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antioxidant intake

Emerson H Yoshimura, Nadine W Santos, Erica Machado, Bruna C Agustinho, Lucelia M Pereira, Sílvia C de Aguiar, Anacharis B Sá-Nakanishi, Cecília E Mareze-da-Costa, Lucia M Zeoula
The increasing incidence of diabetes mellitus is becoming a serious threat to human health in various parts of the world. Studies with dairy products have shown a potential beneficial effect against diabetes. This experiment evaluated the supplementation of milk naturally enriched with polyunsaturated fatty acids (PUFA) and polyphenols in rats with streptozotocin-induced diabetes. Forty male 28-day-old Wistar rats were distributed in four experimental treatments of diabetic animals (streptozotocin induction) and a normal group (non-induced)...
2018: PloS One
Armando Platania, Dora Castiglione, Dario Sinatra, Maurizio D' Urso, Marina Marranzano
The aim of the present study was to investigate the total water intake (TWI) from drinks and foods and to evaluate the correlation between the different types of drinks on energy and antioxidant intake. The cohort comprised 1602 individuals from the city of Catania in Southern Italy. A food frequency questionnaire was administered to assess dietary and water intake. The mean total water intake was 2.7 L; more than about two thirds of the sample met the European recommendations for water intake. Water and espresso coffee were the most consumed drinks...
April 9, 2018: Antioxidants (Basel, Switzerland)
Kazim Sahin, Engin Yenice, Mehmet Tuzcu, Cemal Orhan, Cengizhan Mizrak, Ibrahim H Ozercan, Nurhan Sahin, Bahiddin Yilmaz, Birdal Bilir, Bulent Ozpolat, Omer Kucuk
Background: Dietary intake of lycopene has been associated with a reduced risk of ovarian cancer, suggesting its chemopreventive potential against ovarian carcinogenesis. Lycopene's molecular mechanisms of action in ovarian cancer have not been fully understood. Therefore, in the present study, we investigated the effects of lycopene on the ovarian cancer formation using the laying hen model, a biologically relevant animal model of spontaneous ovarian carcinogenesis due to high incidence rates similar to humans...
March 2018: Journal of Cancer Prevention
Ji Young Hong, Chang Youl Lee, Myung Goo Lee, Young Sam Kim
OBJECTIVE: Cigarette smoke-induced oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Dietary antioxidants are thought to prevent smoke-induced oxidative damage. The aim of this study was to investigate associations between lung function and the consumption of antioxidant vitamins in Korean adults. METHODS: In total, 21 148 participants from the Korean National Health and Nutrition Examination Survey (2007-2014) were divided into four groups based on smoking history and gender...
April 7, 2018: BMJ Open
Muhammad Jihad Sandikapura, Shaik Nyamathulla, Mohamed Ibrahim Noordin
The study was aimed to perform aqueous extraction of two plants using different extraction methods, and evaluate their antioxidant and antidiabetic potential. Plant materials were extracted by maceration, soxhlet, sonication and fresh juice methods to produce aqueous extracts. In vitro antioxidant DPPH (1,1-diphenyl-2- picrylhydrazyl) and FRAP (Ferric reducing antioxidant power), antidiabetic α-amylase and α-glucosidase enzyme inhibitory assays were carried out on the extracts. Extracts of Syzygium polyanthum demonstrated better free radical scavenging and antidiabetic activity than Momordica charantia...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Nasrin Sharifi, Reza Tabrizi, Mahmood Moosazadeh, Naghmeh Mirhosseini, Kamran B Lankarani, Maryam Akbari, Maryam Chamani, Fariba Kolahdooz, Zatollah Asemi
BACKGROUND AND OBJECTIVE: Oxidative stress and inflammation are key parameters in developing metabolic disorders. Hence, antioxidant intake might be an appropriate approach. Several studies have evaluated the effect of coenzyme Q10 (CoQ10) supplementation on lipid profile among patients with metabolic diseases, though findings are controversial. The aim of this systematic review and meta-analysis was to determine the effects of CoQ10 supplementation on lipid profile in patients with metabolic disorders...
April 5, 2018: Current Pharmaceutical Design
Anca Oana Docea, Eliza Gofita, Marina Goumenou, Daniela Calina, Otilia Rogoveanu, Marius Varut, Cristian Olaru, Efthalia Kerasioti, Polyxeni Fountoucidou, Ioannis Taitzoglou, Ovidiu Zlatian, Valerii N Rakitskii, Antonio F Hernandez, Dimitrios Kouretas, Aristidis Tsatsakis
This study assessed the potential adverse health effects of long-term low-dose exposure to chemical mixtures simulating complex real-life human exposures. Four groups of Sprague Dawley rats were administered mixtures containing carbaryl, dimethoate, glyphosate, methomyl, methyl parathion, triadimefon, aspartame, sodium benzoate, calcium disodium ethylene diamine tetra-acetate, ethylparaben, butylparaben, bisphenol A, and acacia gum at doses of 0, 0.25, 1 or 5 times the respective Toxicological Reference Values (TRV): acceptable daily intake (ADI) or tolerable daily intake (TDI) in a 24 weeks toxicity study...
April 2, 2018: Food and Chemical Toxicology
Laury Sellem, Bernard Srour, Françoise Guéraud, Fabrice Pierre, Emmanuelle Kesse-Guyot, Thibault Fiolet, Céline Lavalette, Manon Egnell, Paule Latino-Martel, Philippine Fassier, Serge Hercberg, Pilar Galan, Mélanie Deschasaux, Mathilde Touvier
PURPOSE: Lipid intakes such as saturated (SFA), monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids have been widely studied regarding cardiovascular health, but their relevance to cancer is unclear. Inconsistent epidemiological results may be explained by varied mechanisms involving PUFAs and redox balance, inflammatory status and cell signalling, along with interactions with other dietary components such as antioxidants, dietary fibre and more generally fruits and vegetable intakes...
April 3, 2018: European Journal of Nutrition
Rachna Khosla Sardana, Navnidhi Chhikara, Beenu Tanwar, Anil Panghal
Cancer is the abnormal growth of cells that tend to proliferate in an uncontrolled way. About 32.6 million people in the world are affected by different types of cancer; 456 000 have esophageal cancer, which is the eighth most common cancer and the sixth most common cause of cancer-related deaths with a toll of 400 000 in 2012. About 80% of cases were reported from the less developed regions of the world. An incidence ratio of 2.4 : 1 for men and women reveals the gender disparity. Esophageal cancer is mainly of two types, namely, squamous cell carcinoma and adenocarcinoma...
April 4, 2018: Food & Function
David Morales-Alamo, Borja Guerra, Alfredo Santana, Marcos Martin-Rincon, Miriam Gelabert-Rebato, Cecilia Dorado, José A L Calbet
Compared to normoxia, during sprint exercise in severe acute hypoxia the glycolytic rate is increased leading to greater lactate accumulation, acidification, and oxidative stress. To determine the role played by pyruvate dehydrogenase (PDH) activation and reactive nitrogen and oxygen species (RNOS) in muscle lactate accumulation, nine volunteers performed a single 30-s sprint (Wingate test) on four occasions: two after the ingestion of placebo and another two following the intake of antioxidants, while breathing either hypoxic gas (PI O2 = 75 mmHg) or room air (PI O2 = 143 mmHg)...
2018: Frontiers in Physiology
Abdulkerim Eroglu, Kerry J Schulze, James Yager, Robert N Cole, Parul Christian, Bareng A S Nonyane, Sun Eun Lee, Lee Shu Fune Wu, Subarna Khatry, John Groopman, Keith P West
Carotenoids are naturally occurring pigments that function as vitamin A precursors, antioxidants, anti-inflammatory agents or biomarkers of recent vegetable and fruit intake, and are thus important for population health and nutritional assessment. An assay approach that measures proteins could be more technologically feasible than chromatography, thus enabling more frequent carotenoid status assessment. We explored associations between proteomic biomarkers and concentrations of 6 common dietary carotenoids (α-carotene, β-carotene, lutein/zeaxanthin, β-cryptoxanthin, and lycopene) in plasma from 500 6-8 year old Nepalese children...
March 29, 2018: Archives of Biochemistry and Biophysics
Wen-Ting Cao, Fang-Fang Zeng, Bao-Lin Li, Jie-Sheng Lin, Ya-Yong Liang, Yu-Ming Chen
BACKGROUND: Mechanism studies have suggested that carotenoids may benefit bone health due to their antioxidant properties, but epidemiological data on their effects on risk of hip fracture are sparse. PURPOSE: To explore the relationships between dietary total and specific carotenoids and the risk of hip fracture in a middle-aged and elderly Chinese population. DESIGN: A case-control study of 1070 patients with hip fractures (diagnosed within 2 weeks) aged 55-80 years and 1070 age- (within 3 years) and gender-matched controls was conducted in Guangdong, China between 2009 and 2015...
March 29, 2018: Bone
Thalita Marcílio Cândido, Camila Areias De Oliveira, Maíra Bueno Ariede, Maria Valéria Robles Velasco, Catarina Rosado, André Rolim Baby
Topical application of dermocosmetics containing antioxidant and/or the intake of antioxidants through diet or supplementation are remarkable tools in an attempt to slow down some of the harmful effects of free radicals. Rutin is a strong antioxidant compound used in food and pharmaceutical industries. It was established that rutin presents a low skin permeation rate, a property that could be considered an inconvenience to the satisfactory action for a dermocosmetic formulation to perform its antioxidant activity onto the skin...
March 29, 2018: AAPS PharmSciTech
Xia Wang, Xiaoyuan Du, Yang Zhou, Su Wang, Feng Su, Shicui Zhang
One of the most studied and widely accepted conjectures of aging process is the oxidative stress theory. Previous studies have shown that salidroside can protect D-galactose-induced mouse model against aging and a formulation of Rhodiola rosea extracts (SHR-5) containing salidroside increases lifespan of fruit fly. However, direct evidence linking salidroside itself with the observed anti-aging effect in vivo and relevant molecular mechanisms are poorly defined. In this study, we first demonstrated that salidroside exhibited a time-dependent effect, and late-onset long-term salidroside dietary intake extended the lifespan in the annual fish Nothobranchius guentheri ...
March 13, 2018: Oncotarget
Saman Lashkari, Mahmood Habibian, Søren Krogh Jensen
With the increase in the global herd, the use of metabolic modifiers has become an important area for many researchers looking for a supraphysiological diet to improve production parameters. For improving the performance of high yielding cows, the optimal balance of all nutrients including microminerals is important. Chromium (Cr) is one of the important micronutrients which plays an important role in metabolism of ruminants. Experimental studies have found that Cr could change performance, immune responses, glucose and fatty acid metabolism, and antioxidant status in dairy cows...
March 28, 2018: Biological Trace Element Research
Chunxue Zhou, Suraj B Teegala, Bilal A Khan, Christina Gonzalez, Vanessa H Routh
Hypoglycemia is a profound threat to the brain since glucose is its primary fuel. As a result, glucose sensors are widely located in the central nervous system and periphery. In this perspective we will focus on the role of hypothalamic glucose-inhibited (GI) neurons in sensing and correcting hypoglycemia. In particular, we will discuss GI neurons in the ventromedial hypothalamus (VMH) which express neuronal nitric oxide synthase (nNOS) and in the perifornical hypothalamus (PFH) which express orexin. The ability of VMH nNOS-GI neurons to depolarize in low glucose closely parallels the hormonal response to hypoglycemia which stimulates gluconeogenesis...
2018: Frontiers in Physiology
Angela Hernández-Ruiz, Belén García-Villanova, Eduardo Guerra-Hernández, Pilar Amiano, María-José Sánchez, Miren Dorronsoro, Esther Molina-Montes
BACKGROUND: The Mediterranean Diet (MD) is a dietary pattern that features a high quotient of antioxidant-rich foods. Differences in the level of dietary antioxidants intake reflected by different MD indexes has received little research attention. OBJECTIVE: The purpose of this study was to compare the dietary antioxidant profile of 21 a priori defined indexes of adherence to the MD. DESIGN: A cross-sectional study. PARTICIPANTS/SETTING: A total of 14,756 participants belonging to two Spanish European Prospective Investigation into Cancer and Nutrition cohorts, aged 32 to 69 years, recruited between 1992 and 1996, were included...
March 24, 2018: Journal of the Academy of Nutrition and Dietetics
Andrew B Falowo, Felicitas E Mukumbo, Emrobowansan M Idamokoro, José M Lorenzo, Anthony J Afolayan, Voster Muchenje
Research on the use of various parts of the Moringa oleifera Lam. plant (M. oleifera) as a nutritional and neutraceutical resource for human and animal diets has increased in recent years, emanating from the widespread use of the plant in traditional cuisines and medicinal remedies in several regions of the world. Analytical studies have identified M. oleifera as an important source of essential nutrients; rich in protein, essential amino acids, minerals, and vitamins, with a relatively low amount of antinutrients...
April 2018: Food Research International
Mingcai Liang, Zhengxuan Wang, Hui Li, Liang Cai, Jianghao Pan, Hongjuan He, Qiong Wu, Yinzhao Tang, Jiapei Ma, Lin Yang
Arginine is a conditionally essential amino acid. To elucidate the influence of l-arginine on the activation of endogenous antioxidant defence, male Wistar rats were orally administered daily with l-arginine at different levels of 25, 50, 100 mg/100 g body weight. After 7 and 14 days feeding, the antioxidative capacities and glutathione (GSH) contents in the plasma and in the liver were uniformly enhanced with the increasing consumption of l-arginine, whereas the oxidative stress was effectively suppressed by l-arginine treatment...
March 22, 2018: Food and Chemical Toxicology
Huiying Cong, Wenxia Zhong, Yiying Wang, Shoichiro Ikuyama, Bin Fan, Jianqiu Gu
Beige adipocytes in white adipose tissue (WAT) have received considerable recognition because of their potential protective effect against obesity. Pycnogenol (PYC), extracted from French maritime pine bark, has anti-inflammatory and antioxidant properties and can improve lipid profiles. However, the effect of PYC on obesity has never been explored. In this study, we investigated the effects of PYC on obesity and WAT browning in apolipoprotein E- (ApoE-) deficient mice. The results showed that PYC treatment clearly reversed body weight and the mass of eWAT gain resulting from a high-cholesterol and high-fat diet (HCD), but no difference in food intake...
2018: Journal of Diabetes Research
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