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https://www.readbyqxmd.com/read/27902840/team-based-interprofessional-competency-training-for-dementia-screening-and-management
#1
Zaldy S Tan, JoAnn Damron-Rodriguez, Mary Cadogan, Daphna Gans, Rachel M Price, Sharon S Merkin, Lee Jennings, Heather Schickedanz, Sam Shimomura, Dan Osterweil, Joshua Chodosh
As many as 50% of people satisfying diagnostic criteria for dementia are undiagnosed. A team-based training program for dementia screening and management was developed targeting four professions (medicine, nursing, pharmacy, social work) whose scope of practice involves dementia care. An interprofessional group of 10 faculty members was trained to facilitate four interactive competency stations on dementia screening, differential diagnoses, dementia management and team care planning, and screening for and managing caregiver stress...
November 30, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27895627/distribution-and-classification-of-serine-%C3%AE-lactamases-in-brazilian-hospital-sewage-and-other-environmental-metagenomes-deposited-in-public-databases
#2
Adriana M Fróes, Fábio F da Mota, Rafael R C Cuadrat, Alberto M R Dávila
β-lactam is the most used antibiotic class in the clinical area and it acts on blocking the bacteria cell wall synthesis, causing cell death. However, some bacteria have evolved resistance to these antibiotics mainly due the production of enzymes known as β-lactamases. Hospital sewage is an important source of dispersion of multidrug-resistant bacteria in rivers and oceans. In this work, we used next-generation DNA sequencing to explore the diversity and dissemination of serine β-lactamases in two hospital sewage from Rio de Janeiro, Brazil (South Zone, SZ and North Zone, NZ), presenting different profiles, and to compare them with public environmental data available...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27876778/differential-fecal-microbiota-are-retained-in-broiler-chicken-lines-divergently-selected-for-fatness-traits
#3
Qiangchuan Hou, Lai-Yu Kwok, Yi Zheng, Lifeng Wang, Zhuang Guo, Jiachao Zhang, Weiqiang Huang, Yuxiang Wang, Li Leng, Hui Li, Heping Zhang
Our study combined 16S rRNA-pyrosequencing and whole genome sequencing to analyze the fecal metagenomes of the divergently selected lean (LL) and fat (FL) line chickens. Significant structural differences existed in both the phylogenic and functional metagenomes between the two chicken lines. At phylum level, the FL group had significantly less Bacteroidetes. At genus level, fourteen genera of different relative abundance were identified, with some known short-chain fatty acid producers (including Subdoligranulum, Butyricicoccus, Eubacterium, Bacteroides, Blautia) and a potentially pathogenic genus (Enterococcus)...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872267/endophenotypes-epigenetics-polygenicity-and-more-irv-gottesman-s-dynamic-legacy
#4
David L Braff, Carol A Tamminga
First, we describe the hallmark contributions of Irv Gottesman's pioneering scholarship for schizophrenia research including concepts of polygenicity, gene × environment interactions, epigenetics and the endophenotype concept. Gottesman and colleagues' twin studies showed that genes, not social factors, mediate schizophrenia risk. He then showed that schizophrenia is highly polygenic. Next, he introduced the concept of epigenetics into schizophrenia research. Gottesman then introduced the quantitative endophenotype concept...
November 21, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27870572/impact-of-extent-of-resection-on-local-control-and-survival-in-patients-from-the-cog-a3973-study-with-high-risk-neuroblastoma
#5
Daniel von Allmen, Andrew M Davidoff, Wendy B London, Collin Van Ryn, Daphne A Haas-Kogan, Susan G Kreissman, Geetika Khanna, Nancy Rosen, Julie R Park, Michael P La Quaglia
Purpose This analysis of patients in the Children's Oncology Group A3973 study evaluated the impact of extent of primary tumor resection on local progression and survival and assessed concordance between clinical and central imaging review-based assessments of resection extent. Patients and Methods The analytic cohort (n = 220) included patients who had both central surgery review and resection of the primary tumor site. For this analysis, resection categories of < 90% and ≥ 90% were used, with data on resection extent derived from operating surgeons' assessments (all patients), as well as blinded central imaging review of computed tomography scans for a subset of 84 patients; assessment results were compared for concordance...
November 21, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27863809/efficacy-and-safety-of-tau-aggregation-inhibitor-therapy-in-patients-with-mild-or-moderate-alzheimer-s-disease-a-randomised-controlled-double-blind-parallel-arm-phase-3-trial
#6
Serge Gauthier, Howard H Feldman, Lon S Schneider, Gordon K Wilcock, Giovanni B Frisoni, Jiri H Hardlund, Hans J Moebius, Peter Bentham, Karin A Kook, Damon J Wischik, Bjoern O Schelter, Charles S Davis, Roger T Staff, Luc Bracoud, Kohkan Shamsi, John M D Storey, Charles R Harrington, Claude M Wischik
BACKGROUND: Leuco-methylthioninium bis(hydromethanesulfonate; LMTM), a stable reduced form of the methylthioninium moiety, acts as a selective inhibitor of tau protein aggregation both in vitro and in transgenic mouse models. Methylthioninium chloride has previously shown potential efficacy as monotherapy in patients with Alzheimer's disease. We aimed to determine whether LMTM was safe and effective in modifying disease progression in patients with mild to moderate Alzheimer's disease...
November 15, 2016: Lancet
https://www.readbyqxmd.com/read/27856344/anxiety-provokes-balance-deficits-that-are-selectively-dopa-responsive-in-parkinson-s-disease
#7
Kaylena A Ehgoetz Martens, Shannon C Lefaivre, Eric N Beck, Rebecca Chow, Frederico Pieruccini-Faria, Colin G Ellard, Quincy J Almeida
Previous research has suggested that balance impairments may be linked to anxiety in PD, yet there is little empirical evidence to support this link in PD. This study aimed to evaluate the influence of anxiety on balance, and also examine whether dopaminergic treatment modulates the influence of anxiety on balance. Forty-two participants (10 high anxious PD [HA-PD]; 11 low anxious PD [LA-PD], 21 controls [HC]) performed 10 quiet standing trials on a force platform in two virtual environments: LOW threat; on a plank located on the ground; HIGH threat; on an elevated plank...
November 14, 2016: Neuroscience
https://www.readbyqxmd.com/read/27854044/cochrane-review-brief-mini-cog-for-the-diagnosis-of-alzheimer%C3%A2-s-disease-dementia-and-other-dementias-within-a-community-setting
#8
Christine Neville
No abstract text is available yet for this article.
December 21, 2015: Online Journal of Issues in Nursing
https://www.readbyqxmd.com/read/27847677/the-use-of-moca-and-other-cognitive-tests-in-evaluation-of-cognitive-impairment-in-elderly-patients-undergoing-arthroplasty
#9
Jukka Puustinen, Liisa Luostarinen, Markku Luostarinen, Veijo Pulliainen, Heini Huhtala, Marjo Soini, Jaana Suhonen
OBJECTIVE: To examine the prevalence and effect of cognitive impairment on treatment outcomes in elderly patients undergoing arthroplasty and to describe the feasibility of cognitive tests. MATERIALS AND METHODS: The participants were 52 patients with a mean age of 78 years 11 months (SD: 3.3), waiting for primary arthroplasty. We translated Montreal Cognitive Assessment (MoCA) into Finnish and compared it with Mini-Mental State Examination (MMSE), Mini-Cog, and clock-drawing tests prior to and 3 months after the surgery...
December 2016: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/27833878/the-epitympanum-revisited-endoscopic-anatomy
#10
Muaaz Tarabichi, Daniele Marchioni, Mustafa Kapadia
In contrast to other means of studying the epitymapnum, the endoscope allows unparallel access without disruption of anatomy. The aim of this study is to delineate the anatomy of the epitympanum through transcanal endoscopy. Systematic dissection of anatomic specimens. We performed systematic endoscopic dissection of 20 ears in 10 fresh frozen anatomical specimens. A detailed flow sheet was filled up documenting the status of the lateral attic folds, the tensor fold, the cog and the tensor folds, the supratubal recess, and the patency of the anterior and posterior isthmus...
December 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27823981/repetitive-transcranial-magnetic-stimulation-improves-cognitive-function-of-alzheimer-s-disease-patients
#11
Junwu Zhao, Zhenguang Li, Yannan Cong, Jinbiao Zhang, Ming Tan, Haixia Zhang, Na Geng, Mengfan Li, Wenwen Yu, Peiyan Shan
Repetitive transcranial magnetic stimulation (rTMS) acts as a kind of widely-applied and non-invasive method in the intervention of some neurological disorders. This prospective, randomized, double-blind, placebo-controlled trial investigates the effect of rTMS on 30 cases of Alzheimer's disease (AD) participants, who were classified into mild and moderate groups. Neuropsychological tests were carried out using the AD Assessment Scale-cognitive subscale (ADAS-cog), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and World Health Organization University of California-Los Angeles, Auditory Verbal Learning Test (WHO-UCLA AVLT) before, immediately after, and 6 weeks after the intervention...
November 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27820126/identification-of-high-risk-cryptic-crlf2-rearrangements-in-b-cell-acute-lymphoblastic-leukemia-utilizing-an-fgfr3-igh-dual-color-dual-fusion-dna-probe-set
#12
Adam J Robin, Jess F Peterson, John W Grignon, Gabriela Gheorghe, Michael J Burke, Peter vanTuinen
B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood malignancy with gene rearrangements involving the IGH locus occurring in ∼5% of cases. Fluorescence in situ hybridization (FISH) probes targeting the IGH locus are not included in the standard children's oncology group (COG) fluorescence in situ hybridization panel. At our institute, we incorporated the use of FGFR3/IGH dual-color dual-fusion DNA probes for confirmation of aneuploidy 4 and 14 in diagnostic B-ALL specimens. Subsequently we have identified 4 B-ALL cases with cryptic CRLF2-IGH translocations that would otherwise have gone undetected...
November 4, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27819317/transcriptomic-analysis-on-the-formation-of-the-viable-putative-non-culturable-state-of-beer-spoilage-lactobacillus-acetotolerans
#13
Junyan Liu, Yang Deng, Brian M Peters, Lin Li, Bing Li, Lequn Chen, Zhenbo Xu, Mark E Shirtliff
Lactic acid bacteria (LAB) are the most common beer-spoilage bacteria regardless of beer type, and thus pose significant problems for the brewery industry. The aim of this study was to investigate the genetic mechanisms involved in the ability of the hard-to-culture beer-spoilage bacterium Lactobacillus acetotolerans to enter into the viable putative non-culturable (VPNC) state. A genome-wide transcriptional analysis of beer-spoilage L. acetotolerans strains BM-LA14526, BM-LA14527, and BM-LA14528 under normal, mid-term and VPNC states were performed using RNA-sequencing (RNA-seq) and further bioinformatics analyses...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27806133/transcriptome-analysis-and-comparison-of-marmota-monax-and-marmota-himalayana
#14
Yanan Liu, Baoju Wang, Lu Wang, Vikash Vikash, Qin Wang, Michael Roggendorf, Mengji Lu, Dongliang Yang, Jia Liu
The Eastern woodchuck (Marmota monax) is a classical animal model for studying hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) in humans. Recently, we found that Marmota himalayana, an Asian animal species closely related to Marmota monax, is susceptible to woodchuck hepatitis virus (WHV) infection and can be used as a new mammalian model for HBV infection. However, the lack of genomic sequence information of both Marmota models strongly limited their application breadth and depth. To address this major obstacle of the Marmota models, we utilized Illumina RNA-Seq technology to sequence the cDNA libraries of liver and spleen samples of two Marmota monax and four Marmota himalayana...
2016: PloS One
https://www.readbyqxmd.com/read/27800124/draft-genome-sequence-of-streptomyces-sp-tp-a0867-an-alchivemycin-producer
#15
Hisayuki Komaki, Natsuko Ichikawa, Akio Oguchi, Moriyuki Hamada, Enjuro Harunari, Shinya Kodani, Nobuyuki Fujita, Yasuhiro Igarashi
Streptomyces sp. TP-A0867 (=NBRC 109436) produces structurally complex polyketides designated alchivemycins A and B. Here, we report the draft genome sequence of this strain together with features of the organism and assembly, annotation, and analysis of the genome sequence. The 9.9 Mb genome of Streptomyces sp. TP-A0867 encodes 8,385 putative ORFs, of which 7,232 were assigned with COG categories. We successfully identified a hybrid polyketide synthase (PKS)/ nonribosomal peptide synthetase (NRPS) gene cluster that could be responsible for alchivemycin biosynthesis, and propose the biosynthetic pathway...
2016: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/27795808/draft-genome-sequence-of-micromonospora-sp-dsw705-and-distribution-of-biosynthetic-gene-clusters-for-depsipeptides-bearing-4-amino-2-4-pentadienoate-in-actinomycetes
#16
Hisayuki Komaki, Natsuko Ichikawa, Akira Hosoyama, Moriyuki Hamada, Enjuro Harunari, Arisa Ishikawa, Yasuhiro Igarashi
Here, we report the draft genome sequence of Micromonospora sp. DSW705 (=NBRC 110037), a producer of antitumor cyclic depsipeptides rakicidins A and B, together with the features of this strain and generation, annotation, and analysis of the genome sequence. The 6.8 Mb genome of Micromonospora sp. DSW705 encodes 6,219 putative ORFs, of which 4,846 are assigned with COG categories. The genome harbors at least three type I polyketide synthase (PKS) gene clusters, one nonribosomal peptide synthetase (NRPS) gene clusters, and three hybrid PKS/NRPS gene clusters...
2016: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/27793183/evolving-methods-to-combine-cognitive-and-physical-training-for-individuals-with-mild-cognitive-impairment-study-protocol-for-a-randomized-controlled-study
#17
Ya-Yun Lee, Ching-Yi Wu, Ching-Hung Teng, Wen-Chuin Hsu, Ku-Chou Chang, Poyu Chen
BACKGROUND: Nonpharmacologic interventions, such as cognitive training or physical exercise, are effective in improving cognitive functions for older adults with mild cognitive impairment (MCI). Some researchers have proposed that combining physical exercise with cognitive training may augment the benefits of cognition. However, strong evidence is lacking regarding whether a combined therapy is superior to a single type of training for older adults with MCI. Moreover, which combination approach - combining physical exercise with cognitive training sequentially or simultaneously - is more advantageous for cognitive improvement is not yet clear...
October 28, 2016: Trials
https://www.readbyqxmd.com/read/27789703/prokaryotic-virus-orthologous-groups-pvogs-a-resource-for-comparative-genomics-and-protein-family-annotation
#18
Ana Laura Grazziotin, Eugene V Koonin, David M Kristensen
Viruses are the most abundant and diverse biological entities on earth, and while most of this diversity remains completely unexplored, advances in genome sequencing have provided unprecedented glimpses into the virosphere. The Prokaryotic Virus Orthologous Groups (pVOGs, formerly called Phage Orthologous Groups, POGs) resource has aided in this task over the past decade by using automated methods to keep pace with the rapid increase in genomic data. The uses of pVOGs include functional annotation of viral proteins, identification of genes and viruses in uncharacterized DNA samples, phylogenetic analysis, large-scale comparative genomics projects, and more...
October 26, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27787870/characterizing-semaphorin-mediated-effects-on-sensory-and-motor-axon-pathfinding-and-connectivity-during-embryonic-development
#19
Rosa Eva Huettl, Andrea B Huber
How are precise connectivity to peripheral targets and corresponding sensory-motor networks established during developmental innervation of the vertebrate extremities? The formation of functional sensory-motor circuits requires highly appropriate temporal and spatial regulation of axon growth which is achieved through the combination of different molecular mechanisms such as communication between heterotypic fiber systems, axon-environment, or axon-glia interactions that ensure proper fasciculation and accurate pathfinding to distal targets...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27786406/childhood-hodgkin-international-prognostic-score-chips-predicts-event-free-survival-in-hodgkin-lymphoma-a-report-from-the-children-s-oncology-group
#20
Cindy L Schwartz, Lu Chen, Kathleen McCarten, Suzanne Wolden, Louis S Constine, Robert E Hutchison, Pedro A de Alarcon, Frank G Keller, Kara M Kelly, Tanya A Trippet, Stephan D Voss, Debra L Friedman
BACKGROUND: Early response to initial chemotherapy in Hodgkin lymphoma (HL) measured by computed tomography (CT) and/or positron emission tomography (PET) after two to three cycles of chemotherapy may inform therapeutic decisions. Risk stratification at diagnosis could, however, allow earlier and potentially more efficacious treatment modifications. PATIENTS AND METHODS: We developed a predictive model for event-free survival (EFS) in pediatric/adolescent HL using clinical data known at diagnosis from 1103 intermediate-risk HL patients treated on Children's Oncology Group protocol AHOD0031 with doxorubicin, bleomycin, vincristine, etoposide, prednisone, cyclophosphamide (ABVE-PC) chemotherapy and radiation...
October 27, 2016: Pediatric Blood & Cancer
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