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https://www.readbyqxmd.com/read/28320109/protective-effect-of-dexpanthenol-against-nephrotoxic-effect-of-amikacin-an-experimental-study
#1
Elif Ece Doğan, Reha Erkoç, İskender Ekinci, Jamshid Hamdard, Barış Döner, Mehmet Ali Çıkrıkçıoğlu, Cumali Karatoprak, Ganime Çoban, Ömer Faruk Özer, Rümeyza Kazancıoğlu
BACKGROUND: Amikacin has the largest spectrum among aminoglycosides, its nephrotoxic effect limits its utilization. Our purpose in this study is to review the protective effect of dexpanthenol against the nephrotoxic effect of amikacin, accompanied with histopathological and biochemical parameters. METHODS: 32 rats were randomly separated into four groups with eight in each (amikacin (1.2mg/kg/day), amikacin (1.2mg/kg/day)+dexpanthenol (500mg/kg/day), dexpanthenol (500mg/kg/day) and control)...
March 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28276605/influence-of-oral-contraceptives-on-lipid-profile-and-paraoxonase-and-commonly-hepatic-enzymes-activities
#2
Katarzyna Kowalska, Milena Ściskalska, Anna Bizoń, Mariola Śliwińska-Mossoń, Halina Milnerowicz
BACKGROUND: The aim of the study was to verify the influence of oral contraceptives (OCs) on lipid profile and the arylesterase, lactonase and phosphotriesterase activities of paraoxonase 1 (PON1). Also commonly hepatic enzymes: aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyltranspherase (GGT) were measured. METHODS: Lipid profile and hepatic enzymes were determined using commercial available reagents. Paraoxonase activities were estimated using earlier published procedures...
March 9, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28243786/daily-supplementation-with-fresh-pomegranate-juice-increases-paraoxonase-1-expression-and-activity-in-mice-fed-a-high-fat-diet
#3
D Estrada-Luna, E Martínez-Hinojosa, J C Cancino-Diaz, H Belefant-Miller, G López-Rodríguez, G Betanzos-Cabrera
PURPOSE: Studies have found that pomegranate juice (PJ) consumption increases the binding of high-density lipoproteins (HDL) to paraoxonase 1 (PON1), thus increasing the catalytic activity of this enzyme. PON1 is an antioxidant arylesterase synthesized in the liver and transported in plasma in association with HDL. Decreased levels of PON1 are associated with higher levels of cholesterol. We determined the effects of PJ on body weight, cholesterol, and triacylglycerols through 5 months of supplementation...
February 27, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28237250/a-new-arylesterase-from-pseudomonas-pseudoalcaligenes-can-hydrolyze-ionic-phthalic-polyesters
#4
Karolina Haernvall, Sabine Zitzenbacher, Motonori Yamamoto, Michael Bernhard Schick, Doris Ribitsch, Georg M Guebitz
Extracellular enzymes are assumed to be responsible for the initial and rate limiting step in biodegradation of polymers. Mainly enzymes with aliphatic esters as their natural substrates (e.g. lipase, cutinases) have until now been evaluated for polyester hydrolysis studies. However, the potential of enzymes with aromatic esters as their natural substrates (e.g. arylesterases) have been neglected although many types of polyester today contain aromatic moieties. Consequently, in order to elucidate biodegradation of phthalic polyesters in aquatic systems, a novel arylesterase (PpEst) was investigated related to hydrolysis of ionic phthalic polyesters...
February 22, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28196109/associations-between-pon1-enzyme-activities-in-human-ovarian-follicular-fluid-and-serum-specimens
#5
Keewan Kim, Michael S Bloom, Victor Y Fujimoto, Richard W Browne
The importance of high-density lipoprotein (HDL) particle components to reproduction is increasingly recognized, including the constituent paraoxonase 1 (PON1). However, the reliability characteristics of PON1 enzymes in ovarian follicular fluid (FF) as biomarkers for clinical and epidemiologic studies have not been described. Therefore, we characterized PON1 enzymes in FF and serum and assessed the impact of the PON1 Q192R polymorphism on associations between enzyme activities in two compartments. We also evaluated associations between HDL particle size and enzyme activities...
2017: PloS One
https://www.readbyqxmd.com/read/28193797/mediterranean-diet-improves-high-density-lipoprotein-function-in-high-cardiovascular-risk-individuals-a-randomized-controlled-trial
#6
Álvaro Hernáez, Olga Castañer, Roberto Elosua, Xavier Pintó, Ramón Estruch, Jordi Salas-Salvadó, Dolores Corella, Fernando Arós, Lluis Serra-Majem, Miquel Fiol, Manuel Ortega-Calvo, Emilio Ros, Miguel Ángel Martínez-González, Rafael de la Torre, M Carmen López-Sabater, Montserrat Fitó
BACKGROUND: The biological functions of high-density lipoproteins (HDLs) contribute to explaining the cardioprotective role of the lipoprotein beyond quantitative HDL cholesterol levels. A few small-scale interventions with a single antioxidant have improved some HDL functions. However, to date, no long-term, large-scale, randomized controlled trial has been conducted to assess the effects of an antioxidant-rich dietary pattern (such as a traditional Mediterranean diet [TMD]) on HDL function in humans...
February 14, 2017: Circulation
https://www.readbyqxmd.com/read/28177669/beta-sitosterol-up-regulated-paraoxonase-1-via-peroxisome-proliferator-activated-receptor-%C3%AE-in-irradiated-rats
#7
Enas Moustafa, Noura Magdy Thabet
This study was designed to evaluate the effect of Beta-sitosterol (BS) on the of peroxisome proliferator-activated receptor gamma (PPAR-γ) gene expression role in the activity of PON-1 enzyme in oxidative stress status of irradiated rats. Animals were exposed to whole body γ-radiation single dose 6Gy and received BS dose (40 mg•(kg body mass) -1•day -1, orally). In liver tissue, gene expression of PPAR-γ ligand was determined. Oxidative stress marker (malonyldialdehyde, MDA) and antioxidant enzymes activities (Superoxide dismutase; SOD Catalase; CAT, PON-1 and arylesterase; ARE) were assayed in serum and liver tissue...
January 24, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28176482/high-density-lipoprotein-associated-paraoxonase-1-activity-for-prediction-of-adverse-outcomes-in-outpatients-with-chronic-heart-failure
#8
Muhammad Hammadah, Andreas P Kalogeropoulos, Vasiliki V Georgiopoulou, Malory Weber, Yuping Wu, Stanley L Hazen, Javed Butler, W H Wilson Tang
AIMS: Decreased arylesterase (ArylE) activity of paraoxonase-1, a HDL-associated protein with anti-inflammatory and antioxidant properties, has been associated with increased risk of cardiac events in patients with ischaemic heart failure (HF). We aim to investigate the prognostic significance of changes in serum ArylE activity over time. METHODS AND RESULTS: We examined the association between baseline and follow-up serum ArylE activity and HF outcomes (death, cardiac transplantation, or ventricular assist device implantation) in 299 patients with HF enrolled in a prospective cohort study from January 2008 to July 2009, with 145 patients having available follow-up levels at 1 year...
February 7, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28167245/effects-of-paraoxonase-arylesterase-ceruloplasmin-catalase-and-myeloperoxidase-activities-on-prognosis-in-pediatric-patients-with-sepsis
#9
Ganime Ayar, Yasemin Men Atmaca, Murat Alışık, Özcan Erel
BACKGROUND: The present study aimed to investigate the levels of paraoxonase (PON), stimulated paraoxonase (SPON), arylesterase (ARE), ceruloplasmin (CLP), myeloperoxidase (MPO), and catalase (CAT) in pediatric sepsis and to explore their effects on the prognosis of sepsis. METHODS: Patients diagnosed with sepsis (n=33) and healthy controls (n=30) were included. PON, SPON, ARE, CLP, MPO, and CAT activities were measured in the sepsis and control groups. Additionally, the parameters were compared between survivors and non-survivors in the sepsis group...
February 3, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28161867/towards-understanding-the-catalytic-mechanism-of-human-paraoxonase-1-experimental-and-in-silico-mutagenesis-studies
#10
Rajan K Tripathy, Geetika Aggarwal, Priyanka Bajaj, Deepika Kathuria, Prasad V Bharatam, Abhay H Pande
Human paraoxonase 1 (h-PON1) is a ~45-kDa serum enzyme that can hydrolyze a variety of substrates, including organophosphate (OP) compounds. It is a potential candidate for the development of antidote against OP poisoning in humans. However, insufficient OP-hydrolyzing activity of native enzyme affirms the urgent need to develop improved variant(s) having enhanced OP-hydrolyzing activity. The crystal structure of h-PON1 remains unsolved, and the molecular details of how the enzyme catalyses hydrolysis of different types of substrates are also not clear...
February 4, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28090489/effect-of-short-term-high-dose-methylprednisolone-on-oxidative-stress-in-children-with-acute-immune-thrombocytopenia
#11
Musa Cura, Ahmet Koç, Nurten Aksoy, Zeynep Canan Özdemir
BACKGROUND: Immune thrombocytopenia (ITP) is the most common cause of acquired childhood thrombocytopenia and is characterized by increased immune-mediated destruction of circulating thrombocytes. Oxidative damage may be involved in ITP pathogenesis; paraoxonase (PON) and arylesterase (ARE) enzymes are closely associated with the cellular antioxidant system. We investigated the effect of short-term high-dose methylprednisolone (HDMP) treatment on the total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), and PON and ARE enzymatic activity in children with acute ITP...
December 2016: Blood Research
https://www.readbyqxmd.com/read/28000956/blood-and-semen-paraoxonase-arylesterase-activities-in-normozoospermic-and-azoospermic-men
#12
M Gulum, K Gumus, E Yeni, E Dogantekin, H Ciftci, Y Akin, M Savas, A Altunkol
Paraoxonase and arylesterase enzymes are corner stones of antioxidant defence. We aimed to compare azoospermic infertile men and normozoospermic individuals with respect to total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase and arylesterase levels in the blood and seminal plasma. Two-hundred consecutive infertility patients and voluntarily participated were included. In the normozoospermic group, TAS, PON, arylesterase values were statistically significantly higher when compared with those in the azoospermic group, while lower TOS and OSI levels were observed in the blood and seminal plasma of azoospermic group...
December 21, 2016: Andrologia
https://www.readbyqxmd.com/read/27934969/quantitative-hdl-proteomics-identifies-peroxiredoxin-6-as-a-biomarker-of-human-abdominal-aortic-aneurysm
#13
Elena Burillo, Inmaculada Jorge, Diego Martínez-López, Emilio Camafeita, Luis Miguel Blanco-Colio, Marco Trevisan-Herraz, Iakes Ezkurdia, Jesús Egido, Jean-Baptiste Michel, Olivier Meilhac, Jesús Vázquez, Jose Luis Martin-Ventura
High-density lipoproteins (HDLs) are complex protein and lipid assemblies whose composition is known to change in diverse pathological situations. Analysis of the HDL proteome can thus provide insight into the main mechanisms underlying abdominal aortic aneurysm (AAA) and potentially detect novel systemic biomarkers. We performed a multiplexed quantitative proteomics analysis of HDLs isolated from plasma of AAA patients (N = 14) and control study participants (N = 7). Validation was performed by western-blot (HDL), immunohistochemistry (tissue), and ELISA (plasma)...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872998/ppest-is-a-novel-pbat-degrading-polyesterase-identified-by-proteomic-screening-of-pseudomonas-pseudoalcaligenes
#14
Paal W Wallace, Karolina Haernvall, Doris Ribitsch, Sabine Zitzenbacher, Matthias Schittmayer, Georg Steinkellner, Karl Gruber, Georg M Guebitz, Ruth Birner-Gruenberger
A novel esterase, PpEst, that hydrolyses the co-aromatic-aliphatic polyester poly(1,4-butylene adipate-co-terephthalate) (PBAT) was identified by proteomic screening of the Pseudomonas pseudoalcaligenes secretome. PpEst was induced by the presence of PBAT in the growth media and had predicted arylesterase (EC 3.1.1.2) activity. PpEst showed polyesterase activity on both whole and milled PBAT film releasing terephthalic acid and 4-(4-hydroxybutoxycarbonyl)benzoic acid while end product inhibition by 4-(4-hydroxybutoxycarbonyl)benzoic acid was observed...
March 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27865523/alterations-in-high-density-lipoprotein-proteome-and-function-associated-with-persistent-organic-pollutants
#15
Stefan A Ljunggren, Ingela Helmfrid, Ulf Norinder, Mats Fredriksson, Gun Wingren, Helen Karlsson, Mats Lindahl
There is a growing body of evidence that persistent organic pollutants (POPs) may increase the risk for cardiovascular disease (CVD), but the mechanisms remain unclear. High-density lipoprotein (HDL) acts protective against CVD by different processes, and we have earlier found that HDL from subjects with CVD contains higher levels of POPs than healthy controls. In the present study, we have expanded analyses on the same individuals living in a contaminated community and investigated the relationship between the HDL POP levels and protein composition/function...
November 16, 2016: Environment International
https://www.readbyqxmd.com/read/27776386/evaluation-of-paraoxonase-arylesterase-and-malondialdehyde-levels-in-schizophrenia-patients-taking-typical-atypical-and-combined-antipsychotic-treatment
#16
Mehmet Güneş, Mehmet Akif Camkurt, Mahmut Bulut, Süleyman Demir, Aslıhan Okan İbiloğlu, Mehmet Cemal Kaya, Abdullah Atlı, İbrahim Kaplan, Aytekin Sir
Objective: Human serum paraoxonase (PON1) prevents lipids from peroxidation and functions as an antioxidant mechanism. Malonyldialdehyde (MDA) is the final product of lipid peroxidation and can be used as an indicator of oxidative stress. The aim of this study was to investigate PON1, MDA, and arylesterase (ARY) levels in schizophrenic patients who are taking typical, atypical, or combined (typical and atypical) antipsychotic drug treatment, with respect to those of healthy controls. Methods: We evaluated 41 patients (11 taking typical antipsychotics, 19 taking atypical antipsychotics, 11 taking combined antipsychotics) and 43 healthy controls...
November 30, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27771984/the-effects-of-adding-ischemic-preconditioning-during-desflurane-inhalation-anesthesia-or-propofol-total-intravenous-anesthesia-on-pneumoperitoneum-induced-oxidative-stress
#17
RANDOMIZED CONTROLLED TRIAL
Safinaz Karabayirli, Onder Surgit, Hulya Kasikara, Cemile Koca Bicer, Merve Ergin, Ruveyda Irem Demircioglu, Bunyamin Muslu
BACKGROUND: The aim of the study was to explore the differences in oxidative stress during anesthesia with desflurane/N2O or propofol/remifentanil in patients undergoing laparoscopic cholecystectomy and additionally to evaluate the differential effects of desflurane and propofol on ischemic preconditioning (IP). MATERIALS AND METHODS: One hundred patients were randomly allocated to four groups. For anesthesia maintenance, the inhalation group (Group I) and the inhalation plus IP group (Group IIP) received desflurane at an end-tidal concentration of 4-6 vol% in oxygen/N2O, and the TIVA group (Group T) and TIVA plus IP group (Group TIP) received infusions of propofol and remifentanil...
February 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27756946/role-of-antioxidant-property-of-carvedilol-in-mild-to-moderate-hypertensive-patients-a-prospective-open-label-study
#18
Saleh Ayashi, Ahmad Reza Assareh, Mohammad Taha Jalali, Samaneh Olapour, Hamid Yaghooti
OBJECTIVE: Carvedilol is a nonselective third generation β-blocker that does not display the negative effects of traditional β-blockers. Regarding the antioxidant, anti-inflammatory and distinct metabolic properties of carvedilol which are similar to that of high-density lipoprotein (HDL) and paraoxonase 1 (PON1), the present study intends to investigate the effects of carvedilol treatment on malondialdehyde (MDA) and soluble lectin-like ox-low-density lipoprotein (LDL) receptor (sLOX-1) as markers of oxidative stress in association to lipid profiles, apolipoproteins (apo), and PON1 activity in hypertensive patients...
July 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27716796/functional-trade-offs-in-promiscuous-enzymes-cannot-be-explained-by-intrinsic-mutational-robustness-of-the-native-activity
#19
Miriam Kaltenbach, Stephane Emond, Florian Hollfelder, Nobuhiko Tokuriki
The extent to which an emerging new function trades off with the original function is a key characteristic of the dynamics of enzyme evolution. Various cases of laboratory evolution have unveiled a characteristic trend; a large increase in a new, promiscuous activity is often accompanied by only a mild reduction of the native, original activity. A model that associates weak trade-offs with "evolvability" was put forward, which proposed that enzymes possess mutational robustness in the native activity and plasticity in promiscuous activities...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27698033/probing-the-mechanisms-for-the-selectivity-and-promiscuity-of-methyl-parathion-hydrolase
#20
Miha Purg, Anna Pabis, Florian Baier, Nobuhiko Tokuriki, Colin Jackson, Shina Caroline Lynn Kamerlin
Diverse organophosphate hydrolases have convergently evolved the ability to hydrolyse man-made organophosphates. Thus, these enzymes are attractive model systems for studying the factors shaping enzyme functional evolution. Methyl parathion hydrolase (MPH) is an enzyme from the metallo-β-lactamase superfamily, which hydrolyses a wide range of organophosphate, aryl ester and lactone substrates. In addition, MPH demonstrates metal-ion-dependent selectivity patterns. The origins of this remain unclear, but are linked to open questions about the more general role of metal ions in functional evolution and divergence within enzyme superfamilies...
November 13, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
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