pirferidon

Idiopathic pulmonary fibrosis is a chronic and progressive disease with a significant mortality rate. Pirfenidone is one of two oral antifibrotic therapies approved to treat idiopathic pulmonary fibrosis (IPF). Pirfenidone helps decrease disease progression in patients with IPF and reduces vital capacity. This has led to widespread use of this medication in recent years. In this case report, we present a 60-year-old male who started treatment with pirfenidone for IPF and had severe skin reactions after initiation of therapy...

Hippo pathway transcriptional coactivators TAZ and YAP and the TGF-β1 (TGFβ) effector Smad3 regulate a common set of genes, can physically interact, and exhibit multilevel cross-talk regulating cell fate-determining and fibrogenic pathways. However, a key aspect of this cross-talk, TGFβ-mediated regulation of TAZ or YAP expression, remains uncharacterized. Here, we show that TGFβ induces robust TAZ but not YAP protein expression in both mesenchymal and epithelial cells. TAZ levels, and to a lesser extent YAP levels, also increased during experimental kidney fibrosis...

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Angiotensin II plays a pivotal role in the progression of renal diseases, including obstructive nephropathy. Increasing levels of angiotensin II in obstructive nephropathy upregulate the expression of several factors: transforming growth factor-beta1 (TGF-beta1), tumor necrosis factor-alpha (TNF-alpha), platelet-derived growth factor (PDGF), insulin-like growth factor (IGF-1), osteopontin, vascular cell adhesion molecule-1 (VCAM-1), nuclear factor-kappaB (NF-kappaB), monocyte chemoattractant peptide-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and CD14 among others...