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Ischemia-reperfusion injury

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https://www.readbyqxmd.com/read/29656335/role-of-microglia-under-cardiac-and-cerebral-ischemia-reperfusion-i-r-injury
#1
REVIEW
Poomarin Surinkaew, Passakorn Sawaddiruk, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C Chattipakorn
Both cerebral and cardiac ischemia causes loss of cerebral blood flow, which may lead to neuronal cell damage, neurocognitive impairment, learning and memory difficulties, neurological deficits, and brain death. Although reperfusion is required immediately to restore the blood supply to the brain, it could lead to several detrimental effects on the brain. Several studies demonstrate that microglia activity increases following cerebral and cardiac ischemic/reperfusion (I/R) injury. However, the effects of microglial activation in the brain following I/R remains unclear...
April 14, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29651748/improved-reperfusion-and-vasculoprotection-by-the-poly-adp-ribose-polymerase-inhibitor-pj34-after-stroke-and-thrombolysis-in-mice
#2
Mohamad El Amki, Dominique Lerouet, Marie Garraud, Fei Teng, Virginie Beray-Berthat, Bérard Coqueran, Benoît Barsacq, Charlotte Abbou, Bruno Palmier, Catherine Marchand-Leroux, Isabelle Margaill
Benefits from thrombolysis with recombinant tissue plasminogen activator (rt-PA) after ischemic stroke remain limited due to a narrow therapeutic window, low reperfusion rates, and increased risk of hemorrhagic transformations (HT). Experimental data showed that rt-PA enhances the post-ischemic activation of poly(ADP-ribose)polymerase (PARP) which in turn contributes to blood-brain barrier injury. The aim of the present study was to evaluate whether PJ34, a potent PARP inhibitor, improves poor reperfusion induced by delayed rt-PA administration, exerts vasculoprotective effects, and finally increases the therapeutic window of rt-PA...
April 12, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29651108/3d-artificial-round-section-micro-vessels-to-investigate-endothelial-cells-under-physiological-flow-conditions
#3
Riccardo Sfriso, Shengye Zhang, Colette Andrea Bichsel, Oliver Steck, Alain Despont, Olivier Thierry Guenat, Robert Rieben
In the context of xenotransplantation, in ischemia/reperfusion injury as well as in cardiovascular research, the study of the fascinating interplay between endothelial cells (EC) and the plasma cascade systems often requires in vitro models. Blood vessels are hardly reproducible with standard flat-bed culture systems and flow-plate assays are limited in their low surface-to-volume ratio which impedes the study of the anticoagulant properties of the endothelial cells. According to the 3R regulations (reduce, replace and refine animal experimentation) we developed a closed circuit microfluidic in vitro system in which endothelial cells are cultured in 3D round section microchannels and subjected to physiological, pulsatile flow...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29649832/the-impact-of-preexisting-chronic-kidney-disease-on-the-severity-and-recovery-of-acute-kidney-injury
#4
Sung Yoon Lim, Yoon Sook Ko, Hee Young Lee, Ji Hyun Yang, Myung Gyu Kim, Sang Kyung Jo, Won Yong Cho
BACKGROUND: Recent observational studies have shown that in chronic kidney disease (CKD) patients, a significantly smaller percentage of patients with an episode of acute kidney injury (AKI) have full recovery of renal function compared to those without CKD. However, precise mechanisms involved in the incomplete repair after AKI with preexisting CKD have not been completely ascertained. Here, we assessed the impact of preexisting CKD on the severity and recovery of AKI in a mouse model of 5/6 nephrectomy...
April 12, 2018: Nephron
https://www.readbyqxmd.com/read/29649063/ganoderma-lucidum-polysaccharide-peptide-attenuates-skin-flap-ischemia-reperfusion-injury-in-a-thioredoxin-dependent-manner
#5
Huiwen Ren, Xiangbo Meng, Jian Yin, Jingyan Sun, Qingfeng Huang, Zhuming Yin
BACKGROUND: Thioredoxin-1 (Trx-1) plays an important role in defensing the skin flap ischemia-reperfusion injury. Ganoderma lucidum polysaccharide peptide (GLPP) is the major component of Ganoderma lucidum, which possesses potent antioxidant and antiapoptotic activity. Our study aims to determine whether GLPP could attenuate the skin flap ischemia-reperfusion injury and investigate possible mechanisms involved. METHODS: The dermoprotective effect and mechanisms were assessed by an in vivo mouse ischemia-reperfusion flap model and an in vitro epithelial skin cell hypoxia/reoxygenation model...
March 29, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29643981/nephroprotective-effect-of-sonchus-oleraceus-extract-against-kidney-injury-induced-by-ischemia-reperfusion-in-wistar-rats
#6
Liliana Torres-González, Eduardo Cienfuegos-Pecina, Marlene M Perales-Quintana, Gabriela Alarcon-Galvan, Linda E Muñoz-Espinosa, Edelmiro Pérez-Rodríguez, Paula Cordero-Pérez
Introduction: Kidney ischemia-reperfusion (I/R) injury is the main cause of delayed graft function in solid organ transplantation. Sonchus oleraceus is a plant with well-known antioxidant and anti-inflammatory activities; however, its effects on renal I/R are unknown. Objective: To evaluate whether S. oleraceus extract (S.O.e.) has nephroprotective activity in an I/R model in Wistar rats. Materials and Methods: Animal groups ( n = 6): sham, I/R (45 min/15 h), S...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29643809/examination-of-the-role-of-mitochondrial-morphology-and-function-in-the-cardioprotective-effect-of-sodium-nitrite-administered-24-h-before-ischemia-reperfusion-injury
#7
Vivien Demeter-Haludka, Mária Kovács, Alexandra Petrus, Roland Patai, Danina M Muntean, László Siklós, Ágnes Végh
Background: We have previous evidence that in anesthetized dogs the inorganic sodium nitrite protects against the severe ventricular arrhythmias, resulting from coronary artery occlusion and reperfusion, when administered 24 h before. The present study aimed to examine, whether in this effect changes in mitochondrial morphology and function would play a role. Methods: Thirty dogs were infused intravenously either with saline ( n = 15) or sodium nitrite (0.2 μmol/kg/min; n = 15) for 20 min, and 24 h later, 10 dogs from each group were subjected to a 25 min period of occlusion and then reperfusion of the left anterior descending coronary artery...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29643256/critical-role-of-flavin-and-glutathione-in-complex-i-mediated-bioenergetic-failure-in-brain-ischemia-reperfusion-injury
#8
Anja Kahl, Anna Stepanova, Csaba Konrad, Corey Anderson, Giovanni Manfredi, Ping Zhou, Costantino Iadecola, Alexander Galkin
BACKGROUND AND PURPOSE: Ischemic brain injury is characterized by 2 temporally distinct but interrelated phases: ischemia (primary energy failure) and reperfusion (secondary energy failure). Loss of cerebral blood flow leads to decreased oxygen levels and energy crisis in the ischemic area, initiating a sequence of pathophysiological events that after reoxygenation lead to ischemia/reperfusion (I/R) brain damage. Mitochondrial impairment and oxidative stress are known to be early events in I/R injury...
April 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29630131/butorphanol-attenuates-myocardial-ischemia-reperfusion-injury-through-inhibiting-mitochondria-mediated-apoptosis-in-mice
#9
L-H Huang, J Li, J-P Gu, M-X Qu, J Yu, Z-Y Wang
OBJECTIVE: To investigate the role of the opioid receptors agonist butorphanol on mice myocardial ischemia reperfusion (I/R) injury. MATERIALS AND METHODS: The left anterior descending of coronary artery was ligatured for 30 min and then reperfusion for 6 h was performed to mimic the mouse myocardial I/R injury. All mice were randomly divided into three groups: sham group, I/R group and I/R + butorphanol group. Blood samples were collected for the measurement of cardiac troponin I (CTnI) and creatine kinase MB (CK-MB) levels...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29630130/inhibitive-effects-of-microrna-34a-on-protecting-against-ischemia-reperfusion-injury-of-vital-organs-in-hemorrhagic-shock-pregnant-mice
#10
L-B Qin, Z-Y Li, H Li, X-Q Fan, H-G Liu, X-M Dong, W-Y Jia
OBJECTIVE: Hemorrhagic shock is a common vital condition in obstetrics, and major treatment consists of bleeding control and liquid resuscitation. MicroRNA (miR) has been found to regulate multiple diseases. However, its expression profile in hemorrhagic shock or effects on the ischemia-reperfusion injury in pregnant mice has not been reported yet. PATIENTS AND METHODS: This study generated rat hemorrhagic shock pregnant model, on which real-time quantitative PCR was used to measure miR-34a expressions...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29630125/effects-of-sevoflurane-post-conditioning-in-cerebral-ischemia-reperfusion-injury-via-tlr4-nf-%C3%AE%C2%BAb-pathway-in-rats
#11
C-X Shi, Y-B Ding, F Yu J Jin, T Li, J-H Ma, L-Y Qiao, W-Z Pan, K-Z Li
OBJECTIVE: The aim of the study was to investigate the anti-inflammatory effect of sevoflurane post-conditioning on cerebral ischemia-reperfusion injury in rats. MATERIALS AND METHODS: Thirty Sprague Dawley (SD) rats were randomly divided into 3 groups: sham operation group (Sham), ischemia/reperfusion injury (I/R) group and sevoflurane post-conditioning group (Se). Hematoxylin-eosin (HE) staining was used to observe the inflammatory response in the brain tissue...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29629712/l-theanine-protects-h9c2-cells-from-hydrogen-peroxide-induced-apoptosis-by-enhancing-antioxidant-capability
#12
Chengjian Li, Qiongxian Yan, Shaoxun Tang, Wenjun Xiao, Zhiliang Tan
BACKGROUND L-theanine is a non-protein amino acid in green tea, and its hepatoprotection and neuroprotection have been verified. However, whether L-theanine can prevent cardiomyocytes from apoptosis is unclear yet. This study evaluated the protective effects of L-theanine on H2O2-induced heart injury in vitro. MATERIAL AND METHODS The certified H9C2 cells were pretreated with L-theanine (0 mM, 4 mM, 8 mM, and 16 mM) for 24 h, followed by 160 µM H2O2 solution for 4 h. The cell viability and antioxidant indices were assayed...
April 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29627876/naringin-attenuates-cerebral-ischemia-reperfusion-injury-through-inhibiting-peroxynitrite-mediated-mitophagy-activation
#13
Jinghan Feng, Xingmiao Chen, Shengwen Lu, Wenting Li, Dan Yang, Weiwei Su, Xijun Wang, Jiangang Shen
Excessive autophagy/mitophagy plays important roles during cerebral ischemia-reperfusion (I/R) injury. Peroxynitrite (ONOO- ), a representative reactive nitrogen species, mediates excessive mitophagy activation and exacerbates cerebral I/R injury. In the present study, we tested the hypothesis that naringin, a natural antioxidant, could inhibit ONOO- -mediated mitophagy activation and attenuate cerebral I/R injury. Firstly, we demonstrated that naringin possessed strong ONOO- scavenging capability and also inhibited the production of superoxide and nitric oxide in SH-SY5Y cells exposed to 10 h oxygen-glucose-deprivation plus 14 h of reoxygenation or ONOO- donor 3-morpholinosydnonimine conditions...
April 7, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29626425/salidroside-improves-brain-ischemic-injury-by-activating-pi3k-akt-pathway-and-reduces-complications-induced-by-delayed-tpa-treatment
#14
Wei Zuo, Feng Yan, Bo Zhang, Xiaomin Hu, Dan Mei
Cerebral ischemia causes blood-brain barrier (BBB) injury and thus increases the risk of complications secondary to thrombolysis, which limited its clinical application. This study aims to clarify the role and mechanism of salidroside (SALD) in alleviating brain ischemic injury and whether pretreatment of it could improve prognosis of delayed treatment of tissue plasminogen activator (t-PA). Rats were subjected to 3h of middle cerebral artery occlusion (MCAO) and were intraperitoneally administered with 10, 20 or 40mg/kg SALD before ischemia...
April 4, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29626151/metabolomic-profiling-in-acute-st-segment-elevation-myocardial-infarction-identifies-succinate-as-an-early-marker-of-human-ischemia-reperfusion-injury
#15
Matthias Kohlhauer, Sam Dawkins, Ana S H Costa, Regent Lee, Timothy Young, Victoria R Pell, Robin P Choudhury, Adrian P Banning, Rajesh K Kharbanda, Kourosh Saeb-Parsy, Michael P Murphy, Christian Frezza, Thomas Krieg, Keith M Channon
BACKGROUND: Ischemia-reperfusion injury following ST-segment-elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to mitochondrial dysfunction is a major cause of ischemia-reperfusion injury; however, the potential importance and specificity of myocardial succinate accumulation in human STEMI is unknown. We sought to identify the metabolites released from the heart in patients undergoing primary percutaneous coronary intervention for emergency treatment of STEMI...
April 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29625388/crocin-reverses-unilateral-renal-ischemia-reperfusion-injury-induced-augmentation-of-oxidative-stress-and-toll-like-receptor-4-activity
#16
Hadeer O Abou-Hany, Hoda Atef, Eman Said, Hassan A Elkashef, Hatem A Salem
Renal Ischemia (RI) usually develops as a secondary manifestation of hypertension, various cardiovascular disorders and renal transplantation. It exerts hypoxic oxidative stress to kidneys, together with stimulation of several immune-mediated inflammatory cascades. Such events eventually damage renal tubules and glomeruli, driving acute kidney injury (AKI) and ultimately, renal failure. Crocin; the main bioactive constituent of Crocus sativus extract has been reported to demonstrate numerous pharmacological merits...
March 27, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29625260/protective-effects-of-polygonum-multiflorum-on-ischemic-stroke-rat-model-analysed-by-1-h-nmr-metabolic-profiling
#17
Ming-Hui Li, Ling-Yu Ruan, Cheng Chen, Yue-Xiao Xing, Wei Hong, Rong-Hui Du, Jun-Song Wang
Stroke is the third most common cause of death in most industrialized countries. Polygonum multiflorum (He-Shou-Wu, HSW) is one of the traditional Chinese medicines with multiple pharmacological activities which is widely used in Chinese recipe. This study aims to explore the protective effect of HSW on ischemic stroke rat model and to elucidate the underlying mechanisms. The mortality rate, neurological deficit, cerebral infarct size, histopathology, immunohistochemistry, biochemical parameters, quantitative real-time polymerase chain reaction and western blotting were used to access the treatment effects of HSW on ischemic stroke...
March 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29624520/inhibition-of-microrna-429-attenuates-oxygen-glucose-deprivation-reoxygenation-induced-neuronal-injury-by-promoting-expression-of-gata-binding-protein-4
#18
Jie Xiao, Ranran Kong, Jingye Hu
MicroRNAs (miRNAs) have been documented as critical regulators in ischemia/reperfusion-induced neuronal death. A better understanding of miRNA-mediated molecular mechanisms in ischemia/reperfusion-induced neuronal death may provide therapeutic targets for cerebral ischemia/reperfusion injury. A growing body of evidence suggests that miR-429 is a apoptosis-related miRNA that is also induced by hypoxia. However, whether miR-429 is involved in regulating neuronal apoptosis during cerebral ischemia/reperfusion injury remains unclear...
April 5, 2018: Neuroreport
https://www.readbyqxmd.com/read/29623938/delayed-xenon-post-conditioning-mitigates-spinal-cord-ischemia-reperfusion-injury-in-rabbits-by-regulating-microglial-activation-and-inflammatory-factors
#19
Yan-Wei Yang, Yun-Lu Wang, Jia-Kai Lu, Lei Tian, Mu Jin, Wei-Ping Cheng
The neuroprotective effect against spinal cord ischemia/reperfusion injury in rats exerted by delayed xenon post-conditioning is stronger than that produced by immediate xenon post-conditioning. However, the mechanisms underlying this process remain unclear. Activated microglia are the main inflammatory cell type in the nervous system. The release of pro-inflammatory factors following microglial activation can lead to spinal cord damage, and inhibition of microglial activation can relieve spinal cord ischemia/reperfusion injury...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29623935/neuroprotective-effect-of-ischemic-postconditioning-on-sciatic-nerve-transection
#20
Xiao-Bin Zhou, Na Liu, Dong Wang, De-Xin Zou, Chang-Wei Wei, Jun-Lin Zhou
Ischemic preconditioning or postconditioning has been shown to have neuroprotective effect on cerebral ischemia, but it has not been studied in peripheral nerve injury. In this study, a rat model of sciatic nerve transection was established, and subjected to three cycles of ischemia for 10 minutes + reperfusion for 10 minutes, once a day. After ischemic postconditioning, serum insulin-like growth factor 1 expression increased; sciatic nerve Schwann cell myelination increased; sensory function and motor function were restored...
March 2018: Neural Regeneration Research
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