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https://www.readbyqxmd.com/read/28214017/genetic-risk-factors-for-ovarian-cancer-and-their-role-for-endometriosis-risk
#1
Stefanie Burghaus, Peter A Fasching, Lothar Häberle, Matthias Rübner, Kathrin Büchner, Simon Blum, Anne Engel, Arif B Ekici, Arndt Hartmann, Alexander Hein, Matthias W Beckmann, Stefan P Renner
OBJECTIVE: Several genetic variants have been validated as risk factors for ovarian cancer. Endometriosis has also been described as a risk factor for ovarian cancer. Identifying genetic risk factors that are common to the two diseases might help improve our understanding of the molecular pathogenesis potentially linking the two conditions. METHODS: In a hospital-based case-control analysis, 12 single nucleotide polymorphisms (SNPs), validated by the Ovarian Cancer Association Consortium (OCAC) and the Collaborative Oncological Gene-environment Study (COGS) project, were genotyped using TaqMan® OpenArray™ analysis...
February 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28212394/de-novo-transcriptome-analysis-and-microsatellite-marker-development-for-population-genetic-study-of-a-serious-insect-pest-rhopalosiphum-padi-l-hemiptera-aphididae
#2
Xinle Duan, Kang Wang, Sha Su, Ruizheng Tian, Yuting Li, Maohua Chen
The bird cherry-oat aphid, Rhopalosiphum padi (L.), is one of the most abundant aphid pests of cereals and has a global distribution. Next-generation sequencing (NGS) is a rapid and efficient method for developing molecular markers. However, transcriptomic and genomic resources of R. padi have not been investigated. In this study, we used transcriptome information obtained by RNA-Seq to develop polymorphic microsatellites for investigating population genetics in this species. The transcriptome of R. padi was sequenced on an Illumina HiSeq 2000 platform...
2017: PloS One
https://www.readbyqxmd.com/read/28209594/adolescents-and-young-adults-with-acute-lymphoblastic-leukemia-and-acute-myeloid-leukemia-impact-of-care-at-specialized-cancer-centers-on-survival-outcome
#3
Julie Wolfson, Can-Lan Sun, Laura Wyatt, Wendy Stock, Smita Bhatia
Background: Adolescents and young adults (AYA; 15-39 years) with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) experience inferior survival when compared with children. Impact of care at NCI-designated Comprehensive Cancer Centers (CCC) or Children's Oncology Group sites (COG) on survival disparities remains unstudied.Methods: Using the Los Angeles cancer registry, we identified 1,870 ALL or AML patients between 1 and 39 years at diagnosis. Cox regression analyses assessed risk of mortality; younger age + CCC/COG served as the referent group...
February 16, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28196965/genomic-microdiversity-of-bifidobacterium-pseudocatenulatum-underlying-differential-strain-level-responses-to-dietary-carbohydrate-intervention
#4
Guojun Wu, Chenhong Zhang, Huan Wu, Ruirui Wang, Jian Shen, Linghua Wang, Yufeng Zhao, Xiaoyan Pang, Xiaojun Zhang, Liping Zhao, Menghui Zhang
The genomic basis of the response to dietary intervention of human gut beneficial bacteria remains elusive, which hinders precise manipulation of the microbiota for human health. After receiving a dietary intervention enriched with nondigestible carbohydrates for 105 days, a genetically obese child with Prader-Willi syndrome lost 18.4% of his body weight and showed significant improvement in his bioclinical parameters. We obtained five isolates (C1, C15, C55, C62, and C95) of one of the most abundantly promoted beneficial species, Bifidobacterium pseudocatenulatum, from a postintervention fecal sample...
February 14, 2017: MBio
https://www.readbyqxmd.com/read/28196101/de-novo-assembly-characterization-and-annotation-for-the-transcriptome-of-sarcocheilichthys-sinensis
#5
Chuankun Zhu, Zhengjun Pan, Hui Wang, Guoliang Chang, Nan Wu, Huaiyu Ding
The Chinese lake gudgeon Sarcocheilichthys sinensis is a small cyprinid fish with great aquaculture potential both for its edible and ornamental values. Nevertheless, available genomic and transcriptomic information for this fish is extremely deficient. In this study, a normalized cDNA library was constructed using 13 mixed tissues of an adult male S. sinensis, and was sequenced by the Illumina HiSeq2500 platform. De novo assembly was performed using 38,911,511 obtained clean reads, and a total of 147,282 unigenes with an average length of 900 bp were finally achieved...
2017: PloS One
https://www.readbyqxmd.com/read/28187311/candidate-chemosensory-genes-identified-in-the-endoparasitoid-meteorus-pulchricornis-hymenoptera-braconidae-by-antennal-transcriptome-analysis
#6
Sheng Sheng, Cheng-Wu Liao, Yu Zheng, Yu Zhou, Yan Xu, Wen-Miao Song, Peng He, Jian Zhang, Fu-An Wu
Meteorus pulchricornis is an endoparasitoid wasp which attacks the larvae of various lepidopteran pests. We present the first antennal transcriptome dataset for M. pulchricornis. A total of 48,845,072 clean reads were obtained and 34,967 unigenes were assembled. Of these, 15,458 unigenes showed a significant similarity (E-value <10(-5)) to known proteins in the NCBI non-redundant protein database. Gene ontology (GO) and cluster of orthologous groups (COG) analyses were used to classify the functions of M...
January 31, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28186867/significant-improvement-in-cognition-in-mild-to-moderately-severe-dementia-cases-treated-with-transcranial-plus-intranasal-photobiomodulation-case-series-report
#7
Anita E Saltmarche, Margaret A Naeser, Kai Fai Ho, Michael R Hamblin, Lew Lim
OBJECTIVE: This study investigated whether patients with mild to moderately severe dementia or possible Alzheimer's disease (AD) with Mini-Mental State Exam (MMSE) Baseline scores of 10-24 would improve when treated with near-infrared photobiomodulation (PBM) therapy. BACKGROUND: Animal studies have presented the potential of PBM for AD. Dysregulation of the brain's default mode network (DMN) has been associated with AD, presenting the DMN as an identifiable target for PBM...
February 10, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28181037/de-novo-transcriptome-characterization-and-growth-related-gene-expression-profiling-of-diploid-and-triploid-bighead-catfish-clarias-macrocephalus-g%C3%A3-nther-1864
#8
Satid Chatchaiphan, Prapansak Srisapoome, Jin-Hyoung Kim, Robert H Devlin, Uthairat Na-Nakorn
To enhance understanding of triploid gene expression, the transcriptome information from bighead catfish (Clarias macrocephalus Günther, 1864) was studied using the paired-end Illumina HiSeq™ 2000 sequencing platform. In total, 68,227,832 raw reads were generated from liver tissues and 53,149 unigenes were assembled, with an average length of 765 bp and N50 length of 1283 bp. Of these unigenes, 33,428 (62.89%) could be annotated according to their homology with matches in the NCBI non-redundant (Nr), NCBI nucleotide (Nt), Swiss-Prot, Clusters of Orthologous Groups (COG), gene ontology (GO), or Kyoto Encyclopedia of Genes and Genomes (KEGG) databases...
February 8, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28181001/a-critique-and-empirical-assessment-of-alexandra-horowitz-and-julie-hecht-s-examining-dog-human-play-the-characteristics-affect-and-vocalizations-of-a-unique-interspecific-interaction
#9
Robert W Mitchell
Horowitz and Hecht (Anim Cog 19:779-788, 2016) presented data about activities and vocalizations during brief videotaped dog-owner play provided by owners, examined these in relation to human affect during play, and made comparisons from their results to other research on activities and vocalizations during dog-human play. In this critique, I describe problems with Horowitz and Hecht's methodology, analyses, and evidence; in their interpretations of the data, evidence, and categorizations provided in other research, particularly my own studies of dog-human play; and in their claims of novelty for their findings...
February 8, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28161983/prospective-correlates-of-early-30%C3%A2-day-readmissions-on-a-cardiothoracic-surgery-service
#10
Mark W Ketterer, Mansi Chawa, Gaetano Paone
Known to vary widely among hospitals for unclear reasons, early readmissions are associated with higher mortality and are suspected to frequently be due to inadequate discharge preparation/planning. It has been previously documented that the strongest and most consistent predictor of early readmissions in CHF patients is chronic cognitive impairment, and compensatory assistance with adherence on discharge improves early readmission rates. Prospective observational study. The present investigation examined multiple putative perioperative predictors of early readmission in a hospitalized Cardiothoracic Surgery Service...
February 6, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28161090/repetitive-transcranial-magnetic-stimulation-combined-with-cognitive-training-for-the-treatment-of-alzheimer-s-disease
#11
Jean-Paul Nguyen, Alcira Suarez, Gilles Kemoun, Michel Meignier, Estelle Le Saout, Philippe Damier, Julien Nizard, Jean-Pascal Lefaucheur
OBJECTIVE: To assess the efficacy of a combination of cognitive training (COG) and repetitive transcranial magnetic stimulation (rTMS), on cognitive performance, locomotor activity, apathy, caregiver burden and dependence of patients with Alzheimer's disease (AD). METHODS: A combination of COG and rTMS was performed in 10 patients with AD (NeuroAD procedure) for a period of 5weeks (one session per day, 5days a week), without maintenance sessions. Patients were evaluated at the end of the treatment (D45) and 6months later (M6) by the Mini Mental State Examination (MMSE), the Alzheimer disease assessment scale - cognitive subscale (ADAS-Cog), various neuropsychological tests and clinical scores specific for locomotor activity, apathy, caregiver burden, and dependence, recorded before the study (baseline)...
February 1, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28146330/using-electronic-medical-record-data-to-report-laboratory-adverse-events
#12
Tamara P Miller, Yimei Li, Kelly D Getz, Jesse Dudley, Evanette Burrows, Jeffrey Pennington, Azada Ibrahimova, Brian T Fisher, Rochelle Bagatell, Alix E Seif, Robert Grundmeier, Richard Aplenc
Despite the importance of adverse event (AE) reporting, AEs are under-reported on clinical trials. We hypothesized that electronic medical record (EMR) data can ascertain laboratory-based AEs more accurately than those ascertained manually. EMR data on 12 AEs for patients enrolled on two Children's Oncology Group (COG) trials at one institution were extracted, processed and graded. When compared to gold standard chart data, COG AE report sensitivity and positive predictive values (PPV) were 0-21·1% and 20-100%, respectively...
February 1, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28132089/effects-of-compensatory-cognitive-training-intervention-for-breast-cancer-patients-undergoing-chemotherapy-a-pilot-study
#13
Jin-Hee Park, Yong Sik Jung, Ku Sang Kim, Sun Hyoung Bae
PURPOSE: Numerous breast cancer patients experience cognitive changes during and after chemotherapy. Chemotherapy-related cognitive impairment can significantly affect quality of life. This pilot study attempted to determine the effects of a compensatory cognitive training on the objective and subjective cognitive functioning of breast cancer patients receiving adjuvant chemotherapy. METHODS: Fifty-four patients were assigned to either a compensatory cognitive training or waitlist condition...
January 28, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28131953/whole-genome-resequencing-of-bacillus-cereus-and-expression-of-genes-functioning-in-sodium-chloride-stress
#14
Zhenbo Xu, Jinhong Xie, Junyan Liu, Lili Ji, Thanapop Soteyome, Brian M Peters, Dingqiang Chen, Bing Li, Lin Li, Mark E Shirtliff
Bacillus cereus is one of the most common opportunistic pathogens responsible for various foodborn diseases. To investigate the regulatory mechanism of B. cereus under high osmotic pressure, two B. cereus strains B25 and B26 were isolated from the industrial soy sauce residue containing high-salt concentration. Resequencing was performed by Illumina/Solexa platform and 13,646 SNPs and 434 InDels were identified as common variants between B25 and B26 against reference genome, followed by COG, GO, and KEGG enrichment analysis...
January 25, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28131207/the-correlation-between-cerebral-arterial-pulsatility-and-cognitive-dysfunction-in-alzheimer-s-disease-patients
#15
Jae-Sung Lim, Jee Young Lee, Hyung-Min Kwon, Yong-Seok Lee
BACKGROUND: Potential role of vascular dysfunction has been suggested in the pathogenesis of Alzheimer's disease (AD). Previous cross-sectional studies have demonstrated relations between abnormal transcranial Doppler (TCD) parameters and cognitive impairment. We aimed to investigate the associations between longitudinal changes of TCD parameters and cognitive decline in patients with AD. METHODS: We have enrolled patients with mild to moderate AD who aged 60 to 79years...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28128435/vitamin-e-for-alzheimer-s-dementia-and-mild-cognitive-impairment
#16
REVIEW
Nicolas Farina, David Llewellyn, Mokhtar Gad El Kareem Nasr Isaac, Naji Tabet
BACKGROUND: Vitamin E occurs naturally in the diet. It has several biological activities, including functioning as an antioxidant to scavenge toxic free radicals. Evidence that free radicals may contribute to the pathological processes behind cognitive impairment has led to interest in the use of vitamin E supplements to treat mild cognitive impairment (MCI) and Alzheimer's disease (AD). This is an update of a Cochrane Review first published in 2000, and previously updated in 2006 and 2012...
January 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28127511/high-angular-resolution-diffusion-imaging-tractography-of-cerebellar-pathways-from-newborns-to-young-adults
#17
Thomas J Re, Jacob Levman, Ashley R Lim, Andrea Righini, Patricia Ellen Grant, Emi Takahashi
INTRODUCTION: Many neurologic and psychiatric disorders are thought to be due to, or result in, developmental errors in neuronal cerebellar connectivity. In this connectivity analysis, we studied the developmental time-course of cerebellar peduncle pathways in pediatric and young adult subjects. METHODS: A cohort of 80 subjects, newborns to young adults, was studied on a 3T MR system with 30 diffusion-weighted measurements with high-angular resolution diffusion imaging (HARDI) tractography...
January 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28118425/entropy-of-masseter-muscle-pain-sensitivity-a-new-technique-for-pain-assessment
#18
Eduardo E Castrillon, Fernando G Exposto, Hitoshi Sato, Tomohiro Tanosoto, Taro Arima, Lene Baad-Hansen, Peter Svensson
AIMS: To test whether manipulation of mechanical pain sensitivity (MPS) of the masseter muscle is reflected in quantitative measures of entropy. METHODS: In a randomized, single-blinded, placebo-controlled design, 20 healthy volunteers had glutamate, lidocaine, and isotonic saline injected into the masseter muscle. Self-assessed pain intensity on a numeric rating scale (NRS) was evaluated up to 10 minutes following the injection, and MPS was evaluated after application (at 5 minutes and 30 minutes) of three different forces (0...
January 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28113094/validity-of-the-modified-berg-balance-scale-in-adults-with-intellectual-and-visual-disabilities
#19
Annemarie Dijkhuizen, Wim P Krijnen, Cees P van der Schans, Aly Waninge
BACKGROUND: A modified version of the Berg Balance Scale (mBBS) was developed for individuals with intellectual and visual disabilities (IVD). However, the concurrent and predictive validity has not yet been determined. AIM: The purpose of the current study was to evaluate the concurrent and predictive validity of the mBBS for individuals with IVD. METHOD: Fifty-four individuals with IVD and Gross Motor Functioning Classification System (GMFCS) Levels I and II participated in this study...
January 20, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28111997/effect-of-elastic-bandage-on-postural-control-in-subjects-with-chronic-ankle-instability-a-randomised-clinical-trial
#20
Isabel M Alguacil-Diego, Carlos de-la-Torre-Domingo, Antonio López-Román, Juan Carlos Miangolarra-Page, Francisco Molina-Rueda
PURPOSE: To report the immediate and prolonged (one week) effects of elastic bandage (EB) on balance control in subjects with chronic ankle instability. MATERIAL AND METHODS: Twenty-eight individuals successfully completed the study protocol, of whom 14 were randomly assigned to the EB group (7 men, 7 women) and 14 were assigned to the non-standardised tape (NST) group (9 men, 5 women). To objectively measure postural sway we used computerised dynamic posturography (CDP) with sensory organisation test (SOT) and unilateral stance (US) test...
January 23, 2017: Disability and Rehabilitation
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