keyword
https://read.qxmd.com/read/38546948/amphipathic-phenylalanine-induced-nucleophilic-hydrophobic-interface-toward-highly-reversible-zn-anode
#21
JOURNAL ARTICLE
Anbin Zhou, Huirong Wang, Fengling Zhang, Xin Hu, Zhihang Song, Yi Chen, Yongxin Huang, Yanhua Cui, Yixiu Cui, Li Li, Feng Wu, Renjie Chen
Aqueous Zn2+ -ion batteries (AZIBs), recognized for their high security, reliability, and cost efficiency, have garnered considerable attention. However, the prevalent issues of dendrite growth and parasitic reactions at the Zn electrode interface significantly impede their practical application. In this study, we introduced a ubiquitous biomolecule of phenylalanine (Phe) into the electrolyte as a multifunctional additive to improve the reversibility of the Zn anode. Leveraging its exceptional nucleophilic characteristics, Phe molecules tend to coordinate with Zn2+ ions for optimizing the solvation environment...
March 28, 2024: Nano-Micro Letters
https://read.qxmd.com/read/38546929/pd-like-pathogenesis-in-caenorhabditis-elegans-intestinally-infected-with-nocardia-farcinica-and-the-underlying-molecular-mechanisms
#22
JOURNAL ARTICLE
Wenwen Liu, Wenhui Zhou, Peiji Zhao, Tingting Wu, Huan Gu, Yixin Li, Chidi Zhong, Hua Bai, Ninghui Zhao, Xiaowei Huang
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the abnormal aggregation of α-synuclein (α-syn) and the loss of dopaminergic neurons. Although microbial infection has been implicated in the pathogenesis of PD, the associated virulence factors and the underlying molecular mechanisms require further elucidation. Here, we found that intestinal infection with Nocardia farcinica induced a series of PD-like symptoms in Caenorhabditis elegans, such as the accelerated degeneration of dopaminergic neurons, impaired locomotion capacity, and enhanced α-syn aggregation, through the disturbance of mitochondrial functions...
March 28, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38546892/influence-of-degree-of-substitution-on-the-hydroxypropyl-%C3%AE-cyclodextrin-complexation-with-rifampicin-in-water-solution-a-molecular-simulation
#23
JOURNAL ARTICLE
Elena Alvira
CONTEXT: Hydroxypropyl-β-cyclodextrin (HPβCD) is one of the derivatized cyclodextrins most widely used as an excipient in the pharmaceutical industry, for its capacity to improve certain drugs properties. Different configurations of HPβCD are possible depending on the number and location of the 2-hydroxypropyl groups substituted on the glucose rings. Rifampicin has become the most commonly clinically used antibiotic against tuberculosis in recent years, despite its low solubility and variable bioavailability...
March 28, 2024: Journal of Molecular Modeling
https://read.qxmd.com/read/38546888/determining-climate-classifications-and-producing-climate-border-maps-with-gis-of-safranbolu-district-karab%C3%A3-k-t%C3%A3-rkiye
#24
JOURNAL ARTICLE
Hulya Keskin Citiroglu
Knowing climate characteristics enables the detection of particular climate characteristics and their boundaries. This situation is essential in terms of providing sustainable use of areal resources and directing land use plans. For this reason, in this study, climate boundary maps of the Safranbolu district were created based on the need to form a basis for planning. For this purpose, measurement data of all meteorological stations in the district for the last 30 years were obtained; data were associated with the location, and the water balance of each station was calculated using the Thornthwaite climate classification method...
March 28, 2024: Environmental Monitoring and Assessment
https://read.qxmd.com/read/38546823/drug-polymer-nanodroplet-formation-and-morphology-drive-solubility-enhancement-of-gdc-0810
#25
JOURNAL ARTICLE
Kaylee E Barr, Monica L Ohnsorg, Lucy Liberman, Louis G Corcoran, Apoorva Sarode, Karthik Nagapudi, Christina R Feder, Frank S Bates, Theresa M Reineke
Nanodroplet formation is important to achieve supersaturation of active pharmaceutical ingredients (APIs) in an amorphous solid dispersion. The aim of the current study was to explore how polymer composition, architecture, molar mass, and surfactant concentration affect polymer-drug nanodroplet morphology with the breast cancer API, GDC-0810. The impact of nanodroplet size and morphology on dissolution efficacy and drug loading capacity was explored using polarized light microscopy, dynamic light scattering, and cryogenic transmission electron microscopy...
March 28, 2024: Bioconjugate Chemistry
https://read.qxmd.com/read/38546809/comparative-genetic-and-pathogenic-approaches-of-escherichia-coli-isolated-simultaneously-from-pyometra-and-urine-of-bitches
#26
JOURNAL ARTICLE
Cassiane Elisabete Lopes, Tainara Soares Weyh, Camila Azevedo Moni, Maria Eduarda Dias, Tania Aparecida Tardelli Gomes, Mateus Matiuzzi da Costa, Rommel Thiago Jucá Ramos, Aristóteles Góes-Neto, Vasco Ariston de Carvalho Azevedo, Bertram Brenig, Franciele Maboni Siqueira
Escherichia coli (E. coli) are widely related to pyometra and cystitis in dogs, and these infections can occur simultaneously. The goal of this study was to determine genetic and pathogenic insights of 14 E. coli isolated simultaneously from pyometra content and bladder urine of seven bitches. To achieve this, in silico and in vitro comparative analyses were conducted. Whole-genome comparisons demonstrated that E. coli isolated from pyometra and urine of the same animal were predominantly genetic extraintestinal E...
March 28, 2024: Veterinary Research Communications
https://read.qxmd.com/read/38546609/in-vitro-assays-for-immuno-oncology-drug-efficacy-assessment-and-screening-for-personalized-cancer-therapy-scopes-and-challenges
#27
REVIEW
Marufur Rahman, Greg Wells, Juha K Rantala, Thomas Helleday, Munitta Muthana, Sarah J Danson
INTRODUCTION: Immunotherapies have revolutionized cancer treatment, but often fail to produce desirable therapeutic outcomes in all patients. Due to the inter-patient heterogeneity and complexity of the tumor microenvironment, personalized treatment approaches are gaining demand. Researchers have long been using a range of in-vitro assays including 2D models, organoid co-cultures, and cancer-on-a-chip platforms for cancer drug screening. A comparative analysis of these assays with their suitability, high-throughput capacity, and clinical translatability is required for optimal translational use...
March 28, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38546580/on-parrots-delay-of-gratification-executive-function-and-how-sometimes-we-do-the-best-we-can
#28
JOURNAL ARTICLE
Michael J Beran
Engaging executive functions provides an individual with the means to engage in cognitive control by adjusting to the environment and processing information in a way that leads to optimal outcomes. There are some claims that explicit training on certain executive functioning abilities provides benefits beyond the training tasks, but other studies indicate that this may not be true or may be limited based on age and other factors. This same mixed pattern has been reported with nonhuman species, where training or even experience in one specific area, like inhibition, sometimes leads to positive transfer in new but similar tasks that presumably also require executive functions...
February 2024: Journal of Comparative Psychology
https://read.qxmd.com/read/38546571/biological-basis-of-temperament-respiratory-sinus-arrhythmia-and-inhibitory-control-across-childhood
#29
JOURNAL ARTICLE
H Melis Yavuz, Emma Galarneau, Ruth Speidel, Tyler Colasante, Tina Malti
Temperamental inhibitory control is a foundational capacity for children's social, emotional, and behavioral development. Even though temperament is suggested to have a biological basis, the physiological indicators of inhibitory control remain unclear amid mixed empirical results. In this study, we leveraged a multicohort longitudinal design to examine resting respiratory sinus arrhythmia (RSA) as a physiological correlate of inhibitory control across the early and middle childhood years. Data were collected annually across four time points from cohorts of 4- ( n = 150, M age = 4...
March 28, 2024: Developmental Psychology
https://read.qxmd.com/read/38546545/template-free-self-assembly-of-hollow-microtubular-covalent-organic-frameworks-for-oral-delivery-of-insulin
#30
JOURNAL ARTICLE
Lihui Dai, Fang Wu, Yi Xiao, Qian Liu, Meng Meng, Rimo Xi, Yongmei Yin
Covalent organic frameworks (COFs) have demonstrated versatile application potential since their discovery. Although the structure of COFs is orderly arranged, the synthesis of controllable macrostructures still faces challenges. Herein, we report, to our knowledge, the first template-free self-assembled COF-18 Å hollow microtubule (MT-COF-18 Å) structure and its use for insulin delivery that exhibits high loading capacity, gastroresistance, and glucose-responsive properties. The hollow MT-COF-18 Å was achieved by a template-free method benefiting from the mixed solvents of mesitylene and dioxane...
March 28, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38546507/exploring-the-clinical-relevance-of-angico-gum-an-effective-biopolymer-for-topical-protection-of-oesophageal-mucosa-in-gastroesophageal-reflux-disease-patients
#31
JOURNAL ARTICLE
Rudy Diavila Bingana, Lucas Antonio Duarte Nicolau, Thiago Meneses Araújo Leite Sales, Suliana Mesquita Paula, João Pedro do Carmo Neto, Isabela Araújo Linhares Castro, Luiz Fernando Lopes Soares Teixeira, Alvaro Xavier Franco, Fábio de Oliveira Silva Ribeiro, Regina Célia Monteiro de Paula, Jand Venes Rolim Medeiros, Durcilene Alves da Silva, Daniel Sifrim, Marcellus Henrique Loiola Ponte Souza
OBJECTIVES: Angico gum (AG) (Anadenanthera colubrina var. Cebil [Griseb.] Altschul) is utilized by some Brazilian communities to alleviate symptoms from gastroesophageal reflux disease. Here, we aimed to investigate the "in vitro" topical protective capacity of AG on human esophageal mucosa. METHODS: Biopsies of the distal esophageal mucosa were collected from 35 patients with heartburn (24 non-erosive and 11 with erosive oesophagitis (EE)) and mounted in Üssing chambers...
March 28, 2024: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/38546410/interface-targeting-carrier-catalytic-integrated-design-contributing-to-lithium-dihalide-rich-sei-toward-high-interface-stability-for-long-life-solid-state-lithium-metal-batteries
#32
JOURNAL ARTICLE
Xuan Yi Zhou, Fen Fen Huang, Xue Dong Zhang, Biao Zhang, Ying Jie Cui, Ze Hua Wang, Qiong Yang, Zeng Sheng Ma, Jun Liu
The generation of solid electrolyte interphase (SEI) largely determines the comprehensive performance of all-solid-state batteries. Herein, a novel "carrier-catalytic" integrated design is strategically exploited to in situ construct a stable LiF-LiBr rich SEI by improving the electron transfer kinetics to accelerate the bond-breaking dynamics. Specifically, the high electron transport capacity of Br-TPOM skeleton increases the polarity of C-Br, thus promoting the generation of LiBr...
March 28, 2024: Angewandte Chemie
https://read.qxmd.com/read/38546403/the-necroptosis-related-signature-and-tumor-microenvironment-immune-characteristics-associated-with-clinical-prognosis-and-drug-sensitivity-analysis-in-stomach-adenocarcinoma
#33
JOURNAL ARTICLE
Biao Yang, Yingnan Wang, Tao Liu, Meijing Zhang, Tianhang Luo
PURPOSE: Necroptosis plays an important role in the tumorigenesis, development, metastasis, and drug resistance of malignant tumors. This study explored the new model for assessing stomach adenocarcinoma (STAD) prognosis and immunotherapy by combining long noncoding RNAs associated with necroptosis. METHODS: Patient clinical data and STAD gene expression profiles were curated from The Cancer Genome Atlas (TCGA). Immune-related genes were sourced from a specialized molecular database...
March 27, 2024: Aging
https://read.qxmd.com/read/38546373/the-association-between-hemoglobin-levels-and-renal-function-parameters-during-normothermic-machine-perfusion-a-retrospective-cohort-study-using-porcine-kidneys
#34
JOURNAL ARTICLE
L Annick van Furth, Tobias M Huijink, L Leonie van Leeuwen, Hanno Maassen, Veerle A Lantinga, Baran Ogurlu, Tim L Hamelink, Merel B F Pool, Rianne Schutter, Susanne Z J Veldhuis, Petra J Ottens, Cyril Moers, Stefan P Berger, Henri G D Leuvenink, Rene A Posma, Leonie H Venema
BACKGROUND: Ex vivo normothermic machine perfusion (NMP) is a promising tool for assessing an isolated kidney prior to transplantation. However, there is no consensus on the perfusate's optimal oxygen-carrying capacity to support renal function. To investigate the association of hemoglobin levels with renal function parameters, a retrospective analysis of isolated, normothermically, perfused porcine kidneys was performed. METHODS: Between 2015 and 2021, a total of 228 kidneys underwent 4 h of NMP with perfusates that varied in hemoglobin levels...
March 28, 2024: Artificial Organs
https://read.qxmd.com/read/38546288/nutritional-aspects-of-prehabilitation-in-adults-with-cirrhosis-awaiting-liver-transplant
#35
JOURNAL ARTICLE
Christofer Cruz, Carla M Prado, Chelsia Gillis, Robert Martindale, Chantal Bémeur, Jennifer C Lai, Puneeta Tandon
Malnutrition, sarcopenia (low muscle mass), and physical frailty have gained increasing recognition in candidates for liver transplant (LT) as these conditions can impact postoperative functional capacity. Multidimensional prehabilitation programs have been proposed as a safe intervention in adults awaiting LT but the nutritional pillar of prehabilitation has been understudied. This review summarizes the nutritional recommendations for prehabilitation for individuals with cirrhosis awaiting LT. Three major aspects of nutritional prehabilitation are discussed: (1) Assess: Evaluate nutritional status and assess for malnutrition, sarcopenia, and frailty to guide the nutritional prehabilitation intervention intensity, increasing across universal, targeted, and specialist levels; (2) Intervene: Prescribe a nutritional prehabilitation intervention to meet established nutrition guidelines in cirrhosis with a targeted focus on improving nutritional status and muscle health; (3) Reassess: Follow-up based on the required intensity of nutritional care with as needed intervention adjustment...
March 28, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38546268/chemical-kinetic-study-of-the-reaction-of-ch-2-oo-with-ch-3-o-2
#36
JOURNAL ARTICLE
Wen Chao, Charles R Markus, Mitchio Okumura, Frank A F Winiberg, Carl J Percival
Criegee intermediates play an important role in the oxidizing capacity of the Earth's troposphere. Although extensive studies have been conducted on Criegee intermediates in the past decade, their kinetics with radical species remain underexplored. We investigated the kinetics of the simplest Criegee intermediate, CH2 OO, with the methyl peroxy radical, CH3 O2 , as a model system to explore the reactivities of Criegee intermediates with peroxy radicals. Using a multipass UV-Vis spectrometer coupled to a pulsed-laser photolysis flow reactor, CH2 OO and CH3 O2 were generated simultaneously from the photolysis of CH2 I2 /CH3 I/O2 /N2 mixtures with CH2 OO measured directly near 340 nm...
March 28, 2024: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/38546228/white-opaque-switching-in-candida-albicans-cell-biology-regulation-and-function
#37
REVIEW
David R Soll
SUMMARY Candida albicans remains a major fungal pathogen colonizing humans and opportunistically invading tissue when conditions are predisposing. Part of the success of C. albicans was attributed to its capacity to form hyphae that facilitate tissue invasion. However, in 1987, a second developmental program was discovered, the "white-opaque transition," a high-frequency reversible switching system that impacted most aspects of the physiology, cell architecture, virulence, and gene expression of C. albicans ...
March 28, 2024: Microbiology and Molecular Biology Reviews: MMBR
https://read.qxmd.com/read/38546216/influence-of-epicardial-adipose-tissue-inflammation-and-adipocyte-size-on-postoperative-atrial-fibrillation-in-patients-after-cardiovascular-surgery
#38
JOURNAL ARTICLE
Hiroyuki Natsui, Masaya Watanabe, Takashi Yokota, Satonori Tsuneta, Yoshizuki Fumoto, Haruka Handa, Matsushima Shouji, Jiro Koya, Kotaro Nishino, Daishiro Tatsuta, Takuya Koizumi, Takahide Kadosaka, Motoki Nakao, Taro Koya, Taro Temma, Yoichi M Ito, Hatanaka C Kanako, Yutaka Hatanaka, Shingu Yasushige, Satoru Wakasa, Shuhei Miura, Takahiko Masuda, Naritomo Nishioka, Shuichi Naraoka, Kayoko Ochi, Tomoko Kudo, Tsugumine Ishikawa, Toshihisa Anzai
Epicardial adipose tissue (EAT) is an active endocrine organ that is closely associated with occurrence of atrial fibrillation (AF). However, the role of EAT in the development of postoperative AF (POAF) remains unclear. We aimed to investigate the association between EAT profile and POAF occurrence in patients who underwent cardiovascular surgery. We obtained EAT samples from 53 patients to evaluate gene expression, histological changes, mitochondrial oxidative phosphorylation (OXPHOS) capacity in the EAT, and protein secretion in EAT-conditioned medium...
March 2024: Physiological Reports
https://read.qxmd.com/read/38546211/exploring-the-therapeutic-potential-of-dv-b-120-as-an-inhibitor-of-dengue-virus-infection
#39
JOURNAL ARTICLE
Yi-Jung Huang, Tian-Lu Cheng, Yen-Tseng Wang, Chien-Shu Chen, Yu-Ling Leu, Chih-Shiang Chang, Cheng-Han Ho, Shi-Wei Chao, Chia-Tse Li, Chih-Hung Chuang
Dengue fever, an infectious disease prevalent in subtropical and tropical regions, currently lacks effective small-molecule drugs as treatment. In this study, we used a fluorescence peptide cleavage assay to screen seven compounds to assess their inhibition of the dengue virus (DENV) NS2B-NS3 protease. DV-B-120 demonstrated superior inhibition of NS2B-NS3 protease activity and lower toxicity compared to ARDP0006. The selectivity index of DV-B-120 was higher than that of ARDP0006. In vivo assessments of the antiviral efficacy of DV-B-120 against DENV replication demonstrated delayed mortality of suckling mice treated with the compound, with 60-80% protection against life-threatening effects, compared to the outcomes of DENV-infected mice treated with saline...
March 28, 2024: Journal of Virology
https://read.qxmd.com/read/38546207/development-of-high-performance-iron-based-phosphate-cathodes-toward-practical-na-ion-batteries
#40
JOURNAL ARTICLE
Chunliu Xu, Lin Zhou, Teng Gao, Zhao Chen, Xueyan Hou, Jiao Zhang, Ying Bai, Liangrong Yang, Huizhou Liu, Chao Yang, Junmei Zhao, Yong-Sheng Hu
Iron-based phosphate cathode of Na4 Fe3 (PO4 )2 (P2 O7 ) has been regarded as a low-cost and structurally stable cathode material for Na-ion batteries (NIBs). However, their practical application is greatly hindered by the insufficient electrochemical performance and limited energy density. Here, we report a new iron-based phosphate cathode of Na4.5 Fe3.5 (PO4 )2.5 (P2 O7 ) with the intergrown heterostructure of the maricite-type NaFePO4 and orthorhombic Na4 Fe3 (PO4 )2 (P2 O7 ) phases at a mole ratio of 0...
March 28, 2024: Journal of the American Chemical Society
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