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Ischemia-reperfusion injury

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https://www.readbyqxmd.com/read/29471104/cellular-senescence-as-a-therapeutic-target-to-improve-renal-transplantation-outcome
#1
REVIEW
Hester van Willigenburg, Peter L J de Keizer, Ron W F de Bruin
Kidney transplants from aged donors are more vulnerable to ischemic injury, suffer more from delayed graft function and have a lower graft survival compared to kidneys from younger donors. On a cellular level, aging results in an increase in cells that are in a permanent cell cycle arrest, termed senescence, which secrete a range of pro-inflammatory cytokines and growth factors. Consequently, these senescent cells negatively influence the local milieu by causing inflammaging, and by reducing the regenerative capacity of the kidney...
February 19, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29470356/donor-club-cell-secretory-protein-g38a-polymorphism-is-associated-with-a-decreased-risk-of-primary-graft-dysfunction-in-the-french-cohort-in-lung-transplantation-colt
#2
Angela Hin, Caroline Kannengiesser, Arnaud Roussel, Benjamin Renaud-Picard, Antoine Roux, Martine Reynaud-Gaubert, Johanna Claustre, Adrien Tissot, Romain Guillemain, Jean-François Mornex, Sacha Mussot, Claire Dromer, Marcel Dahan, Olivier Brugière, Olaf Mercier, Raphaël Borie, Marina Pretolani, Yves Castier, Pierre Mordant
BACKGROUND: Club Cell Secretory Protein (CCSP) G38A polymorphism has recently been involved in lung epithelial susceptibility to external injuries. Lung transplantation (LT) is currently limited by ischemia-reperfusion injury leading to Primary Graft Dysfunction (PGD). We thus hypothesized that donor CCSP G38A polymorphism might impact the risk of PGD following LT. METHODS: We focused on LT included in the French multicentric Cohort in Lung Transplantation (COLT), performed between January 2009 and December 2014, and associated with preoperative blood samples from the donor and the recipient...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29470355/effects-of-warm-versus-cold-ischemic-donor-lung-preservation-on-the-underlying-mechanisms-of-injuries-during-ischemia-and-reperfusion
#3
Ilker Iskender, Marcelo Cypel, Tereza Martinu, Manyin Chen, Jin Sakamoto, Hyunhee Kim, Keke Yu, Huiqing Lin, Zehong Guan, Kohei Hashimoto, Thomas K Waddell, Mingyao Liu, Shaf Keshavjee
BACKGROUND: Ischemia-reperfusion injury related to lung transplantation is a major contributor to early postoperative morbidity and mortality. We hypothesized that donation after cardiac death donor lungs experience warm ischemic conditions that activate different injurious mechanisms compared with donor lungs that undergo prolonged cold ischemic conditions. METHODS: Rat donor lungs were preserved under different cold ischemic times (CIT: 12 hours or 18 hours), or under warm ischemia time (WIT: 3 hours) after cardiac death, followed by single left lung transplantation...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29470249/elevated-serum-uric-acid-affects-myocardial-reperfusion-and-infarct-size-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#4
Alessandro Mandurino-Mirizzi, Gabriele Crimi, Claudia Raineri, Silvia Pica, Marta Ruffinazzi, Umberto Gianni, Alessandra Repetto, Marco Ferlini, Barbara Marinoni, Sergio Leonardi, Stefano De Servi, Luigi Oltrona Visconti, Gaetano M De Ferrari, Maurizio Ferrario
AIMS: Elevated serum uric acid (eSUA) was associated with unfavorable outcome in patients with ST-segment elevation myocardial infarction (STEMI). However, the effect of eSUA on myocardial reperfusion injury and infarct size has been poorly investigated. Our aim was to correlate eSUA with infarct size, infarct size shrinkage, myocardial reperfusion grade and long-term mortality in STEMI patients undergoing primary percutaneous coronary intervention. METHODS: We performed a post-hoc patients-level analysis of two randomized controlled trials, testing strategies for myocardial ischemia/reperfusion injury protection...
February 20, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29468596/an-in-vitro-oxygen-glucose-deprivation-model-for-studying-ischemia-reperfusion-injury-of-neuronal-cells
#5
Myoung-Gwi Ryou, Robert T Mallet
Ischemia-reperfusion syndromes of the heart and brain are the leading cause of death and long-term disability worldwide. Development of effective treatments for myocardial infarction, stroke, cardiac arrest and their sequelae requires preclinical models that replicate specific features of ischemia-reperfusion. The complexities of intact animals, including the integrated function of organ systems, autonomic innervation and endocrine factors, often preclude detailed study of specific components of ischemia-reperfusion injury cascades...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29468590/a-murine-model-of-myocardial-ischemia-reperfusion-injury
#6
Zhaobin Xu, Kevin E McElhanon, Eric X Beck, Noah Weisleder
Ligation of the left anterior descending (LAD) coronary artery in the mouse heart is a widely used model to simulate myocardial infarction and ischemia-reperfusion injury. Here we describe a ligation technique routinely performed in our laboratory to induce myocardial infarction that may be used to study ischemia-reperfusion injury in the myocardium. The methods described enhance location of the LAD coronary artery to allow for accurate ligation, thus increasing reproducibility of infarct size and location.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29468175/rapamycin-prevents-cerebral-stroke-by-modulating-apoptosis-and-autophagy-in-penumbra-in-rats
#7
Meiling Wu, Huadan Zhang, Jiejing Kai, Feng Zhu, Jingyin Dong, Ziwei Xu, Michael Wong, Ling-Hui Zeng
Objective: Whether activation or inhibition of the mTOR pathway is beneficial to ischemic injury remains controversial. It may result from the different reaction of ischemic penumbra and core to modulation of mTOR pathway after cerebral ischemia-reperfusion injury in rats. Methods: Longa's middle cerebral artery occlusion (MCAO) method was conducted to induce the focal cerebral ischemia-reperfusion. Western blot analysis was used to examine the protein expression involving mTOR pathway, apoptosis, and autophagy-related proteins...
February 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29467677/ginsenoside-rg1-ameliorates-rat-myocardial-ischemia-reperfusion-injury-by-modulating-energy-metabolism-pathways
#8
Lin Li, Chun-Shui Pan, Li Yan, Yuan-Chen Cui, Yu-Ying Liu, Hong-Na Mu, Ke He, Bai-He Hu, Xin Chang, Kai Sun, Jing-Yu Fan, Li Huang, Jing-Yan Han
As a major ingredient of Radix ginseng , ginsenoside Rg1 (Rg1) has been increasingly recognized to benefit the heart condition, however, the rationale behind the role is not fully understood. In vitro study in H9c2 cardiomyocytes has shown the potential of Rg1 to increase ATP content in the cells. We thus speculated that the protective effect of Rg1 on heart ischemia and reperfusion (I/R) injury implicates energy metabolism regulation. The present study was designed to verify this speculation. Male Sprague-Dawley rats were subjected to 30 min of occlusion of left coronary anterior descending artery followed by reperfusion for 90 min...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29467653/the-antioxidant-activity-of-pistachios-reduces-cardiac-tissue-injury-of-acute-ischemia-reperfusion-i-r-in-diabetic-streptozotocin-stz-induced-hyperglycaemic-rats
#9
Rosanna Di Paola, Roberta Fusco, Enrico Gugliandolo, Ramona D'Amico, Michela Campolo, Saverio Latteri, Arianna Carughi, Giuseppina Mandalari, Salvatore Cuzzocrea
Diabetes mellitus is an important risk factor for the development of heart pathology. Myocardial infarction is the cause of death occurring after prolonged ischemia of the coronary arteries. Restoration of blood flow is the first intervention against heart attack, although the process of restoring blood flow to the ischemic myocardium could cause additional injury. This phenomenon, termed myocardial ischemia-reperfusion (MI-R) injury, is characterized by the formation of oxygen radicals. Pistachios have significant glucose- and insulin-lowering effects and can improve the inflammatory contest by downregulating both the expression and the circulating levels of several metabolic risk markers...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29467553/fish-oil-alleviates-liver-injury-induced-by-intestinal-ischemia-reperfusion-via-ampk-sirt-1-autophagy-pathway
#10
Hui-Rong Jing, Fu-Wen Luo, Xing-Ming Liu, Xiao-Feng Tian, Yun Zhou
AIM: To evaluate whether fish oil (FO) can protect liver injury induced by intestinal ischemia/reperfusion (I/R) via the AMPK/SIRT-1/autophagy pathway. METHODS: Ischemia in Wistar rats was induced by superior mesenteric artery occlusion for 60 min and reperfusion for 240 min. One milliliter per day of FO emulsion or normal saline was administered by intraperitoneal injection for 5 consecutive days to each animal. Animals were sacrificed at the end of reperfusion...
February 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29467431/hypoxia-induced-long-non-coding-rna-malat1-is-dispensable-for-renal-ischemia-reperfusion-injury
#11
Malte Kölling, Celina Genschel, Tamas Kaucsar, Anika Hübner, Song Rong, Roland Schmitt, Inga Sörensen-Zender, George Haddad, Andreas Kistler, Harald Seeger, Jan T Kielstein, Danilo Fliser, Hermann Haller, Rudolf Wüthrich, Martin Zörnig, Thomas Thum, Johan Lorenzen
Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney injury (AKI). Non-coding RNAs are crucially involved in its pathophysiology. We identified hypoxia-induced long non-coding RNA Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) to be upregulated in renal I/R injury. We here elucidated the functional role of Malat1 in vitro and its potential contribution to kidney injury in vivo. Malat1 was upregulated in kidney biopsies and plasma of patients with AKI, in murine hypoxic kidney tissue as well as in cultured and ex vivo sorted hypoxic endothelial cells and tubular epithelial cells...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29466787/a-strategy-for-optimizing-the-combination-of-active-components-based-on-chinese-medicinal-formula-sheng-mai-san-for-myocardial-ischemia
#12
Fang Li, Xiao-Xue Fan, Chun Chu, Yu Zhang, Jun-Ping Kou, Bo-Yang Yu
BACKGROUND/AIMS: Traditional Chinese medicine (TCM) has been used in clinical practice for thousands of years and has accumulated considerable knowledge concerning the in vivo efficacy of targeting complicated diseases. TCM formulae are a mixture of hundreds of chemical components with multiple potential targets, essentially acting as a combination therapy of multi-component drugs. However, the obscure substances and the unclear molecular mechanisms are obstacles to their further development and internationalization...
February 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29466390/the-role-of-complement-activation-in-rhabdomyolysis-induced-acute-kidney-injury
#13
XuDong Huang, Wei Zhao, LiXia Zhang, XinJun Yang, LiHui Wang, YunShuang Chen, JingHua Wang, Chao Zhang, GuangLi Wu
Rhabdomyolysis (RM) may cause kidney damage and results primarily in acute kidney injury (AKI). Complement is implicated in the pathogenesis of renal diseases and ischemia-reperfusion injury (IRI), but the role of complement, especially its activation pathway(s) and its effect in RM-induced AKI, is not clear. This study established a rat model of AKI induced by RM via intramuscular treatment with glycerol. Cobra venom factor (CVF) was administered via tail vein injection to deplete complement 12 h prior to intramuscular injection of glycerol...
2018: PloS One
https://www.readbyqxmd.com/read/29466087/rat-hippocampal-ca3-neuronal-injury-induced-by-limb-ischemia-reperfusion-a-possible-restorative-effect-of-alpha-lipoic-acid
#14
Ola A Hussein, Amel M M Abdel-Hafez, Ayat Abd El Kareim
Limb ischemia reperfusion (I/R) injury is associated with serious local and systemic effects. Reperfusion may augment tissue injury in excess of that produced by ischemia alone. The hippocampus has been reported to be vulnerable to I/R injury. Alpha lipoic acid (ALA) is an endogenous antioxidant with a powerful antioxidative, anti-inflammatory, and antiapoptotic properties. We studied the probable restorative effect of ALA on limb I/R-induced structural damage of rat hippocampus. Forty adult male albino rats were divided equally into four groups: group I (sham); group II (I/R-1 day) has undergone bilateral femoral arteries occlusion (3 h), then reperfusion for 1 day; group III (I/R-7 days) has undergone reperfusion for seven days; group IV (I/R-ALA) has undergone I/R as group III and received an intraperitoneal injection of ALA (100 mg/kg) for 7 days...
March 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29464890/serelaxin-induces-notch1-signaling-and-alleviates-hepatocellular-damage-in-orthotopic-liver-transplantation
#15
Shoichi Kageyama, Kojiro Nakamura, Bibo Ke, Ronald W Busuttil, Jerzy W Kupiec-Weglinski
Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). We have reported on the crucial role of macrophage Notch1 signaling in mouse warm hepatic IRI model. However, its clinical relevance or therapeutic potential remain unknown. Here, we used Serelaxin (SER), to verify Notch1 induction and putative hepatoprotective function in IR-stressed OLT. C57BL/6 mouse livers subjected to extended (18hr) cold storage were transplanted to syngeneic recipients...
February 21, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29464855/luteoloside-attenuates-anoxia-reoxygenation-induced-cardiomyocytes-injury-via-mitochondrial-pathway-mediated-by-14-3-3%C3%AE-protein
#16
Zhantu Liu, Lili Yang, Jiyi Huang, Ping Xu, Zeyu Zhang, Dong Yin, Jichun Liu, Huan He, Ming He
Ischemia/reperfusion (I/R) injury is the major cause of acute cardiovascular disease worldwide. 14-3-3η protein has been demonstrated to protect myocardium against I/R injury. Luteoloside (Lut), a flavonoid found in many Chinese herbs, exerts myocardial protection effects. However, the mechanism remains unclear. We hypothesize that the cardioprotective role of Lut is exerted by regulating the 14-3-3η signal pathway. To investigate our hypothesis, an in vitro I/R model was generated in H9C2 cardiomyocytes by anoxia/reoxygenation (A/R) treatment...
February 21, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29464158/hyperbaric-oxygen-for-ischemia-due-to-injection-of-cosmetic-fillers-case-report-and-issues
#17
Raven Henderson, Debra A Reilly, Jeffrey S Cooper
Natural and synthetic fillers have revolutionized aesthetic facial rejuvenation and soft-tissue augmentation. We present a case highlighting the dangers of filler self-injection. A 37-year-old woman self-injected a dermal filler around both temples. She immediately experienced left--side hearing loss, blanching over the left face, and pain. Prompt treatment with hyaluronidase, topical nitro paste, and warm compresses ensued. An emergency computed tomography angiogram showed occlusion of a superficial temporal artery branch...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29463997/targeting-aldh2-for-therapeutic-interventions-in-chronic-pain-related-myocardial-ischemic-susceptibility
#18
Chen Li, Wanqing Sun, Chunhu Gu, Zheng Yang, Nanhu Quan, Jingrun Yang, Zhaoling Shi, Lu Yu, Heng Ma
Clinical observations have demonstrated a link between chronic pain and increased ischemic heart disease mortality, but the mechanisms remain elusive. Reactive aldehydes have recently been confirmed as a new player in pain pathologies, while our previous study demonstrated that reactive aldehydes (4-HNE) induced carbonyl stress contributing to myocardial ischemic intolerance. The aim of this study was to explore whether chronic pain increases susceptibility to myocardial ischemia/reperfusion (MI/R) injury and to investigate the underlying mechanisms focusing on toxic aldehyde and carbonyl stress...
2018: Theranostics
https://www.readbyqxmd.com/read/29463714/carbon-monoxide-protects-the-kidney-through-the-central-circadian-clock-and-cd39
#19
Matheus Correa-Costa, David Gallo, Eva Csizmadia, Edward Gomperts, Judith-Lisa Lieberum, Carl J Hauser, Xingyue Ji, Binghe Wang, Niels Olsen Saraiva Câmara, Simon C Robson, Leo E Otterbein
Ischemia reperfusion injury (IRI) is the predominant tissue insult associated with organ transplantation. Treatment with carbon monoxide (CO) modulates the innate immune response associated with IRI and accelerates tissue recovery. The mechanism has been primarily descriptive and ascribed to the ability of CO to influence inflammation, cell death, and repair. In a model of bilateral kidney IRI in mice, we elucidate an intricate relationship between CO and purinergic signaling involving increased CD39 ectonucleotidase expression, decreased expression of Adora1, with concomitant increased expression of Adora2a/2b...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29462717/evaluating-the-impact-of-diabetes-and-diabetic-cardiomyopathy-rat-heart-on-the-outcome-of-ischemia-reperfusion-associated-oxidative-stress
#20
A Mahalakshmi, Gino A Kurian
Earlier literature underlines that oxidative stress plays a major role in the pathology of myocardial ischemia-reperfusion (I/R) injury, diabetic cardiomyopathy (DCM), diabetes mellitus (DM), fibrosis and hypertrophy which could adversely affect the normal cardiac function. However, the contributory role of oxidative stress in I/R pathology of heart with pre-existing abnormalities or diseases like DM and DCM remains to be explored. I/R injury was induced in normal (normal diet), DM (normal diet + streptozotocin: multiple low dose of 30mg/kg) and DCM (high fat diet (40% fat) + streptozotocin: multiple low dose of 30mg/kg) rat hearts using Langendorff isolated heart perfusion apparatus...
February 17, 2018: Free Radical Biology & Medicine
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