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https://www.readbyqxmd.com/read/28630801/characterization-of-the-transcriptome-and-est-ssr-development-in-boea-clarkeana-a-desiccation-tolerant-plant-endemic-to-china
#1
Ying Wang, Kun Liu, De Bi, Shoubiao Zhou, Jianwen Shao
BACKGROUND: Desiccation-tolerant (DT) plants can recover full metabolic competence upon rehydration after losing most of their cellular water (>95%) for extended periods of time. Functional genomic approaches such as transcriptome sequencing can help us understand how DT plants survive and respond to dehydration, which has great significance for plant biology and improving the drought tolerance of crops. Boea clarkeana Hemsl. (Gesneriaceae) is a DT dicotyledonous herb. Its genomic sequences characteristics remain unknown...
2017: PeerJ
https://www.readbyqxmd.com/read/28627726/the-arl3-and-arl1-gtpase-cooperates-with-cog8-to-regulate-selective-autophagy-via-atg9-trafficking
#2
I-Hao Wang, Yi-Jie Chen, Jia-Wei Hsu, Fang-Jen S Lee
The Arl3-Arl1 GTPase cascade plays important roles in vesicle trafficking at the late Golgi and endosomes. Subunits of the conserved oligomeric Golgi (COG) complex, a tethering factor, are important for endosome-to-Golgi transport and contribute to the efficient functioning of the cytoplasm-to-vacuole (Cvt) pathway, a well-known selective autophagy pathway. According to our findings, the Arl3-Arl1 GTPase cascade cooperates with Cog8 to regulate the Cvt pathway via Atg9 trafficking. arl3cog8Δ and arl1cog8Δ exhibit profound defects in aminopeptidase I maturation in rich medium...
June 19, 2017: Traffic
https://www.readbyqxmd.com/read/28626468/efficacy-and-safety-of-mlc601-in-the-treatment-of-mild-cognitive-impairment-a-pilot-randomized-double-blind-placebo-controlled-study
#3
Hossein Pakdaman, Ali Amini Harandi, Mehdi Abbasi, Hosein Delavar Kasmaei, Farzad Ashrafi, Koroush Gharagozli, Farhad Assarzadegan, Behdad Behnam, Mehran Arabahmadi
BACKGROUND AND AIM: Mild cognitive impairment (MCI) is characterized by declined cognitive function greater than that expected for a person's age. The clinical significance of this condition is its possible progression to dementia. MLC601 is a natural neuroprotective medication that has shown promising effects in Alzheimer disease. Accordingly, we conducted this randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of MLC601 in MCI patients. METHODS: Seventy-two patients with a diagnosis of MCI were recruited...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28625866/genome-analysis-of-crude-oil-degrading-franconibacter-pulveris-strain-dj34-revealed-its-genetic-basis-for-hydrocarbon-degradation-and-survival-in-oil-contaminated-environment
#4
Siddhartha Pal, Anirban Kundu, Tirtha Das Banerjee, Balaram Mohapatra, Ajoy Roy, Riddha Manna, Pinaki Sar, Sufia K Kazy
Franconibacter pulveris strain DJ34, isolated from Duliajan oil fields, Assam, was characterized in terms of its taxonomic, metabolic and genomic properties. The bacterium showed utilization of diverse petroleum hydrocarbons and electron acceptors, metal resistance, and biosurfactant production. The genome (4,856,096bp) of this strain contained different genes related to the degradation of various petroleum hydrocarbons, metal transport and resistance, dissimilatory nitrate, nitrite and sulfite reduction, chemotaxy, biosurfactant synthesis, etc...
June 15, 2017: Genomics
https://www.readbyqxmd.com/read/28625273/development-of-a-core-outcome-set-for-disease-modification-trials-in-mild-to-moderate-dementia-a-systematic-review-patient-and-public-consultation-and-consensus-recommendations
#5
Lucy Webster, Derek Groskreutz, Anna Grinbergs-Saull, Rob Howard, John T O'Brien, Gail Mountain, Sube Banerjee, Bob Woods, Robert Perneczky, Louise Lafortune, Charlotte Roberts, Jenny McCleery, James Pickett, Frances Bunn, David Challis, Georgina Charlesworth, Katie Featherstone, Chris Fox, Claire Goodman, Roy Jones, Sallie Lamb, Esme Moniz-Cook, Justine Schneider, Sasha Shepperd, Claire Surr, Jo Thompson-Coon, Clive Ballard, Carol Brayne, Orlaith Burke, Alistair Burns, Linda Clare, Peter Garrard, Patrick Kehoe, Peter Passmore, Clive Holmes, Ian Maidment, Fliss Murtagh, Louise Robinson, Gill Livingston
BACKGROUND: There is currently no disease-modifying treatment available to halt or delay the progression of the disease pathology in dementia. An agreed core set of the best-available and most appropriate outcomes for disease modification would facilitate the design of trials and ensure consistency across disease modification trials, as well as making results comparable and meta-analysable in future trials. OBJECTIVES: To agree a set of core outcomes for disease modification trials for mild to moderate dementia with the UK dementia research community and patient and public involvement (PPI)...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28624876/morphological-and-molecular-characterization-of-a-new-cyprinid-gall-bladder-infecting-chloromyxum-species-chloromyxum-peleci-sp-n-myxozoa-chloromyxidae-from-pelecus-cultratus-l-in-russia
#6
X H Liu, V N Voronin, A S Dudin, D A Morozova, J Y Zhang
Extensive sampling to get rich data is very important to resolve the current taxonomic problem of Chloromyxum genus and elucidate the nature phylogenetic relationships among congeneric species. During the parasitological survey of cyprinid fish in Gulf of Finland off the coast of St. Petersburg, a new Chloromyxum species, named as Chloromyxum peleci sp. n., was found to infect the gall bladder of sichel, Pelecus cultratus (L.). Here, we provided the morphological, ultrastructural, and molecular features to describe it...
June 18, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28619360/further-delineation-of-cog8-cdg-a-case-with-novel-compound-heterozygous-mutations-diagnosed-by-targeted-exome-sequencing
#7
Aram Yang, Sung Yoon Cho, Ja-Hyun Jang, Jinsup Kim, Sook Za Kim, Beom Hee Lee, Han-Wook Yoo, Dong-Kyu Jin
Congenital disorders of glycosylation (CDG) are a rapidly expanding group of inherited metabolic disorders with highly variable clinical presentations caused by deficient glycosylation of proteins and/or lipids. CDG-IIh is a very rare subgroup of CDG caused by mutations in the conserved oligomeric Golgi (COG) complex gene, COG8, and so far, only two cases have been reported in the medical literature. Here, we describe an 8-year-old Korean boy with psychomotor retardation, hypotonia, failure to thrive, elevated serum liver enzymes, microcephaly, and talipes equinovarus...
June 13, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28618920/castor-oil-for-induction-of-labour-a-retrospective-study
#8
Isabella Neri, Giulia Dante, Lucrezia Pignatti, Chiara Salvioli, Fabio Facchinetti
PURPOSE: The aim of this study is to investigate the safety and efficacy of castor oil to induce labour. MATERIALS AND METHODS: A retrospective observational case control study was conducted over five years. Castor oil was proposed to women referred to the Birth Centre (Castor Oil group (COG)). They were compared to women who chose to be followed by the traditional doctor-led unit (control group (CG)). Castor oil was administered in a 60 ml single dose in 200 ml of warm water...
June 15, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28614366/de-novo-transcriptomic-analysis-and-development-of-est-ssrs-for-sorbus-pohuashanensis-hance-hedl
#9
Congcong Liu, Ying Dou, Xuelian Guan, Qiang Fu, Ze Zhang, Zenghui Hu, Jian Zheng, Yizeng Lu, Wei Li
Sorbus pohuashanensis is a native tree species of northern China that is used for a variety of ecological purposes. The species is often grown as an ornamental landscape tree because of its beautiful form, silver flowers in early summer, attractive pinnate leaves in summer, and red leaves and fruits in autumn. However, development and further utilization of the species are hindered by the lack of comprehensive genetic information, which impedes research into its genetics and molecular biology. Recent advances in de novo transcriptome sequencing (RNA-seq) technology have provided an effective means to obtain genomic information from non-model species...
2017: PloS One
https://www.readbyqxmd.com/read/28596794/efficacy-and-safety-of-an-herbal-therapy-in-patients-with-amnestic-mild-cognitive-impairment-a-24-week-randomized-phase-iii-trial
#10
Jinzhou Tian, Jing Shi, Tao Li, Lin Li, Zhiliang Wang, Xiaobin Li, Zhu Lv, Qingshan Zheng, Mingqing Wei, Yongyan Wang
OBJECTIVE: In the 24-week randomized, double-blind, double-placebo, parallel-controlled trial, we aimed to test the effects of herbal therapy with amnestic mild cognitive impairment (aMCI). METHODS: A total of 324 patients with aMCI entered a 2-week placebo run-in period followed by 24 weeks' treatment of either (a) herbal capsule (5 shenwu capsules/administration, 3 times/day) and placebo identical to donepezil tablets (n = 216) or (b) donepezil (5 mg/day) and placebo identical to herbal capsule (n = 108)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28589562/the-complete-genome-sequence-of-exiguobacterium-arabatum-w-01-reveals-potential-probiotic-functions
#11
Meinan Cong, Qingling Jiang, Xiaojin Xu, Lixing Huang, Yongquan Su, Qingpi Yan
Shrimp is extensively cultured worldwide. Shrimp farming is suffering from a variety of diseases. Probiotics are considered to be one of the effective methods to prevent and cure shrimp diseases. Exiguobacterium arabatum W-01, a gram-positive and orange-pigmented bacterium, was isolated from the intestine of a healthy Penaeus vannamei specimen. Whole-genome sequencing revealed a genome of 2,914,854 bp, with 48.02% GC content. In total, 3,083 open reading frames (ORFs) were identified, with an average length of 843...
June 6, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28581686/tongue-palatal-contact-changes-in-patients-with-skeletal-mandibular-prognathism-after-ssro-an-electropalatography-study
#12
S Kojima, M Kaku, I Yamamoto, Y Yasuhara, H Sumi, T Yamamoto, Y Yashima, J Izumino, K Nakajima, Y Nagano, M Kono, A Yoshimura, M Ueasa, K Tanimoto
The purpose of this study was to investigate the changes in tongue-palatal contact patterns using electropalatography (EPG) before and after sagittal split ramus osteotomy (SSRO) in patients with mandibular prognathism. Nine clients who underwent SSRO for mandibular setback and seven control subjects were participated in this study. Tongue-palatal contact patterns for /t/, /s/ and /k/ production were investigated using EPG before surgery and 3 months after surgery. The mean value of whole total of palate contact (WT) in the maximum contact frame was examined before and after SSRO...
June 5, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28574782/rna-based-ovarian-cancer-research-from-a-gene-to-systems-biomedicine-perspective
#13
Esra Gov, Medi Kori, Kazim Yalcin Arga
Ovarian cancer remains the leading cause of death from a gynecologic malignancy, and treatment of this disease is harder than any other type of female reproductive cancer. Improvements in the diagnosis and development of novel and effective treatment strategies for complex pathophysiologies, such as ovarian cancer, require a better understanding of disease emergence and mechanisms of progression through systems medicine approaches. RNA-level analyses generate new information that can help in understanding the mechanisms behind disease pathogenesis, to identify new biomarkers and therapeutic targets and in new drug discovery...
August 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28571968/determination-of-the-protein-expression-profiles-of-propsilocerus-akamusi-tokunaga-malpighian-tubules-response-to-cadmium-stress-by-itraq-coupled-lc-ms-ms
#14
Xianyun Zheng, Zhiying Xie, Shu Wang, Pipeng Lin
Propsilocerus akamusi (Tokunaga) is an important prey species for fish and aquatic birds, which represent an important link in the aquatic food chain as other species of Chironomidae. Malpighian tubules (MT) play an important role in metabolism and detoxification of harmful compounds and metal accumulation. Our previous studies have reported that P. akamusi have an extraordinary resistance to Cd. In this paper, iTRAQ-based proteomics technology was first used to study the differential proteomics of MT of Propsilocerus akamusi under sublethal Cd stress for different time courses...
May 29, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28570707/de-novo-characterization-of-the-pine-aphid-cinara-pinitabulaeformis-zhang-et-zhang-transcriptome-and-analysis-of-genes-relevant-to-pesticides
#15
Songqing Wu, Zhicheng Huang, Carballar-Lejarazú Rebeca, Xiaoli Zhu, Yajie Guo, Qiannan Lin, Xia Hu, Rong Wang, Guanghong Liang, Xiong Guan, Feiping Zhang
The pine aphid Cinara pinitabulaeformis Zhang et Zhang is the main pine pest in China, it causes pine needles to produce dense dew (honeydew) which can lead to sooty mold (black filamentous saprophytic ascomycetes). Although common chemical and physical strategies are used to prevent the disease caused by C. pinitabulaeformis Zhang et Zhang, new strategies based on biological and/or genetic approaches are promising to control and eradicate the disease. However, there is no information about genomics, proteomics or transcriptomics to allow the design of new control strategies for this pine aphid...
2017: PloS One
https://www.readbyqxmd.com/read/28558714/feasibility-and-efficacy-of-a-multi-factorial-intervention-to-prevent-falls-in-older-adults-with-cognitive-impairment-living-in-residential-care-prof-cog-a-feasibility-and-pilot-cluster-randomised-controlled-trial
#16
Julie Whitney, Stephen H D Jackson, Finbarr C Martin
BACKGROUND: Falls are common in people with dementia living in residential care. The ProF-Cog intervention was developed to address fall risk factors specific to this population. The aim of this study was to evaluate the safety, acceptability, and feasibility of the intervention and provide an estimate of its efficacy. METHODS: This was a cluster randomised controlled pilot study undertaken in care homes in London, UK. All permanent residents living in participating homes who were not terminally ill were invited to participate...
May 30, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28554835/transcriptome-profiling-of-the-macrobrachium-rosenbergii-lymphoid-organ-under-the-white-spot-syndrome-virus-challenge
#17
Jun Cao, Lei Wu, Min Jin, Tingting Li, Kaimin Hui, Qian Ren
Macrobrachium rosenbergii is a crustacean with economic importance, and adult prawns are generally thought to be tolerant to white spot syndrome virus (WSSV) infection. Although certain genes are known to respond to WSSV infection and lymphoid tissue is an important immune organ, the response of lymphoid organ to WSSV infection is unclear. Next-generation sequencing was employed in this study to determine the transcriptome differences between WSSV infection and mock lymphoid organs. A total of 44,606,694 and 40,384,856 clean reads were generated and assembled into 73,658 and 72,374 unigenes from the control sample and the WSSV infection sample, respectively...
May 26, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28549902/does-corrective-spine-surgery-improve-the-standing-balance-in-patients-with-adult-spinal-deformity
#18
Mitsuru Yagi, Hideaki Ohne, Shinjiro Kaneko, Masafumi Machida, Yoshiyuki Yato, Takashi Asazuma
BACKGROUND CONTEXT: The effect of corrective spine surgery on standing stability in adult spinal deformity (ASD) has not been fully documented. PURPOSE: To compare pre- and postoperative standing balance and posture in patients with ASD. STUDY DESIGN/SETTING: Prospective case series. PATIENT SAMPLE: Standing balance before and after corrective spine surgery was compared in 35 consecutive female patients with ASD (65...
May 23, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28549783/irinotecan-temozolomide-with-temsirolimus-or-dinutuximab-in-children-with-refractory-or-relapsed-neuroblastoma-cog-anbl1221-an-open-label-randomised-phase-2-trial
#19
Rajen Mody, Arlene Naranjo, Collin Van Ryn, Alice L Yu, Wendy B London, Barry L Shulkin, Marguerite T Parisi, Sabah-E-Noor Servaes, Mitchell B Diccianni, Paul M Sondel, Julia G Bender, John M Maris, Julie R Park, Rochelle Bagatell
BACKGROUND: Outcomes for children with relapsed and refractory neuroblastoma are dismal. The combination of irinotecan and temozolomide has activity in these patients, and its acceptable toxicity profile makes it an excellent backbone for study of new agents. We aimed to test the addition of temsirolimus or dinutuximab to irinotecan-temozolomide in patients with relapsed or refractory neuroblastoma. METHODS: For this open-label, randomised, phase 2 selection design trial of the Children's Oncology Group (COG; ANBL1221), patients had to have histological verification of neuroblastoma or ganglioneuroblastoma at diagnosis or have tumour cells in bone marrow with increased urinary catecholamine concentrations at diagnosis...
May 23, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28549722/deficient-prepulse-inhibition-in-schizophrenia-in-a-multi-site-cohort-internal-replication-and-extension
#20
Neal R Swerdlow, Gregory A Light, Michael L Thomas, Joyce Sprock, Monica E Calkins, Michael F Green, Tiffany A Greenwood, Raquel E Gur, Ruben C Gur, Laura C Lazzeroni, Keith H Nuechterlein, Allen D Radant, Larry J Seidman, Larry J Siever, Jeremy M Silverman, William S Stone, Catherine A Sugar, Debby W Tsuang, Ming T Tsuang, Bruce I Turetsky, David L Braff
BACKGROUND: The Consortium on the Genetics of Schizophrenia (COGS) collected case-control endophenotype and genetic information from 2457 patients and healthy subjects (HS) across 5 test sites over 3.5 years. Analysis of the first "wave" (W1) of 1400 subjects identified prepulse inhibition (PPI) deficits in patients vs. HS. Data from the second COGS "wave" (W2), and the combined W(1+2), were used to assess: 1) the replicability of PPI deficits in this design; 2) the impact of response criteria on PPI deficits; and 3) PPI in a large cohort of antipsychotic-free patients...
May 23, 2017: Schizophrenia Research
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