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PON1 gene

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https://www.readbyqxmd.com/read/29273831/synergism-between-apolipoprotein-e-%C3%A6-4-allele-and-paraoxonase-pon1-55-m-allele-is-associated-with-risk-of-systemic-lupus-erythematosus
#1
Maryam Tanhapour, Ali Miri, Asad Vaisi-Raygani, Fariborz Bahrehmand, Amir Kiani, Zohreh Rahimi, Tayebeh Pourmotabbed, Ebrahim Shakiba
Evidences indicate that abnormal lipid metabolism and lipid peroxidation can affect the progression of complications in systemic lupus erythematosus (SLE) patients. Apolipoprotein E (ApoE) and paraoxonase-1 (PON1) play important role in lipid metabolism and protection of lipid peroxidation. The polymorphisms of ApoE and paraoxonase (PON1) L55M (Met < Leu) allele genes lead to disorders in lipid metabolism and are related to atherosclerosis. This study is the first investigation to examine the possible association between ApoE and PON1-L55M polymorphisms and correlation with serum arylesterase (ARE) activities of PON, levels of malondialdehyde (MDA), neopterin, and lipid lipoprotein in SLE patients from Iranian western population...
December 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29233102/the-gene-treatment-interaction-of-paraoxonase-1-gene-polymorphism-and-statin-therapy-on-insulin-secretion-in-japanese-patients-with-type-2-diabetes-fukuoka-diabetes-registry
#2
Akiko Sumi, Udai Nakamura, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Yuji Komorita, Masahito Yoshinari, Yoichiro Hirakawa, Atsushi Hirano, Michiaki Kubo, Takanari Kitazono
BACKGROUND: Although statins deteriorate glucose metabolism, their glucose-lowering effects have emerged in some situations. Here, we assessed whether these effects are a consequence of statins' interaction with paraoxonase (PON)1 enzyme polymorphism. METHODS: Adult Japanese type 2 diabetes patients (n = 3798) were enrolled in a cross-sectional study. We used Q192R polymorphism of the PON1 gene as a representative single-nucleotide polymorphism and focused on the effects of the wild-type Q allele, in an additive manner...
December 12, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29229890/q192r-polymorphism-in-the-pon1-gene-and-familial-hypercholesterolemia-in-a-saudi-population
#3
Khalid Khalaf Alharbi, May Salem Alnbaheen, Fawiziah Khalaf Alharbi, Rana M Hasanato, Imran Ali Khan
BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal dominant condition characterized by abnormal levels of low-density lipoprotein (LDL) in the blood. FH is a risk factor for atherosclerosis and cardiovascular disease. The relationship between the paraoxonase 1 (PON1) gene, atherosclerosis and coronary artery disease has not been studied in Saudi patients. OBJECTIVE: To investigate the genetic associations of the Q192R polymorphism in the PON1 gene with FH in Saudi patients...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29226640/association-of-paraoxonase-1-polymorphism-and-serum-25-hydroxyvitamin-d-with-the-risk-of-cardiovascular-disease-in-patients-with-rheumatoid-arthritis
#4
Sawsan O Khoja, Yasser El Miedany, Archana P Iyer, Sami M Bahlas, Khadijah S Balamash, Mohamed F Elshal
BACKGROUND: Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality that are not accounted for by traditional risk factors alone. Paraoxonase 1 (PON1) and 25-hydroxyvitamin D have been shown to be involved in the pathogenesis of CV diseases. Objective: This study aimed to investigate PON1 gene polymorphism and serum 25-hydroxyvitamin D concentrations in RA patients, and to determine their association with CV risk in RA. METHODS: Serum samples from 46 RA patients and 45 healthy controls were tested for PON1 R192Q genotypes and serum vitamin D concentrations...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29215590/joint-effects-of-pon1-polymorphisms-and-vegetable-intake-on-ischemic-stroke-a-family-based-case-control-study
#5
Juan Juan, Xia Jiang, Xun Tang, Yiqun Wu, Kexin Sun, Xiao Xiang, Yaohua Tian, Tao Wu, Qi Sun, Peter Kraft, Yonghua Hu
Paraoxonase 1 gene (PON1) polymorphisms and dietary vegetable and fruit intake are both established determinants of ischemic stroke (IS). However, little is known about whether these factors jointly influence the risk of IS. We analyzed the main effects of PON1, as well as the interactions between PON1 and dietary vegetable or fruit intake with the risk of total IS and its subtypes in a family-based case-control study conducted among 2158 Chinese participants (1007 IS cases and 1151 IS-free controls) from 918 families...
December 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29199478/effect-of-certain-non-steroidal-anti-inflammatory-drugs-on-the-paraoxonase-2-pon2-in-human-monocytic-cell-line-u937
#6
Ayla Solmaz Avcıkurt, Oğuzhan Korkut
The paraoxonase gene family in humans consists of three members as PON1, PON2 and PON3. PON2 can be expressed in several tissues; however, it is not released from the cells in those tissues. PON2 is also expressed in macrophages. Firstly, the commonly used NSAIDs diclofenac sodium and tenoxicam were applied on U937 cell line, the in vitro human monocyte cell line. Than PON2 specific Lactonase activity and paraoxonase family specific arylesterase were determined. Use of Diclofenac sodium in 0.845 mM dose during 6-12 h of incubation and Tenoxicam in 0...
December 3, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29170064/the-role-of-paraoxonase-in-cancer
#7
REVIEW
Tiziana Bacchetti, Gianna Ferretti, Amirhossein Sahebkar
The paraoxonase (PON) gene family includes three proteins, PON1, PON2 and PON3. PON1 and PON3 are both associated with high-density lipoprotein (HDL) particles and exert anti-oxidant and anti-inflammatory properties. PON2 and PON3 are intracellular enzymes which modulate mitochondrial superoxide anion production and endoplasmic reticulum (ER) stress-induced apoptosis. The pleiotropic roles exerted by PONs have been mainly investigated in cardiovascular and neurodegenerative diseases. In recent years, overexpression of PON2 and PON3 has been observed in cancer cells and it has been proposed that both enzymes could be involved in tumor survival and stress resistance...
November 20, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29118461/relationship-between-rs854560-pon1-gene-polymorphism-and-tobacco-smoking-with-coronary-artery-disease
#8
Joanna Iwanicka, Tomasz Iwanicki, Paweł Niemiec, Tomasz Nowak, Jolanta Krauze, Władysław Grzeszczak, Sylwia Górczyńska-Kosiorz, Anna Ochalska-Tyka, Iwona Żak
Paraoxonase-1 (PON1) is the antioxidant marker of high-density lipoproteins protecting against atherosclerosis and coronary artery disease (CAD) phenotype. The purpose of the present study was to determine whether the PON1 gene rs854560 polymorphism (163T>A) is associated with CAD in Polish population. rs854560 was genotyped in 494 subjects: 248 patients with premature CAD and 246 blood donors as a control. We found that the risk of CAD was significantly higher in TT homozygotes than in A allele carriers (OR = 1...
2017: Disease Markers
https://www.readbyqxmd.com/read/29063603/effects-of-paraoxonase-1-on-the-cytodifferentiation-and-mineralization-of-periodontal-ligament-cells
#9
R Masumoto, J Kitagaki, M Matsumoto, S Miyauchi, C Fujihara, M Yamashita, S Yamada, M Kitamura, S Murakami
BACKGROUND AND OBJECTIVE: Single nucleotide polymorphisms (SNPs) of paraoxonase 1 (PON1) are known to be associated with the pathogenesis of osteoporosis and periodontitis. However, the effects of PON1 on the osteoblastic differentiation of periodontal ligament (PDL) cells are unclear. In this study, we examined the effects of PON1 on the osteoblastic differentiation of PDL cells, and analysed the role of PON1 SNPs on the pathogenesis of aggressive periodontitis (AgP) in the Japanese population...
October 24, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29049204/the-genetic-association-between-pon1-polymorphisms-and-osteonecrosis-of-femoral-head-a-case-control-study
#10
Jian-Mei Li, Yi Li, Lu Wang
The purpose of this study was to investigate the relationship between Paraoxonase-1 (PON1) gene rs662, rs854555 polymorphisms and osteonecrosis of the femoral head (ONFH) in Han population, northern China.Polymerase chain reaction-restriction fragment length polymorphism was used to determine genotypes of PON1 polymorphisms in 84 patients with ONFH and 96 healthy persons. χ test was used to compare distribution differences of genotype, allele, and haplotype between the case and control groups. The odds ratio (OR) and 95% confidence interval (CI) were calculated to reveal the effects of PON1 polymorphisms on risk of ONFH, and the results were adjusted using logistic regression analysis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29035403/-polymorphism-of-genes-encoding-proteins-of-dna-repair-vs-occupational-and-environmental-exposure-to-lead-arsenic-and-pesticides
#11
REVIEW
Karol Bukowski, Katarzyna Woźniak
Genetic polymorphism is associated with the occurrence of at least 2 different alleles in the locus with a frequency higher than 1% in the population. Among polymorphisms we can find single nucleotide polymorphism (SNP) and polymorphism of variable number of tandem repeats. The presence of certain polymorphisms in genes encoding DNA repair enzymes is associated with the speed and efficiency of DNA repair and can protect or expose humans to the effects provoked by xenobiotics. Chemicals, such as lead, arsenic pesticides are considered to exhibit strong toxicity...
October 12, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28954597/a-meta-analysis-on-the-relationship-of-the-pon-genes-and-alzheimer-disease
#12
Yi Nie, Danyang Luo, Min Yang, Yi Wang, Li Xiong, Li Gao, Yan Liu, Hua Liu
AIM: This study aimed to evaluate the association of the paraoxonase (PON) gene variants and Alzheimer disease (AD) using meta-analysis. METHODS: Relevant studies were identified by searching English and Chinese databases extensively. Allele and genotype frequencies for each included study were extracted. Newcastle-Ottawa Scale (NOS) was employed to assess the quality of included studies. The odds ratio (OR) with 95% confidence interval (95% CI) was calculated using a random-effects or fixed-effects model...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28889264/metals-and-paraoxonases
#13
Lucio G Costa, Toby B Cole, Jacqueline M Garrick, Judit Marsillach, Clement E Furlong
The paraoxonases (PONs) are a three-gene family which includes PON1, PON2, and PON3. PON1 and PON3 are synthesized primarily in the liver and a portion is secreted in the plasma, where they are associated with high-density lipoproteins (HDLs), while PON2 is an intracellular enzyme, expressed in most tissues and organs, including the brain. PON1 received its name from its ability to hydrolyze paraoxon, the active metabolite of the organophosphorus (OP) insecticide parathion, and also more efficiently hydrolyzes the active metabolites of several other OPs...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28875477/effects-of-pon1-gene-promoter-dna-methylation-and-genetic-variations-on-the-clinical-outcomes-of-dual-antiplatelet-therapy-for-patients%C3%A2-undergoing-percutaneous-coronary-intervention
#14
He-Ping Lei, Xi-Yong Yu, Hong Wu, Yan-Hong Kang, Wan-Ping Zhong, Li-Yun Cai, Meng-Zhen Zhang, Ji-Yan Chen, Li-Ping Mai, Qing-Shan Ding, Min Yang, Shi-Long Zhong
INTRODUCTION AND OBJECTIVE: The relationship between either paraoxonase 1 (PON1) gene promoter DNA methylation or genetic variations and bleeding or major adverse cardiac events after dual antiplatelet therapy has been incompletely characterized. We aimed to systematically investigate the role of genetic variations and DNA methylation of the PON1 CpG island promoter on the clinical outcomes of dual antiplatelet therapy for patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI)...
September 5, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28866115/association-between-promoter-polymorphism-108c-t-of-paraoxonase1-gene-and-it-s-paraoxonase-activity-in-patients-with-type2-diabetes-in-northern-iran
#15
Raheleh Shakeri, Safoura Khajeniazi, Abdoljalal Marjani
Type 2 diabetes mellitus (T2DM) is one of the diseases which depend on the obesity associated with insulin resistance. Various factors, such as a reduction in the activity of paraoxonase-1 enzyme (PON1), could affect T2DM. PON1 is a multifunctional enzyme with paraoxonase and arylesterase activities. The Activity of PON1 is influenced by various SNPs. The aim of presence study is to investigate the association between promoter polymorphism (-108C>T) of PON1 gene and its paraoxonase activity in patients suffering from Type 2 diabetes in Golestan Province, north of Iran...
November 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28862184/ocular-distribution-of-antioxidant-enzyme-paraoxonase-its-alteration-in-cataractous-lens-diabetic-retina
#16
Subramaniam Rajesh Bharathidevi, Kannadasan Anand Babu, Nishit Jain, Sivashanmugam Muthukumaran, Vetrivel Umashankar, J Biswas, Narayanasamy Angayarkanni
BACKGROUND & OBJECTIVES: The enzyme paraoxonase (PON), an antioxidant enzyme that has both arylesterase and thiolactonase activity, is well studied in cardiovascular diseases. Although a few studies have shown altered PON activity in ocular diseases such as age-related macular degeneration and diabetic retinopathy, but the tissue-wise expression of PON in its three gene forms has not been studied. This study was conducted to see the ocular distribution of PON for any altered expression in ocular pathologies such as in cataract and diabetes mellitus...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28861298/a-pilot-study-assessing-the-association-between-paraoxonase-1-gene-polymorphism-and-prostate-cancer
#17
Nihat Uluocak, Doğan Atılgan, Bekir Süha Parlaktaş, Fikret Erdemir, Ömer Ateş
OBJECTIVE: We aimed to show the relationship between paraoxonase 1 (PON1) gene polymorphism and the development of prostate cancer (PCa). MATERIAL AND METHODS: We investigated the association of single nuclotide polymorphisms of PON1 enzyme with the development of PCa risk. A total of 147 male patients were divided into PCa, and control groups. The control group was also divided into two subgroups according to serum prostate specific antigen (PSA) levels as non PCa-high PSA (>4 ng/mL) and non PCa-low PSA (≤4 ng/mL) groups...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28835968/pon1-l55m-and-q192r-gene-polymorphisms-and-cad-risks-in-patients-with-hyperlipidemia-clinical-study-of-possible-associations
#18
H Chen, S Ding, M Zhou, X Wu, X Liu, J Liu, Y Wu, D Liu
OBJECTIVE: A decreased plasma high density lipoprotein (HDL) cholesterol level is a strong risk factor for coronary artery disease (CAD). Antioxidant activity of HDL mainly lies in the activity of paraoxonase (PON). This study aimed to investigate the relationships between PON1 L55M and Q192R polymorphisms, and the risks of CAD in patients with hyperlipidemia. METHODS: From January 2014 to January 2016, 244 patients were divided into hyperlipidemia, hyperlipidemia + CAD, and control groups...
August 23, 2017: Herz
https://www.readbyqxmd.com/read/28827732/genetic-predisposition-to-lung-cancer-comprehensive-literature-integration-meta-analysis-and-multiple-evidence-assessment-of-candidate-gene-association-studies
#19
Junjun Wang, Qingyun Liu, Shuai Yuan, Weijia Xie, Yuan Liu, Ying Xiang, Na Wu, Long Wu, Xiangyu Ma, Tongjian Cai, Yao Zhang, Zhifu Sun, Yafei Li
More than 1000 candidate-gene association studies on genetic susceptibility to lung cancer have been published over the last two decades but with few consensuses for the likely culprits. We conducted a comprehensive review, meta-analysis and evidence strength evaluation of published candidate-gene association studies in lung cancer up to November 1, 2015. The epidemiological credibility of cumulative evidence was assessed using the Venice criteria. A total of 1018 publications with 2910 genetic variants in 754 different genes or chromosomal loci were eligible for inclusion...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821001/influence-on-serum-asymmetric-dimethylarginine-adma-concentrations-of-human-paraoxonase-1-polymorphism-q192r-and-exposure-to-polycyclic-aromatic-hydrocarbons-pahs-in-mexican-women-a-gene-environment-interaction
#20
Ángeles C Ochoa-Martínez, Tania Ruíz-Vera, Claudia I Almendarez-Reyna, Sandra T Orta-García, Iván N Pérez-Maldonado
It has been demonstrated that Cardiovascular Diseases (CVD) are a consequence of the combination of genetic and environmental factors and/or the interaction between them. Therefore, the aim of this study was to evaluate the impact of polycyclic aromatic hydrocarbon (PAHs) exposure and PON1 Q192R polymorphism (genetic susceptibility) on serum asymmetric dimethylarginine (ADMA) levels in Mexican women (n = 206). Urinary 1-hydroxypyrene concentrations (1-OHP; exposure biomarker for PAHs) were quantified using a high-performance liquid chromatography technique, PON1 Q192R polymorphism was genotyped using TaqMan probes and serum ADMA concentrations were evaluated using a commercially available ELISA kit...
November 2017: Chemosphere
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