manifestations in HIV-infected individuals...
May 16, 2013: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
B A Ongulo, H O Oburra
OBJECTIVES: To determine the prevalence and type of hearing disorders in HIV positive patients not on anti - retroviral drugs (ARVs) and correlate this with the world health Organization (WHO) stage of HIV disease and CD4 positive cell counts. DESIGN: Case control study. SETTING: Comprehensive Care Clinic (CCC) and Voluntary Counseling and testing centre at Kenyatta National Hospital. SUBJECTS: One hundread and ninety four HIV positive patients attending CCC and 124 HIV negative subjects recruited from voluntary counseling and testing (VCT) centre...
September 2010: East African Medical Journal
Ndoleriire Christopher, Turitwenka Edward, Bakeera-Kitaaka Sabrina, Nyabigambo Agnes
INTRODUCTION: Hearing impairment is one form of disability in children living with HIV/AIDS. It greatly interferes with their language development, communication and performance. These are stressful to the children and their caretakers. With increasing availability of free anti-retroviral therapy, children with HIV/AIDS are living much longer. Therefore efforts must be made to reduce the disability resulting from hearing impairment among children living with HIV. OBJECTIVE: The objective of this study was to determine the prevalence, types and severity of hearing loss in HIV positive pediatric patients between 6 months and 5 years of age attending PIDC, Mulago Hospital Uganda...
February 2013: International Journal of Pediatric Otorhinolaryngology
Suma Susan Mathews, Rita Ruby Albert, Anand Job
OBJECTIVE: As the acquired immunodeficiency syndrome (AIDS) epidemic shows no signs of abating, the impact of AIDS is felt more in the developing countries due to socioeconomic reasons. The possibility of drug-induced ototoxicity also adds to the risk of audio vestibular dysfunction. We sought to determine if there was a difference between the audio-vestibular function in the asymptomatic human immunodeficiency virus (HIV) infected patients and patients with AIDS. STUDY DESIGN: A prospective, cross-sectional study SETTING: A tertiary care center in South India MATERIALS AND METHODS: The audio-vestibular system of 30 asymptomatic HIV positive subjects (group 1) and 30 subjects with AIDS (group 2), and age-matched 30 healthy controls (group 3) were assessed using pure tone audiometry and cold caloric test...
July 2012: Indian Journal of Sexually Transmitted Diseases
Daniel Bella Devaleenal, Nagalingeswaran Ahilasamy, Suniti Solomon, Nagalingeswaran Kumarasamy
We report a case of 45-yr-old HIV positive male who presented with herpes zoster oticus at the time of diagnosis of his HIV status. The patient had vertigo, painful vesicular eruptions on the right ear and unilateral sensorineural hearing loss. The etiology, diagnosis and treatment of herpes zoster are discussed in detail in this report. We report this case to raise awareness among the general practitioners to investigate for HIV when they diagnose cases of herpes zoster.
June 2008: Indian Journal of Otolaryngology and Head and Neck Surgery
S M Makau, B A Ongulo, P Mugwe
OBJECTIVES: To determine if patients on Anti-retroviral drugs (ARVs) develop hearing impairment. DESIGN: The comprehensive care clinic (CCC), Kenyatta National Hospital (KNH), Nairobi. SETTING: Case controlled study. SUBJECTS: Two hundred and seventy one human immunodeficiency virus (HIV) positive patients on ARVs were matched for age and sex with 273 HIV positive patients who were not on ARVs. RESULTS: Thirty four percent of HIV positive patients not on ARVs had a hearing loss compared to only 28% in patients who were on ARVs...
October 2010: East African Medical Journal
Yolandé van der Westhuizen, De Wet Swanepoel, Barbara Heinze, Louis Murray Hofmeyr
OBJECTIVES: This study describes the prevalence and nature of auditory and otological manifestations in adults with HIV/AIDS through clinical examinations and self-reported symptoms across stages of disease progression. DESIGN: Descriptive cross-sectional group design. STUDY SAMPLE: Two hundred HIV positive adult patients (56.5% male; 43.5% female; mean age: 37.99 ± 6.66 years) attending the Infectious Disease Clinic of a tertiary referral hospital in Pretoria, South Africa were included...
January 2013: International Journal of Audiology
Tashneem Harris, Soraya Bardien, H Simon Schaaf, Lucretia Petersen, Greetje De Jong, Johannes J Fagan
Background. Ototoxicity following aminoglycoside treatment for multidrug-resistant tuberculosis (MDR-TB) is a significant problem. This study documents the incidence of ototoxicity in HIV-positive and HIV-negative patients with MDR-TB and presents clinical guidelines relating to ototoxicity. Methods. A prospective cohort study of 153 MDR-TB patients with normal hearing and middle ear status at baseline controlling for 6 mitochondrial mutations associated with aminoglycoside-related ototoxicity, at Brooklyn Chest Hospital in Cape Town...
June 2012: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Varaporn Sangtawesin, Yupayao Singarj, Wiboon Kanjanapattanakul
BACKGROUND: The number of very low birth weight (VLBW) births is increasing worldwide. Despite better care in recent years, they have a high incidence of delayed growth and development. There are no previous studies regarding the growth and development of these infants at Queen Sirikit National Institute of Child Health (QSNICH). OBJECTIVE: To study growth and developmental outcome of VLBW infants, aged 18-24 months who were discharged from QSNICH. MATERIAL AND METHOD: VLBW infants who were discharged from QSNICH during the year 2007 were recruited in the study...
August 2011: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Bruce John McKenzie, J W Loock
We present a case report and review the world literature concerning otosyphilis, particularly with reference to the HIV positive patient. Our patient received two separate courses of treatment for otosyphilis. A course of intramuscular penicillin and oral prednisone resulted in no improvement in his hearing thresholds. A subsequent course of intravenous penicillin and oral prednisone resulted in an improvement of 79 db in his three frequency pure tone average. Otosyphilis is one of the rare causes of treatable sensorineural hearing loss...
2009: BMJ Case Reports
Andrêza Batista Cheloni Vieira, Dirceu Bartolomeu Greco, Márcia Miliane Maciel Teófilo, Denise Utsch Gonçalves
Ototoxicity and antiretroviral therapy seem to be associated. The aim of this study was to evaluate this possible correlation. Evaluations were carried out on 779 medical records from HIV-infected patients who were being regularly followed up, of whom 162 were being treated with antiretroviral therapy and 122 were untreated (controls). The patients undergoing treatment were older (mean: 42 years), had had serological confirmation for longer times (80 months) and had smaller viral loads (P = 0.00). CD4+ was similar between the groups (P = 0...
January 2008: Revista da Sociedade Brasileira de Medicina Tropical
Sharmistha Mishra, Sharon Lynn Walmsley, Mona Rafik Loutfy, Rupert Kaul, Kenneth John Logue, Wayne Lawrence Gold
We sought to identify and review the clinical features and treatment outcomes of eight recent cases of otosyphilis in HIV-positive patients seen in Toronto. All patients reported tinnitus, and seven (87.5%) reported subjective hearing loss. Not taking auditory findings into consideration, four patients would be classified as having secondary syphilis, three patients as having early latent syphilis, and one patient as having latent syphilis of unknown duration. The median CD4 cell count was 370 x 10(6)/L. All patients were treated with intravenous aqueous penicillin G with regimens recommended for the treatment of neurosyphilis; four patients received adjunctive steroids...
March 2008: AIDS Patient Care and STDs
Matthew Scarborough, Stephen B Gordon, Christopher J M Whitty, Neil French, Yasin Njalale, Alex Chitani, Timothy E A Peto, David G Lalloo, Eduard E Zijlstra
BACKGROUND: In sub-Saharan Africa, bacterial meningitis is common and is associated with a high mortality. Adjuvant therapy with corticosteroids reduces mortality among adults in the developed world, but it has not been adequately tested in developing countries or in the context of advanced human immunodeficiency virus (HIV) infection. METHODS: We conducted a randomized, double-blind, placebo-controlled trial of dexamethasone (16 mg twice daily for 4 days) and an open-label trial of intramuscular versus intravenous ceftriaxone (2 g twice daily for 10 days) in adults with an admission diagnosis of bacterial meningitis in Blantyre, Malawi...
December 13, 2007: New England Journal of Medicine
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