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antioxidant intake

Sevtap Han, Nur Banu Bal, Gökhan Sadi, Suzan E Usanmaz, M Orhan Uludag, Emine Demirel-Yilmaz
The purpose of this study was to determine the effects of resveratrol and regular aerobic exercise on vascular functions and biomarkers related to vessel responsiveness in an age and gender-dependent manner. The study used young (3 months) and old (12 months) male and female Wistar albino rats. Resveratrol was given in the drinking water (0.05 mg/ml; approximately 7.5 mg/kg) for 6 weeks. In the exercise group, all rats performed treadmill running at 20 m/min on a 0° incline, 40 min/day, 3 times a week, for 6 weeks...
June 13, 2018: Experimental Gerontology
Nadine Schmidt, Tim Luhmann, Liane Hüther, Ulrich Meyer, Stefanie A Barth, Lutz Geue, Christian Menge, Jana Frahm, Sven Dänicke
Vitamin E (vit E), an essential antioxidant for maintaining the stability of biological membranes and the function of the immune system, is considered to support adaptive immune responses and performance in cattle. The principal virulence factor of Shiga toxin (Stx)-producing Escherichia coli (STEC), the eponymous Stx, modulates cellular immune responses in cattle, the primary STEC reservoir. Active and passive immunization of calves with Shiga toxoids (rStxMUT ) was recently shown to reduce the STEC shedding...
June 15, 2018: Journal of Animal Physiology and Animal Nutrition
Seyed Mohammad Nabavi, Seyed Fazel Nabavi, Antoni Sureda, Janbo Xiao, Ahmad Reza Dehpour, Samira Shirooie, Ana Sanches Silva, Alessandra Baldi, Haroon Khan, Maria Daglia
N-acetyl-5-methoxy-tryptamine (melatonin) is a natural substance produced both by plants, as a secondary metabolite, and animals, by the pineal gland and other tissues. In humans, melatonin participates in numerous functions including the regulation of mood, sleep, reproduction, promotion of immunomodulation, antioxidant defense and as an anti-inflammatory agent. The anti-inflammatory activity of melatonin could yield beneficial effects on intake, particularly against the chronic inflammation which underlies many chronic diseases...
June 14, 2018: Critical Reviews in Food Science and Nutrition
Masuko Kobori, Yumiko Takahashi, Hiroaki Takeda, Masatomo Takahashi, Yoshihiro Izumi, Yukari Akimoto, Mutsumi Sakurai, Hideaki Oike, Toshiyuki Nakagawa, Masanori Itoh, Takeshi Bamba, Toshiyuki Kimura
White adipose tissue (eWAT) plays a crucial role in preventing metabolic syndrome. We aimed to investigate WAT distribution and gene expression and lipidomic profiles in epididymal WAT (eWAT) in diet-induced obese mice, reflecting a Western-style diet of humans to elucidate the bioactive properties of the dietary antioxidant curcumin in preventing lifestyle-related diseases. For 16 weeks, we fed C57BL/6J mice with a control diet, a high-fat, high-sucrose and high-cholesterol Western diet or Western diet supplemented with 0...
June 13, 2018: Scientific Reports
Renata Kuras, Edyta Reszka, Edyta Wieczorek, Ewa Jablonska, Jolanta Gromadzinska, Beata Malachowska, Lucyna Kozlowska, Magdalena Stanislawska, Beata Janasik, Wojciech Wasowicz
The present observation based research was designed to evaluate the influence of occupational human exposure to metallic mercury (Hg°) vapor on the biomarkers of selenium status involved in the antioxidant defense system. For this purpose we determined Hg and selenium (Se) concentrations in body fluids, the markers of antioxidant effect measured as an activity of Se-dependent enzymes (red blood cell and plasma glutathione peroxidase: GPx1-RBC and GPx3-P), concentration of selenoprotein P in the plasma (SeP-P) and total antioxidant activity in the plasma (TAA-P) in 131 male workers from a chloralkali plant exposed to Hg° and 67 non-exposed males (control group)...
September 2018: Journal of Trace Elements in Medicine and Biology
Wei-Ting Lee, Yu-Tang Tung, Chun-Ching Wu, Pang-Shuo Tu, Gow-Chin Yen
Ulcerative colitis (UC), one type of chronic inflammatory bowel disease (IBD), is a chronic and recurrent disorder of the gastrointestinal (GI) tract. As camellia oil (CO) is traditionally used to treat GI disorders, this study investigated the role of CO on acetic acid-induced colitis in the rat. The composition of the gut microbial community is related to many diseases, thus, this study also investigated the effects of CO on the composition of the gut microbiota. The rats were fed a dose of 2 mL/kg body weight CO, olive oil (OO), or soybean oil (SO) once a day for 20 days, and the gut microbiota was analyzed using 16S rRNA gene sequencing...
June 13, 2018: Journal of Agricultural and Food Chemistry
H C Müller, C L van Bibber-Krueger, J S Drouillard
Liver abscesses (LA) in cattle negatively affect feedlot performance by decreasing ADG, feed intake, and G:F ratio. Abscessed livers are condemned and abdominal adhesions associated with LA can result in extensive carcass trimming during harvest, further compounding adverse economic impact. Given regulatory changes pertaining to the use of in-feed antibiotics in cattle production, there is growing interest in alternatives to antibiotics for LA control. The objective of this study was to evaluate the use of antioxidants, crystalline ascorbate and alpha tocopherol acetate, for mitigation of LA in feedlot cattle...
June 9, 2018: Journal of Animal Science
Yi Jinn Lillian Chen, Pei-Chi Chou, Chang Lu Hsu, Jeng-Fung Hung, Yang-Chang Wu, Jaung-Geng Lin
Fermented lemon juice displays a variety of important biological activities, including anti-inflammatory and antioxidant capabilities. The aim of the present study is to investigate hepatic-protective effects of no-sugar-added fermented lemon juice (FLJ) for liver inflammation caused by carbon tetrachloride (CCl4 ) in rats. Rats are divided into six groups: H2 O, CCl4 + H2 O, CCl4 + silymarin, and CCl4 plus three different FLJ doses by oral administration, respectively. The results show that the contents of plasma ALT and AST, hepatic lipid peroxidation, splenomegaly, and liver water are reduced significantly in rats under FLJ treatment, and pathological examination of liver fibrosis is improved...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
P Merino, J A Santos-López, C J Mateos, I Meseguer, A Garcimartín, S Bastida, F J Sánchez-Muniz, J Benedí, M J González-Muñoz
Aluminum consumption has been associated with various neurodegenerative diseases. Previous studies suggest that regular beer intake reverses the pro-oxidant and inflammatory statuses induced by aluminum nitrate intoxication. This paper aims to evaluate the in vitro antioxidant capacity and acetylcholinesterase inhibitory activity of non-alcoholic beer (NABeer), silicon or hops, as well as their effect on animal behavior (e.g. curiosity, immobilization, rearing, grooming, swimming) and brain antioxidant enzyme (activity and gene expression) and anti-inflammatory status in aluminum nitrate intoxicated rats...
June 7, 2018: Food and Chemical Toxicology
Manfred Eggersdorfer, Adrian Wyss
Carotenoids are naturally occurring pigments found in most fruits and vegetables, plants, algae, and photosynthetic bacteria. Humans cannot synthesize carotenoids and must ingest them in food or via supplementation. Carotenoids have a range of functions in human health. They primarily exert antioxidant effects, but individual carotenoids may also act through other mechanisms; for example, β-carotene has a pro-vitamin A function, while lutein/zeaxanthin constitute macular pigment in the eye. The benefit of lutein in reducing progression of age-related macular eye disease and cataracts is strengthening; an intake recommendation would help to generate awareness in the general population to have an adequate intake of lutein rich foods...
June 6, 2018: Archives of Biochemistry and Biophysics
César Carneiro Linhares Fernandes, Paula Rodriguez-Villamil, Fábio Roger Vasconcelos, Celso Shiniti Nagano, Rafael Rossetto, Arlindo de Alencar Araripe Noronha Moura, Davide Rondina
This study was conducted to evaluate the effects of different feeding levels on the proteome of oviduct and uterus tissues of hormonally stimulated goats during the periovulatory period. Forty goats were separated into four different diet groups: Diet 1.0 M (n = 11), Diet 1.3 M (n = 10), Diet 1.6 M (n = 9), Diet 1.9 M (n = 10), fed with 1.0, 1.3, 1.6 and 1.9 times live weight maintenance, respectively. After four weeks of treatment, six hormonally stimulated females per treatment group were randomly selected for collection of uterine and the oviduct tissue samples...
June 8, 2018: Reproduction in Domestic Animals, Zuchthygiene
Annette Bernhard, Josef D Rasinger, Helene Wisløff, Øyvor Kolbjørnsen, Lene Secher Myrmel, Marc H G Berntssen, Anne-Katrine Lundebye, Robin Ørnsrud, Lise Madsen
The use of the synthetic antioxidant ethoxyquin (6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline; EQ) in animal feed results in the presence of EQ residues and metabolites, including the EQ dimer (1,8'-Bi(6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline); EQDM) in animal food products. To investigate the toxicity and dose-response of dietary exposure to EQDM, male BALB/c mice were exposed to one of six dietary doses of EQDM, ranging from 0.015 to 518 mg/kg body weight/day for 90 days. Doses above 10 mg/kg body weight/day affected whole body lipid metabolism resulting in increased liver weights and decreased adipose tissue mass...
June 5, 2018: Food and Chemical Toxicology
Irina Odinokova, Yulia Baburina, Alexey Kruglov, Irina Fadeeva, Alena Zvyagina, Linda Sotnikova, Vladimir Akatov, Olga Krestinina
Excessive generation of reactive oxygen species (ROS) in mitochondria and the opening of the nonselective mitochondrial permeability transition pore are important factors that promote cardiac pathologies and dysfunction. The hormone melatonin (MEL) is known to improve the functional state of mitochondria via an antioxidant effect. Here, the effect of MEL administration on heart mitochondria from aged rats with acute cardiac failure caused by isoprenaline hydrochloride (ISO) was studied. A histological analysis revealed that chronic intake of MEL diminished the age-dependent changes in the structure of muscle fibers of the left ventricle, muscle fiber swelling, and injury zones characteristic of acute cardiac failure caused by ISO...
May 23, 2018: International Journal of Molecular Sciences
Dongdong Wang, Cigdem Özen, Ibrahim M Abu-Reidah, Sridevi Chigurupati, Jayanta Kumar Patra, Jarosław O Horbanczuk, Artur Jóźwik, Nikolay T Tzvetkov, Pavel Uhrin, Atanas G Atanasov
Pomegranate ( Punica granatum L.), one of the oldest known edible fruits, is nowadays broadly consumed throughout the world. Its fruits and seeds as well as other anatomical compartments (e.g., flowers and leaves) are rich in numerous bioactive compounds and therefore, the scientific interest in this plant has been constantly growing in recent years. It has been shown that pomegranate and its extracts exhibit potent antioxidative, antimicrobial, and anticarcinogenic properties. The present review summarizes some recent studies on pomegranate, highlighting mainly its vasculoprotective role attributed to the presence of hydrolyzable tannins ellagitannins and ellagic acid, as well as other compounds (e...
2018: Frontiers in Pharmacology
Ana Valea, Carmen Emanuela Georgescu
Selenium (Se) has a multilevel, complex and dynamic effect on the human body as a major component of selenocysteine, incorporated into selenoproteins, which include the selenocysteine-containing enzymes iodothyronine deiodinases. At the thyroid level, these proteins play an essential role in antioxidant protection and hormone metabolism. This is a narrative review based on PubMed/Medline database research regarding thyroid physiology and conditions with Se and Se-protein interferences. In humans, Se-dependent enzyme functions are best expressed through optimal Se intake, although there is gap in our knowledge concerning the precise mechanisms underlying the interrelation...
June 5, 2018: Hormones: International Journal of Endocrinology and Metabolism
Daniela Gentile, Matteo Fornai, Carolina Pellegrini, Rocchina Colucci, Corrado Blandizzi, Luca Antonioli
Obesity represents one of major health problems strongly linked to other co-morbidities, such as type 2 diabetes, CVD, gastrointestinal disorders and cognitive impairment. In this context, nutritional stress, such as an excess of fat intake, promotes a systemic oxidative stress, characterised by hyperproduction of reactive oxygen species, leading to cellular alterations that include impaired energy metabolism, altered cell signalling and cell cycle control, impaired cell transport mechanisms and overall dysfunctional biological activity...
June 6, 2018: Nutrition Research Reviews
Mari C López-Pérez, Fabián Pérez-Labrada, Lino J Ramírez-Pérez, Antonio Juárez-Maldonado, América B Morales-Díaz, Susana González-Morales, Luis R García-Dávila, Jesús García-Mata, Adalberto Benavides-Mendoza
Silicon is an essential nutrient for humans, additionally is beneficial for terrestrial plants. In plants Si enhances tolerance to different types of stress; in humans, it improves the metabolism and increases the strength of skeletal and connective tissues as well as of the immune system. Most of the Si intake of humans come from edible plants creating a double benefit: first, because the absorption of Si increases the antioxidants and other phytochemicals in plants, thereby increasing its functional value, and second because the higher concentration of Si in plants increases intake in human consumers...
2018: Frontiers in Plant Science
Zukiswa Jiki, Sandrine Lecour, Frederic Nduhirabandi
The role of the diet as well as the impact of the dietary habits on human health and disease is well established. Apart from its sleep regulatory effect, the indoleamine melatonin is a well-established antioxidant molecule with multiple health benefits. Convincing evidence supports the presence of melatonin in plants and foods with the intake of such foods affecting circulating melatonin levels in humans. While numerous actions of both endogenous melatonin and melatonin supplementation are well described, little is known about the influence of the dietary melatonin intake on human health...
2018: Frontiers in Physiology
Weijiang Zheng, Xu Ji, Qing Zhang, Wenchao Du, Quanwei Wei, Wen Yao
The objective of the current experiment was to evaluate whether hydrogen-rich water (HRW) or lactulose (LAC) could protect against the adverse effects of Fusarium mycotoxins-contaminated diet on the growth performance and antioxidant status in weaning piglets. A total of 24 individually housed female piglets were randomly assigned to receive four treatments for 25 days (six pigs/treatment): uncontaminated basal diet (negative control), mycotoxin-contaminated (MC) diet, MC diet + HRW (MC + HRW) and MC diet + LAC (MC + LAC)...
June 4, 2018: Toxins
Angélique M E Spoelstra-de Man, Paul W G Elbers, Heleen M Oudemans-Van Straaten
PURPOSE OF REVIEW: Hypovitaminosis C and vitamin C deficiency are very common in critically ill patients due to increased needs and decreased intake. Because vitamin C has pleiotropic functions, deficiency can aggravate the severity of illness and hamper recovery. RECENT FINDINGS: Vitamin C is a key circulating antioxidant with anti-inflammatory and immune-supporting effects, and a cofactor for important mono and dioxygenase enzymes. An increasing number of preclinical studies in trauma, ischemia/reperfusion, and sepsis models show that vitamin C administered at pharmacological doses attenuates oxidative stress and inflammation, and restores endothelial and organ function...
June 1, 2018: Current Opinion in Critical Care
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