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https://www.readbyqxmd.com/read/29345724/effects-of-cognitive-training-on-cognition-and-quality-of-life-of-older-persons-with-dementia
#1
Eeva-Liisa Kallio, Hannareeta Öhman, Marja Hietanen, Helena Soini, Timo E Strandberg, Hannu Kautiainen, Kaisu H Pitkälä
OBJECTIVES: To evaluate the effect of cognitive training on cognition and health-related quality of life (HRQoL) in community-dwelling persons with dementia. DESIGN: Single-blind randomized controlled trial with 3- and 9-month follow-up. SETTING: Adult day care centers in Helsinki, Finland. PARTICIPANTS: Older individuals with mild to moderate dementia living at home and attending adult day care twice a week (N = 147; mean age 83, 72% female, 63% at mild stage of dementia)...
January 18, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29339664/cenesthopathy-and-subjective-cognitive-complaints-an-exploratory-study-in-schizophrenia
#2
Natalia Jimeno, Martin L Vargas
BACKGROUND/AIMS: Cenesthopathy is mainly associated with schizophrenia; however, its neurobiological basis is nowadays unclear. The general objective was to explore clinical correlates of cenesthopathy and subjective cognitive complaints in schizophrenia. METHODS: Participants (n = 30) meeting DSM-IV criteria for psychotic disorder were recruited from a psychiatry unit and assessed with: Association for Methodology and Documentation in Psychiatry (AMDP) system, Positive and Negative Syndrome Scale, Frankfurt Complaint Questionnaire (FCQ), and the Bonn Scale for the Assessment of Basic Symptoms (BSABS)...
January 16, 2018: Psychopathology
https://www.readbyqxmd.com/read/29336817/neurocognitive-assessment-in-patients-with-a-minor-traumatic-brain-injury-and-an-abnormal-initial-ct-scan-can-cognitive-evaluation-assist-in-identifying-patients-who-require-surveillance-ct-brain-imaging
#3
Thomas W Clements, Michael Dunham, Andrew Kirkpatrick, Ruphus Rajakumar, Carolyn Gratton, Rohan Lall, Paul McBeth, Chad G Ball
BACKGROUND: Evidence for repeat computed tomography (CT) in minor traumatic brain injury (mTBI) patients with intracranial pathology is scarce. The aim of this study was to investigate the utility of clinical cognitive assessment (COG) in defining the need for repeat imaging. METHODS: COG performance was compared with findings on subsequent CT, and need for neurosurgery in mTBI patients (GCS 13-15 and positive CT findings). RESULTS: Of 152 patients, 65...
January 5, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29332202/non-amidated-and-amidated-members-of-the-c-type-allatostatin-ast-c-family-are-differentially-distributed-in-the-stomatogastric-nervous-system-of-the-american-lobster-homarus-americanus
#4
Andrew E Christie, Alexandra Miller, Rebecca Fernandez, Evyn S Dickinson, Audrey Jordan, Jessica Kohn, Mina C Youn, Patsy S Dickinson
The crustacean stomatogastric nervous system (STNS) is a well-known model for investigating neuropeptidergic control of rhythmic behavior. Among the peptides known to modulate the STNS are the C-type allatostatins (AST-Cs). In the lobster, Homarus americanus, three AST-Cs are known. Two of these, pQIRYHQCYFNPISCF (AST-C I) and GNGDGRLYWRCYFNAVSCF (AST-C III), have non-amidated C-termini, while the third, SYWKQCAFNAVSCFamide (AST-C II), is C-terminally amidated. Here, antibodies were generated against one of the non-amidated peptides (AST-C I) and against the amidated isoform (AST-C II)...
January 13, 2018: Invertebrate Neuroscience: IN
https://www.readbyqxmd.com/read/29332190/transcriptomic-profiling-of-developing-fiber-in-levant-cotton-gossypium-herbaceum-l
#5
Mithil J Parekh, Sushil Kumar, Ranbir S Fougat, Harshvardhan N Zala, Ramesh J Pandit
Cotton (Gossypium spp.) is an imperative economic crop of the globe due to its natural textile fiber. Molecular mechanisms of fiber development have been greatly revealed in allotetraploid cotton but remained unexplored in Gossypium herbaceum. G. herbaceum can withstand the rigors of nature like drought and pests but produce coarse lint. This undesirable characteristic strongly needs the knowledge of fiber development at molecular basis. The present study reported the transcriptome sequence of the developing fiber of G...
January 13, 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29325011/cognitive-complaints-in-memory-clinic-patients-and-in-depressive-patients-an-interpretative-phenomenological-analysis
#6
Lisa Miebach, Steffen Wolfsgruber, Ingo Frommann, Klaus Fließbach, Frank Jessen, Rachel Buckley, Michael Wagner
Background and Objectives: Cognitive complaints are discussed as early signs of Alzheimer's disease (AD). However, they are also very common in cognitively normal older adults and in patients with depression. Qualitative, interview-based approaches might be useful to identify those features of cognitive complaints specific for the experiences of cognitive decline in preclinical or prodromal AD versus those complaints typically reported by depressed patients. Research Design and Methods: A semi-structured interview was administered to 21 cognitively normal older adults (HC), 18 nondemented memory clinic patients (MC), and 11 patients with a major depression (MD), all above 55 years...
January 8, 2018: Gerontologist
https://www.readbyqxmd.com/read/29321553/prediction-of-co-expression-genes-and-integrative-analysis-of-gene-microarray-and-proteomics-profile-of-keshan-disease
#7
Sen Wang, Rui Yan, Bin Wang, Peiru Du, Wuhong Tan, Mikko J Lammi, Xiong Guo
Keshan disease (KD) is a kind of endemic cardiomyopathy which has a high mortality. However, molecular mechanism in the pathogenesis of KD remains poorly understood. Serum samples were collected from 112 KD patients and 112 normal controls. Gene microarray was used to screen differently expressed genes. Genevestigator was applied to forecast co-expression genes of significant gene. iTRAQ proteomics analysis was used to verify significant genes and their co-expression genes. GO, COG, IPA and STRING were applied to undertake function categorization, pathway and network analysis separately...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318278/effect-of-idalopirdine-as-adjunct-to-cholinesterase-inhibitors-on-change-in-cognition-in-patients-with-alzheimer-disease-three-randomized-clinical-trials
#8
Alireza Atri, Lutz Frölich, Clive Ballard, Pierre N Tariot, José Luis Molinuevo, Neli Boneva, Kristian Windfeld, Lars L Raket, Jeffrey L Cummings
Importance: New therapeutic approaches for Alzheimer disease (AD) are needed. Objective: To assess whether idalopirdine, a selective 5-hydroxytryptamine-6 receptor antagonist, is effective for symptomatic treatment of mild to moderate AD. Design, Setting, and Participants: Three randomized clinical trials that included 2525 patients aged 50 years or older with mild to moderate AD (study 1: n = 933 patients at 119 sites; study 2: n = 858 at 158 sites; and study 3: n = 734 at 126 sites)...
January 9, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29316673/transcriptome-analysis-in-haematococcus-pluvialis-astaxanthin-induction-by-high-light-with-acetate-and-fe2
#9
Bangxiang He, Lulu Hou, Manman Dong, Jiawei Shi, Xiaoyun Huang, Yating Ding, Xiaomei Cong, Feng Zhang, Xuecheng Zhang, Xiaonan Zang
Haematococcus pluvialis is a commercial microalga, that produces abundant levels of astaxanthin under stress conditions. Acetate and Fe2+ are reported to be important for astaxanthin accumulation in H. pluvialis. In order to study the synergistic effects of high light stress and these two factors, we obtained transcriptomes for four groups: high light irradiation (HL), addition of 25 mM acetate under high light (HA), addition of 20 μM Fe2+ under high light (HF) and normal green growing cells (HG). Among the total clean reads of the four groups, 156,992 unigenes were found, of which 48...
January 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29315963/distinct-and-heterogeneous-trajectories-of-self-perceived-cognitive-impairment-among-asian-breast-cancer-survivors
#10
Terence Ng, Sreemanee Raaj Dorajoo, Yin Ting Cheung, Yick Ching Lam, Hui Ling Yeo, Maung Shwe, Yan Xiang Gan, Koon Mian Foo, Wei-Jen Kiley Loh, Si-Lin Koo, Amit Jain, Guek Eng Lee, Rebecca Dent, Yoon Sim Yap, Raymond Ng, Alexandre Chan
OBJECTIVES: Currently, there are no studies that have established the self-perceived cognitive trajectories experienced by breast cancer patients (BCPs) post-chemotherapy. Therefore, we characterized the long-term trajectory of self-perceived cognitive function among Asian early-stage BCPs using the minimal clinically important difference (MCID) of a subjective measure of cognitive function. METHODS: Early-stage BCPs who received chemotherapy were recruited and assessed at four time points: Before chemotherapy initiation (T1), 6 weeks post-chemotherapy initiation (T2), 12 weeks post-chemotherapy initiation (T3), and 15-months post-chemotherapy initiation (T4)...
January 9, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29313215/association-of-mitochondrial-dna-content-in-peripheral-blood-with-cancer-related-fatigue-and-chemotherapy-related-cognitive-impairment-in-early-stage-breast-cancer-patients-a-prospective-cohort-study
#11
Jung-Woo Chae, Peh Siang Chua, Terence Ng, Angie Hui Ling Yeo, Maung Shwe, Yan Xiang Gan, Sreemanee Dorajoo, Koon Mian Foo, Kiley Wei-Jen Loh, Si-Lin Koo, Wen Yee Chay, Tira Jing Ying Tan, Sok Yuen Beh, Elaine Hsuen Lim, Guek Eng Lee, Rebecca Dent, Yoon Sim Yap, Raymond Ng, Han Kiat Ho, Alexandre Chan
PURPOSE: Cancer-related fatigue (CRF) and chemotherapy-related cognitive impairment (CRCI) are reported to be associated with mitochondrial dysfunction. Hence, mitochondrial DNA (mtDNA) content, a biomarker of mitochondrial dysfunction, is hypothesized to correlate with the onset of CRF and CRCI. This study aims to evaluate the association between peripheral blood mtDNA content reduction and severity of CRF and CRCI in patients receiving chemotherapy. METHODS: This was a prospective cohort study...
January 8, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29305080/de-novo-transcriptomic-analysis-of-the-venomous-glands-from-the-scorpion-heterometrus-spinifer-revealed-unique-and-extremely-high-diversity-of-the-venom-peptides
#12
Yuchen Deng, Jiawei Gu, Zhenpeng Yan, Mengdi Wang, Chaoqun Ma, Jiafeng Zhang, Guixian Jiang, Mengxiao Ge, Shuogui Xu, Zheng Xu, Liang Xiao
Scorpion, as an ancient species, has been widely used on dozens of human diseases in traditional Chinese Medicine. Although the scorpion venom from the Buthidae family with the potent toxicity attracts more interests, toxins from the non-Buthidae family draw great attention as well because of its abundance and complexity even without harm to mammals. Moreover, several toxic components of scorpion venom have been identified as valuable scaffolds for the drug design and development. Using the Next Generation Sequencing (NGS) technique, here we reported the transcriptome of the venomous glands of Heterometrus spinifer, a non-Buthidae scorpion that only a few toxic and complete components have been identified known-to-date...
January 2, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29286511/cerebral-impact-of-prenatal-irradiation-by-131i-an-experimental-model-of-clinical-neuroradioembryological-effects
#13
V V Talko, K M Loganovsky, I P Drozd, Ye V Tukalenko, T K Loganovska, S Yu Nechayev, S V Masiuk, Ye M Prokhorova
Human brain in prenatal period is a most vulnerable to ionizing radiation body structure. Unlike atomic bombings or radiological interventions in healthcare leading at most to external irradiation the intensive internal exposure may occur upon nuclear reactor accidents followed by substantial release and fallout of radioactive 131I. The latter can lead to specific neuroradioembryological effects. OBJECTIVE: To create an experimental model of prenatal cerebral radiation effects of 131I in human and to determine the experimental and clinical neuroradioembryological effects...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29286496/evoked-bioelectrical-brain-activity-following-exposure-to-ionizing-radiation
#14
K Loganovsky, K Kuts
The article provides an overview of modern physiological evidence to support the hypothesis on cortico limbic sys tem dysfunction due to the hippocampal neurogenesis impairment as a basis of the brain interhemispheric asym metry and neurocognitive deficit after radiation exposure. The importance of the research of both evoked poten tials and fields as a highly sensitive and informative method is emphasized.Particular attention is paid to cerebral sensor systems dysfunction as a typical effect of ionizing radiation...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29284596/measurable-residual-disease-detection-by-high-throughput-sequencing-improves-risk-stratification-for-pediatric-b-all
#15
Brent Wood, David Wu, Beryl Crossley, Yunfeng Dai, David Williamson, Charles Gawad, Michael J Borowitz, Meenakshi Devidas, Kelly W Maloney, Eric Larsen, Naomi Winick, Elizabeth Raetz, William L Carroll, Stephen P Hunger, Mignon Loh, Harlan Robins, Ilan Kirsch
Early response to induction chemotherapy is an important prognostic factor in B lymphoblastic leukemia (B-ALL). Here, we compare high throughput sequencing (HTS) of IGH and TRG genes versus flow cytometry (FC) for measurable residual disease (MRD) detection at the end of induction chemotherapy in pediatric patients with newly diagnosed B-ALL. 619 paired pretreatment and end of induction bone marrow samples from Children's Oncology Group (COG) studies AALL0331 (clinicaltrials.gov NCT00103285) (standard-risk; SR with MRD by FC at any level) and AALL0232 (clinicaltrials...
December 28, 2017: Blood
https://www.readbyqxmd.com/read/29284465/acupuncture-for-patients-with-mild-to-moderate-alzheimer-s-disease-a-randomized-controlled-trial
#16
Yujie Jia, Xuezhu Zhang, Jianchun Yu, Jingxian Han, Tao Yu, Jiangwei Shi, Lan Zhao, Kun Nie
BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia. However, none of medical treatment can stop or reverse the underlying neurodegenerative of AD at present. Acupuncture has attracted more and more attention in recent years due to its efficacy and very few side effects. Lately, a systematic review has thought that the evidence on the effectiveness of acupuncture in improving the cognitive function of AD patients was not powerful enough. Therefore, the aim of this study is to explore the efficacy and safety of acupuncture in patients with mild to moderate AD...
December 29, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29278374/nonvolatile-resistive-switching-memory-utilizing-cobalt-embedded-in-gelatin
#17
Cheng-Jung Lee, Yu-Chi Chang, Li-Wen Wang, Yeong-Her Wang
This study investigates the preparation and electrical properties of Al/cobalt-embedded gelatin (CoG)/ indium tin oxide (ITO) resistive switching memories. Co. elements can be uniformly distributed in gelatin without a conventional dispersion procedure, as confirmed through energy dispersive X-ray analyzer and X-ray photoelectron spectroscopy observations. With an appropriate Co. concentration, Co. ions can assist the formation of an interfacial AlOx layer and improve the memory properties. High ON/OFF ratio, good retention capability, and good endurance switching cycles are demonstrated with 1 M Co...
December 26, 2017: Materials
https://www.readbyqxmd.com/read/29276571/draft-genome-sequence-of-dethiosulfovibrio-salsuginis-dsm-21565t-an-anaerobic-slightly-halophilic-bacterium-isolated-from-a-colombian-saline-spring
#18
Carolina Díaz-Cárdenas, Gina López, José David Alzate-Ocampo, Laura N González, Nicole Shapiro, Tanja Woyke, Nikos C Kyrpides, Silvia Restrepo, Sandra Baena
A bacterium belonging to the phylum Synergistetes, genus Dethiosulfovibrio was isolated in 2007 from a saline spring in Colombia. Dethiosulfovibrio salsuginis USBA 82T (DSM 21565T= KCTC 5659T) is a mesophilic, strictly anaerobic, slightly halophilic, Gram negative bacterium with a diderm cell envelope. The strain ferments peptides, amino acids and a few organic acids. Here we present the description of the complete genome sequencing and annotation of the type species Dethiosulfovibrio salsuginis USBA 82T. The genome consisted of 2...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29276381/a-new-data-analysis-approach-for-measuring-longitudinal-changes-of-metabolism-in-cognitively-normal-elderly-adults
#19
Sepideh Shokouhi, William R Riddle, Hakmook Kang
Introduction: Previously, we discussed several critical barriers in including [18F] fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) imaging of preclinical Alzheimer's disease (AD) subjects. These factors included the reference region selection and intensity normalization of PET images and the within- and across-subject variability of affected brain regions. In this study, we utilized a novel FDG-PET analysis, the regional FDG time correlation coefficient, rFTC, that can address and resolve these barriers and provide a more sensitive way of monitoring longitudinal changes in metabolism of cognitively normal elderly adults...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29274118/cost-comparison-by-treatment-arm-and-center-level-variations-in-cost-and-inpatient-days-on-the-phase-iii-high-risk-b-acute-lymphoblastic-leukemia-trial-aall0232
#20
Amanda M DiNofia, Alix E Seif, Meenakshi Devidas, Yimei Li, Matthew Hall, Yuan-Shung V Huang, Viviane Cahen, Stephen P Hunger, Naomi J Winick, William L Carroll, Brian T Fisher, Eric C Larsen, Richard Aplenc
The Children's Oncology Group (COG) develops and implements multi-institutional clinical trials with the primary goal of assessing the efficacy and safety profile of treatment regimens for various pediatric cancers. However, the monetary costs of treatment regimens are not measured. AALL0232 was a COG randomized phase III trial for children with acute lymphoblastic leukemia that found that dexamethasone (DEX) was a more effective glucocorticoid than prednisone (PRED) in patients younger than 10 years, but PRED was equally effective and less toxic in older patients...
December 23, 2017: Cancer Medicine
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