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PON1 gene

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https://www.readbyqxmd.com/read/29747151/role-of-pon1-sod2-ogg1-xrcc1-and-xrcc4-polymorphisms-on-modulation-of-dna-damage-in-workers-occupationally-exposed-to-pesticides
#1
Vivian F Silva Kahl, Fernanda Rabaioli da Silva, Jodel da Silva Alves, Gabrieli Flesch da Silva, Juliana Picinini, Varinderpal Singh Dhillon, Michael Fenech, Melissa Rosa de Souza, Johnny F Dias, Claudia Telles de Souza, Mirian Salvador, Cátia Dos Santos Branco, Flávia Valadão Thiesen, Daniel Simon, Juliana da Silva
Tobacco farming has been proving to induce poor health outcomes in agricultural workers, genomic instability being the triggering one. This study evaluated influence of PON1 (paraoxonase 1), SOD2 (superoxide dismutase), OGG1 (8-oxoguanine glycosylase), XRCC1 (X-ray repair cross-complementing protein 1), and XRCC4 (X-ray repair cross-complementing protein 4) genes polymorphisms on DNA damage in 121 subjects occupationally exposed to pesticides mixtures and nicotine at tobacco fields and 121 non-exposed individuals...
May 7, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29682786/the-evaluation-of-two-genetic-polymorphisms-of-paraoxonase-1-in-patients-with-pulmonary-embolism
#2
Nursah Basol, Nevin Karakus, Asli Yasemen Savas, Kayhan Karakus, İlker Kaya, Serhat Karaman, Serbulent Yigit
BACKGROUND AND OBJECTIVE: Pulmonary embolism (PE) is caused by some genetic factors for more than half patients. Paraoxonase 1 (PON1) has significant anti-oxidative and anti-inflammatory effects. According to our knowledge, there is no study researching the relation between PON 1 gene polymorphisms and PE in the literature. Therefore, it is aimed to research possible impacts of PON 1 Q192R and L55M polymorphisms on PE, considering anti-inflammatory and anti-oxidative effects of PON 1 in Turkish population...
April 22, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29604466/pon1-promoter-polymorphisms-contribute-to-pcos-susceptibility-and-phenotypic-outcomes-in-indian-women
#3
Roshan Dadachanji, Nuzhat Shaikh, Anushree Patil, Nalini Shah, Srabani Mukherjee
Polycystic ovary syndrome is a common endocrinopathy characterized by anovulatory infertility, hyperandrogenism, insulin resistance and oxidative stress, which predisposes affected women to reproductive and cardiometabolic complications in later life. We have investigated the association of PON1 promoter polymorphisms with PCOS susceptibility, PON1 activity and its related traits in Indian women. The genotypic and allelic frequency distribution of only -907G/C polymorphism in PON1 promoter showed significant difference between non-hyperandrogenic control and PCOS women, and was significantly associated with reduced susceptibility to PCOS, considering the recessive model...
March 28, 2018: Gene
https://www.readbyqxmd.com/read/29564841/role-of-genetic-background-in-cardiovascular-risk-markers-changes-in-water-polo-players
#4
Debora Di Mauro, Monica Currò, Fabio Trimarchi, Mercurio Vecchio, Giuseppina Rizzo, Davide Barreca, Giuseppa Visalli, Riccardo Ientile, Daniela Caccamo
Methylene-tetrahydrofolate reductase (MTHFR) and paraoxonase 1 (PON1) gene polymorphisms have been associated with hyperhomocysteinemia and oxidative stress increase, that are established cardiovascular risk factors. Given that intense physical activity may increase the susceptibility to adverse cardiovascular outcomes, here we investigated the effects of MTHFR C677T and A1298C as well as PON1 Q192R gene polymorphisms on cardiovascular risk markers in twenty-eight male water polo elite players. The mean plasma levels of homocysteine (Hcy) and advanced oxidation protein products (AOPP) were above reference limits in resting conditions, and increased after competition...
March 21, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29546656/association-of-pon1-gene-polymorphisms-with-polycystic-ovarian-syndrome-risk-a-meta-analysis-of-case-control-studies
#5
D Liao, H Yu, L Han, C Zhong, X Ran, D Wang, L Mo
PURPOSE: Evidences showed that paraoxonase 1 (PON1) gene polymorphism has an impact on women's susceptibility to polycystic ovarian syndrome (PCOS) by influencing the expression and activity of PON1. However, the effects of three PON1 polymorphisms (- 108 C>T, L55M and Q192R) on the incidence of PCOS have generated inconsistent results. Here, we conducted a meta-analysis to investigate the association between PON1 polymorphisms and PCOS risk. METHODS: All eligible trials were identified via systematic searches of multiple literature databases...
March 15, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29462797/functional-snp-in-the-3-utr-of-pon1-is-associated-with-the-risk-of-calcific-aortic-valve-stenosis-via-mir-616
#6
Zhengjun Wang, Shiqiao Chen, Mei Zhu, Wenlong Zhang, Haizhou Zhang, Hongxin Li, Chengwei Zou
BACKGROUND/AIMS: Previous studies have examined the associations between the single nucleotide polymorphism in the Paraoxonase 1 (PON1) gene and development of calcific aortic valve stenosis (CAVS). The association between functional SNP in 3'UTR of PON1 and the risk of CAVS, however, is unclear. In this study, we investigated the role of SNP in the regulation of PON1 expression via miR-616, as well as the association of SNP with the risk of CAVS. METHODS: Two hundred and sixteen patients with CAVS and 243 CAVS-free participants were recruited in this study...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29459363/the-failing-heart-stimulates-tumor-growth-by-circulating-factors
#7
Wouter C Meijers, Manuel Maglione, Stephan J L Bakker, Rupert Oberhuber, Lyanne M Kieneker, Steven de Jong, Bernhard J Haubner, Wouter B Nagengast, Alexander R Lyon, Bert van der Vegt, Dirk J van Veldhuisen, B Daan Westenbrink, Peter van der Meer, Herman H W Silljé, Rudolf A de Boer
Background -Heart failure (HF) survival has improved and nowadays many patients with HF die from non-cardiac causes, including cancer. Our aim was to investigate whether a causal relationship exists between HF and the development of cancer. Methods -HF was induced by inflicting large anterior myocardial infarction (MI) in APCmin mice, which are prone to develop precancerous intestinal tumors, and tumor growth was measured. In addition, to rule out hemodynamic impairment, a heterotopic heart transplantation model was employed, where an infarcted or sham-operated heart was transplanted into a recipient mouse, while the native heart was left in situ...
February 19, 2018: Circulation
https://www.readbyqxmd.com/read/29411531/aspirin-and-clopidogrel-high-on-treatment-platelet-reactivity-and-genetic-predictors-in-peripheral-arterial-disease
#8
Khung-Keong Yeo, Ehrin J Armstrong, Javier E López, Debbie C Chen, Gregory G Westin, Chin-Shang Li, David Anderson, Amy Hua, Anil Singapuri, Ezra A Amsterdam, Nipavan Chiamvimonvat, John R Laird
OBJECTIVES: Our aims were to examine the prevalence and genetic predictors of aspirin and clopidogrel high on-treatment platelet reactivity (HoTPR), and associated adverse cardiovascular outcomes in patients with peripheral arterial disease (PAD). BACKGROUND: The association of aspirin and clopidogrel HoTPR with outcomes in PAD remains unclear. METHODS: This is a prospective cohort study of patients with angiographically documented PAD involving carotid and lower extremity arteries...
February 7, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29409844/association-of-paraoxonase-1-gene-polymorphisms-with-insulin-resistance-in-south-indian-population
#9
Panneerselvam Gomathi, Anandi Chandramouli Iyer, Ponniah Senthil Murugan, Sundaresan Sasikumar, Nancy Bright Arul Joseph Raj, Divya Ganesan, Sivagnanam Nallaperumal, Maruthamuthu Murugan, Govindan Sadasivam Selvam
BACKGROUND AND AIM: Insulin resistance plays a crucial role in the pathogenesis of type 2 diabetes and cardiovascular diseases. Recently, paraoxonase-1(PON1) is reported to have an ability to reduce insulin resistance by promoting glucose transporter-4 (GLUT-4) expression in vitro. Single nucleotide polymorphism (SNP) in PON1 is associated with variability in enzyme activity and concentration. Based on this we aimed to investigate the association of PON1 (Q192R and L55M) polymorphisms with the risk of developing insulin resistance in adult South Indian population...
April 15, 2018: Gene
https://www.readbyqxmd.com/read/29404631/new-mechanistic-insights-on-the-metabolic-disruptor-role-of-chlorpyrifos-in-apoe-mice-a-focus-on-insulin-and-leptin-signalling-pathways
#10
Fiona Peris-Sampedro, Jordi Blanco, Maria Cabré, Pia Basaure, Laia Guardia-Escote, Jose L Domingo, Domènec J Sánchez, Maria Teresa Colomina
Recently, we have provided evidence, suggesting that mice expressing the human apolipoprotein E3 (apoE3) are more prone to develop an obesity-like phenotype and a diabetic profile when subchronically fed a chlorpyrifos (CPF)-supplemented diet. The aim of the current study was to examine the underlying mechanisms through which CPF alters both insulin- and leptin-signalling pathways in an APOE-dependent manner. Both adult apoE3- and E4-targeted replacement and C57BL/6 mice were exposed to CPF at 0 or 2 mg/kg body weight/day through the diet for 8 consecutive weeks...
February 5, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29397664/genotype-phenotype-analysis-of-paraoxonase-1-in-schizophrenic-patients-treated-with-atypical-antipsychotics
#11
Denis Pavăl, Bogdan Nemeș, Răzvan L Rusu, Eleonora Dronca
Objective: Recent studies suggest a possible involvement of low paraoxonase 1 (PON1) enzyme activities in the association between schizophrenia, treatment with atypical antipsychotics and increased cardiovascular (CVD) risk. In the present study, we aimed at investigating the PON1 status in a group of schizophrenic patients treated with either olanzapine or other antipsychotic, as compared to a group of healthy control participants. Methods: We assessed the arylesterase (AREase) and paraoxonase (POase) activities of PON1, as well as three common polymorphisms of PON1 gene (Q192R, L55M, -108C>T)...
February 28, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29395491/epistasis-analysis-of-metabolic-genes-polymorphisms-associated-with-ischemic-heart-disease-in-yucatan
#12
Igrid García-González, Roger Iván López-Díaz, José Reyes Canché-Pech, Alberto de Jesús Solís-Cárdenas, Jorge A Flores-Ocampo, Renán Mendoza-Alcocer, Luis Fernando Herrera-Sánchez, Marco Antonio Jiménez-Rico, Adrián Alejandro Ceballos-López, María E López-Novelo
OBJECTIVE: Epistasis is a type of genetic interaction that could explain much of the phenotypic variability of complex diseases. In this work, the effect of epistasis of metabolic genes and cardiovascular risk on the susceptibility to the development of ischemic heart disease in Yucatan was determined. METHODS: Case-control study in 79 Yucatecan patients with ischemic heart disease and 101 healthy controls matched by age and origin with cases. The polymorphisms -108CT, Q192R, L55M (paraoxonase 1; PON1), C677T, A1298C (methylenetetrahydrofolate reductase; MTHFR), and the presence/absence of the glutathione S-transferase T1 (GSTT1) gene were genotyped...
January 28, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29383019/alteration-of-hepatocellular-antioxidant-gene-expression-pattern-and-biomarkers-of-oxidative-damage-in-diazinon-induced-acute-toxicity-in-wistar-rat-a-time-course-mechanistic-study
#13
Shokoufeh Hassani, Faheem Maqbool, Armin Salek-Maghsoudi, Soheila Rahmani, Amir Shadboorestan, Amir Nili-Ahmadabadi, Mohsen Amini, Parviz Norouzi, Mohammad Abdollahi
In the present survey, the plasma level of diazinon after acute exposure was measured by HPLC method at a time-course manner. In addition, the impact of diazinon on the expression of the key genes responsible for hepatocellular antioxidative defense, including PON1, GPx and CAT were investigated. The increase in oxidative damages in treated rats was determined by measuring LPO, protein carbonyl content and total antioxidant power in plasma. After administration of 85 mg/kg diazinon in ten groups of male Wistar rats at different time points between 0-24 hours, the activity of AChE enzyme was inhibited to about 77...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29273831/synergism-between-apolipoprotein-e-%C3%A6-4-allele-and-paraoxonase-pon1-55-m-allele-is-associated-with-risk-of-systemic-lupus-erythematosus
#14
Maryam Tanhapour, Ali Miri, Asad Vaisi-Raygani, Fariborz Bahrehmand, Amir Kiani, Zohreh Rahimi, Tayebeh Pourmotabbed, Ebrahim Shakiba
Evidences indicate that abnormal lipid metabolism and lipid peroxidation can affect the progression of complications in systemic lupus erythematosus (SLE) patients. Apolipoprotein E (ApoE) and paraoxonase-1 (PON1) play important role in lipid metabolism and protection of lipid peroxidation. The polymorphisms of ApoE and paraoxonase (PON1) L55M (Met < Leu) allele genes lead to disorders in lipid metabolism and are related to atherosclerosis. This study is the first investigation to examine the possible association between ApoE and PON1-L55M polymorphisms and correlation with serum arylesterase (ARE) activities of PON, levels of malondialdehyde (MDA), neopterin, and lipid lipoprotein in SLE patients from Iranian western population...
December 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29233102/the-gene-treatment-interaction-of-paraoxonase-1-gene-polymorphism-and-statin-therapy-on-insulin-secretion-in-japanese-patients-with-type-2-diabetes-fukuoka-diabetes-registry
#15
MULTICENTER STUDY
Akiko Sumi, Udai Nakamura, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Yuji Komorita, Masahito Yoshinari, Yoichiro Hirakawa, Atsushi Hirano, Michiaki Kubo, Takanari Kitazono
BACKGROUND: Although statins deteriorate glucose metabolism, their glucose-lowering effects have emerged in some situations. Here, we assessed whether these effects are a consequence of statins' interaction with paraoxonase (PON)1 enzyme polymorphism. METHODS: Adult Japanese type 2 diabetes patients (n = 3798) were enrolled in a cross-sectional study. We used Q192R polymorphism of the PON1 gene as a representative single-nucleotide polymorphism and focused on the effects of the wild-type Q allele, in an additive manner...
December 12, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29229890/q192r-polymorphism-in-the-pon1-gene-and-familial-hypercholesterolemia-in-a-saudi-population
#16
Khalid Khalaf Alharbi, May Salem Alnbaheen, Fawiziah Khalaf Alharbi, Rana M Hasanato, Imran Ali Khan
BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal dominant condition characterized by abnormal levels of low-density lipoprotein (LDL) in the blood. FH is a risk factor for atherosclerosis and cardiovascular disease. The relationship between the paraoxonase 1 (PON1) gene, atherosclerosis and coronary artery disease has not been studied in Saudi patients. OBJECTIVE: To investigate the genetic associations of the Q192R polymorphism in the PON1 gene with FH in Saudi patients...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29226640/association-of-paraoxonase-1-polymorphism-and-serum-25-hydroxyvitamin-d-with-the-risk-of-cardiovascular-disease-in-patients-with-rheumatoid-arthritis
#17
Sawsan O Khoja, Yasser El Miedany, Archana P Iyer, Sami M Bahlas, Khadijah S Balamash, Mohamed F Elshal
BACKGROUND: Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality that are not accounted for by traditional risk factors alone. Paraoxonase 1 (PON1) and 25-hydroxyvitamin D have been shown to be involved in the pathogenesis of CV diseases. Objective: This study aimed to investigate PON1 gene polymorphism and serum 25-hydroxyvitamin D concentrations in RA patients, and to determine their association with CV risk in RA. METHODS: Serum samples from 46 RA patients and 45 healthy controls were tested for PON1 R192Q genotypes and serum vitamin D concentrations...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29215590/joint-effects-of-pon1-polymorphisms-and-vegetable-intake-on-ischemic-stroke-a-family-based-case-control-study
#18
Juan Juan, Xia Jiang, Xun Tang, Yiqun Wu, Kexin Sun, Xiao Xiang, Yaohua Tian, Tao Wu, Qi Sun, Peter Kraft, Yonghua Hu
Paraoxonase 1 gene ( PON1 ) polymorphisms and dietary vegetable and fruit intake are both established determinants of ischemic stroke (IS). However, little is known about whether these factors jointly influence the risk of IS. We analyzed the main effects of PON1 , as well as the interactions between PON1 and dietary vegetable or fruit intake with the risk of total IS and its subtypes in a family-based case-control study conducted among 2158 Chinese participants (1007 IS cases and 1151 IS-free controls) from 918 families...
December 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29199478/effect-of-certain-non-steroidal-anti-inflammatory-drugs-on-the-paraoxonase-2-pon2-in-human-monocytic-cell-line-u937
#19
Ayla Solmaz Avcıkurt, Oğuzhan Korkut
The paraoxonase gene family in humans consists of three members as PON1, PON2 and PON3. PON2 can be expressed in several tissues; however, it is not released from the cells in those tissues. PON2 is also expressed in macrophages. Firstly, the commonly used NSAIDs diclofenac sodium and tenoxicam were applied on U937 cell line, the in vitro human monocyte cell line. Than PON2 specific Lactonase activity and paraoxonase family specific arylesterase were determined. Use of Diclofenac sodium in 0.845 mM dose during 6-12 h of incubation and Tenoxicam in 0...
December 3, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29170064/the-role-of-paraoxonase-in-cancer
#20
REVIEW
Tiziana Bacchetti, Gianna Ferretti, Amirhossein Sahebkar
The paraoxonase (PON) gene family includes three proteins, PON1, PON2 and PON3. PON1 and PON3 are both associated with high-density lipoprotein (HDL) particles and exert anti-oxidant and anti-inflammatory properties. PON2 and PON3 are intracellular enzymes which modulate mitochondrial superoxide anion production and endoplasmic reticulum (ER) stress-induced apoptosis. The pleiotropic roles exerted by PONs have been mainly investigated in cardiovascular and neurodegenerative diseases. In recent years, overexpression of PON2 and PON3 has been observed in cancer cells and it has been proposed that both enzymes could be involved in tumor survival and stress resistance...
November 21, 2017: Seminars in Cancer Biology
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