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https://www.readbyqxmd.com/read/28731731/current-driven-instability-of-the-quantum-anomalous-hall-effect-in-ferromagnetic-topological-insulators
#1
Minoru Kawamura, Ryutaro Yoshimi, Atsushi Tsukazaki, Kei S Takahashi, Masashi Kawasaki, Yoshinori Tokura
The instability of the quantum anomalous Hall (QAH) effect has been studied as a function of the electric current and temperature in ferromagnetic topological insulator thin films. We find that a characteristic current for the breakdown of the QAH effect is roughly proportional to the Hall-bar width, indicating that the Hall electric field is relevant to the breakdown. We also find that electron transport is dominated by variable range hopping (VRH) at low temperatures. Combining the current and temperature dependences of the conductivity in the VRH regime, the localization length of the QAH state is evaluated to be about 5  μm...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28728763/implementation-of-a-school-nurse-led-intervention-for-children-with-severe-obesity-in-new-york-city-schools
#2
Krista Schroeder, Haomiao Jia, Y Claire Wang, Arlene Smaldone
PURPOSE: The Healthy Options and Physical Activity Program (HOP) is a school nurse-led intervention for children with severe obesity. HOP was developed by experts at the New York City Department of Health and Mental Hygiene and implemented in New York City schools beginning in 2012. The purpose of this study was to evaluate HOP implementation with the goal of informing HOP refinement and potential future HOP dissemination. DESIGN AND METHODS: This study entailed a retrospective analysis of secondary data...
July 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28728527/antiretroviral-nonadherence-and-condomless-sex-in-the-hiv-outpatient-study-usa-2007-2014
#3
M D Durham, R Hart, K Buchacz, J Hammer, B Young, D Yang, K Wood, B Yangco, J T Brooks
Effective antiretroviral therapy (ART) reduces plasma HIV RNA viral load (VL) to undetectable levels and its effectiveness depends on consistent adherence. Consistent adherence and use of safe sex practices may substantially decrease the risk of HIV transmission. We sought to explore the potential association between self-reported nonadherence to ART and engaging in unsafe sexual practices capable of transmitting HIV. Using clinical and audio computer-assisted self-interview data from the prospective HIV Outpatient Study from 2007 to 2014, we assessed the frequency of self-reported ART nonadherence during the three days prior to the survey among HIV-infected persons in care and factors associated with self-reported ART nonadherence...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28728042/pharmacological-relationships-and-ligand-discovery-of-g-protein-coupled-receptors-revealed-by-simultaneous-ligand-and-receptor-clustering
#4
Cheng Zhang, Yi-Ming Shao, Xiaohua Ma, Siew Lee Cheong, Chu Qin, Lin Tao, Peng Zhang, Shangying Chen, Xian Zeng, Hongxia Liu, Giorgia Pastorin, Yuyang Jiang, Yu Zong Chen
Conventional ligand and receptor similarity methods have been extensively used for exposing pharmacological relationships and drug lead discovery. They may in some cases neglect minor relationships useful for target hopping particularly against the remote family members. To complement the conventional methods for capturing these minor relationships, we developed a new method that uses a SLARC (Simultaneous Ligand And Receptor Clustering) 2D map to simultaneously characterize the ligand structural and receptor binding-site sequence relationships of a receptor family...
July 11, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28726881/effects-of-co2-adsorption-on-proton-migration-on-a-hydrated-zro2-surface-an-ab-initio-molecular-dynamics-study
#5
Ryuhei Sato, Yasushi Shibuta, Fuyuki Shimojo, Shu Yamaguchi
Hydration reactions on a carbonate-terminated cubic ZrO2(110) surface were analyzed using ab initio molecular dynamics (AIMD) simulations. After hydration reactions, carbonates were still present on the surface at 500 K. However, these carbonates are very weak conjugate bases and only act as steric hindrance in proton hopping processes between acidic chemisorbed H2O molecules (Zr-OH2) and monodentate hydroxyl groups (Zr-OH(-)). Similar to a carbonate-free hydrated surface, Zr-OH2, Zr-OH(-), and polydentate hydroxyl groups ([double bond splayed left]OH(+)) were observed, while the ratio of acidic Zr-OH2 was significantly larger than that on the carbonate-free hydrated surface...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28725376/moving-south-effects-of-water-temperatures-on-the-larval-development-of-invasive-cane-toads-rhinella-marina-in-cool-temperate-australia
#6
Uditha Wijethunga, Matthew Greenlees, Richard Shine
The distributional limits of many ectothermic species are set by thermal tolerances of early-developmental stages in the life history; embryos and larvae often are less able to buffer environmental variation than are conspecific adults. In pond-breeding amphibians, for example, cold water may constrain viability of eggs and larvae, even if adults can find suitable thermal conditions in terrestrial niches. Invasive species provide robust model systems for exploring these questions, because we can quantify thermal challenges at the expanding range edge (from field surveys) and larval responses to thermal conditions (in the laboratory)...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28723223/free-energy-of-binding-and-mechanism-of-interaction-for-the-meevd-tpr2a-peptide-protein-complex
#7
Mauro Lapelosa
The association between the MEEVD C-terminal peptide from the heat shock protein 90 (Hsp90) and tetratricopeptide repeat A (TPR2A) domain of the heat shock organizing protein (Hop) is a useful prototype to study the fundamental molecular details about the Hop-Hsp90 interaction. We study here the mechanism of binding/unbinding, and compute the standard binding free energy and potential of mean force for the association of the MEEVD peptide to the TPR2A domain using the Adaptive Biasing Force (ABF) methodology...
July 19, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28721206/a-bipedal-mammalian-model-for-spinal-cord-injury-research-the-tammar-wallaby
#8
Norman R Saunders, Katarzyna M Dziegielewska, Sophie C Whish, Lyn A Hinds, Benjamin J Wheaton, Yifan Huang, Steve Henry, Mark D Habgood
Background: Most animal studies of spinal cord injury are conducted in quadrupeds, usually rodents. It is unclear to what extent functional results from such studies can be translated to bipedal species such as humans because bipedal and quadrupedal locomotion involve very different patterns of spinal control of muscle coordination. Bipedalism requires upright trunk stability and coordinated postural muscle control; it has been suggested that peripheral sensory input is less important in humans than quadrupeds for recovery of locomotion following spinal injury...
2017: F1000Research
https://www.readbyqxmd.com/read/28719213/full-dimensional-excited-state-intramolecular-proton-transfer-dynamics-of-salicylic-acid
#9
Tim Raeker, Bernd Hartke
Not all photodynamical processes are ultrafast processes in the range of 100 fs. Thus, using high-level ab initio methods for systems evolving along deactivation pathways in the excited state for picoseconds is not feasible. We will present full-dimensional photodynamics using the floating-occupation configuration-interaction (FOCI) treatment with single and paired double excitations based on the semiempirical RM1 Hamiltonian. Salicylic acid (SAc) served as our sample system which is a well-studied system both experimentally and theoretically by static calculations...
July 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28718762/sec17-sec18-act-twice-enhancing-membrane-fusion-and-then-disassembling-cis-snare-complexes
#10
Hongki Song, Amy S Orr, Mengtong Duan, Alexey J Merz, William T Wickner
At physiological protein levels, the slow HOPS- and SNARE-dependent fusion which occurs upon complete SNARE zippering is stimulated by Sec17 and Sec18:ATP without requiring ATP hydrolysis. To stimulate, Sec17 needs its central residues which bind the 0-layer of the SNARE complex and its N-terminal apolar loop. Adding a transmembrane anchor to the N-terminus of Sec17 bypasses this requirement for apolarity of the Sec17 loop, suggesting that the loop functions for membrane binding rather than to trigger bilayer rearrangement...
July 18, 2017: ELife
https://www.readbyqxmd.com/read/28718283/disordered-linker-in-p53-participates-in-non-specific-binding-to-and-1d-sliding-along-dna-revealed-by-single-molecule-fluorescence-measurements
#11
Dwiky Rendra Graha Subekti, Agato Murata, Yuji Itoh, Satoshi Fukuchi, Hiroto Takahashi, Saori Kanbayashi, Satoshi Takahashi, Kiyoto Kamagata
The tumor suppressor p53 is a multidomain transcription factor that can quickly bind to its target DNA by sliding along the DNA strand. We hypothesized that the intrinsically disordered and positively charged linker of p53 regulates its search dynamics first by directly interacting with DNA and second by modulating hopping of the core domain. To test the two hypotheses, we prepared five variants of p53 in which the length and charge of the linker were modulated. Affinity to and sliding along non-specific DNA of p53 were altered by the charge of the linker, but not by the linker length...
July 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/28718171/younger-patients-and-men-achieve-higher-outcome-scores-than-older-patients-and-women-after-anterior-cruciate-ligament-reconstruction
#12
Kate E Webster, Julian A Feller
BACKGROUND: There is some evidence that functional performance and validated outcome scores differ according to the gender, age, and sport participation status of a patient after anterior cruciate ligament (ACL) reconstruction. However, the impact of these three factors, and interaction among them, has not been studied across a large relatively homogeneous group of patients to better elucidate their impact. QUESTIONS/PURPOSES: We reviewed a large cohort of patients who had undergone ACL reconstruction to determine if ROM, knee laxity, objective performance measures, and validated outcome scores differed according to (1) gender; (2) age; and (3) sport participation status...
July 17, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28714860/charge-carrier-relaxation-in-ingaas-gaas-quantum-wire-modulation-doped-heterostructures
#13
Serhiy Kondratenko, Sviatoslav Iliash, Yuriy I Mazur, Vasyl P Kunets, Mourad Benamara, Gregory J Salamo
The time dependencies of the carrier relaxation in the modulation-doped InGaAs-GaAs low-dimensional structures with quantum wires have been studied as function of temperature and light excitation levels. The photoconductivity relaxation follows a stretched exponent with decay constant, which depends on morphology of InGaAs epitaxial layers, presence of deep traps and on energy disorder due to inhomogeneous distribution of size and composition. A hopping model, where electrons tunnel between bands of localized states, gives appropriate interpretation for temperature-independent PC decay across the temperature range 150-290 K...
July 17, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28714826/effects-of-peroneal-muscles-fatigue-on-dynamic-stability-following-lateral-hop-landing-time-to-stabilization-vs-dynamic-postural-stability-index
#14
Kazem Malmir, Gholam Reza Olyaei, Saeed Talebian, Ali Ashraf Jamshidi, Majid Ashraf Ganguie
CONTEXT: Dynamic stability is a necessary requirement in many sports competitions. Muscle fatigue, which can impair stability, may be occurred in many sports competitions in which lateral movements and landing repeated frequently. OBJECTIVE: To assess the effects of peroneal muscles fatigue on dynamic stability following lateral hop landing through measuring time to stabilization (TTS) and dynamic postural stability index (DPSI). DESIGN: Quasi-experimental...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28714786/effects-of-a-prophylactic-knee-sleeve-on-anterior-cruciate-ligament-loading-during-sport-specific-movements
#15
Jonathan Sinclair, Paul John Taylor
CONTEXT: Prophylactic knee bracing is extensively utilized in athletic populations, to reduce the high risk from knee injuries, but their role in the attenuation of anterior cruciate ligament (ACL) pathologies is not well understood. OBJECTIVE: The aim of the current investigation was to investigate the effects of a prophylactic knee sleeve on ACL loading parameters linked to the aetiology of injury in recreational athletes. SETTING: Laboratory...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28713398/a-hops-protein-movps41-is-crucially-important-for-vacuolar-morphogenesis-vegetative-growth-reproduction-and-virulence-in-magnaporthe-oryzae
#16
Xiaojie Zhang, Guanghui Wang, Chengdong Yang, Jun Huang, Xiaofeng Chen, Jie Zhou, Guangpu Li, Justice Norvienyeku, Zonghua Wang
The homotypic fusion and protein sorting protein complex (HOPS) is the first known tether complex identified in the endocytic system that plays a key role in promoting homotypic vacuolar fusion, vacuolar biogenesis and trafficking in a wide range of organisms, including plant and fungi. However, the exact influence of the HOPS complex on growth, reproduction and pathogenicity of the economically destructive rice blast fungus has not been investigated. In this study, we identified M. oryzae vacuolar protein sorting 41 (MoVps41) an accessory subunit of HOPS complex and used targeted gene deletion approach to evaluate its contribution to growth, reproduction and infectious life cycle of the rice blast fungus...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28711500/atvps11-is-essential-for-vacuole-biogenesis-in-embryo-and-participates-in-pollen-tube-growth-in-arabidopsis
#17
Xiaoyun Tan, Juan Wei, Beibei Li, Mengru Wang, Yiqun Bao
Vacuoles are multiple functional and essential organelles in plants. Studies in Saccharomyces cerevisiae had identified a tethering factor HOPS (Homotypic Fusion and Vacuolar Protein Sorting) complex that plays a critical role in vacuole biogenesis. The HOPS complex consists of four core subunits (Vps11, Vps16, Vps18 and Vps33) and two special subunits (Vps39 and Vps41). All these subunits were found in Arabidopsis, and our knowledge of the function of Arabidopsis HOPS complex are still limited. In this study, we investigated the function of AtVps11 gene in Arabidopsis, we found that vps11/- lead to embryo lethal, vacuole biogenesis in embryo was impaired...
July 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28711052/diffusion-and-reaction-pathways-of-water-near-fully-hydrated-tio2-surfaces-from-ab-initio-molecular-dynamics
#18
Lorenzo Agosta, Erik G Brandt, Alexander P Lyubartsev
Ab initio molecular dynamics simulations are reported for water-embedded TiO2 surfaces to determine the diffusive and reactive behavior at full hydration. A three-domain model is developed for six surfaces [rutile (110), (100), and (001), and anatase (101), (100), and (001)] which describes waters as "hard" (irreversibly bound to the surface), "soft" (with reduced mobility but orientation freedom near the surface), or "bulk." The model explains previous experimental data and provides a detailed picture of water diffusion near TiO2 surfaces...
July 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28709355/genuine-localization-transition-in-a-long-range-hopping-model
#19
Xiangyu Cao, Alberto Rosso, Jean-Philippe Bouchaud, Pierre Le Doussal
We introduce and study a banded random matrix model describing sparse, long-range quantum hopping in one dimension. Using a series of analytic arguments, numerical simulations, and a mapping to a long-range epidemics model, we establish the phase diagram of the model. A genuine localization transition, with well defined mobility edges, appears as the hopping rate decreases slower than ℓ^{-2}, where ℓ is the distance. Correspondingly, the decay of the localized states evolves from a standard exponential shape to a stretched exponential and finally to a exp(-Cln^{κ}ℓ) behavior, with κ>1...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28709254/bose-einstein-condensation-in-chains-with-power-law-hoppings-exact-mapping-on-the-critical-behavior-in-d-dimensional-regular-lattices
#20
W S Dias, D Bertrand, M L Lyra
Recent experimental progress on the realization of quantum systems with highly controllable long-range interactions has impelled the study of quantum phase transitions in low-dimensional systems with power-law couplings. Long-range couplings mimic higher-dimensional effects in several physical contexts. Here, we provide the exact relation between the spectral dimension d at the band bottom and the exponent α that tunes the range of power-law hoppings of a one-dimensional ideal lattice Bose gas. We also develop a finite-size scaling analysis to obtain some relevant critical exponents and the critical temperature of the BEC transition...
June 2017: Physical Review. E
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