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https://www.readbyqxmd.com/read/27869741/isoliquiritigenin-attenuates-atherogenesis-in-apolipoprotein-e-deficient-mice
#1
Fen Du, Quzhen Gesang, Jia Cao, Mei Qian, Li Ma, Dongfang Wu, Hong Yu
Isoliquiritigenin (ISL) exhibits antioxidation and anti-inflammation activity. We sought to investigate the effects and mechanism of ISL on the development of atherosclerotic lesions in apolipoprotein E-deficient (apoE(-/-)) mice. Firstly, we determined that ISL reduced the mRNA levels of inflammatory factors interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and monocyte chemotactic protein-1 (MCP-1), while it increased the expression of several lipoprotein-related genes in peritoneal macrophages treated with lipopolysaccharide (LPS)...
November 18, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27863895/paraoxonase-1-q192r-gene-polymorphism-coronary-heart-disease-and-the-risk-of-a-new-acute-coronary-event
#2
Efrén Martínez-Quintana, Fayna Rodríguez-González, José María Medina-Gil, Paloma Garay-Sánchez, Antonio Tugores
INTRODUCTION: Paraoxonase 1 (PON1) plays a major role in the oxidation of low density lipoprotein and in the prevention of coronary atherogenesis. In this context, coding region polymorphisms of PON1 gene, responsible for the enzyme activity, has become of interest as a marker for atherogenesis. METHODS: A study and follow-up was conducted on 529 patients with an acute coronary event in order to assess the association between the PON1 Q192R (rs662;A/G) polymorphism, the type of acute coronary syndrome, cardiovascular risk factors (arterial hypertension, diabetes mellitus, dyslipidaemia, and smoking), the extent and severity of coronary atherosclerosis, and the medium-term clinical follow-up...
November 15, 2016: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27863359/is-hyperhomocysteinemia-a-causal-factor-for-heart-failure-the-impact-of-the-functional-variants-of-mthfr-and-pon1-on-ischemic-and-non-ischemic-etiology
#3
Ewa Strauss, Wieslaw Supinski, Artur Radziemski, Grzegorz Oszkinis, Andrzej Leon Pawlak, Jerzy Gluszek
BACKGROUND: Hyperhomocysteinemia was found to be uniformly associated with the development of heart failure (HF) and HF mortality; however, it is uncertain whether this relation is causative or not. We used Mendelian randomization to examine the associations of the methylene tetrahydrofolate gene (MTHFR) and paraoxonase 1 gene (PON1) variants as a proxy for lifelong exposure to high Hcy and Hcy-thiolactone concentrations with the development of HF in men aged ≤60years and the occurrence of adverse effects at one-year follow-up...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27858903/effects-of-paraoxonase-1-gene-polymorphisms-on-heart-diseases-systematic-review-and-meta-analysis-of-64-case-control-studies
#4
Yazmín Hernández-Díaz, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, Thelma Beatriz González-Castro, Candelario Rodríguez-Pérez, María Lilia López-Narváez, José Manuel Rodríguez-Pérez, José Francisco Cámara-Álvarez
BACKGROUND: Associations between paraoxonase 1 (PON1) gene polymorphisms and heart diseases (HD) risk remain inconsistent. In order to obtain address this issue we performed a meta-analysis to assess the association between the L55M and Q192R polymorphisms of PON1 gene and heart diseases risk. METHODS: Relevant studies were enrolled by searching databases systematically. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27771368/paraoxonase-and-atherosclerosis-related-cardiovascular-diseases
#5
Dimitry A Chistiakov, Alexandra A Melnichenko, Alexander N Orekhov, Yuri V Bobryshev
In humans, three paraoxonase (PON1, PON2, and PON3) genes are clustered on chromosome 7 at a locus that spans a distance around 170 kb. These genes are highly homologous to each other and have a similar protein structural organization. PON2 is the intracellular enzyme, which is expressed in many tissues and organs, while two other members of PON gene family are produced by liver and associate with high density lipoprotein (HDL). The lactonase activity is the ancestral. Besides lactones and organic phosphates, PONs can hydrolyze and therefore detoxify oxidized low density lipoprotein and homocysteine thiolactone, i...
October 19, 2016: Biochimie
https://www.readbyqxmd.com/read/27693409/serum-paraoxonase-activity-in-relation-to-lipid-profile-in-age-related-macular-degeneration-patients
#6
Kannadasan AnandBabu, S R Bharathidevi, Sarangapani Sripriya, Parveen Sen, Vadivelu Jaya Prakash, Appukuttan Bindu, Natarajan Viswanathan, Narayanasamy Angayarkanni
Age-related Macular Degeneration (AMD) is a multifactorial disease causing visual impairment in old age. Oxidative stress is one of the main contributors for the disease progression. Paraoxonase (PON), a HDL-resident antioxidant enzyme which removes oxidized low density lipoprotein (oxLDL), which is not studied much in AMD. This study assesses the PON activities in relation to the lipid status and genetic variants in AMD patients. In this prospective case-control study, a total of 48 AMD patients and 30 unrelated healthy controls were recruited...
September 28, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27668323/association-of-paraoxonase-1-pon1-gene-polymorphisms-and-concentration-with-essential-hypertension
#7
Didem Turgut Cosan, E Colak, F Saydam, H U Yazıcı, I Degirmenci, A Birdane, E Colak, H V Gunes
Human serum paraoxonase 1 (PON1) is carried by high-density lipoprotein in blood circulation and is shown to be effective in preventing oxidized phospholipids carried by low-density lipoprotein particles, thus it acts as an antioxidant. Polymorphism in this gene has been investigated for many metabolic diseases, but it is not thought to be a genetic risk factor for essential hypertension. The aim of this study was to determine whether there was an association between PON1 gene polymorphisms and concentration with essential hypertension...
2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27642496/a%C3%A3-ai-euterpe-oleracea-mart-upregulates-paraoxonase-1-gene-expression-and-activity-with-concomitant-reduction-of-hepatic-steatosis-in-high-fat-diet-fed-rats
#8
Renata Rebeca Pereira, Isabel Cristina Mallosto Emerich de Abreu, Joyce Ferreira da Costa Guerra, Nara Nunes Lage, Juliana Márcia Macedo Lopes, Maísa Silva, Wanderson Geraldo de Lima, Marcelo Eustáquio Silva, Maria Lucia Pedrosa
Açai (Euterpe oleracea Mart.), a fruit from the Amazon region, has emerged as a promising source of polyphenols. Açai consumption has been increasing owing to ascribed health benefits and antioxidant properties; however, its effects on hepatic injury are limited. In this study, we evaluated the antioxidant effect of filtered açai pulp on the expression of paraoxonase (PON) isoforms and PON1 activity in rats with nonalcoholic fatty liver disease (NAFLD). The rats were fed a standard AIN-93M (control) diet or a high-fat (HF) diet containing 25% soy oil and 1% cholesterol with or without açai pulp (2 g/day) for 6 weeks...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27640339/paraoxonase-1-gene-polymorphisms-and-enzyme-activities-in-coronary-artery-disease-and-its-relationship-to-serum-lipids-and-glycemia
#9
Osvaldo Fridman, Luis Gariglio, Stephanie Riviere, Rafael Porcile, Alicia Fuchs, Miguel Potenzoni
OBJECTIVES: Oxidative stress and inflammation are important processes in development of atherosclerosis. Paraoxonase 1 (PON1) is a bioscavenger enzyme associated with inflammation and oxidative stress. We evaluate the association of two single nucleotide polymorphisms in PON1 gene, and enzyme activities with lipid profile and glycemia. METHODS: This case-control study consisted of 126 patients with coronary artery disease (CAD) and 203 healthy controls. PON Q192R and L55M polymorphisms were detected by real-time PCR...
September 15, 2016: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/27633038/pharmacological-interactions-of-paraoxonase-1-pon1-a-hdl-bound-antiatherogenic-enzyme
#10
Abdolkarim Mahrooz
A growing interest exists in documenting the role of paraoxonase 1 (PON1) in different human diseases including, cardiovascular disease, obesity, diabetes mellitus, cancers, aging, and several neurological disorders. Three aspects of PON1 has attracted the attention of researchers: (1) hydrolyzing and detoxifying of toxic organophosphorous compounds such as nerve gases; (2) antioxidative activity in hydrolyzing oxidized phospholipids in high-density lipoprotein (HDL) and low-density lipoprotein (LDL); (3) interaction with various drugs...
September 15, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27591364/dysfunctional-hdl-in-acute-stroke
#11
Guadalupe Ortiz-Munoz, David Couret, Bertrand Lapergue, Eric Bruckert, Elena Meseguer, Pierre Amarenco, Olivier Meilhac
BACKGROUND AND AIMS: HDL-cholesterol concentration is a reliable negative risk factor for acute cerebral infarction (ACI). Beyond quantitative aspects, our aim was to determine whether lipoprotein profiles and HDL functionality were altered at the acute phase of ischemic stroke. METHODS: Blood was taken from ACI patients within 4.5 h of symptom onset. Lipoproteins were separated by electrophoresis for determination of particle size. HDLs were isolated from plasma of patients (n = 10) and controls (n = 10) by ultracentrifugation...
October 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27578362/human-paraoxonase-gene-cluster-overexpression-alleviates-angiotensin-ii-induced-cardiac-hypertrophy-in-mice
#12
Jian-Fei Pei, Yun-Fei Yan, Xiaoqiang Tang, Yang Zhang, Shen-Shen Cui, Zhu-Qin Zhang, Hou-Zao Chen, De-Pei Liu
Cardiac hypertrophy is the strongest predictor of the development of heart failure, and anti-hypertrophic treatment holds the key to improving the clinical syndrome and increasing the survival rates for heart failure. The paraoxonase (PON) gene cluster (PC) protects against atherosclerosis and coronary artery diseases. However, the role of PC in the heart is largely unknown. To evaluate the roles of PC in cardiac hypertrophy, transgenic mice carrying the intact human PON1, PON2, and PON3 genes and their flanking sequences were studied...
August 30, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27520507/antibodies-to-paraoxonase-1-are-associated-with-oxidant-status-and-endothelial-activation-in-rheumatoid-arthritis
#13
Javier Rodríguez-Carrio, Mercedes Alperi-López, Raquel López-Mejías, Patricia López, Francisco J Ballina-García, Francisco Abal, Miguel Á González-Gay, Ana Suárez
Traditional and non-traditional cardiovascular (CV) risk factors underlie CV disease occurrence in rheumatoid arthritis (RA). Recently, a functional impairment of high-density lipoprotein (HDL) has been observed. Although the actual players are unknown, anti-HDLs were associated with altered lipid profile, decreased paraoxonase 1 (PON1) activity and CV disease in RA. Therefore, we aimed to evaluate whether the presence of antibodies against PON1 may be involved in this scenario. IgG anti-PON1 antibodies were quantified by ELISA in serum samples from 212 RA patients, 175 healthy controls (HC) and 54 subjects with traditional CV risk factors (CVR)...
November 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27453486/exogenous-paraoxonase-1-during-oocyte-maturation-improves-bovine-embryo-development-in-vitro
#14
Jaa Rincón, E M Madeira, F T Campos, B Mion, J F Silva, V A Absalón-Medina, W R Butler, M N Corrêa, Lmc Pegoraro, A Schneider
Paraoxonase-1 (PON1) is an enzyme found in serum and follicular fluid that protects cell membrane and circulating lipids against oxidative damage. The aims of this study were to measure the direct effects of recombinant PON1 (rPON1) on bovine oocyte maturation at the molecular level (gene expression) and to measure the carry-over effects of PON1 on pre-implantation embryo development in vitro. COCs were submitted to IVM with the addition of 0.0, 0.02, 0.04 and 0.08 mg ml(-1) of rPON1, corresponding to an average PON1 arylesterase enzyme activity of 2...
October 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27450784/relationship-of-paraoxonase-1-q192r-genotypes-and-in-stent-restenosis-and-re-stenting-in-chinese-patients-after-coronary-stenting
#15
Wenfang Ma, Yan Liang, Jun Zhu, Tao Chen, Guangxun Feng, Yanmin Yang, Xin Liu, Xingyu Wang
BACKGROUND AND AIMS: Asians have very different genotype distributions of cytochrome P450 2C19 (CYP2C19), ATP-binding cassette, sub-family B, member 1 (ABCB1), and paraoxonase-1 (PON1), in whom relevant studies based on large samples are scarce. The purpose of this study was to evaluate the effects of these genes on outcomes of in-stent restenosis and re-stenting in Chinese patients after coronary stenting. METHODS: A total of 2569 acute coronary syndrome (ACS) patients were enrolled in a gene database study...
August 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27437027/anesthetic-propofol-induced-gene-expression-changes-in-patients-undergoing-coronary-artery-bypass-graft-surgery-based-on-dynamical-differential-coexpression-network-analysis
#16
Da Yu, Li-Jun Huang, Na-Mi Chen
We aimed to determine the influence of anesthetic propofol on gene expression in patients treated by coronary artery bypass graft (CABG) surgery based on differential coexpression network (DCN) and to further reveal the novel mechanisms of the cardioprotective effects of propofol. Firstly, we constructed the DCN for disease condition based on Pearson correlation coefficient (PCC) and weight value. Secondly, the inference of modules was applied to search modules from DCN with same members but varied connectivity...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/27380588/cyp2c19-but-not-cyp2b6-cyp3a4-cyp3a5-abcb1-pon1-or-p2y12-genetic-polymorphism-impacts-antiplatelet-response-after-clopidogrel-in-koreans
#17
Hong-Zhe Zhang, Moo Hyun Kim, Long-Zhe Guo, Victor Serebruany
Clopidogrel response variability (CRV) is well documented, and may affect clinical outcomes. Impact of genetic polymorphisms is important for assessing and predicting CRV. The extensive evidence indicates the importance of CYP2C19 variants in reducing efficacy of clopidogrel. This study defined the impact of numerous genetic polymorphisms on CRV before and after percutaneous coronary interventions (PCI) exclusively in a Korean cohort assuming less genetic variability noise. One hundred and thirty-six patients of Korean origin undergoing PCI were included...
July 1, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/27350664/effect-of-genetic-and-coexisting-polymorphisms-on-platelet-response-to-clopidogrel-in-chinese-han-patients-with-acute-coronary-syndrome
#18
Xu Liu, Yu Luo, Yan Lai, Yian Yao, Jimin Li, Yunkai Wang, S Lilly Zheng, Jianfeng Xu, Xuebo Liu
Polymorphisms of CYP2C19 are associated with platelet response to clopidogrel. This study was conducted to evaluate the contribution of the previously identified polymorphisms to the response of clopidogrel in a cohort of Chinese Han patients. A total of 222 acute coronary syndrome patients undergoing percutaneous coronary intervention treated with clopidogrel were enrolled from September 2012 to June 2013. Residual platelet aggregations for all patients were measured by the Verify Now P2Y12 system. Sixteen single-nucleotide polymorphisms among nine genes were genotyped including CYP2C19, ABCB1 and PON1...
June 2016: Journal of Genetics
https://www.readbyqxmd.com/read/27338244/interaction-between-polyphenols-intake-and-pon1-gene-variants-on-markers-of-cardiovascular-disease-a-nutrigenetic-observational-study
#19
Federica Rizzi, Costanza Conti, Elena Dogliotti, Annalisa Terranegra, Erika Salvi, Daniele Braga, Flavia Ricca, Sara Lupoli, Alessandra Mingione, Francesca Pivari, Caterina Brasacchio, Matteo Barcella, Martina Chittani, Francesca D'Avila, Maurizio Turiel, Monica Lazzaroni, Laura Soldati, Daniele Cusi, Cristina Barlassina
BACKGROUND: Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the interaction between these factors remains to be investigated. We performed an observational nutrigenetic study to examine whether the interaction between polyphenols and anthocyanins intake and PON1 genetic variants can modulate biomarkers of cardiovascular health in an Italian healthy population...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27325068/paraoxonase-1-and-early-life-environmental-exposures
#20
REVIEW
Judit Marsillach, Lucio G Costa, Clement E Furlong
Acute and chronic exposures to widely used organophosphorus (OP) insecticides are common. Children's detoxification mechanisms are not well developed until several years after birth. The increased cases of neurodevelopmental disorders in children, together with their increased susceptibility to OP neurotoxicity cannot be explained by genetic factors alone but could be related to gene-environment interactions. Paraoxonase-1 (PON1) is an enzyme that can detoxify OPs but its catalytic efficiency for hydrolysis to certain OPs is modulated by the Q192R polymorphism...
January 2016: Annals of Global Health
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