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Reviews in oncology

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https://www.readbyqxmd.com/read/29053029/the-evidence-on-effectiveness-of-weekly-vs-triweekly-cisplatin-concurrent-with-radiotherapy-in-locally-advanced-head-and-neck-squamous-cell-carcinoma-hnscc-a-systematic-review-and-meta-analysis
#1
Jc Kennetth Jacinto, Jayson Co, Michael Benedict Mejia, Eugenio Emmanuel Regala
OBJECTIVE: This study aims to synthesize the current available evidences on the effectiveness of weekly vs triweekly cisplatin concurrent with radiotherapy in the primary and adjuvant treatment of locally advanced head and neck squamous cell carcinoma (HNSCC). METHODS: A systematic review and meta-analysis of literature were undertaken to assess the effectiveness of weekly vs triweekly schedule in primary and adjuvant treatment for HNSCC with adverse risk features...
November 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29051734/overview-on-patient-centricity-in-cancer-care
#2
Šarunas Narbutas, Kristina York, Barry D Stein, Kara Magsanoc-Alikpala, Yoshiyuki Majima, Zoltan Kalo, Timea Almasi, Andras Inotai
Successful implementation of treatment in cancer care partially depends on how patients' perspectives are taken into account, as preferences of health care professionals and patients may differ. Objectives of this exploratory research were (I) to identify patient preferences and values (PPVs) in cancer care as indicated by patient organizations (POs), (II) to determine how these PPVs are captured in cancer care guidelines and (III) to review how guidelines take into account these PPVs. Based on a survey developed and completed by 19 POs, a literature review was conducted to analyse how patient perspectives are incorporated in oncology treatment guidelines...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29051324/corneal-complications-after-orbital-radiotherapy-for-primary-epithelial-malignancies-of-the-lacrimal-gland
#3
Sri K Gore, Nicholas P Plowman, Aruna Dharmasena, David H Verity, Geoffrey E Rose
PURPOSE: To review the long-term corneal complications after high-dose external beam orbital radiotherapy given to patients for lacrimal gland carcinomas. The impact of prophylactic measures to improve long-term ocular surface health is also assessed. DESIGN: Retrospective case series. PARTICIPANTS: Patients under the care of Moorfields Eye Hospital and receiving external beam radiotherapy for primary epithelial lacrimal gland carcinoma between 1975 and 2014...
October 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29051029/recent-advances-in-localized-rcc-a-focus-on-vegf-and-immuno-oncology-therapies
#4
REVIEW
Pearl Subramanian, Naomi B Haas Md
Recent advances in advanced renal cell cancer (RCC) research have produced new drugs and therapies for patients with metastatic disease leading to higher response rates, improvements in progression-free survival, and longer overall survival. These advances have yet to be realized in patients with early-stage kidney cancer, and to date, no drug has been approved for the adjuvant treatment of localized kidney cancer. The current standard of care for localized high-risk kidney cancers is resection of the primary tumor...
October 16, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29049462/association-of-surgical-approach-and-margin-status-with-oncologic-outcomes-following-gross-total-resection-for-sinonasal-melanoma
#5
Zafar Sayed, Jocelyn C Migliacci, Jennifer R Cracchiolo, Christopher A Barker, Nancy Y Lee, Sean M McBride, Viviane S Tabar, Ian Ganly, Snehal G Patel, Luc T Morris, Benjamin R Roman, Alexander N Shoushtari, Marc A Cohen
Importance: Sinonasal mucosal melanoma (SMM) is a rare malignant neoplasm characterized by a poor prognosis despite aggressive intervention including wide surgical resection. Margin status has previously been cited as an important prognostic factor for local control and overall survival (OS) in patients who undergo either an open or endoscopic surgical approach. No comparisons have been made, however, in patients who have undergone gross total resection with or without positive margins...
October 19, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29048688/is-endoprosthetic-replacement-of-the-proximal-femur-appropriate-in-the-comorbid-patient
#6
Arun Khajuria, Jonathon Ward, George Cooper, Jonathon Stevenson, Michael Parry, Lee Jeys
INTRODUCTION: Patients with failed hip arthroplasty requiring extensive femoral reconstruction often present with a multitude of comorbidities. Many treatment options limit initial mobilisation relying on bone graft incorporation. The use of endoprosthetic replacement (EPR), despite often being a "last resort", offers an expeditious solution with early mobilisation that is crucial in the comorbid individual. Many perceive that the surgical insult of EPR is associated with an increased mortality...
October 16, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29047353/precision-medicine-for-all-challenges-and-opportunities-for-a-precision-medicine-approach-to-critical-illness
#7
REVIEW
Christopher W Seymour, Hernando Gomez, Chung-Chou H Chang, Gilles Clermont, John A Kellum, Jason Kennedy, Sachin Yende, Derek C Angus
All of medicine aspires to be precise, where a greater understanding of individual data will lead to personalized treatment and improved outcomes. Prompted by specific examples in oncology, the field of critical care may be tempted to envision that complex, acute syndromes could bend to a similar reductionist philosophy-where single mutations could identify and target our critically ill patients for treatment. However, precision medicine faces many challenges in critical care. These include confusion about terminology, uncertainty about how to divide patients into discrete groups, the challenges of multi-morbidity, scale, and the need for timely interventions...
October 18, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29047108/clinicopathologic-characteristics-and-outcomes-of-transformed-diffuse-large-b-cell-lymphoma-in-hepatitis-c-virus-infected-patients
#8
Jeff Hosry, Roberto N Miranda, Felipe Samaniego, Minas P Economides, Harrys A Torres
Hepatitis C virus (HCV) causes a chronic but curable infection associated with the development of marginal zone lymphoma (MZL) and diffuse large B-cell lymphoma (DLBCL). Preliminary data have shown frequent transformation of indolent lymphoma to DLBCL in HCV-infected patients. To compare their clinicopathologic characteristics and oncologic outcomes, we reviewed the medical records and pathology reports of HCV-infected and uninfected patients with DLBCL that transformed from indolent lymphoma seen at The University of Texas MD Anderson Cancer Center (June 2004-May 2015)...
October 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29046676/therapeutic-antibodies-what-have-we-learnt-from-targeting-cd20-and-where-are-we-going
#9
REVIEW
Michael J E Marshall, Richard J Stopforth, Mark S Cragg
Therapeutic monoclonal antibodies (mAbs) have become one of the fastest growing classes of drugs in recent years and are approved for the treatment of a wide range of indications, from cancer to autoimmune disease. Perhaps the best studied target is the pan B-cell marker CD20. Indeed, the first mAb to receive approval by the Food and Drug Administration for use in cancer treatment was the CD20-targeting mAb rituximab (Rituxan(®)). Since its approval for relapsed/refractory non-Hodgkin's lymphoma in 1997, rituximab has been licensed for use in the treatment of numerous other B-cell malignancies, as well as autoimmune conditions, including rheumatoid arthritis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29046165/long-term-use-of-nimotuzumab-in-combination-with-intensity-modulated-radiotherapy-and-chemotherapy-in-the-treatment-of-locoregionally-advanced-nasopharyngeal-carcinoma-experience-of-a-single-institution
#10
Wang Fangzheng, Jiang Chuner, Ye Zhiming, Liu Tongxin, Yan Fengqin, Wang Lei, Li Bin, Hu Fujun, Chen Ming, Qin Weifeng, Fu Zhenfu
In this retrospective review of a single institution's experience, the efficacy and safety of the long-term use of nimotuzumab in combination with intensity-modulated radiotherapy (IMRT) and chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma (NPC) were studied. Between August 2008 and March 2014, 39 newly diagnosed patients with stage III–IV NPC were treated with IMRT, chemotherapy, and nimotuzumab. Twenty patients were diagnosed with stage III (51.3%), 14 with stage IVA (35.9%), and 5 with stage IVB (12...
October 18, 2017: Oncology Research
https://www.readbyqxmd.com/read/29045525/clinical-benefit-of-systemic-treatment-in-patients-with-advanced-pancreatic-and-gastro-intestinal-neuroendocrine-tumours-according-to-esmo-mcbs-and-asco-framework
#11
L D de Hosson, L M van Veenendaal, Y Schuller, W T Zandee, W W de Herder, M E T Tesselaar, H J Klümpen, A M E Walenkamp
BackgroundAssessment of clinical benefit of systemic treatments of rare diseases including gastroenteropancreatic neuroendocrine tumors (GEP-NET) is challenging. Recently several tools have been developed to grade clinical benefit of cancer drugs. European Society for Medical Oncology (ESMO) has developed the ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS). The American Society of Clinical Oncology (ASCO) developed and revised the ASCO framework consisting of the Net Health Benefit (NHB) score juxtaposed against the costs of the treatment...
September 26, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045516/navigating-the-highlights-of-phase-iii-trials-a-watchful-eye-on-evidence-based-radiotherapy
#12
J C Trone, S Espenel, A Rehailia-Blanchard, E Guillaume, N Vial, C Rancoule, C Rodriguez-Lafrasse, M Ben Mrad, A El Meddeb Hamrouni, E Ollier, C Chargari, E Deutsch, A Vallard, N Magné
Background: Phase III randomized controlled trials (RCTs) are the cornerstone of evidence-based oncology. However, there is no exhaustive review describing the radiotherapy RTCs characteristics. The objective of the present study was to describe features of all phase III RCTs including at least a radiation therapy. Methods and materials: Requests were performed in the Medline database (via PubMed). The latest update was performed in April 2016, using the following MESH terms: 'clinical trials: phase III as topic', 'radiotherapy', 'brachytherapy', as keywords...
July 12, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29044660/real-world-treatment-patterns-and-outcomes-among-metastatic-cutaneous-melanoma-patients-treated-with-ipilimumab
#13
P M Mohr, P A Ascierto, A A Arance, G M McArthur, A H Hernaez, P K Kaskel, R S Shinde, K S Stevinson
BACKGROUND: There is a scarcity of real-world data on treatment patterns and outcomes among advanced melanoma patients treated with immunotherapies including ipilimumab, an anti-CTLA-4 antibody approved since 2011. OBJECTIVE: To evaluate ipilimumab and post-ipilimumab treatment patterns and outcomes among patients with advanced melanoma in Australia, Germany, Italy and Spain following regulatory approval. METHODS: Retrospective multicentre, multinational, observational chart review study...
October 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29042387/nature-based-care-opportunities-and-barriers-in-oncology-contexts-a-modified-international-e-delphi-survey
#14
Sarah Blaschke, Clare C O'Callaghan, Penelope Schofield
OBJECTIVE: To develop recommendations regarding opportunities and barriers for nature-based care in oncology contexts using a structured knowledge generation process involving relevant healthcare and design experts. DESIGN: Four-round modified electronic Delphi study. Oncology patients' nature-based recommendations, uncovered in preceding qualitative investigation, were included in the first round for the expert participants' consideration. Key items (opportunities and barriers) were developed using data aggregation and synthesis, followed by item prioritisation and 10-point Likert scale ranking (1=not important, 10=very important)...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29042252/the-roles-and-applications-of-autoantibodies-in-progression-diagnosis-treatment-and-prognosis-of-human-malignant-tumours
#15
REVIEW
Jing Wu, Xiaobo Li, Wuqi Song, Yong Fang, Li Yu, Siyuan Liu, Leonid P Churilov, Fengmin Zhang
The existence of autoantibodies towards an individual's own proteins or nucleic acids has been established for more than 100years, and for a long period, these autoantibodies have been believed to be closely associated with autoimmune diseases. However, in recent years, researchers have become more interested in the role and application of autoantibodies in progression, diagnosis, treatment and prognosis of human malignant tumours. Over the past few decades, numerous epidemiological studies have shown that the risk of certain cancers is significantly altered (increased or decreased) in patients with autoimmune diseases, which suggests that autoantibodies may play either promoting or suppressing roles in cancer progression...
October 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29042169/percutaneous-cryoablation-of-renal-cell-carcinoma-with-sinus-vein-involvement-based-on-preprocedural-imaging
#16
Thomas D Atwell, A Nicholas Kurup, Stephen A Boorjian, John J Schmitz, R Houston Thompson, Bradley C Leibovich, Grant D Schmit
PURPOSE: To assess feasibility, safety, and oncologic outcomes of cryoablation in treatment of renal cell carcinoma (RCC) with extension into adjacent renal sinus vein. MATERIALS AND METHODS: Review of an internally maintained renal ablation registry identified 7 patients (4 men and 3 women; median age 62 y; age range, 45-91 y) who underwent percutaneous cryoablation of RCC with imaging consistent with extension of tumor into an immediately adjacent renal sinus vein...
October 14, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29040677/navigation-linked-heads-up-display-in-intracranial-surgery-early-experience
#17
Justin R Mascitelli, Leslie Schlachter, Alexander G Chartrain, Holly Oemke, Jeffrey Gilligan, Anthony B Costa, Raj K Shrivastava, Joshua B Bederson
BACKGROUND: The use of intraoperative navigation during microscope cases can be limited when attention needs to be divided between the operative field and the navigation screens. Heads-up display (HUD), also referred to as augmented reality, permits visualization of navigation information during surgery workflow. OBJECTIVE: To detail our initial experience with HUD. METHODS: We retrospectively reviewed patients who underwent HUD-assisted surgery from April 2016 through April 2017...
October 10, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29040258/prognostic-and-therapeutic-implications-of-dna-repair-gene-mutations-in-advanced-prostate-cancer
#18
Michael T Schweizer, Emmanuel S Antonarakis
Recent work directed toward understanding the molecular features of advanced prostate cancers has revealed a relatively high incidence of both germline and somatic alterations in genes involved in DNA damage repair (DDR). Many of these alterations likely play a critical role in the pathogenesis of more aggressive prostate cancers-leading to genomic instability and an increased probability of the development of lethal disease. However, because the ability to repair DNA damage with a high degree of fidelity is critical to an individual cell's survival, tumor cells harboring alterations in DDR pathway genes are also more susceptible to drugs that induce DNA damage or impair alternative DNA repair pathways...
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29040184/proceedings-from-the-1st-international-conference-current-concepts-and-controversies-in-gynecologic-and-urologic-oncology
#19
Olga Matylevich, Sergey Mavrichev, Andrei Pletnev, Alesya Evmenenko, Aleksey Shevchuk, Valentina Suslova, Sergey Taranenko, Elena Dolomanova, Dmitry Rovsky, Anna Portyanko, Jubilee Brown, Robert Wendel Naumann, Kathleen Schmeler, Anna Plotkin, Sophia Michaelson, Mary Eiken, Edward Trimble, Thomas Randall
The N.N. Alexandrov National Cancer Center of Belarus organized a collaborative international conference entitled 'Current Concepts and Controversies in Gynecologic and Urologic Oncology' with the International Gynecologic Cancer Society and the United States National Cancer Institute. International, regional, and national experts presented recent developments and local conditions in the treatment of gynecologic cancers. Findings were reviewed with the intent of optimizing the management of women with gynecologic cancers across the Commonwealth of Independent States region...
October 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29039897/biochemical-recurrence-after-radical-prostatectomy-what-does-it-mean
#20
Rafael Tourinho-Barbosa, Victor Srougi, Igor Nunes-Silva, Mohammed Baghdadi, Gregory Rembeyo, Sophie S Eiffel, Eric Barret, Francois Rozet, Marc Galiano, Xavier Cathelineau, Rafael Sanchez-Salas
BACKGROUND: Radical prostatectomy (RP) has been used as the main primary treatment for prostate cancer (PCa) for many years with excellent oncologic results. However, approximately 20-40% of those patients has failed to RP and presented biochemical recurrence (BCR). Prostatic specific antigen (PSA) has been the pivotal tool for recurrence diagnosis, but there is no consensus about the best PSA threshold to define BCR until this moment. The natural history of BCR after surgical procedure is highly variable, but it is important to distinguish biochemical and clinical recurrence and to find the correct timing to start multimodal treatment strategy...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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