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PON1 gene

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https://www.readbyqxmd.com/read/29118461/relationship-between-rs854560-pon1-gene-polymorphism-and-tobacco-smoking-with-coronary-artery-disease
#1
Joanna Iwanicka, Tomasz Iwanicki, Paweł Niemiec, Tomasz Nowak, Jolanta Krauze, Władysław Grzeszczak, Sylwia Górczyńska-Kosiorz, Anna Ochalska-Tyka, Iwona Żak
Paraoxonase-1 (PON1) is the antioxidant marker of high-density lipoproteins protecting against atherosclerosis and coronary artery disease (CAD) phenotype. The purpose of the present study was to determine whether the PON1 gene rs854560 polymorphism (163T>A) is associated with CAD in Polish population. rs854560 was genotyped in 494 subjects: 248 patients with premature CAD and 246 blood donors as a control. We found that the risk of CAD was significantly higher in TT homozygotes than in A allele carriers (OR = 1...
2017: Disease Markers
https://www.readbyqxmd.com/read/29063603/effects-of-paraoxonase-1-on-the-cytodifferentiation-and-mineralization-of-periodontal-ligament-cells
#2
R Masumoto, J Kitagaki, M Matsumoto, S Miyauchi, C Fujihara, M Yamashita, S Yamada, M Kitamura, S Murakami
BACKGROUND AND OBJECTIVE: Single nucleotide polymorphisms (SNPs) of paraoxonase 1 (PON1) are known to be associated with the pathogenesis of osteoporosis and periodontitis. However, the effects of PON1 on the osteoblastic differentiation of periodontal ligament (PDL) cells are unclear. In this study, we examined the effects of PON1 on the osteoblastic differentiation of PDL cells, and analysed the role of PON1 SNPs on the pathogenesis of aggressive periodontitis (AgP) in the Japanese population...
October 24, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29049204/the-genetic-association-between-pon1-polymorphisms-and-osteonecrosis-of-femoral-head-a-case-control-study
#3
Jian-Mei Li, Yi Li, Lu Wang
The purpose of this study was to investigate the relationship between Paraoxonase-1 (PON1) gene rs662, rs854555 polymorphisms and osteonecrosis of the femoral head (ONFH) in Han population, northern China.Polymerase chain reaction-restriction fragment length polymorphism was used to determine genotypes of PON1 polymorphisms in 84 patients with ONFH and 96 healthy persons. χ test was used to compare distribution differences of genotype, allele, and haplotype between the case and control groups. The odds ratio (OR) and 95% confidence interval (CI) were calculated to reveal the effects of PON1 polymorphisms on risk of ONFH, and the results were adjusted using logistic regression analysis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29035403/-polymorphism-of-genes-encoding-proteins-of-dna-repair-vs-occupational-and-environmental-exposure-to-lead-arsenic-and-pesticides
#4
REVIEW
Karol Bukowski, Katarzyna Woźniak
Genetic polymorphism is associated with the occurrence of at least 2 different alleles in the locus with a frequency higher than 1% in the population. Among polymorphisms we can find single nucleotide polymorphism (SNP) and polymorphism of variable number of tandem repeats. The presence of certain polymorphisms in genes encoding DNA repair enzymes is associated with the speed and efficiency of DNA repair and can protect or expose humans to the effects provoked by xenobiotics. Chemicals, such as lead, arsenic pesticides are considered to exhibit strong toxicity...
October 12, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28954597/a-meta-analysis-on-the-relationship-of-the-pon-genes-and-alzheimer-disease
#5
Yi Nie, Danyang Luo, Min Yang, Yi Wang, Li Xiong, Li Gao, Yan Liu, Hua Liu
AIM: This study aimed to evaluate the association of the paraoxonase (PON) gene variants and Alzheimer disease (AD) using meta-analysis. METHODS: Relevant studies were identified by searching English and Chinese databases extensively. Allele and genotype frequencies for each included study were extracted. Newcastle-Ottawa Scale (NOS) was employed to assess the quality of included studies. The odds ratio (OR) with 95% confidence interval (95% CI) was calculated using a random-effects or fixed-effects model...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28889264/metals-and-paraoxonases
#6
Lucio G Costa, Toby B Cole, Jacqueline M Garrick, Judit Marsillach, Clement E Furlong
The paraoxonases (PONs) are a three-gene family which includes PON1, PON2, and PON3. PON1 and PON3 are synthesized primarily in the liver and a portion is secreted in the plasma, where they are associated with high-density lipoproteins (HDLs), while PON2 is an intracellular enzyme, expressed in most tissues and organs, including the brain. PON1 received its name from its ability to hydrolyze paraoxon, the active metabolite of the organophosphorus (OP) insecticide parathion, and also more efficiently hydrolyzes the active metabolites of several other OPs...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28875477/effects-of-pon1-gene-promoter-dna-methylation-and-genetic-variations-on-the-clinical-outcomes-of-dual-antiplatelet-therapy-for-patients%C3%A2-undergoing-percutaneous-coronary-intervention
#7
He-Ping Lei, Xi-Yong Yu, Hong Wu, Yan-Hong Kang, Wan-Ping Zhong, Li-Yun Cai, Meng-Zhen Zhang, Ji-Yan Chen, Li-Ping Mai, Qing-Shan Ding, Min Yang, Shi-Long Zhong
INTRODUCTION AND OBJECTIVE: The relationship between either paraoxonase 1 (PON1) gene promoter DNA methylation or genetic variations and bleeding or major adverse cardiac events after dual antiplatelet therapy has been incompletely characterized. We aimed to systematically investigate the role of genetic variations and DNA methylation of the PON1 CpG island promoter on the clinical outcomes of dual antiplatelet therapy for patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI)...
September 5, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28866115/association-between-promoter-polymorphism-108c-t-of-paraoxonase1-gene-and-it-s-paraoxonase-activity-in-patients-with-type2-diabetes-in-northern-iran
#8
Raheleh Shakeri, Safoura Khajeniazi, Abdoljalal Marjani
Type 2 diabetes mellitus (T2DM) is one of the diseases which depend on the obesity associated with insulin resistance. Various factors, such as a reduction in the activity of paraoxonase-1 enzyme (PON1), could affect T2DM. PON1 is a multifunctional enzyme with paraoxonase and arylesterase activities. The Activity of PON1 is influenced by various SNPs. The aim of presence study is to investigate the association between promoter polymorphism (-108C>T) of PON1 gene and its paraoxonase activity in patients suffering from Type 2 diabetes in Golestan Province, north of Iran...
November 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28862184/ocular-distribution-of-antioxidant-enzyme-paraoxonase-its-alteration-in-cataractous-lens-diabetic-retina
#9
Subramaniam Rajesh Bharathidevi, Kannadasan Anand Babu, Nishit Jain, Sivashanmugam Muthukumaran, Vetrivel Umashankar, J Biswas, Narayanasamy Angayarkanni
BACKGROUND & OBJECTIVES: The enzyme paraoxonase (PON), an antioxidant enzyme that has both arylesterase and thiolactonase activity, is well studied in cardiovascular diseases. Although a few studies have shown altered PON activity in ocular diseases such as age-related macular degeneration and diabetic retinopathy, but the tissue-wise expression of PON in its three gene forms has not been studied. This study was conducted to see the ocular distribution of PON for any altered expression in ocular pathologies such as in cataract and diabetes mellitus...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28861298/a-pilot-study-assessing-the-association-between-paraoxonase-1-gene-polymorphism-and-prostate-cancer
#10
Nihat Uluocak, Doğan Atılgan, Bekir Süha Parlaktaş, Fikret Erdemir, Ömer Ateş
OBJECTIVE: We aimed to show the relationship between paraoxonase 1 (PON1) gene polymorphism and the development of prostate cancer (PCa). MATERIAL AND METHODS: We investigated the association of single nuclotide polymorphisms of PON1 enzyme with the development of PCa risk. A total of 147 male patients were divided into PCa, and control groups. The control group was also divided into two subgroups according to serum prostate specific antigen (PSA) levels as non PCa-high PSA (>4 ng/mL) and non PCa-low PSA (≤4 ng/mL) groups...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28835968/pon1-l55m-and-q192r-gene-polymorphisms-and-cad-risks-in-patients-with-hyperlipidemia-clinical-study-of-possible-associations
#11
H Chen, S Ding, M Zhou, X Wu, X Liu, J Liu, Y Wu, D Liu
OBJECTIVE: A decreased plasma high density lipoprotein (HDL) cholesterol level is a strong risk factor for coronary artery disease (CAD). Antioxidant activity of HDL mainly lies in the activity of paraoxonase (PON). This study aimed to investigate the relationships between PON1 L55M and Q192R polymorphisms, and the risks of CAD in patients with hyperlipidemia. METHODS: From January 2014 to January 2016, 244 patients were divided into hyperlipidemia, hyperlipidemia + CAD, and control groups...
August 23, 2017: Herz
https://www.readbyqxmd.com/read/28827732/genetic-predisposition-to-lung-cancer-comprehensive-literature-integration-meta-analysis-and-multiple-evidence-assessment-of-candidate-gene-association-studies
#12
Junjun Wang, Qingyun Liu, Shuai Yuan, Weijia Xie, Yuan Liu, Ying Xiang, Na Wu, Long Wu, Xiangyu Ma, Tongjian Cai, Yao Zhang, Zhifu Sun, Yafei Li
More than 1000 candidate-gene association studies on genetic susceptibility to lung cancer have been published over the last two decades but with few consensuses for the likely culprits. We conducted a comprehensive review, meta-analysis and evidence strength evaluation of published candidate-gene association studies in lung cancer up to November 1, 2015. The epidemiological credibility of cumulative evidence was assessed using the Venice criteria. A total of 1018 publications with 2910 genetic variants in 754 different genes or chromosomal loci were eligible for inclusion...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821001/influence-on-serum-asymmetric-dimethylarginine-adma-concentrations-of-human-paraoxonase-1-polymorphism-q192r-and-exposure-to-polycyclic-aromatic-hydrocarbons-pahs-in-mexican-women-a-gene-environment-interaction
#13
Ángeles C Ochoa-Martínez, Tania Ruíz-Vera, Claudia I Almendarez-Reyna, Sandra T Orta-García, Iván N Pérez-Maldonado
It has been demonstrated that Cardiovascular Diseases (CVD) are a consequence of the combination of genetic and environmental factors and/or the interaction between them. Therefore, the aim of this study was to evaluate the impact of polycyclic aromatic hydrocarbon (PAHs) exposure and PON1 Q192R polymorphism (genetic susceptibility) on serum asymmetric dimethylarginine (ADMA) levels in Mexican women (n = 206). Urinary 1-hydroxypyrene concentrations (1-OHP; exposure biomarker for PAHs) were quantified using a high-performance liquid chromatography technique, PON1 Q192R polymorphism was genotyped using TaqMan probes and serum ADMA concentrations were evaluated using a commercially available ELISA kit...
November 2017: Chemosphere
https://www.readbyqxmd.com/read/28792790/recent-developments-and-future-directions-for-the-use-of-pharmacogenomics-in-cardiovascular-disease-treatments
#14
REVIEW
Elliot Berinstein, Andrew Levy
Cardiovascular disease is still the leading cause of death worldwide. There are many environmental and genetic factors that play a role in the development of cardiovascular disease. The treatment of cardiovascular disease is beginning to move in the direction of personalized medicine by using biomarkers from the patient's genome to design more effective treatment plans. Pharmacogenomics have already uncovered many links between genetic variation and response of many different drugs. Areas covered: This article will focus on the main polymorphisms that impact the risk of adverse effects and response efficacy of statins, clopidogrel, aspirin, β-blockers, warfarin dalcetrapib and vitamin E...
September 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28779954/paraoxonase-1-pon1-and-stroke-the-dilemma-of-genetic-variation
#15
REVIEW
Amir Tajbakhsh, Mehdi Rezaee, Mahdi Rivandi, Faranak Forouzanfar, Fahimeh Afzaljavan, Alireza Pasdar
Ischaemic stroke, which is mostly caused by atherosclerosis, is one of the most widely causes of mortality and morbidity. One of the most important enzymatic activities of paraoxonase-1 (PON1) in association with high-density lipoprotein (HDL) is the prevention of low-density lipoprotein (LDL) oxidation, which gives it an anti-atherogenic activity. PON1 expression and activity is influenced by various factors; the most important of which is genetic polymorphism, mainly single nucleotide polymorphisms (SNPs)...
August 3, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28761062/t2diacod-a-gene-atlas-of-type-2-diabetes-mellitus-associated-complex-disorders
#16
Jyoti Rani, Inna Mittal, Atreyi Pramanik, Namita Singh, Namita Dube, Smriti Sharma, Bhanwar Lal Puniya, Muthukurussi Varieth Raghunandanan, Ahmed Mobeen, Srinivasan Ramachandran
We performed integrative analysis of genes associated with type 2 Diabetes Mellitus (T2DM) associated complications by automated text mining with manual curation and also gene expression analysis from Gene Expression Omnibus. They were analysed for pathogenic or protective role, trends, interaction with risk factors, Gene Ontology enrichment and tissue wise differential expression. The database T2DiACoD houses 650 genes, and 34 microRNAs associated with T2DM complications. Seven genes AGER, TNFRSF11B, CRK, PON1, ADIPOQ, CRP and NOS3 are associated with all 5 complications...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28752728/evaluation-of-on-clopidogrel-platelet-reactivity-overtime-syntax-score-genetic-polymorphisms-and-their-relationship-to-one-year-clinical-outcomes-in-stemi-patients-undergoing-pci
#17
Harsha V Erathi, Rajasekhar Durgaprasad, Vanajakshamma Velam, P V Sarma, Madhavi Rodda, C Kapil, Sreedhar N Kanavath
OBJECTIVES: To investigate the variability of On-clopidogrel platelet reactivity overtime, the association between HTPR, gene polymorphism and Syntax Score (SS) for risk prediction of MACE in patients with ST-Elevation Myocardial Infarction (STEMI) undergoing percutaneous coronary intervention (PCI). BACKGROUND: Platelet function testing may be used to optimize antiplatelet therapy in high risk patients, but identification of this subset of patients remains a challenge...
July 27, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28721150/phenotype-distribution-of-the-paraoxonase-gene-in-patients-with-cardiac-disease
#18
Hamit Yasar Ellidag, Ozgur Aydin, Esin Eren, Necat Yilmaz, Tugra Gencpinar, Selcuk Kucukseymen, Akar Yilmaz, Fatma Demet Arslan Ince
INTRODUCTION: Paraoxonase (PON1) is an enigmatic enzyme with multiple enzymatic properties including arylesterase and lactonase activities besides its ability to hydrolyze the toxic metabolite of parathion, paraoxon. The aim of this study was to determine the phenotype distribution of PON1 in patients with cardiac disease who were classified in coronary artery bypass grafting (CABG), heart valve disease (HVD), heart failure (HF) and ST elevation myocardial infarction (STEMI) groups and healthy subjects as a control group...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28670394/pfp-alleviates-nonalcoholic-steatohepatitis-fatty-liver-in-both-apo-e-mice-and-changliver-cell-s
#19
Dong Yan, Yuan-Yuan Wei, Xiu-Mei Li, Xiu-Chao Sun, Zhong Wang, Haji Akber Aisa
High-calorie food leads to nonalcoholic fatty liver disease (NAFLD) through the dysregulation of genes involved in lipid metabolism, but the precise mechanism is still unknown. Pomegranate flowers are used to treat diabetes mellitus in traditional Uighur medicine. Here we sought to investigate the effect and mechanism of pomegranate flower polyphenols (PFP) on NAFLD Apo E(-/-) mice induced by a high-fat diet (HFD) and whether PFP improves NAFLD through decreasing oxidative stress. PFP supplementation in mice significantly reduced the HFD-induced gains in body weight compared with the mice fed only with HFD...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28657841/association-between-dementia-and-vascular-disease-associated-polymorphisms-in-a-tunisian-population
#20
Hamdouni Haithem, Achour Ons, Naija Salma, Rejeb Jihène, Aounallah Mariam, Mhiri Mariem, Noureddine Mariem, Ben Rejeb Nabila, Omezzine Asma, Ben Amor Sana, Benammou Sofien, Bouslama Ali
Dementia is a multifactorial idiopathic pathology caused by clinical, environmental and genetic factors. Hence its etiology is still unknown. We aimed to evaluate the association between five genetic risk factors for vascular diseases and dementia individually and when gathered in haplotypes. We enrolled 200 dementia patients and 300 controls. All subjects were genotyped for vascular disease-associated polymorphisms in the genes coding for Apolipoprotein-E (ApoE), Angiotensin Converting Enzyme (ACE) and Paraoxonase-1 (PON1)...
June 28, 2017: International Journal of Neuroscience
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