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https://www.readbyqxmd.com/read/28436391/prediction-of-conversion-to-alzheimer-s-disease-with-longitudinal-measures-and-time-to-event-data
#1
Kan Li, Wenyaw Chan, Rachelle S Doody, Joseph Quinn, Sheng Luo
BACKGROUND: Identifying predictors of conversion to Alzheimer's disease (AD) is critically important for AD prevention and targeted treatment. OBJECTIVE: To compare various clinical and biomarker trajectories for tracking progression and predicting conversion from amnestic mild cognitive impairment to probable AD. METHODS: Participants were from the ADNI-1 study. We assessed the ability of 33 longitudinal biomarkers to predict time to AD conversion, accounting for demographic and genetic factors...
April 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28436084/defining-significant-weight-loss-in-atypical-anorexia-nervosa
#2
K Jean Forney, Tiffany A Brown, Lauren A Holland-Carter, Grace A Kennedy, Pamela K Keel
OBJECTIVE: Atypical anorexia nervosa (AAN) is defined by the symptoms of anorexia nervosa in the presence of "significant weight loss" in individuals who are not underweight. Description of current weight in AAN has been limited, significant weight loss has not been defined, and the distinction between having AAN versus having weight suppression has not been examined. METHOD: Secondary analyses were conducted with data from an epidemiological study of women (n = 1,640) and men (n = 794)...
April 24, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28431529/hirbin-high-resolution-identification-of-differentially-abundant-functions-in-metagenomes
#3
Tobias Österlund, Viktor Jonsson, Erik Kristiansson
BACKGROUND: Gene-centric analysis of metagenomics data provides information about the biochemical functions present in a microbiome under a certain condition. The ability to identify significant differences in functions between metagenomes is dependent on accurate classification and quantification of the sequence reads (binning). However, biological effects acting on specific functions may be overlooked if the classes are too general. METHODS: Here we introduce High-Resolution Binning (HirBin), a new method for gene-centric analysis of metagenomes...
April 21, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28419192/efficacy-and-safety-of-a-novel-acetylcholinesterase-inhibitor-octohydroaminoacridine-in-mild-to-moderate-alzheimer-s-disease-a-phase-ii-multicenter-randomised-controlled-trial
#4
Shifu Xiao, Tao Wang, Xiuqiang Ma, Yingyi Qin, Xia Li, Zhongxin Zhao, Xueyuan Liu, Xiaoping Wang, Hengge Xie, Qinpu Jiang, Li Sun, Benyan Luo, Lan Shang, Weixian Chen, Yan Bai, Muni Tang, Maolin He, Lan Wu, Qilin Ma, Deren Hou, Jia He
Background: inhibition of acetylcholinesterase (AChE) has been a effective treatment for Alzheimer's disease (AD). Octohydroaminoacridine, a new AChE inhibitor, is a potential treatment for AD. Method: we conducted a multicenter, randomised, double blind, placebo-controlled, parallel-group Phase II clinical trial to investigate the effects of octohydroaminoacridine in patients with mild-to-moderate AD. Patients were randomised to receive placebo thrice daily, octohydroaminoacridine 1 mg/thrice daily (TID) (low-dose group), 2 mg/TID (middle-dose group) or 4 mg/TID (high-dose group)...
April 17, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28418065/vitamin-e-for-alzheimer-s-dementia-and-mild-cognitive-impairment
#5
REVIEW
Nicolas Farina, David Llewellyn, Mokhtar Gad El Kareem Nasr Isaac, Naji Tabet
BACKGROUND: Vitamin E occurs naturally in the diet. It has several biological activities, including functioning as an antioxidant to scavenge toxic free radicals. Evidence that free radicals may contribute to the pathological processes behind cognitive impairment has led to interest in the use of vitamin E supplements to treat mild cognitive impairment (MCI) and Alzheimer's disease (AD). This is an update of a Cochrane Review first published in 2000, and previously updated in 2006 and 2012...
April 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28413982/optimizing-adas-cog-worksheets-a-survey-of-clinical-trial-raters-perceptions
#6
Stephen M Meyer, Kristina A Bertzos, Magdalena Perez, Donald Connor, Kimberly Schafer, Sarah Walter
The Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) remains the most widely used test of longitudinal cognitive functioning in Alzheimer's disease (AD) clinical trials. Unlike most neuropsychological tests, the ADAS-Cog source documentation worksheets are not uniform across clinical trials, and vary by document layout, inclusion of administration and/or scoring instructions, and documentation of subtest scoring (e.g., recording correct versus incorrect scores), among other differences. Many ADAS-Cog test administrators (raters) participate in multiple AD trials and switching between different ADAS-Cog worksheets may increase the likelihood of administration and/or scoring mistakes that lessen the reliability of the instrument...
April 17, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28412460/characterization-of-transcriptome-in-the-indian-meal-moth-plodia-interpunctella-lepidoptera-pyralidae-and-gene-expression-analysis-during-developmental-stages
#7
Pei-An Tang, Hai-Jing Wu, Hao Xue, Xing-Rong Ju, Wei Song, Qi-Lin Zhang, Ming-Long Yuan
The Indian meal moth Plodia interpunctella (Lepidoptera: Pyralidae) is a worldwide pest that causes serious damage to stored foods. Although many efforts have been conducted on this species due to its economic importance, the study of genetic basis of development, behavior and insecticide resistance has been greatly hampered due to lack of genomic information. In this study, we used high throughput sequencing platform to perform a de novo transcriptome assembly and tag-based digital gene expression profiling (DGE) analyses across four different developmental stages of P...
April 13, 2017: Gene
https://www.readbyqxmd.com/read/28411445/comparison-of-the-classifier-oriented-gait-score-and-the-gait-profile-score-based-on-imitated-gait-impairments
#8
Christian Josef, Kröll Josef, Schwameder Hermann
Common summary measures of gait quality such as the Gait Profile Score (GPS) are based on the principle of measuring a distance from the mean pattern of a healthy reference group in a gait pattern vector space. The recently introduced Classifier Oriented Gait Score (COGS) is a pathology specific score that measures this distance in a unique direction, which is indicated by a linear classifier. This approach has potentially improved the discriminatory power to detect subtle changes in gait patterns but does not incorporate a profile of interpretable sub-scores like the GPS...
April 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28411282/genomic-architecture-and-treatment-outcome-in-pediatric-acute-myeloid-leukemia-a-children-s-oncology-group-report
#9
Marijana Vujkovic, Edward F Attiyeh, Rhonda E Ries, Elizabeth K Goodman, Yang Ding, Marko Kavcic, Todd A Alonzo, Yi-Cheng Wang, Robert B Gerbing, Lillian Sung, Betsy Hirsch, Susana Raimondi, Alan S Gamis, Soheil Meshinchi, Richard Aplenc
Childhood acute myeloid leukemia (AML) is frequently characterized by chromosomal instability. Approximately 50% of patients have disease relapse, and novel prognostic markers are needed to improve risk stratification. We performed genome-wide genotyping in 446 pediatric patients with de novo AML enrolled on Children's Oncology Group (COG) studies, AAML0531 (NCT01407757), AAML03P1 (NCT00070174), and CCG2961 (NCT00003790). Affymetrix and Illumina Omni 2.5 platforms were used to evaluate copy number alterations (CNAs) and determine their associations with treatment outcome...
April 14, 2017: Blood
https://www.readbyqxmd.com/read/28409115/a-metagenomic-approach-to-decipher-the-indigenous-microbial-communities-of-arsenic-contaminated-groundwater-of-assam
#10
Saurav Das, Sudipta Sankar Bora, R N S Yadav, Madhumita Barooah
Metagenomic approach was used to understand the structural and functional diversity present in arsenic contaminated groundwater of the Ganges Brahmaputra Delta aquifer system. A metagene dataset (coded as TTGW1) of 89,171 sequences (totaling 125,449,864 base pairs) with an average length of 1406 bps was annotated. About 74,478 sequences containing 101,948 predicted protein coding regions passed the quality control. Taxonomical classification revealed abundance of bacteria that accounted for 98.3% of the microbial population of the metagenome...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28407805/revelation-of-mrnas-and-proteins-in-porcine-milk-exosomes-by-transcriptomic-and-proteomic-analysis
#11
Ting Chen, Qian-Yun Xi, Jia-Jie Sun, Rui-Song Ye, Xiao Cheng, Rui-Ping Sun, Song-Bo Wang, Gang Shu, Li-Na Wang, Xiao-Tong Zhu, Qing-Yan Jiang, Yong-Liang Zhang
BACKGROUND: Milk is a complex liquid that provides nutrition to newborns. Recent reports demonstrated that milk is enriched in maternal-derived exosomes that are involved in fetal physiological and pathological conditions by transmission of exosomal mRNAs, miRNAs and proteins. Until now, there is no such research relevant to exosomal mRNAs and proteins in porcine milk, therefore, we have attempted to investigate porcine milk exosomal mRNAs and proteins using RNA-sequencing and proteomic analysis...
April 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28402165/statistical-properties-of-continuous-composite-scales-and-implications-for-drug-development
#12
Hong Liu-Seifert, Scott Andersen, Michael Case, JonDavid Sparks, Karen C Holdridge, Alette M Wessels, Suzanne Hendrix, Paul Aisen, Eric Siemers
Little research has been conducted on the statistical properties of composite measures comprising linear combinations of continuous component scales. We assessed the quantitative relationship between the composites and their individual components regarding their abilities to detect treatment effects. In particular, we developed the mathematical derivation of the treatment effect size of a continuous composite in relation to the treatment effect sizes of its components and proved multiple properties of the composite...
April 12, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28391003/surgery-alone-is-sufficient-therapy-for-children-and-adolescents-with-low-risk-synovial-sarcoma-a-joint-analysis-from-the-european-paediatric-soft-tissue-sarcoma-study-group-and-the-children-s-oncology-group
#13
Andrea Ferrari, Yueh-Yun Chi, Gian Luca De Salvo, Daniel Orbach, Bernadette Brennan, R Lor Randall, M Beth McCarville, Jennifer O Black, Rita Alaggio, Douglas S Hawkins, Gianni Bisogno, Sheri L Spunt
BACKGROUND: Multimodal risk-adapted treatment is used in paediatric protocols for synovial sarcoma (SS). Retrospective analyses suggest that low-risk SS patients can be safely treated with surgery alone, but no prospective studies have confirmed the safety of this approach. This analysis pooled data from the two prospective clinical trials to assess outcomes in SS patients treated with a surgery-only approach and to identify predictors of treatment failure. METHODS: Patients with localised SS enrolled on the European paediatric Soft tissue sarcoma Study Group (EpSSG) NRSTS2005 and on the Children Oncology Group (COG) ARST0332 trials, treated with surgery alone were eligible for this analysis...
April 6, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28389462/improved-outcomes-for-myeloid-leukemia-of-down-syndrome-a-report-from-the-children-s-oncology-group-aaml0431-trial
#14
Jeffrey W Taub, Jason N Berman, Johann K Hitzler, April D Sorrell, Norman J Lacayo, Kelley Mast, David Head, Susana Raimondi, Betsy Hirsch, Yubin Ge, Robert B Gerbing, Yi-Cheng Wang, Todd A Alonzo, Dario Campana, Elaine Coustan-Smith, Prasad Mathew, Alan S Gamis
Patients with myeloid leukemia of Down syndrome (ML-DS) have a favorable event-free survival (EFS), but experience significant treatment-related morbidity and mortality. ML-DS blast cells ex vivo have increased sensitivity to cytarabine (araC) and daunorubicin, suggesting that optimizing drug dosing may improve outcomes while reducing toxicity. The Children's Oncology Group (COG) AAML0431 trial consisted of 4 cycles of Induction and 2 cycles of Intensification therapy based on the treatment schema of the previous COG A2971 trial with several modifications...
April 7, 2017: Blood
https://www.readbyqxmd.com/read/28387664/efficacy-of-hearing-aids-on-the-cognitive-status-of-patients-with-alzheimer-s-disease-and-hearing-loss-a-multicenter-controlled-randomized-trial
#15
Marie-France Nguyen, Marc Bonnefoy, Arnaud Adrait, Marine Gueugnon, Charles Petitot, Lionel Collet, Adeline Roux, Xavier Perrot
BACKGROUND/OBJECTIVE: This study evaluated the cognitive benefit of hearing aids (HA) in older patients with Alzheimer's disease (AD) and hearing loss (HL) after a 6- and 12-month period of utilization. METHODS: A multicenter double-blind randomized placebo-controlled trial was conducted in patients aged more than 65 years. A group was equipped with active HA for 6 months (active group) and a second group had placebo HA for 6 months (placebo group) followed by a secondary activation phase for a further 6 months (semi crossover procedure)...
April 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28386247/gamola2-a-comprehensive-software-package-for-the-annotation-and-curation-of-draft-and-complete-microbial-genomes
#16
Eric Altermann, Jingli Lu, Alan McCulloch
Expert curated annotation remains one of the critical steps in achieving a reliable biological relevant annotation. Here we announce the release of GAMOLA2, a user friendly and comprehensive software package to process, annotate and curate draft and complete bacterial, archaeal, and viral genomes. GAMOLA2 represents a wrapping tool to combine gene model determination, functional Blast, COG, Pfam, and TIGRfam analyses with structural predictions including detection of tRNAs, rRNA genes, non-coding RNAs, signal protein cleavage sites, transmembrane helices, CRISPR repeats and vector sequence contaminations...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28376230/target-and-agent-prioritization-for-the-children-s-oncology-group-national-cancer-institute-pediatric-match-trial
#17
Carl E Allen, Theodore W Laetsch, Rajen Mody, Meredith S Irwin, Megan S Lim, Peter C Adamson, Nita L Seibel, D Williams Parsons, Y Jae Cho, Katherine Janeway
Over the past decades, outcomes for children with cancer have improved dramatically through serial clinical trials based in large measure on dose intensification of cytotoxic chemotherapy for children with high-risk malignancies. Progress made through such dose intensification, in general, is no longer yielding further improvements in outcome. With the revolution in sequencing technologies and rapid development of drugs that block specific proteins and pathways, there is now an opportunity to improve outcomes for pediatric cancer patients through mutation-based targeted therapeutic strategies...
May 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376127/the-doc-screen-feasible-and-valid-screening-for-depression-obstructive-sleep-apnea-osa-and-cognitive-impairment-in-stroke-prevention-clinics
#18
Richard H Swartz, Megan L Cayley, Krista L Lanctôt, Brian J Murray, Ashley Cohen, Kevin E Thorpe, Michelle N Sicard, Karen Lien, Demetrios J Sahlas, Nathan Herrmann
BACKGROUND: Post-stroke Depression, Obstructive sleep apnea (OSA) and Cognitive impairment ("DOC") are associated with greater mortality, worse recovery and poorer quality of life. Best practice recommendations endorse routine screening for each condition; yet, all are under-assessed, diagnosed and treated. We seek to determine the feasibility and validity of an integrated tool ("DOC" screen) to identify stroke clinic patients at high-risk of depression, OSA, and cognitive impairment...
2017: PloS One
https://www.readbyqxmd.com/read/28355134/the-interactome-of-the-copper-transporter-atp7a-belongs-to-a-network-of-neurodevelopmental-and-neurodegeneration-factors
#19
Heather S Comstra, Jacob McArthy, Samantha Rudin-Rush, Cortnie Hartwig, Avanti Gokhale, Stephanie A Zlatic, Jessica B Blackburn, Erica Werner, Michael Petris, Priya D'Souza, Parinya Panuwet, Dana Boyd Barr, Vladimir Lupashin, Alysia Vrailas-Mortimer, Victor Faundez
Genetic and environmental factors, such as metals, interact to determine neurological traits. We reasoned that interactomes of molecules handling metals in neurons should include novel metal homeostasis pathways. We focused on copper and its transporter ATP7A because ATP7A null mutations cause neurodegeneration. We performed ATP7A immunoaffinity chromatography and identified 541 proteins co-isolating with ATP7A. The ATP7A interactome concentrated gene products implicated in neurodegeneration and neurodevelopmental disorders, including subunits of the Golgi-localized conserved oligomeric Golgi (COG) complex...
March 29, 2017: ELife
https://www.readbyqxmd.com/read/28353129/management-of-hepatoblastoma-icmr-consensus-document
#20
REVIEW
Sandeep Agarwala, Alisha Gupta, Deepak Bansal, Tushar Vora, Maya Prasad, Brijesh Arora, Gauri Kapoor, Girish Chinnaswamy, Venkatraman Radhakrishnan, Siddharth Laskar, Tanvir Kaur, Rupinder Singh Dhaliwal, G K Rath, Sameer Bakhshi
Dramatic advancement has been made in the management of children with hepatoblastoma (HB) over the past 3 decades owing to the improvement in diagnostic imaging, new chemotherapeutic agents, better surgical care and availability of liver transplantation. These advances are the end results of contributions from 4 major study groups across the globe including International Society of Pediatric Oncology - Liver Tumor Strategy Group (SIOPEL), Children's Oncology Group (COG), German Pediatric Hematology Oncology Group (GPOH) and Japanese Pediatric Liver Tumor Study Group (JPLT)...
March 29, 2017: Indian Journal of Pediatrics
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