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https://www.readbyqxmd.com/read/28079820/hepatoblastoma-in-an-11-year-old-case-report-and-a-review-of-the-literature
#1
Irina B Pateva, Rachel A Egler, Duncan S Stearns
RATIONALE: Hepatoblastoma is a rare malignancy. Approximately 100 cases are diagnosed yearly in the United States. The highest incidence occurs in infants and in children younger than 5 years. Cases involving patients older than 5 years are very rare. We describe the case of a patient who was diagnosed with hepatoblastoma at an atypical age of presentation for this type of malignancy. We also performed Ovid MEDLINE search for hepatoblastoma and epidemiology reports occurring in children between the ages of 5 and 18 years...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28075038/effect-of-aerobic-exercise-on-cancer-associated-cognitive-impairment-a-proof-of-concept-rct
#2
K L Campbell, J W Y Kam, S E Neil-Sztramko, T Liu Ambrose, T C Handy, H Lim, S Hayden, L Hsu, A A Kirkham, C C Gotay, D C McKenzie, L A Boyd
BACKGROUND: Change in cognitive ability is a commonly reported side effect by breast cancer survivors (BCS). The underlying etiology of cognitive complaints is unclear and to date there is limited evidence for effective intervention strategies. Exercise has been shown to improve cognitive function in older adults and animal models treated with chemotherapy. This proof-of-concept randomized controlled trial (RCT) tested the effect of aerobic exercise versus usual lifestyle on cognitive function in postmenopausal BCS...
January 11, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28068831/the-diagnostic-accuracy-of-the-kimberley-indigenous-cognitive-assessment-kica-tool-a-systematic-review
#3
Suzanne M Dyer, Kate Laver, Margeret Friel, Craig Whitehead, Maria Crotty
OBJECTIVES: The objective of this study was to conduct a systematic review of evidence for the accuracy of the Kimberley Indigenous Cognitive Assessment (KICA) tool in supporting the diagnosis of dementia in Indigenous Australian populations. METHODS: Cross-sectional diagnostic accuracy studies of the KICA with an appropriate reference standard published to November 2015 were included. Comparison to an alternative cognitive assessment tool was required in non-remote populations...
January 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28056803/de-novo-transcriptome-and-expression-profile-analyses-of-the-asian-corn-borer-ostrinia-furnacalis-reveals-relevant-flubendiamide-response-genes
#4
Li Cui, Changhui Rui, Daibin Yang, Zhenying Wang, Huizhu Yuan
BACKGROUND: The Asian corn borer (ACB), Ostrinia furnacalis (Guenée), has become the most damaging insect pest of corn in Asia. However, the lack of genome or transcriptome information heavily hinders our further understanding of ACB in every aspect at a molecular level and on a genome-wide scale. Here, we used the Ion Torrent Personal Genome Machine (PGM) Sequencer to explore the ACB transcriptome and to identify relevant genes in response to flubendiamide, showing high selective activity against ACB...
January 5, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28056205/evaluation-of-a-web-based-cognitive-rehabilitation-program-in-cancer-survivors-reporting-cognitive-symptoms-after-chemotherapy
#5
Victoria J Bray, Haryana M Dhillon, Melanie L Bell, Michael Kabourakis, Mallorie H Fiero, Desmond Yip, Frances Boyle, Melanie A Price, Janette L Vardy
Purpose Cognitive impairment is reported frequently by cancer survivors. There are no proven treatments. We evaluated a cognitive rehabilitation program (Insight) and compared it with standard care in cancer survivors self-reporting cognitive symptoms. Patients and Methods We recruited adult cancer survivors with a primary malignancy (excluding central nervous system malignancies) who had completed three or more cycles of adjuvant chemotherapy in the previous 6 to 60 months and reported persistent cognitive symptoms...
January 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28053843/influence-of-obesity-on-postural-stability-in-young-adults
#6
Sung Min Son
OBJECTIVES: The purpose of this study was to determine whether obesity is associated with less postural stability in young adults, and whether it is influenced by anterior pelvic tilt angle and sensory dysfunction. METHODS: Center of gravity (COG) velocity and total sway distance with eyes open or eyes closed on firm or foam floors were determined in 12 obese individuals and 12 individuals with normal weight. RESULTS: On firm and foam floors with eyes closed, center of gravity velocity and total sway distance were significantly greater in the obese group than in the normal-weight group...
December 2016: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28053163/atgc-database-and-atgc-cogs-an-updated-resource-for-micro-and-macro-evolutionary-studies-of-prokaryotic-genomes-and-protein-family-annotation
#7
David M Kristensen, Yuri I Wolf, Eugene V Koonin
The Alignable Tight Genomic Clusters (ATGCs) database is a collection of closely related bacterial and archaeal genomes that provides several tools to aid research into evolutionary processes in the microbial world. Each ATGC is a taxonomy-independent cluster of 2 or more completely sequenced genomes that meet the objective criteria of a high degree of local gene order (synteny) and a small number of synonymous substitutions in the protein-coding genes. As such, each ATGC is suited for analysis of microevolutionary variations within a cohesive group of organisms (e...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28050585/dataset-of-the-proteome-of-purified-outer-membrane-vesicles-from-the-human-pathogen-aggregatibacter-actinomycetemcomintans
#8
Thomas Kieselbach, Jan Oscarsson
The Gram-negative bacterium Aggregatibacter actinomycetemcomitans is an oral and systemic pathogen, which is linked to aggressive forms of periodontitis and can be associated with endocarditis. The outer membrane vesicles (OMVs) of this species contain effector proteins such as cytolethal distending toxin (CDT) and leukotoxin (LtxA), which they can deliver into human host cells. The OMVs can also activate innate immunity through NOD1- and NOD2-active pathogen-associated molecular patterns. This dataset provides a proteome of highly purified OMVs from A...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28046012/transcriptome-analysis-of-taxillusi-chinensis-dc-danser-seeds-in-response-to-water-loss
#9
Shugen Wei, Xiaojun Ma, Limei Pan, Jianhua Miao, Jine Fu, Longhua Bai, Zhonglian Zhang, Yanhong Guan, Changming Mo, Hao Huang, Maoshan Chen
BACKGROUND: Taxillus chinensis (DC.) Danser, the official species of parasitic loranthus that grows by parasitizing other plants, is used in various traditional Chinese medicine prescriptions. ABA-dependent and ABA-independent pathways are two major pathways in response to drought stress for plants and some genes have been reported to play a key role during the dehydration including dehydration-responsive protein RD22, late embryogenesis abundant (LEA) proteins, and various transcription factors (TFs) like MYB and WRKY...
2017: PloS One
https://www.readbyqxmd.com/read/28045051/randomized-trial-on-the-effects-of-a-combined-physical-cognitive-training-in-aged-mci-subjects-the-train-the-brain-study
#10
(no author information available yet)
Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039287/vascular-biomarkers-to-predict-response-to-exercise-in-alzheimer-s-disease-the-study-protocol
#11
Danni Li, Robin Thomas, Michael Y Tsai, Ling Li, David M Vock, Susan Greimel, Fang Yu
INTRODUCTION: Exercise interventions are a promising treatment for improving cognition in persons with Alzheimer's disease. This is similar to Alzheimer's disease pharmacotherapies in which only 18-48% of treated patients demonstrate improvement in cognition. Aerobic exercise interventions positively affect brain structure and function through biologically sound pathways. However, an under-studied mechanism of aerobic exercise's effects is n-3 fatty acids in plasma. The objective of this pilot study is to inform a future large-scale study to develop n-3 fatty acids-based prediction of cognitive responses to aerobic exercise treatment in Alzheimer's disease...
December 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/28035408/identification-of-antibiotic-resistance-genes-in-the-multidrug-resistant-acinetobacter-baumannii-strain-mdr-shh02-using-whole-genome-sequencing
#12
Hualiang Wang, Jinghua Wang, Peijuan Yu, Ping Ge, Yanqun Jiang, Rong Xu, Rong Chen, Xuejie Liu
This study aimed to investigate antibiotic resistance genes in the multidrug-resistant (MDR) Acinetobacter baumannii (A. baumanii) strain, MDR-SHH02, using whole‑genome sequencing (WGS). The antibiotic resistance of MDR-SHH02 isolated from a patient with breast cancer to 19 types of antibiotics was determined using the Kirby‑Bauer method. WGS of MDR-SHH02 was then performed. Following quality control and transcriptome assembly, functional annotation of genes was conducted, and the phylogenetic tree of MDR-SHH02, along with another 5 A...
December 30, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28029304/cognitive-complaints-in-survivors-of-breast-cancer-after-chemotherapy-compared-with-age-matched-controls-an-analysis-from-a-nationwide-multicenter-prospective-longitudinal-study
#13
Michelle C Janelsins, Charles E Heckler, Luke J Peppone, Charles Kamen, Karen M Mustian, Supriya G Mohile, Allison Magnuson, Ian R Kleckner, Joseph J Guido, Kelley L Young, Alison K Conlin, Lora R Weiselberg, Jerry W Mitchell, Christine A Ambrosone, Tim A Ahles, Gary R Morrow
Purpose Cancer-related cognitive impairment is an important problem for patients with breast cancer, yet its trajectory is not fully understood. Some previous cancer-related cognitive impairment research is limited by heterogeneous populations, small samples, lack of prechemotherapy and longitudinal assessments, use of normative data, and lack of generalizability. We addressed these limitations in a large prospective, longitudinal, nationwide study. Patients and Methods Patients with breast cancer from community oncology clinics and age-matched noncancer controls completed the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) at prechemotherapy and postchemotherapy and at a 6-month follow-up as an a priori exploratory aim...
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28025724/safety-and-efficacy-of-anti-amyloid-%C3%AE-immunotherapy-in-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#14
Ross Penninkilampi, Holly M Brothers, Guy D Eslick
Immunotherapeutics targeting amyloid-β (Aβ) have had mixed results in clinical trials. The present study aims to evaluate the safety and clinical efficacy of immunotherapeutic agents targeting Aβ in Alzheimer's disease. Randomised controlled trials of at least two weeks duration were included in the review. Fourteen randomised controlled trials (n = 5554) were identified in a systematic search of eight electronic databases. Upon pooling of data, there was no increased risk of any adverse event, serious adverse events, or death with the exception of a near fivefold increase in amyloid-related imaging abnormalities (ARIA; OR 4...
December 26, 2016: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28006822/screening-for-dementia-in-older-adults-comparison-of-mini-mental-state-examination-mini-cog-clock-drawing-test-and-ad8
#15
Li Yang, Jing Yan, Xiaoqing Jin, Yu Jin, Wei Yu, Shanhu Xu, Haibin Wu
This study was conducted to estimate screening performance of dementia screening tools including Mini-Mental State Examination (MMSE), Mini-Cog, Clock Drawing Test (CDT) and Ascertain Dementia 8 questionnaire (AD8) for older adults. 2015 participants aged 65 years or more in eastern China were enrolled. 4 screening tests were administered and scored by specifically trained psychiatrists. We used data from two-by-two tables to calculate the sensitivity, specificity, and positive and negative predictive values (PPV/NPV)...
2016: PloS One
https://www.readbyqxmd.com/read/28001296/spatial-distribution-of-intermingling-pools-of-projection-neurons-with-distinct-targets-a-3-dimensional-analysis-of-the-commissural-ganglia-in-cancer-borealis
#16
Rosangela Follmann, Christopher John Goldsmith, Wolfgang Stein
Projection neurons play a key role in carrying long-distance information between spatially distant areas of the nervous system and in controlling motor circuits. Little is known about how projection neurons with distinct anatomical targets are organized, and few studies have addressed their spatial organization at the level of individual cells. In the paired commissural ganglia (CoGs) of the stomatogastric nervous system of the crab Cancer borealis, projection neurons convey sensory, motor, and modulatory information to several distinct anatomical regions...
December 21, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27997622/dexamethasone-chemotherapy-does-not-disrupt-orexin-signaling
#17
David E Kram, Stephanie M Krasnow, Peter R Levasseur, Xinxia Zhu, Linda C Stork, Daniel L Marks
BACKGROUND: Steroid-induced sleep disturbance is a common and highly distressing morbidity for children receiving steroid chemotherapy for the treatment of pediatric acute lymphoblastic leukemia (ALL). Sleep disturbance can negatively impact overall quality of life, neurodevelopment, memory consolidation, and wound healing. Hypothalamic orexin neurons are influential wake-promoting neurons, and disturbances in orexin signaling leads to abnormal sleep behavior. A new class of drug, the orexin receptor antagonists, could be an intriguing option for sleep disorders caused by increased orexinergic output...
2016: PloS One
https://www.readbyqxmd.com/read/27989939/high-resolution-mass-spectrometry-based-global-proteomic-analysis-of-probiotic-strains-lactobacillus-fermentum-ncdc-400-and-rs2
#18
Parijat Pragya, Gurjeet Kaur, Syed Azmal Ali, Shveta Bhatla, Preeti Rawat, Vaibhao Lule, Sudarshan Kumar, Ashok Kumar Mohanty, Pradip Behare
Lactobacillus fermentum strains NCDC 400 and RS2, previously isolated from dairy sources, exhibited excellent probiotic properties were studied for the global proteomic profile. A total of 1125 proteins were identified by a high-resolution mass spectrometer, ESI-qTOF (nano-LC-MS/MS) in the strains of L. fermentum. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis resulted in 60.9% and 59.2% of the total proteins were functionally annotated for NCDC 400 and RS2 respectively. Simultaneously, a cluster of orthologous groups (COGs) and KEGG together revealed the presence of a significant number of proteins involved in transcription, translation, chaperones, peptidoglycan biosynthesis, nucleotide, amino acid and carbohydrate metabolism...
January 30, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27974726/genome-information-of-maribacter-dokdonensis-dsw-8-and-comparative-analysis-with-other-maribacter-genomes
#19
Min-Jung Kwak, Jidam Lee, Soon-Kyeong Kwon, Jihyun F Kim
Maribacter dokdonensis DSW-8 was isolated from the seawater off Dokdo in Korea. To investigate the genomic features of this marine bacterium, we sequenced its genome and analyzed the genomic features. After de novo assembly and gene prediction, 16 contigs totaling 4,434,543 bp (35.95% G+C content) in size were generated and 3,835 protein-coding sequences, 36 transfer RNAs, and 6 ribosomal RNAs were detected. In the genome of DSW-8, genes encoding the proteins associated with gliding motility, molybdenum cofactor biosynthesis, and utilization of several kinds of carbohydrates were identified...
December 14, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27965162/transcriptome-profiling-of-developing-spleen-tissue-and-discovery-of-immune-related-genes-in-grass-carp-ctenopharyngodon-idella
#20
Guoxi Li, Yinli Zhao, Jie Wang, Bianzhi Liu, Xiangli Sun, Shuang Guo, Jianxin Feng
Grass carp Ctenopharyngodon idella is an important freshwater aquaculture species. However, studies regarding transcriptomic profiling of developing spleen tissue in the grass carp are lacking. Here, the transcriptome sequencing from the spleen tissue of one-year-old (cis1) and three-year-old (cis3) grass carp was performed using Illumina paired-end sequencing technology. The de novo assemblies yielded 48,970 unigenes with average lengths of 1264.51 bp from the two libraries. The assembled unigenes were evaluated and functionally annotated by comparing with sequences in major public databases including Nr, COG, Swiss-Prot, KEGG, Pfam and GO...
December 11, 2016: Fish & Shellfish Immunology
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