Chujian Ma, Luyang Tian, Yan-En Wang, Jingqian Huo, Zexiu An, Susu Sun, Song Kou, Wenfei Wang, Yaze Li, Jinlin Zhang, Lai Chen
To discover novel transketolase (TKL, EC 2.2.1.1) inhibitors with potential herbicidal applications, a series of pyrazole acyl thiourea derivatives were designed based on a previously obtained pyrazolamide acyl lead compound, employing a scaffold hopping strategy. The compounds were synthesized, their structures were characterized, and they were evaluated for herbicidal activities. The results indicate that 7a exhibited exceptional herbicidal activity against Digitaria sanguinalis and Amaranthus retroflexus at a dosage of 90 g ai/ha, using the foliar spray method in a greenhouse...
March 26, 2024: Journal of Agricultural and Food Chemistry